--- _id: '3481' abstract: - lang: eng text: 1. The influence of intracellular factors on current rectification of different subtypes of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) was studied in rat brain slices by combining fast application of glutamate with patch pipette perfusion. 2. The peak current-voltage (I-V) relation of the AMPARs expressed in Bergmann glial cells of cerebellum and dentate gyrus (DG) basket cells of hippocampus was weakly rectifying in outside-out patches and nystatin-perforated vesicles, but showed a doubly rectifying shape with a region of reduced slope between 0 and +40 mV in nucleated patches. The I-V relation of AMPARs expressed in hippocampal CA3 pyramidal neurones was linear in all recording configurations. 3. Intracellular application of 2.5 μM spermine, a naturally occurring polyamine, blocked outward currents in outside-oat patches from Bergmann glial cells and DG basket cells in a voltage-dependent manner, generating I-V relations with a doubly rectifying shape which were similar to those recorded in nucleated patches. AMPARs in CA3 pyramidal cell patches were unaffected by 25 μM spermine. 4. The half-maximal blocking concentration of spermine at +40 mV was 0.3 μM in Bergmann glial cell patches and 1.5 μM in DG basket cell patches, whereas it was much higher (≥ 100 μM) for CA3 pyramidal. cell patches. Spermidine also affected current rectification, but with lower affinity. The block of outward current by polyamines following voltage jumps developed within < 0.5 ms. 5. We conclude that current rectification, rather than being an intrinsic property of the Ca2+ permeable AMPAR channel, is generated by polyamine block. acknowledgement: We thank Dr B.Sakmann, Dr V.Witzemann, J.Geiger, and A.Roth for helpful discussions and Dr D.Feldmeyer and Dr A.Villarroel for reading the manuscript. We also thank M.Kaiser for technical and H.Spiegel for secretarial assistance. Supported by DFG grant SFB-317/B14(P.J.). article_processing_charge: No article_type: original author: - first_name: Duk full_name: Koh, Duk last_name: Koh - first_name: Nail full_name: Burnashev, Nail last_name: Burnashev - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Koh D, Burnashev N, Jonas PM. Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification. Journal of Physiology. 1995;486(Pt 2):305-312. doi:10.1113/jphysiol.1995.sp020813 apa: Koh, D., Burnashev, N., & Jonas, P. M. (1995). Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020813 chicago: Koh, Duk, Nail Burnashev, and Peter M Jonas. “Block of Native Ca(2+)-Permeable AMPA Receptors in Rat Brain by Intracellular Polyamines Generates Double Rectification.” Journal of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020813. ieee: D. Koh, N. Burnashev, and P. M. Jonas, “Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification,” Journal of Physiology, vol. 486, no. Pt 2. Wiley-Blackwell, pp. 305–312, 1995. ista: Koh D, Burnashev N, Jonas PM. 1995. Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification. Journal of Physiology. 486(Pt 2), 305–312. mla: Koh, Duk, et al. “Block of Native Ca(2+)-Permeable AMPA Receptors in Rat Brain by Intracellular Polyamines Generates Double Rectification.” Journal of Physiology, vol. 486, no. Pt 2, Wiley-Blackwell, 1995, pp. 305–12, doi:10.1113/jphysiol.1995.sp020813. short: D. Koh, N. Burnashev, P.M. Jonas, Journal of Physiology 486 (1995) 305–312. date_created: 2018-12-11T12:03:33Z date_published: 1995-07-15T00:00:00Z date_updated: 2022-06-27T14:53:16Z day: '15' doi: 10.1113/jphysiol.1995.sp020813 extern: '1' external_id: pmid: - '7473198' intvolume: ' 486' issue: Pt 2 language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156754/ month: '07' oa: 1 oa_version: Published Version page: 305 - 312 pmid: 1 publication: Journal of Physiology publication_identifier: issn: - 0022-3751 publication_status: published publisher: Wiley-Blackwell publist_id: '2906' quality_controlled: '1' status: public title: Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 486 year: '1995' ... --- _id: '3480' abstract: - lang: eng text: Recording of glutamate-activated currents in membrane patches was combine with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat brain slices. Analysis of AMPARs in principal neurons end interneurons of hippocampus and neocortex and in auditory relay neurons and Bergmann glial cells indicates that the GluR-B subunit in its flip version determines formation of receptors with relatively slow gating, whereas the GluR-D subunit promotes assembly of more rapidly gated receptors. The relation between Ca 2+ permeability of AMPAR channels and the relative GluR-B mRNA abundance is consistent with the dominance of this subunit in determining the Ca 2+ permeability of native receptors. The results suggest that differential expression of GluR-B and GluR-D subunit genes, as well as splicing end editing of their mRNAs, account for the differences in gating and Ca 2+ permeability of native AMPAR channels. acknowledgement: "We thank Ulla Amtmann for efficient help with the molecular analysis. We also thank M. Kaiser for technical assistance, Dr. J. G. G. Borst for advice concerning preparation of brainstem slices, and Drs. N. Spruston and G. Stuart for critically reading the manuscript. Funded in part by Bundesministerium für Forschung und Technologie grant BCT 364 AZ 321/7291 (P. H. S.) and by Deutsche Forschungsgemeinschaftgrant SFB-3171814(P. J.). J. R. P. G. and T. M. were supported by the graduate program of Molecular and Cellular Neurobiology of the University of Heidelberg. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby\r\nmarked “advertisement” in accordance with 18 USC Section 1734 solely to Indicate this fact." article_processing_charge: No article_type: original author: - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Thorsten full_name: Melcher, Thorsten last_name: Melcher - first_name: Duk full_name: Koh, Duk last_name: Koh - first_name: Bert full_name: Sakmann, Bert last_name: Sakmann - first_name: Peter full_name: Seeburg, Peter last_name: Seeburg - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Hannah full_name: Monyer, Hannah last_name: Monyer citation: ama: Geiger J, Melcher T, Koh D, et al. Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 1995;15(1):193-204. doi:10.1016/0896-6273(95)90076-4 apa: Geiger, J., Melcher, T., Koh, D., Sakmann, B., Seeburg, P., Jonas, P. M., & Monyer, H. (1995). Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(95)90076-4 chicago: Geiger, Jörg, Thorsten Melcher, Duk Koh, Bert Sakmann, Peter Seeburg, Peter M Jonas, and Hannah Monyer. “Relative Abundance of Subunit MRNAs Determines Gating and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons in Rat CNS.” Neuron. Elsevier, 1995. https://doi.org/10.1016/0896-6273(95)90076-4. ieee: J. Geiger et al., “Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS,” Neuron, vol. 15, no. 1. Elsevier, pp. 193–204, 1995. ista: Geiger J, Melcher T, Koh D, Sakmann B, Seeburg P, Jonas PM, Monyer H. 1995. Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 15(1), 193–204. mla: Geiger, Jörg, et al. “Relative Abundance of Subunit MRNAs Determines Gating and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons in Rat CNS.” Neuron, vol. 15, no. 1, Elsevier, 1995, pp. 193–204, doi:10.1016/0896-6273(95)90076-4. short: J. Geiger, T. Melcher, D. Koh, B. Sakmann, P. Seeburg, P.M. Jonas, H. Monyer, Neuron 15 (1995) 193–204. date_created: 2018-12-11T12:03:33Z date_published: 1995-07-01T00:00:00Z date_updated: 2022-06-28T07:47:09Z day: '01' doi: 10.1016/0896-6273(95)90076-4 extern: '1' external_id: pmid: - '7619522' intvolume: ' 15' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://www.sciencedirect.com/science/article/pii/0896627395900764?via%3Dihub month: '07' oa: 1 oa_version: Published Version page: 193 - 204 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier publist_id: '2907' quality_controlled: '1' scopus_import: '1' status: public title: Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 15 year: '1995' ... --- _id: '3597' article_processing_charge: No author: - first_name: Mark full_name: Kirkpatrick, Mark last_name: Kirkpatrick - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Kirkpatrick M, Barton NH. Déjà vu all over again. Nature. 1995;377:388-389. doi:10.1038/377388a0 apa: Kirkpatrick, M., & Barton, N. H. (1995). Déjà vu all over again. Nature. Nature Publishing Group. https://doi.org/10.1038/377388a0 chicago: Kirkpatrick, Mark, and Nicholas H Barton. “Déjà vu All over Again.” Nature. Nature Publishing Group, 1995. https://doi.org/10.1038/377388a0. ieee: M. Kirkpatrick and N. H. Barton, “Déjà vu all over again,” Nature, vol. 377. Nature Publishing Group, pp. 388–389, 1995. ista: Kirkpatrick M, Barton NH. 1995. Déjà vu all over again. Nature. 377, 388–389. mla: Kirkpatrick, Mark, and Nicholas H. Barton. “Déjà vu All over Again.” Nature, vol. 377, Nature Publishing Group, 1995, pp. 388–89, doi:10.1038/377388a0. short: M. Kirkpatrick, N.H. Barton, Nature 377 (1995) 388–389. date_created: 2018-12-11T12:04:09Z date_published: 1995-10-05T00:00:00Z date_updated: 2022-06-27T13:00:10Z day: '05' doi: 10.1038/377388a0 extern: '1' external_id: pmid: - '7566112 ' intvolume: ' 377' language: - iso: eng main_file_link: - url: https://www.nature.com/articles/377388a0 month: '10' oa_version: None page: 388 - 389 pmid: 1 publication: Nature publication_identifier: issn: - 0028-0836 publication_status: published publisher: Nature Publishing Group publist_id: '2786' quality_controlled: '1' status: public title: Déjà vu all over again type: review user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 377 year: '1995' ... --- _id: '3640' abstract: - lang: eng text: 'The probability of fixation of a favorable mutation is reduced if selection at other loci causes inherited variation in fitness. A general method for calculating the fixation probability of an allele that can find itself in a variety of genetic backgrounds is applied to find the effect of substitutions, fluctuating polymorphisms, and deleterious mutations in a large population. With loose linkage, r, the effects depend on the additive genetic variance in relative fitness, var(W), and act by reducing effective population size by (N/Ne) = 1 + var(W)/2r2. However, tightly linked loci can have a substantial effect not predictable from Ne. Linked deleterious mutations reduce the fixation probability of weakly favored alleles by exp (-2U/R), where U is the total mutation rate and R is the map length in Morgans. Substitutions can cause a greater reduction: an allele with advantage s < scrit = (pi 2/6) loge (S/s) [var(W)/R] is very unlikely to be fixed. (S is the advantage of the substitution impeding fixation.) Fluctuating polymorphisms at many (n) linked loci can also have a substantial effect, reducing fixation probability by exp [square root of 2Kn var(W)/R] [K = -1/E((u-u)2/uv) depending on the frequencies (u,v) at the selected polymorphisms]. Hitchhiking due to all three kinds of selection may substantially impede adaptation that depends on weakly favored alleles.' article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Barton NH. Linkage and the limits to natural selection. Genetics. 1995;140(2):821-841. doi:http://www.genetics.org/content/140/2/821.long apa: Barton, N. H. (1995). Linkage and the limits to natural selection. Genetics. Genetics Society of America. http://www.genetics.org/content/140/2/821.long chicago: Barton, Nicholas H. “Linkage and the Limits to Natural Selection.” Genetics. Genetics Society of America, 1995. http://www.genetics.org/content/140/2/821.long. ieee: N. H. Barton, “Linkage and the limits to natural selection,” Genetics, vol. 140, no. 2. Genetics Society of America, pp. 821–841, 1995. ista: Barton NH. 1995. Linkage and the limits to natural selection. Genetics. 140(2), 821–841. mla: Barton, Nicholas H. “Linkage and the Limits to Natural Selection.” Genetics, vol. 140, no. 2, Genetics Society of America, 1995, pp. 821–41, doi:http://www.genetics.org/content/140/2/821.long. short: N.H. Barton, Genetics 140 (1995) 821–841. date_created: 2018-12-11T12:04:23Z date_published: 1995-06-01T00:00:00Z date_updated: 2022-06-24T09:59:08Z day: '01' doi: http://www.genetics.org/content/140/2/821.long extern: '1' external_id: pmid: - '7498757' intvolume: ' 140' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1206655/ month: '06' oa: 1 oa_version: Published Version page: 821 - 841 pmid: 1 publication: Genetics publication_identifier: issn: - 0016-6731 publication_status: published publisher: Genetics Society of America publist_id: '2743' quality_controlled: '1' scopus_import: '1' status: public title: Linkage and the limits to natural selection type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 140 year: '1995' ... --- _id: '4028' abstract: - lang: eng text: Efficient algorithms are described for computing topological, combinatorial, and metric properties of the union of finitely many spherical balls in R(d) These algorithms are based on a simplicial complex dual to a decomposition of the union of balls using Voronoi cells, and on short inclusion-exclusion formulas derived from this complex. The algorithms are most relevant in R(3) where unions of finitely many balls are commonly used as models of molecules. acknowledgement: This work is supported by the National Science Foundation, under Grant ASC-9200301, and the Alan T. Waterman award, Grant CCR-9118874. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author and do not necessarily reflect the view of the National Science Foundation. article_processing_charge: No article_type: original author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: Edelsbrunner H. The union of balls and its dual shape. Discrete & Computational Geometry. 1995;13(1):415-440. doi:10.1007/BF02574053 apa: Edelsbrunner, H. (1995). The union of balls and its dual shape. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/BF02574053 chicago: Edelsbrunner, Herbert. “The Union of Balls and Its Dual Shape.” Discrete & Computational Geometry. Springer, 1995. https://doi.org/10.1007/BF02574053. ieee: H. Edelsbrunner, “The union of balls and its dual shape,” Discrete & Computational Geometry, vol. 13, no. 1. Springer, pp. 415–440, 1995. ista: Edelsbrunner H. 1995. The union of balls and its dual shape. Discrete & Computational Geometry. 13(1), 415–440. mla: Edelsbrunner, Herbert. “The Union of Balls and Its Dual Shape.” Discrete & Computational Geometry, vol. 13, no. 1, Springer, 1995, pp. 415–40, doi:10.1007/BF02574053. short: H. Edelsbrunner, Discrete & Computational Geometry 13 (1995) 415–440. date_created: 2018-12-11T12:06:31Z date_published: 1995-12-01T00:00:00Z date_updated: 2022-06-27T08:14:48Z day: '01' doi: 10.1007/BF02574053 extern: '1' intvolume: ' 13' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://link.springer.com/article/10.1007/BF02574053 month: '12' oa: 1 oa_version: Published Version page: 415 - 440 publication: Discrete & Computational Geometry publication_identifier: issn: - 0179-5376 publication_status: published publisher: Springer publist_id: '2095' quality_controlled: '1' scopus_import: '1' status: public title: The union of balls and its dual shape type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 13 year: '1995' ... --- _id: '4029' abstract: - lang: eng text: A general and direct method for computing the Betti numbers of a finite simplicial complex in Bd is given. This method is complete for d less than or equal to 3, where versions of this method run in time O(n alpha(n)) and O(n), n the number of simplices. An implementation of the algorithm is applied to alpha shapes, which is a novel geometric modeling tool. acknowledgement: This work is supported by the National Science Foundation under grant ASC-9200301 and the Alan T. Waterman award, grant CCR-9118874. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the National Science Foundation. article_processing_charge: No article_type: original author: - first_name: Cecil full_name: Delfinado, Cecil last_name: Delfinado - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: Delfinado C, Edelsbrunner H. An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere. Computer Aided Geometric Design. 1995;12(7):771-784. doi:10.1016/0167-8396(95)00016-Y apa: Delfinado, C., & Edelsbrunner, H. (1995). An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere. Computer Aided Geometric Design. Elsevier. https://doi.org/10.1016/0167-8396(95)00016-Y chicago: Delfinado, Cecil, and Herbert Edelsbrunner. “An Incremental Algorithm for Betti Numbers of Simplicial Complexes on the 3-Sphere.” Computer Aided Geometric Design. Elsevier, 1995. https://doi.org/10.1016/0167-8396(95)00016-Y. ieee: C. Delfinado and H. Edelsbrunner, “An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere,” Computer Aided Geometric Design, vol. 12, no. 7. Elsevier, pp. 771–784, 1995. ista: Delfinado C, Edelsbrunner H. 1995. An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere. Computer Aided Geometric Design. 12(7), 771–784. mla: Delfinado, Cecil, and Herbert Edelsbrunner. “An Incremental Algorithm for Betti Numbers of Simplicial Complexes on the 3-Sphere.” Computer Aided Geometric Design, vol. 12, no. 7, Elsevier, 1995, pp. 771–84, doi:10.1016/0167-8396(95)00016-Y. short: C. Delfinado, H. Edelsbrunner, Computer Aided Geometric Design 12 (1995) 771–784. date_created: 2018-12-11T12:06:32Z date_published: 1995-11-01T00:00:00Z date_updated: 2022-06-24T09:49:32Z day: '01' doi: 10.1016/0167-8396(95)00016-Y extern: '1' intvolume: ' 12' issue: '7' language: - iso: eng main_file_link: - url: https://www.sciencedirect.com/science/article/pii/016783969500016Y?via%3Dihub month: '11' oa_version: None page: 771 - 784 publication: Computer Aided Geometric Design publication_identifier: issn: - 0167-8396 publication_status: published publisher: Elsevier publist_id: '2096' quality_controlled: '1' scopus_import: '1' status: public title: An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '1995' ... --- _id: '4297' abstract: - lang: eng text: The F5 (2n = 34) and FM2 (2n = 44-46) chromosome races of the Sceloporus grammicus complex form a parapatric hybrid zone in the Mexican state of Hidalgo, characterized by steep concordant clines among three diagnostic chromosome markers across a straight-line distance of about 2 km. Here, we show that this zone is actually structured into local patches in which hybridization extends over an extremely irregular front. The distribution of hybrid-index (HI) scores across the transect reveals some hybridization at almost all localities mapped in a central 7 km x 3 km area. Pooling the central samples produces both a strong heterozygote deficit for all diagnostic markers and strong linkage disequilibria between all pairwise combinations of these (unlinked) markers. Moreover, a highly significant association exists between the habitat on which each individual was caught and its karyotype (F5 chromosomes are more likely to be found on oak). Analysis of genotype frequencies over a range of spatial scales shows that there is no significant heterozygote deficit or habitat association within local areas of less than about 200 m; however, there is significant linkage disequilibrium over the smallest scales (R = D (pquv)1/2 = 0.29, support limits, 0.18-0.36) over 100 m. These patterns suggest that lizards mate and choose habitats randomly within local patches. This conclusion is supported by mark-recapture estimates of dispersal (≈ 80 m in a generation) and by inference of matings from embryo and maternal karyotypes. Closer examination of the two-dimensional pattern reveals a convoluted cline for all three markers, with a width of 830 m (support limits 770 m-930 m). This cline width, combined with the strength of local linkage disequilibrium, implies a dispersal rate of σ = 160 m in a generation and an effective selection pressure of 30% on each chromosome marker. The proportion of inviable embryos is greater in females from the center of the hybrid zone; this is caused by effects associated with both karyotype and location. The hybrid zone is likely to be maintained by selection against chromosomal heterozygotes, by other kinds of selection against hybrids, and by selection adapting the chromosome races to different habitats. The structure of the contact may be caused by both random drift and by selection in relation to habitat. acknowledgement: For field assistance in collecting and mapping of the zone, we thank E. Arevalo, I. Goyenechea, D. Hutchison, M. Man- cilia, F. Mendoza, D. Mink, and J. and H. Sites. The mark- recapture work was carried out by M. Mancilla, F Mendoza, and A. Gonzales. J.W.S. also thanks T. Hinckley and D. Ste­vens of the Brigham Young University Department of Ge­ography for lessons in surveying and map making and use of the field equipment and planimeter. B. Nürnberger pro­vided the digitized coordinates for individual lizards and as­sisted with the analysis of spatial structure and viability. B. Nürnberger, C. MacCallum, J. Mallet, and J. Searle also pro­vided helpful comments on the manuscript. This work was supported by National Science Foundation grants BSR 85- 09092 and 88-22751 to J.W.S., and grants from the Science and Engineering Research Council (GR/H09929) and Natural Environment Research Council (GR3/8002) and the DarwinTrust to N.H.B. The Mexican agency Secretaria de DesarrolloUrbano y Ecologia (now Secretaria de Desarrollo Social) kindly provided scientific collecting permits (to E. Arévalo) for field work in 1989 and 1991. article_processing_charge: No article_type: original author: - first_name: Jack full_name: Sites, Jack last_name: Sites - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Kent full_name: Reed, Kent last_name: Reed citation: ama: Sites J, Barton NH, Reed K. The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico. Evolution. 1995;49(1):9-36. doi:10.1111/j.1558-5646.1995.tb05955.x apa: Sites, J., Barton, N. H., & Reed, K. (1995). The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1995.tb05955.x chicago: Sites, Jack, Nicholas H Barton, and Kent Reed. “The Genetic Structure of a Mosaic Hybrid Zone between Two Chromosome Races of the Sceloporus Grammicus Complex (Sauria, Phrynosomatidae) in Central Mexico.” Evolution. Wiley-Blackwell, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb05955.x. ieee: J. Sites, N. H. Barton, and K. Reed, “The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico,” Evolution, vol. 49, no. 1. Wiley-Blackwell, pp. 9–36, 1995. ista: Sites J, Barton NH, Reed K. 1995. The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico. Evolution. 49(1), 9–36. mla: Sites, Jack, et al. “The Genetic Structure of a Mosaic Hybrid Zone between Two Chromosome Races of the Sceloporus Grammicus Complex (Sauria, Phrynosomatidae) in Central Mexico.” Evolution, vol. 49, no. 1, Wiley-Blackwell, 1995, pp. 9–36, doi:10.1111/j.1558-5646.1995.tb05955.x. short: J. Sites, N.H. Barton, K. Reed, Evolution 49 (1995) 9–36. date_created: 2018-12-11T12:08:06Z date_published: 1995-02-01T00:00:00Z date_updated: 2022-06-13T09:24:40Z day: '01' doi: 10.1111/j.1558-5646.1995.tb05955.x extern: '1' external_id: pmid: - '28593667' intvolume: ' 49' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1995.tb05955.x month: '02' oa: 1 oa_version: Published Version page: 9 - 36 pmid: 1 publication: Evolution publication_identifier: issn: - 0014-3820 publication_status: published publisher: Wiley-Blackwell publist_id: '1779' quality_controlled: '1' scopus_import: '1' status: public title: The genetic structure of a mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '1995' ... --- _id: '4296' abstract: - lang: eng text: Three replicate lines of Drosophila melanogaster were cultured at each of two temperatures (16.5⚬C and 25⚬C) in population cages for 4 yr. The lifespans of both sexes and the fecundity and fertility of the females were then measured at both experimental temperatures. The characters showed evidence of adaptation; flies of both sexes from each selection regime showed higher longevity, and females showed higher fecundity and fertility, than flies from the other selection regime when they were tested at the experimental temperature at which they had evolved. Calculation of intrinsic rates of increase under different assumptions about the rate of population increase showed that the difference between the lines from the two selection regimes became less the higher the rate of population increase, because the lines were more similar in early adulthood than they were later. Despite the increased adaptation of the low-temperature lines to the low temperature, like the high temperature lines they produced progeny at a higher rate at the higher temperature. The lines may have independently evolved adaptations to their respective thermal regimes during the experiment, or there may have been a trade-off between adaptation to the two temperatures, or mutation pressure may have lowered adaptation to the temperature that the flies no longer encountered. acknowledgement: We thank Natural Environment Research Council and the Royal Society for financial support. article_processing_charge: No article_type: original author: - first_name: Linda full_name: Partridge, Linda last_name: Partridge - first_name: Brian full_name: Barrie, Brian last_name: Barrie - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Kevin full_name: Fowler, Kevin last_name: Fowler - first_name: Vernon full_name: French, Vernon last_name: French citation: ama: Partridge L, Barrie B, Barton NH, Fowler K, French V. Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature. Evolution. 1995;49(3):538-544. doi:10.1111/j.1558-5646.1995.tb02285.x apa: Partridge, L., Barrie, B., Barton, N. H., Fowler, K., & French, V. (1995). Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1995.tb02285.x chicago: Partridge, Linda, Brian Barrie, Nicholas H Barton, Kevin Fowler, and Vernon French. “Rapid Laboratory Evolution of Adult Life History Traits in Drosophila Melanogaster in Response to Temperature.” Evolution. Wiley-Blackwell, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb02285.x. ieee: L. Partridge, B. Barrie, N. H. Barton, K. Fowler, and V. French, “Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature,” Evolution, vol. 49, no. 3. Wiley-Blackwell, pp. 538–544, 1995. ista: Partridge L, Barrie B, Barton NH, Fowler K, French V. 1995. Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature. Evolution. 49(3), 538–544. mla: Partridge, Linda, et al. “Rapid Laboratory Evolution of Adult Life History Traits in Drosophila Melanogaster in Response to Temperature.” Evolution, vol. 49, no. 3, Wiley-Blackwell, 1995, pp. 538–44, doi:10.1111/j.1558-5646.1995.tb02285.x. short: L. Partridge, B. Barrie, N.H. Barton, K. Fowler, V. French, Evolution 49 (1995) 538–544. date_created: 2018-12-11T12:08:06Z date_published: 1995-06-01T00:00:00Z date_updated: 2022-06-13T08:42:11Z day: '01' doi: 10.1111/j.1558-5646.1995.tb02285.x extern: '1' external_id: pmid: - '28565092 ' intvolume: ' 49' issue: '3' language: - iso: eng main_file_link: - open_access: '1' url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1995.tb02285.x month: '06' oa: 1 oa_version: Published Version page: 538 - 544 pmid: 1 publication: Evolution publication_identifier: issn: - 0014-3820 publication_status: published publisher: Wiley-Blackwell publist_id: '1778' quality_controlled: '1' scopus_import: '1' status: public title: Rapid laboratory evolution of adult life history traits in Drosophila melanogaster in response to temperature type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '1995' ... --- _id: '4298' article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Barton NH. Appendix to “A simulation study of multilocus clines” by S J E Baird. Evolution. 1995;49(6):1038-1045. doi:10.1111/j.1558-5646.1995.tb04431.x apa: Barton, N. H. (1995). Appendix to “A simulation study of multilocus clines” by S J E Baird. Evolution. Wiley. https://doi.org/10.1111/j.1558-5646.1995.tb04431.x chicago: Barton, Nicholas H. “Appendix to ‘A Simulation Study of Multilocus Clines’ by S J E Baird.” Evolution. Wiley, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb04431.x. ieee: N. H. Barton, “Appendix to ‘A simulation study of multilocus clines’ by S J E Baird,” Evolution, vol. 49, no. 6. Wiley, pp. 1038–1045, 1995. ista: Barton NH. 1995. Appendix to ‘A simulation study of multilocus clines’ by S J E Baird. Evolution. 49(6), 1038–1045. mla: Barton, Nicholas H. “Appendix to ‘A Simulation Study of Multilocus Clines’ by S J E Baird.” Evolution, vol. 49, no. 6, Wiley, 1995, pp. 1038–45, doi:10.1111/j.1558-5646.1995.tb04431.x. short: N.H. Barton, Evolution 49 (1995) 1038–1045. date_created: 2018-12-11T12:08:07Z date_published: 1995-12-01T00:00:00Z date_updated: 2022-06-28T07:47:30Z day: '01' doi: 10.1111/j.1558-5646.1995.tb04431.x extern: '1' intvolume: ' 49' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1111/j.1558-5646.1995.tb04431.x month: '12' oa: 1 oa_version: Published Version page: 1038 - 1045 publication: Evolution publication_identifier: issn: - 1558-5646 publication_status: published publisher: Wiley publist_id: '1773' quality_controlled: '1' status: public title: Appendix to "A simulation study of multilocus clines" by S J E Baird type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 49 year: '1995' ... --- _id: '4428' abstract: - lang: eng text: "Hybrid systems are real-time systems that react to both discrete and continuous activities (such as analog signals, time, temperature, and speed). Typical examples of hybrid systems are embedded systems, timing-based communication protocols, and digital circuits at the transistor level. Due to the rapid development of microprocessor technology, hybrid systems directly control much of what we depend on in our daily lives. Consequently, the formal specification and verification of hybrid systems has become an active area of research. This dissertation presents the first general framework for the formal specification and verification of hybrid systems, as well as the first hybrid-system analysis tool--HyTech. The framework consists of a graphical finite-state-machine-like language for modeling hybrid systems, a temporal logic for modeling the requirements of hybrid systems, and a computer procedure that verifies modeled hybrid systems against modeled requirements. The tool HyTech is the implementation of the framework using C++ and Mathematica.\r\n\r\nMore specifically, our hybrid-system modeling language, Hybrid Automata, is an extension of timed automata with discrete and continuous variables whose dynamics are governed by differential equations. Our requirement modeling language, ICTL, is a branching-time temporal logic, and is an extension of TCTL with stop-watch variables. Our verification procedure is a symbolic model-checking procedure that verifies linear hybrid automata against ICTL formulas. To make HyTech more efficient and effective, we use model-checking strategies and abstract operators that can expedite the verification process. To enable HyTech to verify nonlinear hybrid automata, we introduce two translations from nonlinear hybrid automata to linear hybrid automata. We have applied HyTech to analyze more than 30 hybrid-system benchmarks. In this dissertation, we present the application of HyTech to three nontrivial hybrid systems taken from the literature." article_processing_charge: No author: - first_name: Pei full_name: Ho, Pei last_name: Ho citation: ama: Ho P. Automatic analysis of hybrid systems. 1995:1-188. apa: Ho, P. (1995). Automatic analysis of hybrid systems. Cornell University. chicago: Ho, Pei. “Automatic Analysis of Hybrid Systems.” Cornell University, 1995. ieee: P. Ho, “Automatic analysis of hybrid systems,” Cornell University, 1995. ista: Ho P. 1995. Automatic analysis of hybrid systems. Cornell University. mla: Ho, Pei. Automatic Analysis of Hybrid Systems. Cornell University, 1995, pp. 1–188. short: P. Ho, Automatic Analysis of Hybrid Systems, Cornell University, 1995. date_created: 2018-12-11T12:08:48Z date_published: 1995-08-01T00:00:00Z date_updated: 2022-06-28T07:30:34Z day: '01' degree_awarded: PhD extern: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://hdl.handle.net/1813/7193 month: '08' oa: 1 oa_version: Published Version page: 1 - 188 publication_status: published publisher: Cornell University publist_id: '304' status: public supervisor: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 title: Automatic analysis of hybrid systems type: dissertation user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '1995' ...