[{"scopus_import":"1","day":"01","article_processing_charge":"No","article_type":"review","page":"3-11","publication":"Clinical Genetics","citation":{"chicago":"Avagliano, Laura, Ilaria Parenti, Paolo Grazioli, Elisabetta Di Fede, Chiara Parodi, Milena Mariani, Frank J. Kaiser, Angelo Selicorni, Cristina Gervasini, and Valentina Massa. “Chromatinopathies: A Focus on Cornelia de Lange Syndrome.” Clinical Genetics. Wiley, 2020. https://doi.org/10.1111/cge.13674.","mla":"Avagliano, Laura, et al. “Chromatinopathies: A Focus on Cornelia de Lange Syndrome.” Clinical Genetics, vol. 97, no. 1, Wiley, 2020, pp. 3–11, doi:10.1111/cge.13674.","short":"L. Avagliano, I. Parenti, P. Grazioli, E. Di Fede, C. Parodi, M. Mariani, F.J. Kaiser, A. Selicorni, C. Gervasini, V. Massa, Clinical Genetics 97 (2020) 3–11.","ista":"Avagliano L, Parenti I, Grazioli P, Di Fede E, Parodi C, Mariani M, Kaiser FJ, Selicorni A, Gervasini C, Massa V. 2020. Chromatinopathies: A focus on Cornelia de Lange syndrome. Clinical Genetics. 97(1), 3–11.","apa":"Avagliano, L., Parenti, I., Grazioli, P., Di Fede, E., Parodi, C., Mariani, M., … Massa, V. (2020). Chromatinopathies: A focus on Cornelia de Lange syndrome. Clinical Genetics. Wiley. https://doi.org/10.1111/cge.13674","ieee":"L. Avagliano et al., “Chromatinopathies: A focus on Cornelia de Lange syndrome,” Clinical Genetics, vol. 97, no. 1. Wiley, pp. 3–11, 2020.","ama":"Avagliano L, Parenti I, Grazioli P, et al. Chromatinopathies: A focus on Cornelia de Lange syndrome. Clinical Genetics. 2020;97(1):3-11. doi:10.1111/cge.13674"},"date_published":"2020-01-01T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"In recent years, many genes have been associated with chromatinopathies classified as “Cornelia de Lange Syndrome‐like.” It is known that the phenotype of these patients becomes less recognizable, overlapping to features characteristic of other syndromes caused by genetic variants affecting different regulators of chromatin structure and function. Therefore, Cornelia de Lange syndrome diagnosis might be arduous due to the seldom discordance between unexpected molecular diagnosis and clinical evaluation. Here, we review the molecular features of Cornelia de Lange syndrome, supporting the hypothesis that “CdLS‐like syndromes” are part of a larger “rare disease family” sharing multiple clinical features and common disrupted molecular pathways."}],"issue":"1","title":"Chromatinopathies: A focus on Cornelia de Lange syndrome","status":"public","intvolume":" 97","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7149","oa_version":"None","month":"01","publication_identifier":{"eissn":["1399-0004"],"issn":["0009-9163"]},"isi":1,"quality_controlled":"1","external_id":{"pmid":["31721174"],"isi":["000562561800001"]},"language":[{"iso":"eng"}],"doi":"10.1111/cge.13674","publication_status":"published","publisher":"Wiley","department":[{"_id":"GaNo"}],"acknowledgement":" Dipartimento DiSS, Università degli Studi di Milano, Grant/Award Number: Linea 2; Fondazione Cariplo, Grant/Award Number: 2015-0783; German Federal Ministry of Education and Research (BMBF), Grant/Award Number: CHROMATIN-Net; Medical Faculty of the University of Lübeck, Grant/Award Number: J09-2017; Nickel & Co S.p.A.; Università degli Studi di Milano, Grant/Award Numbers: Molecular & Translational Medicine PhD Scholarship, Translational Medicine PhD Scholarship","year":"2020","pmid":1,"date_created":"2019-12-04T16:10:59Z","date_updated":"2023-08-17T14:06:20Z","volume":97,"author":[{"first_name":"Laura","last_name":"Avagliano","full_name":"Avagliano, Laura"},{"id":"D93538B0-5B71-11E9-AC62-02EBE5697425","last_name":"Parenti","first_name":"Ilaria","full_name":"Parenti, Ilaria"},{"full_name":"Grazioli, Paolo","last_name":"Grazioli","first_name":"Paolo"},{"first_name":"Elisabetta","last_name":"Di Fede","full_name":"Di Fede, Elisabetta"},{"full_name":"Parodi, Chiara","first_name":"Chiara","last_name":"Parodi"},{"last_name":"Mariani","first_name":"Milena","full_name":"Mariani, Milena"},{"full_name":"Kaiser, Frank J.","last_name":"Kaiser","first_name":"Frank J."},{"full_name":"Selicorni, Angelo","first_name":"Angelo","last_name":"Selicorni"},{"first_name":"Cristina","last_name":"Gervasini","full_name":"Gervasini, Cristina"},{"full_name":"Massa, Valentina","first_name":"Valentina","last_name":"Massa"}]},{"language":[{"iso":"eng"}],"doi":"10.3390/ijms21031042","isi":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"isi":["000522551606028"]},"month":"02","publication_identifier":{"eissn":["14220067"],"issn":["16616596"]},"date_updated":"2023-08-18T06:35:41Z","date_created":"2020-02-16T23:00:49Z","volume":21,"author":[{"last_name":"Latorre-Pellicer","first_name":"Ana","full_name":"Latorre-Pellicer, Ana"},{"full_name":"Ascaso, Ángela","first_name":"Ángela","last_name":"Ascaso"},{"last_name":"Trujillano","first_name":"Laura","full_name":"Trujillano, Laura"},{"first_name":"Marta","last_name":"Gil-Salvador","full_name":"Gil-Salvador, Marta"},{"last_name":"Arnedo","first_name":"Maria","full_name":"Arnedo, Maria"},{"last_name":"Lucia-Campos","first_name":"Cristina","full_name":"Lucia-Campos, Cristina"},{"full_name":"Antoñanzas-Pérez, Rebeca","last_name":"Antoñanzas-Pérez","first_name":"Rebeca"},{"first_name":"Iñigo","last_name":"Marcos-Alcalde","full_name":"Marcos-Alcalde, Iñigo"},{"full_name":"Parenti, Ilaria","id":"D93538B0-5B71-11E9-AC62-02EBE5697425","last_name":"Parenti","first_name":"Ilaria"},{"full_name":"Bueno-Lozano, Gloria","first_name":"Gloria","last_name":"Bueno-Lozano"},{"full_name":"Musio, Antonio","first_name":"Antonio","last_name":"Musio"},{"full_name":"Puisac, Beatriz","last_name":"Puisac","first_name":"Beatriz"},{"first_name":"Frank J.","last_name":"Kaiser","full_name":"Kaiser, Frank J."},{"last_name":"Ramos","first_name":"Feliciano J.","full_name":"Ramos, Feliciano J."},{"full_name":"Gómez-Puertas, Paulino","last_name":"Gómez-Puertas","first_name":"Paulino"},{"last_name":"Pié","first_name":"Juan","full_name":"Pié, Juan"}],"publication_status":"published","department":[{"_id":"GaNo"}],"publisher":"MDPI","year":"2020","file_date_updated":"2020-07-14T12:47:59Z","article_number":"1042","date_published":"2020-02-04T00:00:00Z","article_type":"original","publication":"International Journal of Molecular Sciences","citation":{"chicago":"Latorre-Pellicer, Ana, Ángela Ascaso, Laura Trujillano, Marta Gil-Salvador, Maria Arnedo, Cristina Lucia-Campos, Rebeca Antoñanzas-Pérez, et al. “Evaluating Face2Gene as a Tool to Identify Cornelia de Lange Syndrome by Facial Phenotypes.” International Journal of Molecular Sciences. MDPI, 2020. https://doi.org/10.3390/ijms21031042.","mla":"Latorre-Pellicer, Ana, et al. “Evaluating Face2Gene as a Tool to Identify Cornelia de Lange Syndrome by Facial Phenotypes.” International Journal of Molecular Sciences, vol. 21, no. 3, 1042, MDPI, 2020, doi:10.3390/ijms21031042.","short":"A. Latorre-Pellicer, Á. Ascaso, L. Trujillano, M. Gil-Salvador, M. Arnedo, C. Lucia-Campos, R. Antoñanzas-Pérez, I. Marcos-Alcalde, I. Parenti, G. Bueno-Lozano, A. Musio, B. Puisac, F.J. Kaiser, F.J. Ramos, P. Gómez-Puertas, J. Pié, International Journal of Molecular Sciences 21 (2020).","ista":"Latorre-Pellicer A, Ascaso Á, Trujillano L, Gil-Salvador M, Arnedo M, Lucia-Campos C, Antoñanzas-Pérez R, Marcos-Alcalde I, Parenti I, Bueno-Lozano G, Musio A, Puisac B, Kaiser FJ, Ramos FJ, Gómez-Puertas P, Pié J. 2020. Evaluating Face2Gene as a tool to identify Cornelia de Lange syndrome by facial phenotypes. International Journal of Molecular Sciences. 21(3), 1042.","ieee":"A. Latorre-Pellicer et al., “Evaluating Face2Gene as a tool to identify Cornelia de Lange syndrome by facial phenotypes,” International Journal of Molecular Sciences, vol. 21, no. 3. MDPI, 2020.","apa":"Latorre-Pellicer, A., Ascaso, Á., Trujillano, L., Gil-Salvador, M., Arnedo, M., Lucia-Campos, C., … Pié, J. (2020). Evaluating Face2Gene as a tool to identify Cornelia de Lange syndrome by facial phenotypes. International Journal of Molecular Sciences. MDPI. https://doi.org/10.3390/ijms21031042","ama":"Latorre-Pellicer A, Ascaso Á, Trujillano L, et al. Evaluating Face2Gene as a tool to identify Cornelia de Lange syndrome by facial phenotypes. International Journal of Molecular Sciences. 2020;21(3). doi:10.3390/ijms21031042"},"day":"04","has_accepted_license":"1","article_processing_charge":"No","scopus_import":"1","file":[{"file_id":"7496","relation":"main_file","checksum":"0e6658c4fe329d55d4d9bef01c5b15d0","date_updated":"2020-07-14T12:47:59Z","date_created":"2020-02-18T07:49:22Z","access_level":"open_access","file_name":"2020_IntMolecSciences_Latorre.pdf","creator":"dernst","content_type":"application/pdf","file_size":4271234}],"oa_version":"Published Version","status":"public","title":"Evaluating Face2Gene as a tool to identify Cornelia de Lange syndrome by facial phenotypes","ddc":["570"],"intvolume":" 21","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7488","abstract":[{"lang":"eng","text":"Characteristic or classic phenotype of Cornelia de Lange syndrome (CdLS) is associated with a recognisable facial pattern. However, the heterogeneity in causal genes and the presence of overlapping syndromes have made it increasingly difficult to diagnose only by clinical features. DeepGestalt technology, and its app Face2Gene, is having a growing impact on the diagnosis and management of genetic diseases by analysing the features of affected individuals. Here, we performed a phenotypic study on a cohort of 49 individuals harbouring causative variants in known CdLS genes in order to evaluate Face2Gene utility and sensitivity in the clinical diagnosis of CdLS. Based on the profile images of patients, a diagnosis of CdLS was within the top five predicted syndromes for 97.9% of our cases and even listed as first prediction for 83.7%. The age of patients did not seem to affect the prediction accuracy, whereas our results indicate a correlation between the clinical score and affected genes. Furthermore, each gene presents a different pattern recognition that may be used to develop new neural networks with the goal of separating different genetic subtypes in CdLS. Overall, we conclude that computer-assisted image analysis based on deep learning could support the clinical diagnosis of CdLS."}],"issue":"3","type":"journal_article"},{"file_date_updated":"2020-07-14T12:48:04Z","article_number":"107647","volume":31,"date_created":"2020-05-24T22:00:57Z","date_updated":"2023-08-21T06:27:47Z","author":[{"last_name":"Parenti","first_name":"Ilaria","id":"D93538B0-5B71-11E9-AC62-02EBE5697425","full_name":"Parenti, Ilaria"},{"full_name":"Diab, Farah","first_name":"Farah","last_name":"Diab"},{"first_name":"Sara Ruiz","last_name":"Gil","full_name":"Gil, Sara Ruiz"},{"first_name":"Eskeatnaf","last_name":"Mulugeta","full_name":"Mulugeta, Eskeatnaf"},{"first_name":"Valentina","last_name":"Casa","full_name":"Casa, Valentina"},{"last_name":"Berutti","first_name":"Riccardo","full_name":"Berutti, Riccardo"},{"last_name":"Brouwer","first_name":"Rutger W.W.","full_name":"Brouwer, Rutger W.W."},{"full_name":"Dupé, Valerie","first_name":"Valerie","last_name":"Dupé"},{"full_name":"Eckhold, Juliane","first_name":"Juliane","last_name":"Eckhold"},{"full_name":"Graf, Elisabeth","last_name":"Graf","first_name":"Elisabeth"},{"first_name":"Beatriz","last_name":"Puisac","full_name":"Puisac, Beatriz"},{"first_name":"Feliciano","last_name":"Ramos","full_name":"Ramos, Feliciano"},{"last_name":"Schwarzmayr","first_name":"Thomas","full_name":"Schwarzmayr, Thomas"},{"full_name":"Gines, Macarena Moronta","last_name":"Gines","first_name":"Macarena Moronta"},{"last_name":"Van Staveren","first_name":"Thomas","full_name":"Van Staveren, Thomas"},{"full_name":"Van Ijcken, Wilfred F.J.","last_name":"Van Ijcken","first_name":"Wilfred F.J."},{"last_name":"Strom","first_name":"Tim M.","full_name":"Strom, Tim M."},{"full_name":"Pié, Juan","last_name":"Pié","first_name":"Juan"},{"last_name":"Watrin","first_name":"Erwan","full_name":"Watrin, Erwan"},{"last_name":"Kaiser","first_name":"Frank J.","full_name":"Kaiser, Frank J."},{"last_name":"Wendt","first_name":"Kerstin S.","full_name":"Wendt, Kerstin S."}],"publisher":"Elsevier","department":[{"_id":"GaNo"}],"publication_status":"published","year":"2020","publication_identifier":{"eissn":["22111247"]},"month":"05","language":[{"iso":"eng"}],"doi":"10.1016/j.celrep.2020.107647","quality_controlled":"1","isi":1,"external_id":{"isi":["000535655200005"]},"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"oa":1,"issue":"7","abstract":[{"text":"The NIPBL/MAU2 heterodimer loads cohesin onto chromatin. Mutations inNIPBLaccount for most cases ofthe rare developmental disorder Cornelia de Lange syndrome (CdLS). Here we report aMAU2 variant causing CdLS, a deletion of seven amino acids that impairs the interaction between MAU2 and the NIPBL N terminus.Investigating this interaction, we discovered that MAU2 and the NIPBL N terminus are largely dispensable fornormal cohesin and NIPBL function in cells with a NIPBL early truncating mutation. Despite a predicted fataloutcome of an out-of-frame single nucleotide duplication inNIPBL, engineered in two different cell lines,alternative translation initiation yields a form of NIPBL missing N-terminal residues. This form cannot interactwith MAU2, but binds DNA and mediates cohesin loading. Altogether, our work reveals that cohesin loading can occur independently of functional NIPBL/MAU2 complexes and highlights a novel mechanism protectiveagainst out-of-frame mutations that is potentially relevant for other genetic conditions.","lang":"eng"}],"type":"journal_article","file":[{"file_size":4695682,"content_type":"application/pdf","creator":"dernst","access_level":"open_access","file_name":"2020_CellReports_Parenti.pdf","checksum":"64d8f7467731ee5c166b10b939b8310b","date_updated":"2020-07-14T12:48:04Z","date_created":"2020-05-26T11:05:01Z","relation":"main_file","file_id":"7892"}],"oa_version":"Published Version","intvolume":" 31","status":"public","ddc":["570"],"title":"MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome","_id":"7877","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","has_accepted_license":"1","day":"19","scopus_import":"1","date_published":"2020-05-19T00:00:00Z","article_type":"original","citation":{"ista":"Parenti I, Diab F, Gil SR, Mulugeta E, Casa V, Berutti R, Brouwer RWW, Dupé V, Eckhold J, Graf E, Puisac B, Ramos F, Schwarzmayr T, Gines MM, Van Staveren T, Van Ijcken WFJ, Strom TM, Pié J, Watrin E, Kaiser FJ, Wendt KS. 2020. MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome. Cell Reports. 31(7), 107647.","ieee":"I. Parenti et al., “MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome,” Cell Reports, vol. 31, no. 7. Elsevier, 2020.","apa":"Parenti, I., Diab, F., Gil, S. R., Mulugeta, E., Casa, V., Berutti, R., … Wendt, K. S. (2020). MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2020.107647","ama":"Parenti I, Diab F, Gil SR, et al. MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome. Cell Reports. 2020;31(7). doi:10.1016/j.celrep.2020.107647","chicago":"Parenti, Ilaria, Farah Diab, Sara Ruiz Gil, Eskeatnaf Mulugeta, Valentina Casa, Riccardo Berutti, Rutger W.W. Brouwer, et al. “MAU2 and NIPBL Variants Impair the Heterodimerization of the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome.” Cell Reports. Elsevier, 2020. https://doi.org/10.1016/j.celrep.2020.107647.","mla":"Parenti, Ilaria, et al. “MAU2 and NIPBL Variants Impair the Heterodimerization of the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome.” Cell Reports, vol. 31, no. 7, 107647, Elsevier, 2020, doi:10.1016/j.celrep.2020.107647.","short":"I. Parenti, F. Diab, S.R. Gil, E. Mulugeta, V. Casa, R. Berutti, R.W.W. Brouwer, V. Dupé, J. Eckhold, E. Graf, B. Puisac, F. Ramos, T. Schwarzmayr, M.M. Gines, T. Van Staveren, W.F.J. Van Ijcken, T.M. Strom, J. Pié, E. Watrin, F.J. Kaiser, K.S. Wendt, Cell Reports 31 (2020)."},"publication":"Cell Reports"},{"month":"08","publication_identifier":{"issn":["01662236"],"eissn":["1878108X"]},"isi":1,"quality_controlled":"1","project":[{"name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","call_identifier":"H2020","_id":"25444568-B435-11E9-9278-68D0E5697425","grant_number":"715508"}],"external_id":{"pmid":["32507511"],"isi":["000553090600008"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"language":[{"iso":"eng"}],"doi":"10.1016/j.tins.2020.05.004","file_date_updated":"2020-11-25T09:43:40Z","ec_funded":1,"publication_status":"published","department":[{"_id":"GaNo"}],"publisher":"Elsevier","year":"2020","acknowledgement":"We wish to thank Jasmin Morandell for generously sharing Figure 2. This work was supported by the European Research Council Starting Grant (grant 715508 ) to G.N.","pmid":1,"date_created":"2020-06-14T22:00:49Z","date_updated":"2023-08-21T08:25:31Z","volume":43,"author":[{"full_name":"Parenti, Ilaria","id":"D93538B0-5B71-11E9-AC62-02EBE5697425","last_name":"Parenti","first_name":"Ilaria"},{"last_name":"Garcia Rabaneda","first_name":"Luis E","id":"33D1B084-F248-11E8-B48F-1D18A9856A87","full_name":"Garcia Rabaneda, Luis E"},{"id":"C8E17EDC-D7AA-11E9-B7B7-45ECE5697425","last_name":"Schön","first_name":"Hanna","full_name":"Schön, Hanna"},{"last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia"}],"scopus_import":"1","day":"01","has_accepted_license":"1","article_processing_charge":"No","article_type":"original","page":"608-621","publication":"Trends in Neurosciences","citation":{"short":"I. Parenti, L.E. Garcia Rabaneda, H. Schön, G. Novarino, Trends in Neurosciences 43 (2020) 608–621.","mla":"Parenti, Ilaria, et al. “Neurodevelopmental Disorders: From Genetics to Functional Pathways.” Trends in Neurosciences, vol. 43, no. 8, Elsevier, 2020, pp. 608–21, doi:10.1016/j.tins.2020.05.004.","chicago":"Parenti, Ilaria, Luis E Garcia Rabaneda, Hanna Schön, and Gaia Novarino. “Neurodevelopmental Disorders: From Genetics to Functional Pathways.” Trends in Neurosciences. Elsevier, 2020. https://doi.org/10.1016/j.tins.2020.05.004.","ama":"Parenti I, Garcia Rabaneda LE, Schön H, Novarino G. Neurodevelopmental disorders: From genetics to functional pathways. Trends in Neurosciences. 2020;43(8):608-621. doi:10.1016/j.tins.2020.05.004","apa":"Parenti, I., Garcia Rabaneda, L. E., Schön, H., & Novarino, G. (2020). Neurodevelopmental disorders: From genetics to functional pathways. Trends in Neurosciences. Elsevier. https://doi.org/10.1016/j.tins.2020.05.004","ieee":"I. Parenti, L. E. Garcia Rabaneda, H. Schön, and G. Novarino, “Neurodevelopmental disorders: From genetics to functional pathways,” Trends in Neurosciences, vol. 43, no. 8. Elsevier, pp. 608–621, 2020.","ista":"Parenti I, Garcia Rabaneda LE, Schön H, Novarino G. 2020. Neurodevelopmental disorders: From genetics to functional pathways. Trends in Neurosciences. 43(8), 608–621."},"date_published":"2020-08-01T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development and function and are characterized by wide genetic and clinical variability. In this review, we discuss the multiple factors that influence the clinical presentation of NDDs, with particular attention to gene vulnerability, mutational load, and the two-hit model. Despite the complex architecture of\r\nmutational events associated with NDDs, the various proteins involved appear to converge on common pathways, such as synaptic plasticity/function, chromatin remodelers and the mammalian target of rapamycin (mTOR) pathway. A thorough understanding of the mechanisms behind these pathways will hopefully lead to the identification of candidates that could be targeted for treatment approaches."}],"issue":"8","status":"public","title":"Neurodevelopmental disorders: From genetics to functional pathways","ddc":["570"],"intvolume":" 43","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7957","oa_version":"Published Version","file":[{"success":1,"checksum":"67db0251b1d415ae59005f876fcf9e34","date_created":"2020-11-25T09:43:40Z","date_updated":"2020-11-25T09:43:40Z","file_id":"8805","relation":"main_file","creator":"dernst","content_type":"application/pdf","file_size":1439550,"access_level":"open_access","file_name":"2020_TrendsNeuroscience_Parenti.pdf"}]}]