@article{1946, abstract = {An ultra-low dose (10-14 M) of opioid peptide [D-Ala2]methionine enkephalinamide (DAMEA) is found to exert an inhibitory effect on the production of reactive oxygen species (respiratory burst) in human neutrophils. The validity of this phenomenon has been verified in a series of studies that comprised 30 experiments. The inhibition has proved to be statistically significant (P<0.001). The dose-response dependence of the effect (10-15-10-9 M) followed a characteristic biphasic pattern (with the maximum effect at ultra-low doses). An opioid antagonist, naloxone partially blocks the inhibitory effect, which indicates that the DAMEA action is at least partially mediated by opioid receptors.}, author = {Zaǐtsev, Sergei and Sazanov, Leonid A and Koshkin, Aleksei and Sud'Ina, Galina and Varfolomeev, Sergei}, issn = {0014-2956}, journal = {FEBS Letters}, number = {1}, pages = {84 -- 86}, publisher = {Elsevier}, title = {{Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine enkephalinamide}}, doi = {10.1016/0014-5793(91)81109-L}, volume = {291}, year = {1991}, } @article{2483, abstract = {A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.}, author = {Moriyoshi, Koki and Masu, Masayuki and Ishii, Takahiro and Shigemoto, Ryuichi and Mizuno, Noboru and Nakanishi, Shigetada}, issn = {1476-4687}, journal = {Nature}, number = {6348}, pages = {31 -- 37}, publisher = {Nature Publishing Group}, title = {{Molecular cloning and characterization of the rat NMDA receptor}}, doi = {10.1038/354031a0}, volume = {353}, year = {1991}, } @article{2482, abstract = {The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.}, author = {Masu, Masayuki and Tanabe, Yasuto and Tsuchida, Kunihiro and Shigemoto, Ryuichi and Nakanishi, Shigetada}, issn = {1476-4687}, journal = {Nature}, number = {6312}, pages = {760 -- 765}, publisher = {Nature Publishing Group}, title = {{Sequence and expression of a metabotropic glutamate receptor}}, doi = {10.1038/349760a0}, volume = {349}, year = {1991}, } @article{2529, abstract = {The distribution of cerebral cortical neurons sending projection fibers to the nucleus of the solitary tract (NST), and the topographical distribution of axon terminals of cortico-NST fibers within the NST were examined in the cat by two sets of experiments with horseradish peroxidase (HRP) and HRP conjugated with wheat germ agglutinin (WGA-HRP). First, HRP was injected into the NST. In the cerebral cortex of these cats, neuronal cell bodies were labeled retrogradely in the deep pyramidal cell layer (layer V): After HRP injection centered on the rostral or middle part of the NST, HRP-labeled neuronal cell bodies were distributed mainly in the orbital gyrus and caudal part of the intralimbic cortex, and additionally in the rostral part of the anterior sylvian gyrus. After HRP injection centered on the caudal part of the NST, labeled neuronal cell bodies were seen mainly in the caudoventral part of the intralimbic cortex, and additionally in the orbital gyrus, posterior sigmoid gyrus and rostral part of the anterior sylvian gyrus. The labeling in the intralimbic cortex, orbital gyrus and anterior sylvian gyrus was bilateral with a predominantly ipsilateral distribution, while that in the posterior sigmoid gyrus was bilateral with a clear-cut contralateral dominance. In the second set of experiments, WGA-HRP was injected into the cerebral cortical regions where neuronal cell bodies had been retrogradely labeled with HRP injected into the NST: after WGA-HRP injection into the orbital gyrus, presumed axon terminals in the NST were labeled in the rostral two thirds of the nucleus bilaterally with an ipsilateral predominance. After WGA-HRP injection into the rostral part of the anterior sylvian gyrus, a moderate number of presumed axon terminals were labeled throughout the whole rostrocaudal extent of the NST bilaterally with a slight ipsilateral dominance. After WGA-HRP injection into the middle and caudal parts of the anterior sylvian gyrus, no labeling was found in the NST. After WGA-HRP injection into the caudal part of the intralimbic cortex, presumed terminal labeling in the NST was seen throughout the whole rostrocaudal extent of the nucleus bilaterally with a dominant ipsilateral distribution. After WGA-HRP injection into the posterior sigmoid gyrus, however, no terminal labeling was found in the NST. The results indicate that cortico-NST fibers from the orbital gyrus terminate in the rostral two thirds of the NST, while those from the intralimbic cortex and the rostral part of the anterior sylvian gyrus project to the whole rostrocaudal extent of the NST.}, author = {Yasui, Yukihiko and Itoh, Kazuo and Kaneko, Takeshi and Shigemoto, Ryuichi and Mizuno, Noboru}, issn = {1432-1106}, journal = {Experimental Brain Research}, number = {1}, pages = {75 -- 84}, publisher = {Springer}, title = {{Topographical projections from the cerebral cortex to the nucleus of the solitary tract in the cat}}, doi = {10.1007/BF00229988}, volume = {85}, year = {1991}, } @inbook{2530, author = {Nakanishi, Shigetada and Ohkubo, Hiroaki and Kakizuka, Akira and Yokota, Yoshifumi and Shigemoto, Ryuichi and Sasai, Yoshiki and Takumi, Toru}, booktitle = {Recent Progress in Hormone Research}, isbn = {978-0-12-571148-7}, pages = {59 -- 83}, publisher = {The Endocrine Society}, title = {{Molecular characterization of mammalian tachykinin receptors and a possible epithelial potassium channel}}, doi = {10.1016/b978-0-12-571146-3.50007-9}, volume = {46}, year = {1991}, } @inbook{3566, abstract = {This paper proves an O(m2/3n2/3 + m + n) upper bound on the number of incidences between m points and n hyperplanes in four dimensions, assuming all points lie on one side of each hyperplane and the points and hyperplanes satisfy certain natural general position conditions. This result has application to various three-dimensional combinatorial distance problems. For example, it implies the same upper bound for the number of bichromatic minimum distance pairs in a set of m blue and n red points in three-dimensional space. This improves the best previous bound for this problem. © Springer-Verlag Berlin Heidelberg 1990.}, author = {Edelsbrunner, Herbert and Sharir, Micha}, booktitle = {Applied Geometry and Discrete Mathematics: The Victor Klee Festschrift}, isbn = {978-0897913850}, pages = {253 -- 263}, publisher = {American Mathematical Society}, title = {{A hyperplane incidence problem with applications to counting distances}}, volume = {4}, year = {1991}, } @inbook{3567, abstract = {Many computational geometry problems arc exceedingly more difficult if the setting is the (three-dimensional real) space R3 rather than the plane . Most often the reason for this striking increase in complexity is the appearance of new geometric phenomena caused by one-dimensional objects in space. The intention of recent studies on problems for lines in space is to shed light on these new phenomena and their complexities. This paper reviews some of the most important results and shows how they are related to problems in dimensions 2 and 5. }, author = {Edelsbrunner, Herbert}, booktitle = {Discrete & Computational Geometry: Papers from the Dimacs Special Year}, isbn = {9780821865958}, pages = {77 -- 93}, publisher = {Springer}, title = {{Lines in space – A collection of results}}, volume = {6}, year = {1991}, } @article{4052, abstract = {This paper describes an effective procedure for stratifying a real semi-algebraic set into cells of constant description size. The attractive feature of our method is that the number of cells produced is singly exponential in the number of input variables. This compares favorably with the doubly exponential size of Collins' decomposition. Unlike Collins' construction, however, our scheme does not produce a cell complex but only a smooth stratification. Nevertheless, we are able to apply our results in interesting ways to problems of point location and geometric optimization.}, author = {Chazelle, Bernard and Edelsbrunner, Herbert and Guibas, Leonidas and Sharir, Micha}, issn = {1879-2294}, journal = {Theoretical Computer Science}, number = {1}, pages = {77 -- 105}, publisher = {Elsevier}, title = {{A singly exponential stratification scheme for real semi-algebraic varieties and its applications}}, doi = {10.1016/0304-3975(91)90261-Y}, volume = {84}, year = {1991}, } @article{4056, abstract = {This paper proves that for every n ≥ 4 there is a convex n-gon such that the vertices of 2n - 7 vertex pairs are one unit of distance apart. This improves the previously best lower bound of ⌊ (5n - 5) 3⌋ given by Erdo{combining double acute accent}s and Moser if n ≥ 17.}, author = {Edelsbrunner, Herbert and Hajnal, Péter}, issn = {1096-0899}, journal = {Journal of Combinatorial Theory Series A}, number = {2}, pages = {312 -- 316}, publisher = {Elsevier}, title = {{A lower bound on the number of unit distances between the vertices of a convex polygon}}, doi = {10.1016/0097-3165(91)90042-F}, volume = {56}, year = {1991}, } @inproceedings{4054, abstract = {The zone theorem for an arrangement of n hyperplanes in d-dimensional real space says that the total number of faces bounding the cells intersected by another hyperplane is O(n d–1). This result is the basis of a time-optimal incremental algorithm that constructs a hyperplane arrangement and has a host of other algorithmic and combinatorial applications. Unfortunately, the original proof of the zone theorem, for d ge 3, turned out to contain a serious and irreparable error. This paper presents a new proof of the theorem. Our proof is based on an inductive argument, which also applies in the case of pseudo-hyperplane arrangements. We also briefly discuss the fallacies of the old proof along with some ways of partially saving that approach.}, author = {Edelsbrunner, Herbert and Seidel, Raimund and Sharir, Micha}, pages = {108 -- 123}, publisher = {Springer}, title = {{On the zone theorem for hyperplane arrangements}}, doi = {10.1007/BFb0038185}, volume = {555}, year = {1991}, }