[{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Sazanov, Leonid A., and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14) M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.” Biochemistry (Moscow), vol. 57, no. 10, Izdatel’stvo Nauka, 1992, pp. 1443–60.","apa":"Sazanov, L. A., & Zaǐtsev, S. (1992). Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biochemistry (Moscow). Izdatel’stvo Nauka.","ama":"Sazanov LA, Zaǐtsev S. Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biochemistry (Moscow). 1992;57(10):1443-1460.","ieee":"L. A. Sazanov and S. Zaǐtsev, “Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms,” Biochemistry (Moscow), vol. 57, no. 10. Izdatel’stvo Nauka, pp. 1443–1460, 1992.","short":"L.A. Sazanov, S. Zaǐtsev, Biochemistry (Moscow) 57 (1992) 1443–1460.","chicago":"Sazanov, Leonid A, and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14) M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.” Biochemistry (Moscow). Izdatel’stvo Nauka, 1992.","ista":"Sazanov LA, Zaǐtsev S. 1992. Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biochemistry (Moscow). 57(10), 1443–1460."},"title":"Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms","article_processing_charge":"No","external_id":{"pmid":["1457592 "]},"author":[{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A","full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","last_name":"Sazanov"},{"first_name":"Sergei","full_name":"Zaǐtsev, Sergei","last_name":"Zaǐtsev"}],"publist_id":"5138","publisher":"Izdatel'stvo Nauka","quality_controlled":"1","publication":"Biochemistry (Moscow)","day":"10","year":"1992","date_created":"2018-12-11T11:54:51Z","date_published":"1992-10-10T00:00:00Z","page":"1443 - 1460","_id":"1945","status":"public","type":"journal_article","article_type":"original","extern":"1","date_updated":"2022-03-21T10:47:19Z","oa_version":"None","pmid":1,"abstract":[{"text":"The effects of ultra-low (10(-18)-10(-14) M) doses (ULD) of biologically active substances have been reviewed in terms of common regularities of ULD effects and peculiarities of action of various groups of compounds. The most common and at the same time paradoxical regularities of ULD action are bi- or polymodal patterns of dose dependence, absence or presence of an inverse effect at higher doses, and instability of ULD effect. Possible mechanisms of ULD action including the mechanism based on the adaptation theory are discussed.","lang":"eng"}],"intvolume":" 57","month":"10","main_file_link":[{"url":"https://europepmc.org/article/med/1457592"}],"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0006-2979"]},"volume":57,"issue":"10"},{"publisher":"Wiley-Blackwell","quality_controlled":"1","acknowledgement":"We are grateful to Mr. Akira Uesugi for photographic help. This work was supported in part by research grants from Senri Life Science Foundation and the Ministry of Education, Science and Culture of Japan.","page":"121 - 135","date_created":"2018-12-11T11:57:57Z","date_published":"1992-08-01T00:00:00Z","doi":"10.1002/cne.903220110","year":"1992","publication":"Journal of Comparative Neurology","day":"01","article_processing_charge":"No","external_id":{"pmid":["1430307"]},"publist_id":"4415","author":[{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Shigetada","full_name":"Nakanishi, Shigetada","last_name":"Nakanishi"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}],"title":"Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat","citation":{"chicago":"Shigemoto, Ryuichi, Shigetada Nakanishi, and Noboru Mizuno. “Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR1) in the Central Nervous System: An in Situ Hybridization Study in Adult and Developing Rat.” Journal of Comparative Neurology. Wiley-Blackwell, 1992. https://doi.org/10.1002/cne.903220110.","ista":"Shigemoto R, Nakanishi S, Mizuno N. 1992. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. Journal of Comparative Neurology. 322(1), 121–135.","mla":"Shigemoto, Ryuichi, et al. “Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR1) in the Central Nervous System: An in Situ Hybridization Study in Adult and Developing Rat.” Journal of Comparative Neurology, vol. 322, no. 1, Wiley-Blackwell, 1992, pp. 121–35, doi:10.1002/cne.903220110.","short":"R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 322 (1992) 121–135.","ieee":"R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat,” Journal of Comparative Neurology, vol. 322, no. 1. Wiley-Blackwell, pp. 121–135, 1992.","apa":"Shigemoto, R., Nakanishi, S., & Mizuno, N. (1992). Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.903220110","ama":"Shigemoto R, Nakanishi S, Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. Journal of Comparative Neurology. 1992;322(1):121-135. doi:10.1002/cne.903220110"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/cne.903220110"}],"scopus_import":"1","intvolume":" 322","month":"08","abstract":[{"lang":"eng","text":"Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1), which is linked to phosphoinositide (PI) hydrolysis, was investigated in adult and developing rat central nervous system (CNS) by in situ hybridization. Transcripts of mGluR1 were specifically localized to neurons and widely distributed throughout the adult rat brain. Most intensely labeled neurons were Purkinje cells of the cerebellum, mitral and tufted cells of the olfactory bulb, and neurons in the hippocampus, lateral septum, thalamus, globus pallidus, entopeduncular nucleus, ventral pallidum, magnocellular preoptic nucleus, substantia nigra, and dorsal cochlear nucleus. Moderately labeled neurons were seen in high density in the dentate gyrus, striatum, islands of Calleja, superficial layers of the retrosplenial, cingulate and entorhinal cortices, mammillary nuclei, red nucleus, and superior colliculus. In the developing rat brain, the level of mGluR1 expression gradually increased during early postnatal days in accordance with the maturation of neuronal elements. These results show prominent expression of mGluR1 in the major targets of putative glutamatergic pathways and unique distribution pattern of mGluR1 distinct from those reported for ionotropic subtypes of glutamate receptors, suggesting specific roles of mGluR1 in the glutamatergic system."}],"pmid":1,"oa_version":"Published Version","issue":"1","volume":322,"publication_status":"published","publication_identifier":{"issn":["0021-9967"]},"language":[{"iso":"eng"}],"type":"journal_article","article_type":"original","status":"public","_id":"2486","date_updated":"2022-03-21T09:41:37Z","extern":"1"},{"publication_status":"published","publication_identifier":{"issn":["0013-7227"]},"language":[{"iso":"eng"}],"volume":130,"issue":"4","abstract":[{"text":"Endothelins (ETs) are very potent vasoconstrictive peptides and have diverse functions in both vascular and nonvascular tissues. This investigation concerns the tissue distribution and cellular localization of rat mRNAs encoding two different subtypes of ET receptors (ET(A) and ET(B)). We isolated 46 cDNA clones from a rat lung cDNA library by hybridization with the bovine ET(A) cDNA. The characterization of these cDNA clones indicated that they represent either the ET(A) or ET(B) cDNA. In situ and blot hybridization analyses revealed that the rat ET(A) mRNA is predominantly expressed in vascular smooth muscle cells of a variety of tissues, bronchial smooth muscle cells, myocardium, and the pituitary gland. There is no significant expression of ET(B) mRNA in vascular smooth muscle cells, and ET(A), thus, plays a primary role in ET-induced vascular contraction. ET(B) mRNA is more widely distributed in various cell types of many tissues. Its prominent expression is seen in glial cells throughout the brain regions, epithelial cells of the choroid plexus, ependymal cells lining the ventricle, myocardium, endothelial cells of glomeruli, and epithelial cells of the thin segments of Henle's loops. Our investigation demonstrates that the mRNAs for the two subtypes of rat ET receptors show specialized expression patterns of cell types in both brain and peripheral tissues.","lang":"eng"}],"pmid":1,"oa_version":"None","main_file_link":[{"url":"https://academic.oup.com/endo/article-abstract/130/4/1885/2535978"}],"scopus_import":"1","intvolume":" 130","month":"04","date_updated":"2022-03-21T09:54:59Z","extern":"1","_id":"2485","article_type":"original","type":"journal_article","status":"public","year":"1992","publication":"Endocrinology","day":"01","page":"1885 - 1895","date_created":"2018-12-11T11:57:56Z","doi":"10.1210/endo.130.4.1312429","date_published":"1992-04-01T00:00:00Z","publisher":"The Endocrine Society","quality_controlled":"1","citation":{"ama":"Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. Endocrinology. 1992;130(4):1885-1895. doi:10.1210/endo.130.4.1312429","apa":"Hori, S., Komatsu, Y., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1992). Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. Endocrinology. The Endocrine Society. https://doi.org/10.1210/endo.130.4.1312429","short":"S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, S. Nakanishi, Endocrinology 130 (1992) 1885–1895.","ieee":"S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors,” Endocrinology, vol. 130, no. 4. The Endocrine Society, pp. 1885–1895, 1992.","mla":"Hori, Seiji, et al. “Distinct Tissue Distribution and Cellular Localization of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors.” Endocrinology, vol. 130, no. 4, The Endocrine Society, 1992, pp. 1885–95, doi:10.1210/endo.130.4.1312429.","ista":"Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. 1992. Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. Endocrinology. 130(4), 1885–1895.","chicago":"Hori, Seiji, Yasato Komatsu, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Distinct Tissue Distribution and Cellular Localization of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors.” Endocrinology. The Endocrine Society, 1992. https://doi.org/10.1210/endo.130.4.1312429."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["1312429"]},"publist_id":"4416","author":[{"first_name":"Seiji","full_name":"Hori, Seiji","last_name":"Hori"},{"full_name":"Komatsu, Yasato","last_name":"Komatsu","first_name":"Yasato"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"title":"Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors"},{"issue":"1","volume":8,"publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","language":[{"iso":"eng"}],"scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/089662739290118W?via%3Dihub"}],"month":"01","intvolume":" 8","abstract":[{"text":"Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.","lang":"eng"}],"pmid":1,"oa_version":"None","date_updated":"2022-03-21T10:17:07Z","extern":"1","article_type":"original","type":"journal_article","status":"public","_id":"2484","page":"169 - 179","doi":"10.1016/0896-6273(92)90118-W","date_published":"1992-01-01T00:00:00Z","date_created":"2018-12-11T11:57:56Z","year":"1992","day":"01","publication":"Neuron","publisher":"Elsevier","quality_controlled":"1","acknowledgement":"We are grateful to Noboru Mizuno for helpful discussion and Akira Uesugi for photographic assistance. This work was sup. ported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked \"advertisement\" in accordance with 18 USC Sec-tion 1734 solely to indicate this fact. ","publist_id":"4417","author":[{"last_name":"Tanabe","full_name":"Tanabe, Yasuto","first_name":"Yasuto"},{"first_name":"Masayuki","last_name":"Masu","full_name":"Masu, Masayuki"},{"first_name":"Takahiro","full_name":"Ishii, Takahiro","last_name":"Ishii"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"external_id":{"pmid":["1309649 "]},"article_processing_charge":"No","title":"A family of metabotropic glutamate receptors","citation":{"mla":"Tanabe, Yasuto, et al. “A Family of Metabotropic Glutamate Receptors.” Neuron, vol. 8, no. 1, Elsevier, 1992, pp. 169–79, doi:10.1016/0896-6273(92)90118-W.","ama":"Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 1992;8(1):169-179. doi:10.1016/0896-6273(92)90118-W","apa":"Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992). A family of metabotropic glutamate receptors. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90118-W","ieee":"Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, and S. Nakanishi, “A family of metabotropic glutamate receptors,” Neuron, vol. 8, no. 1. Elsevier, pp. 169–179, 1992.","short":"Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, S. Nakanishi, Neuron 8 (1992) 169–179.","chicago":"Tanabe, Yasuto, Masayuki Masu, Takahiro Ishii, Ryuichi Shigemoto, and Shigetada Nakanishi. “A Family of Metabotropic Glutamate Receptors.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90118-W.","ista":"Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic glutamate receptors. Neuron. 8(1), 169–179."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0021-9258"]},"volume":267,"issue":"19","oa_version":"Published Version","pmid":1,"abstract":[{"text":"A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic glutamate receptor (mGluR) family and by the subsequent screening of a rat brain cDNA library. The cloned receptor consists of 1171 amino acid residues and exhibits a structural architecture common to the mGluR family, possessing a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR5 shows the highest sequence similarity to mGluR1 among the mGluR members and is coupled to the stimulation of phosphatidylinositol hydrolysis/ Ca2+ signal transduction in Chinese hamster ovary cells transfected with the cloned cDNA. This receptor also resembles mGluR1 in its agonist selectivity and antagonist responses; the potency rank order of agonists for mGluR5 was determined to be quisqualate > L-glutamate ≥ ibotenate > trans-1-aminocyclopentane-1,3-dicarboxylate. Blot and in situ hybridization analyses indicated that mGluR5 mRNA is widely distributed in neuronal cells of the central nervous system and is expressed differently from mGluR1 mRNA in many brain regions. This investigation thus demonstrates that there is an additional mGluR subtype which closely resembles mGluR1 in its signal transduction and pharmacological properties and is expressed in specialized neuronal cells in the central nervous system.","lang":"eng"}],"intvolume":" 267","month":"07","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S0021925818422193"}],"scopus_import":"1","extern":"1","date_updated":"2022-03-17T15:08:29Z","_id":"2533","status":"public","article_type":"original","type":"journal_article","publication":"Journal of Biological Chemistry","day":"05","year":"1992","date_created":"2018-12-11T11:58:14Z","doi":"10.1016/S0021-9258(18)42219-3","date_published":"1992-07-05T00:00:00Z","page":"13361 - 13368","acknowledgement":"We are grateful to Seiji Ito for help of Ca2+ measurements and Akira Uesugi for photographic assistance.","oa":1,"quality_controlled":"1","publisher":"American Society for Biochemistry and Molecular Biology","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Abe, Takaaki, et al. “Molecular Characterization of a Novel Metabotropic Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” Journal of Biological Chemistry, vol. 267, no. 19, American Society for Biochemistry and Molecular Biology, 1992, pp. 13361–68, doi:10.1016/S0021-9258(18)42219-3.","ieee":"T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction,” Journal of Biological Chemistry, vol. 267, no. 19. American Society for Biochemistry and Molecular Biology, pp. 13361–13368, 1992.","short":"T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal of Biological Chemistry 267 (1992) 13361–13368.","apa":"Abe, T., Sugihara, H., Nawa, H., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1992). Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/S0021-9258(18)42219-3","ama":"Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry. 1992;267(19):13361-13368. doi:10.1016/S0021-9258(18)42219-3","chicago":"Abe, Takaaki, Hidemitsu Sugihara, Hiroyuki Nawa, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a Novel Metabotropic Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 1992. https://doi.org/10.1016/S0021-9258(18)42219-3.","ista":"Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1992. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry. 267(19), 13361–13368."},"title":"Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction","article_processing_charge":"No","external_id":{"pmid":["1320017"]},"author":[{"last_name":"Abe","full_name":"Abe, Takaaki","first_name":"Takaaki"},{"full_name":"Sugihara, Hidemitsu","last_name":"Sugihara","first_name":"Hidemitsu"},{"full_name":"Nawa, Hiroyuki","last_name":"Nawa","first_name":"Hiroyuki"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"first_name":"Noboru","full_name":"Mizuno, Noboru","last_name":"Mizuno"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"publist_id":"4366"}]