---
_id: '2480'
abstract:
- lang: eng
text: Functional cDNA clones for rat neuromedin K receptor were isolated from a
rat brain cDNA library by cross-hybridization with the bovine substance K recepor
cDNA. Injection of the mRNA synthesized in vitro from the cloned cDNA into Xenopus
oocytes elicited electrophysiological responses to tachykinins, with the most
potent sensitivity being to neuromedin K. Ligand-binding displacement in membranes
of mammalian COS cells transfected with the cDNA indicated the rank order of affinity
of the receptor to tachykinins; neuromedin K > substance K > substance P.
The hybridization analysis showed that the neuromedin K receptor mRNA is expressed
in both the brain and the peripheral tissues at different levels. The rat neuromedin
K receptor consists of 452 amino acid residues and belongs to the family of G
protein-coupled receptors, which are thought to have seven transmembrane domains.
The sequence comparison of the rat neuromedin K, substance P, and substance K
receptors revealed that these receptors are highly conserved in the seven transmembrane
domains and the cytoplasmic sides of the receptors. They also show some structural
characteristics, including the common presence of histidine residues in transmembrane
segments V and VI and the difference in the numbers and distributions of serine
and threonine residues as possible phosphorylation sites in the cytoplasmic regions.
This paper thus presents the first comprehensive analysis of the molecular nature
of the multiple peptide receptors that exhibit similar but pharmacologically distinguishable
activities.
acknowledgement: This work was supported in part by research grants from the Ministry
Education, Science and Culture of Japan; the Institute of Physical and Chemical
Research; and the Science and Technology Agency of Japan. The costs of publication
of this article were defrayed in part by the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 USC. Section
1734 solely to indicate this fact.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yoshifumi
full_name: Yokota, Yoshifumi
last_name: Yokota
- first_name: Kunihiro
full_name: Tsuchida, Kunihiro
last_name: Tsuchida
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Shigemoto R, Yokota Y, Tsuchida K, Nakanishi S. Cloning and expression of a
rat neuromedin K receptor cDNA. Journal of Biological Chemistry. 1990;265(2):623-628.
doi:10.1016/s0021-9258(19)40095-1
apa: Shigemoto, R., Yokota, Y., Tsuchida, K., & Nakanishi, S. (1990). Cloning
and expression of a rat neuromedin K receptor cDNA. Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/s0021-9258(19)40095-1
chicago: Shigemoto, Ryuichi, Yoshifumi Yokota, Kunihiro Tsuchida, and Shigetada
Nakanishi. “Cloning and Expression of a Rat Neuromedin K Receptor CDNA.” Journal
of Biological Chemistry. American Society for Biochemistry and Molecular Biology,
1990. https://doi.org/10.1016/s0021-9258(19)40095-1
.
ieee: R. Shigemoto, Y. Yokota, K. Tsuchida, and S. Nakanishi, “Cloning and expression
of a rat neuromedin K receptor cDNA,” Journal of Biological Chemistry,
vol. 265, no. 2. American Society for Biochemistry and Molecular Biology, pp.
623–628, 1990.
ista: Shigemoto R, Yokota Y, Tsuchida K, Nakanishi S. 1990. Cloning and expression
of a rat neuromedin K receptor cDNA. Journal of Biological Chemistry. 265(2),
623–628.
mla: Shigemoto, Ryuichi, et al. “Cloning and Expression of a Rat Neuromedin K Receptor
CDNA.” Journal of Biological Chemistry, vol. 265, no. 2, American Society
for Biochemistry and Molecular Biology, 1990, pp. 623–28, doi:10.1016/s0021-9258(19)40095-1 .
short: R. Shigemoto, Y. Yokota, K. Tsuchida, S. Nakanishi, Journal of Biological
Chemistry 265 (1990) 623–628.
date_created: 2018-12-11T11:57:55Z
date_published: 1990-01-15T00:00:00Z
date_updated: 2022-02-24T11:07:05Z
day: '15'
doi: '10.1016/s0021-9258(19)40095-1 '
extern: '1'
external_id:
pmid:
- '2153106 '
intvolume: ' 265'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925819400951
month: '01'
oa: 1
oa_version: Published Version
page: 623 - 628
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
eissn:
- 1083-351X
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4421'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cloning and expression of a rat neuromedin K receptor cDNA
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 265
year: '1990'
...
---
_id: '2481'
abstract:
- lang: eng
text: The family of mammalian tachykinin receptors consists of substance P receptor
(SPR), neuromedin K receptor (NKR) and substance K receptor (SKR). In this investigation,
tissue and regional distributions of the mRNAs for the three rat tachykinin receptors
were investigated by blot-hybridization and RNase-protection analyses using the
previously cloned receptor cDNAs. SPR mRNA is widely distributed in both the nervous
system and peripheral tissues and is expressed abundantly in the hypothalamus
and olfactory buld, as well as in the urinary bladder, salivary glands and small
and large intestines. In contrast, NKR mRNA is predominantly expressed in the
nervous system, particularly in the cortex, hypothalamus and cerebellum, whereas
SKR mRNA expression is restricted to the peripheral tissues, being abundant in
the urinary bladder, large intestine, stomach and adenal glands. Thus, the mRNAs
for the three tachykinin receptors show distinct patterns of expression between
the nervous system and peripheral tissues. Blot-hybridization analysis in combination
with S1 nuclease protection and primer-extension analyses revealed that there
are two large forms of SKR mRNA expressed commonly in the peripheral tissues,
and two additional small forms of the mRNA expressed specifically in the adrenal
gland and eye. These analyses also showed that the multiple forms of SKR mRNA
differ in the lengths of the 5' mRNA portions, and that the two small forms of
the mRNA, if translated, encode a truncated SKR polypeptide lacking the first
two transmembrane domains. This investigation thus provides the comprehensive
analysis of the distribution and mode of expression of the mRNAs for the multiple
peptide receptors and offers a new basis on which to interpret the diverse functions
of multiple tachykinin peptides in the CNS and peripheral tissues.
acknowledgement: This work was supported in part by research grants from the Ministry
of Education, Science and Culture of Japan, the Ministry of Health and Welfare
of Japan, and the Yamanouchi Foundation for Research on Metabolic Disorders
article_processing_charge: No
article_type: original
author:
- first_name: Kunihiro
full_name: Tsuchida, Kunihiro
last_name: Tsuchida
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yoshifumi
full_name: Yokota, Yoshifumi
last_name: Yokota
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Tsuchida K, Shigemoto R, Yokota Y, Nakanishi S. Tissue distribution and quantitation
of the mRNAs for three rat tachykinin receptors. European Journal of Biochemistry.
1990;193(3):751-757. doi:10.1111/j.1432-1033.1990.tb19396.x
apa: Tsuchida, K., Shigemoto, R., Yokota, Y., & Nakanishi, S. (1990). Tissue
distribution and quantitation of the mRNAs for three rat tachykinin receptors.
European Journal of Biochemistry. Wiley-Blackwell. https://doi.org/10.1111/j.1432-1033.1990.tb19396.x
chicago: Tsuchida, Kunihiro, Ryuichi Shigemoto, Yoshifumi Yokota, and Shigetada
Nakanishi. “Tissue Distribution and Quantitation of the MRNAs for Three Rat Tachykinin
Receptors.” European Journal of Biochemistry. Wiley-Blackwell, 1990. https://doi.org/10.1111/j.1432-1033.1990.tb19396.x.
ieee: K. Tsuchida, R. Shigemoto, Y. Yokota, and S. Nakanishi, “Tissue distribution
and quantitation of the mRNAs for three rat tachykinin receptors,” European
Journal of Biochemistry, vol. 193, no. 3. Wiley-Blackwell, pp. 751–757, 1990.
ista: Tsuchida K, Shigemoto R, Yokota Y, Nakanishi S. 1990. Tissue distribution
and quantitation of the mRNAs for three rat tachykinin receptors. European Journal
of Biochemistry. 193(3), 751–757.
mla: Tsuchida, Kunihiro, et al. “Tissue Distribution and Quantitation of the MRNAs
for Three Rat Tachykinin Receptors.” European Journal of Biochemistry,
vol. 193, no. 3, Wiley-Blackwell, 1990, pp. 751–57, doi:10.1111/j.1432-1033.1990.tb19396.x.
short: K. Tsuchida, R. Shigemoto, Y. Yokota, S. Nakanishi, European Journal of Biochemistry
193 (1990) 751–757.
date_created: 2018-12-11T11:57:55Z
date_published: 1990-03-03T00:00:00Z
date_updated: 2022-02-24T10:20:14Z
day: '03'
doi: 10.1111/j.1432-1033.1990.tb19396.x
extern: '1'
external_id:
pmid:
- '1701145'
intvolume: ' 193'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1990.tb19396.x
month: '03'
oa: 1
oa_version: Published Version
page: 751 - 757
pmid: 1
publication: European Journal of Biochemistry
publication_identifier:
eissn:
- 1432-1033
issn:
- 0014-2956
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4420'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tissue distribution and quantitation of the mRNAs for three rat tachykinin
receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 193
year: '1990'
...
---
_id: '2528'
abstract:
- lang: eng
text: We previously reported a novel rat membrane protein that exhibits a voltage-dependent
potassium channel activity on the basis of molecular cloning combined with an
electrophysiological assay. This protein, termed I(sK) protein, is small and different
from the conventional potassium channel proteins but induces selective permeation
of potassium ions on its expression in Xenopus oocytes. In this investigation,
we examined cellular localization of rat I(sK) protein by preparing three different
types of antibody that specifically reacts with a distinct part of rat I(sK) protein.
Immunohistochemical analysis using these antibody preparations demonstrated that
rat I(sK) protein is confined to the apical membrane portion of epithelial cells
in the proximal tubule of the kidney, the submandibular duct and the uterine endometrium.
The observed tissue distribution of rat I(sK) protein was consistent with that
of the I(sK) protein mRNA determined by blot hybridization analysis. In epithelial
cells, the sodium, potassium-ATPase pump in the basolateral membrane generates
a sodium gradient across the epithelial cell and allows sodium ions to enter the
cell through the apical membrane. Thus, taking into account the cellular localization
of the I(sK) protein, together with its electrophysiological properties, we discussed
a possible function of the I(sK) protein, namely that this protein is involved
in potassium permeation in the apical membrane of epithelial cells through the
depolarizing effect of sodium entry.
article_processing_charge: No
article_type: original
author:
- first_name: Tetsuo
full_name: Sugimoto, Tetsuo
last_name: Sugimoto
- first_name: Yasuto
full_name: Tanabe, Yasuto
last_name: Tanabe
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Masazumi
full_name: Iwai, Masazumi
last_name: Iwai
- first_name: Toru
full_name: Takumi, Toru
last_name: Takumi
- first_name: Hiroaki
full_name: Ohkubo, Hiroaki
last_name: Ohkubo
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: 'Sugimoto T, Tanabe Y, Shigemoto R, et al. Immunohistochemical study of a rat
membrane protein which induces a selective potassium permeation: Its localization
in the apical membrane portion of epithelial cells. Journal of Membrane Biology.
1990;113(1):39-47. doi:10.1007/BF01869604'
apa: 'Sugimoto, T., Tanabe, Y., Shigemoto, R., Iwai, M., Takumi, T., Ohkubo, H.,
& Nakanishi, S. (1990). Immunohistochemical study of a rat membrane protein
which induces a selective potassium permeation: Its localization in the apical
membrane portion of epithelial cells. Journal of Membrane Biology. Springer.
https://doi.org/10.1007/BF01869604'
chicago: 'Sugimoto, Tetsuo, Yasuto Tanabe, Ryuichi Shigemoto, Masazumi Iwai, Toru
Takumi, Hiroaki Ohkubo, and Shigetada Nakanishi. “Immunohistochemical Study of
a Rat Membrane Protein Which Induces a Selective Potassium Permeation: Its Localization
in the Apical Membrane Portion of Epithelial Cells.” Journal of Membrane Biology.
Springer, 1990. https://doi.org/10.1007/BF01869604.'
ieee: 'T. Sugimoto et al., “Immunohistochemical study of a rat membrane protein
which induces a selective potassium permeation: Its localization in the apical
membrane portion of epithelial cells,” Journal of Membrane Biology, vol.
113, no. 1. Springer, pp. 39–47, 1990.'
ista: 'Sugimoto T, Tanabe Y, Shigemoto R, Iwai M, Takumi T, Ohkubo H, Nakanishi
S. 1990. Immunohistochemical study of a rat membrane protein which induces a selective
potassium permeation: Its localization in the apical membrane portion of epithelial
cells. Journal of Membrane Biology. 113(1), 39–47.'
mla: 'Sugimoto, Tetsuo, et al. “Immunohistochemical Study of a Rat Membrane Protein
Which Induces a Selective Potassium Permeation: Its Localization in the Apical
Membrane Portion of Epithelial Cells.” Journal of Membrane Biology, vol.
113, no. 1, Springer, 1990, pp. 39–47, doi:10.1007/BF01869604.'
short: T. Sugimoto, Y. Tanabe, R. Shigemoto, M. Iwai, T. Takumi, H. Ohkubo, S. Nakanishi,
Journal of Membrane Biology 113 (1990) 39–47.
date_created: 2018-12-11T11:58:12Z
date_published: 1990-01-01T00:00:00Z
date_updated: 2022-02-24T09:55:39Z
day: '01'
doi: 10.1007/BF01869604
extern: '1'
external_id:
pmid:
- '2154581'
intvolume: ' 113'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF01869604
month: '01'
oa_version: None
page: 39 - 47
pmid: 1
publication: Journal of Membrane Biology
publication_identifier:
eissn:
- 1432-1424
issn:
- 0022-2631
publication_status: published
publisher: Springer
publist_id: '4371'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Immunohistochemical study of a rat membrane protein which induces a selective
potassium permeation: Its localization in the apical membrane portion of epithelial
cells'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 113
year: '1990'
...
---
_id: '2721'
abstract:
- lang: eng
text: We consider a multidimensional system consisting of a particle of mass M and
radius r (molecule), surrounded by an infinite ideal gas of point particles of
mass m (atoms). The molecule is confined to the unit ball and interacts with its
boundary (barrier) via elastic collision, while the atoms are not affected by
the boundary. We obtain convergence to equilibrium for the molecule from almost
every initial distribution on its position and velocity. Furthermore, we prove
that the infinite composite system of the molecule and the atoms is Bernoulli.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Dao
full_name: Tuyen, Dao
last_name: Tuyen
citation:
ama: Erdös L, Tuyen D. Ergodic properties of the multidimensional rayleigh gas with
a semipermeable barrier. Journal of Statistical Physics. 1990;59(5-6):1589-1602.
doi:10.1007/BF01334766
apa: Erdös, L., & Tuyen, D. (1990). Ergodic properties of the multidimensional
rayleigh gas with a semipermeable barrier. Journal of Statistical Physics.
Springer. https://doi.org/10.1007/BF01334766
chicago: Erdös, László, and Dao Tuyen. “Ergodic Properties of the Multidimensional
Rayleigh Gas with a Semipermeable Barrier.” Journal of Statistical Physics.
Springer, 1990. https://doi.org/10.1007/BF01334766.
ieee: L. Erdös and D. Tuyen, “Ergodic properties of the multidimensional rayleigh
gas with a semipermeable barrier,” Journal of Statistical Physics, vol.
59, no. 5–6. Springer, pp. 1589–1602, 1990.
ista: Erdös L, Tuyen D. 1990. Ergodic properties of the multidimensional rayleigh
gas with a semipermeable barrier. Journal of Statistical Physics. 59(5–6), 1589–1602.
mla: Erdös, László, and Dao Tuyen. “Ergodic Properties of the Multidimensional Rayleigh
Gas with a Semipermeable Barrier.” Journal of Statistical Physics, vol.
59, no. 5–6, Springer, 1990, pp. 1589–602, doi:10.1007/BF01334766.
short: L. Erdös, D. Tuyen, Journal of Statistical Physics 59 (1990) 1589–1602.
date_created: 2018-12-11T11:59:15Z
date_published: 1990-06-01T00:00:00Z
date_updated: 2022-02-24T09:39:29Z
day: '01'
doi: 10.1007/BF01334766
extern: '1'
intvolume: ' 59'
issue: 5-6
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF01334766
month: '06'
oa_version: None
page: 1589 - 1602
publication: Journal of Statistical Physics
publication_identifier:
eissn:
- 1572-9613
issn:
- 0022-4715
publication_status: published
publisher: Springer
publist_id: '4171'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ergodic properties of the multidimensional rayleigh gas with a semipermeable
barrier
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 59
year: '1990'
...
---
_id: '3650'
abstract:
- lang: eng
text: Hybrid zones can yield estimates of natural selection and gene flow. The width
of a cline in gene frequency is approximately proportional to gene flow (σ) divided
by the square root of per-locus selection ( &s). Gene flow also causes gametic
correlations (linkage disequilibria) between genes that differ across hybrid zones.
Correlations are stronger when the hybrid zone is narrow, and rise to a maximum
roughly equal to s. Thus cline width and gametic correlations combine to give
estimates of gene flow and selection. These indirect measures of σ and s are especially
useful because they can be made from collections, and require no field experiments.
The method was applied to hybrid zones between color pattern races in a pair of
Peruvian Heliconius butterfly species. The species are Mullerian mimics of one
another, and both show the same changes in warning color pattern across their
respective hybrid zones. The expectations of cline width and gametic correlation
were generated using simulations of clines stabilized by strong frequency-dependent
selection. In the hybrid zone in Heliconius erato, clines at three major color
pattern loci were between 8.5 and 10.2 km wide, and the pairwise gametic correlations
peaked at R & 0.35. These measures suggest that s & 0.23 per locus, and
that σ & 2.6 km. In erato, the shapes of the clines agreed with that expected
on the basis of dominance. Heliconius melpomene has a nearly coincident hybrid
zone. In this species, cline widths at four major color pattern loci varied between
11.7 and 13.4 km. Pairwise gametic correlations peaked near R & 1.00 for tightly
linked genes, and at R & 0.40 for unlinked genes, giving s & 0.25 per
locus and σ & 3.7 km. In melpomene, cline shapes did not perfectly fit theoretical
shapes based on dominance; this deviation might be explained by long-distance
migration and/or strong epistasis. Compared with erato, sample sizes in melpomene
are lower and the genetics of its color patterns are less well understood. In
spite of these problems, selection and gene flow are clearly of the same order
of magnitude in the two species. The relatively high per locus selection coefficients
agree with ``major gene'' theories for the evolution of Mullerian mimicry, but
the genetic architecture of the color patterns does not. These results show that
the genetics and evolution of mimicry are still only sketchily understood.
acknowledgement: 'We thank the Natural Environmental Research Council, the Royal Society,
the Nuffield Foundation, CONCYTEC, and Mrs. G. W. BORLASE for financial support,
and the people of San Martin for their generous hospitality. We are very grateful
to S. D. KNAPP, who helped by maintaining our sanity and rearing larvae. We are
also grateful to an anonymous reviewer, A. W. PORTER, J. C. SCHNEIDER, M. TURELLI
and C. E. WATSON for helpful comments on the manuscript. This paper was approved
for publication as journal article no. 5-7255 of the Mississippi Agricultural and
Forestry Experiment Station, Mississippi State University, project no. MIS-2 122. '
article_processing_charge: No
article_type: original
author:
- first_name: James
full_name: Mallet, James
last_name: Mallet
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Gerado
full_name: Lamas, Gerado
last_name: Lamas
- first_name: José
full_name: Santisteban, José
last_name: Santisteban
- first_name: Manuel
full_name: Muedas, Manuel
last_name: Muedas
- first_name: Harriet
full_name: Eeley, Harriet
last_name: Eeley
citation:
ama: Mallet J, Barton NH, Lamas G, Santisteban J, Muedas M, Eeley H. Estimates of
selection and gene flow from measures of cline width and linkage disequilibrium
in Heliconius hybrid zones. Genetics. 1990;124(4):921-936. doi:10.1093/genetics/124.4.921
apa: Mallet, J., Barton, N. H., Lamas, G., Santisteban, J., Muedas, M., & Eeley,
H. (1990). Estimates of selection and gene flow from measures of cline width and
linkage disequilibrium in Heliconius hybrid zones. Genetics. Genetics Society
of America. https://doi.org/10.1093/genetics/124.4.921
chicago: Mallet, James, Nicholas H Barton, Gerado Lamas, José Santisteban, Manuel
Muedas, and Harriet Eeley. “Estimates of Selection and Gene Flow from Measures
of Cline Width and Linkage Disequilibrium in Heliconius Hybrid Zones.” Genetics.
Genetics Society of America, 1990. https://doi.org/10.1093/genetics/124.4.921.
ieee: J. Mallet, N. H. Barton, G. Lamas, J. Santisteban, M. Muedas, and H. Eeley,
“Estimates of selection and gene flow from measures of cline width and linkage
disequilibrium in Heliconius hybrid zones,” Genetics, vol. 124, no. 4.
Genetics Society of America, pp. 921–936, 1990.
ista: Mallet J, Barton NH, Lamas G, Santisteban J, Muedas M, Eeley H. 1990. Estimates
of selection and gene flow from measures of cline width and linkage disequilibrium
in Heliconius hybrid zones. Genetics. 124(4), 921–936.
mla: Mallet, James, et al. “Estimates of Selection and Gene Flow from Measures of
Cline Width and Linkage Disequilibrium in Heliconius Hybrid Zones.” Genetics,
vol. 124, no. 4, Genetics Society of America, 1990, pp. 921–36, doi:10.1093/genetics/124.4.921.
short: J. Mallet, N.H. Barton, G. Lamas, J. Santisteban, M. Muedas, H. Eeley, Genetics
124 (1990) 921–936.
date_created: 2018-12-11T12:04:26Z
date_published: 1990-04-01T00:00:00Z
date_updated: 2022-02-23T11:04:17Z
day: '01'
doi: 10.1093/genetics/124.4.921
extern: '1'
external_id:
pmid:
- '2323556'
intvolume: ' 124'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203983/
month: '04'
oa: 1
oa_version: Published Version
page: 921 - 936
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2733'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Estimates of selection and gene flow from measures of cline width and linkage
disequilibrium in Heliconius hybrid zones
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 124
year: '1990'
...
---
_id: '3649'
abstract:
- lang: eng
text: Selection on polygenic characters is generally analyzed by statistical methods
that assume a Gaussian (normal) distribution of breeding values. We present an
alternative analysis based on multilocus population genetics. We use a general
representation of selection, recombination, and drift to analyze an idealized
polygenic system in which all genetic effects are additive (i.e., both dominance
and epistasis are absent), but no assumptions are made about the distribution
of breeding values or the numbers of loci or alleles. Our analysis produces three
results. First, our equations reproduce the standard recursions for the mean and
additive variance if breeding values are Gaussian; but they also reveal how non-Gaussian
distributions of breeding values will alter these dynamics. Second, an approximation
valid for weak selection shows that even if genetic variance is attributable to
an effectively infinite number of loci with only additive effects, selection will
generally drive the distribution of breeding values away from a Gaussian distribution
by creating multilocus linkage disequilibria. Long-term dynamics of means can
depart substantially from the predictions of the standard selection recursions,
but the discrepancy may often be negligible for short-term selection. Third, by
including mutation, we show that, for realistic parameter values, linkage disequilibrium
has little effect on the amount of additive variance maintained at an equilibrium
between stabilizing selection and mutation. Each of these analytical results is
supported by numerical calculations.
acknowledgement: 'We thank R. Burger, J. A. Coyne, W. G. Hill, A. A. Hoffmann, J.
H. Gillespie, M. Slatkin, T. Nagylaki and Z.-B. Zeng for helpful discussions and
comments on earlier drafts. Our research is supported by grants from the National
Science Foundation (BSR-8866548), the Science and Engineering Research Council,
and the Institute of Theoretical Dynamics at UCD. '
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Turelli M, Barton NH. Dynamics of polygenic characters under selection. Theoretical
Population Biology. 1990;38(1):1-57. doi:10.1016/0040-5809(90)90002-D
apa: Turelli, M., & Barton, N. H. (1990). Dynamics of polygenic characters under
selection. Theoretical Population Biology. Academic Press. https://doi.org/10.1016/0040-5809(90)90002-D
chicago: Turelli, Michael, and Nicholas H Barton. “Dynamics of Polygenic Characters
under Selection.” Theoretical Population Biology. Academic Press, 1990.
https://doi.org/10.1016/0040-5809(90)90002-D.
ieee: M. Turelli and N. H. Barton, “Dynamics of polygenic characters under selection,”
Theoretical Population Biology, vol. 38, no. 1. Academic Press, pp. 1–57,
1990.
ista: Turelli M, Barton NH. 1990. Dynamics of polygenic characters under selection.
Theoretical Population Biology. 38(1), 1–57.
mla: Turelli, Michael, and Nicholas H. Barton. “Dynamics of Polygenic Characters
under Selection.” Theoretical Population Biology, vol. 38, no. 1, Academic
Press, 1990, pp. 1–57, doi:10.1016/0040-5809(90)90002-D.
short: M. Turelli, N.H. Barton, Theoretical Population Biology 38 (1990) 1–57.
date_created: 2018-12-11T12:04:26Z
date_published: 1990-01-01T00:00:00Z
date_updated: 2022-02-23T14:48:49Z
day: '01'
doi: 10.1016/0040-5809(90)90002-D
extern: '1'
intvolume: ' 38'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/004058099090002D?via%3Dihub
month: '01'
oa_version: None
page: 1 - 57
publication: Theoretical Population Biology
publication_identifier:
issn:
- 0040-5809
publication_status: published
publisher: Academic Press
publist_id: '2734'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamics of polygenic characters under selection
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 38
year: '1990'
...
---
_id: '3651'
abstract:
- lang: eng
text: 'It is widely held that each gene typically affects many characters, and that
each character is affected by many genes. Moreover, strong stabilizing selection
cannot act on an indefinitely large number of independent traits. This makes it
likely that heritable variation in any one trait is maintained as a side effect
of polymorphisms which have nothing to do with selection on that trait. This paper
examines the idea that variation is maintained as the pleiotropic side effect
of either deleterious mutation, or balancing selection. If mutation is responsible,
it must produce alleles which are only mildly deleterious (s & 10(-3)), but
nevertheless have significant effects on the trait. Balancing selection can readily
maintain high heritabilities; however, selection must be spread over many weakly
selected polymorphisms if large responses to artificial selection are to be possible.
In both classes of pleiotropic model, extreme phenotypes are less fit, giving
the appearance of stabilizing selection on the trait. However, it is shown that
this effect is weak (of the same order as the selection on each gene): the strong
stabilizing selection which is often observed is likely to be caused by correlations
with a limited number of directly selected traits. Possible experiments for distinguishing
the alternatives are discussed.'
acknowledgement: Thanks to JERRY COYNE, BILL HILL, LINDA PARTRIDGE, MICHAEL TURELLI,
and two anonymous reviewers for their critical comments. This work was supported
by grants from the National Science Foundation (BSR-8866548) the Science and Engineering
Research Council (GR/E/08507), and by the Institute of Theoretical Dynamics, University
of California, Davis.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Pleiotropic models of quantitative variation. Genetics. 1990;124(3):773-782.
doi:10.1093/genetics/124.3.773
apa: Barton, N. H. (1990). Pleiotropic models of quantitative variation. Genetics.
Genetics Society of America. https://doi.org/10.1093/genetics/124.3.773
chicago: Barton, Nicholas H. “Pleiotropic Models of Quantitative Variation.” Genetics.
Genetics Society of America, 1990. https://doi.org/10.1093/genetics/124.3.773 .
ieee: N. H. Barton, “Pleiotropic models of quantitative variation,” Genetics,
vol. 124, no. 3. Genetics Society of America, pp. 773–782, 1990.
ista: Barton NH. 1990. Pleiotropic models of quantitative variation. Genetics. 124(3),
773–782.
mla: Barton, Nicholas H. “Pleiotropic Models of Quantitative Variation.” Genetics,
vol. 124, no. 3, Genetics Society of America, 1990, pp. 773–82, doi:10.1093/genetics/124.3.773 .
short: N.H. Barton, Genetics 124 (1990) 773–782.
date_created: 2018-12-11T12:04:26Z
date_published: 1990-03-01T00:00:00Z
date_updated: 2022-02-23T10:41:43Z
day: '01'
doi: '10.1093/genetics/124.3.773 '
extern: '1'
external_id:
pmid:
- '2311921'
intvolume: ' 124'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/124/3/773/5999956?login=true
month: '03'
oa: 1
oa_version: Published Version
page: 773 - 782
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2732'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Pleiotropic models of quantitative variation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 124
year: '1990'
...
---
_id: '4067'
abstract:
- lang: eng
text: This paper proves an O(m 2/3 n 2/3+m+n) upper bound on the number of incidences
between m points and n hyperplanes in four dimensions, assuming all points lie
on one side of each hyperplane and the points and hyperplanes satisfy certain
natural general position conditions. This result has application to various three-dimensional
combinatorial distance problems. For example, it implies the same upper bound
for the number of bichromatic minimum distance pairs in a set of m blue and n
red points in three-dimensional space. This improves the best previous bound for
this problem.
acknowledgement: Research of the first author was supported by the National Science
Foundation under grant CCR-8714565. Work of the second author was supported by Office
of Naval Research Grants DCR-83-20085 and CCR-89-01484, and by grants from the U.S.-Israeli
Binational Science Foundation, the NCRD — the Israeli National Council for Research
and Development, and the Fund for Basic Research in Electronics, Computers and Communication
administered by the Israeli Academy of Sciences.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: 'Edelsbrunner H, Sharir M. A hyperplane Incidence problem with applications
to counting distances. In: Proceedings of the International Symposium on Algorithms.
Vol 450. Springer; 1990:419-428. doi:10.1007/3-540-52921-7_91'
apa: 'Edelsbrunner, H., & Sharir, M. (1990). A hyperplane Incidence problem
with applications to counting distances. In Proceedings of the International
Symposium on Algorithms (Vol. 450, pp. 419–428). Tokyo, Japan: Springer. https://doi.org/10.1007/3-540-52921-7_91'
chicago: Edelsbrunner, Herbert, and Micha Sharir. “A Hyperplane Incidence Problem
with Applications to Counting Distances.” In Proceedings of the International
Symposium on Algorithms, 450:419–28. Springer, 1990. https://doi.org/10.1007/3-540-52921-7_91.
ieee: H. Edelsbrunner and M. Sharir, “A hyperplane Incidence problem with applications
to counting distances,” in Proceedings of the International Symposium on Algorithms,
Tokyo, Japan, 1990, vol. 450, pp. 419–428.
ista: Edelsbrunner H, Sharir M. 1990. A hyperplane Incidence problem with applications
to counting distances. Proceedings of the International Symposium on Algorithms.
SIGAL: Special Interest Group on Algorithms, International Symposium on Algorithms
, LNCS, vol. 450, 419–428.
mla: Edelsbrunner, Herbert, and Micha Sharir. “A Hyperplane Incidence Problem with
Applications to Counting Distances.” Proceedings of the International Symposium
on Algorithms, vol. 450, Springer, 1990, pp. 419–28, doi:10.1007/3-540-52921-7_91.
short: H. Edelsbrunner, M. Sharir, in:, Proceedings of the International Symposium
on Algorithms, Springer, 1990, pp. 419–428.
conference:
end_date: 1990-08-18
location: Tokyo, Japan
name: 'SIGAL: Special Interest Group on Algorithms, International Symposium on
Algorithms '
start_date: 1990-08-16
date_created: 2018-12-11T12:06:45Z
date_published: 1990-01-01T00:00:00Z
date_updated: 2022-02-22T14:31:26Z
day: '01'
doi: 10.1007/3-540-52921-7_91
extern: '1'
intvolume: ' 450'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-52921-7_91
month: '01'
oa_version: None
page: 419 - 428
publication: Proceedings of the International Symposium on Algorithms
publication_identifier:
isbn:
- 978-3-540-52921-7
publication_status: published
publisher: Springer
publist_id: '2056'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A hyperplane Incidence problem with applications to counting distances
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 450
year: '1990'
...
---
_id: '4066'
abstract:
- lang: eng
text: 'We consider several problems involving points and planes in three dimensions.
Our main results are: (i) The maximum number of faces boundingm distinct cells
in an arrangement ofn planes isO(m 2/3 n logn +n 2); we can calculatem such cells
specified by a point in each, in worst-case timeO(m 2/3 n log3 n+n 2 logn). (ii)
The maximum number of incidences betweenn planes andm vertices of their arrangement
isO(m 2/3 n logn+n 2), but this number is onlyO(m 3/5– n 4/5+2 +m+n logm), for
any>0, for any collection of points no three of which are collinear. (iii)
For an arbitrary collection ofm points, we can calculate the number of incidences
between them andn planes by a randomized algorithm whose expected time complexity
isO((m 3/4– n 3/4+3 +m) log2 n+n logn logm) for any>0. (iv) Givenm points andn
planes, we can find the plane lying immediately below each point in randomized
expected timeO([m 3/4– n 3/4+3 +m] log2 n+n logn logm) for any>0. (v) The maximum
number of facets (i.e., (d–1)-dimensional faces) boundingm distinct cells in an
arrangement ofn hyperplanes ind dimensions,d>3, isO(m 2/3 n d/3 logn+n d–1).
This is also an upper bound for the number of incidences betweenn hyperplanes
ind dimensions andm vertices of their arrangement. The combinatorial bounds in
(i) and (v) and the general bound in (ii) are almost tight.'
acknowledgement: "Supported by Amoco Fnd. Fac. Dev. Comput. Sci. 1-6-44862 and by
NSF Grant CCR-8714565. Work on this paper by the first author has been supported
by Amoco Fnd. Fac. Dev. Comput. Sci. I-6-44862 and by NSF Grant CCR-87t4565. Work
by the third author has been supported by Office of Naval Research Grant N00014-87-K-0129,
by National Science Foundation Grant DCR-82-20085, by grants from the Digital Equipment
Corporation, and the IBM Corporation, and by a research grant from the NCRD--the
Israeli National Council for Research and Development. An abstract of this\r\npaper
has appeared in the Proceedings of the 13th International Mathematical Programming
Symposium, Tokyo, 1988, p. 147"
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Edelsbrunner H, Guibas L, Sharir M. The complexity of many cells in arrangements
of planes and related problems. Discrete & Computational Geometry.
1990;5(1):197-216. doi:10.1007/BF02187785
apa: Edelsbrunner, H., Guibas, L., & Sharir, M. (1990). The complexity of many
cells in arrangements of planes and related problems. Discrete & Computational
Geometry. Springer. https://doi.org/10.1007/BF02187785
chicago: Edelsbrunner, Herbert, Leonidas Guibas, and Micha Sharir. “The Complexity
of Many Cells in Arrangements of Planes and Related Problems.” Discrete &
Computational Geometry. Springer, 1990. https://doi.org/10.1007/BF02187785.
ieee: H. Edelsbrunner, L. Guibas, and M. Sharir, “The complexity of many cells in
arrangements of planes and related problems,” Discrete & Computational
Geometry, vol. 5, no. 1. Springer, pp. 197–216, 1990.
ista: Edelsbrunner H, Guibas L, Sharir M. 1990. The complexity of many cells in
arrangements of planes and related problems. Discrete & Computational Geometry.
5(1), 197–216.
mla: Edelsbrunner, Herbert, et al. “The Complexity of Many Cells in Arrangements
of Planes and Related Problems.” Discrete & Computational Geometry,
vol. 5, no. 1, Springer, 1990, pp. 197–216, doi:10.1007/BF02187785.
short: H. Edelsbrunner, L. Guibas, M. Sharir, Discrete & Computational Geometry
5 (1990) 197–216.
date_created: 2018-12-11T12:06:44Z
date_published: 1990-03-01T00:00:00Z
date_updated: 2022-02-22T11:02:41Z
day: '01'
doi: 10.1007/BF02187785
extern: '1'
intvolume: ' 5'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02187785
month: '03'
oa_version: None
page: 197 - 216
publication: Discrete & Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2054'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The complexity of many cells in arrangements of planes and related problems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '1990'
...
---
_id: '4072'
abstract:
- lang: eng
text: We show that the total number of edges ofm faces of an arrangement ofn lines
in the plane isO(m 2/3– n 2/3+2 +n) for any>0. The proof takes an algorithmic
approach, that is, we describe an algorithm for the calculation of thesem faces
and derive the upper bound from the analysis of the algorithm. The algorithm uses
randomization and its expected time complexity isO(m 2/3– n 2/3+2 logn+n logn
logm). If instead of lines we have an arrangement ofn line segments, then the
maximum number of edges ofm faces isO(m 2/3– n 2/3+2 +n (n) logm) for any>0,
where(n) is the functional inverse of Ackermann's function. We give a (randomized)
algorithm that produces these faces and takes expected timeO(m 2/3– n 2/3+2 log+n(n)
log2 n logm).
acknowledgement: The first author is pleased to acknowledge partial support by the
Amoco Fnd. Fac. Dev. Comput. Sci. 1-6-44862 and the National Science Foundation
under Grant CCR-8714565. Work on this paper by the third author has been supported
by Office of Naval Research Grant N00014-82-K-0381, by National Science Foundation
Grant DCR-83-20085, by grants from the Digital Equipment Corporation, and the IBM
Corporation, and by a research grant from the NCRD-the Israeli National Council
for Research and Development. A preliminary version of this paper has appeared in
theProceedings of the 4th ACM Symposium on Computational Geometry, 1988, pp. 44–55.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Edelsbrunner H, Guibas L, Sharir M. The complexity and construction of many
faces in arrangements of lines and of segments. Discrete & Computational
Geometry. 1990;5(1):161-196. doi:10.1007/BF02187784
apa: Edelsbrunner, H., Guibas, L., & Sharir, M. (1990). The complexity and construction
of many faces in arrangements of lines and of segments. Discrete & Computational
Geometry. Springer. https://doi.org/10.1007/BF02187784
chicago: Edelsbrunner, Herbert, Leonidas Guibas, and Micha Sharir. “The Complexity
and Construction of Many Faces in Arrangements of Lines and of Segments.” Discrete
& Computational Geometry. Springer, 1990. https://doi.org/10.1007/BF02187784.
ieee: H. Edelsbrunner, L. Guibas, and M. Sharir, “The complexity and construction
of many faces in arrangements of lines and of segments,” Discrete & Computational
Geometry, vol. 5, no. 1. Springer, pp. 161–196, 1990.
ista: Edelsbrunner H, Guibas L, Sharir M. 1990. The complexity and construction
of many faces in arrangements of lines and of segments. Discrete & Computational
Geometry. 5(1), 161–196.
mla: Edelsbrunner, Herbert, et al. “The Complexity and Construction of Many Faces
in Arrangements of Lines and of Segments.” Discrete & Computational Geometry,
vol. 5, no. 1, Springer, 1990, pp. 161–96, doi:10.1007/BF02187784.
short: H. Edelsbrunner, L. Guibas, M. Sharir, Discrete & Computational Geometry
5 (1990) 161–196.
date_created: 2018-12-11T12:06:46Z
date_published: 1990-01-01T00:00:00Z
date_updated: 2022-02-22T09:27:30Z
day: '01'
doi: 10.1007/BF02187784
extern: '1'
intvolume: ' 5'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02187784
month: '01'
oa_version: None
page: 161 - 196
publication: Discrete & Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2053'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The complexity and construction of many faces in arrangements of lines and
of segments
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '1990'
...