---
_id: '320'
abstract:
- lang: eng
text: 'Fast-spiking, parvalbumin-expressing GABAergic interneurons (PV+-BCs) express
a complex machinery of rapid signaling mechanisms, including specialized voltage-gated
ion channels to generate brief action potentials (APs). However, short APs are
associated with overlapping Na+ and K+ fluxes and are therefore energetically
expensive. How the potentially vicious combination of high AP frequency and inefficient
spike generation can be reconciled with limited energy supply is presently unclear.
To address this question, we performed direct recordings from the PV+-BC axon,
the subcellular structure where active conductances for AP initiation and propagation
are located. Surprisingly, the energy required for the AP was, on average, only
∼1.6 times the theoretical minimum. High energy efficiency emerged from the combination
of fast inactivation of Na+ channels and delayed activation of Kv3-type K+ channels,
which minimized ion flux overlap during APs. Thus, the complementary tuning of
axonal Na+ and K+ channel gating optimizes both fast signaling properties and
metabolic efficiency. Hu et al. demonstrate that action potentials in parvalbumin-expressing
GABAergic interneuron axons are energetically efficient, which is highly unexpected
given their brief duration. High energy efficiency emerges from the combination
of fast inactivation of voltage-gated Na+ channels and delayed activation of Kv3
channels in the axon. '
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Hua
full_name: Hu, Hua
id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
last_name: Hu
- first_name: Fabian
full_name: Roth, Fabian
last_name: Roth
- first_name: David H
full_name: Vandael, David H
id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
last_name: Vandael
orcid: 0000-0001-7577-1676
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Hu H, Roth F, Vandael DH, Jonas PM. Complementary tuning of Na+ and K+ channel
gating underlies fast and energy-efficient action potentials in GABAergic interneuron
axons. Neuron. 2018;98(1):156-165. doi:10.1016/j.neuron.2018.02.024
apa: Hu, H., Roth, F., Vandael, D. H., & Jonas, P. M. (2018). Complementary
tuning of Na+ and K+ channel gating underlies fast and energy-efficient action
potentials in GABAergic interneuron axons. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2018.02.024
chicago: Hu, Hua, Fabian Roth, David H Vandael, and Peter M Jonas. “Complementary
Tuning of Na+ and K+ Channel Gating Underlies Fast and Energy-Efficient Action
Potentials in GABAergic Interneuron Axons.” Neuron. Elsevier, 2018. https://doi.org/10.1016/j.neuron.2018.02.024.
ieee: H. Hu, F. Roth, D. H. Vandael, and P. M. Jonas, “Complementary tuning of Na+
and K+ channel gating underlies fast and energy-efficient action potentials in
GABAergic interneuron axons,” Neuron, vol. 98, no. 1. Elsevier, pp. 156–165,
2018.
ista: Hu H, Roth F, Vandael DH, Jonas PM. 2018. Complementary tuning of Na+ and
K+ channel gating underlies fast and energy-efficient action potentials in GABAergic
interneuron axons. Neuron. 98(1), 156–165.
mla: Hu, Hua, et al. “Complementary Tuning of Na+ and K+ Channel Gating Underlies
Fast and Energy-Efficient Action Potentials in GABAergic Interneuron Axons.” Neuron,
vol. 98, no. 1, Elsevier, 2018, pp. 156–65, doi:10.1016/j.neuron.2018.02.024.
short: H. Hu, F. Roth, D.H. Vandael, P.M. Jonas, Neuron 98 (2018) 156–165.
date_created: 2018-12-11T11:45:48Z
date_published: 2018-04-04T00:00:00Z
date_updated: 2023-09-11T12:45:10Z
day: '04'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2018.02.024
ec_funded: 1
external_id:
isi:
- '000429192100016'
file:
- access_level: open_access
checksum: 76070f3729f9c603e1080d0151aa2b11
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creator: dernst
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oa: 1
oa_version: Published Version
page: 156 - 165
project:
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call_identifier: FP7
grant_number: '268548'
name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
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call_identifier: FWF
grant_number: P24909-B24
name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '7545'
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/a-certain-type-of-neurons-is-more-energy-efficient-than-previously-assumed/
scopus_import: '1'
status: public
title: Complementary tuning of Na+ and K+ channel gating underlies fast and energy-efficient
action potentials in GABAergic interneuron axons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 98
year: '2018'
...
---
_id: '2062'
abstract:
- lang: eng
text: The success story of fast-spiking, parvalbumin-positive (PV+) GABAergic interneurons
(GABA, γ-aminobutyric acid) in the mammalian central nervous system is noteworthy.
In 1995, the properties of these interneurons were completely unknown. Twenty
years later, thanks to the massive use of subcellular patch-clamp techniques,
simultaneous multiple-cell recording, optogenetics, in vivo measurements, and
computational approaches, our knowledge about PV+ interneurons became more extensive
than for several types of pyramidal neurons. These findings have implications
beyond the “small world” of basic research on GABAergic cells. For example, the
results provide a first proof of principle that neuroscientists might be able
to close the gaps between the molecular, cellular, network, and behavioral levels,
representing one of the main challenges at the present time. Furthermore, the
results may form the basis for PV+ interneurons as therapeutic targets for brain
disease in the future. However, much needs to be learned about the basic function
of these interneurons before clinical neuroscientists will be able to use PV+
interneurons for therapeutic purposes.
article_number: '1255263'
author:
- first_name: Hua
full_name: Hu, Hua
id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
last_name: Hu
- first_name: Jian
full_name: Gan, Jian
id: 3614E438-F248-11E8-B48F-1D18A9856A87
last_name: Gan
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Hu H, Gan J, Jonas PM. Fast-spiking parvalbumin^+ GABAergic interneurons:
From cellular design to microcircuit function. Science. 2014;345(6196).
doi:10.1126/science.1255263'
apa: 'Hu, H., Gan, J., & Jonas, P. M. (2014). Fast-spiking parvalbumin^+ GABAergic
interneurons: From cellular design to microcircuit function. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.1255263'
chicago: 'Hu, Hua, Jian Gan, and Peter M Jonas. “Fast-Spiking Parvalbumin^+ GABAergic
Interneurons: From Cellular Design to Microcircuit Function.” Science.
American Association for the Advancement of Science, 2014. https://doi.org/10.1126/science.1255263.'
ieee: 'H. Hu, J. Gan, and P. M. Jonas, “Fast-spiking parvalbumin^+ GABAergic interneurons:
From cellular design to microcircuit function,” Science, vol. 345, no.
6196. American Association for the Advancement of Science, 2014.'
ista: 'Hu H, Gan J, Jonas PM. 2014. Fast-spiking parvalbumin^+ GABAergic interneurons:
From cellular design to microcircuit function. Science. 345(6196), 1255263.'
mla: 'Hu, Hua, et al. “Fast-Spiking Parvalbumin^+ GABAergic Interneurons: From Cellular
Design to Microcircuit Function.” Science, vol. 345, no. 6196, 1255263,
American Association for the Advancement of Science, 2014, doi:10.1126/science.1255263.'
short: H. Hu, J. Gan, P.M. Jonas, Science 345 (2014).
date_created: 2018-12-11T11:55:29Z
date_published: 2014-08-01T00:00:00Z
date_updated: 2021-01-12T06:55:03Z
day: '01'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1126/science.1255263
ec_funded: 1
file:
- access_level: open_access
checksum: a0036a589037d37e86364fa25cc0a82f
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:00Z
date_updated: 2020-07-14T12:45:27Z
file_id: '5185'
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file_size: 1732723
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has_accepted_license: '1'
intvolume: ' 345'
issue: '6196'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P24909-B24
name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '268548'
name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4984'
pubrep_id: '821'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Fast-spiking parvalbumin^+ GABAergic interneurons: From cellular design to
microcircuit function'
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 345
year: '2014'
...
---
_id: '2228'
abstract:
- lang: eng
text: Fast-spiking, parvalbumin-expressing GABAergic interneurons, a large proportion
of which are basket cells (BCs), have a key role in feedforward and feedback inhibition,
gamma oscillations and complex information processing. For these functions, fast
propagation of action potentials (APs) from the soma to the presynaptic terminals
is important. However, the functional properties of interneuron axons remain elusive.
We examined interneuron axons by confocally targeted subcellular patch-clamp recording
in rat hippocampal slices. APs were initiated in the proximal axon ∼20 μm from
the soma and propagated to the distal axon with high reliability and speed. Subcellular
mapping revealed a stepwise increase of Na^+ conductance density from the soma
to the proximal axon, followed by a further gradual increase in the distal axon.
Active cable modeling and experiments with partial channel block revealed that
low axonal Na^+ conductance density was sufficient for reliability, but high Na^+
density was necessary for both speed of propagation and fast-spiking AP phenotype.
Our results suggest that a supercritical density of Na^+ channels compensates
for the morphological properties of interneuron axons (small segmental diameter,
extensive branching and high bouton density), ensuring fast AP propagation and
high-frequency repetitive firing.
author:
- first_name: Hua
full_name: Hu, Hua
id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
last_name: Hu
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Hu H, Jonas PM. A supercritical density of Na^+ channels ensures fast signaling
in GABAergic interneuron axons. Nature Neuroscience. 2014;17(5):686-693.
doi:10.1038/nn.3678
apa: Hu, H., & Jonas, P. M. (2014). A supercritical density of Na^+ channels
ensures fast signaling in GABAergic interneuron axons. Nature Neuroscience.
Nature Publishing Group. https://doi.org/10.1038/nn.3678
chicago: Hu, Hua, and Peter M Jonas. “A Supercritical Density of Na^+ Channels Ensures
Fast Signaling in GABAergic Interneuron Axons.” Nature Neuroscience. Nature
Publishing Group, 2014. https://doi.org/10.1038/nn.3678.
ieee: H. Hu and P. M. Jonas, “A supercritical density of Na^+ channels ensures fast
signaling in GABAergic interneuron axons,” Nature Neuroscience, vol. 17,
no. 5. Nature Publishing Group, pp. 686–693, 2014.
ista: Hu H, Jonas PM. 2014. A supercritical density of Na^+ channels ensures fast
signaling in GABAergic interneuron axons. Nature Neuroscience. 17(5), 686–693.
mla: Hu, Hua, and Peter M. Jonas. “A Supercritical Density of Na^+ Channels Ensures
Fast Signaling in GABAergic Interneuron Axons.” Nature Neuroscience, vol.
17, no. 5, Nature Publishing Group, 2014, pp. 686–93, doi:10.1038/nn.3678.
short: H. Hu, P.M. Jonas, Nature Neuroscience 17 (2014) 686–693.
date_created: 2018-12-11T11:56:26Z
date_published: 2014-03-23T00:00:00Z
date_updated: 2021-01-12T06:56:08Z
day: '23'
department:
- _id: PeJo
doi: 10.1038/nn.3678
ec_funded: 1
intvolume: ' 17'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286295/
month: '03'
oa: 1
oa_version: Submitted Version
page: 686-693
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '268548'
name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P24909-B24
name: Mechanisms of transmitter release at GABAergic synapses
publication: Nature Neuroscience
publication_identifier:
issn:
- '10976256'
publication_status: published
publisher: Nature Publishing Group
publist_id: '4733'
quality_controlled: '1'
scopus_import: 1
status: public
title: A supercritical density of Na^+ channels ensures fast signaling in GABAergic
interneuron axons
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2014'
...
---
_id: '3258'
abstract:
- lang: eng
text: CA3 pyramidal neurons are important for memory formation and pattern completion
in the hippocampal network. It is generally thought that proximal synapses from
the mossy fibers activate these neurons most efficiently, whereas distal inputs
from the perforant path have a weaker modulatory influence. We used confocally
targeted patch-clamp recording from dendrites and axons to map the activation
of rat CA3 pyramidal neurons at the subcellular level. Our results reveal two
distinct dendritic domains. In the proximal domain, action potentials initiated
in the axon backpropagate actively with large amplitude and fast time course.
In the distal domain, Na+ channel–mediated dendritic spikes are efficiently initiated
by waveforms mimicking synaptic events. CA3 pyramidal neuron dendrites showed
a high Na+-to-K+ conductance density ratio, providing ideal conditions for active
backpropagation and dendritic spike initiation. Dendritic spikes may enhance the
computational power of CA3 pyramidal neurons in the hippocampal network.
acknowledgement: This work was supported by the Deutsche Forschungsgemeinschaft (TR
3/B10) and the European Union (European Research Council Advanced grant to P.J.).
article_processing_charge: No
article_type: original
author:
- first_name: Sooyun
full_name: Kim, Sooyun
id: 394AB1C8-F248-11E8-B48F-1D18A9856A87
last_name: Kim
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
orcid: 0000-0003-2209-5242
- first_name: Hua
full_name: Hu, Hua
id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
last_name: Hu
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Kim S, Guzmán J, Hu H, Jonas PM. Active dendrites support efficient initiation
of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience.
2012;15(4):600-606. doi:10.1038/nn.3060
apa: Kim, S., Guzmán, J., Hu, H., & Jonas, P. M. (2012). Active dendrites support
efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3060
chicago: Kim, Sooyun, José Guzmán, Hua Hu, and Peter M Jonas. “Active Dendrites
Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal
Neurons.” Nature Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nn.3060.
ieee: S. Kim, J. Guzmán, H. Hu, and P. M. Jonas, “Active dendrites support efficient
initiation of dendritic spikes in hippocampal CA3 pyramidal neurons,” Nature
Neuroscience, vol. 15, no. 4. Nature Publishing Group, pp. 600–606, 2012.
ista: Kim S, Guzmán J, Hu H, Jonas PM. 2012. Active dendrites support efficient
initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience.
15(4), 600–606.
mla: Kim, Sooyun, et al. “Active Dendrites Support Efficient Initiation of Dendritic
Spikes in Hippocampal CA3 Pyramidal Neurons.” Nature Neuroscience, vol.
15, no. 4, Nature Publishing Group, 2012, pp. 600–06, doi:10.1038/nn.3060.
short: S. Kim, J. Guzmán, H. Hu, P.M. Jonas, Nature Neuroscience 15 (2012) 600–606.
date_created: 2018-12-11T12:02:18Z
date_published: 2012-04-01T00:00:00Z
date_updated: 2023-09-07T11:43:52Z
day: '01'
department:
- _id: PeJo
doi: 10.1038/nn.3060
external_id:
pmid:
- '22388958'
intvolume: ' 15'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617474/
month: '04'
oa: 1
oa_version: Published Version
page: 600 - 606
pmid: 1
project:
- _id: 25BDE9A4-B435-11E9-9278-68D0E5697425
grant_number: SFB-TR3-TP10B
name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen
publication: Nature Neuroscience
publication_identifier:
issn:
- 1546-1726
publication_status: published
publisher: Nature Publishing Group
publist_id: '3390'
quality_controlled: '1'
related_material:
record:
- id: '2964'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Active dendrites support efficient initiation of dendritic spikes in hippocampal
CA3 pyramidal neurons
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 15
year: '2012'
...
---
_id: '3831'
abstract:
- lang: eng
text: Fast-spiking, parvalbumin-expressing basket cells (BCs) play a key role in
feedforward and feedback inhibition in the hippocampus. However, the dendritic
mechanisms underlying rapid interneuron recruitment have remained unclear. To
quantitatively address this question, we developed detailed passive cable models
of BCs in the dentate gyrus based on dual somatic or somatodendritic recordings
and complete morphologic reconstructions. Both specific membrane capacitance and
axial resistivity were comparable to those of pyramidal neurons, but the average
somatodendritic specific membrane resistance (R(m)) was substantially lower in
BCs. Furthermore, R(m) was markedly nonuniform, being lowest in soma and proximal
dendrites, intermediate in distal dendrites, and highest in the axon. Thus, the
somatodendritic gradient of R(m) was the reverse of that in pyramidal neurons.
Further computational analysis revealed that these unique cable properties accelerate
the time course of synaptic potentials at the soma in response to fast inputs,
while boosting the efficacy of slow distal inputs. These properties will facilitate
both rapid phasic and efficient tonic activation of BCs in hippocampal microcircuits.
author:
- first_name: Anja
full_name: Norenberg, Anja
last_name: Norenberg
- first_name: Hua
full_name: Hua Hu
id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
last_name: Hu
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Norenberg A, Hu H, Vida I, Bartos M, Jonas PM. Distinct nonuniform cable properties
optimize rapid and efficient activation of fast-spiking GABAergic interneurons.
PNAS. 2010;107(2):894-899. doi:10.1073/pnas.0910716107
apa: Norenberg, A., Hu, H., Vida, I., Bartos, M., & Jonas, P. M. (2010). Distinct
nonuniform cable properties optimize rapid and efficient activation of fast-spiking
GABAergic interneurons. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.0910716107
chicago: Norenberg, Anja, Hua Hu, Imre Vida, Marlene Bartos, and Peter M Jonas.
“Distinct Nonuniform Cable Properties Optimize Rapid and Efficient Activation
of Fast-Spiking GABAergic Interneurons.” PNAS. National Academy of Sciences,
2010. https://doi.org/10.1073/pnas.0910716107.
ieee: A. Norenberg, H. Hu, I. Vida, M. Bartos, and P. M. Jonas, “Distinct nonuniform
cable properties optimize rapid and efficient activation of fast-spiking GABAergic
interneurons,” PNAS, vol. 107, no. 2. National Academy of Sciences, pp.
894–9, 2010.
ista: Norenberg A, Hu H, Vida I, Bartos M, Jonas PM. 2010. Distinct nonuniform cable
properties optimize rapid and efficient activation of fast-spiking GABAergic interneurons.
PNAS. 107(2), 894–9.
mla: Norenberg, Anja, et al. “Distinct Nonuniform Cable Properties Optimize Rapid
and Efficient Activation of Fast-Spiking GABAergic Interneurons.” PNAS,
vol. 107, no. 2, National Academy of Sciences, 2010, pp. 894–99, doi:10.1073/pnas.0910716107.
short: A. Norenberg, H. Hu, I. Vida, M. Bartos, P.M. Jonas, PNAS 107 (2010) 894–9.
date_created: 2018-12-11T12:05:24Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:31Z
day: '01'
doi: 10.1073/pnas.0910716107
extern: 1
intvolume: ' 107'
issue: '2'
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818894/#!po=4.16667
month: '01'
oa: 1
page: 894 - 9
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2379'
quality_controlled: 0
status: public
title: Distinct nonuniform cable properties optimize rapid and efficient activation
of fast-spiking GABAergic interneurons
type: journal_article
volume: 107
year: '2010'
...
---
_id: '3830'
abstract:
- lang: eng
text: Fast-spiking, parvalbumin-expressing basket cells (BCs) are important for
feedforward and feedback inhibition. During network activity, BCs respond with
short latency and high temporal precision. It is thought that the specific properties
of input synapses are responsible for rapid recruitment. However, a potential
contribution of active dendritic conductances has not been addressed. We combined
confocal imaging and patch-clamp techniques to obtain simultaneous somatodendritic
recordings from BCs. Action potentials were initiated in the BC axon and backpropagated
into the dendrites with reduced amplitude and little activity dependence. These
properties were explained by a high K+ to Na+ conductance ratio in BC dendrites.
Computational analysis indicated that dendritic K+ channels convey unique integration
properties to BCs, leading to the rapid and temporally precise activation by excitatory
inputs.
author:
- first_name: Hua
full_name: Hua Hu
id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
last_name: Hu
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Hu H, Martina M, Jonas PM. Dendritic mechanisms underlying rapid synaptic activation
of fast-spiking hippocampal interneurons. Science. 2010;327(5961):52-58.
doi:10.1126/science.1177876
apa: Hu, H., Martina, M., & Jonas, P. M. (2010). Dendritic mechanisms underlying
rapid synaptic activation of fast-spiking hippocampal interneurons. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.1177876
chicago: Hu, Hua, Marco Martina, and Peter M Jonas. “Dendritic Mechanisms Underlying
Rapid Synaptic Activation of Fast-Spiking Hippocampal Interneurons.” Science.
American Association for the Advancement of Science, 2010. https://doi.org/10.1126/science.1177876.
ieee: H. Hu, M. Martina, and P. M. Jonas, “Dendritic mechanisms underlying rapid
synaptic activation of fast-spiking hippocampal interneurons,” Science,
vol. 327, no. 5961. American Association for the Advancement of Science, pp. 52–8,
2010.
ista: Hu H, Martina M, Jonas PM. 2010. Dendritic mechanisms underlying rapid synaptic
activation of fast-spiking hippocampal interneurons. Science. 327(5961), 52–8.
mla: Hu, Hua, et al. “Dendritic Mechanisms Underlying Rapid Synaptic Activation
of Fast-Spiking Hippocampal Interneurons.” Science, vol. 327, no. 5961,
American Association for the Advancement of Science, 2010, pp. 52–58, doi:10.1126/science.1177876.
short: H. Hu, M. Martina, P.M. Jonas, Science 327 (2010) 52–8.
date_created: 2018-12-11T12:05:24Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:30Z
day: '01'
doi: 10.1126/science.1177876
extern: 1
intvolume: ' 327'
issue: '5961'
month: '01'
page: 52 - 8
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2381'
quality_controlled: 0
status: public
title: Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal
interneurons
type: journal_article
volume: 327
year: '2010'
...