---
_id: '14587'
abstract:
- lang: eng
text: "This thesis concerns the application of variational methods to the study
of evolution problems arising in fluid mechanics and in material sciences. The
main focus is on weak-strong stability properties of some curvature driven interface
evolution problems, such as the two-phase Navier–Stokes flow with surface tension
and multiphase mean curvature flow, and on the phase-field approximation of the
latter. Furthermore, we discuss a variational approach to the study of a class
of doubly nonlinear wave equations.\r\nFirst, we consider the two-phase Navier–Stokes
flow with surface tension within a bounded domain. The two fluids are immiscible
and separated by a sharp interface, which intersects the boundary of the domain
at a constant contact angle of ninety degree. We devise a suitable concept of
varifolds solutions for the associated interface evolution problem and we establish
a weak-strong uniqueness principle in case of a two dimensional ambient space.
In order to focus on the boundary effects and on the singular geometry of the
evolving domains, we work for simplicity in the regime of same viscosities for
the two fluids.\r\nThe core of the thesis consists in the rigorous proof of the
convergence of the vectorial Allen-Cahn equation towards multiphase mean curvature
flow for a suitable class of multi- well potentials and for well-prepared initial
data. We even establish a rate of convergence. Our relative energy approach relies
on the concept of gradient-flow calibration for branching singularities in multiphase
mean curvature flow and thus enables us to overcome the limitations of other approaches.
To the best of the author’s knowledge, our result is the first quantitative and
unconditional one available in the literature for the vectorial/multiphase setting.\r\nThis
thesis also contains a first study of weak-strong stability for planar multiphase
mean curvature flow beyond the singularity resulting from a topology change. Previous
weak-strong results are indeed limited to time horizons before the first topology
change of the strong solution. We consider circular topology changes and we prove
weak-strong stability for BV solutions to planar multiphase mean curvature flow
beyond the associated singular times by dynamically adapting the strong solutions
to the weak one by means of a space-time shift.\r\nIn the context of interface
evolution problems, our proofs for the main results of this thesis are based on
the relative energy technique, relying on novel suitable notions of relative energy
functionals, which in particular measure the interface error. Our statements follow
from the resulting stability estimates for the relative energy associated to the
problem.\r\nAt last, we introduce a variational approach to the study of nonlinear
evolution problems. This approach hinges on the minimization of a parameter dependent
family of convex functionals over entire trajectories, known as Weighted Inertia-Dissipation-Energy
(WIDE) functionals. We consider a class of doubly nonlinear wave equations and
establish the convergence, up to subsequences, of the associated WIDE minimizers
to a solution of the target problem as the parameter goes to zero."
acknowledgement: The research projects contained in this thesis have received funding
from the European Research Council (ERC) under the European Union’s Horizon 2020
research and innovation programme (grant agreement No 948819).
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Alice
full_name: Marveggio, Alice
id: 25647992-AA84-11E9-9D75-8427E6697425
last_name: Marveggio
citation:
ama: Marveggio A. Weak-strong stability and phase-field approximation of interface
evolution problems in fluid mechanics and in material sciences. 2023. doi:10.15479/at:ista:14587
apa: Marveggio, A. (2023). Weak-strong stability and phase-field approximation
of interface evolution problems in fluid mechanics and in material sciences.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14587
chicago: Marveggio, Alice. “Weak-Strong Stability and Phase-Field Approximation
of Interface Evolution Problems in Fluid Mechanics and in Material Sciences.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14587.
ieee: A. Marveggio, “Weak-strong stability and phase-field approximation of interface
evolution problems in fluid mechanics and in material sciences,” Institute of
Science and Technology Austria, 2023.
ista: Marveggio A. 2023. Weak-strong stability and phase-field approximation of
interface evolution problems in fluid mechanics and in material sciences. Institute
of Science and Technology Austria.
mla: Marveggio, Alice. Weak-Strong Stability and Phase-Field Approximation of
Interface Evolution Problems in Fluid Mechanics and in Material Sciences.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14587.
short: A. Marveggio, Weak-Strong Stability and Phase-Field Approximation of Interface
Evolution Problems in Fluid Mechanics and in Material Sciences, Institute of Science
and Technology Austria, 2023.
date_created: 2023-11-21T11:41:05Z
date_published: 2023-11-21T00:00:00Z
date_updated: 2024-03-22T13:21:28Z
day: '21'
ddc:
- '515'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JuFi
doi: 10.15479/at:ista:14587
ec_funded: 1
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date_created: 2023-11-29T09:10:19Z
date_updated: 2024-03-20T12:28:32Z
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file_name: Thesis_Marveggio.zip
file_size: 10189696
relation: source_file
file_date_updated: 2024-03-20T12:28:32Z
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language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '11'
oa: 1
oa_version: Published Version
page: '228'
project:
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
call_identifier: H2020
grant_number: '948819'
name: Bridging Scales in Random Materials
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11842'
relation: part_of_dissertation
status: public
- id: '14597'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
title: Weak-strong stability and phase-field approximation of interface evolution
problems in fluid mechanics and in material sciences
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12491'
abstract:
- lang: eng
text: "The extracellular matrix (ECM) is a hydrated and complex three-dimensional
network consisting of proteins, polysaccharides, and water. It provides structural
scaffolding for the cells embedded within it and is essential in regulating numerous
physiological processes, including cell migration and proliferation, wound healing,
and stem cell fate. \r\nDespite extensive study, detailed structural knowledge
of ECM components in physiologically relevant conditions is still rudimentary.
This is due to methodological limitations in specimen preparation protocols which
are incompatible with keeping large samples, such as the ECM, in their native
state for subsequent imaging. Conventional electron microscopy (EM) techniques
rely on fixation, dehydration, contrasting, and sectioning. This results in the
alteration of a highly hydrated environment and the potential introduction of
artifacts. Other structural biology techniques, such as nuclear magnetic resonance
(NMR) spectroscopy and X-ray crystallography, allow high-resolution analysis of
protein structures but only work on homogenous and purified samples, hence lacking
contextual information. Currently, no approach exists for the ultrastructural
and structural study of extracellular components under native conditions in a
physiological, 3D environment. \r\nIn this thesis, I have developed a workflow
that allows for the ultrastructural analysis of the ECM in near-native conditions
at molecular resolution. The developments I introduced include implementing a
novel specimen preparation workflow for cell-derived matrices (CDMs) to render
them compatible with ion-beam milling and subsequent high-resolution cryo-electron
tomography (ET). \r\nTo this end, I have established protocols to generate CDMs
grown over several weeks on EM grids that are compatible with downstream cryo-EM
sample preparation and imaging techniques. Characterization of these ECMs confirmed
that they contain essential ECM components such as collagen I, collagen VI, and
fibronectin I in high abundance and hence represent a bona fide biologically-relevant
sample. I successfully optimized vitrification of these specimens by testing various
vitrification techniques and cryoprotectants. \r\nIn order to obtain high-resolution
molecular insights into the ultrastructure and organization of CDMs, I established
cryo-focused ion beam scanning electron microscopy (FIBSEM) on these challenging
and complex specimens. I explored different approaches for the creation of thin
cryo-lamellae by FIB milling and succeeded in optimizing the cryo-lift-out technique,
resulting in high-quality lamellae of approximately 200 nm thickness. \r\nHigh-resolution
Cryo-ET of these lamellae revealed for the first time the architecture of native
CDM in the context of matrix-secreting cells. This allowed for the in situ visualization
of fibrillar matrix proteins such as collagen, laying the foundation for future
structural and ultrastructural characterization of these proteins in their near-native
environment. \r\nIn summary, in this thesis, I present a novel workflow that combines
state-of-the-art cryo-EM specimen preparation and imaging technologies to permit
characterization of the ECM, an important tissue component in higher organisms.
This innovative and highly versatile workflow will enable addressing far-reaching
questions on ECM architecture, composition, and reciprocal ECM-cell interactions."
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
citation:
ama: Zens B. Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography. 2023. doi:10.15479/at:ista:12491
apa: Zens, B. (2023). Ultrastructural characterization of natively preserved
extracellular matrix by cryo-electron tomography. Institute of Science and
Technology Austria. https://doi.org/10.15479/at:ista:12491
chicago: Zens, Bettina. “Ultrastructural Characterization of Natively Preserved
Extracellular Matrix by Cryo-Electron Tomography.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:12491.
ieee: B. Zens, “Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography,” Institute of Science and Technology Austria,
2023.
ista: Zens B. 2023. Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography. Institute of Science and Technology Austria.
mla: Zens, Bettina. Ultrastructural Characterization of Natively Preserved Extracellular
Matrix by Cryo-Electron Tomography. Institute of Science and Technology Austria,
2023, doi:10.15479/at:ista:12491.
short: B. Zens, Ultrastructural Characterization of Natively Preserved Extracellular
Matrix by Cryo-Electron Tomography, Institute of Science and Technology Austria,
2023.
date_created: 2023-02-02T14:50:20Z
date_published: 2023-02-02T00:00:00Z
date_updated: 2024-03-25T23:30:05Z
day: '02'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: FlSc
doi: 10.15479/at:ista:12491
file:
- access_level: open_access
checksum: 069d87f025e0799bf9e3c375664264f2
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creator: bzens
date_created: 2023-02-07T13:07:38Z
date_updated: 2024-02-08T23:30:04Z
embargo: 2024-02-07
file_id: '12527'
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file_size: 23082464
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creator: bzens
date_created: 2023-02-07T13:09:05Z
date_updated: 2024-02-08T23:30:04Z
embargo_to: open_access
file_id: '12528'
file_name: PhDThesis_BettinaZens_2023_final.docx
file_size: 106169509
relation: source_file
file_date_updated: 2024-02-08T23:30:04Z
has_accepted_license: '1'
keyword:
- cryo-EM
- cryo-ET
- FIB milling
- method development
- FIBSEM
- extracellular matrix
- ECM
- cell-derived matrices
- CDMs
- cell culture
- high pressure freezing
- HPF
- structural biology
- tomography
- collagen
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '187'
project:
- _id: eba3b5f6-77a9-11ec-83b8-cf0905748aa3
name: Integrated visual proteomics of reciprocal cell-extracellular matrix interactions
- _id: 059B463C-7A3F-11EA-A408-12923DDC885E
name: NÖ-Fonds Preis für die Jungforscherin des Jahres am IST Austria
publication_identifier:
isbn:
- 978-3-99078-027-5
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8586'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
title: Ultrastructural characterization of natively preserved extracellular matrix
by cryo-electron tomography
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14226'
abstract:
- lang: eng
text: "We introduce the notion of a Faustian interchange in a 1-parameter family
of smooth\r\nfunctions to generalize the medial axis to critical points of index
larger than 0.\r\nWe construct and implement a general purpose algorithm for approximating
such\r\ngeneralized medial axes."
alternative_title:
- ISTA Master's Thesis
article_processing_charge: No
author:
- first_name: Elizabeth R
full_name: Stephenson, Elizabeth R
id: 2D04F932-F248-11E8-B48F-1D18A9856A87
last_name: Stephenson
orcid: 0000-0002-6862-208X
citation:
ama: Stephenson ER. Generalizing medial axes with homology switches. 2023. doi:10.15479/at:ista:14226
apa: Stephenson, E. R. (2023). Generalizing medial axes with homology switches.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14226
chicago: Stephenson, Elizabeth R. “Generalizing Medial Axes with Homology Switches.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14226.
ieee: E. R. Stephenson, “Generalizing medial axes with homology switches,” Institute
of Science and Technology Austria, 2023.
ista: Stephenson ER. 2023. Generalizing medial axes with homology switches. Institute
of Science and Technology Austria.
mla: Stephenson, Elizabeth R. Generalizing Medial Axes with Homology Switches.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14226.
short: E.R. Stephenson, Generalizing Medial Axes with Homology Switches, Institute
of Science and Technology Austria, 2023.
date_created: 2023-08-24T13:01:18Z
date_published: 2023-08-24T00:00:00Z
date_updated: 2024-02-26T23:30:04Z
day: '24'
ddc:
- '500'
degree_awarded: MS
department:
- _id: GradSch
- _id: HeEd
doi: 10.15479/at:ista:14226
file:
- access_level: closed
checksum: 453caf851d75c3478c10ed09bd242a91
content_type: application/x-zip-compressed
creator: cchlebak
date_created: 2023-08-24T13:02:49Z
date_updated: 2024-02-26T23:30:03Z
embargo_to: open_access
file_id: '14227'
file_name: documents-export-2023-08-24.zip
file_size: 15501411
relation: source_file
- access_level: open_access
checksum: 7349d29963d6695e555e171748648d9a
content_type: application/pdf
creator: cchlebak
date_created: 2023-08-24T13:03:42Z
date_updated: 2024-02-26T23:30:03Z
embargo: 2024-02-25
file_id: '14228'
file_name: thesis_pdf_a.pdf
file_size: 6854783
relation: main_file
file_date_updated: 2024-02-26T23:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '43'
publication_identifier:
issn:
- 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
title: Generalizing medial axes with homology switches
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12470'
abstract:
- lang: eng
text: "The brain is an exceptionally sophisticated organ consisting of billions
of cells and trillions of \r\nconnections that orchestrate our cognition and behavior.
To decode its complex connectivity, it is \r\npivotal to disentangle its intricate
architecture spanning from cm-sized circuits down to tens of \r\nnm-small synapses.\r\nTo
achieve this goal, I developed CATS – Comprehensive Analysis of nervous Tissue
across \r\nScales, a versatile toolbox for obtaining a holistic view of nervous
tissue context with (super\x02resolution) fluorescence microscopy. CATS combines
comprehensive labeling of the extracellular\r\nspace, that is compatible with
chemical fixation, with information on molecular markers, super\x02resolved data
acquisition and machine-learning based data analysis for segmentation and synapse
\r\nidentification.\r\nI used CATS to analyze key features of nervous tissue connectivity,
ranging from whole tissue \r\narchitecture, neuronal in- and output-fields, down
to synapse morphology.\r\nFocusing on the hippocampal circuitry, I quantified
synaptic transmission properties of mossy \r\nfiber boutons and analyzed the connectivity
pattern of dentate gyrus granule cells with CA3 \r\npyramidal neurons. This shows
that CATS is a viable tool to study hallmarks of neuronal \r\nconnectivity with
light microscopy."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
- _id: EM-Fac
- _id: M-Shop
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Julia M
full_name: Michalska, Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
orcid: 0000-0003-3862-1235
citation:
ama: Michalska JM. A versatile toolbox for the comprehensive analysis of nervous
tissue organization with light microscopy. 2023. doi:10.15479/at:ista:12470
apa: Michalska, J. M. (2023). A versatile toolbox for the comprehensive analysis
of nervous tissue organization with light microscopy. Institute of Science
and Technology Austria. https://doi.org/10.15479/at:ista:12470
chicago: Michalska, Julia M. “A Versatile Toolbox for the Comprehensive Analysis
of Nervous Tissue Organization with Light Microscopy.” Institute of Science and
Technology Austria, 2023. https://doi.org/10.15479/at:ista:12470.
ieee: J. M. Michalska, “A versatile toolbox for the comprehensive analysis of nervous
tissue organization with light microscopy,” Institute of Science and Technology
Austria, 2023.
ista: Michalska JM. 2023. A versatile toolbox for the comprehensive analysis of
nervous tissue organization with light microscopy. Institute of Science and Technology
Austria.
mla: Michalska, Julia M. A Versatile Toolbox for the Comprehensive Analysis of
Nervous Tissue Organization with Light Microscopy. Institute of Science and
Technology Austria, 2023, doi:10.15479/at:ista:12470.
short: J.M. Michalska, A Versatile Toolbox for the Comprehensive Analysis of Nervous
Tissue Organization with Light Microscopy, Institute of Science and Technology
Austria, 2023.
date_created: 2023-01-31T15:10:53Z
date_published: 2023-01-09T00:00:00Z
date_updated: 2023-08-31T12:26:58Z
day: '09'
ddc:
- '610'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoDa
doi: 10.15479/at:ista:12470
ec_funded: 1
file:
- access_level: open_access
checksum: 1a2306e5f59f52df598e7ecfadf921ac
content_type: application/pdf
creator: cchlebak
date_created: 2023-01-31T15:11:42Z
date_updated: 2023-07-27T22:30:54Z
embargo: 2023-07-09
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file_size: 41771714
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creator: cchlebak
date_created: 2023-01-31T15:11:51Z
date_updated: 2023-07-10T22:30:04Z
embargo_to: open_access
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file_size: 66983464
relation: source_file
file_date_updated: 2023-07-27T22:30:54Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: '201'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 26AA4EF2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication_identifier:
isbn:
- ' 978-3-99078-026-8'
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11943'
relation: part_of_dissertation
status: public
- id: '11950'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
title: A versatile toolbox for the comprehensive analysis of nervous tissue organization
with light microscopy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12531'
abstract:
- lang: eng
text: "All visual experiences of the vertebrates begin with light being converted
into electrical signals\r\nby the eye retina. Retinal ganglion cells (RGCs) are
the neurons of the innermost layer of the\r\nmammal retina, and they transmit
visual information to the rest of the brain.\r\nIt has been shown that RGCs vary
in their morphology and genetic profiles, moreover they can\r\nbe unambiguously
grouped into subtypes that share the same morphological and/or molecular\r\nproperties.
However, in terms of RGCs function, it remains unclear how many distinct types\r\nthere
are and what response properties their typology relies on. Even given the recent
studies\r\nthat successfully classified RGCs in a patch of the retina [1] and
in scotopic conditions [2], the\r\nquestion remains whether the found subtypes
persist across the entire retina.\r\nIn this work, using a novel imaging method,
we show that, when sampled from a large portion\r\nof the retina, RGCs can not
be clearly divided into functional subtypes. We found that in\r\nphotopic conditions,
which implies more prominent natural scene statistic differences across\r\nthe
visual field, response properties can be exhibited by cells differently depending
on their\r\nlocation in the retina, which leads to formation of a gradient of
features rather than distinct\r\nclasses.\r\nThis finding suggests that RGCs follow
a global organization across the visual field of the\r\nanimal, adapting each
RGC subtype to the requirements imposed by the natural scene statistics."
alternative_title:
- ISTA Master's Thesis
article_processing_charge: No
author:
- first_name: Kseniia
full_name: Kirillova, Kseniia
id: 8e3f931e-dc85-11ea-9058-e7b957bf23f0
last_name: Kirillova
citation:
ama: Kirillova K. Panoramic functional gradients across the mouse retina. 2023.
doi:10.15479/at:ista:12531
apa: Kirillova, K. (2023). Panoramic functional gradients across the mouse retina.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12531
chicago: Kirillova, Kseniia. “Panoramic Functional Gradients across the Mouse Retina.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12531.
ieee: K. Kirillova, “Panoramic functional gradients across the mouse retina,” Institute
of Science and Technology Austria, 2023.
ista: Kirillova K. 2023. Panoramic functional gradients across the mouse retina.
Institute of Science and Technology Austria.
mla: Kirillova, Kseniia. Panoramic Functional Gradients across the Mouse Retina.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12531.
short: K. Kirillova, Panoramic Functional Gradients across the Mouse Retina, Institute
of Science and Technology Austria, 2023.
date_created: 2023-02-09T07:45:05Z
date_published: 2023-02-08T00:00:00Z
date_updated: 2024-02-09T23:30:04Z
day: '08'
ddc:
- '570'
degree_awarded: MS
department:
- _id: GradSch
- _id: MaJö
doi: 10.15479/at:ista:12531
file:
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checksum: 57d8da3a6c749eb1556b7435fe266a5f
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creator: cchlebak
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file_size: 11204408
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file_date_updated: 2024-02-09T23:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '46'
publication_identifier:
issn:
- 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
title: Panoramic functional gradients across the mouse retina
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2023'
...
---
_id: '12800'
abstract:
- lang: eng
text: 'The evolutionary processes that brought about today’s plethora of living
species and the many billions more ancient ones all underlie biology. Evolutionary
pathways are neither directed nor deterministic, but rather an interplay between
selection, migration, mutation, genetic drift and other environmental factors.
Hybrid zones, as natural crossing experiments, offer a great opportunity to use
cline analysis to deduce different evolutionary processes - for example, selection
strength. Theoretical cline models, largely assuming uniform distribution of individuals,
often lack the capability of incorporating population structure. Since in reality
organisms mostly live in patchy distributions and their dispersal is hardly ever
Gaussian, it is necessary to unravel the effect of these different elements of
population structure on cline parameters and shape. In this thesis, I develop
a simulation inspired by the A. majus hybrid zone of a single selected locus under
frequency dependent selection. This simulation enables us to untangle the effects
of different elements of population structure as for example a low-density center
and long-range dispersal. This thesis is therefore a first step towards theoretically
untangling the effects of different elements of population structure on cline
parameters and shape. '
alternative_title:
- ISTA Master's Thesis
article_processing_charge: No
author:
- first_name: Mara
full_name: Julseth, Mara
id: 1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
last_name: Julseth
citation:
ama: Julseth M. The effect of local population structure on genetic variation at
selected loci in the A. majus hybrid zone. 2023. doi:10.15479/at:ista:12800
apa: Julseth, M. (2023). The effect of local population structure on genetic
variation at selected loci in the A. majus hybrid zone. Institute of Science
and Technology Austria. https://doi.org/10.15479/at:ista:12800
chicago: Julseth, Mara. “The Effect of Local Population Structure on Genetic Variation
at Selected Loci in the A. Majus Hybrid Zone.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:12800.
ieee: M. Julseth, “The effect of local population structure on genetic variation
at selected loci in the A. majus hybrid zone,” Institute of Science and Technology
Austria, 2023.
ista: Julseth M. 2023. The effect of local population structure on genetic variation
at selected loci in the A. majus hybrid zone. Institute of Science and Technology
Austria.
mla: Julseth, Mara. The Effect of Local Population Structure on Genetic Variation
at Selected Loci in the A. Majus Hybrid Zone. Institute of Science and Technology
Austria, 2023, doi:10.15479/at:ista:12800.
short: M. Julseth, The Effect of Local Population Structure on Genetic Variation
at Selected Loci in the A. Majus Hybrid Zone, Institute of Science and Technology
Austria, 2023.
date_created: 2023-04-04T18:57:11Z
date_published: 2023-04-05T00:00:00Z
date_updated: 2023-06-02T22:30:05Z
day: '05'
ddc:
- '576'
degree_awarded: MS
department:
- _id: GradSch
- _id: NiBa
doi: 10.15479/at:ista:12800
file:
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date_created: 2023-04-06T06:11:27Z
date_updated: 2023-06-02T22:30:04Z
embargo: 2023-06-01
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creator: mjulseth
date_created: 2023-04-06T08:26:37Z
date_updated: 2023-06-02T22:30:04Z
embargo: 2023-06-01
file_id: '12813'
file_name: ThesisMaraJulseth_04_23.pdf
file_size: 1741364
relation: main_file
file_date_updated: 2023-06-02T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '21'
publication_identifier:
issn:
- 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: The effect of local population structure on genetic variation at selected loci
in the A. majus hybrid zone
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14510'
acknowledged_ssus:
- _id: EM-Fac
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Nataliia
full_name: Gnyliukh, Nataliia
id: 390C1120-F248-11E8-B48F-1D18A9856A87
last_name: Gnyliukh
orcid: 0000-0002-2198-0509
citation:
ama: Gnyliukh N. Mechanism of clathrin-coated vesicle formation during endocytosis
in plants. 2023. doi:10.15479/at:ista:14510
apa: Gnyliukh, N. (2023). Mechanism of clathrin-coated vesicle formation during
endocytosis in plants. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14510
chicago: Gnyliukh, Nataliia. “Mechanism of Clathrin-Coated Vesicle Formation during
Endocytosis in Plants.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14510.
ieee: N. Gnyliukh, “Mechanism of clathrin-coated vesicle formation during endocytosis
in plants,” Institute of Science and Technology Austria, 2023.
ista: Gnyliukh N. 2023. Mechanism of clathrin-coated vesicle formation during endocytosis
in plants. Institute of Science and Technology Austria.
mla: Gnyliukh, Nataliia. Mechanism of Clathrin-Coated Vesicle Formation during
Endocytosis in Plants. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:14510.
short: N. Gnyliukh, Mechanism of Clathrin-Coated Vesicle Formation during Endocytosis
in Plants, Institute of Science and Technology Austria, 2023.
date_created: 2023-11-10T09:10:06Z
date_published: 2023-11-10T00:00:00Z
date_updated: 2024-03-27T23:30:45Z
day: '10'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JiFr
- _id: MaLo
doi: 10.15479/at:ista:14510
ec_funded: 1
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creator: ngnyliuk
date_created: 2023-11-20T09:18:51Z
date_updated: 2023-11-20T09:18:51Z
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file_size: 20824903
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content_type: application/pdf
creator: ngnyliuk
date_created: 2023-11-20T09:23:11Z
date_updated: 2023-11-23T13:10:55Z
embargo: 2024-11-23
embargo_to: open_access
file_id: '14568'
file_name: Thesis_Gnyliukh_final_20_11_23.pdf
file_size: 24871844
relation: main_file
file_date_updated: 2023-11-23T13:10:55Z
has_accepted_license: '1'
keyword:
- Clathrin-Mediated Endocytosis
- vesicle scission
- Dynamin-Related Protein 2
- SH3P2
- TPLATE complex
- Total internal reflection fluorescence microscopy
- Arabidopsis thaliana
language:
- iso: eng
month: '11'
oa_version: Published Version
page: '180'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-037-4
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '14591'
relation: part_of_dissertation
status: public
- id: '9887'
relation: part_of_dissertation
status: public
- id: '8139'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
title: Mechanism of clathrin-coated vesicle formation during endocytosis in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12897'
abstract:
- lang: eng
text: "Inverse design problems in fabrication-aware shape optimization are typically
solved on discrete representations such as polygonal meshes. This thesis argues
that there are benefits to treating these problems in the same domain as human
designers, namely, the parametric one. One reason is that discretizing a parametric
model usually removes the capability of making further manual changes to the design,
because the human intent is captured by the shape parameters. Beyond this, knowledge
about a design problem can sometimes reveal a structure that is present in a smooth
representation, but is fundamentally altered by discretizing. In this case, working
in the parametric domain may even simplify the optimization task. We present two
lines of research that explore both of these aspects of fabrication-aware shape
optimization on parametric representations.\r\n\r\nThe first project studies the
design of plane elastic curves and Kirchhoff rods, which are common mathematical
models for describing the deformation of thin elastic rods such as beams, ribbons,
cables, and hair. Our main contribution is a characterization of all curved shapes
that can be attained by bending and twisting elastic rods having a stiffness that
is allowed to vary across the length. Elements like these can be manufactured
using digital fabrication devices such as 3d printers and digital cutters, and
have applications in free-form architecture and soft robotics.\r\n\r\nWe show
that the family of curved shapes that can be produced this way admits geometric
description that is concise and computationally convenient. In the case of plane
curves, the geometric description is intuitive enough to allow a designer to determine
whether a curved shape is physically achievable by visual inspection alone. We
also present shape optimization algorithms that convert a user-defined curve in
the plane or in three dimensions into the geometry of an elastic rod that will
naturally deform to follow this curve when its endpoints are attached to a support
structure. Implemented in an interactive software design tool, the rod geometry
is generated in real time as the user edits a curve and enables fast prototyping.
\r\n\r\nThe second project tackles the problem of general-purpose shape optimization
on CAD models using a novel variant of the extended finite element method (XFEM).
Our goal is the decoupling between the simulation mesh and the CAD model, so no
geometry-dependent meshing or remeshing needs to be performed when the CAD parameters
change during optimization. This is achieved by discretizing the embedding space
of the CAD model, and using a new high-accuracy numerical integration method to
enable XFEM on free-form elements bounded by the parametric surface patches of
the model. Our simulation is differentiable from the CAD parameters to the simulation
output, which enables us to use off-the-shelf gradient-based optimization procedures.
The result is a method that fits seamlessly into the CAD workflow because it works
on the same representation as the designer, enabling the alternation of manual
editing and fabrication-aware optimization at will."
acknowledged_ssus:
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Christian
full_name: Hafner, Christian
id: 400429CC-F248-11E8-B48F-1D18A9856A87
last_name: Hafner
citation:
ama: 'Hafner C. Inverse shape design with parametric representations: Kirchhoff
Rods and parametric surface models. 2023. doi:10.15479/at:ista:12897'
apa: 'Hafner, C. (2023). Inverse shape design with parametric representations:
Kirchhoff Rods and parametric surface models. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:12897'
chicago: 'Hafner, Christian. “Inverse Shape Design with Parametric Representations:
Kirchhoff Rods and Parametric Surface Models.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:12897.'
ieee: 'C. Hafner, “Inverse shape design with parametric representations: Kirchhoff
Rods and parametric surface models,” Institute of Science and Technology Austria,
2023.'
ista: 'Hafner C. 2023. Inverse shape design with parametric representations: Kirchhoff
Rods and parametric surface models. Institute of Science and Technology Austria.'
mla: 'Hafner, Christian. Inverse Shape Design with Parametric Representations:
Kirchhoff Rods and Parametric Surface Models. Institute of Science and Technology
Austria, 2023, doi:10.15479/at:ista:12897.'
short: 'C. Hafner, Inverse Shape Design with Parametric Representations: Kirchhoff
Rods and Parametric Surface Models, Institute of Science and Technology Austria,
2023.'
date_created: 2023-05-05T10:40:14Z
date_published: 2023-05-05T00:00:00Z
date_updated: 2024-01-29T10:47:51Z
day: '05'
ddc:
- '516'
- '004'
- '518'
- '531'
degree_awarded: PhD
department:
- _id: GradSch
- _id: BeBi
doi: 10.15479/at:ista:12897
ec_funded: 1
file:
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creator: chafner
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date_updated: 2023-12-08T23:30:04Z
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date_updated: 2023-12-08T23:30:04Z
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file_size: 265319
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language:
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month: '05'
oa: 1
oa_version: Published Version
page: '180'
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication_identifier:
isbn:
- 978-3-99078-031-2
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: part_of_dissertation
status: public
- id: '7117'
relation: part_of_dissertation
status: public
- id: '13188'
relation: dissertation_contains
status: public
status: public
supervisor:
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
title: 'Inverse shape design with parametric representations: Kirchhoff Rods and parametric
surface models'
type: dissertation
user_id: 400429CC-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12072'
abstract:
- lang: eng
text: "In this thesis, we study two of the most important questions in Arithmetic
geometry: that of the existence and density of solutions to Diophantine equations.
In order for a Diophantine equation to have any solutions over the rational numbers,
it must have solutions everywhere locally, i.e., over R and over Qp for every
prime p. The converse, called the Hasse principle, is known to fail in general.
However, it is still a central question in Arithmetic geometry to determine for
which varieties the Hasse principle does hold. In this work, we establish the
Hasse principle for a wide new family of varieties of the form f(t) = NK/Q(x)
̸= 0, where f is a polynomial with integer coefficients and NK/Q denotes the norm\r\nform
associated to a number field K. Our results cover products of arbitrarily many
linear, quadratic or cubic factors, and generalise an argument of Irving [69],
which makes use of the beta sieve of Rosser and Iwaniec. We also demonstrate how
our main sieve results can be applied to treat new cases of a conjecture of Harpaz
and Wittenberg on locally split values of polynomials over number fields, and
discuss consequences for rational points in fibrations.\r\nIn the second question,
about the density of solutions, one defines a height function and seeks to estimate
asymptotically the number of points of height bounded by B as B → ∞. Traditionally,
one either counts rational points, or\r\nintegral points with respect to a suitable
model. However, in this thesis, we study an emerging area of interest in Arithmetic
geometry known as Campana points, which in some sense interpolate between rational
and integral points.\r\nMore precisely, we count the number of nonzero integers
z1, z2, z3 such that gcd(z1, z2, z3) = 1, and z1, z2, z3, z1 + z2 + z3 are all
squareful and bounded by B. Using the circle method, we obtain an asymptotic formula
which agrees in\r\nthe power of B and log B with a bold new generalisation of
Manin’s conjecture to the setting of Campana points, recently formulated by Pieropan,
Smeets, Tanimoto and Várilly-Alvarado [96]. However, in this thesis we also provide
the first known counterexamples to leading constant predicted by their conjecture. "
acknowledgement: I acknowledge the received funding from the European Union’s Horizon
2020 research and innovation programme under the Marie Sklodowska Curie Grant Agreement
No. 665385.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Alec L
full_name: Shute, Alec L
id: 440EB050-F248-11E8-B48F-1D18A9856A87
last_name: Shute
orcid: 0000-0002-1812-2810
citation:
ama: 'Shute AL. Existence and density problems in Diophantine geometry: From norm
forms to Campana points. 2022. doi:10.15479/at:ista:12072'
apa: 'Shute, A. L. (2022). Existence and density problems in Diophantine geometry:
From norm forms to Campana points. Institute of Science and Technology Austria.
https://doi.org/10.15479/at:ista:12072'
chicago: 'Shute, Alec L. “Existence and Density Problems in Diophantine Geometry:
From Norm Forms to Campana Points.” Institute of Science and Technology Austria,
2022. https://doi.org/10.15479/at:ista:12072.'
ieee: 'A. L. Shute, “Existence and density problems in Diophantine geometry: From
norm forms to Campana points,” Institute of Science and Technology Austria, 2022.'
ista: 'Shute AL. 2022. Existence and density problems in Diophantine geometry: From
norm forms to Campana points. Institute of Science and Technology Austria.'
mla: 'Shute, Alec L. Existence and Density Problems in Diophantine Geometry:
From Norm Forms to Campana Points. Institute of Science and Technology Austria,
2022, doi:10.15479/at:ista:12072.'
short: 'A.L. Shute, Existence and Density Problems in Diophantine Geometry: From
Norm Forms to Campana Points, Institute of Science and Technology Austria, 2022.'
date_created: 2022-09-08T21:53:03Z
date_published: 2022-09-08T00:00:00Z
date_updated: 2023-02-21T16:37:35Z
day: '08'
ddc:
- '512'
degree_awarded: PhD
department:
- _id: GradSch
- _id: TiBr
doi: 10.15479/at:ista:12072
ec_funded: 1
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oa: 1
oa_version: Published Version
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call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-023-7
issn:
- 2663-337X
publication_status: published
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supervisor:
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full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
title: 'Existence and density problems in Diophantine geometry: From norm forms to
Campana points'
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11777'
abstract:
- lang: eng
text: "In this dissertation we study coboundary expansion of simplicial complex
with a view of giving geometric applications.\r\nOur main novel tool is an equivariant
version of Gromov's celebrated Topological Overlap Theorem. The equivariant topological
overlap theorem leads to various geometric applications including a quantitative
non-embeddability result for sufficiently thick buildings (which partially resolves
a conjecture of Tancer and Vorwerk) and an improved lower bound on the pair-crossing
number of (bounded degree) expander graphs. Additionally, we will give new proofs
for several known lower bounds for geometric problems such as the number of Tverberg
partitions or the crossing number of complete bipartite graphs.\r\nFor the aforementioned
applications one is naturally lead to study expansion properties of joins of simplicial
complexes. In the presence of a special certificate for expansion (as it is the
case, e.g., for spherical buildings), the join of two expanders is an expander.
On the flip-side, we report quite some evidence that coboundary expansion exhibits
very non-product-like behaviour under taking joins. For instance, we exhibit infinite
families of graphs $(G_n)_{n\\in \\mathbb{N}}$ and $(H_n)_{n\\in\\mathbb{N}}$
whose join $G_n*H_n$ has expansion of lower order than the product of the expansion
constant of the graphs. Moreover, we show an upper bound of $(d+1)/2^d$ on the
normalized coboundary expansion constants for the complete multipartite complex
$[n]^{*(d+1)}$ (under a mild divisibility condition on $n$).\r\nVia the probabilistic
method the latter result extends to an upper bound of $(d+1)/2^d+\\varepsilon$
on the coboundary expansion constant of the spherical building associated with
$\\mathrm{PGL}_{d+2}(\\mathbb{F}_q)$ for any $\\varepsilon>0$ and sufficiently
large $q=q(\\varepsilon)$. This disproves a conjecture of Lubotzky, Meshulam and
Mozes -- in a rather strong sense.\r\nBy improving on existing lower bounds we
make further progress towards closing the gap between the known lower and upper
bounds on the coboundary expansion constants of $[n]^{*(d+1)}$. The best improvements
we achieve using computer-aided proofs and flag algebras. The exact value even
for the complete $3$-partite $2$-dimensional complex $[n]^{*3}$ remains unknown
but we are happy to conjecture a precise value for every $n$. %Moreover, we show
that a previously shown lower bound on the expansion constant of the spherical
building associated with $\\mathrm{PGL}_{2}(\\mathbb{F}_q)$ is not tight.\r\nIn
a loosely structured, last chapter of this thesis we collect further smaller observations
related to expansion. We point out a link between discrete Morse theory and a
technique for showing coboundary expansion, elaborate a bit on the hardness of
computing coboundary expansion constants, propose a new criterion for coboundary
expansion (in a very dense setting) and give one way of making the folklore result
that expansion of links is a necessary condition for a simplicial complex to be
an expander precise."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Pascal
full_name: Wild, Pascal
id: 4C20D868-F248-11E8-B48F-1D18A9856A87
last_name: Wild
citation:
ama: Wild P. High-dimensional expansion and crossing numbers of simplicial complexes.
2022. doi:10.15479/at:ista:11777
apa: Wild, P. (2022). High-dimensional expansion and crossing numbers of simplicial
complexes. Institute of Science and Technology. https://doi.org/10.15479/at:ista:11777
chicago: Wild, Pascal. “High-Dimensional Expansion and Crossing Numbers of Simplicial
Complexes.” Institute of Science and Technology, 2022. https://doi.org/10.15479/at:ista:11777.
ieee: P. Wild, “High-dimensional expansion and crossing numbers of simplicial complexes,”
Institute of Science and Technology, 2022.
ista: Wild P. 2022. High-dimensional expansion and crossing numbers of simplicial
complexes. Institute of Science and Technology.
mla: Wild, Pascal. High-Dimensional Expansion and Crossing Numbers of Simplicial
Complexes. Institute of Science and Technology, 2022, doi:10.15479/at:ista:11777.
short: P. Wild, High-Dimensional Expansion and Crossing Numbers of Simplicial Complexes,
Institute of Science and Technology, 2022.
date_created: 2022-08-10T15:51:19Z
date_published: 2022-08-11T00:00:00Z
date_updated: 2023-06-22T09:56:36Z
day: '11'
ddc:
- '500'
- '516'
- '514'
degree_awarded: PhD
department:
- _id: GradSch
- _id: UlWa
doi: 10.15479/at:ista:11777
ec_funded: 1
file:
- access_level: open_access
checksum: f5f3af1fb7c8a24b71ddc88ad7f7c5b4
content_type: text/x-python
creator: pwild
date_created: 2022-08-10T15:34:04Z
date_updated: 2022-08-10T15:34:04Z
description: Code for computer-assisted proofs in Section 8.4.7 in Thesis
file_id: '11780'
file_name: flags.py
file_size: 16828
relation: supplementary_material
- access_level: open_access
checksum: 1f7c12dfe3bdaa9b147e4fbc3d34e3d5
content_type: text/x-c++src
creator: pwild
date_created: 2022-08-10T15:34:10Z
date_updated: 2022-08-10T15:34:10Z
description: Code for proof of Lemma 8.20 in Thesis
file_id: '11781'
file_name: lowerbound.cpp
file_size: 12226
relation: supplementary_material
- access_level: open_access
checksum: 4cf81455c49e5dec3b9b2e3980137eeb
content_type: text/x-python
creator: pwild
date_created: 2022-08-10T15:34:17Z
date_updated: 2022-08-10T15:34:17Z
description: Code for proof of Proposition 7.9 in Thesis
file_id: '11782'
file_name: upperbound.py
file_size: 3240
relation: supplementary_material
- access_level: open_access
checksum: 4e96575b10cbe4e0d0db2045b2847774
content_type: application/pdf
creator: pwild
date_created: 2022-08-11T16:08:33Z
date_updated: 2022-08-11T16:08:33Z
file_id: '11809'
file_name: finalthesisPascalWildPDFA.pdf
file_size: 5086282
relation: main_file
title: High-Dimensional Expansion and Crossing Numbers of Simplicial Complexes
- access_level: closed
checksum: 92d94842a1fb6dca5808448137573b2e
content_type: application/zip
creator: pwild
date_created: 2022-08-11T16:09:19Z
date_updated: 2022-08-11T16:09:19Z
file_id: '11810'
file_name: ThesisSubmission.zip
file_size: 18150068
relation: source_file
file_date_updated: 2022-08-11T16:09:19Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '170'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-021-3
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology
status: public
supervisor:
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
title: High-dimensional expansion and crossing numbers of simplicial complexes
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '11128'
abstract:
- lang: eng
text: "Although we often see studies focusing on simple or even discrete traits
in studies of colouration,\r\nthe variation of “appearance” phenotypes found in
nature is often more complex, continuous\r\nand high-dimensional. Therefore, we
developed automated methods suitable for large datasets\r\nof genomes and images,
striving to account for their complex nature, while minimising human\r\nbias.
We used these methods on a dataset of more than 20, 000 plant SNP genomes and\r\ncorresponding
fower images from a hybrid zone of two subspecies of Antirrhinum majus with\r\ndistinctly
coloured fowers to improve our understanding of the genetic nature of the fower\r\ncolour
in our study system.\r\nFirstly, we use the advantage of large numbers of genotyped
plants to estimate the haplotypes in\r\nthe main fower colour regulating region.
We study colour- and geography-related characteristics\r\nof the estimated haplotypes
and how they connect to their relatedness. We show discrepancies\r\nfrom the expected
fower colour distributions given the genotype and identify particular\r\nhaplotypes
leading to unexpected phenotypes. We also confrm a signifcant defcit of the\r\ndouble
recessive recombinant and quite surprisingly, we show that haplotypes of the most\r\nfrequent
parental type are much less variable than others.\r\nSecondly, we introduce our
pipeline capable of processing tens of thousands of full fower\r\nimages without
human interaction and summarising each image into a set of informative scores.\r\nWe
show the compatibility of these machine-measured fower colour scores with the
previously\r\nused manual scores and study impact of external efect on the resulting
scores. Finally, we use\r\nthe machine-measured fower colour scores to ft and
examine a phenotype cline across the\r\nhybrid zone in Planoles using full fower
images as opposed to discrete, manual scores and\r\ncompare it with the genotypic
cline."
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Lenka
full_name: Matejovicova, Lenka
id: 2DFDEC72-F248-11E8-B48F-1D18A9856A87
last_name: Matejovicova
citation:
ama: Matejovicova L. Genetic basis of flower colour as a model for adaptive evolution.
2022. doi:10.15479/at:ista:11128
apa: Matejovicova, L. (2022). Genetic basis of flower colour as a model for adaptive
evolution. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11128
chicago: Matejovicova, Lenka. “Genetic Basis of Flower Colour as a Model for Adaptive
Evolution.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11128.
ieee: L. Matejovicova, “Genetic basis of flower colour as a model for adaptive evolution,”
Institute of Science and Technology Austria, 2022.
ista: Matejovicova L. 2022. Genetic basis of flower colour as a model for adaptive
evolution. Institute of Science and Technology Austria.
mla: Matejovicova, Lenka. Genetic Basis of Flower Colour as a Model for Adaptive
Evolution. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11128.
short: L. Matejovicova, Genetic Basis of Flower Colour as a Model for Adaptive Evolution,
Institute of Science and Technology Austria, 2022.
date_created: 2022-04-07T08:19:54Z
date_published: 2022-04-06T00:00:00Z
date_updated: 2023-06-23T06:26:41Z
day: '06'
ddc:
- '576'
- '582'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
doi: 10.15479/at:ista:11128
file:
- access_level: open_access
checksum: e9609bc4e8f8e20146fc1125fd4f1bf7
content_type: application/pdf
creator: cchlebak
date_created: 2022-04-07T08:11:34Z
date_updated: 2022-04-07T08:11:34Z
file_id: '11129'
file_name: LenkaPhD_Official_PDFA.pdf
file_size: 11906472
relation: main_file
- access_level: closed
checksum: 99d67040432fd07a225643a212ee8588
content_type: application/x-zip-compressed
creator: cchlebak
date_created: 2022-04-07T08:11:51Z
date_updated: 2022-04-07T08:11:51Z
file_id: '11130'
file_name: LenkaPhD Official_source.zip
file_size: 23036766
relation: source_file
file_date_updated: 2022-04-07T08:11:51Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '112'
publication_identifier:
isbn:
- 978-3-99078-016-9
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: Genetic basis of flower colour as a model for adaptive evolution
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '11945'
abstract:
- lang: eng
text: "G protein-coupled receptors (GPCRs) respond to specific ligands and regulate
multiple processes ranging from cell growth and immune responses to neuronal signal
transmission. However, ligands for many GPCRs remain unknown, suffer from off-target
effects or have poor bioavailability. Additional challenges exist to dissect cell-type
specific responses when the same GPCR is expressed on several cell types within
the body. Here, we overcome these limitations by engineering DREADD-based GPCR
chimeras that selectively bind their agonist clozapine-N-oxide (CNO) and mimic
a GPCR-of-interest in a desired cell type.\r\nWe validated our approach with β2-adrenergic
receptor (β2AR/ADRB2) and show that our chimeric DREADD-β2AR triggers comparable
responses on second messenger and kinase activity, post-translational modifications,
and protein-protein interactions. Since β2AR is also enriched in microglia, which
can drive inflammation in the central nervous system, we expressed chimeric DREADD-β2AR
in primary microglia and successfully recapitulate β2AR-mediated filopodia formation
through CNO stimulation. To dissect the role of selected GPCRs during microglial
inflammation, we additionally generated DREADD-based chimeras for microglia-enriched
GPR65 and GPR109A/HCAR2. In a microglia cell line, DREADD-β2AR and DREADD-GPR65
both modulated the inflammatory response with a similar profile as endogenously
expressed β2AR, while DREADD-GPR109A showed no impact.\r\nOur DREADD-based approach
provides the means to obtain mechanistic and functional insights into GPCR signaling
on a cell-type specific level."
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Rouven
full_name: Schulz, Rouven
id: 4C5E7B96-F248-11E8-B48F-1D18A9856A87
last_name: Schulz
orcid: 0000-0001-5297-733X
citation:
ama: Schulz R. Chimeric G protein-coupled receptors mimic distinct signaling pathways
and modulate microglia function. 2022. doi:10.15479/at:ista:11945
apa: Schulz, R. (2022). Chimeric G protein-coupled receptors mimic distinct signaling
pathways and modulate microglia function. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:11945
chicago: Schulz, Rouven. “Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
Pathways and Modulate Microglia Function.” Institute of Science and Technology
Austria, 2022. https://doi.org/10.15479/at:ista:11945.
ieee: R. Schulz, “Chimeric G protein-coupled receptors mimic distinct signaling
pathways and modulate microglia function,” Institute of Science and Technology
Austria, 2022.
ista: Schulz R. 2022. Chimeric G protein-coupled receptors mimic distinct signaling
pathways and modulate microglia function. Institute of Science and Technology
Austria.
mla: Schulz, Rouven. Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
Pathways and Modulate Microglia Function. Institute of Science and Technology
Austria, 2022, doi:10.15479/at:ista:11945.
short: R. Schulz, Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
Pathways and Modulate Microglia Function, Institute of Science and Technology
Austria, 2022.
date_created: 2022-08-23T11:33:11Z
date_published: 2022-08-23T00:00:00Z
date_updated: 2023-08-03T13:02:26Z
day: '23'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SaSi
doi: 10.15479/at:ista:11945
file:
- access_level: open_access
checksum: 61b1b666a210ff7cdd0e95ea75207a13
content_type: application/pdf
creator: rschulz
date_created: 2022-08-25T08:59:57Z
date_updated: 2022-08-25T08:59:57Z
file_id: '11970'
file_name: Thesis_Rouven_Schulz_2022_final.pdf
file_size: 28079331
relation: main_file
success: 1
- access_level: closed
checksum: 2b8f95ea1c134dbdb927b41b1dbeeeb5
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: rschulz
date_created: 2022-08-25T09:00:11Z
date_updated: 2022-08-25T09:33:31Z
file_id: '11971'
file_name: Thesis_Rouven_Schulz_2022_final.docx
file_size: 27226963
relation: source_file
file_date_updated: 2022-08-25T09:33:31Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '133'
project:
- _id: 267F75D8-B435-11E9-9278-68D0E5697425
name: Modulating microglia through G protein-coupled receptor (GPCR) signaling
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11995'
relation: dissertation_contains
status: public
status: public
supervisor:
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
title: Chimeric G protein-coupled receptors mimic distinct signaling pathways and
modulate microglia function
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '12390'
abstract:
- lang: eng
text: "The scope of this thesis is to study quantum systems exhibiting a continuous
symmetry that\r\nis broken on the level of the corresponding effective theory.
In particular we are going to\r\ninvestigate translation-invariant Bose gases
in the mean field limit, effectively described by\r\nthe Hartree functional, and
the Fröhlich Polaron in the regime of strong coupling, effectively\r\ndescribed
by the Pekar functional. The latter is a model describing the interaction between
a\r\ncharged particle and the optical modes of a polar crystal. Regarding the
former, we assume in\r\naddition that the particles in the gas are unconfined,
and typically we will consider particles\r\nthat are subject to an attractive
interaction. In both cases the ground state energy of the\r\nHamiltonian is not
a proper eigenvalue due to the underlying translation-invariance, while on\r\nthe
contrary there exists a whole invariant orbit of minimizers for the corresponding
effective\r\nfunctionals. Both, the absence of proper eigenstates and the broken
symmetry of the effective\r\ntheory, make the study significantly more involved
and it is the content of this thesis to\r\ndevelop a frameworks which allows for
a systematic way to circumvent these issues.\r\nIt is a well-established result
that the ground state energy of Bose gases in the mean field limit,\r\nas well
as the ground state energy of the Fröhlich Polaron in the regime of strong coupling,
is\r\nto leading order given by the minimal energy of the corresponding effective
theory. As part\r\nof this thesis we identify the sub-leading term in the expansion
of the ground state energy,\r\nwhich can be interpreted as the quantum correction
to the classical energy, since the effective\r\ntheories under consideration can
be seen as classical counterparts.\r\nWe are further going to establish an asymptotic
expression for the energy-momentum relation\r\nof the Fröhlich Polaron in the
strong coupling limit. In the regime of suitably small momenta,\r\nthis asymptotic
expression agrees with the energy-momentum relation of a free particle having\r\nan
effectively increased mass, and we find that this effectively increased mass agrees
with the\r\nconjectured value in the physics literature.\r\nIn addition we will
discuss two unrelated papers written by the author during his stay at ISTA\r\nin
the appendix. The first one concerns the realization of anyons, which are quasi-particles\r\nacquiring
a non-trivial phase under the exchange of two particles, as molecular impurities.\r\nThe
second one provides a classification of those vector fields defined on a given
manifold\r\nthat can be written as the gradient of a given functional with respect
to a suitable metric,\r\nprovided that some mild smoothness assumptions hold.
This classification is subsequently\r\nused to identify those quantum Markov semigroups
that can be written as a gradient flow of\r\nthe relative entropy.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Morris
full_name: Brooks, Morris
id: B7ECF9FC-AA38-11E9-AC9A-0930E6697425
last_name: Brooks
orcid: 0000-0002-6249-0928
citation:
ama: Brooks M. Translation-invariant quantum systems with effectively broken symmetry.
2022. doi:10.15479/at:ista:12390
apa: Brooks, M. (2022). Translation-invariant quantum systems with effectively
broken symmetry. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12390
chicago: Brooks, Morris. “Translation-Invariant Quantum Systems with Effectively
Broken Symmetry.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12390.
ieee: M. Brooks, “Translation-invariant quantum systems with effectively broken
symmetry,” Institute of Science and Technology Austria, 2022.
ista: Brooks M. 2022. Translation-invariant quantum systems with effectively broken
symmetry. Institute of Science and Technology Austria.
mla: Brooks, Morris. Translation-Invariant Quantum Systems with Effectively Broken
Symmetry. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12390.
short: M. Brooks, Translation-Invariant Quantum Systems with Effectively Broken
Symmetry, Institute of Science and Technology Austria, 2022.
date_created: 2023-01-26T10:00:42Z
date_published: 2022-12-15T00:00:00Z
date_updated: 2023-08-07T13:32:09Z
day: '15'
ddc:
- '500'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
doi: 10.15479/at:ista:12390
ec_funded: 1
file:
- access_level: open_access
checksum: b31460e937f33b557abb40ebef02b567
content_type: application/pdf
creator: cchlebak
date_created: 2023-01-26T10:02:34Z
date_updated: 2023-01-26T10:02:34Z
file_id: '12391'
file_name: Brooks_Thesis.pdf
file_size: 3095225
relation: main_file
success: 1
- access_level: closed
checksum: 9751869fa5e7981588ad4228f4fd4bd6
content_type: application/octet-stream
creator: cchlebak
date_created: 2023-01-26T10:02:42Z
date_updated: 2023-01-26T10:02:42Z
file_id: '12392'
file_name: Brooks_Thesis.tex
file_size: 809842
relation: source_file
file_date_updated: 2023-01-26T10:02:42Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '196'
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9005'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
title: Translation-invariant quantum systems with effectively broken symmetry
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '12368'
abstract:
- lang: eng
text: "Metazoan development relies on the formation and remodeling of cell-cell
contacts. The \r\nbinding of adhesion receptors and remodeling of the actomyosin
cell cortex at cell-cell \r\ninteraction sites have been implicated in cell-cell
contact formation. Yet, how these two \r\nprocesses functionally interact to drive
cell-cell contact expansion and strengthening \r\nremains unclear. Here, we study
how primary germ layer progenitor cells from zebrafish \r\nbind to supported lipid
bilayers (SLB) functionalized with E-cadherin ectodomains as an \r\nassay system
for monitoring cell-cell contact formation at high spatiotemporal resolution.
\r\nWe show that cell-cell contact formation represents a two-tiered process:
E-cadherin\x02mediated downregulation of the small GTPase RhoA at the forming
contact leads to both \r\ndepletion of Myosin-2 and decrease of F-actin. This
is followed by centrifugal actin \r\nnetwork flows at the contact triggered by
a sharp gradient of Myosin-2 at the rim of the \r\ncontact zone, with Myosin-2
displaying higher cortical localization outside than inside of \r\nthe contact.
These centrifugal cortical actin flows, in turn, not only further dilute the actin
\r\nnetwork at the contact disc, but also lead to an accumulation of both F-actin
and E\x02cadherin at the contact rim. Eventually, this combination of actomyosin
downregulation \r\nand flows at the contact contribute to the characteristic molecular
organization implicated \r\nin contact formation and maintenance: depletion of
cortical actomyosin at the contact disc, \r\ndriving contact expansion by lowering
interfacial tension at the contact, and accumulation \r\nof both E-cadherin and
F-actin at the contact rim, mechanically linking the contractile \r\ncortices
of the adhering cells. Thus, using a biomimetic assay, we exemplify how \r\nadhesion
signaling and cell mechanics function together to modulate the spatial \r\norganization
of cell-cell contacts."
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: NanoFab
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Feyza N
full_name: Arslan, Feyza N
id: 49DA7910-F248-11E8-B48F-1D18A9856A87
last_name: Arslan
orcid: 0000-0001-5809-9566
citation:
ama: Arslan FN. Remodeling of E-cadherin-mediated contacts via cortical flows.
2022. doi:10.15479/at:ista:12153
apa: Arslan, F. N. (2022). Remodeling of E-cadherin-mediated contacts via cortical
flows. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12153
chicago: Arslan, Feyza N. “Remodeling of E-Cadherin-Mediated Contacts via Cortical
Flows.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12153.
ieee: F. N. Arslan, “Remodeling of E-cadherin-mediated contacts via cortical flows,”
Institute of Science and Technology Austria, 2022.
ista: Arslan FN. 2022. Remodeling of E-cadherin-mediated contacts via cortical
flows. Institute of Science and Technology Austria.
mla: Arslan, Feyza N. Remodeling of E-Cadherin-Mediated Contacts via Cortical
Flows. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12153.
short: F.N. Arslan, Remodeling of E-Cadherin-Mediated Contacts via Cortical Flows,
Institute of Science and Technology Austria, 2022.
date_created: 2023-01-25T10:43:24Z
date_published: 2022-09-29T00:00:00Z
date_updated: 2023-08-08T13:14:10Z
day: '29'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: CaHe
doi: 10.15479/at:ista:12153
ec_funded: 1
file:
- access_level: open_access
checksum: e54a3e69b83ebf166544164afd25608e
content_type: application/pdf
creator: cchlebak
date_created: 2023-01-25T10:52:46Z
date_updated: 2023-01-25T10:52:46Z
file_id: '12369'
file_name: THESIS_FINAL_FArslan_pdfa.pdf
file_size: 14581024
relation: main_file
success: 1
file_date_updated: 2023-01-25T10:52:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '113'
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
publication_identifier:
isbn:
- ' 978-3-99078-025-1 '
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9350'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
title: Remodeling of E-cadherin-mediated contacts via cortical flows
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11362'
abstract:
- lang: eng
text: "Deep learning has enabled breakthroughs in challenging computing problems
and has emerged as the standard problem-solving tool for computer vision and natural
language processing tasks.\r\nOne exception to this trend is safety-critical tasks
where robustness and resilience requirements contradict the black-box nature of
neural networks. \r\nTo deploy deep learning methods for these tasks, it is vital
to provide guarantees on neural network agents' safety and robustness criteria.
\r\nThis can be achieved by developing formal verification methods to verify the
safety and robustness properties of neural networks.\r\n\r\nOur goal is to design,
develop and assess safety verification methods for neural networks to improve
their reliability and trustworthiness in real-world applications.\r\nThis thesis
establishes techniques for the verification of compressed and adversarially trained
models as well as the design of novel neural networks for verifiably safe decision-making.\r\n\r\nFirst,
we establish the problem of verifying quantized neural networks. Quantization
is a technique that trades numerical precision for the computational efficiency
of running a neural network and is widely adopted in industry.\r\nWe show that
neglecting the reduced precision when verifying a neural network can lead to wrong
conclusions about the robustness and safety of the network, highlighting that
novel techniques for quantized network verification are necessary. We introduce
several bit-exact verification methods explicitly designed for quantized neural
networks and experimentally confirm on realistic networks that the network's robustness
and other formal properties are affected by the quantization.\r\n\r\nFurthermore,
we perform a case study providing evidence that adversarial training, a standard
technique for making neural networks more robust, has detrimental effects on the
network's performance. This robustness-accuracy tradeoff has been studied before
regarding the accuracy obtained on classification datasets where each data point
is independent of all other data points. On the other hand, we investigate the
tradeoff empirically in robot learning settings where a both, a high accuracy
and a high robustness, are desirable.\r\nOur results suggest that the negative
side-effects of adversarial training outweigh its robustness benefits in practice.\r\n\r\nFinally,
we consider the problem of verifying safety when running a Bayesian neural network
policy in a feedback loop with systems over the infinite time horizon. Bayesian
neural networks are probabilistic models for learning uncertainties in the data
and are therefore often used on robotic and healthcare applications where data
is inherently stochastic.\r\nWe introduce a method for recalibrating Bayesian
neural networks so that they yield probability distributions over safe decisions
only.\r\nOur method learns a safety certificate that guarantees safety over the
infinite time horizon to determine which decisions are safe in every possible
state of the system.\r\nWe demonstrate the effectiveness of our approach on a
series of reinforcement learning benchmarks."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Mathias
full_name: Lechner, Mathias
id: 3DC22916-F248-11E8-B48F-1D18A9856A87
last_name: Lechner
citation:
ama: Lechner M. Learning verifiable representations. 2022. doi:10.15479/at:ista:11362
apa: Lechner, M. (2022). Learning verifiable representations. Institute of
Science and Technology Austria. https://doi.org/10.15479/at:ista:11362
chicago: Lechner, Mathias. “Learning Verifiable Representations.” Institute of Science
and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11362.
ieee: M. Lechner, “Learning verifiable representations,” Institute of Science and
Technology Austria, 2022.
ista: Lechner M. 2022. Learning verifiable representations. Institute of Science
and Technology Austria.
mla: Lechner, Mathias. Learning Verifiable Representations. Institute of
Science and Technology Austria, 2022, doi:10.15479/at:ista:11362.
short: M. Lechner, Learning Verifiable Representations, Institute of Science and
Technology Austria, 2022.
date_created: 2022-05-12T07:14:01Z
date_published: 2022-05-12T00:00:00Z
date_updated: 2023-08-17T06:58:38Z
day: '12'
ddc:
- '004'
degree_awarded: PhD
department:
- _id: GradSch
- _id: ToHe
doi: 10.15479/at:ista:11362
ec_funded: 1
file:
- access_level: closed
checksum: 8eefa9c7c10ca7e1a2ccdd731962a645
content_type: application/zip
creator: mlechner
date_created: 2022-05-13T12:33:26Z
date_updated: 2022-05-13T12:49:00Z
file_id: '11378'
file_name: src.zip
file_size: 13210143
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checksum: 1b9e1e5a9a83ed9d89dad2f5133dc026
content_type: application/pdf
creator: mlechner
date_created: 2022-05-16T08:02:28Z
date_updated: 2022-05-17T15:19:39Z
file_id: '11382'
file_name: thesis_main-a2.pdf
file_size: 2732536
relation: main_file
file_date_updated: 2022-05-17T15:19:39Z
has_accepted_license: '1'
keyword:
- neural networks
- verification
- machine learning
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nd/4.0/
month: '05'
oa: 1
oa_version: Published Version
page: '124'
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication_identifier:
isbn:
- 978-3-99078-017-6
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10665'
relation: part_of_dissertation
status: public
- id: '10667'
relation: part_of_dissertation
status: public
- id: '11366'
relation: part_of_dissertation
status: public
- id: '7808'
relation: part_of_dissertation
status: public
- id: '10666'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
title: Learning verifiable representations
tmp:
image: /image/cc_by_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nd/4.0/legalcode
name: Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
short: CC BY-ND (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '11473'
abstract:
- lang: eng
text: "The polaron model is a basic model of quantum field theory describing a single
particle\r\ninteracting with a bosonic field. It arises in many physical contexts.
We are mostly concerned\r\nwith models applicable in the context of an impurity
atom in a Bose-Einstein condensate as\r\nwell as the problem of electrons moving
in polar crystals.\r\nThe model has a simple structure in which the interaction
of the particle with the field is given\r\nby a term linear in the field’s creation
and annihilation operators. In this work, we investigate\r\nthe properties of
this model by providing rigorous estimates on various energies relevant to the\r\nproblem.
The estimates are obtained, for the most part, by suitable operator techniques
which\r\nconstitute the principal mathematical substance of the thesis.\r\nThe
first application of these techniques is to derive the polaron model rigorously
from first\r\nprinciples, i.e., from a full microscopic quantum-mechanical many-body
problem involving an\r\nimpurity in an otherwise homogeneous system. We accomplish
this for the N + 1 Bose gas\r\nin the mean-field regime by showing that a suitable
polaron-type Hamiltonian arises at weak\r\ninteractions as a low-energy effective
theory for this problem.\r\nIn the second part, we investigate rigorously the
ground state of the model at fixed momentum\r\nand for large values of the coupling
constant. Qualitatively, the system is expected to display\r\na transition from
the quasi-particle behavior at small momenta, where the dispersion relation\r\nis
parabolic and the particle moves through the medium dragging along a cloud of
phonons, to\r\nthe radiative behavior at larger momenta where the polaron decelerates
and emits free phonons.\r\nAt the same time, in the strong coupling regime, the
bosonic field is expected to behave purely\r\nclassically. Accordingly, the effective
mass of the polaron at strong coupling is conjectured to\r\nbe asymptotically
equal to the one obtained from the semiclassical counterpart of the problem,\r\nfirst
studied by Landau and Pekar in the 1940s. For polaron models with regularized
form\r\nfactors and phonon dispersion relations of superfluid type, i.e., bounded
below by a linear\r\nfunction of the wavenumbers for all phonon momenta as in
the interacting Bose gas, we prove\r\nthat for a large window of momenta below
the radiation threshold, the energy-momentum\r\nrelation at strong coupling is
indeed essentially a parabola with semi-latus rectum equal to the\r\nLandau–Pekar
effective mass, as expected.\r\nFor the Fröhlich polaron describing electrons
in polar crystals where the dispersion relation is\r\nof the optical type and
the form factor is formally UV–singular due to the nature of the point\r\ncharge-dipole
interaction, we are able to give the corresponding upper bound. In contrast to\r\nthe
regular case, this requires the inclusion of the quantum fluctuations of the phonon
field,\r\nwhich makes the problem considerably more difficult.\r\nThe results
are supplemented by studies on the absolute ground-state energy at strong coupling,\r\na
proof of the divergence of the effective mass with the coupling constant for a
wide class of\r\npolaron models, as well as the discussion of the apparent UV
singularity of the Fröhlich model\r\nand the application of the techniques used
for its removal for the energy estimates.\r\n"
acknowledged_ssus:
- _id: SSU
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Krzysztof
full_name: Mysliwy, Krzysztof
id: 316457FC-F248-11E8-B48F-1D18A9856A87
last_name: Mysliwy
citation:
ama: 'Mysliwy K. Polarons in Bose gases and polar crystals: Some rigorous energy
estimates. 2022. doi:10.15479/at:ista:11473'
apa: 'Mysliwy, K. (2022). Polarons in Bose gases and polar crystals: Some rigorous
energy estimates. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11473'
chicago: 'Mysliwy, Krzysztof. “Polarons in Bose Gases and Polar Crystals: Some Rigorous
Energy Estimates.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11473.'
ieee: 'K. Mysliwy, “Polarons in Bose gases and polar crystals: Some rigorous energy
estimates,” Institute of Science and Technology Austria, 2022.'
ista: 'Mysliwy K. 2022. Polarons in Bose gases and polar crystals: Some rigorous
energy estimates. Institute of Science and Technology Austria.'
mla: 'Mysliwy, Krzysztof. Polarons in Bose Gases and Polar Crystals: Some Rigorous
Energy Estimates. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11473.'
short: 'K. Mysliwy, Polarons in Bose Gases and Polar Crystals: Some Rigorous Energy
Estimates, Institute of Science and Technology Austria, 2022.'
date_created: 2022-06-30T12:15:03Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2023-09-07T13:43:52Z
day: '01'
ddc:
- '515'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
doi: 10.15479/at:ista:11473
ec_funded: 1
file:
- access_level: open_access
checksum: 7970714a20a6052f75fb27a6c3e9976e
content_type: application/pdf
creator: kmysliwy
date_created: 2022-07-05T08:12:56Z
date_updated: 2022-07-05T08:12:56Z
file_id: '11486'
file_name: thes1_no_isbn_2_1b.pdf
file_size: 1830973
relation: main_file
success: 1
- access_level: closed
checksum: 647a2011fdf56277096c9350fefe1097
content_type: application/zip
creator: kmysliwy
date_created: 2022-07-05T08:15:52Z
date_updated: 2022-07-05T08:17:12Z
file_id: '11487'
file_name: thes_source.zip
file_size: 5831060
relation: source_file
file_date_updated: 2022-07-05T08:17:12Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '138'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10564'
relation: part_of_dissertation
status: public
- id: '8705'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
title: 'Polarons in Bose gases and polar crystals: Some rigorous energy estimates'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2022'
...
---
_id: '10799'
abstract:
- lang: eng
text: "Because of the increasing popularity of machine learning methods, it is becoming
important to understand the impact of learned components on automated decision-making
systems and to guarantee that their consequences are beneficial to society. In
other words, it is necessary to ensure that machine learning is sufficiently trustworthy
to be used in real-world applications. This thesis studies two properties of machine
learning models that are highly desirable for the\r\nsake of reliability: robustness
and fairness. In the first part of the thesis we study the robustness of learning
algorithms to training data corruption. Previous work has shown that machine learning
models are vulnerable to a range\r\nof training set issues, varying from label
noise through systematic biases to worst-case data manipulations. This is an especially
relevant problem from a present perspective, since modern machine learning methods
are particularly data hungry and therefore practitioners often have to rely on
data collected from various external sources, e.g. from the Internet, from app
users or via crowdsourcing. Naturally, such sources vary greatly in the quality
and reliability of the\r\ndata they provide. With these considerations in mind,
we study the problem of designing machine learning algorithms that are robust
to corruptions in data coming from multiple sources. We show that, in contrast
to the case of a single dataset with outliers, successful learning within this
model is possible both theoretically and practically, even under worst-case data
corruptions. The second part of this thesis deals with fairness-aware machine
learning. There are multiple areas where machine learning models have shown promising
results, but where careful considerations are required, in order to avoid discrimanative
decisions taken by such learned components. Ensuring fairness can be particularly
challenging, because real-world training datasets are expected to contain various
forms of historical bias that may affect the learning process. In this thesis
we show that data corruption can indeed render the problem of achieving fairness
impossible, by tightly characterizing the theoretical limits of fair learning
under worst-case data manipulations. However, assuming access to clean data, we
also show how fairness-aware learning can be made practical in contexts beyond
binary classification, in particular in the challenging learning to rank setting."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Nikola H
full_name: Konstantinov, Nikola H
id: 4B9D76E4-F248-11E8-B48F-1D18A9856A87
last_name: Konstantinov
citation:
ama: Konstantinov NH. Robustness and fairness in machine learning. 2022. doi:10.15479/at:ista:10799
apa: Konstantinov, N. H. (2022). Robustness and fairness in machine learning.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10799
chicago: Konstantinov, Nikola H. “Robustness and Fairness in Machine Learning.”
Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:10799.
ieee: N. H. Konstantinov, “Robustness and fairness in machine learning,” Institute
of Science and Technology Austria, 2022.
ista: Konstantinov NH. 2022. Robustness and fairness in machine learning. Institute
of Science and Technology Austria.
mla: Konstantinov, Nikola H. Robustness and Fairness in Machine Learning.
Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:10799.
short: N.H. Konstantinov, Robustness and Fairness in Machine Learning, Institute
of Science and Technology Austria, 2022.
date_created: 2022-02-28T13:03:49Z
date_published: 2022-03-08T00:00:00Z
date_updated: 2023-10-17T12:31:54Z
day: '08'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: GradSch
- _id: ChLa
doi: 10.15479/at:ista:10799
ec_funded: 1
file:
- access_level: open_access
checksum: 626bc523ae8822d20e635d0e2d95182e
content_type: application/pdf
creator: nkonstan
date_created: 2022-03-06T11:42:54Z
date_updated: 2022-03-06T11:42:54Z
file_id: '10823'
file_name: thesis.pdf
file_size: 4204905
relation: main_file
success: 1
- access_level: closed
checksum: e2ca2b88350ac8ea1515b948885cbcb1
content_type: application/x-zip-compressed
creator: nkonstan
date_created: 2022-03-06T11:42:57Z
date_updated: 2022-03-10T12:11:48Z
file_id: '10824'
file_name: thesis.zip
file_size: 22841103
relation: source_file
file_date_updated: 2022-03-10T12:11:48Z
has_accepted_license: '1'
keyword:
- robustness
- fairness
- machine learning
- PAC learning
- adversarial learning
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '176'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-015-2
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8724'
relation: part_of_dissertation
status: public
- id: '10803'
relation: part_of_dissertation
status: public
- id: '10802'
relation: part_of_dissertation
status: public
- id: '6590'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
title: Robustness and fairness in machine learning
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2022'
...
---
_id: '11626'
abstract:
- lang: eng
text: Plant growth and development is well known to be both, flexible and dynamic.
The high capacity for post-embryonic organ formation and tissue regeneration requires
tightly regulated intercellular communication and coordinated tissue polarization.
One of the most important drivers for patterning and polarity in plant development
is the phytohormone auxin. Auxin has the unique characteristic to establish polarized
channels for its own active directional cell to cell transport. This fascinating
phenomenon is called auxin canalization. Those auxin transport channels are characterized
by the expression and polar, subcellular localization of PIN auxin efflux carriers.
PIN proteins have the ability to dynamically change their localization and auxin
itself can affect this by interfering with trafficking. Most of the underlying
molecular mechanisms of canalization still remain enigmatic. What is known so
far is that canonical auxin signaling is indispensable but also other non-canonical
signaling components are thought to play a role. In order to shed light into the
mysteries auf auxin canalization this study revisits the branches of auxin signaling
in detail. Further a new auxin analogue, PISA, is developed which triggers auxin-like
responses but does not directly activate canonical transcriptional auxin signaling.
We revisit the direct auxin effect on PIN trafficking where we found that, contradictory
to previous observations, auxin is very specifically promoting endocytosis of
PIN2 but has no overall effect on endocytosis. Further, we evaluate which cellular
processes related to PIN subcellular dynamics are involved in the establishment
of auxin conducting channels and the formation of vascular tissue. We are re-evaluating
the function of AUXIN BINDING PROTEIN 1 (ABP1) and provide a comprehensive picture
about its developmental phneotypes and involvement in auxin signaling and canalization.
Lastly, we are focusing on the crosstalk between the hormone strigolactone (SL)
and auxin and found that SL is interfering with essentially all processes involved
in auxin canalization in a non-transcriptional manner. Lastly we identify a new
way of SL perception and signaling which is emanating from mitochondria, is independent
of canonical SL signaling and is modulating primary root growth.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Michelle C
full_name: Gallei, Michelle C
id: 35A03822-F248-11E8-B48F-1D18A9856A87
last_name: Gallei
orcid: 0000-0003-1286-7368
citation:
ama: Gallei MC. Auxin and strigolactone non-canonical signaling regulating development
in Arabidopsis thaliana. 2022. doi:10.15479/at:ista:11626
apa: Gallei, M. C. (2022). Auxin and strigolactone non-canonical signaling regulating
development in Arabidopsis thaliana. Institute of Science and Technology Austria.
https://doi.org/10.15479/at:ista:11626
chicago: Gallei, Michelle C. “Auxin and Strigolactone Non-Canonical Signaling Regulating
Development in Arabidopsis Thaliana.” Institute of Science and Technology Austria,
2022. https://doi.org/10.15479/at:ista:11626.
ieee: M. C. Gallei, “Auxin and strigolactone non-canonical signaling regulating
development in Arabidopsis thaliana,” Institute of Science and Technology Austria,
2022.
ista: Gallei MC. 2022. Auxin and strigolactone non-canonical signaling regulating
development in Arabidopsis thaliana. Institute of Science and Technology Austria.
mla: Gallei, Michelle C. Auxin and Strigolactone Non-Canonical Signaling Regulating
Development in Arabidopsis Thaliana. Institute of Science and Technology Austria,
2022, doi:10.15479/at:ista:11626.
short: M.C. Gallei, Auxin and Strigolactone Non-Canonical Signaling Regulating Development
in Arabidopsis Thaliana, Institute of Science and Technology Austria, 2022.
date_created: 2022-07-20T11:21:53Z
date_published: 2022-07-20T00:00:00Z
date_updated: 2023-11-07T08:20:13Z
day: '20'
ddc:
- '575'
degree_awarded: PhD
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- _id: JiFr
doi: 10.15479/at:ista:11626
ec_funded: 1
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oa: 1
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page: '248'
project:
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call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
publication_identifier:
isbn:
- 978-3-99078-019-0
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
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relation: part_of_dissertation
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relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
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full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Eilon
full_name: Shani, Eilon
last_name: Shani
title: Auxin and strigolactone non-canonical signaling regulating development in Arabidopsis
thaliana
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '12358'
abstract:
- lang: eng
text: "The complex yarn structure of knitted and woven fabrics gives rise to both
a mechanical and\r\nvisual complexity. The small-scale interactions of yarns colliding
with and pulling on each\r\nother result in drastically different large-scale
stretching and bending behavior, introducing\r\nanisotropy, curling, and more.
While simulating cloth as individual yarns can reproduce this\r\ncomplexity and
match the quality of real fabric, it may be too computationally expensive for\r\nlarge
fabrics. On the other hand, continuum-based approaches do not need to discretize
the\r\ncloth at a stitch-level, but it is non-trivial to find a material model
that would replicate the\r\nlarge-scale behavior of yarn fabrics, and they discard
the intricate visual detail. In this thesis,\r\nwe discuss three methods to try
and bridge the gap between small-scale and large-scale yarn\r\nmechanics using
numerical homogenization: fitting a continuum model to periodic yarn simulations,
adding mechanics-aware yarn detail onto thin-shell simulations, and quantitatively\r\nfitting
yarn parameters to physical measurements of real fabric.\r\nTo start, we present
a method for animating yarn-level cloth effects using a thin-shell solver.\r\nWe
first use a large number of periodic yarn-level simulations to build a model of
the potential\r\nenergy density of the cloth, and then use it to compute forces
in a thin-shell simulator. The\r\nresulting simulations faithfully reproduce expected
effects like the stiffening of woven fabrics\r\nand the highly deformable nature
and anisotropy of knitted fabrics at a fraction of the cost of\r\nfull yarn-level
simulation.\r\nWhile our thin-shell simulations are able to capture large-scale
yarn mechanics, they lack\r\nthe rich visual detail of yarn-level simulations.
Therefore, we propose a method to animate\r\nyarn-level cloth geometry on top
of an underlying deforming mesh in a mechanics-aware\r\nfashion in real time.
Using triangle strains to interpolate precomputed yarn geometry, we are\r\nable
to reproduce effects such as knit loops tightening under stretching at negligible
cost.\r\nFinally, we introduce a methodology for inverse-modeling of yarn-level
mechanics of cloth,\r\nbased on the mechanical response of fabrics in the real
world. We compile a database from\r\nphysical tests of several knitted fabrics
used in the textile industry spanning diverse physical\r\nproperties like stiffness,
nonlinearity, and anisotropy. We then develop a system for approximating these
mechanical responses with yarn-level cloth simulation, using homogenized\r\nshell
models to speed up computation and adding some small-but-necessary extensions
to\r\nyarn-level models used in computer graphics.\r\n"
acknowledged_ssus:
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alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Georg
full_name: Sperl, Georg
id: 4DD40360-F248-11E8-B48F-1D18A9856A87
last_name: Sperl
citation:
ama: 'Sperl G. Homogenizing yarn simulations: Large-scale mechanics, small-scale
detail, and quantitative fitting. 2022. doi:10.15479/at:ista:12103'
apa: 'Sperl, G. (2022). Homogenizing yarn simulations: Large-scale mechanics,
small-scale detail, and quantitative fitting. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:12103'
chicago: 'Sperl, Georg. “Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale
Detail, and Quantitative Fitting.” Institute of Science and Technology Austria,
2022. https://doi.org/10.15479/at:ista:12103.'
ieee: 'G. Sperl, “Homogenizing yarn simulations: Large-scale mechanics, small-scale
detail, and quantitative fitting,” Institute of Science and Technology Austria,
2022.'
ista: 'Sperl G. 2022. Homogenizing yarn simulations: Large-scale mechanics, small-scale
detail, and quantitative fitting. Institute of Science and Technology Austria.'
mla: 'Sperl, Georg. Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale
Detail, and Quantitative Fitting. Institute of Science and Technology Austria,
2022, doi:10.15479/at:ista:12103.'
short: 'G. Sperl, Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale
Detail, and Quantitative Fitting, Institute of Science and Technology Austria,
2022.'
date_created: 2023-01-24T10:49:46Z
date_published: 2022-09-22T00:00:00Z
date_updated: 2024-02-28T12:57:46Z
day: '22'
ddc:
- '000'
- '620'
degree_awarded: PhD
department:
- _id: GradSch
- _id: ChWo
doi: 10.15479/at:ista:12103
ec_funded: 1
file:
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creator: cchlebak
date_created: 2023-01-25T12:04:41Z
date_updated: 2023-02-02T09:29:57Z
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date_updated: 2023-02-02T09:33:37Z
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file size of 23MB.
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oa: 1
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project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: Efficient Simulation of Natural Phenomena at Extremely Large Scales
publication_identifier:
isbn:
- 978-3-99078-020-6
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
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relation: part_of_dissertation
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status: public
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relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
title: 'Homogenizing yarn simulations: Large-scale mechanics, small-scale detail,
and quantitative fitting'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '10759'
abstract:
- lang: eng
text: In this Thesis, I study composite quantum impurities with variational techniques,
both inspired by machine learning as well as fully analytic. I supplement this
with exploration of other applications of machine learning, in particular artificial
neural networks, in many-body physics. In Chapters 3 and 4, I study quasiparticle
systems with variational approach. I derive a Hamiltonian describing the angulon
quasiparticle in the presence of a magnetic field. I apply analytic variational
treatment to this Hamiltonian. Then, I introduce a variational approach for non-additive
systems, based on artificial neural networks. I exemplify this approach on the
example of the polaron quasiparticle (Fröhlich Hamiltonian). In Chapter 5, I continue
using artificial neural networks, albeit in a different setting. I apply artificial
neural networks to detect phases from snapshots of two types physical systems.
Namely, I study Monte Carlo snapshots of multilayer classical spin models as well
as molecular dynamics maps of colloidal systems. The main type of networks that
I use here are convolutional neural networks, known for their applicability to
image data.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Wojciech
full_name: Rzadkowski, Wojciech
id: 48C55298-F248-11E8-B48F-1D18A9856A87
last_name: Rzadkowski
orcid: 0000-0002-1106-4419
citation:
ama: Rzadkowski W. Analytic and machine learning approaches to composite quantum
impurities. 2022. doi:10.15479/at:ista:10759
apa: Rzadkowski, W. (2022). Analytic and machine learning approaches to composite
quantum impurities. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10759
chicago: Rzadkowski, Wojciech. “Analytic and Machine Learning Approaches to Composite
Quantum Impurities.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:10759.
ieee: W. Rzadkowski, “Analytic and machine learning approaches to composite quantum
impurities,” Institute of Science and Technology Austria, 2022.
ista: Rzadkowski W. 2022. Analytic and machine learning approaches to composite
quantum impurities. Institute of Science and Technology Austria.
mla: Rzadkowski, Wojciech. Analytic and Machine Learning Approaches to Composite
Quantum Impurities. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:10759.
short: W. Rzadkowski, Analytic and Machine Learning Approaches to Composite Quantum
Impurities, Institute of Science and Technology Austria, 2022.
date_created: 2022-02-16T13:27:37Z
date_published: 2022-02-21T00:00:00Z
date_updated: 2024-02-28T13:01:59Z
day: '21'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MiLe
doi: 10.15479/at:ista:10759
ec_funded: 1
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checksum: 0fc54ad1eaede879c665ac9b53c93e22
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date_updated: 2022-02-21T14:02:54Z
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oa: 1
oa_version: Published Version
page: '120'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
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status: public
- id: '415'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
title: Analytic and machine learning approaches to composite quantum impurities
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2022'
...