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Improving variational quantum algorithms: Innovative initialization techniques and extensions to qudit systems. 2023. doi:10.15479/at:ista:14622","apa":"Sack, S. (2023). Improving variational quantum algorithms: Innovative initialization techniques and extensions to qudit systems. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14622","ieee":"S. Sack, “Improving variational quantum algorithms: Innovative initialization techniques and extensions to qudit systems,” Institute of Science and Technology Austria, 2023.","ista":"Sack S. 2023. Improving variational quantum algorithms: Innovative initialization techniques and extensions to qudit systems. Institute of Science and Technology Austria.","short":"S. Sack, Improving Variational Quantum Algorithms: Innovative Initialization Techniques and Extensions to Qudit Systems, Institute of Science and Technology Austria, 2023.","mla":"Sack, Stefan. Improving Variational Quantum Algorithms: Innovative Initialization Techniques and Extensions to Qudit Systems. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14622.","chicago":"Sack, Stefan. “Improving Variational Quantum Algorithms: Innovative Initialization Techniques and Extensions to Qudit Systems.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14622."},"date_published":"2023-11-30T00:00:00Z"},{"date_published":"2023-12-20T00:00:00Z","page":"226","citation":{"short":"J.A. Stopp, Neutrophils on the Hunt: Migratory Strategies Employed by Neutrophils to Fulfill Their Effector Function, Institute of Science and Technology Austria, 2023.","mla":"Stopp, Julian A. Neutrophils on the Hunt: Migratory Strategies Employed by Neutrophils to Fulfill Their Effector Function. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14697.","chicago":"Stopp, Julian A. “Neutrophils on the Hunt: Migratory Strategies Employed by Neutrophils to Fulfill Their Effector Function.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14697.","ama":"Stopp JA. Neutrophils on the hunt: Migratory strategies employed by neutrophils to fulfill their effector function. 2023. doi:10.15479/at:ista:14697","ieee":"J. A. Stopp, “Neutrophils on the hunt: Migratory strategies employed by neutrophils to fulfill their effector function,” Institute of Science and Technology Austria, 2023.","apa":"Stopp, J. A. (2023). Neutrophils on the hunt: Migratory strategies employed by neutrophils to fulfill their effector function. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14697","ista":"Stopp JA. 2023. Neutrophils on the hunt: Migratory strategies employed by neutrophils to fulfill their effector function. Institute of Science and Technology Austria."},"has_accepted_license":"1","article_processing_charge":"No","day":"20","oa_version":"Published Version","file":[{"access_level":"closed","file_name":"Thesis.pdf","embargo_to":"open_access","creator":"jstopp","file_size":51585778,"content_type":"application/pdf","embargo":"2024-12-20","file_id":"14699","relation":"main_file","checksum":"457927165d5d556305d3086f6b83e5c7","date_created":"2023-12-20T09:35:34Z","date_updated":"2023-12-20T09:35:34Z"},{"checksum":"e8d26449ac461f5e8478a62c9507506f","date_updated":"2023-12-20T10:41:42Z","date_created":"2023-12-20T09:35:35Z","relation":"source_file","file_id":"14700","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_size":69625950,"creator":"jstopp","access_level":"closed","file_name":"Thesis.docx"}],"title":"Neutrophils on the hunt: Migratory strategies employed by neutrophils to fulfill their effector function","status":"public","ddc":["570"],"_id":"14697","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","alternative_title":["ISTA Thesis"],"type":"dissertation","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"supervisor":[{"full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt"}],"degree_awarded":"PhD","doi":"10.15479/at:ista:14697","project":[{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020"}],"publication_identifier":{"issn":["2663 - 337X"],"isbn":["978-3-99078-038-1"]},"month":"12","date_created":"2023-12-18T19:14:28Z","date_updated":"2023-12-21T14:30:02Z","related_material":{"record":[{"id":"6328","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"7885"},{"id":"12272","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"14274"},{"id":"14360","relation":"part_of_dissertation","status":"public"}]},"author":[{"first_name":"Julian A","last_name":"Stopp","id":"489E3F00-F248-11E8-B48F-1D18A9856A87","full_name":"Stopp, Julian A"}],"publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"MiSi"}],"publication_status":"published","year":"2023","ec_funded":1,"file_date_updated":"2023-12-20T10:41:42Z"},{"day":"12","article_processing_charge":"No","has_accepted_license":"1","date_published":"2023-12-12T00:00:00Z","citation":{"short":"L.S. Arathoon, Investigating Inbreeding Depression and the Self-Incompatibility Locus of Antirrhinum Majus, Institute of Science and Technology Austria, 2023.","mla":"Arathoon, Louise S. Investigating Inbreeding Depression and the Self-Incompatibility Locus of Antirrhinum Majus. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14651.","chicago":"Arathoon, Louise S. “Investigating Inbreeding Depression and the Self-Incompatibility Locus of Antirrhinum Majus.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14651.","ama":"Arathoon LS. Investigating inbreeding depression and the self-incompatibility locus of Antirrhinum majus. 2023. doi:10.15479/at:ista:14651","apa":"Arathoon, L. S. (2023). Investigating inbreeding depression and the self-incompatibility locus of Antirrhinum majus. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14651","ieee":"L. S. Arathoon, “Investigating inbreeding depression and the self-incompatibility locus of Antirrhinum majus,” Institute of Science and Technology Austria, 2023.","ista":"Arathoon LS. 2023. Investigating inbreeding depression and the self-incompatibility locus of Antirrhinum majus. Institute of Science and Technology Austria."},"page":"96","abstract":[{"lang":"eng","text":"For self-incompatibility (SI) to be stable in a population, theory predicts that sufficient inbreeding depression (ID) is required: the fitness of offspring from self-mated individuals must be low enough to prevent the spread of self-compatibility (SC). Reviews of natural plant populations have supported this theory, with SI species generally showing high levels of ID. However, there is thought to be an under-sampling of self-incompatible taxa in the current literature. In this thesis, I study inbreeding depression in the SI plant species Antirrhinum majus using both greenhouse crosses and a large collected field dataset. Additionally, the gametophytic S-locus of A. majus is highly heterozygous and polymorphic, thus making assembly and discovery of S-alleles very difficult. Here, 206 new alleles of the male component SLFs are presented, along with a phylogeny showing the high conservation with alleles from another Antirrhinum species. Lastly, selected sites within the protein structure of SLFs are investigated, with one site in particular highlighted as potentially being involved in the SI recognition mechanism."}],"type":"dissertation","alternative_title":["ISTA Thesis"],"file":[{"checksum":"520bdb61e95e66070e02824947d2c5fa","success":1,"date_created":"2023-12-13T15:37:55Z","date_updated":"2023-12-13T15:37:55Z","relation":"main_file","file_id":"14684","file_size":34101468,"content_type":"application/pdf","creator":"larathoo","access_level":"open_access","file_name":"Phd_Thesis_LA.pdf"},{"content_type":"application/zip","file_size":31052872,"creator":"larathoo","file_name":"Phd_Thesis_LA.zip","access_level":"closed","date_created":"2023-12-13T15:42:23Z","date_updated":"2023-12-14T08:58:18Z","checksum":"d8e59afd0817c98fba2564a264508e5c","relation":"source_file","file_id":"14685"},{"creator":"larathoo","file_size":10713896,"content_type":"application/zip","file_name":"Supplementary_Materials.zip","access_level":"closed","date_updated":"2023-12-14T08:58:18Z","date_created":"2023-12-11T19:24:59Z","checksum":"9a778c949932286f4519e1f1fca2820d","file_id":"14681","relation":"supplementary_material"}],"oa_version":"Published Version","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","_id":"14651","title":"Investigating inbreeding depression and the self-incompatibility locus of Antirrhinum majus","status":"public","ddc":["570"],"month":"12","publication_identifier":{"issn":["2663 - 337X"]},"doi":"10.15479/at:ista:14651","degree_awarded":"PhD","acknowledged_ssus":[{"_id":"ScienComp"}],"supervisor":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton","full_name":"Barton, Nicholas H"}],"language":[{"iso":"eng"}],"oa":1,"project":[{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"International IST Doctoral Program"}],"file_date_updated":"2023-12-14T08:58:18Z","ec_funded":1,"author":[{"first_name":"Louise S","last_name":"Arathoon","id":"2CFCFF98-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1771-714X","full_name":"Arathoon, Louise S"}],"related_material":{"record":[{"id":"11411","relation":"part_of_dissertation","status":"public"}]},"date_updated":"2023-12-22T11:04:45Z","date_created":"2023-12-11T19:30:37Z","year":"2023","publication_status":"published","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"NiBa"}]},{"file_date_updated":"2023-11-15T13:44:24Z","ec_funded":1,"author":[{"last_name":"Zikelic","first_name":"Dorde","orcid":"0000-0002-4681-1699","id":"294AA7A6-F248-11E8-B48F-1D18A9856A87","full_name":"Zikelic, Dorde"}],"related_material":{"record":[{"id":"1194","relation":"part_of_dissertation","status":"public"},{"id":"12000","status":"public","relation":"part_of_dissertation"},{"id":"9644","relation":"part_of_dissertation","status":"public"},{"id":"12511","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"14600"},{"relation":"part_of_dissertation","status":"public","id":"14601"},{"status":"public","relation":"part_of_dissertation","id":"10414"}]},"date_created":"2023-11-15T13:39:10Z","date_updated":"2024-01-16T11:58:15Z","year":"2023","publication_status":"published","department":[{"_id":"KrCh"},{"_id":"GradSch"}],"publisher":"Institute of Science and Technology Austria","month":"11","publication_identifier":{"issn":["2663 - 337X"],"isbn":["978-3-99078-036-7"]},"doi":"10.15479/14539","supervisor":[{"orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu"}],"degree_awarded":"PhD","language":[{"iso":"eng"}],"oa":1,"tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)"},"project":[{"grant_number":"863818","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020","name":"Formal Methods for Stochastic Models: Algorithms and Applications"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","name":"International IST Doctoral Program","call_identifier":"H2020"}],"abstract":[{"lang":"eng","text":"Stochastic systems provide a formal framework for modelling and quantifying uncertainty in systems and have been widely adopted in many application domains. Formal\r\nverification and control of finite state stochastic systems, a subfield of formal methods\r\nalso known as probabilistic model checking, is well studied. In contrast, formal verification and control of infinite state stochastic systems have received comparatively\r\nless attention. However, infinite state stochastic systems commonly arise in practice.\r\nFor instance, probabilistic models that contain continuous probability distributions such\r\nas normal or uniform, or stochastic dynamical systems which are a classical model for\r\ncontrol under uncertainty, both give rise to infinite state systems.\r\nThe goal of this thesis is to contribute to laying theoretical and algorithmic foundations\r\nof fully automated formal verification and control of infinite state stochastic systems,\r\nwith a particular focus on systems that may be executed over a long or infinite time.\r\nWe consider formal verification of infinite state stochastic systems in the setting of\r\nstatic analysis of probabilistic programs and formal control in the setting of controller\r\nsynthesis in stochastic dynamical systems. For both problems, we present some of the\r\nfirst fully automated methods for probabilistic (a.k.a. quantitative) reachability and\r\nsafety analysis applicable to infinite time horizon systems. We also advance the state\r\nof the art of probability 1 (a.k.a. qualitative) reachability analysis for both problems.\r\nFinally, for formal controller synthesis in stochastic dynamical systems, we present a\r\nnovel framework for learning neural network control policies in stochastic dynamical\r\nsystems with formal guarantees on correctness with respect to quantitative reachability,\r\nsafety or reach-avoid specifications.\r\n"}],"type":"dissertation","alternative_title":["ISTA Thesis"],"oa_version":"Published Version","file":[{"file_name":"main.pdf","access_level":"open_access","file_size":2116426,"content_type":"application/pdf","creator":"cchlebak","relation":"main_file","file_id":"14540","date_created":"2023-11-15T13:43:28Z","date_updated":"2023-11-15T13:43:28Z","checksum":"f23e002b0059ca78e1fbb864da52dd7e","success":1},{"file_size":35884057,"content_type":"application/x-zip-compressed","creator":"cchlebak","access_level":"closed","file_name":"thesis_source.zip","checksum":"80ca37618a3c7b59866875f8be9b15ed","date_created":"2023-11-15T13:44:24Z","date_updated":"2023-11-15T13:44:24Z","relation":"source_file","file_id":"14541"}],"_id":"14539","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","status":"public","title":"Automated verification and control of infinite state stochastic systems","ddc":["000"],"day":"15","article_processing_charge":"No","date_published":"2023-11-15T00:00:00Z","citation":{"short":"D. Zikelic, Automated Verification and Control of Infinite State Stochastic Systems, Institute of Science and Technology Austria, 2023.","mla":"Zikelic, Dorde. Automated Verification and Control of Infinite State Stochastic Systems. Institute of Science and Technology Austria, 2023, doi:10.15479/14539.","chicago":"Zikelic, Dorde. “Automated Verification and Control of Infinite State Stochastic Systems.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/14539.","ama":"Zikelic D. Automated verification and control of infinite state stochastic systems. 2023. doi:10.15479/14539","apa":"Zikelic, D. (2023). Automated verification and control of infinite state stochastic systems. Institute of Science and Technology Austria. https://doi.org/10.15479/14539","ieee":"D. Zikelic, “Automated verification and control of infinite state stochastic systems,” Institute of Science and Technology Austria, 2023.","ista":"Zikelic D. 2023. Automated verification and control of infinite state stochastic systems. Institute of Science and Technology Austria."},"page":"256"},{"publication_identifier":{"issn":["2663 - 337X"]},"month":"05","oa":1,"project":[{"name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","call_identifier":"H2020","_id":"25444568-B435-11E9-9278-68D0E5697425","grant_number":"715508"},{"name":"Molecular Drug Targets","call_identifier":"FWF","grant_number":"W1232-B24","_id":"2548AE96-B435-11E9-9278-68D0E5697425"}],"doi":"10.15479/at:ista:13107","language":[{"iso":"eng"}],"supervisor":[{"full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","first_name":"Gaia","last_name":"Novarino"}],"acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"},{"_id":"EM-Fac"}],"degree_awarded":"PhD","ec_funded":1,"file_date_updated":"2023-06-07T08:41:49Z","year":"2023","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"GaNo"}],"publication_status":"published","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"12802"}]},"author":[{"full_name":"Knaus, Lisa","last_name":"Knaus","first_name":"Lisa","id":"3B2ABCF4-F248-11E8-B48F-1D18A9856A87"}],"date_created":"2023-06-01T09:05:24Z","date_updated":"2024-02-07T08:03:33Z","has_accepted_license":"1","article_processing_charge":"No","day":"31","citation":{"ieee":"L. Knaus, “The metabolism of the developing brain : How large neutral amino acids modulate perinatal neuronal excitability and survival,” Institute of Science and Technology Austria, 2023.","apa":"Knaus, L. (2023). The metabolism of the developing brain : How large neutral amino acids modulate perinatal neuronal excitability and survival. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13107","ista":"Knaus L. 2023. The metabolism of the developing brain : How large neutral amino acids modulate perinatal neuronal excitability and survival. Institute of Science and Technology Austria.","ama":"Knaus L. The metabolism of the developing brain : How large neutral amino acids modulate perinatal neuronal excitability and survival. 2023. doi:10.15479/at:ista:13107","chicago":"Knaus, Lisa. “The Metabolism of the Developing Brain : How Large Neutral Amino Acids Modulate Perinatal Neuronal Excitability and Survival.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13107.","short":"L. Knaus, The Metabolism of the Developing Brain : How Large Neutral Amino Acids Modulate Perinatal Neuronal Excitability and Survival, Institute of Science and Technology Austria, 2023.","mla":"Knaus, Lisa. The Metabolism of the Developing Brain : How Large Neutral Amino Acids Modulate Perinatal Neuronal Excitability and Survival. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13107."},"page":"147","date_published":"2023-05-31T00:00:00Z","type":"dissertation","alternative_title":["ISTA Thesis"],"abstract":[{"lang":"eng","text":"Within the human body, the brain exhibits the highest rate of energy consumption amongst all organs, with the majority of generated ATP being utilized to sustain neuronal activity. Therefore, the metabolism of the mature cerebral cortex is geared towards preserving metabolic homeostasis whilst generating significant amounts of energy. This requires a precise interplay between diverse metabolic pathways, spanning from a tissue-wide scale to the level of individual neurons. Disturbances to this delicate metabolic equilibrium, such as those resulting from maternal malnutrition\r\nor mutations affecting metabolic enzymes, often result in neuropathological variants of neurodevelopment. For instance, mutations in SLC7A5, a transporter of metabolically essential large neutral amino acids (LNAAs), have been associated with autism and microcephaly. However, despite recent progress in the field, the extent of metabolic restructuring that occurs within the developing brain and the corresponding alterations in nutrient demands during various critical periods remain largely unknown. To investigate this, we performed metabolomic profiling of the murine cerebral cortex to characterize the metabolic state of the forebrain at different developmental stages. We found that the developing cortex undergoes substantial metabolic reprogramming, with specific sets of metabolites displaying stage-specific changes. According to our observations, we determined a distinct temporal period in postnatal development during which the cortex displays heightened reliance on LNAAs. Hence, using a conditional knock-out mouse model, we deleted Slc7a5 in neural cells, allowing us to monitor the impact of a perturbed neuronal metabolic state across multiple developmental stages of corticogenesis. We found that manipulating the levels of essential LNAAs in cortical neurons in vivo affects one particular perinatal developmental period critical for cortical network refinement. Abnormally low intracellular LNAA levels result in cell-autonomous alterations in neuronal lipid metabolism, excitability, and survival during this particular time window. Although most of the effects of Slc7a5 deletion on neuronal physiology are transient, derailment of these processes during this brief but crucial window leads to long-term circuit dysfunction in mice. In conclusion, out data indicate that the cerebral cortex undergoes significant metabolic reorganization during development. This process involves the intricate integration of multiple metabolic pathways to ensure optimal neuronal function throughout different developmental stages. Our findings offer a paradigm for understanding how neurons synchronize the expression of nutrient-related genes with their activity to allow proper brain maturation. Further, our results demonstrate that disruptions in these precisely calibrated metabolic processes during critical periods of brain development may result in neuropathological outcomes in mice and in humans."}],"_id":"13107","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","ddc":["570"],"title":"The metabolism of the developing brain : How large neutral amino acids modulate perinatal neuronal excitability and survival","status":"public","file":[{"access_level":"closed","file_name":"Thesis_Lisa Knaus_approved_final.docx","creator":"lknaus","file_size":12991551,"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"13112","relation":"source_file","checksum":"4b69a4ac0bbf4163d59c0b58dcb4f2c3","date_created":"2023-06-01T13:48:41Z","date_updated":"2023-06-01T13:48:41Z"},{"relation":"main_file","file_id":"13114","date_updated":"2023-06-07T08:41:49Z","date_created":"2023-06-02T09:47:29Z","checksum":"6903d152aa01181d87a696085af31c83","file_name":"Thesis_Lisa Knaus_approved_final_pdfa2b.pdf","access_level":"open_access","content_type":"application/pdf","file_size":9309015,"creator":"lknaus"}],"oa_version":"Published Version"}]