---
_id: '1945'
abstract:
- lang: eng
text: The effects of ultra-low (10(-18)-10(-14) M) doses (ULD) of biologically active
substances have been reviewed in terms of common regularities of ULD effects and
peculiarities of action of various groups of compounds. The most common and at
the same time paradoxical regularities of ULD action are bi- or polymodal patterns
of dose dependence, absence or presence of an inverse effect at higher doses,
and instability of ULD effect. Possible mechanisms of ULD action including the
mechanism based on the adaptation theory are discussed.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Sergei
full_name: Zaǐtsev, Sergei
last_name: Zaǐtsev
citation:
ama: 'Sazanov LA, Zaǐtsev S. Effect of superlow doses (10(-18)-10-(-14) M) of biologically
active substances: general rules, features, and possible mechanisms. Biochemistry
(Moscow). 1992;57(10):1443-1460.'
apa: 'Sazanov, L. A., & Zaǐtsev, S. (1992). Effect of superlow doses (10(-18)-10-(-14)
M) of biologically active substances: general rules, features, and possible mechanisms.
Biochemistry (Moscow). Izdatel’stvo Nauka.'
chicago: 'Sazanov, Leonid A, and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14)
M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.”
Biochemistry (Moscow). Izdatel’stvo Nauka, 1992.'
ieee: 'L. A. Sazanov and S. Zaǐtsev, “Effect of superlow doses (10(-18)-10-(-14)
M) of biologically active substances: general rules, features, and possible mechanisms,”
Biochemistry (Moscow), vol. 57, no. 10. Izdatel’stvo Nauka, pp. 1443–1460,
1992.'
ista: 'Sazanov LA, Zaǐtsev S. 1992. Effect of superlow doses (10(-18)-10-(-14) M)
of biologically active substances: general rules, features, and possible mechanisms.
Biochemistry (Moscow). 57(10), 1443–1460.'
mla: 'Sazanov, Leonid A., and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14)
M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.”
Biochemistry (Moscow), vol. 57, no. 10, Izdatel’stvo Nauka, 1992, pp. 1443–60.'
short: L.A. Sazanov, S. Zaǐtsev, Biochemistry (Moscow) 57 (1992) 1443–1460.
date_created: 2018-12-11T11:54:51Z
date_published: 1992-10-10T00:00:00Z
date_updated: 2022-03-21T10:47:19Z
day: '10'
extern: '1'
external_id:
pmid:
- '1457592 '
intvolume: ' 57'
issue: '10'
language:
- iso: eng
main_file_link:
- url: https://europepmc.org/article/med/1457592
month: '10'
oa_version: None
page: 1443 - 1460
pmid: 1
publication: Biochemistry (Moscow)
publication_identifier:
issn:
- 0006-2979
publication_status: published
publisher: Izdatel'stvo Nauka
publist_id: '5138'
quality_controlled: '1'
status: public
title: 'Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances:
general rules, features, and possible mechanisms'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 57
year: '1992'
...
---
_id: '2486'
abstract:
- lang: eng
text: Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1), which
is linked to phosphoinositide (PI) hydrolysis, was investigated in adult and developing
rat central nervous system (CNS) by in situ hybridization. Transcripts of mGluR1
were specifically localized to neurons and widely distributed throughout the adult
rat brain. Most intensely labeled neurons were Purkinje cells of the cerebellum,
mitral and tufted cells of the olfactory bulb, and neurons in the hippocampus,
lateral septum, thalamus, globus pallidus, entopeduncular nucleus, ventral pallidum,
magnocellular preoptic nucleus, substantia nigra, and dorsal cochlear nucleus.
Moderately labeled neurons were seen in high density in the dentate gyrus, striatum,
islands of Calleja, superficial layers of the retrosplenial, cingulate and entorhinal
cortices, mammillary nuclei, red nucleus, and superior colliculus. In the developing
rat brain, the level of mGluR1 expression gradually increased during early postnatal
days in accordance with the maturation of neuronal elements. These results show
prominent expression of mGluR1 in the major targets of putative glutamatergic
pathways and unique distribution pattern of mGluR1 distinct from those reported
for ionotropic subtypes of glutamate receptors, suggesting specific roles of mGluR1
in the glutamatergic system.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help. This
work was supported in part by research grants from Senri Life Science Foundation
and the Ministry of Education, Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Shigemoto R, Nakanishi S, Mizuno N. Distribution of the mRNA for a metabotropic
glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization
study in adult and developing rat. Journal of Comparative Neurology. 1992;322(1):121-135.
doi:10.1002/cne.903220110'
apa: 'Shigemoto, R., Nakanishi, S., & Mizuno, N. (1992). Distribution of the
mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system:
An in situ hybridization study in adult and developing rat. Journal of Comparative
Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.903220110'
chicago: 'Shigemoto, Ryuichi, Shigetada Nakanishi, and Noboru Mizuno. “Distribution
of the MRNA for a Metabotropic Glutamate Receptor (MGluR1) in the Central Nervous
System: An in Situ Hybridization Study in Adult and Developing Rat.” Journal
of Comparative Neurology. Wiley-Blackwell, 1992. https://doi.org/10.1002/cne.903220110.'
ieee: 'R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distribution of the mRNA for
a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in
situ hybridization study in adult and developing rat,” Journal of Comparative
Neurology, vol. 322, no. 1. Wiley-Blackwell, pp. 121–135, 1992.'
ista: 'Shigemoto R, Nakanishi S, Mizuno N. 1992. Distribution of the mRNA for a
metabotropic glutamate receptor (mGluR1) in the central nervous system: An in
situ hybridization study in adult and developing rat. Journal of Comparative Neurology.
322(1), 121–135.'
mla: 'Shigemoto, Ryuichi, et al. “Distribution of the MRNA for a Metabotropic Glutamate
Receptor (MGluR1) in the Central Nervous System: An in Situ Hybridization Study
in Adult and Developing Rat.” Journal of Comparative Neurology, vol. 322,
no. 1, Wiley-Blackwell, 1992, pp. 121–35, doi:10.1002/cne.903220110.'
short: R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 322
(1992) 121–135.
date_created: 2018-12-11T11:57:57Z
date_published: 1992-08-01T00:00:00Z
date_updated: 2022-03-21T09:41:37Z
day: '01'
doi: 10.1002/cne.903220110
extern: '1'
external_id:
pmid:
- '1430307'
intvolume: ' 322'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/cne.903220110
month: '08'
oa_version: Published Version
page: 121 - 135
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4415'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in
the central nervous system: An in situ hybridization study in adult and developing
rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 322
year: '1992'
...
---
_id: '2485'
abstract:
- lang: eng
text: Endothelins (ETs) are very potent vasoconstrictive peptides and have diverse
functions in both vascular and nonvascular tissues. This investigation concerns
the tissue distribution and cellular localization of rat mRNAs encoding two different
subtypes of ET receptors (ET(A) and ET(B)). We isolated 46 cDNA clones from a
rat lung cDNA library by hybridization with the bovine ET(A) cDNA. The characterization
of these cDNA clones indicated that they represent either the ET(A) or ET(B) cDNA.
In situ and blot hybridization analyses revealed that the rat ET(A) mRNA is predominantly
expressed in vascular smooth muscle cells of a variety of tissues, bronchial smooth
muscle cells, myocardium, and the pituitary gland. There is no significant expression
of ET(B) mRNA in vascular smooth muscle cells, and ET(A), thus, plays a primary
role in ET-induced vascular contraction. ET(B) mRNA is more widely distributed
in various cell types of many tissues. Its prominent expression is seen in glial
cells throughout the brain regions, epithelial cells of the choroid plexus, ependymal
cells lining the ventricle, myocardium, endothelial cells of glomeruli, and epithelial
cells of the thin segments of Henle's loops. Our investigation demonstrates that
the mRNAs for the two subtypes of rat ET receptors show specialized expression
patterns of cell types in both brain and peripheral tissues.
article_processing_charge: No
article_type: original
author:
- first_name: Seiji
full_name: Hori, Seiji
last_name: Hori
- first_name: Yasato
full_name: Komatsu, Yasato
last_name: Komatsu
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. Distinct tissue distribution
and cellular localization of two messenger ribonucleic acids encoding different
subtypes of rat endothelin receptors. Endocrinology. 1992;130(4):1885-1895.
doi:10.1210/endo.130.4.1312429
apa: Hori, S., Komatsu, Y., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1992).
Distinct tissue distribution and cellular localization of two messenger ribonucleic
acids encoding different subtypes of rat endothelin receptors. Endocrinology.
The Endocrine Society. https://doi.org/10.1210/endo.130.4.1312429
chicago: Hori, Seiji, Yasato Komatsu, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada
Nakanishi. “Distinct Tissue Distribution and Cellular Localization of Two Messenger
Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors.” Endocrinology.
The Endocrine Society, 1992. https://doi.org/10.1210/endo.130.4.1312429.
ieee: S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Distinct
tissue distribution and cellular localization of two messenger ribonucleic acids
encoding different subtypes of rat endothelin receptors,” Endocrinology,
vol. 130, no. 4. The Endocrine Society, pp. 1885–1895, 1992.
ista: Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. 1992. Distinct tissue
distribution and cellular localization of two messenger ribonucleic acids encoding
different subtypes of rat endothelin receptors. Endocrinology. 130(4), 1885–1895.
mla: Hori, Seiji, et al. “Distinct Tissue Distribution and Cellular Localization
of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin
Receptors.” Endocrinology, vol. 130, no. 4, The Endocrine Society, 1992,
pp. 1885–95, doi:10.1210/endo.130.4.1312429.
short: S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, S. Nakanishi, Endocrinology
130 (1992) 1885–1895.
date_created: 2018-12-11T11:57:56Z
date_published: 1992-04-01T00:00:00Z
date_updated: 2022-03-21T09:54:59Z
day: '01'
doi: 10.1210/endo.130.4.1312429
extern: '1'
external_id:
pmid:
- '1312429'
intvolume: ' 130'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://academic.oup.com/endo/article-abstract/130/4/1885/2535978
month: '04'
oa_version: None
page: 1885 - 1895
pmid: 1
publication: Endocrinology
publication_identifier:
issn:
- 0013-7227
publication_status: published
publisher: The Endocrine Society
publist_id: '4416'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct tissue distribution and cellular localization of two messenger ribonucleic
acids encoding different subtypes of rat endothelin receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 130
year: '1992'
...
---
_id: '2484'
abstract:
- lang: eng
text: Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain
cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate
receptor (mGluR1). The cloned receptors show considerable sequence similarity
with mGluR1 and possess a large extracellular domain preceding the seven putative
membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells
different from those expressing mGluR1 and mediates an efficient inhibition of
forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus
form a novel family of G protein-coupled receptors that differ in their signal
transduction and expression patterns.
acknowledgement: 'We are grateful to Noboru Mizuno for helpful discussion and Akira
Uesugi for photographic assistance. This work was sup. ported in part by research
grants from the Ministry of Education, Science and Culture of Japan. The costs of
publication of this article were defrayed in part by the payment of page charges.
This article must therefore be hereby marked "advertisement" in accordance with
18 USC Sec-tion 1734 solely to indicate this fact. '
article_processing_charge: No
article_type: original
author:
- first_name: Yasuto
full_name: Tanabe, Yasuto
last_name: Tanabe
- first_name: Masayuki
full_name: Masu, Masayuki
last_name: Masu
- first_name: Takahiro
full_name: Ishii, Takahiro
last_name: Ishii
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A family of metabotropic
glutamate receptors. Neuron. 1992;8(1):169-179. doi:10.1016/0896-6273(92)90118-W
apa: Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992).
A family of metabotropic glutamate receptors. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90118-W
chicago: Tanabe, Yasuto, Masayuki Masu, Takahiro Ishii, Ryuichi Shigemoto, and Shigetada
Nakanishi. “A Family of Metabotropic Glutamate Receptors.” Neuron. Elsevier,
1992. https://doi.org/10.1016/0896-6273(92)90118-W.
ieee: Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, and S. Nakanishi, “A family of
metabotropic glutamate receptors,” Neuron, vol. 8, no. 1. Elsevier, pp.
169–179, 1992.
ista: Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic
glutamate receptors. Neuron. 8(1), 169–179.
mla: Tanabe, Yasuto, et al. “A Family of Metabotropic Glutamate Receptors.” Neuron,
vol. 8, no. 1, Elsevier, 1992, pp. 169–79, doi:10.1016/0896-6273(92)90118-W.
short: Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, S. Nakanishi, Neuron 8 (1992)
169–179.
date_created: 2018-12-11T11:57:56Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-21T10:17:07Z
day: '01'
doi: 10.1016/0896-6273(92)90118-W
extern: '1'
external_id:
pmid:
- '1309649 '
intvolume: ' 8'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/089662739290118W?via%3Dihub
month: '01'
oa_version: None
page: 169 - 179
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4417'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A family of metabotropic glutamate receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 8
year: '1992'
...
---
_id: '2533'
abstract:
- lang: eng
text: A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated
through polymerase chain reaction-mediated DNA amplification by using primer sequences
conserved among the metabotropic glutamate receptor (mGluR) family and by the
subsequent screening of a rat brain cDNA library. The cloned receptor consists
of 1171 amino acid residues and exhibits a structural architecture common to the
mGluR family, possessing a large extracellular domain preceding the seven putative
membrane-spanning segments. mGluR5 shows the highest sequence similarity to mGluR1
among the mGluR members and is coupled to the stimulation of phosphatidylinositol
hydrolysis/ Ca2+ signal transduction in Chinese hamster ovary cells transfected
with the cloned cDNA. This receptor also resembles mGluR1 in its agonist selectivity
and antagonist responses; the potency rank order of agonists for mGluR5 was determined
to be quisqualate > L-glutamate ≥ ibotenate > trans-1-aminocyclopentane-1,3-dicarboxylate.
Blot and in situ hybridization analyses indicated that mGluR5 mRNA is widely distributed
in neuronal cells of the central nervous system and is expressed differently from
mGluR1 mRNA in many brain regions. This investigation thus demonstrates that there
is an additional mGluR subtype which closely resembles mGluR1 in its signal transduction
and pharmacological properties and is expressed in specialized neuronal cells
in the central nervous system.
acknowledgement: We are grateful to Seiji Ito for help of Ca2+ measurements and Akira
Uesugi for photographic assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Hidemitsu
full_name: Sugihara, Hidemitsu
last_name: Sugihara
- first_name: Hiroyuki
full_name: Nawa, Hiroyuki
last_name: Nawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization
of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+
signal transduction. Journal of Biological Chemistry. 1992;267(19):13361-13368.
doi:10.1016/S0021-9258(18)42219-3
apa: Abe, T., Sugihara, H., Nawa, H., Shigemoto, R., Mizuno, N., & Nakanishi,
S. (1992). Molecular characterization of a novel metabotropic glutamate receptor
mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/S0021-9258(18)42219-3
chicago: Abe, Takaaki, Hidemitsu Sugihara, Hiroyuki Nawa, Ryuichi Shigemoto, Noboru
Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a Novel Metabotropic
Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.”
Journal of Biological Chemistry. American Society for Biochemistry and
Molecular Biology, 1992. https://doi.org/10.1016/S0021-9258(18)42219-3.
ieee: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Molecular
characterization of a novel metabotropic glutamate receptor mGluR5 coupled to
inositol phosphate/Ca2+ signal transduction,” Journal of Biological Chemistry,
vol. 267, no. 19. American Society for Biochemistry and Molecular Biology, pp.
13361–13368, 1992.
ista: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1992. Molecular
characterization of a novel metabotropic glutamate receptor mGluR5 coupled to
inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry.
267(19), 13361–13368.
mla: Abe, Takaaki, et al. “Molecular Characterization of a Novel Metabotropic Glutamate
Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” Journal
of Biological Chemistry, vol. 267, no. 19, American Society for Biochemistry
and Molecular Biology, 1992, pp. 13361–68, doi:10.1016/S0021-9258(18)42219-3.
short: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal
of Biological Chemistry 267 (1992) 13361–13368.
date_created: 2018-12-11T11:58:14Z
date_published: 1992-07-05T00:00:00Z
date_updated: 2022-03-17T15:08:29Z
day: '05'
doi: 10.1016/S0021-9258(18)42219-3
extern: '1'
external_id:
pmid:
- '1320017'
intvolume: ' 267'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925818422193
month: '07'
oa: 1
oa_version: Published Version
page: 13361 - 13368
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4366'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5
coupled to inositol phosphate/Ca2+ signal transduction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 267
year: '1992'
...
---
_id: '2535'
abstract:
- lang: eng
text: We report the molecular characterization of two novel rat helix-loop-helix
(HLH) proteins, designated HES-1 and HES-3, that show structural homology to the
Drosophila hairy and Enhancer of split [E(spl)] proteins, both of which are required
for normal neurogenesis. HES-1 mRNA, expressed in various tissues of both embryos
and adults, is present at a high level in the epithelial cells, including the
embryonal neuroepithelial cells, as well as in the mesoderm-derived tissues such
as the embryonal muscle. In contrast, HES-3 mRNA is produced exclusively in cerebellar
Purkinje cells. HES-1 represses transcription by binding to the N box, which is
a recognition sequence of E(spl) proteins. Interestingly, neither HES-1 nor HES-3
alone interacts efficiently with the E box, but each protein decreases the transcription
induced by E-box-binding HLH activators such as E47. Furthermore, HES-1 also inhibits
the functions of MyoD and MASH1 and effectively diminishes the myogenic conversion
of C3H10T1/2 cells induced by MyoD. These results suggest that HES-1 may play
an important role in mammalian development by negatively acting on the two different
sequences while HES-3 acts as a repressor in a specific type of neurons.
acknowledgement: "We thank Professor Noboru Mizuno for his kind help with in situ
hybridization experiments, Akira Uesugi and Dr. Chihiro\r\nAkazawa for photographic
assistance, Drs. Elizabeth Knust and Jose A. Campos-Ortega for communicating their
unpublished results, Dr. Shinji Fushiki for useful discussion, Dr. Mikio Nishizawa
and Professor Shigekazu Nagata for pMNT, Dr. David Baltimore for the E47 expression
vector, Drs. Yoichiro Nabeshima and Atsuko Fujisawa for the MyoD expression vector
and the reporter plasmid with the MCK enhancer, and Dr. Makoto Ishibashi for his
help in isolating the human E47 eDNA clone. This work was supported in part by research
grants from the Ministry of Education, Science, and Culture of Japan. The publication
costs of this article were defrayed in part by payment of page charges. This article
must therefore be hereby marked \"advertisement\" in accordance with 18 USC section
1734 solely to indicate this fact. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Yoshiki
full_name: Sasai, Yoshiki
last_name: Sasai
- first_name: Ryoichiro
full_name: Kageyama, Ryoichiro
last_name: Kageyama
- first_name: Yoshiaki
full_name: Tagawa, Yoshiaki
last_name: Tagawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix
factors structurally related to Drosophila hairy and Enhancer of split. Genes
and Development. 1992;6(12 B):2620-2634. doi:10.1101/gad.6.12b.2620
apa: Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R., & Nakanishi, S. (1992).
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy
and Enhancer of split. Genes and Development. Cold Spring Harbor Laboratory
Press. https://doi.org/10.1101/gad.6.12b.2620
chicago: Sasai, Yoshiki, Ryoichiro Kageyama, Yoshiaki Tagawa, Ryuichi Shigemoto,
and Shigetada Nakanishi. “Two Mammalian Helix-Loop-Helix Factors Structurally
Related to Drosophila Hairy and Enhancer of Split.” Genes and Development.
Cold Spring Harbor Laboratory Press, 1992. https://doi.org/10.1101/gad.6.12b.2620.
ieee: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, and S. Nakanishi, “Two mammalian
helix-loop-helix factors structurally related to Drosophila hairy and Enhancer
of split,” Genes and Development, vol. 6, no. 12 B. Cold Spring Harbor
Laboratory Press, pp. 2620–2634, 1992.
ista: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. 1992. Two mammalian
helix-loop-helix factors structurally related to Drosophila hairy and Enhancer
of split. Genes and Development. 6(12 B), 2620–2634.
mla: Sasai, Yoshiki, et al. “Two Mammalian Helix-Loop-Helix Factors Structurally
Related to Drosophila Hairy and Enhancer of Split.” Genes and Development,
vol. 6, no. 12 B, Cold Spring Harbor Laboratory Press, 1992, pp. 2620–34, doi:10.1101/gad.6.12b.2620.
short: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, S. Nakanishi, Genes and Development
6 (1992) 2620–2634.
date_created: 2018-12-11T11:58:15Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-17T14:52:29Z
day: '01'
doi: 10.1101/gad.6.12b.2620
extern: '1'
external_id:
pmid:
- '1340473'
intvolume: ' 6'
issue: 12 B
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://genesdev.cshlp.org/content/6/12b/2620
month: '01'
oa: 1
oa_version: Published Version
page: 2620 - 2634
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '4364'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Two mammalian helix-loop-helix factors structurally related to Drosophila hairy
and Enhancer of split
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1992'
...
---
_id: '2532'
abstract:
- lang: eng
text: In the present study, we have investigated the expression of both the erythrocyte-type
(GLUT1) and the brain-type (GLUT3) glucose transporter isoforms in primary human
brain tumors. In situ hybridization made it possible to localize and semiquantify
both GLUT1 and GLUT3 mRNAs of individual cells in all 18 samples examined. More
signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocytoma cells,
while the reverse was the case in all 6 meningiomas. In astrocytomas, for both
mRNAs, the density of silver grains over tumor cells was well correlated with
the malignancy of the cells. This correlation was, as was also confirmed by Northern
blot analysis, more marked with GLUT3 mRNA than with GLUT1 mRNA. In 2 of 5 anaplastic
astrocytomas and in all 3 glioblastomas, numerous tumor cells with large amounts
of both mRNAs tended to surround the perivascular regions. 'Tumor vessels' with
endothelial proliferation, an almost pathognomonic feature of glioblastomas, expressed
much GLUT3 mRNA but no significant GLUT1 mRNA, while a single- or a few-layered
capillary endothelium expressed much GLUT1 mRNA. The distribution of both mRNAs
was in good accordance with that of both proteins. Our results suggest that the
expression of both glucose transporter isoforms may contribute to the maintenance
of human brain tumors and that the expression of the GLUT3 isoform may be closely
related to the malignant change of astrocytomas and particularly related to the
aberrant neovascularization which accompanies glioblastomas.
acknowledgement: 'We wish to acknowledge generous donations of human samples by the
following neurosurgeons: Drs. Taro Fukumitsu. Akinori Kondo, Toyoshiro Yamamoto,
Juji Takeuchi, Junya Hanakita, Syunichi Yoneda, and Michio Nishikawa. We are very
grateful to Dr. G. I. Bell (The University of Chicago) for providing the cDNA clones
of GLUTI and GLUT3. We thank Drs. Yoshifumi Yokota, Yuichiro Yamada. and Manabu
Fukumoto for their helpful advice. We also thank Yoshinobu Toda and Hiroko Sato
for their expert technical assistance. Supported in part by Grants in Aids for Basic
Research on Radiation Therapy (03151034) and Special Project Research on Cancer
Bio-Science from the Ministry of Education, Science, and Culture of Japan, by Takeda
Medical Foundation, and by Monbusho International Scientific Research: Joint Research.'
article_processing_charge: No
article_type: original
author:
- first_name: Tatsuya
full_name: Nishioka, Tatsuya
last_name: Nishioka
- first_name: Yoshifumi
full_name: Oda, Yoshifumi
last_name: Oda
- first_name: Yutaka
full_name: Seino, Yutaka
last_name: Seino
- first_name: Taizo
full_name: Yamamoto, Taizo
last_name: Yamamoto
- first_name: Nobuya
full_name: Inagaki, Nobuya
last_name: Inagaki
- first_name: Hideki
full_name: Yano, Hideki
last_name: Yano
- first_name: Hiroo
full_name: Imura, Hiroo
last_name: Imura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Haruhiko
full_name: Kikuchi, Haruhiko
last_name: Kikuchi
citation:
ama: Nishioka T, Oda Y, Seino Y, et al. Distribution of the glucose transporters
in human brain tumors. Cancer Research. 1992;52(14):3972-3979.
apa: Nishioka, T., Oda, Y., Seino, Y., Yamamoto, T., Inagaki, N., Yano, H., … Kikuchi,
H. (1992). Distribution of the glucose transporters in human brain tumors. Cancer
Research. American Association for Cancer Research.
chicago: Nishioka, Tatsuya, Yoshifumi Oda, Yutaka Seino, Taizo Yamamoto, Nobuya
Inagaki, Hideki Yano, Hiroo Imura, Ryuichi Shigemoto, and Haruhiko Kikuchi. “Distribution
of the Glucose Transporters in Human Brain Tumors.” Cancer Research. American
Association for Cancer Research, 1992.
ieee: T. Nishioka et al., “Distribution of the glucose transporters in human
brain tumors,” Cancer Research, vol. 52, no. 14. American Association for
Cancer Research, pp. 3972–3979, 1992.
ista: Nishioka T, Oda Y, Seino Y, Yamamoto T, Inagaki N, Yano H, Imura H, Shigemoto
R, Kikuchi H. 1992. Distribution of the glucose transporters in human brain tumors.
Cancer Research. 52(14), 3972–3979.
mla: Nishioka, Tatsuya, et al. “Distribution of the Glucose Transporters in Human
Brain Tumors.” Cancer Research, vol. 52, no. 14, American Association for
Cancer Research, 1992, pp. 3972–79.
short: T. Nishioka, Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura,
R. Shigemoto, H. Kikuchi, Cancer Research 52 (1992) 3972–3979.
date_created: 2018-12-11T11:58:13Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-17T15:38:42Z
day: '01'
extern: '1'
external_id:
pmid:
- '1617673'
intvolume: ' 52'
issue: '14'
language:
- iso: eng
main_file_link:
- url: https://aacrjournals.org/cancerres/article/52/14/3972/497930/Distribution-of-the-Glucose-Transporters-in-Human
month: '01'
oa_version: None
page: 3972 - 3979
pmid: 1
publication: Cancer Research
publication_identifier:
issn:
- 0008-5472
publication_status: published
publisher: American Association for Cancer Research
publist_id: '4367'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of the glucose transporters in human brain tumors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 52
year: '1992'
...
---
_id: '2534'
abstract:
- lang: eng
text: Vasoactive intestinal polypeptide (VIP), a 28 amino acid peptide hormone,
plays many physiological roles in the peripheral and central nerve systems. A
functional cDNA clone of the VIP receptor was isolated from a rat lung cDNA library
by cross-hybridization with the secretin receptor cDNA. VIP bound the cloned VIP
receptor expressed in mouse COP cells and stimulated adenylate cyclase through
the cloned receptor. The rat VIP receptor consists of 459 amino acids with a calculated
Mr of 52,054 and contains seven transmembrane segments. It is structurally related
to the secretin, calcitonin, and parathyroid hormone receptors, suggesting that
they constitute a new subfamily of the G5 protein - coupled receptors. VIP receptor
mRNA was detected in various rat tissues including liver, lung, intestines, and
brain. In situ hybridization revealed that VIP receptor mRNA is widely distributed
in neuronal cells of the adult rat brain, with a relatively high expression in
the cerebral cortex and hippocampus.
acknowledgement: "We thank Drs. R. Yoshida, K. Katoh, and K. lmamura for help with
the in situ hybridization, Dr. M. Nishizawa for discussion, and Ms. M. lkeda for
secretarial assistance. This work was supported in part by a Grant-in-Aid from the
Ministry of Education, Science and Culture of Japan. The costs of publication of
this article were defrayed in part\r\nby the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 USC Section
1734 solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Takeshi
full_name: Ishihara, Takeshi
last_name: Ishihara
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kensaku
full_name: Mori, Kensaku
last_name: Mori
- first_name: Kenji
full_name: Takahashi, Kenji
last_name: Takahashi
- first_name: Shigekazu
full_name: Nagata, Shigekazu
last_name: Nagata
citation:
ama: Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. Functional expression
and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.
Neuron. 1992;8(4):811-819. doi:10.1016/0896-6273(92)90101-I
apa: Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., & Nagata, S. (1992).
Functional expression and tissue distribution of a novel receptor for vasoactive
intestinal polypeptide. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90101-I
chicago: Ishihara, Takeshi, Ryuichi Shigemoto, Kensaku Mori, Kenji Takahashi, and
Shigekazu Nagata. “Functional Expression and Tissue Distribution of a Novel Receptor
for Vasoactive Intestinal Polypeptide.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90101-I.
ieee: T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, and S. Nagata, “Functional
expression and tissue distribution of a novel receptor for vasoactive intestinal
polypeptide,” Neuron, vol. 8, no. 4. Elsevier, pp. 811–819, 1992.
ista: Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. 1992. Functional expression
and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.
Neuron. 8(4), 811–819.
mla: Ishihara, Takeshi, et al. “Functional Expression and Tissue Distribution of
a Novel Receptor for Vasoactive Intestinal Polypeptide.” Neuron, vol. 8,
no. 4, Elsevier, 1992, pp. 811–19, doi:10.1016/0896-6273(92)90101-I.
short: T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, S. Nagata, Neuron 8 (1992)
811–819.
date_created: 2018-12-11T11:58:14Z
date_published: 1992-04-01T00:00:00Z
date_updated: 2022-03-17T13:33:07Z
day: '01'
doi: 10.1016/0896-6273(92)90101-I
extern: '1'
external_id:
pmid:
- '1314625'
intvolume: ' 8'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/089662739290101I?via%3Dihub
month: '04'
oa_version: None
page: 811 - 819
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4363'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional expression and tissue distribution of a novel receptor for vasoactive
intestinal polypeptide
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 8
year: '1992'
...
---
_id: '2531'
abstract:
- lang: eng
text: The distribution of NMDA receptor (NMDAR1) on neurons in the peripheral ganglia
was examined in the adult rat by in situ hybridization. NMDAR1 mRNA was expressed
in all neurons in the sensory and autonomic ganglia examined; in the dorsal root,
trigeminal, nodose, superior cervical, and sphenopalatine ganglia. Possible roles
of the NMDA receptor on the sensory and autonomic ganglion neurons are discussed.
acknowledgement: The photographic help of Mr. Akira Uesugi is gratefully acknowledged.
This work has been supported by research grants from the Ministry of Education,
Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. Expression of the mRNA for the
rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. Neuroscience
Letters. 1992;144(1-2):229-232. doi:10.1016/0304-3940(92)90756-W
apa: Shigemoto, R., Ohishi, H., Nakanishi, S., & Mizuno, N. (1992). Expression
of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion
neurons. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(92)90756-W
chicago: Shigemoto, Ryuichi, Hitoshi Ohishi, Shigetada Nakanishi, and Noboru Mizuno.
“Expression of the MRNA for the Rat NMDA Receptor (NMDAR1) in the Sensory and
Autonomic Ganglion Neurons.” Neuroscience Letters. Elsevier, 1992. https://doi.org/10.1016/0304-3940(92)90756-W.
ieee: R. Shigemoto, H. Ohishi, S. Nakanishi, and N. Mizuno, “Expression of the mRNA
for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons,”
Neuroscience Letters, vol. 144, no. 1–2. Elsevier, pp. 229–232, 1992.
ista: Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. 1992. Expression of the mRNA
for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons.
Neuroscience Letters. 144(1–2), 229–232.
mla: Shigemoto, Ryuichi, et al. “Expression of the MRNA for the Rat NMDA Receptor
(NMDAR1) in the Sensory and Autonomic Ganglion Neurons.” Neuroscience Letters,
vol. 144, no. 1–2, Elsevier, 1992, pp. 229–32, doi:10.1016/0304-3940(92)90756-W.
short: R. Shigemoto, H. Ohishi, S. Nakanishi, N. Mizuno, Neuroscience Letters 144
(1992) 229–232.
date_created: 2018-12-11T11:58:13Z
date_published: 1992-09-14T00:00:00Z
date_updated: 2022-03-18T13:15:02Z
day: '14'
doi: 10.1016/0304-3940(92)90756-W
extern: '1'
external_id:
pmid:
- '1436707'
intvolume: ' 144'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/030439409290756W
month: '09'
oa_version: None
page: 229 - 232
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4368'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and
autonomic ganglion neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 144
year: '1992'
...
---
_id: '2714'
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. On some problems of P. Turán concerning power sums of complex numbers.
Acta Mathematica Hungarica. 1992;59(1-2):11-24. doi:10.1007/BF00052086
apa: Erdös, L. (1992). On some problems of P. Turán concerning power sums of complex
numbers. Acta Mathematica Hungarica. Springer. https://doi.org/10.1007/BF00052086
chicago: Erdös, László. “On Some Problems of P. Turán Concerning Power Sums of Complex
Numbers.” Acta Mathematica Hungarica. Springer, 1992. https://doi.org/10.1007/BF00052086.
ieee: L. Erdös, “On some problems of P. Turán concerning power sums of complex numbers,”
Acta Mathematica Hungarica, vol. 59, no. 1–2. Springer, pp. 11–24, 1992.
ista: Erdös L. 1992. On some problems of P. Turán concerning power sums of complex
numbers. Acta Mathematica Hungarica. 59(1–2), 11–24.
mla: Erdös, László. “On Some Problems of P. Turán Concerning Power Sums of Complex
Numbers.” Acta Mathematica Hungarica, vol. 59, no. 1–2, Springer, 1992,
pp. 11–24, doi:10.1007/BF00052086.
short: L. Erdös, Acta Mathematica Hungarica 59 (1992) 11–24.
date_created: 2018-12-11T11:59:13Z
date_published: 1992-03-01T00:00:00Z
date_updated: 2022-03-16T15:33:08Z
day: '01'
doi: 10.1007/BF00052086
extern: '1'
intvolume: ' 59'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF00052086
month: '03'
oa_version: None
page: 11 - 24
publication: Acta Mathematica Hungarica
publication_identifier:
issn:
- 0001-5954
publication_status: published
publisher: Springer
publist_id: '4182'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On some problems of P. Turán concerning power sums of complex numbers
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 59
year: '1992'
...