--- _id: '3551' abstract: - lang: eng text: Common geometric models for proteins and other molecules are the space filling diagram, the solvent accessible surface, and the molecular surface. We describe software that computes metric properties of these models, including volume and surface area. It also measures voids or empty space enclosed by the protein, and it keeps track of surface area contributions of individual atoms. The software is based on 3-dimensional alpha complexes and on inclusion-exclusion formulas with terms derived from the simplices in this complex. article_processing_charge: No author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Michael full_name: Facello, Michael last_name: Facello - first_name: Ping full_name: Fu, Ping last_name: Fu - first_name: Jie full_name: Liang, Jie last_name: Liang citation: ama: 'Edelsbrunner H, Facello M, Fu P, Liang J. Measuring proteins and voids in proteins. In: Proceedings of the 28th Annual Hawaii International Conference on System Sciences. IEEE; 1995:256-264. doi:10.1109/HICSS.1995.375331' apa: 'Edelsbrunner, H., Facello, M., Fu, P., & Liang, J. (1995). Measuring proteins and voids in proteins. In Proceedings of the 28th Annual Hawaii International Conference on System Sciences (pp. 256–264). Wailea, HI, United States of America: IEEE. https://doi.org/10.1109/HICSS.1995.375331' chicago: Edelsbrunner, Herbert, Michael Facello, Ping Fu, and Jie Liang. “Measuring Proteins and Voids in Proteins.” In Proceedings of the 28th Annual Hawaii International Conference on System Sciences, 256–64. IEEE, 1995. https://doi.org/10.1109/HICSS.1995.375331. ieee: H. Edelsbrunner, M. Facello, P. Fu, and J. Liang, “Measuring proteins and voids in proteins,” in Proceedings of the 28th Annual Hawaii International Conference on System Sciences, Wailea, HI, United States of America, 1995, pp. 256–264. ista: 'Edelsbrunner H, Facello M, Fu P, Liang J. 1995. Measuring proteins and voids in proteins. Proceedings of the 28th Annual Hawaii International Conference on System Sciences. HICSS: Hawaii International Conference on System Sciences, 256–264.' mla: Edelsbrunner, Herbert, et al. “Measuring Proteins and Voids in Proteins.” Proceedings of the 28th Annual Hawaii International Conference on System Sciences, IEEE, 1995, pp. 256–64, doi:10.1109/HICSS.1995.375331. short: H. Edelsbrunner, M. Facello, P. Fu, J. Liang, in:, Proceedings of the 28th Annual Hawaii International Conference on System Sciences, IEEE, 1995, pp. 256–264. conference: end_date: 1995-01-06 location: Wailea, HI, United States of America name: 'HICSS: Hawaii International Conference on System Sciences' start_date: 1995-01-03 date_created: 2018-12-11T12:03:55Z date_published: 1995-01-04T00:00:00Z date_updated: 2022-06-27T13:54:41Z day: '04' doi: 10.1109/HICSS.1995.375331 extern: '1' language: - iso: eng main_file_link: - url: https://ieeexplore.ieee.org/document/375331 month: '01' oa_version: None page: 256 - 264 publication: Proceedings of the 28th Annual Hawaii International Conference on System Sciences publication_identifier: isbn: - 0-8186-6930-6 publication_status: published publisher: IEEE publist_id: '2834' quality_controlled: '1' scopus_import: '1' status: public title: Measuring proteins and voids in proteins type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '1995' ... --- _id: '3552' abstract: - lang: eng text: "The concept of an α-shape of a finite set of points in R^d, with weights, is defined and illustrated. An α-shape is a polytope which is not necessarily convex nor connected and can be derived from the (weighted) Delaunay triangulation of the point set, with a parameter controlling the desired level of detail. The set of all α values leads to a descrete family of shapes capturing the intuitive notion of ``crude'' versus ``fine'' shapes of a point set. Software that computes such shapes in R^2 and R^3 is available via anonymous ftp from:\r\n\r\nftp://ftp.ncsa.uiuc.edu/Visualization/Alpha-shape/ \ " article_processing_charge: No author: - first_name: Nataraj full_name: Akkiraju, Nataraj last_name: Akkiraju - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Michael full_name: Facello, Michael last_name: Facello - first_name: Ping full_name: Fu, Ping last_name: Fu - first_name: Ernst full_name: Mücke, Ernst last_name: Mücke - first_name: Carlos full_name: Varela, Carlos last_name: Varela citation: ama: 'Akkiraju N, Edelsbrunner H, Facello M, Fu P, Mücke E, Varela C. Alpha shapes: definition and software. In: Elsevier; 1995:63-66.' apa: 'Akkiraju, N., Edelsbrunner, H., Facello, M., Fu, P., Mücke, E., & Varela, C. (1995). Alpha shapes: definition and software (pp. 63–66). Presented at the GCG: International Computational Geometry Software Workshop, Elsevier.' chicago: 'Akkiraju, Nataraj, Herbert Edelsbrunner, Michael Facello, Ping Fu, Ernst Mücke, and Carlos Varela. “Alpha Shapes: Definition and Software,” 63–66. Elsevier, 1995.' ieee: 'N. Akkiraju, H. Edelsbrunner, M. Facello, P. Fu, E. Mücke, and C. Varela, “Alpha shapes: definition and software,” presented at the GCG: International Computational Geometry Software Workshop, 1995, pp. 63–66.' ista: 'Akkiraju N, Edelsbrunner H, Facello M, Fu P, Mücke E, Varela C. 1995. Alpha shapes: definition and software. GCG: International Computational Geometry Software Workshop, 63–66.' mla: 'Akkiraju, Nataraj, et al. Alpha Shapes: Definition and Software. Elsevier, 1995, pp. 63–66.' short: N. Akkiraju, H. Edelsbrunner, M. Facello, P. Fu, E. Mücke, C. Varela, in:, Elsevier, 1995, pp. 63–66. conference: name: 'GCG: International Computational Geometry Software Workshop' date_created: 2018-12-11T12:03:55Z date_published: 1995-09-11T00:00:00Z date_updated: 2022-06-27T13:20:29Z day: '11' extern: '1' language: - iso: eng main_file_link: - url: http://www.geom.uiuc.edu/software/cglist/GeomDir/shapes95def/ month: '09' oa_version: None page: 63 - 66 publication_status: published publisher: Elsevier publist_id: '2833' quality_controlled: '1' status: public title: 'Alpha shapes: definition and software' type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '1995' ... --- _id: '3636' abstract: - lang: eng text: 'Observations on the means, variances, and covariances of quantitative traits across hybrid zones can give information similar to that from Mendelian markers. In addition, they can identify particular traits through which the cline is maintained. We describe a survey of six traits across the hybrid zone between Bombina bombina and Bombina variegata (Amphibia: Discoglossidae) near Pescenica in Croatia. We obtained laboratory measuments of the belly pattern, skin thickness, mating call, skeletal form, egg size, and the developmental time of tadpoles. Although offspring from hybrid populations showed no evidence of reduced viability, a third of the F1 families failed completely, irrespective of the direction of the cross. All traits differed significantly between the taxa. Clines in belly pattern, skin thickness, mating call, and skeletal form were closely concordant with clines in four diagnostic enzyme loci. However, the cline in developmental time was displaced towards bombina, and the cline in egg size was displaced towards variegata. This discordance could be because the traits are not inherited additively or because they are subject to different selection pressures. We favor the latter explanation in the case of developmental time. We show that moderate selection acting directly on a trait suffices to shift its position; rather stronger selection is needed to change its width appreciably. Within hybrid populations, there are significant associations among quantitative traits, and between traits and enzymes. Phenotypic variances also increase in hybrid populations. These observations can be explained by linkage disequilibria among the underlying loci. However, the average magnitude of the covariance between traits is about half that expected from the linkage disequilibria between enzyme loci. The discrepancy is not readily explained by nonadditive gene action. This puzzle is now unresolved and calls for further investigation.' acknowledgement: 'The project would not have been possible without F. Perovic''s extensive knowledge of the natural history of the Pegdenica area, and his assistance in the field. Particular thanks are due to the Perovie family for their generous hospitality. The Croatian Museum of Natural History and the Croatian Ministry of the Environment were helpful in granting all the necessary permits. J. Szymura assisted with allozyme tech-niques and in sharing unpublished data from his original survey of the area. M. Davidson and K. Grant prepared the histological specimens, and G. Patterson volunteered time and expertise in X-raying our toads. All members of L. Partridge''s lab generously provided us with toad food on a daily basis, in the form of uncountably many spare Drosophila. G. Malarky and M. Oh stoically coped with much tedious toad care. We thank W. G. Hill, L. Kruuk, D. Rand, J. Szymura, and an anonymous reviewer for helpful comments on the manuscript. This research was supported by a grant from the Natural Environment Research Council (GR3/8002) to N.B. ' article_processing_charge: No article_type: original author: - first_name: Beate full_name: Nürnberger, Beate last_name: Nürnberger - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Catriona full_name: Maccallum, Catriona last_name: Maccallum - first_name: Jason full_name: Gilchrist, Jason last_name: Gilchrist - first_name: Michael full_name: Appleby, Michael last_name: Appleby citation: ama: Nürnberger B, Barton NH, Maccallum C, Gilchrist J, Appleby M. Natural selection on quantitative traits in the Bombina hybrid zone. Evolution. 1995;49(6):1224-1238. doi:10.1111/j.1558-5646.1995.tb04449.x apa: Nürnberger, B., Barton, N. H., Maccallum, C., Gilchrist, J., & Appleby, M. (1995). Natural selection on quantitative traits in the Bombina hybrid zone. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1995.tb04449.x chicago: Nürnberger, Beate, Nicholas H Barton, Catriona Maccallum, Jason Gilchrist, and Michael Appleby. “Natural Selection on Quantitative Traits in the Bombina Hybrid Zone.” Evolution. Wiley-Blackwell, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb04449.x. ieee: B. Nürnberger, N. H. Barton, C. Maccallum, J. Gilchrist, and M. Appleby, “Natural selection on quantitative traits in the Bombina hybrid zone,” Evolution, vol. 49, no. 6. Wiley-Blackwell, pp. 1224–1238, 1995. ista: Nürnberger B, Barton NH, Maccallum C, Gilchrist J, Appleby M. 1995. Natural selection on quantitative traits in the Bombina hybrid zone. Evolution. 49(6), 1224–1238. mla: Nürnberger, Beate, et al. “Natural Selection on Quantitative Traits in the Bombina Hybrid Zone.” Evolution, vol. 49, no. 6, Wiley-Blackwell, 1995, pp. 1224–38, doi:10.1111/j.1558-5646.1995.tb04449.x. short: B. Nürnberger, N.H. Barton, C. Maccallum, J. Gilchrist, M. Appleby, Evolution 49 (1995) 1224–1238. date_created: 2018-12-11T12:04:22Z date_published: 1995-12-01T00:00:00Z date_updated: 2022-06-27T12:58:02Z day: '01' doi: 10.1111/j.1558-5646.1995.tb04449.x extern: '1' intvolume: ' 49' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1995.tb04449.x month: '12' oa: 1 oa_version: Published Version page: 1224 - 1238 publication: Evolution publication_identifier: issn: - 0014-3820 publication_status: published publisher: Wiley-Blackwell publist_id: '2747' quality_controlled: '1' scopus_import: '1' status: public title: Natural selection on quantitative traits in the Bombina hybrid zone type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '1995' ... --- _id: '3637' abstract: - lang: eng text: 'Hybridizing taxa remain distinct for two main reasons. Natural selection acts against hybrids either because of their incompatible genome, or because of differential adaptation of the pure types across an environmental gradient. Here, we provide experimental evidence that the location of the Bombina (Anura: Discoglossidae) hybrid zone in Croatia is, at least in part, determined by differential adaptation. B. bombina typically breeds in permanent water in the lowland, whereas B. variegata reproduces in puddles at higher elevations. In a reciprocal translocation, pure bombina and variegata tadpoles were introduced in equal proportions into lowland pond enclosures and upland puddles. After three weeks, variegata exceeded bombina in survival and growth in both habitats. The effect was most pronounced in puddles, where the few surviving bombina tadpoles had hardly grown at all. In comparison to variegata, the smaller hatchlings of bombina grew relatively faster in ponds, but remained smaller in absolute terms. Nevertheless, B. bombina appears better adapted to ponds than to puddles. The mechanisms by which variegata is excluded from ponds remain to be demonstrated. These data show that habitat dependent selection prevents the invasion of bombina tadpole traits into the variegata gene pool. Given the strong linkage disequilibria in hybrid populations, differential selection on tadpoles may be sufficient to maintain the integrity of the two gene pools.' acknowledgement: We thank Franjo Perovioc for invaluable help in the field and the Perovioc family for generous hospitality. Logistical and practical support was provided by the Croatian Museum of Natural History in particular Bojan Lazar and Eduarrd Kletecki. The people of Velesevec kindly tolerated our enclosure bags in their village pond. Stejpan Ticeric generously provided a base for our work in Perkovec. Professor S. Jelaska of the U niversity of Zagreb allowed us unlim ited access to her laboratory, where all tadpole m easurem ents were taken. Loeske K ruuk carried out the electrophoretic analysis which established the taxonomic significance of tadpole belly colour. We thank Ian Wilson for statistical advice and Tim Halliday, Peter Jones, Loeske Kruuk, Jaroslav Pialek and two anonymous referees for helpful comments on the manuscript. This research was supported by a grant from the NERC (No. GR3/8002) to N.H.B. article_processing_charge: No article_type: original author: - first_name: Catriona full_name: Maccallum, Catriona last_name: Maccallum - first_name: Beate full_name: Nürnberger, Beate last_name: Nürnberger - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Maccallum C, Nürnberger B, Barton NH. Experimental evidence for habitat dependent selection in a Bombina hybrid zone. Proceedings of the Royal Society of London Series B Biological Sciences. 1995;260(1359):257-264. doi:10.1098/rspb.1995.0089 apa: Maccallum, C., Nürnberger, B., & Barton, N. H. (1995). Experimental evidence for habitat dependent selection in a Bombina hybrid zone. Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society of London. https://doi.org/10.1098/rspb.1995.0089 chicago: Maccallum, Catriona, Beate Nürnberger, and Nicholas H Barton. “Experimental Evidence for Habitat Dependent Selection in a Bombina Hybrid Zone.” Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society of London, 1995. https://doi.org/10.1098/rspb.1995.0089. ieee: C. Maccallum, B. Nürnberger, and N. H. Barton, “Experimental evidence for habitat dependent selection in a Bombina hybrid zone,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 260, no. 1359. Royal Society of London, pp. 257–264, 1995. ista: Maccallum C, Nürnberger B, Barton NH. 1995. Experimental evidence for habitat dependent selection in a Bombina hybrid zone. Proceedings of the Royal Society of London Series B Biological Sciences. 260(1359), 257–264. mla: Maccallum, Catriona, et al. “Experimental Evidence for Habitat Dependent Selection in a Bombina Hybrid Zone.” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 260, no. 1359, Royal Society of London, 1995, pp. 257–64, doi:10.1098/rspb.1995.0089. short: C. Maccallum, B. Nürnberger, N.H. Barton, Proceedings of the Royal Society of London Series B Biological Sciences 260 (1995) 257–264. date_created: 2018-12-11T12:04:22Z date_published: 1995-06-22T00:00:00Z date_updated: 2022-06-27T10:14:02Z day: '22' doi: 10.1098/rspb.1995.0089 extern: '1' intvolume: ' 260' issue: '1359' language: - iso: eng main_file_link: - url: https://royalsocietypublishing.org/doi/10.1098/rspb.1995.0089 month: '06' oa_version: None page: 257 - 264 publication: Proceedings of the Royal Society of London Series B Biological Sciences publication_identifier: issn: - 0962-8452 publication_status: published publisher: Royal Society of London publist_id: '2746' quality_controlled: '1' scopus_import: '1' status: public title: Experimental evidence for habitat dependent selection in a Bombina hybrid zone type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 260 year: '1995' ... --- _id: '3639' abstract: - lang: eng text: 'A general representation of multilocus selection is extended to allow recombination to depend on genotype. The equations simplify if modifier alleles have small effects on recombination. The evolution of such modifiers only depends on how they alter recombination between the selected loci, and does not involve dominance in modifier effects. The net selection on modifiers can be found explicitly if epistasis is weak relative to recombination. This analysis shows that recombination can be favoured in two ways: because it impedes the response to epistasis which fluctuates in sign, or because it facilitates the response to directional selection. The first mechanism is implausible, because epistasis must change sign over periods of a few generations: faster or slower fluctuations favour reduced recombination. The second mechanism requires weak negative epistasis between favourable alleles, which may either be increasing, or held in check by mutation. The selection (si) on recombination modifiers depends on the reduction in additive variance of log (fitness) due to linkage disequilibria (υ1 < 0), and on non-additive variance in log (fitness) (V′2, V′3,.. epistasis between 2, 3.. loci). For unlinked loci and pairwise epistasis, si = − (υ1 + 4V2/3)δr, where δr is the average increase in recombination caused by the modifier. The approximations are checked against exact calculations for three loci, and against Charlesworth''s analyses of mutation/selection balance (1990), and directional selection (1993). The analysis demonstrates a general relation between selection on recombination and observable components of fitness variation, which is open to experimental test.' article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Barton NH. A general model for the evolution of recombination. Genetical Research. 1995;65(2):123-144. doi:10.1017/S0016672300033140 apa: Barton, N. H. (1995). A general model for the evolution of recombination. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672300033140 chicago: Barton, Nicholas H. “A General Model for the Evolution of Recombination.” Genetical Research. Cambridge University Press, 1995. https://doi.org/10.1017/S0016672300033140. ieee: N. H. Barton, “A general model for the evolution of recombination,” Genetical Research, vol. 65, no. 2. Cambridge University Press, pp. 123–144, 1995. ista: Barton NH. 1995. A general model for the evolution of recombination. Genetical Research. 65(2), 123–144. mla: Barton, Nicholas H. “A General Model for the Evolution of Recombination.” Genetical Research, vol. 65, no. 2, Cambridge University Press, 1995, pp. 123–44, doi:10.1017/S0016672300033140. short: N.H. Barton, Genetical Research 65 (1995) 123–144. date_created: 2018-12-11T12:04:23Z date_published: 1995-04-01T00:00:00Z date_updated: 2022-06-24T11:54:10Z day: '01' doi: 10.1017/S0016672300033140 extern: '1' external_id: pmid: - '7605514' intvolume: ' 65' issue: '2' language: - iso: eng main_file_link: - url: https://www.cambridge.org/core/journals/genetics-research/article/general-model-for-the-evolution-of-recombination/8CBDDF2DC779CF4B6AE9B461B80BB4AE month: '04' oa_version: None page: 123 - 144 pmid: 1 publication: Genetical Research publication_identifier: issn: - 0016-6723 publication_status: published publisher: Cambridge University Press publist_id: '2744' quality_controlled: '1' scopus_import: '1' status: public title: A general model for the evolution of recombination type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 65 year: '1995' ... --- _id: '3638' abstract: - lang: eng text: 'Any sample of genes traces back to a single common ancestor. Each gene also has other properties: its sequence, its geographic location and the phenotype and fitness of the organism that carries it. With sexual reproduction, different genes have different genealogies, which gives us much more information, but also greatly complicates population genetic analysis. We review the close relation between the distribution of genealogies and the classic theory of identity by descent in spatially structured populations, and develop a simple diffusion approximation to the distribution of coalescence times in a homogeneous two-dimensional habitat. This shows that when neighbourhood size is large (as in most populations) only a small fraction of pairs of genes are closely related, and only this fraction gives information about current rates of gene flow. The increase of spatial dispersion with lineage age is thus a poor estimator of gene flow. The bulk of the genealogy depends on the long-term history of the population; we discuss ways of inferring this history from the concordance between genealogies across loci.' acknowledgement: This work was supported by BBSRC grant GR/H/09928 and by a Scottish Office studentship. We thank A. W. F. Edwards and S. Otto for their helpful comments. article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: I full_name: Wilson, I last_name: Wilson citation: ama: Barton NH, Wilson I. Genealogies and geography. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences. 1995;349(1327):49-59. doi:10.1098/rstb.1995.0090 apa: Barton, N. H., & Wilson, I. (1995). Genealogies and geography. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Royal Society, The. https://doi.org/10.1098/rstb.1995.0090 chicago: Barton, Nicholas H, and I Wilson. “Genealogies and Geography.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Royal Society, The, 1995. https://doi.org/10.1098/rstb.1995.0090. ieee: N. H. Barton and I. Wilson, “Genealogies and geography,” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 349, no. 1327. Royal Society, The, pp. 49–59, 1995. ista: Barton NH, Wilson I. 1995. Genealogies and geography. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 349(1327), 49–59. mla: Barton, Nicholas H., and I. Wilson. “Genealogies and Geography.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 349, no. 1327, Royal Society, The, 1995, pp. 49–59, doi:10.1098/rstb.1995.0090. short: N.H. Barton, I. Wilson, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 349 (1995) 49–59. date_created: 2018-12-11T12:04:22Z date_published: 1995-07-29T00:00:00Z date_updated: 2022-06-27T08:55:07Z day: '29' doi: 10.1098/rstb.1995.0090 extern: '1' external_id: pmid: - '8748019' intvolume: ' 349' issue: '1327' language: - iso: eng main_file_link: - url: https://royalsocietypublishing.org/doi/10.1098/rstb.1995.0090 month: '07' oa_version: None page: 49 - 59 pmid: 1 publication: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences publication_identifier: issn: - 0962-8436 publication_status: published publisher: Royal Society, The publist_id: '2745' quality_controlled: '1' status: public title: Genealogies and geography type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 349 year: '1995' ... --- _id: '4035' abstract: - lang: eng text: 'Let S be a set of n points in ℝd . A set W is a weak ε-net for (convex ranges of)S if, for any T⊆S containing εn points, the convex hull of T intersects W. We show the existence of weak ε-nets of size {Mathematical expression}, where β2=0, β3=1, and βd ≈0.149·2d-1(d-1)!, improving a previous bound of Alon et al. Such a net can be computed effectively. We also consider two special cases: when S is a planar point set in convex position, we prove the existence of a net of size O((1/ε) log1.6(1/ε)). In the case where S consists of the vertices of a regular polygon, we use an argument from hyperbolic geometry to exhibit an optimal net of size O(1/ε), which improves a previous bound of Capoyleas.' acknowledgement: The authors wish to express their gratitude for the support and hospitality of the DEC Palo Alto Systems Research Center. article_processing_charge: No article_type: original author: - first_name: Bernard full_name: Chazelle, Bernard last_name: Chazelle - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Michelangelo full_name: Grigni, Michelangelo last_name: Grigni - first_name: Leonidas full_name: Guibas, Leonidas last_name: Guibas - first_name: Micha full_name: Sharir, Micha last_name: Sharir - first_name: Emo full_name: Welzl, Emo last_name: Welzl citation: ama: Chazelle B, Edelsbrunner H, Grigni M, Guibas L, Sharir M, Welzl E. Improved bounds on weak ε-nets for convex sets. Discrete & Computational Geometry. 1995;13(1):1-15. doi:10.1007/BF02574025 apa: Chazelle, B., Edelsbrunner, H., Grigni, M., Guibas, L., Sharir, M., & Welzl, E. (1995). Improved bounds on weak ε-nets for convex sets. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/BF02574025 chicago: Chazelle, Bernard, Herbert Edelsbrunner, Michelangelo Grigni, Leonidas Guibas, Micha Sharir, and Emo Welzl. “Improved Bounds on Weak ε-Nets for Convex Sets.” Discrete & Computational Geometry. Springer, 1995. https://doi.org/10.1007/BF02574025. ieee: B. Chazelle, H. Edelsbrunner, M. Grigni, L. Guibas, M. Sharir, and E. Welzl, “Improved bounds on weak ε-nets for convex sets,” Discrete & Computational Geometry, vol. 13, no. 1. Springer, pp. 1–15, 1995. ista: Chazelle B, Edelsbrunner H, Grigni M, Guibas L, Sharir M, Welzl E. 1995. Improved bounds on weak ε-nets for convex sets. Discrete & Computational Geometry. 13(1), 1–15. mla: Chazelle, Bernard, et al. “Improved Bounds on Weak ε-Nets for Convex Sets.” Discrete & Computational Geometry, vol. 13, no. 1, Springer, 1995, pp. 1–15, doi:10.1007/BF02574025. short: B. Chazelle, H. Edelsbrunner, M. Grigni, L. Guibas, M. Sharir, E. Welzl, Discrete & Computational Geometry 13 (1995) 1–15. date_created: 2018-12-11T12:06:33Z date_published: 1995-12-01T00:00:00Z date_updated: 2022-06-13T12:37:06Z day: '01' doi: 10.1007/BF02574025 extern: '1' intvolume: ' 13' issue: '1' language: - iso: eng main_file_link: - url: https://link.springer.com/article/10.1007/BF02574025 month: '12' oa_version: None page: 1 - 15 publication: Discrete & Computational Geometry publication_identifier: issn: - 0179-5376 publication_status: published publisher: Springer publist_id: '2094' quality_controlled: '1' status: public title: Improved bounds on weak ε-nets for convex sets type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 13 year: '1995' ... --- _id: '4034' abstract: - lang: eng text: Any arbitrary polyhedron P contained as a subset within Rd can be written as algebraic sum of simple terms, each an integer multiple of the intersection of d or fewer half-spaces defined by facets of P. P can be non-convex and can have holes of any kind. Among the consequences of this result are a short boolean formula for P, a fast parallel algorithm for point classification, and a new proof of the Gram-Sommerville angle relation. acknowledgement: The author thanks Bei-Fang Chen, Siu-Wing Cheng, David Dobkin, Nikolai Dolbilin, Ping Fu, Sergei Ryshkov, and Vadim Shapiro for discussions on the topic of this paper. article_processing_charge: No author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: 'Edelsbrunner H. Algebraic decomposition of non-convex polyhedra. In: Proceedings of IEEE 36th Annual Foundations of Computer Science. IEEE; 1995:248-257.' apa: 'Edelsbrunner, H. (1995). Algebraic decomposition of non-convex polyhedra. In Proceedings of IEEE 36th Annual Foundations of Computer Science (pp. 248–257). Milwaukee, WI, United States of America: IEEE.' chicago: Edelsbrunner, Herbert. “Algebraic Decomposition of Non-Convex Polyhedra.” In Proceedings of IEEE 36th Annual Foundations of Computer Science, 248–57. IEEE, 1995. ieee: H. Edelsbrunner, “Algebraic decomposition of non-convex polyhedra,” in Proceedings of IEEE 36th Annual Foundations of Computer Science, Milwaukee, WI, United States of America, 1995, pp. 248–257. ista: 'Edelsbrunner H. 1995. Algebraic decomposition of non-convex polyhedra. Proceedings of IEEE 36th Annual Foundations of Computer Science. FOCS: Foundations of Computer Science, 248–257.' mla: Edelsbrunner, Herbert. “Algebraic Decomposition of Non-Convex Polyhedra.” Proceedings of IEEE 36th Annual Foundations of Computer Science, IEEE, 1995, pp. 248–57. short: H. Edelsbrunner, in:, Proceedings of IEEE 36th Annual Foundations of Computer Science, IEEE, 1995, pp. 248–257. conference: end_date: 1995-10-25 location: Milwaukee, WI, United States of America name: 'FOCS: Foundations of Computer Science' start_date: 1995-10-23 date_created: 2018-12-11T12:06:33Z date_published: 1995-10-01T00:00:00Z date_updated: 2022-06-13T12:27:11Z day: '01' extern: '1' language: - iso: eng main_file_link: - url: https://ieeexplore.ieee.org/abstract/document/492480 month: '10' oa_version: None page: 248 - 257 publication: Proceedings of IEEE 36th Annual Foundations of Computer Science publication_identifier: issn: - 0272-5428 publication_status: published publisher: IEEE publist_id: '2093' quality_controlled: '1' status: public title: Algebraic decomposition of non-convex polyhedra type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '1995' ... --- _id: '4153' article_processing_charge: No article_type: original author: - first_name: D. full_name: Ransom, D. last_name: Ransom - first_name: Alison full_name: Brownlie, Alison last_name: Brownlie - first_name: Pascal full_name: Haffter, Pascal last_name: Haffter - first_name: Jörg full_name: Odenthal, Jörg last_name: Odenthal - first_name: Robert full_name: Kelsh, Robert last_name: Kelsh - first_name: Michael full_name: Brand, Michael last_name: Brand - first_name: Makoto full_name: Furutani Seiki, Makoto last_name: Furutani Seiki - first_name: Michael full_name: Granato, Michael last_name: Granato - first_name: Matthias full_name: Hammerschmidt, Matthias last_name: Hammerschmidt - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Yunjin full_name: Jiang, Yunjin last_name: Jiang - first_name: David full_name: Kane, David last_name: Kane - first_name: Mary full_name: Mullins, Mary last_name: Mullins - first_name: Fredericus full_name: Van Eden, Fredericus last_name: Van Eden - first_name: Rachel full_name: Warga, Rachel last_name: Warga - first_name: Christiane full_name: Nüsslein Volhard, Christiane last_name: Nüsslein Volhard - first_name: L. full_name: Zon, L. last_name: Zon citation: ama: Ransom D, Brownlie A, Haffter P, et al. Hematopoietic mutants identified in a saturation screen of the zebrafish genome. Blood. 1995;86(10):1912-1912. apa: Ransom, D., Brownlie, A., Haffter, P., Odenthal, J., Kelsh, R., Brand, M., … Zon, L. (1995). Hematopoietic mutants identified in a saturation screen of the zebrafish genome. Blood. American Society of Hematology. chicago: Ransom, D., Alison Brownlie, Pascal Haffter, Jörg Odenthal, Robert Kelsh, Michael Brand, Makoto Furutani Seiki, et al. “Hematopoietic Mutants Identified in a Saturation Screen of the Zebrafish Genome.” Blood. American Society of Hematology, 1995. ieee: D. Ransom et al., “Hematopoietic mutants identified in a saturation screen of the zebrafish genome,” Blood, vol. 86, no. 10. American Society of Hematology, pp. 1912–1912, 1995. ista: Ransom D, Brownlie A, Haffter P, Odenthal J, Kelsh R, Brand M, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Mullins M, Van Eden F, Warga R, Nüsslein Volhard C, Zon L. 1995. Hematopoietic mutants identified in a saturation screen of the zebrafish genome. Blood. 86(10), 1912–1912. mla: Ransom, D., et al. “Hematopoietic Mutants Identified in a Saturation Screen of the Zebrafish Genome.” Blood, vol. 86, no. 10, American Society of Hematology, 1995, pp. 1912–1912. short: D. Ransom, A. Brownlie, P. Haffter, J. Odenthal, R. Kelsh, M. Brand, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, M. Mullins, F. Van Eden, R. Warga, C. Nüsslein Volhard, L. Zon, Blood 86 (1995) 1912–1912. date_created: 2018-12-11T12:07:16Z date_published: 1995-01-01T00:00:00Z date_updated: 2022-06-13T12:02:52Z day: '01' extern: '1' intvolume: ' 86' issue: '10' language: - iso: eng month: '01' oa_version: None page: 1912 - 1912 publication: Blood publication_identifier: issn: - 0006-4971 publication_status: published publisher: American Society of Hematology publist_id: '1965' quality_controlled: '1' status: public title: Hematopoietic mutants identified in a saturation screen of the zebrafish genome type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 86 year: '1995' ... --- _id: '3479' abstract: - lang: eng text: 1. Glutamate receptor (GluR) channels were studied in basket cells in the dentate gyrus of rat hippocampal slices. Basket cells were identified by their location, dendritic morphology and high frequency of action potentials generated during sustained current injection. 2. Dual-component currents were activated by fast application of glutamate to outside-out membrane patches isolated from basket cell somata (10 μM glycine, no external Mg2+). The fast component was selectively blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), the slow component by D-2-amino-5-phosphonopentanoic acid (D-AP5). This suggests that the two components were mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR)/kainate receptor and N-methyl-D-aspartate receptor (NMDAR) channels, respectively. The mean ratio of the peak current of the NMDAR component to that of the AMPAR/kainate receptor component was 0.22 (1 ms pulses of 10 mM glutamate). 3. The AMPAR/kainate receptor component, which was studied in isolation in the presence of D-AP5, was identified as AMPAR mediated on the basis of the preferential activation by AMPA as compared with kainate, the weak desensitization of kainate-activated currents, the cross-desensitization between AMPA and kainate, and the reduction of desensitization by cyclothiazide. 4. Deactivation of basket cell AMPARs following 1 ms pulses of glutamate occurred with a time constant (τ) of 1.2 ± 0.1 ms (mean ± S.E.M.). During 100 ms glutamate pulses, AMPARs desensitized with a τ of 3.7 ± 0.2 ms. 5. The peak current-voltage (I-V) relation of AMPAR-mediated currents in Na+-rich extracellular solution showed a reversal potential of -4.0 ± 2.6 mV and was characterized by a doubly rectifying shape. The conductance of single AMPAR channels was estimated as 22.6 ± 1.6 pS using non-stationary fluctuation analysis. AMPARs expressed in hippocampal basket cells mere highly Ca2+ permeable (P(Ca)/P(K) = 1.79). 6. NMDARs in hippocampal basket cells were studied in isolation in the presence of CNQX. Deactivation of NMDARs activated by glutamate pulses occurred bi-exponentially with mean τ values of 266 ± 23 ms (76%) and 2620 ± 383 ms (24%). 7. The peak I-V relation of the NMDAR-mediated component in Na+-rich extracellular solution showed a reversal potential of 1.5 ± 0.6 mV and a region of negative slope at negative membrane potentials in the presence of external Mg2+, due to voltage-dependent block by these ions. The conductance of single NMDAR channels in the main open state was 50.2 ± 1.8 pS. NMDARs in hippocampal basket cells were highly permeable to Ca2+ (P(Ca)/P(K) = 6.68). 8. AMPARs in hippocampal basket cells are characterized by about threefold faster kinetics and twentyfold higher Ca2+ permeability than AMPARs in hippocampal granule or pyramidal cells. Simulations show that the Ca2+ influx through basket cell AMPARs is comparable to that through NMDARs at negative membrane potentials with physiological concentrations of Ca2+ and Mg2+. This suggests a dual pathway of synaptically mediated Ca2+ entry into interneurones. acknowledgement: We thank Drs M.Häusser and H.Markram for critically reading the manuscript and M.Kaiser for technical assistance. Supported by the Deutsche Forschungsgemeinschaft (SFB-317/B14 grant to P.J. and a Graduiertenkollegstipendium to J.R.P.G.) article_processing_charge: No article_type: original author: - first_name: Duk full_name: Koh, Duk last_name: Koh - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Bert full_name: Sakmann, Bert last_name: Sakmann citation: ama: Koh D, Geiger J, Jonas PM, Sakmann B. Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus. Journal of Physiology. 1995;485(Pt 2):383-402. doi:10.1113/jphysiol.1995.sp020737 apa: Koh, D., Geiger, J., Jonas, P. M., & Sakmann, B. (1995). Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020737 chicago: Koh, Duk, Jörg Geiger, Peter M Jonas, and Bert Sakmann. “Ca(2+)-Permeable AMPA and NMDA Receptor Channels in Basket Cells of Rat Hippocampal Dentate Gyrus.” Journal of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020737. ieee: D. Koh, J. Geiger, P. M. Jonas, and B. Sakmann, “Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus,” Journal of Physiology, vol. 485, no. Pt 2. Wiley-Blackwell, pp. 383–402, 1995. ista: Koh D, Geiger J, Jonas PM, Sakmann B. 1995. Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus. Journal of Physiology. 485(Pt 2), 383–402. mla: Koh, Duk, et al. “Ca(2+)-Permeable AMPA and NMDA Receptor Channels in Basket Cells of Rat Hippocampal Dentate Gyrus.” Journal of Physiology, vol. 485, no. Pt 2, Wiley-Blackwell, 1995, pp. 383–402, doi:10.1113/jphysiol.1995.sp020737. short: D. Koh, J. Geiger, P.M. Jonas, B. Sakmann, Journal of Physiology 485 (1995) 383–402. date_created: 2018-12-11T12:03:33Z date_published: 1995-06-01T00:00:00Z date_updated: 2022-06-28T07:54:44Z day: '01' doi: 10.1113/jphysiol.1995.sp020737 extern: '1' external_id: pmid: - '7545230' intvolume: ' 485' issue: Pt 2 language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1158000/pdf/jphysiol00319-0104.pdf month: '06' oa: 1 oa_version: Published Version page: 383 - 402 pmid: 1 publication: Journal of Physiology publication_identifier: issn: - 0022-3751 publication_status: published publisher: Wiley-Blackwell publist_id: '2908' quality_controlled: '1' scopus_import: '1' status: public title: Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 485 year: '1995' ... --- _id: '3481' abstract: - lang: eng text: 1. The influence of intracellular factors on current rectification of different subtypes of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) was studied in rat brain slices by combining fast application of glutamate with patch pipette perfusion. 2. The peak current-voltage (I-V) relation of the AMPARs expressed in Bergmann glial cells of cerebellum and dentate gyrus (DG) basket cells of hippocampus was weakly rectifying in outside-out patches and nystatin-perforated vesicles, but showed a doubly rectifying shape with a region of reduced slope between 0 and +40 mV in nucleated patches. The I-V relation of AMPARs expressed in hippocampal CA3 pyramidal neurones was linear in all recording configurations. 3. Intracellular application of 2.5 μM spermine, a naturally occurring polyamine, blocked outward currents in outside-oat patches from Bergmann glial cells and DG basket cells in a voltage-dependent manner, generating I-V relations with a doubly rectifying shape which were similar to those recorded in nucleated patches. AMPARs in CA3 pyramidal cell patches were unaffected by 25 μM spermine. 4. The half-maximal blocking concentration of spermine at +40 mV was 0.3 μM in Bergmann glial cell patches and 1.5 μM in DG basket cell patches, whereas it was much higher (≥ 100 μM) for CA3 pyramidal. cell patches. Spermidine also affected current rectification, but with lower affinity. The block of outward current by polyamines following voltage jumps developed within < 0.5 ms. 5. We conclude that current rectification, rather than being an intrinsic property of the Ca2+ permeable AMPAR channel, is generated by polyamine block. acknowledgement: We thank Dr B.Sakmann, Dr V.Witzemann, J.Geiger, and A.Roth for helpful discussions and Dr D.Feldmeyer and Dr A.Villarroel for reading the manuscript. We also thank M.Kaiser for technical and H.Spiegel for secretarial assistance. Supported by DFG grant SFB-317/B14(P.J.). article_processing_charge: No article_type: original author: - first_name: Duk full_name: Koh, Duk last_name: Koh - first_name: Nail full_name: Burnashev, Nail last_name: Burnashev - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Koh D, Burnashev N, Jonas PM. Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification. Journal of Physiology. 1995;486(Pt 2):305-312. doi:10.1113/jphysiol.1995.sp020813 apa: Koh, D., Burnashev, N., & Jonas, P. M. (1995). Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020813 chicago: Koh, Duk, Nail Burnashev, and Peter M Jonas. “Block of Native Ca(2+)-Permeable AMPA Receptors in Rat Brain by Intracellular Polyamines Generates Double Rectification.” Journal of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020813. ieee: D. Koh, N. Burnashev, and P. M. Jonas, “Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification,” Journal of Physiology, vol. 486, no. Pt 2. Wiley-Blackwell, pp. 305–312, 1995. ista: Koh D, Burnashev N, Jonas PM. 1995. Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification. Journal of Physiology. 486(Pt 2), 305–312. mla: Koh, Duk, et al. “Block of Native Ca(2+)-Permeable AMPA Receptors in Rat Brain by Intracellular Polyamines Generates Double Rectification.” Journal of Physiology, vol. 486, no. Pt 2, Wiley-Blackwell, 1995, pp. 305–12, doi:10.1113/jphysiol.1995.sp020813. short: D. Koh, N. Burnashev, P.M. Jonas, Journal of Physiology 486 (1995) 305–312. date_created: 2018-12-11T12:03:33Z date_published: 1995-07-15T00:00:00Z date_updated: 2022-06-27T14:53:16Z day: '15' doi: 10.1113/jphysiol.1995.sp020813 extern: '1' external_id: pmid: - '7473198' intvolume: ' 486' issue: Pt 2 language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156754/ month: '07' oa: 1 oa_version: Published Version page: 305 - 312 pmid: 1 publication: Journal of Physiology publication_identifier: issn: - 0022-3751 publication_status: published publisher: Wiley-Blackwell publist_id: '2906' quality_controlled: '1' status: public title: Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 486 year: '1995' ... --- _id: '3480' abstract: - lang: eng text: Recording of glutamate-activated currents in membrane patches was combine with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat brain slices. Analysis of AMPARs in principal neurons end interneurons of hippocampus and neocortex and in auditory relay neurons and Bergmann glial cells indicates that the GluR-B subunit in its flip version determines formation of receptors with relatively slow gating, whereas the GluR-D subunit promotes assembly of more rapidly gated receptors. The relation between Ca 2+ permeability of AMPAR channels and the relative GluR-B mRNA abundance is consistent with the dominance of this subunit in determining the Ca 2+ permeability of native receptors. The results suggest that differential expression of GluR-B and GluR-D subunit genes, as well as splicing end editing of their mRNAs, account for the differences in gating and Ca 2+ permeability of native AMPAR channels. acknowledgement: "We thank Ulla Amtmann for efficient help with the molecular analysis. We also thank M. Kaiser for technical assistance, Dr. J. G. G. Borst for advice concerning preparation of brainstem slices, and Drs. N. Spruston and G. Stuart for critically reading the manuscript. Funded in part by Bundesministerium für Forschung und Technologie grant BCT 364 AZ 321/7291 (P. H. S.) and by Deutsche Forschungsgemeinschaftgrant SFB-3171814(P. J.). J. R. P. G. and T. M. were supported by the graduate program of Molecular and Cellular Neurobiology of the University of Heidelberg. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby\r\nmarked “advertisement” in accordance with 18 USC Section 1734 solely to Indicate this fact." article_processing_charge: No article_type: original author: - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Thorsten full_name: Melcher, Thorsten last_name: Melcher - first_name: Duk full_name: Koh, Duk last_name: Koh - first_name: Bert full_name: Sakmann, Bert last_name: Sakmann - first_name: Peter full_name: Seeburg, Peter last_name: Seeburg - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Hannah full_name: Monyer, Hannah last_name: Monyer citation: ama: Geiger J, Melcher T, Koh D, et al. Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 1995;15(1):193-204. doi:10.1016/0896-6273(95)90076-4 apa: Geiger, J., Melcher, T., Koh, D., Sakmann, B., Seeburg, P., Jonas, P. M., & Monyer, H. (1995). Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(95)90076-4 chicago: Geiger, Jörg, Thorsten Melcher, Duk Koh, Bert Sakmann, Peter Seeburg, Peter M Jonas, and Hannah Monyer. “Relative Abundance of Subunit MRNAs Determines Gating and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons in Rat CNS.” Neuron. Elsevier, 1995. https://doi.org/10.1016/0896-6273(95)90076-4. ieee: J. Geiger et al., “Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS,” Neuron, vol. 15, no. 1. Elsevier, pp. 193–204, 1995. ista: Geiger J, Melcher T, Koh D, Sakmann B, Seeburg P, Jonas PM, Monyer H. 1995. Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 15(1), 193–204. mla: Geiger, Jörg, et al. “Relative Abundance of Subunit MRNAs Determines Gating and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons in Rat CNS.” Neuron, vol. 15, no. 1, Elsevier, 1995, pp. 193–204, doi:10.1016/0896-6273(95)90076-4. short: J. Geiger, T. Melcher, D. Koh, B. Sakmann, P. Seeburg, P.M. Jonas, H. Monyer, Neuron 15 (1995) 193–204. date_created: 2018-12-11T12:03:33Z date_published: 1995-07-01T00:00:00Z date_updated: 2022-06-28T07:47:09Z day: '01' doi: 10.1016/0896-6273(95)90076-4 extern: '1' external_id: pmid: - '7619522' intvolume: ' 15' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://www.sciencedirect.com/science/article/pii/0896627395900764?via%3Dihub month: '07' oa: 1 oa_version: Published Version page: 193 - 204 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier publist_id: '2907' quality_controlled: '1' scopus_import: '1' status: public title: Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 15 year: '1995' ... --- _id: '3597' article_processing_charge: No author: - first_name: Mark full_name: Kirkpatrick, Mark last_name: Kirkpatrick - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Kirkpatrick M, Barton NH. Déjà vu all over again. Nature. 1995;377:388-389. doi:10.1038/377388a0 apa: Kirkpatrick, M., & Barton, N. H. (1995). Déjà vu all over again. Nature. Nature Publishing Group. https://doi.org/10.1038/377388a0 chicago: Kirkpatrick, Mark, and Nicholas H Barton. “Déjà vu All over Again.” Nature. Nature Publishing Group, 1995. https://doi.org/10.1038/377388a0. ieee: M. Kirkpatrick and N. H. Barton, “Déjà vu all over again,” Nature, vol. 377. Nature Publishing Group, pp. 388–389, 1995. ista: Kirkpatrick M, Barton NH. 1995. Déjà vu all over again. Nature. 377, 388–389. mla: Kirkpatrick, Mark, and Nicholas H. Barton. “Déjà vu All over Again.” Nature, vol. 377, Nature Publishing Group, 1995, pp. 388–89, doi:10.1038/377388a0. short: M. Kirkpatrick, N.H. Barton, Nature 377 (1995) 388–389. date_created: 2018-12-11T12:04:09Z date_published: 1995-10-05T00:00:00Z date_updated: 2022-06-27T13:00:10Z day: '05' doi: 10.1038/377388a0 extern: '1' external_id: pmid: - '7566112 ' intvolume: ' 377' language: - iso: eng main_file_link: - url: https://www.nature.com/articles/377388a0 month: '10' oa_version: None page: 388 - 389 pmid: 1 publication: Nature publication_identifier: issn: - 0028-0836 publication_status: published publisher: Nature Publishing Group publist_id: '2786' quality_controlled: '1' status: public title: Déjà vu all over again type: review user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 377 year: '1995' ... --- _id: '3640' abstract: - lang: eng text: 'The probability of fixation of a favorable mutation is reduced if selection at other loci causes inherited variation in fitness. A general method for calculating the fixation probability of an allele that can find itself in a variety of genetic backgrounds is applied to find the effect of substitutions, fluctuating polymorphisms, and deleterious mutations in a large population. With loose linkage, r, the effects depend on the additive genetic variance in relative fitness, var(W), and act by reducing effective population size by (N/Ne) = 1 + var(W)/2r2. However, tightly linked loci can have a substantial effect not predictable from Ne. Linked deleterious mutations reduce the fixation probability of weakly favored alleles by exp (-2U/R), where U is the total mutation rate and R is the map length in Morgans. Substitutions can cause a greater reduction: an allele with advantage s < scrit = (pi 2/6) loge (S/s) [var(W)/R] is very unlikely to be fixed. (S is the advantage of the substitution impeding fixation.) Fluctuating polymorphisms at many (n) linked loci can also have a substantial effect, reducing fixation probability by exp [square root of 2Kn var(W)/R] [K = -1/E((u-u)2/uv) depending on the frequencies (u,v) at the selected polymorphisms]. Hitchhiking due to all three kinds of selection may substantially impede adaptation that depends on weakly favored alleles.' article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Barton NH. Linkage and the limits to natural selection. Genetics. 1995;140(2):821-841. doi:http://www.genetics.org/content/140/2/821.long apa: Barton, N. H. (1995). Linkage and the limits to natural selection. Genetics. Genetics Society of America. http://www.genetics.org/content/140/2/821.long chicago: Barton, Nicholas H. “Linkage and the Limits to Natural Selection.” Genetics. Genetics Society of America, 1995. http://www.genetics.org/content/140/2/821.long. ieee: N. H. Barton, “Linkage and the limits to natural selection,” Genetics, vol. 140, no. 2. Genetics Society of America, pp. 821–841, 1995. ista: Barton NH. 1995. Linkage and the limits to natural selection. Genetics. 140(2), 821–841. mla: Barton, Nicholas H. “Linkage and the Limits to Natural Selection.” Genetics, vol. 140, no. 2, Genetics Society of America, 1995, pp. 821–41, doi:http://www.genetics.org/content/140/2/821.long. short: N.H. Barton, Genetics 140 (1995) 821–841. date_created: 2018-12-11T12:04:23Z date_published: 1995-06-01T00:00:00Z date_updated: 2022-06-24T09:59:08Z day: '01' doi: http://www.genetics.org/content/140/2/821.long extern: '1' external_id: pmid: - '7498757' intvolume: ' 140' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1206655/ month: '06' oa: 1 oa_version: Published Version page: 821 - 841 pmid: 1 publication: Genetics publication_identifier: issn: - 0016-6731 publication_status: published publisher: Genetics Society of America publist_id: '2743' quality_controlled: '1' scopus_import: '1' status: public title: Linkage and the limits to natural selection type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 140 year: '1995' ... --- _id: '4028' abstract: - lang: eng text: Efficient algorithms are described for computing topological, combinatorial, and metric properties of the union of finitely many spherical balls in R(d) These algorithms are based on a simplicial complex dual to a decomposition of the union of balls using Voronoi cells, and on short inclusion-exclusion formulas derived from this complex. The algorithms are most relevant in R(3) where unions of finitely many balls are commonly used as models of molecules. acknowledgement: This work is supported by the National Science Foundation, under Grant ASC-9200301, and the Alan T. Waterman award, Grant CCR-9118874. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author and do not necessarily reflect the view of the National Science Foundation. article_processing_charge: No article_type: original author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: Edelsbrunner H. The union of balls and its dual shape. Discrete & Computational Geometry. 1995;13(1):415-440. doi:10.1007/BF02574053 apa: Edelsbrunner, H. (1995). The union of balls and its dual shape. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/BF02574053 chicago: Edelsbrunner, Herbert. “The Union of Balls and Its Dual Shape.” Discrete & Computational Geometry. Springer, 1995. https://doi.org/10.1007/BF02574053. ieee: H. Edelsbrunner, “The union of balls and its dual shape,” Discrete & Computational Geometry, vol. 13, no. 1. Springer, pp. 415–440, 1995. ista: Edelsbrunner H. 1995. The union of balls and its dual shape. Discrete & Computational Geometry. 13(1), 415–440. mla: Edelsbrunner, Herbert. “The Union of Balls and Its Dual Shape.” Discrete & Computational Geometry, vol. 13, no. 1, Springer, 1995, pp. 415–40, doi:10.1007/BF02574053. short: H. Edelsbrunner, Discrete & Computational Geometry 13 (1995) 415–440. date_created: 2018-12-11T12:06:31Z date_published: 1995-12-01T00:00:00Z date_updated: 2022-06-27T08:14:48Z day: '01' doi: 10.1007/BF02574053 extern: '1' intvolume: ' 13' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://link.springer.com/article/10.1007/BF02574053 month: '12' oa: 1 oa_version: Published Version page: 415 - 440 publication: Discrete & Computational Geometry publication_identifier: issn: - 0179-5376 publication_status: published publisher: Springer publist_id: '2095' quality_controlled: '1' scopus_import: '1' status: public title: The union of balls and its dual shape type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 13 year: '1995' ... --- _id: '4029' abstract: - lang: eng text: A general and direct method for computing the Betti numbers of a finite simplicial complex in Bd is given. This method is complete for d less than or equal to 3, where versions of this method run in time O(n alpha(n)) and O(n), n the number of simplices. An implementation of the algorithm is applied to alpha shapes, which is a novel geometric modeling tool. acknowledgement: This work is supported by the National Science Foundation under grant ASC-9200301 and the Alan T. Waterman award, grant CCR-9118874. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the National Science Foundation. article_processing_charge: No article_type: original author: - first_name: Cecil full_name: Delfinado, Cecil last_name: Delfinado - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: Delfinado C, Edelsbrunner H. An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere. Computer Aided Geometric Design. 1995;12(7):771-784. doi:10.1016/0167-8396(95)00016-Y apa: Delfinado, C., & Edelsbrunner, H. (1995). An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere. Computer Aided Geometric Design. Elsevier. https://doi.org/10.1016/0167-8396(95)00016-Y chicago: Delfinado, Cecil, and Herbert Edelsbrunner. “An Incremental Algorithm for Betti Numbers of Simplicial Complexes on the 3-Sphere.” Computer Aided Geometric Design. Elsevier, 1995. https://doi.org/10.1016/0167-8396(95)00016-Y. ieee: C. Delfinado and H. Edelsbrunner, “An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere,” Computer Aided Geometric Design, vol. 12, no. 7. Elsevier, pp. 771–784, 1995. ista: Delfinado C, Edelsbrunner H. 1995. An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere. Computer Aided Geometric Design. 12(7), 771–784. mla: Delfinado, Cecil, and Herbert Edelsbrunner. “An Incremental Algorithm for Betti Numbers of Simplicial Complexes on the 3-Sphere.” Computer Aided Geometric Design, vol. 12, no. 7, Elsevier, 1995, pp. 771–84, doi:10.1016/0167-8396(95)00016-Y. short: C. Delfinado, H. Edelsbrunner, Computer Aided Geometric Design 12 (1995) 771–784. date_created: 2018-12-11T12:06:32Z date_published: 1995-11-01T00:00:00Z date_updated: 2022-06-24T09:49:32Z day: '01' doi: 10.1016/0167-8396(95)00016-Y extern: '1' intvolume: ' 12' issue: '7' language: - iso: eng main_file_link: - url: https://www.sciencedirect.com/science/article/pii/016783969500016Y?via%3Dihub month: '11' oa_version: None page: 771 - 784 publication: Computer Aided Geometric Design publication_identifier: issn: - 0167-8396 publication_status: published publisher: Elsevier publist_id: '2096' quality_controlled: '1' scopus_import: '1' status: public title: An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '1995' ... --- _id: '4297' abstract: - lang: eng text: The F5 (2n = 34) and FM2 (2n = 44-46) chromosome races of the Sceloporus grammicus complex form a parapatric hybrid zone in the Mexican state of Hidalgo, characterized by steep concordant clines among three diagnostic chromosome markers across a straight-line distance of about 2 km. Here, we show that this zone is actually structured into local patches in which hybridization extends over an extremely irregular front. The distribution of hybrid-index (HI) scores across the transect reveals some hybridization at almost all localities mapped in a central 7 km x 3 km area. Pooling the central samples produces both a strong heterozygote deficit for all diagnostic markers and strong linkage disequilibria between all pairwise combinations of these (unlinked) markers. Moreover, a highly significant association exists between the habitat on which each individual was caught and its karyotype (F5 chromosomes are more likely to be found on oak). Analysis of genotype frequencies over a range of spatial scales shows that there is no significant heterozygote deficit or habitat association within local areas of less than about 200 m; however, there is significant linkage disequilibrium over the smallest scales (R = D (pquv)1/2 = 0.29, support limits, 0.18-0.36) over 100 m. These patterns suggest that lizards mate and choose habitats randomly within local patches. This conclusion is supported by mark-recapture estimates of dispersal (≈ 80 m in a generation) and by inference of matings from embryo and maternal karyotypes. Closer examination of the two-dimensional pattern reveals a convoluted cline for all three markers, with a width of 830 m (support limits 770 m-930 m). This cline width, combined with the strength of local linkage disequilibrium, implies a dispersal rate of σ = 160 m in a generation and an effective selection pressure of 30% on each chromosome marker. The proportion of inviable embryos is greater in females from the center of the hybrid zone; this is caused by effects associated with both karyotype and location. The hybrid zone is likely to be maintained by selection against chromosomal heterozygotes, by other kinds of selection against hybrids, and by selection adapting the chromosome races to different habitats. The structure of the contact may be caused by both random drift and by selection in relation to habitat. acknowledgement: For field assistance in collecting and mapping of the zone, we thank E. Arevalo, I. Goyenechea, D. Hutchison, M. Man- cilia, F. Mendoza, D. Mink, and J. and H. Sites. The mark- recapture work was carried out by M. Mancilla, F Mendoza, and A. Gonzales. J.W.S. also thanks T. Hinckley and D. Ste­vens of the Brigham Young University Department of Ge­ography for lessons in surveying and map making and use of the field equipment and planimeter. B. Nürnberger pro­vided the digitized coordinates for individual lizards and as­sisted with the analysis of spatial structure and viability. B. Nürnberger, C. MacCallum, J. Mallet, and J. Searle also pro­vided helpful comments on the manuscript. This work was supported by National Science Foundation grants BSR 85- 09092 and 88-22751 to J.W.S., and grants from the Science and Engineering Research Council (GR/H09929) and Natural Environment Research Council (GR3/8002) and the DarwinTrust to N.H.B. The Mexican agency Secretaria de DesarrolloUrbano y Ecologia (now Secretaria de Desarrollo Social) kindly provided scientific collecting permits (to E. Arévalo) for field work in 1989 and 1991. article_processing_charge: No article_type: original author: - first_name: Jack full_name: Sites, Jack last_name: Sites - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Kent full_name: Reed, Kent last_name: Reed citation: ama: Sites J, Barton NH, Reed K. The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico. Evolution. 1995;49(1):9-36. doi:10.1111/j.1558-5646.1995.tb05955.x apa: Sites, J., Barton, N. H., & Reed, K. (1995). The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1995.tb05955.x chicago: Sites, Jack, Nicholas H Barton, and Kent Reed. “The Genetic Structure of a Mosaic Hybrid Zone between Two Chromosome Races of the Sceloporus Grammicus Complex (Sauria, Phrynosomatidae) in Central Mexico.” Evolution. Wiley-Blackwell, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb05955.x. ieee: J. Sites, N. H. Barton, and K. Reed, “The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico,” Evolution, vol. 49, no. 1. Wiley-Blackwell, pp. 9–36, 1995. ista: Sites J, Barton NH, Reed K. 1995. The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico. Evolution. 49(1), 9–36. mla: Sites, Jack, et al. “The Genetic Structure of a Mosaic Hybrid Zone between Two Chromosome Races of the Sceloporus Grammicus Complex (Sauria, Phrynosomatidae) in Central Mexico.” Evolution, vol. 49, no. 1, Wiley-Blackwell, 1995, pp. 9–36, doi:10.1111/j.1558-5646.1995.tb05955.x. short: J. Sites, N.H. Barton, K. Reed, Evolution 49 (1995) 9–36. date_created: 2018-12-11T12:08:06Z date_published: 1995-02-01T00:00:00Z date_updated: 2022-06-13T09:24:40Z day: '01' doi: 10.1111/j.1558-5646.1995.tb05955.x extern: '1' external_id: pmid: - '28593667' intvolume: ' 49' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1995.tb05955.x month: '02' oa: 1 oa_version: Published Version page: 9 - 36 pmid: 1 publication: Evolution publication_identifier: issn: - 0014-3820 publication_status: published publisher: Wiley-Blackwell publist_id: '1779' quality_controlled: '1' scopus_import: '1' status: public title: The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '1995' ... --- _id: '4296' abstract: - lang: eng text: Three replicate lines of Drosophila melanogaster were cultured at each of two temperatures (16.5⚬C and 25⚬C) in population cages for 4 yr. The lifespans of both sexes and the fecundity and fertility of the females were then measured at both experimental temperatures. The characters showed evidence of adaptation; flies of both sexes from each selection regime showed higher longevity, and females showed higher fecundity and fertility, than flies from the other selection regime when they were tested at the experimental temperature at which they had evolved. Calculation of intrinsic rates of increase under different assumptions about the rate of population increase showed that the difference between the lines from the two selection regimes became less the higher the rate of population increase, because the lines were more similar in early adulthood than they were later. Despite the increased adaptation of the low-temperature lines to the low temperature, like the high temperature lines they produced progeny at a higher rate at the higher temperature. The lines may have independently evolved adaptations to their respective thermal regimes during the experiment, or there may have been a trade-off between adaptation to the two temperatures, or mutation pressure may have lowered adaptation to the temperature that the flies no longer encountered. acknowledgement: We thank Natural Environment Research Council and the Royal Society for financial support. article_processing_charge: No article_type: original author: - first_name: Linda full_name: Partridge, Linda last_name: Partridge - first_name: Brian full_name: Barrie, Brian last_name: Barrie - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Kevin full_name: Fowler, Kevin last_name: Fowler - first_name: Vernon full_name: French, Vernon last_name: French citation: ama: Partridge L, Barrie B, Barton NH, Fowler K, French V. Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature. Evolution. 1995;49(3):538-544. doi:10.1111/j.1558-5646.1995.tb02285.x apa: Partridge, L., Barrie, B., Barton, N. H., Fowler, K., & French, V. (1995). Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1995.tb02285.x chicago: Partridge, Linda, Brian Barrie, Nicholas H Barton, Kevin Fowler, and Vernon French. “Rapid Laboratory Evolution of Adult Life History Traits in Drosophila Melanogaster in Response to Temperature.” Evolution. Wiley-Blackwell, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb02285.x. ieee: L. Partridge, B. Barrie, N. H. Barton, K. Fowler, and V. French, “Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature,” Evolution, vol. 49, no. 3. Wiley-Blackwell, pp. 538–544, 1995. ista: Partridge L, Barrie B, Barton NH, Fowler K, French V. 1995. Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature. Evolution. 49(3), 538–544. mla: Partridge, Linda, et al. “Rapid Laboratory Evolution of Adult Life History Traits in Drosophila Melanogaster in Response to Temperature.” Evolution, vol. 49, no. 3, Wiley-Blackwell, 1995, pp. 538–44, doi:10.1111/j.1558-5646.1995.tb02285.x. short: L. Partridge, B. Barrie, N.H. Barton, K. Fowler, V. French, Evolution 49 (1995) 538–544. date_created: 2018-12-11T12:08:06Z date_published: 1995-06-01T00:00:00Z date_updated: 2022-06-13T08:42:11Z day: '01' doi: 10.1111/j.1558-5646.1995.tb02285.x extern: '1' external_id: pmid: - '28565092 ' intvolume: ' 49' issue: '3' language: - iso: eng main_file_link: - open_access: '1' url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1995.tb02285.x month: '06' oa: 1 oa_version: Published Version page: 538 - 544 pmid: 1 publication: Evolution publication_identifier: issn: - 0014-3820 publication_status: published publisher: Wiley-Blackwell publist_id: '1778' quality_controlled: '1' scopus_import: '1' status: public title: Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '1995' ... --- _id: '4298' article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Barton NH. Appendix to “A simulation study of multilocus clines” by S J E Baird. Evolution. 1995;49(6):1038-1045. doi:10.1111/j.1558-5646.1995.tb04431.x apa: Barton, N. H. (1995). Appendix to “A simulation study of multilocus clines” by S J E Baird. Evolution. Wiley. https://doi.org/10.1111/j.1558-5646.1995.tb04431.x chicago: Barton, Nicholas H. “Appendix to ‘A Simulation Study of Multilocus Clines’ by S J E Baird.” Evolution. Wiley, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb04431.x. ieee: N. H. Barton, “Appendix to ‘A simulation study of multilocus clines’ by S J E Baird,” Evolution, vol. 49, no. 6. Wiley, pp. 1038–1045, 1995. ista: Barton NH. 1995. Appendix to ‘A simulation study of multilocus clines’ by S J E Baird. Evolution. 49(6), 1038–1045. mla: Barton, Nicholas H. “Appendix to ‘A Simulation Study of Multilocus Clines’ by S J E Baird.” Evolution, vol. 49, no. 6, Wiley, 1995, pp. 1038–45, doi:10.1111/j.1558-5646.1995.tb04431.x. short: N.H. Barton, Evolution 49 (1995) 1038–1045. date_created: 2018-12-11T12:08:07Z date_published: 1995-12-01T00:00:00Z date_updated: 2022-06-28T07:47:30Z day: '01' doi: 10.1111/j.1558-5646.1995.tb04431.x extern: '1' intvolume: ' 49' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1111/j.1558-5646.1995.tb04431.x month: '12' oa: 1 oa_version: Published Version page: 1038 - 1045 publication: Evolution publication_identifier: issn: - 1558-5646 publication_status: published publisher: Wiley publist_id: '1773' quality_controlled: '1' status: public title: Appendix to "A simulation study of multilocus clines" by S J E Baird type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '1995' ... --- _id: '4428' abstract: - lang: eng text: "Hybrid systems are real-time systems that react to both discrete and continuous activities (such as analog signals, time, temperature, and speed). Typical examples of hybrid systems are embedded systems, timing-based communication protocols, and digital circuits at the transistor level. Due to the rapid development of microprocessor technology, hybrid systems directly control much of what we depend on in our daily lives. Consequently, the formal specification and verification of hybrid systems has become an active area of research. This dissertation presents the first general framework for the formal specification and verification of hybrid systems, as well as the first hybrid-system analysis tool--HyTech. The framework consists of a graphical finite-state-machine-like language for modeling hybrid systems, a temporal logic for modeling the requirements of hybrid systems, and a computer procedure that verifies modeled hybrid systems against modeled requirements. The tool HyTech is the implementation of the framework using C++ and Mathematica.\r\n\r\nMore specifically, our hybrid-system modeling language, Hybrid Automata, is an extension of timed automata with discrete and continuous variables whose dynamics are governed by differential equations. Our requirement modeling language, ICTL, is a branching-time temporal logic, and is an extension of TCTL with stop-watch variables. Our verification procedure is a symbolic model-checking procedure that verifies linear hybrid automata against ICTL formulas. To make HyTech more efficient and effective, we use model-checking strategies and abstract operators that can expedite the verification process. To enable HyTech to verify nonlinear hybrid automata, we introduce two translations from nonlinear hybrid automata to linear hybrid automata. We have applied HyTech to analyze more than 30 hybrid-system benchmarks. In this dissertation, we present the application of HyTech to three nontrivial hybrid systems taken from the literature." article_processing_charge: No author: - first_name: Pei full_name: Ho, Pei last_name: Ho citation: ama: Ho P. Automatic analysis of hybrid systems. 1995:1-188. apa: Ho, P. (1995). Automatic analysis of hybrid systems. Cornell University. chicago: Ho, Pei. “Automatic Analysis of Hybrid Systems.” Cornell University, 1995. ieee: P. Ho, “Automatic analysis of hybrid systems,” Cornell University, 1995. ista: Ho P. 1995. Automatic analysis of hybrid systems. Cornell University. mla: Ho, Pei. Automatic Analysis of Hybrid Systems. Cornell University, 1995, pp. 1–188. short: P. Ho, Automatic Analysis of Hybrid Systems, Cornell University, 1995. date_created: 2018-12-11T12:08:48Z date_published: 1995-08-01T00:00:00Z date_updated: 2022-06-28T07:30:34Z day: '01' degree_awarded: PhD extern: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://hdl.handle.net/1813/7193 month: '08' oa: 1 oa_version: Published Version page: 1 - 188 publication_status: published publisher: Cornell University publist_id: '304' status: public supervisor: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 title: Automatic analysis of hybrid systems type: dissertation user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '1995' ...