[{"project":[{"name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","grant_number":"281511","_id":"257A4776-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"author":[{"first_name":"Charlotte N.","id":"3FC06552-F248-11E8-B48F-1D18A9856A87","last_name":"Boccara","full_name":"Boccara, Charlotte N.","orcid":"0000-0001-7237-5109"},{"last_name":"Nardin","full_name":"Nardin, Michele","orcid":"0000-0001-8849-6570","id":"30BD0376-F248-11E8-B48F-1D18A9856A87","first_name":"Michele"},{"id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","first_name":"Federico","last_name":"Stella","full_name":"Stella, Federico","orcid":"0000-0001-9439-3148"},{"last_name":"O'Neill","full_name":"O'Neill, Joseph","first_name":"Joseph","id":"426376DC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"isi":["000462738000034"]},"article_processing_charge":"No","title":"The entorhinal cognitive map is attracted to goals","citation":{"ista":"Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. 2019. The entorhinal cognitive map is attracted to goals. Science. 363(6434), 1443–1447.","chicago":"Boccara, Charlotte N., Michele Nardin, Federico Stella, Joseph O’Neill, and Jozsef L Csicsvari. “The Entorhinal Cognitive Map Is Attracted to Goals.” Science. American Association for the Advancement of Science, 2019. https://doi.org/10.1126/science.aav4837.","short":"C.N. Boccara, M. Nardin, F. Stella, J. O’Neill, J.L. Csicsvari, Science 363 (2019) 1443–1447.","ieee":"C. N. Boccara, M. Nardin, F. Stella, J. O’Neill, and J. L. Csicsvari, “The entorhinal cognitive map is attracted to goals,” Science, vol. 363, no. 6434. American Association for the Advancement of Science, pp. 1443–1447, 2019.","ama":"Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. The entorhinal cognitive map is attracted to goals. Science. 2019;363(6434):1443-1447. doi:10.1126/science.aav4837","apa":"Boccara, C. N., Nardin, M., Stella, F., O’Neill, J., & Csicsvari, J. L. (2019). The entorhinal cognitive map is attracted to goals. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aav4837","mla":"Boccara, Charlotte N., et al. “The Entorhinal Cognitive Map Is Attracted to Goals.” Science, vol. 363, no. 6434, American Association for the Advancement of Science, 2019, pp. 1443–47, doi:10.1126/science.aav4837."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","quality_controlled":"1","publisher":"American Association for the Advancement of Science","oa":1,"page":"1443-1447","date_published":"2019-03-29T00:00:00Z","doi":"10.1126/science.aav4837","date_created":"2019-04-04T08:39:30Z","isi":1,"has_accepted_license":"1","year":"2019","day":"29","publication":"Science","type":"journal_article","article_type":"original","status":"public","_id":"6194","department":[{"_id":"JoCs"}],"file_date_updated":"2020-07-14T12:47:23Z","date_updated":"2024-03-27T23:30:16Z","ddc":["570"],"scopus_import":"1","month":"03","intvolume":" 363","abstract":[{"lang":"eng","text":"Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric to the hippocampal cognitive map, yet environmental geometrical features have recently been shown to distort the grid structure. Given that the hippocampal role goes beyond space, we tested the influence of nonspatial information on the grid organization. We trained rats to daily learn three new reward locations on a cheeseboard maze while recording from the medial entorhinal cortex and the hippocampal CA1 region. Many grid fields moved toward goal location, leading to long-lasting deformations of the entorhinal map. Therefore, distortions in the grid structure contribute to goal representation during both learning and recall, which demonstrates that grid cells participate in mnemonic coding and do not merely provide a simple metric of space."}],"oa_version":"Submitted Version","volume":363,"issue":"6434","related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/grid-cells-create-treasure-map-in-rat-brain/"}],"record":[{"relation":"popular_science","id":"6062","status":"public"},{"relation":"dissertation_contains","status":"public","id":"11932"}]},"ec_funded":1,"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"publication_status":"published","file":[{"date_created":"2020-05-14T09:11:10Z","file_name":"2019_Science_Boccara.pdf","creator":"dernst","date_updated":"2020-07-14T12:47:23Z","file_size":9045923,"checksum":"5e6b16742cde10a560cfaf2130764da1","file_id":"7826","access_level":"open_access","relation":"main_file","content_type":"application/pdf"}],"language":[{"iso":"eng"}]},{"oa":1,"quality_controlled":"1","publisher":"Nature Publishing Group","publication":"Nature Communications","day":"01","year":"2017","has_accepted_license":"1","date_created":"2018-12-11T11:46:54Z","date_published":"2017-07-01T00:00:00Z","doi":"10.1038/ncomms16032","article_number":"16032","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Simonnet, Jean, Mérie Nassar, Federico Stella, Ivan Cohen, Bertrand Mathon, Charlotte N. Boccara, Richard Miles, and Desdemona Fricker. “Activity Dependent Feedback Inhibition May Maintain Head Direction Signals in Mouse Presubiculum.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms16032.","ista":"Simonnet J, Nassar M, Stella F, Cohen I, Mathon B, Boccara CN, Miles R, Fricker D. 2017. Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. 8, 16032.","mla":"Simonnet, Jean, et al. “Activity Dependent Feedback Inhibition May Maintain Head Direction Signals in Mouse Presubiculum.” Nature Communications, vol. 8, 16032, Nature Publishing Group, 2017, doi:10.1038/ncomms16032.","ama":"Simonnet J, Nassar M, Stella F, et al. Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. 2017;8. doi:10.1038/ncomms16032","apa":"Simonnet, J., Nassar, M., Stella, F., Cohen, I., Mathon, B., Boccara, C. N., … Fricker, D. (2017). Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms16032","ieee":"J. Simonnet et al., “Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum,” Nature Communications, vol. 8. Nature Publishing Group, 2017.","short":"J. Simonnet, M. Nassar, F. Stella, I. Cohen, B. Mathon, C.N. Boccara, R. Miles, D. Fricker, Nature Communications 8 (2017)."},"title":"Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum","publist_id":"7305","author":[{"full_name":"Simonnet, Jean","last_name":"Simonnet","first_name":"Jean"},{"first_name":"Mérie","full_name":"Nassar, Mérie","last_name":"Nassar"},{"orcid":"0000-0001-9439-3148","full_name":"Stella, Federico","last_name":"Stella","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","first_name":"Federico"},{"last_name":"Cohen","full_name":"Cohen, Ivan","first_name":"Ivan"},{"last_name":"Mathon","full_name":"Mathon, Bertrand","first_name":"Bertrand"},{"id":"3FC06552-F248-11E8-B48F-1D18A9856A87","first_name":"Charlotte","last_name":"Boccara","orcid":"0000-0001-7237-5109","full_name":"Boccara, Charlotte"},{"last_name":"Miles","full_name":"Miles, Richard","first_name":"Richard"},{"last_name":"Fricker","full_name":"Fricker, Desdemona","first_name":"Desdemona"}],"oa_version":"Published Version","abstract":[{"text":"Orientation in space is represented in specialized brain circuits. Persistent head direction signals are transmitted from anterior thalamus to the presubiculum, but the identity of the presubicular target neurons, their connectivity and function in local microcircuits are unknown. Here, we examine how thalamic afferents recruit presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic interactions between these cells. Pyramidal neuron activation of Martinotti cells in superficial layers is strongly facilitating such that high-frequency head directional stimulation efficiently unmutes synaptic excitation. Martinotti-cell feedback plays a dual role: precisely timed spikes may not inhibit the firing of in-tune head direction cells, while exerting lateral inhibition. Autonomous attractor dynamics emerge from a modelled network implementing wiring motifs and timing sensitive synaptic interactions in the pyramidal - Martinotti-cell feedback loop. This inhibitory microcircuit is therefore tuned to refine and maintain head direction information in the presubiculum.","lang":"eng"}],"intvolume":" 8","month":"07","scopus_import":1,"language":[{"iso":"eng"}],"file":[{"creator":"system","file_size":2948357,"date_updated":"2020-07-14T12:46:36Z","file_name":"IST-2018-937-v1+1_2017_Stella_Activity_dependent.pdf","date_created":"2018-12-12T10:14:31Z","relation":"main_file","access_level":"open_access","content_type":"application/pdf","checksum":"76d8a2b72a58e56adb410ec37dfa7eee","file_id":"5083"}],"publication_status":"published","publication_identifier":{"issn":["20411723"]},"license":"https://creativecommons.org/licenses/by/4.0/","volume":8,"_id":"514","pubrep_id":"937","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","ddc":["571"],"date_updated":"2021-01-12T08:01:16Z","department":[{"_id":"JoCs"}],"file_date_updated":"2020-07-14T12:46:36Z"},{"project":[{"name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","grant_number":"281511","_id":"257A4776-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"external_id":{"isi":["000391743700044"]},"article_processing_charge":"No","author":[{"first_name":"Joseph","id":"426376DC-F248-11E8-B48F-1D18A9856A87","full_name":"O'Neill, Joseph","last_name":"O'Neill"},{"id":"3FC06552-F248-11E8-B48F-1D18A9856A87","first_name":"Charlotte","orcid":"0000-0001-7237-5109","full_name":"Boccara, Charlotte","last_name":"Boccara"},{"last_name":"Stella","orcid":"0000-0001-9439-3148","full_name":"Stella, Federico","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","first_name":"Federico"},{"first_name":"Philipp","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","last_name":"Schönenberger","full_name":"Schönenberger, Philipp"},{"first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L"}],"publist_id":"6226","title":"Superficial layers of the medial entorhinal cortex replay independently of the hippocampus","citation":{"ama":"O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. 2017;355(6321):184-188. doi:10.1126/science.aag2787","apa":"O’Neill, J., Boccara, C. N., Stella, F., Schönenberger, P., & Csicsvari, J. L. (2017). Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aag2787","short":"J. O’Neill, C.N. Boccara, F. Stella, P. Schönenberger, J.L. Csicsvari, Science 355 (2017) 184–188.","ieee":"J. O’Neill, C. N. Boccara, F. Stella, P. Schönenberger, and J. L. Csicsvari, “Superficial layers of the medial entorhinal cortex replay independently of the hippocampus,” Science, vol. 355, no. 6321. American Association for the Advancement of Science, pp. 184–188, 2017.","mla":"O’Neill, Joseph, et al. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” Science, vol. 355, no. 6321, American Association for the Advancement of Science, 2017, pp. 184–88, doi:10.1126/science.aag2787.","ista":"O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. 2017. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. 355(6321), 184–188.","chicago":"O’Neill, Joseph, Charlotte N. Boccara, Federico Stella, Philipp Schönenberger, and Jozsef L Csicsvari. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” Science. American Association for the Advancement of Science, 2017. https://doi.org/10.1126/science.aag2787."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"publisher":"American Association for the Advancement of Science","quality_controlled":"1","page":"184 - 188","date_created":"2018-12-11T11:50:19Z","date_published":"2017-01-13T00:00:00Z","doi":"10.1126/science.aag2787","year":"2017","has_accepted_license":"1","isi":1,"publication":"Science","day":"13","type":"journal_article","pubrep_id":"976","status":"public","_id":"1132","department":[{"_id":"JoCs"}],"file_date_updated":"2018-12-12T10:10:22Z","date_updated":"2023-09-20T11:30:35Z","ddc":["571"],"scopus_import":"1","intvolume":" 355","month":"01","abstract":[{"lang":"eng","text":"The hippocampus is thought to initiate systems-wide mnemonic processes through the reactivation of previously acquired spatial and episodic memory traces, which can recruit the entorhinal cortex as a first stage of memory redistribution to other brain areas. Hippocampal reactivation occurs during sharp wave-ripples, in which synchronous network firing encodes sequences of places.We investigated the coordination of this replay by recording assembly activity simultaneously in the CA1 region of the hippocampus and superficial layers of the medial entorhinal cortex. We found that entorhinal cell assemblies can replay trajectories independently of the hippocampus and sharp wave-ripples. This suggests that the hippocampus is not the sole initiator of spatial and episodic memory trace reactivation. Memory systems involved in these processes may include nonhierarchical, parallel components."}],"oa_version":"Submitted Version","ec_funded":1,"issue":"6321","volume":355,"publication_status":"published","publication_identifier":{"issn":["00368075"]},"language":[{"iso":"eng"}],"file":[{"file_id":"4809","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_name":"IST-2018-976-v1+1_2017Preprint_ONeill_Superficial_layers.pdf","date_created":"2018-12-12T10:10:22Z","creator":"system","file_size":3761201,"date_updated":"2018-12-12T10:10:22Z"}]},{"day":"01","language":[{"iso":"eng"}],"publication":"Hippocampus","publication_status":"published","year":"2015","doi":"10.1002/hipo.22407","issue":"7","date_published":"2015-07-01T00:00:00Z","volume":25,"date_created":"2018-12-11T11:54:29Z","page":"838 - 857","oa_version":"None","abstract":[{"lang":"eng","text":"The hippocampal region, comprising the hippocampal formation and the parahippocampal region, has been one of the most intensively studied parts of the brain for decades. Better understanding of its functional diversity and complexity has led to an increased demand for specificity in experimental procedures and manipulations. In view of the complex 3D structure of the hippocampal region, precisely positioned experimental approaches require a fine-grained architectural description that is available and readable to experimentalists lacking detailed anatomical experience. In this paper, we provide the first cyto- and chemoarchitectural description of the hippocampal formation and parahippocampal region in the rat at high resolution and in the three standard sectional planes: coronal, horizontal and sagittal. The atlas uses a series of adjacent sections stained for neurons and for a number of chemical marker substances, particularly parvalbumin and calbindin. All the borders defined in one plane have been cross-checked against their counterparts in the other two planes. The entire dataset will be made available as a web-based interactive application through the Rodent Brain WorkBench (http://www.rbwb.org) which, together with this paper, provides a unique atlas resource."}],"month":"07","intvolume":" 25","publisher":"Wiley","scopus_import":1,"quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T06:53:46Z","citation":{"chicago":"Boccara, Charlotte N., Lisa Kjønigsen, Ingvild Hammer, Jan Bjaalie, Trygve Leergaard, and Menno Witter. “A Three-Plane Architectonic Atlas of the Rat Hippocampal Region.” Hippocampus. Wiley, 2015. https://doi.org/10.1002/hipo.22407.","ista":"Boccara CN, Kjønigsen L, Hammer I, Bjaalie J, Leergaard T, Witter M. 2015. A three-plane architectonic atlas of the rat hippocampal region. Hippocampus. 25(7), 838–857.","mla":"Boccara, Charlotte N., et al. “A Three-Plane Architectonic Atlas of the Rat Hippocampal Region.” Hippocampus, vol. 25, no. 7, Wiley, 2015, pp. 838–57, doi:10.1002/hipo.22407.","ieee":"C. N. Boccara, L. Kjønigsen, I. Hammer, J. Bjaalie, T. Leergaard, and M. Witter, “A three-plane architectonic atlas of the rat hippocampal region,” Hippocampus, vol. 25, no. 7. Wiley, pp. 838–857, 2015.","short":"C.N. Boccara, L. Kjønigsen, I. Hammer, J. Bjaalie, T. Leergaard, M. Witter, Hippocampus 25 (2015) 838–857.","ama":"Boccara CN, Kjønigsen L, Hammer I, Bjaalie J, Leergaard T, Witter M. A three-plane architectonic atlas of the rat hippocampal region. Hippocampus. 2015;25(7):838-857. doi:10.1002/hipo.22407","apa":"Boccara, C. N., Kjønigsen, L., Hammer, I., Bjaalie, J., Leergaard, T., & Witter, M. (2015). A three-plane architectonic atlas of the rat hippocampal region. Hippocampus. Wiley. https://doi.org/10.1002/hipo.22407"},"title":"A three-plane architectonic atlas of the rat hippocampal region","department":[{"_id":"JoCs"}],"author":[{"last_name":"Boccara","orcid":"0000-0001-7237-5109","full_name":"Boccara, Charlotte","first_name":"Charlotte","id":"3FC06552-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kjønigsen","full_name":"Kjønigsen, Lisa","first_name":"Lisa"},{"full_name":"Hammer, Ingvild","last_name":"Hammer","first_name":"Ingvild"},{"last_name":"Bjaalie","full_name":"Bjaalie, Jan","first_name":"Jan"},{"full_name":"Leergaard, Trygve","last_name":"Leergaard","first_name":"Trygve"},{"first_name":"Menno","full_name":"Witter, Menno","last_name":"Witter"}],"publist_id":"5222","_id":"1874","status":"public","type":"journal_article"}]