---
_id: '3481'
abstract:
- lang: eng
text: 1. The influence of intracellular factors on current rectification of different
subtypes of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors
(AMPARs) was studied in rat brain slices by combining fast application of glutamate
with patch pipette perfusion. 2. The peak current-voltage (I-V) relation of the
AMPARs expressed in Bergmann glial cells of cerebellum and dentate gyrus (DG)
basket cells of hippocampus was weakly rectifying in outside-out patches and nystatin-perforated
vesicles, but showed a doubly rectifying shape with a region of reduced slope
between 0 and +40 mV in nucleated patches. The I-V relation of AMPARs expressed
in hippocampal CA3 pyramidal neurones was linear in all recording configurations.
3. Intracellular application of 2.5 μM spermine, a naturally occurring polyamine,
blocked outward currents in outside-oat patches from Bergmann glial cells and
DG basket cells in a voltage-dependent manner, generating I-V relations with a
doubly rectifying shape which were similar to those recorded in nucleated patches.
AMPARs in CA3 pyramidal cell patches were unaffected by 25 μM spermine. 4. The
half-maximal blocking concentration of spermine at +40 mV was 0.3 μM in Bergmann
glial cell patches and 1.5 μM in DG basket cell patches, whereas it was much higher
(≥ 100 μM) for CA3 pyramidal. cell patches. Spermidine also affected current rectification,
but with lower affinity. The block of outward current by polyamines following
voltage jumps developed within < 0.5 ms. 5. We conclude that current rectification,
rather than being an intrinsic property of the Ca2+ permeable AMPAR channel, is
generated by polyamine block.
acknowledgement: We thank Dr B.Sakmann, Dr V.Witzemann, J.Geiger, and A.Roth for helpful
discussions and Dr D.Feldmeyer and Dr A.Villarroel for reading the manuscript. We
also thank M.Kaiser for technical and H.Spiegel for secretarial assistance. Supported
by DFG grant SFB-317/B14(P.J.).
article_processing_charge: No
article_type: original
author:
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Koh D, Burnashev N, Jonas PM. Block of native Ca(2+)-permeable AMPA receptors
in rat brain by intracellular polyamines generates double rectification. Journal
of Physiology. 1995;486(Pt 2):305-312. doi:10.1113/jphysiol.1995.sp020813
apa: Koh, D., Burnashev, N., & Jonas, P. M. (1995). Block of native Ca(2+)-permeable
AMPA receptors in rat brain by intracellular polyamines generates double rectification.
Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020813
chicago: Koh, Duk, Nail Burnashev, and Peter M Jonas. “Block of Native Ca(2+)-Permeable
AMPA Receptors in Rat Brain by Intracellular Polyamines Generates Double Rectification.”
Journal of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020813.
ieee: D. Koh, N. Burnashev, and P. M. Jonas, “Block of native Ca(2+)-permeable AMPA
receptors in rat brain by intracellular polyamines generates double rectification,”
Journal of Physiology, vol. 486, no. Pt 2. Wiley-Blackwell, pp. 305–312,
1995.
ista: Koh D, Burnashev N, Jonas PM. 1995. Block of native Ca(2+)-permeable AMPA
receptors in rat brain by intracellular polyamines generates double rectification.
Journal of Physiology. 486(Pt 2), 305–312.
mla: Koh, Duk, et al. “Block of Native Ca(2+)-Permeable AMPA Receptors in Rat Brain
by Intracellular Polyamines Generates Double Rectification.” Journal of Physiology,
vol. 486, no. Pt 2, Wiley-Blackwell, 1995, pp. 305–12, doi:10.1113/jphysiol.1995.sp020813.
short: D. Koh, N. Burnashev, P.M. Jonas, Journal of Physiology 486 (1995) 305–312.
date_created: 2018-12-11T12:03:33Z
date_published: 1995-07-15T00:00:00Z
date_updated: 2022-06-27T14:53:16Z
day: '15'
doi: 10.1113/jphysiol.1995.sp020813
extern: '1'
external_id:
pmid:
- '7473198'
intvolume: ' 486'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156754/
month: '07'
oa: 1
oa_version: Published Version
page: 305 - 312
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2906'
quality_controlled: '1'
status: public
title: Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular
polyamines generates double rectification
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 486
year: '1995'
...
---
_id: '3480'
abstract:
- lang: eng
text: Recording of glutamate-activated currents in membrane patches was combine
with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified
cells of rat brain slices. Analysis of AMPARs in principal neurons end interneurons
of hippocampus and neocortex and in auditory relay neurons and Bergmann glial
cells indicates that the GluR-B subunit in its flip version determines formation
of receptors with relatively slow gating, whereas the GluR-D subunit promotes
assembly of more rapidly gated receptors. The relation between Ca 2+ permeability
of AMPAR channels and the relative GluR-B mRNA abundance is consistent with the
dominance of this subunit in determining the Ca 2+ permeability of native receptors.
The results suggest that differential expression of GluR-B and GluR-D subunit
genes, as well as splicing end editing of their mRNAs, account for the differences
in gating and Ca 2+ permeability of native AMPAR channels.
acknowledgement: "We thank Ulla Amtmann for efficient help with the molecular analysis.
We also thank M. Kaiser for technical assistance, Dr. J. G. G. Borst for advice
concerning preparation of brainstem slices, and Drs. N. Spruston and G. Stuart for
critically reading the manuscript. Funded in part by Bundesministerium für Forschung
und Technologie grant BCT 364 AZ 321/7291 (P. H. S.) and by Deutsche Forschungsgemeinschaftgrant
SFB-3171814(P. J.). J. R. P. G. and T. M. were supported by the graduate program
of Molecular and Cellular Neurobiology of the University of Heidelberg. The costs
of publication of this article were defrayed in part by the payment of page charges.
This article must therefore be hereby\r\nmarked “advertisement” in accordance with
18 USC Section 1734 solely to Indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Thorsten
full_name: Melcher, Thorsten
last_name: Melcher
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
citation:
ama: Geiger J, Melcher T, Koh D, et al. Relative abundance of subunit mRNAs determines
gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons
in rat CNS. Neuron. 1995;15(1):193-204. doi:10.1016/0896-6273(95)90076-4
apa: Geiger, J., Melcher, T., Koh, D., Sakmann, B., Seeburg, P., Jonas, P. M., &
Monyer, H. (1995). Relative abundance of subunit mRNAs determines gating and Ca(2+)
permeability of AMPA receptors in principal neurons and interneurons in rat CNS.
Neuron. Elsevier. https://doi.org/10.1016/0896-6273(95)90076-4
chicago: Geiger, Jörg, Thorsten Melcher, Duk Koh, Bert Sakmann, Peter Seeburg, Peter
M Jonas, and Hannah Monyer. “Relative Abundance of Subunit MRNAs Determines Gating
and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons
in Rat CNS.” Neuron. Elsevier, 1995. https://doi.org/10.1016/0896-6273(95)90076-4.
ieee: J. Geiger et al., “Relative abundance of subunit mRNAs determines gating
and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons
in rat CNS,” Neuron, vol. 15, no. 1. Elsevier, pp. 193–204, 1995.
ista: Geiger J, Melcher T, Koh D, Sakmann B, Seeburg P, Jonas PM, Monyer H. 1995.
Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability
of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 15(1),
193–204.
mla: Geiger, Jörg, et al. “Relative Abundance of Subunit MRNAs Determines Gating
and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons
in Rat CNS.” Neuron, vol. 15, no. 1, Elsevier, 1995, pp. 193–204, doi:10.1016/0896-6273(95)90076-4.
short: J. Geiger, T. Melcher, D. Koh, B. Sakmann, P. Seeburg, P.M. Jonas, H. Monyer,
Neuron 15 (1995) 193–204.
date_created: 2018-12-11T12:03:33Z
date_published: 1995-07-01T00:00:00Z
date_updated: 2022-06-28T07:47:09Z
day: '01'
doi: 10.1016/0896-6273(95)90076-4
extern: '1'
external_id:
pmid:
- '7619522'
intvolume: ' 15'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/0896627395900764?via%3Dihub
month: '07'
oa: 1
oa_version: Published Version
page: 193 - 204
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2907'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability
of AMPA receptors in principal neurons and interneurons in rat CNS
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1995'
...
---
_id: '3597'
article_processing_charge: No
author:
- first_name: Mark
full_name: Kirkpatrick, Mark
last_name: Kirkpatrick
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kirkpatrick M, Barton NH. Déjà vu all over again. Nature. 1995;377:388-389.
doi:10.1038/377388a0
apa: Kirkpatrick, M., & Barton, N. H. (1995). Déjà vu all over again. Nature.
Nature Publishing Group. https://doi.org/10.1038/377388a0
chicago: Kirkpatrick, Mark, and Nicholas H Barton. “Déjà vu All over Again.” Nature.
Nature Publishing Group, 1995. https://doi.org/10.1038/377388a0.
ieee: M. Kirkpatrick and N. H. Barton, “Déjà vu all over again,” Nature,
vol. 377. Nature Publishing Group, pp. 388–389, 1995.
ista: Kirkpatrick M, Barton NH. 1995. Déjà vu all over again. Nature. 377, 388–389.
mla: Kirkpatrick, Mark, and Nicholas H. Barton. “Déjà vu All over Again.” Nature,
vol. 377, Nature Publishing Group, 1995, pp. 388–89, doi:10.1038/377388a0.
short: M. Kirkpatrick, N.H. Barton, Nature 377 (1995) 388–389.
date_created: 2018-12-11T12:04:09Z
date_published: 1995-10-05T00:00:00Z
date_updated: 2022-06-27T13:00:10Z
day: '05'
doi: 10.1038/377388a0
extern: '1'
external_id:
pmid:
- '7566112 '
intvolume: ' 377'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/377388a0
month: '10'
oa_version: None
page: 388 - 389
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '2786'
quality_controlled: '1'
status: public
title: Déjà vu all over again
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 377
year: '1995'
...
---
_id: '3640'
abstract:
- lang: eng
text: 'The probability of fixation of a favorable mutation is reduced if selection
at other loci causes inherited variation in fitness. A general method for calculating
the fixation probability of an allele that can find itself in a variety of genetic
backgrounds is applied to find the effect of substitutions, fluctuating polymorphisms,
and deleterious mutations in a large population. With loose linkage, r, the effects
depend on the additive genetic variance in relative fitness, var(W), and act by
reducing effective population size by (N/Ne) = 1 + var(W)/2r2. However, tightly
linked loci can have a substantial effect not predictable from Ne. Linked deleterious
mutations reduce the fixation probability of weakly favored alleles by exp (-2U/R),
where U is the total mutation rate and R is the map length in Morgans. Substitutions
can cause a greater reduction: an allele with advantage s < scrit = (pi 2/6)
loge (S/s) [var(W)/R] is very unlikely to be fixed. (S is the advantage of the
substitution impeding fixation.) Fluctuating polymorphisms at many (n) linked
loci can also have a substantial effect, reducing fixation probability by exp
[square root of 2Kn var(W)/R] [K = -1/E((u-u)2/uv) depending on the frequencies
(u,v) at the selected polymorphisms]. Hitchhiking due to all three kinds of selection
may substantially impede adaptation that depends on weakly favored alleles.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Linkage and the limits to natural selection. Genetics. 1995;140(2):821-841.
doi:http://www.genetics.org/content/140/2/821.long
apa: Barton, N. H. (1995). Linkage and the limits to natural selection. Genetics.
Genetics Society of America. http://www.genetics.org/content/140/2/821.long
chicago: Barton, Nicholas H. “Linkage and the Limits to Natural Selection.” Genetics.
Genetics Society of America, 1995. http://www.genetics.org/content/140/2/821.long.
ieee: N. H. Barton, “Linkage and the limits to natural selection,” Genetics,
vol. 140, no. 2. Genetics Society of America, pp. 821–841, 1995.
ista: Barton NH. 1995. Linkage and the limits to natural selection. Genetics. 140(2),
821–841.
mla: Barton, Nicholas H. “Linkage and the Limits to Natural Selection.” Genetics,
vol. 140, no. 2, Genetics Society of America, 1995, pp. 821–41, doi:http://www.genetics.org/content/140/2/821.long.
short: N.H. Barton, Genetics 140 (1995) 821–841.
date_created: 2018-12-11T12:04:23Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-06-24T09:59:08Z
day: '01'
doi: http://www.genetics.org/content/140/2/821.long
extern: '1'
external_id:
pmid:
- '7498757'
intvolume: ' 140'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1206655/
month: '06'
oa: 1
oa_version: Published Version
page: 821 - 841
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2743'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Linkage and the limits to natural selection
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 140
year: '1995'
...
---
_id: '4028'
abstract:
- lang: eng
text: Efficient algorithms are described for computing topological, combinatorial,
and metric properties of the union of finitely many spherical balls in R(d) These
algorithms are based on a simplicial complex dual to a decomposition of the union
of balls using Voronoi cells, and on short inclusion-exclusion formulas derived
from this complex. The algorithms are most relevant in R(3) where unions of finitely
many balls are commonly used as models of molecules.
acknowledgement: This work is supported by the National Science Foundation, under
Grant ASC-9200301, and the Alan T. Waterman award, Grant CCR-9118874. Any opinions,
findings, conclusions, or recommendations expressed in this publication are those
of the author and do not necessarily reflect the view of the National Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. The union of balls and its dual shape. Discrete & Computational
Geometry. 1995;13(1):415-440. doi:10.1007/BF02574053
apa: Edelsbrunner, H. (1995). The union of balls and its dual shape. Discrete
& Computational Geometry. Springer. https://doi.org/10.1007/BF02574053
chicago: Edelsbrunner, Herbert. “The Union of Balls and Its Dual Shape.” Discrete
& Computational Geometry. Springer, 1995. https://doi.org/10.1007/BF02574053.
ieee: H. Edelsbrunner, “The union of balls and its dual shape,” Discrete &
Computational Geometry, vol. 13, no. 1. Springer, pp. 415–440, 1995.
ista: Edelsbrunner H. 1995. The union of balls and its dual shape. Discrete &
Computational Geometry. 13(1), 415–440.
mla: Edelsbrunner, Herbert. “The Union of Balls and Its Dual Shape.” Discrete
& Computational Geometry, vol. 13, no. 1, Springer, 1995, pp. 415–40,
doi:10.1007/BF02574053.
short: H. Edelsbrunner, Discrete & Computational Geometry 13 (1995) 415–440.
date_created: 2018-12-11T12:06:31Z
date_published: 1995-12-01T00:00:00Z
date_updated: 2022-06-27T08:14:48Z
day: '01'
doi: 10.1007/BF02574053
extern: '1'
intvolume: ' 13'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://link.springer.com/article/10.1007/BF02574053
month: '12'
oa: 1
oa_version: Published Version
page: 415 - 440
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2095'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The union of balls and its dual shape
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1995'
...
---
_id: '4029'
abstract:
- lang: eng
text: A general and direct method for computing the Betti numbers of a finite simplicial
complex in Bd is given. This method is complete for d less than or equal to 3,
where versions of this method run in time O(n alpha(n)) and O(n), n the number
of simplices. An implementation of the algorithm is applied to alpha shapes, which
is a novel geometric modeling tool.
acknowledgement: This work is supported by the National Science Foundation under grant
ASC-9200301 and the Alan T. Waterman award, grant CCR-9118874. Any opinions, findings,
conclusions, or recommendations expressed in this publication are those of the authors
and do not necessarily reflect the view of the National Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Cecil
full_name: Delfinado, Cecil
last_name: Delfinado
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Delfinado C, Edelsbrunner H. An incremental algorithm for Betti numbers of
simplicial complexes on the 3-sphere. Computer Aided Geometric Design.
1995;12(7):771-784. doi:10.1016/0167-8396(95)00016-Y
apa: Delfinado, C., & Edelsbrunner, H. (1995). An incremental algorithm for
Betti numbers of simplicial complexes on the 3-sphere. Computer Aided Geometric
Design. Elsevier. https://doi.org/10.1016/0167-8396(95)00016-Y
chicago: Delfinado, Cecil, and Herbert Edelsbrunner. “An Incremental Algorithm for
Betti Numbers of Simplicial Complexes on the 3-Sphere.” Computer Aided Geometric
Design. Elsevier, 1995. https://doi.org/10.1016/0167-8396(95)00016-Y.
ieee: C. Delfinado and H. Edelsbrunner, “An incremental algorithm for Betti numbers
of simplicial complexes on the 3-sphere,” Computer Aided Geometric Design,
vol. 12, no. 7. Elsevier, pp. 771–784, 1995.
ista: Delfinado C, Edelsbrunner H. 1995. An incremental algorithm for Betti numbers
of simplicial complexes on the 3-sphere. Computer Aided Geometric Design. 12(7),
771–784.
mla: Delfinado, Cecil, and Herbert Edelsbrunner. “An Incremental Algorithm for Betti
Numbers of Simplicial Complexes on the 3-Sphere.” Computer Aided Geometric
Design, vol. 12, no. 7, Elsevier, 1995, pp. 771–84, doi:10.1016/0167-8396(95)00016-Y.
short: C. Delfinado, H. Edelsbrunner, Computer Aided Geometric Design 12 (1995)
771–784.
date_created: 2018-12-11T12:06:32Z
date_published: 1995-11-01T00:00:00Z
date_updated: 2022-06-24T09:49:32Z
day: '01'
doi: 10.1016/0167-8396(95)00016-Y
extern: '1'
intvolume: ' 12'
issue: '7'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/016783969500016Y?via%3Dihub
month: '11'
oa_version: None
page: 771 - 784
publication: Computer Aided Geometric Design
publication_identifier:
issn:
- 0167-8396
publication_status: published
publisher: Elsevier
publist_id: '2096'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An incremental algorithm for Betti numbers of simplicial complexes on the 3-sphere
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '1995'
...
---
_id: '4297'
abstract:
- lang: eng
text: The F5 (2n = 34) and FM2 (2n = 44-46) chromosome races of the Sceloporus grammicus
complex form a parapatric hybrid zone in the Mexican state of Hidalgo, characterized
by steep concordant clines among three diagnostic chromosome markers across a
straight-line distance of about 2 km. Here, we show that this zone is actually
structured into local patches in which hybridization extends over an extremely
irregular front. The distribution of hybrid-index (HI) scores across the transect
reveals some hybridization at almost all localities mapped in a central 7 km x
3 km area. Pooling the central samples produces both a strong heterozygote deficit
for all diagnostic markers and strong linkage disequilibria between all pairwise
combinations of these (unlinked) markers. Moreover, a highly significant association
exists between the habitat on which each individual was caught and its karyotype
(F5 chromosomes are more likely to be found on oak). Analysis of genotype frequencies
over a range of spatial scales shows that there is no significant heterozygote
deficit or habitat association within local areas of less than about 200 m; however,
there is significant linkage disequilibrium over the smallest scales (R = D (pquv)1/2
= 0.29, support limits, 0.18-0.36) over 100 m. These patterns suggest that lizards
mate and choose habitats randomly within local patches. This conclusion is supported
by mark-recapture estimates of dispersal (≈ 80 m in a generation) and by inference
of matings from embryo and maternal karyotypes. Closer examination of the two-dimensional
pattern reveals a convoluted cline for all three markers, with a width of 830
m (support limits 770 m-930 m). This cline width, combined with the strength of
local linkage disequilibrium, implies a dispersal rate of σ = 160 m in a generation
and an effective selection pressure of 30% on each chromosome marker. The proportion
of inviable embryos is greater in females from the center of the hybrid zone;
this is caused by effects associated with both karyotype and location. The hybrid
zone is likely to be maintained by selection against chromosomal heterozygotes,
by other kinds of selection against hybrids, and by selection adapting the chromosome
races to different habitats. The structure of the contact may be caused by both
random drift and by selection in relation to habitat.
acknowledgement: For field assistance in collecting and mapping of the zone, we thank
E. Arevalo, I. Goyenechea, D. Hutchison, M. Man- cilia, F. Mendoza, D. Mink, and
J. and H. Sites. The mark- recapture work was carried out by M. Mancilla,
F Mendoza, and A. Gonzales. J.W.S. also thanks T. Hinckley and D. Stevens of the Brigham Young University Department of
Geography for lessons in surveying and map making and use of the field equipment and planimeter. B. Nürnberger provided
the digitized coordinates for individual lizards and assisted with the analysis of
spatial structure and viability. B. Nürnberger, C. MacCallum, J. Mallet, and
J. Searle also provided helpful comments on the manuscript. This work was
supported by National Science Foundation grants BSR 85- 09092 and 88-22751 to
J.W.S., and grants from the Science and Engineering Research Council (GR/H09929)
and Natural Environment Research Council (GR3/8002) and the DarwinTrust to N.H.B.
The Mexican agency Secretaria de DesarrolloUrbano y Ecologia (now Secretaria de Desarrollo Social)
kindly provided scientific collecting permits (to E. Arévalo) for field work in 1989 and 1991.
article_processing_charge: No
article_type: original
author:
- first_name: Jack
full_name: Sites, Jack
last_name: Sites
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Kent
full_name: Reed, Kent
last_name: Reed
citation:
ama: Sites J, Barton NH, Reed K. The genetic structure of a mosaic hybrid zone between
two chromosome races of the Sceloporus grammicus complex (Sauria, Phrynosomatidae)
in central Mexico. Evolution. 1995;49(1):9-36. doi:10.1111/j.1558-5646.1995.tb05955.x
apa: Sites, J., Barton, N. H., & Reed, K. (1995). The genetic structure of a
mosaic hybrid zone between two chromosome races of the Sceloporus grammicus complex
(Sauria, Phrynosomatidae) in central Mexico. Evolution. Wiley-Blackwell.
https://doi.org/10.1111/j.1558-5646.1995.tb05955.x
chicago: Sites, Jack, Nicholas H Barton, and Kent Reed. “The Genetic Structure of
a Mosaic Hybrid Zone between Two Chromosome Races of the Sceloporus Grammicus
Complex (Sauria, Phrynosomatidae) in Central Mexico.” Evolution. Wiley-Blackwell,
1995. https://doi.org/10.1111/j.1558-5646.1995.tb05955.x.
ieee: J. Sites, N. H. Barton, and K. Reed, “The genetic structure of a mosaic hybrid
zone between two chromosome races of the Sceloporus grammicus complex (Sauria,
Phrynosomatidae) in central Mexico,” Evolution, vol. 49, no. 1. Wiley-Blackwell,
pp. 9–36, 1995.
ista: Sites J, Barton NH, Reed K. 1995. The genetic structure of a mosaic hybrid
zone between two chromosome races of the Sceloporus grammicus complex (Sauria,
Phrynosomatidae) in central Mexico. Evolution. 49(1), 9–36.
mla: Sites, Jack, et al. “The Genetic Structure of a Mosaic Hybrid Zone between
Two Chromosome Races of the Sceloporus Grammicus Complex (Sauria, Phrynosomatidae)
in Central Mexico.” Evolution, vol. 49, no. 1, Wiley-Blackwell, 1995, pp.
9–36, doi:10.1111/j.1558-5646.1995.tb05955.x.
short: J. Sites, N.H. Barton, K. Reed, Evolution 49 (1995) 9–36.
date_created: 2018-12-11T12:08:06Z
date_published: 1995-02-01T00:00:00Z
date_updated: 2022-06-13T09:24:40Z
day: '01'
doi: 10.1111/j.1558-5646.1995.tb05955.x
extern: '1'
external_id:
pmid:
- '28593667'
intvolume: ' 49'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1995.tb05955.x
month: '02'
oa: 1
oa_version: Published Version
page: 9 - 36
pmid: 1
publication: Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1779'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The genetic structure of a mosaic hybrid zone between two chromosome races
of the Sceloporus grammicus complex (Sauria, Phrynosomatidae) in central Mexico
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 49
year: '1995'
...
---
_id: '4296'
abstract:
- lang: eng
text: Three replicate lines of Drosophila melanogaster were cultured at each of
two temperatures (16.5⚬C and 25⚬C) in population cages for 4 yr. The lifespans
of both sexes and the fecundity and fertility of the females were then measured
at both experimental temperatures. The characters showed evidence of adaptation;
flies of both sexes from each selection regime showed higher longevity, and females
showed higher fecundity and fertility, than flies from the other selection regime
when they were tested at the experimental temperature at which they had evolved.
Calculation of intrinsic rates of increase under different assumptions about the
rate of population increase showed that the difference between the lines from
the two selection regimes became less the higher the rate of population increase,
because the lines were more similar in early adulthood than they were later. Despite
the increased adaptation of the low-temperature lines to the low temperature,
like the high temperature lines they produced progeny at a higher rate at the
higher temperature. The lines may have independently evolved adaptations to their
respective thermal regimes during the experiment, or there may have been a trade-off
between adaptation to the two temperatures, or mutation pressure may have lowered
adaptation to the temperature that the flies no longer encountered.
acknowledgement: We thank Natural Environment Research Council and the Royal Society
for financial support.
article_processing_charge: No
article_type: original
author:
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
- first_name: Brian
full_name: Barrie, Brian
last_name: Barrie
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Kevin
full_name: Fowler, Kevin
last_name: Fowler
- first_name: Vernon
full_name: French, Vernon
last_name: French
citation:
ama: Partridge L, Barrie B, Barton NH, Fowler K, French V. Rapid laboratory evolution
of adult life history traits in Drosophila melanogaster in response to temperature.
Evolution. 1995;49(3):538-544. doi:10.1111/j.1558-5646.1995.tb02285.x
apa: Partridge, L., Barrie, B., Barton, N. H., Fowler, K., & French, V. (1995).
Rapid laboratory evolution of adult life history traits in Drosophila melanogaster
in response to temperature. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1995.tb02285.x
chicago: Partridge, Linda, Brian Barrie, Nicholas H Barton, Kevin Fowler, and Vernon
French. “Rapid Laboratory Evolution of Adult Life History Traits in Drosophila
Melanogaster in Response to Temperature.” Evolution. Wiley-Blackwell, 1995.
https://doi.org/10.1111/j.1558-5646.1995.tb02285.x.
ieee: L. Partridge, B. Barrie, N. H. Barton, K. Fowler, and V. French, “Rapid laboratory
evolution of adult life history traits in Drosophila melanogaster in response
to temperature,” Evolution, vol. 49, no. 3. Wiley-Blackwell, pp. 538–544,
1995.
ista: Partridge L, Barrie B, Barton NH, Fowler K, French V. 1995. Rapid laboratory
evolution of adult life history traits in Drosophila melanogaster in response
to temperature. Evolution. 49(3), 538–544.
mla: Partridge, Linda, et al. “Rapid Laboratory Evolution of Adult Life History
Traits in Drosophila Melanogaster in Response to Temperature.” Evolution,
vol. 49, no. 3, Wiley-Blackwell, 1995, pp. 538–44, doi:10.1111/j.1558-5646.1995.tb02285.x.
short: L. Partridge, B. Barrie, N.H. Barton, K. Fowler, V. French, Evolution 49
(1995) 538–544.
date_created: 2018-12-11T12:08:06Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-06-13T08:42:11Z
day: '01'
doi: 10.1111/j.1558-5646.1995.tb02285.x
extern: '1'
external_id:
pmid:
- '28565092 '
intvolume: ' 49'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1995.tb02285.x
month: '06'
oa: 1
oa_version: Published Version
page: 538 - 544
pmid: 1
publication: Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1778'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rapid laboratory evolution of adult life history traits in Drosophila melanogaster
in response to temperature
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 49
year: '1995'
...
---
_id: '4298'
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Appendix to “A simulation study of multilocus clines” by S J E Baird.
Evolution. 1995;49(6):1038-1045. doi:10.1111/j.1558-5646.1995.tb04431.x
apa: Barton, N. H. (1995). Appendix to “A simulation study of multilocus clines”
by S J E Baird. Evolution. Wiley. https://doi.org/10.1111/j.1558-5646.1995.tb04431.x
chicago: Barton, Nicholas H. “Appendix to ‘A Simulation Study of Multilocus Clines’
by S J E Baird.” Evolution. Wiley, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb04431.x.
ieee: N. H. Barton, “Appendix to ‘A simulation study of multilocus clines’ by S
J E Baird,” Evolution, vol. 49, no. 6. Wiley, pp. 1038–1045, 1995.
ista: Barton NH. 1995. Appendix to ‘A simulation study of multilocus clines’ by
S J E Baird. Evolution. 49(6), 1038–1045.
mla: Barton, Nicholas H. “Appendix to ‘A Simulation Study of Multilocus Clines’
by S J E Baird.” Evolution, vol. 49, no. 6, Wiley, 1995, pp. 1038–45, doi:10.1111/j.1558-5646.1995.tb04431.x.
short: N.H. Barton, Evolution 49 (1995) 1038–1045.
date_created: 2018-12-11T12:08:07Z
date_published: 1995-12-01T00:00:00Z
date_updated: 2022-06-28T07:47:30Z
day: '01'
doi: 10.1111/j.1558-5646.1995.tb04431.x
extern: '1'
intvolume: ' 49'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/j.1558-5646.1995.tb04431.x
month: '12'
oa: 1
oa_version: Published Version
page: 1038 - 1045
publication: Evolution
publication_identifier:
issn:
- 1558-5646
publication_status: published
publisher: Wiley
publist_id: '1773'
quality_controlled: '1'
status: public
title: Appendix to "A simulation study of multilocus clines" by S J E Baird
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 49
year: '1995'
...
---
_id: '4428'
abstract:
- lang: eng
text: "Hybrid systems are real-time systems that react to both discrete and continuous
activities (such as analog signals, time, temperature, and speed). Typical examples
of hybrid systems are embedded systems, timing-based communication protocols,
and digital circuits at the transistor level. Due to the rapid development of
microprocessor technology, hybrid systems directly control much of what we depend
on in our daily lives. Consequently, the formal specification and verification
of hybrid systems has become an active area of research. This dissertation presents
the first general framework for the formal specification and verification of hybrid
systems, as well as the first hybrid-system analysis tool--HyTech. The framework
consists of a graphical finite-state-machine-like language for modeling hybrid
systems, a temporal logic for modeling the requirements of hybrid systems, and
a computer procedure that verifies modeled hybrid systems against modeled requirements.
The tool HyTech is the implementation of the framework using C++ and Mathematica.\r\n\r\nMore
specifically, our hybrid-system modeling language, Hybrid Automata, is an extension
of timed automata with discrete and continuous variables whose dynamics are governed
by differential equations. Our requirement modeling language, ICTL, is a branching-time
temporal logic, and is an extension of TCTL with stop-watch variables. Our verification
procedure is a symbolic model-checking procedure that verifies linear hybrid automata
against ICTL formulas. To make HyTech more efficient and effective, we use model-checking
strategies and abstract operators that can expedite the verification process.
To enable HyTech to verify nonlinear hybrid automata, we introduce two translations
from nonlinear hybrid automata to linear hybrid automata. We have applied HyTech
to analyze more than 30 hybrid-system benchmarks. In this dissertation, we present
the application of HyTech to three nontrivial hybrid systems taken from the literature."
article_processing_charge: No
author:
- first_name: Pei
full_name: Ho, Pei
last_name: Ho
citation:
ama: Ho P. Automatic analysis of hybrid systems. 1995:1-188.
apa: Ho, P. (1995). Automatic analysis of hybrid systems. Cornell University.
chicago: Ho, Pei. “Automatic Analysis of Hybrid Systems.” Cornell University, 1995.
ieee: P. Ho, “Automatic analysis of hybrid systems,” Cornell University, 1995.
ista: Ho P. 1995. Automatic analysis of hybrid systems. Cornell University.
mla: Ho, Pei. Automatic Analysis of Hybrid Systems. Cornell University, 1995,
pp. 1–188.
short: P. Ho, Automatic Analysis of Hybrid Systems, Cornell University, 1995.
date_created: 2018-12-11T12:08:48Z
date_published: 1995-08-01T00:00:00Z
date_updated: 2022-06-28T07:30:34Z
day: '01'
degree_awarded: PhD
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://hdl.handle.net/1813/7193
month: '08'
oa: 1
oa_version: Published Version
page: 1 - 188
publication_status: published
publisher: Cornell University
publist_id: '304'
status: public
supervisor:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
title: Automatic analysis of hybrid systems
type: dissertation
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...