--- _id: '1945' abstract: - lang: eng text: The effects of ultra-low (10(-18)-10(-14) M) doses (ULD) of biologically active substances have been reviewed in terms of common regularities of ULD effects and peculiarities of action of various groups of compounds. The most common and at the same time paradoxical regularities of ULD action are bi- or polymodal patterns of dose dependence, absence or presence of an inverse effect at higher doses, and instability of ULD effect. Possible mechanisms of ULD action including the mechanism based on the adaptation theory are discussed. article_processing_charge: No article_type: original author: - first_name: Leonid A full_name: Sazanov, Leonid A id: 338D39FE-F248-11E8-B48F-1D18A9856A87 last_name: Sazanov orcid: 0000-0002-0977-7989 - first_name: Sergei full_name: Zaǐtsev, Sergei last_name: Zaǐtsev citation: ama: 'Sazanov LA, Zaǐtsev S. Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biochemistry (Moscow). 1992;57(10):1443-1460.' apa: 'Sazanov, L. A., & Zaǐtsev, S. (1992). Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biochemistry (Moscow). Izdatel’stvo Nauka.' chicago: 'Sazanov, Leonid A, and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14) M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.” Biochemistry (Moscow). Izdatel’stvo Nauka, 1992.' ieee: 'L. A. Sazanov and S. Zaǐtsev, “Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms,” Biochemistry (Moscow), vol. 57, no. 10. Izdatel’stvo Nauka, pp. 1443–1460, 1992.' ista: 'Sazanov LA, Zaǐtsev S. 1992. Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biochemistry (Moscow). 57(10), 1443–1460.' mla: 'Sazanov, Leonid A., and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14) M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.” Biochemistry (Moscow), vol. 57, no. 10, Izdatel’stvo Nauka, 1992, pp. 1443–60.' short: L.A. Sazanov, S. Zaǐtsev, Biochemistry (Moscow) 57 (1992) 1443–1460. date_created: 2018-12-11T11:54:51Z date_published: 1992-10-10T00:00:00Z date_updated: 2022-03-21T10:47:19Z day: '10' extern: '1' external_id: pmid: - '1457592 ' intvolume: ' 57' issue: '10' language: - iso: eng main_file_link: - url: https://europepmc.org/article/med/1457592 month: '10' oa_version: None page: 1443 - 1460 pmid: 1 publication: Biochemistry (Moscow) publication_identifier: issn: - 0006-2979 publication_status: published publisher: Izdatel'stvo Nauka publist_id: '5138' quality_controlled: '1' status: public title: 'Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 57 year: '1992' ... --- _id: '2486' abstract: - lang: eng text: Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1), which is linked to phosphoinositide (PI) hydrolysis, was investigated in adult and developing rat central nervous system (CNS) by in situ hybridization. Transcripts of mGluR1 were specifically localized to neurons and widely distributed throughout the adult rat brain. Most intensely labeled neurons were Purkinje cells of the cerebellum, mitral and tufted cells of the olfactory bulb, and neurons in the hippocampus, lateral septum, thalamus, globus pallidus, entopeduncular nucleus, ventral pallidum, magnocellular preoptic nucleus, substantia nigra, and dorsal cochlear nucleus. Moderately labeled neurons were seen in high density in the dentate gyrus, striatum, islands of Calleja, superficial layers of the retrosplenial, cingulate and entorhinal cortices, mammillary nuclei, red nucleus, and superior colliculus. In the developing rat brain, the level of mGluR1 expression gradually increased during early postnatal days in accordance with the maturation of neuronal elements. These results show prominent expression of mGluR1 in the major targets of putative glutamatergic pathways and unique distribution pattern of mGluR1 distinct from those reported for ionotropic subtypes of glutamate receptors, suggesting specific roles of mGluR1 in the glutamatergic system. acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help. This work was supported in part by research grants from Senri Life Science Foundation and the Ministry of Education, Science and Culture of Japan. article_processing_charge: No article_type: original author: - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi - first_name: Noboru full_name: Mizuno, Noboru last_name: Mizuno citation: ama: 'Shigemoto R, Nakanishi S, Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. Journal of Comparative Neurology. 1992;322(1):121-135. doi:10.1002/cne.903220110' apa: 'Shigemoto, R., Nakanishi, S., & Mizuno, N. (1992). Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.903220110' chicago: 'Shigemoto, Ryuichi, Shigetada Nakanishi, and Noboru Mizuno. “Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR1) in the Central Nervous System: An in Situ Hybridization Study in Adult and Developing Rat.” Journal of Comparative Neurology. Wiley-Blackwell, 1992. https://doi.org/10.1002/cne.903220110.' ieee: 'R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat,” Journal of Comparative Neurology, vol. 322, no. 1. Wiley-Blackwell, pp. 121–135, 1992.' ista: 'Shigemoto R, Nakanishi S, Mizuno N. 1992. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. Journal of Comparative Neurology. 322(1), 121–135.' mla: 'Shigemoto, Ryuichi, et al. “Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR1) in the Central Nervous System: An in Situ Hybridization Study in Adult and Developing Rat.” Journal of Comparative Neurology, vol. 322, no. 1, Wiley-Blackwell, 1992, pp. 121–35, doi:10.1002/cne.903220110.' short: R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 322 (1992) 121–135. date_created: 2018-12-11T11:57:57Z date_published: 1992-08-01T00:00:00Z date_updated: 2022-03-21T09:41:37Z day: '01' doi: 10.1002/cne.903220110 extern: '1' external_id: pmid: - '1430307' intvolume: ' 322' issue: '1' language: - iso: eng main_file_link: - url: https://onlinelibrary.wiley.com/doi/10.1002/cne.903220110 month: '08' oa_version: Published Version page: 121 - 135 pmid: 1 publication: Journal of Comparative Neurology publication_identifier: issn: - 0021-9967 publication_status: published publisher: Wiley-Blackwell publist_id: '4415' quality_controlled: '1' scopus_import: '1' status: public title: 'Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 322 year: '1992' ... --- _id: '2485' abstract: - lang: eng text: Endothelins (ETs) are very potent vasoconstrictive peptides and have diverse functions in both vascular and nonvascular tissues. This investigation concerns the tissue distribution and cellular localization of rat mRNAs encoding two different subtypes of ET receptors (ET(A) and ET(B)). We isolated 46 cDNA clones from a rat lung cDNA library by hybridization with the bovine ET(A) cDNA. The characterization of these cDNA clones indicated that they represent either the ET(A) or ET(B) cDNA. In situ and blot hybridization analyses revealed that the rat ET(A) mRNA is predominantly expressed in vascular smooth muscle cells of a variety of tissues, bronchial smooth muscle cells, myocardium, and the pituitary gland. There is no significant expression of ET(B) mRNA in vascular smooth muscle cells, and ET(A), thus, plays a primary role in ET-induced vascular contraction. ET(B) mRNA is more widely distributed in various cell types of many tissues. Its prominent expression is seen in glial cells throughout the brain regions, epithelial cells of the choroid plexus, ependymal cells lining the ventricle, myocardium, endothelial cells of glomeruli, and epithelial cells of the thin segments of Henle's loops. Our investigation demonstrates that the mRNAs for the two subtypes of rat ET receptors show specialized expression patterns of cell types in both brain and peripheral tissues. article_processing_charge: No article_type: original author: - first_name: Seiji full_name: Hori, Seiji last_name: Hori - first_name: Yasato full_name: Komatsu, Yasato last_name: Komatsu - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Noboru full_name: Mizuno, Noboru last_name: Mizuno - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi citation: ama: Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. Endocrinology. 1992;130(4):1885-1895. doi:10.1210/endo.130.4.1312429 apa: Hori, S., Komatsu, Y., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1992). Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. Endocrinology. The Endocrine Society. https://doi.org/10.1210/endo.130.4.1312429 chicago: Hori, Seiji, Yasato Komatsu, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Distinct Tissue Distribution and Cellular Localization of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors.” Endocrinology. The Endocrine Society, 1992. https://doi.org/10.1210/endo.130.4.1312429. ieee: S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors,” Endocrinology, vol. 130, no. 4. The Endocrine Society, pp. 1885–1895, 1992. ista: Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. 1992. Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. Endocrinology. 130(4), 1885–1895. mla: Hori, Seiji, et al. “Distinct Tissue Distribution and Cellular Localization of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors.” Endocrinology, vol. 130, no. 4, The Endocrine Society, 1992, pp. 1885–95, doi:10.1210/endo.130.4.1312429. short: S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, S. Nakanishi, Endocrinology 130 (1992) 1885–1895. date_created: 2018-12-11T11:57:56Z date_published: 1992-04-01T00:00:00Z date_updated: 2022-03-21T09:54:59Z day: '01' doi: 10.1210/endo.130.4.1312429 extern: '1' external_id: pmid: - '1312429' intvolume: ' 130' issue: '4' language: - iso: eng main_file_link: - url: https://academic.oup.com/endo/article-abstract/130/4/1885/2535978 month: '04' oa_version: None page: 1885 - 1895 pmid: 1 publication: Endocrinology publication_identifier: issn: - 0013-7227 publication_status: published publisher: The Endocrine Society publist_id: '4416' quality_controlled: '1' scopus_import: '1' status: public title: Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 130 year: '1992' ... --- _id: '2484' abstract: - lang: eng text: Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns. acknowledgement: 'We are grateful to Noboru Mizuno for helpful discussion and Akira Uesugi for photographic assistance. This work was sup. ported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC Sec-tion 1734 solely to indicate this fact. ' article_processing_charge: No article_type: original author: - first_name: Yasuto full_name: Tanabe, Yasuto last_name: Tanabe - first_name: Masayuki full_name: Masu, Masayuki last_name: Masu - first_name: Takahiro full_name: Ishii, Takahiro last_name: Ishii - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi citation: ama: Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 1992;8(1):169-179. doi:10.1016/0896-6273(92)90118-W apa: Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992). A family of metabotropic glutamate receptors. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90118-W chicago: Tanabe, Yasuto, Masayuki Masu, Takahiro Ishii, Ryuichi Shigemoto, and Shigetada Nakanishi. “A Family of Metabotropic Glutamate Receptors.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90118-W. ieee: Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, and S. Nakanishi, “A family of metabotropic glutamate receptors,” Neuron, vol. 8, no. 1. Elsevier, pp. 169–179, 1992. ista: Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic glutamate receptors. Neuron. 8(1), 169–179. mla: Tanabe, Yasuto, et al. “A Family of Metabotropic Glutamate Receptors.” Neuron, vol. 8, no. 1, Elsevier, 1992, pp. 169–79, doi:10.1016/0896-6273(92)90118-W. short: Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, S. Nakanishi, Neuron 8 (1992) 169–179. date_created: 2018-12-11T11:57:56Z date_published: 1992-01-01T00:00:00Z date_updated: 2022-03-21T10:17:07Z day: '01' doi: 10.1016/0896-6273(92)90118-W extern: '1' external_id: pmid: - '1309649 ' intvolume: ' 8' issue: '1' language: - iso: eng main_file_link: - url: https://www.sciencedirect.com/science/article/pii/089662739290118W?via%3Dihub month: '01' oa_version: None page: 169 - 179 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier publist_id: '4417' quality_controlled: '1' scopus_import: '1' status: public title: A family of metabotropic glutamate receptors type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 8 year: '1992' ... --- _id: '2533' abstract: - lang: eng text: A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic glutamate receptor (mGluR) family and by the subsequent screening of a rat brain cDNA library. The cloned receptor consists of 1171 amino acid residues and exhibits a structural architecture common to the mGluR family, possessing a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR5 shows the highest sequence similarity to mGluR1 among the mGluR members and is coupled to the stimulation of phosphatidylinositol hydrolysis/ Ca2+ signal transduction in Chinese hamster ovary cells transfected with the cloned cDNA. This receptor also resembles mGluR1 in its agonist selectivity and antagonist responses; the potency rank order of agonists for mGluR5 was determined to be quisqualate > L-glutamate ≥ ibotenate > trans-1-aminocyclopentane-1,3-dicarboxylate. Blot and in situ hybridization analyses indicated that mGluR5 mRNA is widely distributed in neuronal cells of the central nervous system and is expressed differently from mGluR1 mRNA in many brain regions. This investigation thus demonstrates that there is an additional mGluR subtype which closely resembles mGluR1 in its signal transduction and pharmacological properties and is expressed in specialized neuronal cells in the central nervous system. acknowledgement: We are grateful to Seiji Ito for help of Ca2+ measurements and Akira Uesugi for photographic assistance. article_processing_charge: No article_type: original author: - first_name: Takaaki full_name: Abe, Takaaki last_name: Abe - first_name: Hidemitsu full_name: Sugihara, Hidemitsu last_name: Sugihara - first_name: Hiroyuki full_name: Nawa, Hiroyuki last_name: Nawa - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Noboru full_name: Mizuno, Noboru last_name: Mizuno - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi citation: ama: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry. 1992;267(19):13361-13368. doi:10.1016/S0021-9258(18)42219-3 apa: Abe, T., Sugihara, H., Nawa, H., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1992). Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/S0021-9258(18)42219-3 chicago: Abe, Takaaki, Hidemitsu Sugihara, Hiroyuki Nawa, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a Novel Metabotropic Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 1992. https://doi.org/10.1016/S0021-9258(18)42219-3. ieee: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction,” Journal of Biological Chemistry, vol. 267, no. 19. American Society for Biochemistry and Molecular Biology, pp. 13361–13368, 1992. ista: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1992. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry. 267(19), 13361–13368. mla: Abe, Takaaki, et al. “Molecular Characterization of a Novel Metabotropic Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” Journal of Biological Chemistry, vol. 267, no. 19, American Society for Biochemistry and Molecular Biology, 1992, pp. 13361–68, doi:10.1016/S0021-9258(18)42219-3. short: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal of Biological Chemistry 267 (1992) 13361–13368. date_created: 2018-12-11T11:58:14Z date_published: 1992-07-05T00:00:00Z date_updated: 2022-03-17T15:08:29Z day: '05' doi: 10.1016/S0021-9258(18)42219-3 extern: '1' external_id: pmid: - '1320017' intvolume: ' 267' issue: '19' language: - iso: eng main_file_link: - open_access: '1' url: https://www.sciencedirect.com/science/article/pii/S0021925818422193 month: '07' oa: 1 oa_version: Published Version page: 13361 - 13368 pmid: 1 publication: Journal of Biological Chemistry publication_identifier: issn: - 0021-9258 publication_status: published publisher: American Society for Biochemistry and Molecular Biology publist_id: '4366' quality_controlled: '1' scopus_import: '1' status: public title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 267 year: '1992' ... --- _id: '2535' abstract: - lang: eng text: We report the molecular characterization of two novel rat helix-loop-helix (HLH) proteins, designated HES-1 and HES-3, that show structural homology to the Drosophila hairy and Enhancer of split [E(spl)] proteins, both of which are required for normal neurogenesis. HES-1 mRNA, expressed in various tissues of both embryos and adults, is present at a high level in the epithelial cells, including the embryonal neuroepithelial cells, as well as in the mesoderm-derived tissues such as the embryonal muscle. In contrast, HES-3 mRNA is produced exclusively in cerebellar Purkinje cells. HES-1 represses transcription by binding to the N box, which is a recognition sequence of E(spl) proteins. Interestingly, neither HES-1 nor HES-3 alone interacts efficiently with the E box, but each protein decreases the transcription induced by E-box-binding HLH activators such as E47. Furthermore, HES-1 also inhibits the functions of MyoD and MASH1 and effectively diminishes the myogenic conversion of C3H10T1/2 cells induced by MyoD. These results suggest that HES-1 may play an important role in mammalian development by negatively acting on the two different sequences while HES-3 acts as a repressor in a specific type of neurons. acknowledgement: "We thank Professor Noboru Mizuno for his kind help with in situ hybridization experiments, Akira Uesugi and Dr. Chihiro\r\nAkazawa for photographic assistance, Drs. Elizabeth Knust and Jose A. Campos-Ortega for communicating their unpublished results, Dr. Shinji Fushiki for useful discussion, Dr. Mikio Nishizawa and Professor Shigekazu Nagata for pMNT, Dr. David Baltimore for the E47 expression vector, Drs. Yoichiro Nabeshima and Atsuko Fujisawa for the MyoD expression vector and the reporter plasmid with the MCK enhancer, and Dr. Makoto Ishibashi for his help in isolating the human E47 eDNA clone. This work was supported in part by research grants from the Ministry of Education, Science, and Culture of Japan. The publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked \"advertisement\" in accordance with 18 USC section 1734 solely to indicate this fact. \r\n" article_processing_charge: No article_type: original author: - first_name: Yoshiki full_name: Sasai, Yoshiki last_name: Sasai - first_name: Ryoichiro full_name: Kageyama, Ryoichiro last_name: Kageyama - first_name: Yoshiaki full_name: Tagawa, Yoshiaki last_name: Tagawa - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi citation: ama: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes and Development. 1992;6(12 B):2620-2634. doi:10.1101/gad.6.12b.2620 apa: Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R., & Nakanishi, S. (1992). Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.6.12b.2620 chicago: Sasai, Yoshiki, Ryoichiro Kageyama, Yoshiaki Tagawa, Ryuichi Shigemoto, and Shigetada Nakanishi. “Two Mammalian Helix-Loop-Helix Factors Structurally Related to Drosophila Hairy and Enhancer of Split.” Genes and Development. Cold Spring Harbor Laboratory Press, 1992. https://doi.org/10.1101/gad.6.12b.2620. ieee: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, and S. Nakanishi, “Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split,” Genes and Development, vol. 6, no. 12 B. Cold Spring Harbor Laboratory Press, pp. 2620–2634, 1992. ista: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. 1992. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes and Development. 6(12 B), 2620–2634. mla: Sasai, Yoshiki, et al. “Two Mammalian Helix-Loop-Helix Factors Structurally Related to Drosophila Hairy and Enhancer of Split.” Genes and Development, vol. 6, no. 12 B, Cold Spring Harbor Laboratory Press, 1992, pp. 2620–34, doi:10.1101/gad.6.12b.2620. short: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, S. Nakanishi, Genes and Development 6 (1992) 2620–2634. date_created: 2018-12-11T11:58:15Z date_published: 1992-01-01T00:00:00Z date_updated: 2022-03-17T14:52:29Z day: '01' doi: 10.1101/gad.6.12b.2620 extern: '1' external_id: pmid: - '1340473' intvolume: ' 6' issue: 12 B language: - iso: eng main_file_link: - open_access: '1' url: http://genesdev.cshlp.org/content/6/12b/2620 month: '01' oa: 1 oa_version: Published Version page: 2620 - 2634 pmid: 1 publication: Genes and Development publication_identifier: issn: - 0890-9369 publication_status: published publisher: Cold Spring Harbor Laboratory Press publist_id: '4364' quality_controlled: '1' scopus_import: '1' status: public title: Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 6 year: '1992' ... --- _id: '2532' abstract: - lang: eng text: In the present study, we have investigated the expression of both the erythrocyte-type (GLUT1) and the brain-type (GLUT3) glucose transporter isoforms in primary human brain tumors. In situ hybridization made it possible to localize and semiquantify both GLUT1 and GLUT3 mRNAs of individual cells in all 18 samples examined. More signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocytoma cells, while the reverse was the case in all 6 meningiomas. In astrocytomas, for both mRNAs, the density of silver grains over tumor cells was well correlated with the malignancy of the cells. This correlation was, as was also confirmed by Northern blot analysis, more marked with GLUT3 mRNA than with GLUT1 mRNA. In 2 of 5 anaplastic astrocytomas and in all 3 glioblastomas, numerous tumor cells with large amounts of both mRNAs tended to surround the perivascular regions. 'Tumor vessels' with endothelial proliferation, an almost pathognomonic feature of glioblastomas, expressed much GLUT3 mRNA but no significant GLUT1 mRNA, while a single- or a few-layered capillary endothelium expressed much GLUT1 mRNA. The distribution of both mRNAs was in good accordance with that of both proteins. Our results suggest that the expression of both glucose transporter isoforms may contribute to the maintenance of human brain tumors and that the expression of the GLUT3 isoform may be closely related to the malignant change of astrocytomas and particularly related to the aberrant neovascularization which accompanies glioblastomas. acknowledgement: 'We wish to acknowledge generous donations of human samples by the following neurosurgeons: Drs. Taro Fukumitsu. Akinori Kondo, Toyoshiro Yamamoto, Juji Takeuchi, Junya Hanakita, Syunichi Yoneda, and Michio Nishikawa. We are very grateful to Dr. G. I. Bell (The University of Chicago) for providing the cDNA clones of GLUTI and GLUT3. We thank Drs. Yoshifumi Yokota, Yuichiro Yamada. and Manabu Fukumoto for their helpful advice. We also thank Yoshinobu Toda and Hiroko Sato for their expert technical assistance. Supported in part by Grants in Aids for Basic Research on Radiation Therapy (03151034) and Special Project Research on Cancer Bio-Science from the Ministry of Education, Science, and Culture of Japan, by Takeda Medical Foundation, and by Monbusho International Scientific Research: Joint Research.' article_processing_charge: No article_type: original author: - first_name: Tatsuya full_name: Nishioka, Tatsuya last_name: Nishioka - first_name: Yoshifumi full_name: Oda, Yoshifumi last_name: Oda - first_name: Yutaka full_name: Seino, Yutaka last_name: Seino - first_name: Taizo full_name: Yamamoto, Taizo last_name: Yamamoto - first_name: Nobuya full_name: Inagaki, Nobuya last_name: Inagaki - first_name: Hideki full_name: Yano, Hideki last_name: Yano - first_name: Hiroo full_name: Imura, Hiroo last_name: Imura - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Haruhiko full_name: Kikuchi, Haruhiko last_name: Kikuchi citation: ama: Nishioka T, Oda Y, Seino Y, et al. Distribution of the glucose transporters in human brain tumors. Cancer Research. 1992;52(14):3972-3979. apa: Nishioka, T., Oda, Y., Seino, Y., Yamamoto, T., Inagaki, N., Yano, H., … Kikuchi, H. (1992). Distribution of the glucose transporters in human brain tumors. Cancer Research. American Association for Cancer Research. chicago: Nishioka, Tatsuya, Yoshifumi Oda, Yutaka Seino, Taizo Yamamoto, Nobuya Inagaki, Hideki Yano, Hiroo Imura, Ryuichi Shigemoto, and Haruhiko Kikuchi. “Distribution of the Glucose Transporters in Human Brain Tumors.” Cancer Research. American Association for Cancer Research, 1992. ieee: T. Nishioka et al., “Distribution of the glucose transporters in human brain tumors,” Cancer Research, vol. 52, no. 14. American Association for Cancer Research, pp. 3972–3979, 1992. ista: Nishioka T, Oda Y, Seino Y, Yamamoto T, Inagaki N, Yano H, Imura H, Shigemoto R, Kikuchi H. 1992. Distribution of the glucose transporters in human brain tumors. Cancer Research. 52(14), 3972–3979. mla: Nishioka, Tatsuya, et al. “Distribution of the Glucose Transporters in Human Brain Tumors.” Cancer Research, vol. 52, no. 14, American Association for Cancer Research, 1992, pp. 3972–79. short: T. Nishioka, Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura, R. Shigemoto, H. Kikuchi, Cancer Research 52 (1992) 3972–3979. date_created: 2018-12-11T11:58:13Z date_published: 1992-01-01T00:00:00Z date_updated: 2022-03-17T15:38:42Z day: '01' extern: '1' external_id: pmid: - '1617673' intvolume: ' 52' issue: '14' language: - iso: eng main_file_link: - url: https://aacrjournals.org/cancerres/article/52/14/3972/497930/Distribution-of-the-Glucose-Transporters-in-Human month: '01' oa_version: None page: 3972 - 3979 pmid: 1 publication: Cancer Research publication_identifier: issn: - 0008-5472 publication_status: published publisher: American Association for Cancer Research publist_id: '4367' quality_controlled: '1' scopus_import: '1' status: public title: Distribution of the glucose transporters in human brain tumors type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 52 year: '1992' ... --- _id: '2534' abstract: - lang: eng text: Vasoactive intestinal polypeptide (VIP), a 28 amino acid peptide hormone, plays many physiological roles in the peripheral and central nerve systems. A functional cDNA clone of the VIP receptor was isolated from a rat lung cDNA library by cross-hybridization with the secretin receptor cDNA. VIP bound the cloned VIP receptor expressed in mouse COP cells and stimulated adenylate cyclase through the cloned receptor. The rat VIP receptor consists of 459 amino acids with a calculated Mr of 52,054 and contains seven transmembrane segments. It is structurally related to the secretin, calcitonin, and parathyroid hormone receptors, suggesting that they constitute a new subfamily of the G5 protein - coupled receptors. VIP receptor mRNA was detected in various rat tissues including liver, lung, intestines, and brain. In situ hybridization revealed that VIP receptor mRNA is widely distributed in neuronal cells of the adult rat brain, with a relatively high expression in the cerebral cortex and hippocampus. acknowledgement: "We thank Drs. R. Yoshida, K. Katoh, and K. lmamura for help with the in situ hybridization, Dr. M. Nishizawa for discussion, and Ms. M. lkeda for secretarial assistance. This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part\r\nby the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact." article_processing_charge: No article_type: original author: - first_name: Takeshi full_name: Ishihara, Takeshi last_name: Ishihara - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Kensaku full_name: Mori, Kensaku last_name: Mori - first_name: Kenji full_name: Takahashi, Kenji last_name: Takahashi - first_name: Shigekazu full_name: Nagata, Shigekazu last_name: Nagata citation: ama: Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. 1992;8(4):811-819. doi:10.1016/0896-6273(92)90101-I apa: Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., & Nagata, S. (1992). Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90101-I chicago: Ishihara, Takeshi, Ryuichi Shigemoto, Kensaku Mori, Kenji Takahashi, and Shigekazu Nagata. “Functional Expression and Tissue Distribution of a Novel Receptor for Vasoactive Intestinal Polypeptide.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90101-I. ieee: T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, and S. Nagata, “Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide,” Neuron, vol. 8, no. 4. Elsevier, pp. 811–819, 1992. ista: Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. 1992. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. 8(4), 811–819. mla: Ishihara, Takeshi, et al. “Functional Expression and Tissue Distribution of a Novel Receptor for Vasoactive Intestinal Polypeptide.” Neuron, vol. 8, no. 4, Elsevier, 1992, pp. 811–19, doi:10.1016/0896-6273(92)90101-I. short: T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, S. Nagata, Neuron 8 (1992) 811–819. date_created: 2018-12-11T11:58:14Z date_published: 1992-04-01T00:00:00Z date_updated: 2022-03-17T13:33:07Z day: '01' doi: 10.1016/0896-6273(92)90101-I extern: '1' external_id: pmid: - '1314625' intvolume: ' 8' issue: '4' language: - iso: eng main_file_link: - url: https://www.sciencedirect.com/science/article/pii/089662739290101I?via%3Dihub month: '04' oa_version: None page: 811 - 819 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier publist_id: '4363' quality_controlled: '1' scopus_import: '1' status: public title: Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 8 year: '1992' ... --- _id: '2531' abstract: - lang: eng text: The distribution of NMDA receptor (NMDAR1) on neurons in the peripheral ganglia was examined in the adult rat by in situ hybridization. NMDAR1 mRNA was expressed in all neurons in the sensory and autonomic ganglia examined; in the dorsal root, trigeminal, nodose, superior cervical, and sphenopalatine ganglia. Possible roles of the NMDA receptor on the sensory and autonomic ganglion neurons are discussed. acknowledgement: The photographic help of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by research grants from the Ministry of Education, Science and Culture of Japan. article_processing_charge: No article_type: original author: - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Hitoshi full_name: Ohishi, Hitoshi last_name: Ohishi - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi - first_name: Noboru full_name: Mizuno, Noboru last_name: Mizuno citation: ama: Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. Neuroscience Letters. 1992;144(1-2):229-232. doi:10.1016/0304-3940(92)90756-W apa: Shigemoto, R., Ohishi, H., Nakanishi, S., & Mizuno, N. (1992). Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(92)90756-W chicago: Shigemoto, Ryuichi, Hitoshi Ohishi, Shigetada Nakanishi, and Noboru Mizuno. “Expression of the MRNA for the Rat NMDA Receptor (NMDAR1) in the Sensory and Autonomic Ganglion Neurons.” Neuroscience Letters. Elsevier, 1992. https://doi.org/10.1016/0304-3940(92)90756-W. ieee: R. Shigemoto, H. Ohishi, S. Nakanishi, and N. Mizuno, “Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons,” Neuroscience Letters, vol. 144, no. 1–2. Elsevier, pp. 229–232, 1992. ista: Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. 1992. Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. Neuroscience Letters. 144(1–2), 229–232. mla: Shigemoto, Ryuichi, et al. “Expression of the MRNA for the Rat NMDA Receptor (NMDAR1) in the Sensory and Autonomic Ganglion Neurons.” Neuroscience Letters, vol. 144, no. 1–2, Elsevier, 1992, pp. 229–32, doi:10.1016/0304-3940(92)90756-W. short: R. Shigemoto, H. Ohishi, S. Nakanishi, N. Mizuno, Neuroscience Letters 144 (1992) 229–232. date_created: 2018-12-11T11:58:13Z date_published: 1992-09-14T00:00:00Z date_updated: 2022-03-18T13:15:02Z day: '14' doi: 10.1016/0304-3940(92)90756-W extern: '1' external_id: pmid: - '1436707' intvolume: ' 144' issue: 1-2 language: - iso: eng main_file_link: - url: https://www.sciencedirect.com/science/article/pii/030439409290756W month: '09' oa_version: None page: 229 - 232 pmid: 1 publication: Neuroscience Letters publication_identifier: issn: - 0304-3940 publication_status: published publisher: Elsevier publist_id: '4368' quality_controlled: '1' scopus_import: '1' status: public title: Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 144 year: '1992' ... --- _id: '2714' article_processing_charge: No article_type: original author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 citation: ama: Erdös L. On some problems of P. Turán concerning power sums of complex numbers. Acta Mathematica Hungarica. 1992;59(1-2):11-24. doi:10.1007/BF00052086 apa: Erdös, L. (1992). On some problems of P. Turán concerning power sums of complex numbers. Acta Mathematica Hungarica. Springer. https://doi.org/10.1007/BF00052086 chicago: Erdös, László. “On Some Problems of P. Turán Concerning Power Sums of Complex Numbers.” Acta Mathematica Hungarica. Springer, 1992. https://doi.org/10.1007/BF00052086. ieee: L. Erdös, “On some problems of P. Turán concerning power sums of complex numbers,” Acta Mathematica Hungarica, vol. 59, no. 1–2. Springer, pp. 11–24, 1992. ista: Erdös L. 1992. On some problems of P. Turán concerning power sums of complex numbers. Acta Mathematica Hungarica. 59(1–2), 11–24. mla: Erdös, László. “On Some Problems of P. Turán Concerning Power Sums of Complex Numbers.” Acta Mathematica Hungarica, vol. 59, no. 1–2, Springer, 1992, pp. 11–24, doi:10.1007/BF00052086. short: L. Erdös, Acta Mathematica Hungarica 59 (1992) 11–24. date_created: 2018-12-11T11:59:13Z date_published: 1992-03-01T00:00:00Z date_updated: 2022-03-16T15:33:08Z day: '01' doi: 10.1007/BF00052086 extern: '1' intvolume: ' 59' issue: 1-2 language: - iso: eng main_file_link: - url: https://link.springer.com/article/10.1007/BF00052086 month: '03' oa_version: None page: 11 - 24 publication: Acta Mathematica Hungarica publication_identifier: issn: - 0001-5954 publication_status: published publisher: Springer publist_id: '4182' quality_controlled: '1' scopus_import: '1' status: public title: On some problems of P. Turán concerning power sums of complex numbers type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 59 year: '1992' ...