--- _id: '14314' abstract: - lang: eng text: The execution of cognitive functions requires coordinated circuit activity across different brain areas that involves the associated firing of neuronal assemblies. Here, we tested the circuit mechanism behind assembly interactions between the hippocampus and the medial prefrontal cortex (mPFC) of adult rats by recording neuronal populations during a rule-switching task. We identified functionally coupled CA1-mPFC cells that synchronized their activity beyond that expected from common spatial coding or oscillatory firing. When such cell pairs fired together, the mPFC cell strongly phase locked to CA1 theta oscillations and maintained consistent theta firing phases, independent of the theta timing of their CA1 counterpart. These functionally connected CA1-mPFC cells formed interconnected assemblies. While firing together with their CA1 assembly partners, mPFC cells fired along specific theta sequences. Our results suggest that upregulated theta oscillatory firing of mPFC cells can signal transient interactions with specific CA1 assemblies, thus enabling distributed computations. acknowledgement: We thank A. Cumpelik, H. Chiossi, and L. Bollman for comments on an earlier version of this manuscript. This work was funded by EU-FP7 MC-ITN IN-SENS (grant 607616). article_number: '113015' article_processing_charge: Yes article_type: original author: - first_name: Michele full_name: Nardin, Michele id: 30BD0376-F248-11E8-B48F-1D18A9856A87 last_name: Nardin orcid: 0000-0001-8849-6570 - first_name: Karola full_name: Käfer, Karola id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87 last_name: Käfer - first_name: Federico full_name: Stella, Federico id: 39AF1E74-F248-11E8-B48F-1D18A9856A87 last_name: Stella orcid: 0000-0001-9439-3148 - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Nardin M, Käfer K, Stella F, Csicsvari JL. Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions. Cell Reports. 2023;42(9). doi:10.1016/j.celrep.2023.113015 apa: Nardin, M., Käfer, K., Stella, F., & Csicsvari, J. L. (2023). Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2023.113015 chicago: Nardin, Michele, Karola Käfer, Federico Stella, and Jozsef L Csicsvari. “Theta Oscillations as a Substrate for Medial Prefrontal-Hippocampal Assembly Interactions.” Cell Reports. Elsevier, 2023. https://doi.org/10.1016/j.celrep.2023.113015. ieee: M. Nardin, K. Käfer, F. Stella, and J. L. Csicsvari, “Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions,” Cell Reports, vol. 42, no. 9. Elsevier, 2023. ista: Nardin M, Käfer K, Stella F, Csicsvari JL. 2023. Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions. Cell Reports. 42(9), 113015. mla: Nardin, Michele, et al. “Theta Oscillations as a Substrate for Medial Prefrontal-Hippocampal Assembly Interactions.” Cell Reports, vol. 42, no. 9, 113015, Elsevier, 2023, doi:10.1016/j.celrep.2023.113015. short: M. Nardin, K. Käfer, F. Stella, J.L. Csicsvari, Cell Reports 42 (2023). date_created: 2023-09-10T22:01:11Z date_published: 2023-09-26T00:00:00Z date_updated: 2023-09-15T07:14:12Z day: '26' ddc: - '570' department: - _id: JoCs doi: 10.1016/j.celrep.2023.113015 ec_funded: 1 external_id: pmid: - '37632747' file: - access_level: open_access checksum: ca77a304fb813c292550b8604b0fb41d content_type: application/pdf creator: dernst date_created: 2023-09-15T07:12:46Z date_updated: 2023-09-15T07:12:46Z file_id: '14337' file_name: 2023_CellPress_Nardin.pdf file_size: 4879455 relation: main_file success: 1 file_date_updated: 2023-09-15T07:12:46Z has_accepted_license: '1' intvolume: ' 42' issue: '9' language: - iso: eng month: '09' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 257BBB4C-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '607616' name: Inter-and intracellular signalling in schizophrenia publication: Cell Reports publication_identifier: eissn: - 2211-1247 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 42 year: '2023' ... --- _id: '14656' abstract: - lang: eng text: Although much is known about how single neurons in the hippocampus represent an animal's position, how circuit interactions contribute to spatial coding is less well understood. Using a novel statistical estimator and theoretical modeling, both developed in the framework of maximum entropy models, we reveal highly structured CA1 cell-cell interactions in male rats during open field exploration. The statistics of these interactions depend on whether the animal is in a familiar or novel environment. In both conditions the circuit interactions optimize the encoding of spatial information, but for regimes that differ in the informativeness of their spatial inputs. This structure facilitates linear decodability, making the information easy to read out by downstream circuits. Overall, our findings suggest that the efficient coding hypothesis is not only applicable to individual neuron properties in the sensory periphery, but also to neural interactions in the central brain. acknowledgement: M.N. was supported by the European Union Horizon 2020 Grant 665385. J.C. was supported by the European Research Council Consolidator Grant 281511. G.T. was supported by the Austrian Science Fund (FWF) Grant P34015. C.S. was supported by an Institute of Science and Technology fellow award and by the National Science Foundation (NSF) Award No. 1922658. We thank Peter Baracskay, Karola Kaefer, and Hugo Malagon-Vina for the acquisition of the data. We also thank Federico Stella, Wiktor Młynarski, Dori Derdikman, Colin Bredenberg, Roman Huszar, Heloisa Chiossi, Lorenzo Posani, and Mohamady El-Gaby for comments on an earlier version of the manuscript. article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Michele full_name: Nardin, Michele id: 30BD0376-F248-11E8-B48F-1D18A9856A87 last_name: Nardin orcid: 0000-0001-8849-6570 - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Gašper full_name: Tkačik, Gašper id: 3D494DCA-F248-11E8-B48F-1D18A9856A87 last_name: Tkačik orcid: 0000-0002-6699-1455 - first_name: Cristina full_name: Savin, Cristina id: 3933349E-F248-11E8-B48F-1D18A9856A87 last_name: Savin citation: ama: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1 interactions optimizes spatial coding across experience. The Journal of Neuroscience. 2023;43(48):8140-8156. doi:10.1523/JNEUROSCI.0194-23.2023 apa: Nardin, M., Csicsvari, J. L., Tkačik, G., & Savin, C. (2023). The structure of hippocampal CA1 interactions optimizes spatial coding across experience. The Journal of Neuroscience. Society of Neuroscience. https://doi.org/10.1523/JNEUROSCI.0194-23.2023 chicago: Nardin, Michele, Jozsef L Csicsvari, Gašper Tkačik, and Cristina Savin. “The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.” The Journal of Neuroscience. Society of Neuroscience, 2023. https://doi.org/10.1523/JNEUROSCI.0194-23.2023. ieee: M. Nardin, J. L. Csicsvari, G. Tkačik, and C. Savin, “The structure of hippocampal CA1 interactions optimizes spatial coding across experience,” The Journal of Neuroscience, vol. 43, no. 48. Society of Neuroscience, pp. 8140–8156, 2023. ista: Nardin M, Csicsvari JL, Tkačik G, Savin C. 2023. The structure of hippocampal CA1 interactions optimizes spatial coding across experience. The Journal of Neuroscience. 43(48), 8140–8156. mla: Nardin, Michele, et al. “The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.” The Journal of Neuroscience, vol. 43, no. 48, Society of Neuroscience, 2023, pp. 8140–56, doi:10.1523/JNEUROSCI.0194-23.2023. short: M. Nardin, J.L. Csicsvari, G. Tkačik, C. Savin, The Journal of Neuroscience 43 (2023) 8140–8156. date_created: 2023-12-10T23:00:58Z date_published: 2023-11-29T00:00:00Z date_updated: 2023-12-11T11:37:20Z day: '29' ddc: - '570' department: - _id: JoCs - _id: GaTk doi: 10.1523/JNEUROSCI.0194-23.2023 ec_funded: 1 external_id: pmid: - '37758476' file: - access_level: closed checksum: e2503c8f84be1050e28f64320f1d5bd2 content_type: application/pdf creator: dernst date_created: 2023-12-11T11:30:37Z date_updated: 2023-12-11T11:30:37Z embargo: 2024-06-01 embargo_to: open_access file_id: '14674' file_name: 2023_JourNeuroscience_Nardin.pdf file_size: 2280632 relation: main_file file_date_updated: 2023-12-11T11:30:37Z has_accepted_license: '1' intvolume: ' 43' issue: '48' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1523/JNEUROSCI.0194-23.2023 month: '11' oa: 1 oa_version: Published Version page: 8140-8156 pmid: 1 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex - _id: 626c45b5-2b32-11ec-9570-e509828c1ba6 grant_number: P34015 name: Efficient coding with biophysical realism - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program publication: The Journal of Neuroscience publication_identifier: eissn: - 1529-2401 publication_status: published publisher: Society of Neuroscience quality_controlled: '1' scopus_import: '1' status: public title: The structure of hippocampal CA1 interactions optimizes spatial coding across experience tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 43 year: '2023' ... --- _id: '11951' abstract: - lang: eng text: The mammalian hippocampal formation (HF) plays a key role in several higher brain functions, such as spatial coding, learning and memory. Its simple circuit architecture is often viewed as a trisynaptic loop, processing input originating from the superficial layers of the entorhinal cortex (EC) and sending it back to its deeper layers. Here, we show that excitatory neurons in layer 6b of the mouse EC project to all sub-regions comprising the HF and receive input from the CA1, thalamus and claustrum. Furthermore, their output is characterized by unique slow-decaying excitatory postsynaptic currents capable of driving plateau-like potentials in their postsynaptic targets. Optogenetic inhibition of the EC-6b pathway affects spatial coding in CA1 pyramidal neurons, while cell ablation impairs not only acquisition of new spatial memories, but also degradation of previously acquired ones. Our results provide evidence of a functional role for cortical layer 6b neurons in the adult brain. acknowledged_ssus: - _id: Bio - _id: SSU acknowledgement: We thank F. Marr and A. Schlögl for technical assistance, E. Kralli-Beller for manuscript editing, as well as C. Sommer and the Imaging and Optics Facility of the Institute of Science and Technology Austria (ISTA) for image analysis scripts and microscopy support. We extend our gratitude to J. Wallenschus and D. Rangel Guerrero for technical assistance acquiring single-unit data and I. Gridchyn for help with single-unit clustering. Finally, we also thank B. Suter for discussions, A. Saunders, M. Jösch, and H. Monyer for critically reading earlier versions of the manuscript, C. Petersen for sharing clearing protocols, and the Scientific Service Units of ISTA for efficient support. This project was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC advanced grant No 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award for P.J. and I3600-B27 for J.G.D. and P.V.). article_number: '4826' article_processing_charge: No article_type: original author: - first_name: Yoav full_name: Ben Simon, Yoav id: 43DF3136-F248-11E8-B48F-1D18A9856A87 last_name: Ben Simon - first_name: Karola full_name: Käfer, Karola id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87 last_name: Käfer - first_name: Philipp full_name: Velicky, Philipp id: 39BDC62C-F248-11E8-B48F-1D18A9856A87 last_name: Velicky orcid: 0000-0002-2340-7431 - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Ben Simon Y, Käfer K, Velicky P, Csicsvari JL, Danzl JG, Jonas PM. A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory. Nature Communications. 2022;13. doi:10.1038/s41467-022-32559-8 apa: Ben Simon, Y., Käfer, K., Velicky, P., Csicsvari, J. L., Danzl, J. G., & Jonas, P. M. (2022). A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-022-32559-8 chicago: Ben Simon, Yoav, Karola Käfer, Philipp Velicky, Jozsef L Csicsvari, Johann G Danzl, and Peter M Jonas. “A Direct Excitatory Projection from Entorhinal Layer 6b Neurons to the Hippocampus Contributes to Spatial Coding and Memory.” Nature Communications. Springer Nature, 2022. https://doi.org/10.1038/s41467-022-32559-8. ieee: Y. Ben Simon, K. Käfer, P. Velicky, J. L. Csicsvari, J. G. Danzl, and P. M. Jonas, “A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory,” Nature Communications, vol. 13. Springer Nature, 2022. ista: Ben Simon Y, Käfer K, Velicky P, Csicsvari JL, Danzl JG, Jonas PM. 2022. A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory. Nature Communications. 13, 4826. mla: Ben Simon, Yoav, et al. “A Direct Excitatory Projection from Entorhinal Layer 6b Neurons to the Hippocampus Contributes to Spatial Coding and Memory.” Nature Communications, vol. 13, 4826, Springer Nature, 2022, doi:10.1038/s41467-022-32559-8. short: Y. Ben Simon, K. Käfer, P. Velicky, J.L. Csicsvari, J.G. Danzl, P.M. Jonas, Nature Communications 13 (2022). date_created: 2022-08-24T08:25:50Z date_published: 2022-08-16T00:00:00Z date_updated: 2023-08-03T13:01:19Z day: '16' ddc: - '570' department: - _id: JoCs - _id: PeJo - _id: JoDa doi: 10.1038/s41467-022-32559-8 ec_funded: 1 external_id: isi: - '000841396400008' file: - access_level: open_access checksum: 405936d9e4d33625d80c093c9713a91f content_type: application/pdf creator: dernst date_created: 2022-08-26T11:51:40Z date_updated: 2022-08-26T11:51:40Z file_id: '11990' file_name: 2022_NatureCommunications_BenSimon.pdf file_size: 5910357 relation: main_file success: 1 file_date_updated: 2022-08-26T11:51:40Z has_accepted_license: '1' intvolume: ' 13' isi: 1 keyword: - General Physics and Astronomy - General Biochemistry - Genetics and Molecular Biology - General Chemistry - Multidisciplinary language: - iso: eng month: '08' oa: 1 oa_version: Published Version project: - _id: 25B7EB9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '692692' name: Biophysics and circuit function of a giant cortical glumatergic synapse - _id: 265CB4D0-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I03600 name: Optical control of synaptic function via adhesion molecules - _id: 25C5A090-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00312 name: The Wittgenstein Prize publication: Nature Communications publication_identifier: issn: - 2041-1723 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 13 year: '2022' ... --- _id: '10080' abstract: - lang: eng text: Hippocampal and neocortical neural activity is modulated by the position of the individual in space. While hippocampal neurons provide the basis for a spatial map, prefrontal cortical neurons generalize over environmental features. Whether these generalized representations result from a bidirectional interaction with, or are mainly derived from hippocampal spatial representations is not known. By examining simultaneously recorded hippocampal and medial prefrontal neurons, we observed that prefrontal spatial representations show a delayed coherence with hippocampal ones. We also identified subpopulations of cells in the hippocampus and medial prefrontal cortex that formed functional cross-area couplings; these resembled the optimal connections predicted by a probabilistic model of spatial information transfer and generalization. Moreover, cross-area couplings were strongest and had the shortest delay preceding spatial decision-making. Our results suggest that generalized spatial coding in the medial prefrontal cortex is inherited from spatial representations in the hippocampus, and that the routing of information can change dynamically with behavioral demands. acknowledgement: We thank Federico Stella for invaluable suggestions and discussions. We thank Yosman BapatDhar and Andrea Cumpelik for comments, help and suggestions on the exposure of the text. We thank Predrag Živadinović and Juliana Couras for comments on the text and the figures. This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616). article_processing_charge: No author: - first_name: Michele full_name: Nardin, Michele id: 30BD0376-F248-11E8-B48F-1D18A9856A87 last_name: Nardin orcid: 0000-0001-8849-6570 - first_name: Karola full_name: Käfer, Karola id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87 last_name: Käfer - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus. bioRxiv. doi:10.1101/2021.09.30.462269 apa: Nardin, M., Käfer, K., & Csicsvari, J. L. (n.d.). The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus. bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.09.30.462269 chicago: Nardin, Michele, Karola Käfer, and Jozsef L Csicsvari. “The Generalized Spatial Representation in the Prefrontal Cortex Is Inherited from the Hippocampus.” BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2021.09.30.462269. ieee: M. Nardin, K. Käfer, and J. L. Csicsvari, “The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus,” bioRxiv. Cold Spring Harbor Laboratory. ista: Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus. bioRxiv, 10.1101/2021.09.30.462269. mla: Nardin, Michele, et al. “The Generalized Spatial Representation in the Prefrontal Cortex Is Inherited from the Hippocampus.” BioRxiv, Cold Spring Harbor Laboratory, doi:10.1101/2021.09.30.462269. short: M. Nardin, K. Käfer, J.L. Csicsvari, BioRxiv (n.d.). date_created: 2021-10-04T06:28:32Z date_published: 2021-10-02T00:00:00Z date_updated: 2021-10-05T12:34:26Z day: '02' department: - _id: GradSch - _id: JoCs doi: 10.1101/2021.09.30.462269 ec_funded: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2021.09.30.462269 month: '10' oa: 1 oa_version: Preprint project: - _id: 257BBB4C-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '607616' name: Inter-and intracellular signalling in schizophrenia publication: bioRxiv publication_status: submitted publisher: Cold Spring Harbor Laboratory status: public title: The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus type: preprint user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2021' ... --- _id: '10077' abstract: - lang: eng text: Although much is known about how single neurons in the hippocampus represent an animal’s position, how cell-cell interactions contribute to spatial coding remains poorly understood. Using a novel statistical estimator and theoretical modeling, both developed in the framework of maximum entropy models, we reveal highly structured cell-to-cell interactions whose statistics depend on familiar vs. novel environment. In both conditions the circuit interactions optimize the encoding of spatial information, but for regimes that differ in the signal-to-noise ratio of their spatial inputs. Moreover, the topology of the interactions facilitates linear decodability, making the information easy to read out by downstream circuits. These findings suggest that the efficient coding hypothesis is not applicable only to individual neuron properties in the sensory periphery, but also to neural interactions in the central brain. acknowledgement: We thank Peter Baracskay, Karola Kaefer and Hugo Malagon-Vina for the acquisition of the data. We thank Federico Stella for comments on an earlier version of the manuscript. MN was supported by European Union Horizon 2020 grant 665385, JC was supported by European Research Council consolidator grant 281511, GT was supported by the Austrian Science Fund (FWF) grant P34015, CS was supported by an IST fellow grant, National Institute of Mental Health Award 1R01MH125571-01, by the National Science Foundation under NSF Award No. 1922658 and a Google faculty award. article_processing_charge: No author: - first_name: Michele full_name: Nardin, Michele id: 30BD0376-F248-11E8-B48F-1D18A9856A87 last_name: Nardin orcid: 0000-0001-8849-6570 - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Gašper full_name: Tkačik, Gašper id: 3D494DCA-F248-11E8-B48F-1D18A9856A87 last_name: Tkačik orcid: 0000-0002-6699-1455 - first_name: Cristina full_name: Savin, Cristina id: 3933349E-F248-11E8-B48F-1D18A9856A87 last_name: Savin citation: ama: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1 interactions optimizes spatial coding across experience. bioRxiv. doi:10.1101/2021.09.28.460602 apa: Nardin, M., Csicsvari, J. L., Tkačik, G., & Savin, C. (n.d.). The structure of hippocampal CA1 interactions optimizes spatial coding across experience. bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.09.28.460602 chicago: Nardin, Michele, Jozsef L Csicsvari, Gašper Tkačik, and Cristina Savin. “The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.” BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2021.09.28.460602. ieee: M. Nardin, J. L. Csicsvari, G. Tkačik, and C. Savin, “The structure of hippocampal CA1 interactions optimizes spatial coding across experience,” bioRxiv. Cold Spring Harbor Laboratory. ista: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1 interactions optimizes spatial coding across experience. bioRxiv, 10.1101/2021.09.28.460602. mla: Nardin, Michele, et al. “The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.” BioRxiv, Cold Spring Harbor Laboratory, doi:10.1101/2021.09.28.460602. short: M. Nardin, J.L. Csicsvari, G. Tkačik, C. Savin, BioRxiv (n.d.). date_created: 2021-10-04T06:23:34Z date_published: 2021-09-29T00:00:00Z date_updated: 2024-03-28T23:30:16Z day: '29' department: - _id: GradSch - _id: JoCs - _id: GaTk doi: 10.1101/2021.09.28.460602 ec_funded: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2021.09.28.460602 month: '09' oa: 1 oa_version: Preprint project: - _id: 25681D80-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '291734' name: International IST Postdoc Fellowship Programme - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex - _id: 626c45b5-2b32-11ec-9570-e509828c1ba6 grant_number: P34015 name: Efficient coding with biophysical realism publication: bioRxiv publication_status: submitted publisher: Cold Spring Harbor Laboratory related_material: record: - id: '11932' relation: dissertation_contains status: public status: public title: The structure of hippocampal CA1 interactions optimizes spatial coding across experience tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: preprint user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2021' ... --- _id: '7472' abstract: - lang: eng text: Temporally organized reactivation of experiences during awake immobility periods is thought to underlie cognitive processes like planning and evaluation. While replay of trajectories is well established for the hippocampus, it is unclear whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral experiences in the awake state to support task execution. We simultaneously recorded from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent rule-switching task on a plus maze. We found that mPFC neuronal activity encoded relative positions between the start and goal. During awake immobility periods, the mPFC replayed temporally organized sequences of these generalized positions, resembling entire spatial trajectories. The occurrence of mPFC trajectory replay positively correlated with rule-switching performance. However, hippocampal and mPFC trajectory replay occurred independently, indicating different functions. These results demonstrate that the mPFC can replay ordered activity patterns representing generalized locations and suggest that mPFC replay might have a role in flexible behavior. acknowledged_ssus: - _id: M-Shop acknowledgement: We thank Todor Asenov and Thomas Menner from the Machine Shop for the drive design and production, Hugo Malagon-Vina for assistance in maze automatization, Jago Wallenschus for taking the images of the histology, and Federico Stella and Juan Felipe Ramirez-Villegas for comments on an earlier version of the manuscript. This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616 ). article_processing_charge: No article_type: original author: - first_name: Karola full_name: Käfer, Karola id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87 last_name: Käfer - first_name: Michele full_name: Nardin, Michele id: 30BD0376-F248-11E8-B48F-1D18A9856A87 last_name: Nardin orcid: 0000-0001-8849-6570 - first_name: Karel full_name: Blahna, Karel id: 3EA859AE-F248-11E8-B48F-1D18A9856A87 last_name: Blahna - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Käfer K, Nardin M, Blahna K, Csicsvari JL. Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. 2020;106(1):P154-165.e6. doi:10.1016/j.neuron.2020.01.015 apa: Käfer, K., Nardin, M., Blahna, K., & Csicsvari, J. L. (2020). Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.01.015 chicago: Käfer, Karola, Michele Nardin, Karel Blahna, and Jozsef L Csicsvari. “Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.015. ieee: K. Käfer, M. Nardin, K. Blahna, and J. L. Csicsvari, “Replay of behavioral sequences in the medial prefrontal cortex during rule switching,” Neuron, vol. 106, no. 1. Elsevier, p. P154–165.e6, 2020. ista: Käfer K, Nardin M, Blahna K, Csicsvari JL. 2020. Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. 106(1), P154–165.e6. mla: Käfer, Karola, et al. “Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.” Neuron, vol. 106, no. 1, Elsevier, 2020, p. P154–165.e6, doi:10.1016/j.neuron.2020.01.015. short: K. Käfer, M. Nardin, K. Blahna, J.L. Csicsvari, Neuron 106 (2020) P154–165.e6. date_created: 2020-02-10T15:45:48Z date_published: 2020-04-08T00:00:00Z date_updated: 2023-08-17T14:38:02Z day: '08' department: - _id: JoCs doi: 10.1016/j.neuron.2020.01.015 ec_funded: 1 external_id: isi: - '000525319300016' pmid: - '32032512' intvolume: ' 106' isi: 1 issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.neuron.2020.01.015 month: '04' oa: 1 oa_version: Published Version page: P154-165.e6 pmid: 1 project: - _id: 257BBB4C-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '607616' name: Inter-and intracellular signalling in schizophrenia publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier quality_controlled: '1' related_material: link: - description: News on IST Homepage relation: press_release url: https://ist.ac.at/en/news/this-brain-area-helps-us-decide/ scopus_import: '1' status: public title: Replay of behavioral sequences in the medial prefrontal cortex during rule switching type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 106 year: '2020' ... --- _id: '7684' article_processing_charge: No article_type: original author: - first_name: Igor full_name: Gridchyn, Igor id: 4B60654C-F248-11E8-B48F-1D18A9856A87 last_name: Gridchyn orcid: 0000-0002-1807-1929 - first_name: Philipp full_name: Schönenberger, Philipp id: 3B9D816C-F248-11E8-B48F-1D18A9856A87 last_name: Schönenberger - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Assembly-specific disruption of hippocampal replay leads to selective memory deficit. Neuron. 2020;106(2):291-300.e6. doi:10.1016/j.neuron.2020.01.021 apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020). Assembly-specific disruption of hippocampal replay leads to selective memory deficit. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.01.021 chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari. “Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory Deficit.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.021. ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Assembly-specific disruption of hippocampal replay leads to selective memory deficit,” Neuron, vol. 106, no. 2. Elsevier, p. 291–300.e6, 2020. ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Assembly-specific disruption of hippocampal replay leads to selective memory deficit. Neuron. 106(2), 291–300.e6. mla: Gridchyn, Igor, et al. “Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory Deficit.” Neuron, vol. 106, no. 2, Elsevier, 2020, p. 291–300.e6, doi:10.1016/j.neuron.2020.01.021. short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, Neuron 106 (2020) 291–300.e6. date_created: 2020-04-26T22:00:45Z date_published: 2020-04-22T00:00:00Z date_updated: 2023-08-21T06:15:31Z day: '22' department: - _id: JoCs doi: 10.1016/j.neuron.2020.01.021 ec_funded: 1 external_id: isi: - '000528268200013' pmid: - '32070475' intvolume: ' 106' isi: 1 issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.neuron.2020.01.021 month: '04' oa: 1 oa_version: Published Version page: 291-300.e6 pmid: 1 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex publication: Neuron publication_identifier: eissn: - '10974199' issn: - '08966273' publication_status: published publisher: Elsevier quality_controlled: '1' related_material: link: - description: News on IST Homepage relation: press_release url: https://ist.ac.at/en/news/librarian-of-memory/ scopus_import: '1' status: public title: Assembly-specific disruption of hippocampal replay leads to selective memory deficit type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 106 year: '2020' ... --- _id: '8740' abstract: - lang: eng text: In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity. Both behavioral and learning-dependent reorganization of these connections has also been demonstrated by measuring spike transmission probabilities in pyramidal cell-interneuron spike cross-correlations that indicate monosynaptic connections. Here we investigated the activity-dependent modification of these connections during exploratory behavior in rats by optogenetically inhibiting pyramidal cell and interneuron subpopulations. Light application and associated firing alteration of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron connection weights as indicated by spike transmission changes. Spike transmission alterations were predicted by the light-mediated changes in the number of pre- and postsynaptic spike pairing events and by firing rate changes of interneurons but not pyramidal cells. This work demonstrates the presence of activity-dependent associative and non-associative reorganization of pyramidal-interneuron connections triggered by the optogenetic modification of the firing rate and spike synchrony of cells. acknowledgement: We thank Michele Nardin and Federico Stella for comments on an earlier version of the manuscript. K Deisseroth for providing the pAAV-CaMKIIα::eNpHR3.0-YFP plasmid through Addgene. E Boyden for providing AAV2/1.CaMKII::ArchT.GFP.WPRE.SV40 plasmid through Penn Vector Core. This work was supported by the Austrian Science Fund (I02072 and I03713) and a Swiss National Science Foundation grant to PS. The authors declare no conflicts of interest. article_number: '61106' article_processing_charge: No article_type: original author: - first_name: Igor full_name: Gridchyn, Igor id: 4B60654C-F248-11E8-B48F-1D18A9856A87 last_name: Gridchyn orcid: 0000-0002-1807-1929 - first_name: Philipp full_name: Schönenberger, Philipp id: 3B9D816C-F248-11E8-B48F-1D18A9856A87 last_name: Schönenberger - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. eLife. 2020;9. doi:10.7554/eLife.61106 apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020). Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.61106 chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari. “Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” ELife. eLife Sciences Publications, 2020. https://doi.org/10.7554/eLife.61106. ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior,” eLife, vol. 9. eLife Sciences Publications, 2020. ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. eLife. 9, 61106. mla: Gridchyn, Igor, et al. “Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” ELife, vol. 9, 61106, eLife Sciences Publications, 2020, doi:10.7554/eLife.61106. short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, ELife 9 (2020). date_created: 2020-11-08T23:01:25Z date_published: 2020-10-05T00:00:00Z date_updated: 2024-02-21T12:43:40Z day: '05' ddc: - '570' department: - _id: JoCs doi: 10.7554/eLife.61106 external_id: isi: - '000584369000001' file: - access_level: open_access checksum: 6a7b0543c440f4c000a1864e69377d95 content_type: application/pdf creator: dernst date_created: 2020-11-09T09:17:40Z date_updated: 2020-11-09T09:17:40Z file_id: '8749' file_name: 2020_eLife_Gridchyn.pdf file_size: 447669 relation: main_file success: 1 file_date_updated: 2020-11-09T09:17:40Z has_accepted_license: '1' intvolume: ' 9' isi: 1 language: - iso: eng month: '10' oa: 1 oa_version: Published Version project: - _id: 257D4372-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I2072-B27 name: Interneuron plasticity during spatial learning - _id: 2654F984-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I03713 name: Interneuro Plasticity During Spatial Learning publication: eLife publication_identifier: eissn: - 2050084X publication_status: published publisher: eLife Sciences Publications quality_controlled: '1' related_material: record: - id: '8563' relation: research_data status: public scopus_import: '1' status: public title: Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 9 year: '2020' ... --- _id: '8563' abstract: - lang: eng text: "Supplementary data provided for the provided for the publication:\r\nIgor Gridchyn , Philipp Schoenenberger , Joseph O'Neill , Jozsef Csicsvari (2020) Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. Elife." article_processing_charge: No author: - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Igor full_name: Gridchyn, Igor id: 4B60654C-F248-11E8-B48F-1D18A9856A87 last_name: Gridchyn orcid: 0000-0002-1807-1929 - first_name: Philipp full_name: Schönenberger, Philipp id: 3B9D816C-F248-11E8-B48F-1D18A9856A87 last_name: Schönenberger citation: ama: Csicsvari JL, Gridchyn I, Schönenberger P. Optogenetic alteration of hippocampal network activity. 2020. doi:10.15479/AT:ISTA:8563 apa: Csicsvari, J. L., Gridchyn, I., & Schönenberger, P. (2020). Optogenetic alteration of hippocampal network activity. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8563 chicago: Csicsvari, Jozsef L, Igor Gridchyn, and Philipp Schönenberger. “Optogenetic Alteration of Hippocampal Network Activity.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8563. ieee: J. L. Csicsvari, I. Gridchyn, and P. Schönenberger, “Optogenetic alteration of hippocampal network activity.” Institute of Science and Technology Austria, 2020. ista: Csicsvari JL, Gridchyn I, Schönenberger P. 2020. Optogenetic alteration of hippocampal network activity, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8563. mla: Csicsvari, Jozsef L., et al. Optogenetic Alteration of Hippocampal Network Activity. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8563. short: J.L. Csicsvari, I. Gridchyn, P. Schönenberger, (2020). contributor: - contributor_type: project_leader first_name: Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 date_created: 2020-09-23T14:39:54Z date_published: 2020-10-19T00:00:00Z date_updated: 2024-02-21T12:43:41Z day: '19' ddc: - '570' department: - _id: JoCs doi: 10.15479/AT:ISTA:8563 file: - access_level: open_access checksum: a16098a6d172f9c42ab5af5f6991668c content_type: application/x-compressed creator: jozsef date_created: 2020-09-23T14:36:17Z date_updated: 2020-09-23T14:36:17Z file_id: '8564' file_name: upload.tgz file_size: 145243906 relation: main_file success: 1 - access_level: open_access checksum: 0bfc54b7e14c0694cd081617318ba606 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: jozsef date_created: 2020-10-19T10:12:29Z date_updated: 2020-10-19T10:12:29Z file_id: '8675' file_name: redme.docx file_size: 11648 relation: main_file success: 1 file_date_updated: 2020-10-19T10:12:29Z has_accepted_license: '1' month: '10' oa: 1 oa_version: Published Version publisher: Institute of Science and Technology Austria related_material: record: - id: '8740' relation: used_in_publication status: public status: public title: Optogenetic alteration of hippocampal network activity tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: research_data user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2020' ... --- _id: '6338' abstract: - lang: eng text: Hippocampal activity patterns representing movement trajectories are reactivated in immobility and sleep periods, a process associated with memory recall, consolidation, and decision making. It is thought that only fixed, behaviorally relevant patterns can be reactivated, which are stored across hippocampal synaptic connections. To test whether some generalized rules govern reactivation, we examined trajectory reactivation following non-stereotypical exploration of familiar open-field environments. We found that random trajectories of varying lengths and timescales were reactivated, resembling that of Brownian motion of particles. The animals’ behavioral trajectory did not follow Brownian diffusion demonstrating that the exact behavioral experience is not reactivated. Therefore, hippocampal circuits are able to generate random trajectories of any recently active map by following diffusion dynamics. This ability of hippocampal circuits to generate representations of all behavioral outcome combinations, experienced or not, may underlie a wide variety of hippocampal-dependent cognitive functions such as learning, generalization, and planning. article_processing_charge: No article_type: original author: - first_name: Federico full_name: Stella, Federico id: 39AF1E74-F248-11E8-B48F-1D18A9856A87 last_name: Stella orcid: 0000-0001-9439-3148 - first_name: Peter full_name: Baracskay, Peter id: 361CC00E-F248-11E8-B48F-1D18A9856A87 last_name: Baracskay - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Stella F, Baracskay P, O’Neill J, Csicsvari JL. Hippocampal reactivation of random trajectories resembling Brownian diffusion. Neuron. 2019;102:450-461. doi:10.1016/j.neuron.2019.01.052 apa: Stella, F., Baracskay, P., O’Neill, J., & Csicsvari, J. L. (2019). Hippocampal reactivation of random trajectories resembling Brownian diffusion. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2019.01.052 chicago: Stella, Federico, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari. “Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.01.052. ieee: F. Stella, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Hippocampal reactivation of random trajectories resembling Brownian diffusion,” Neuron, vol. 102. Elsevier, pp. 450–461, 2019. ista: Stella F, Baracskay P, O’Neill J, Csicsvari JL. 2019. Hippocampal reactivation of random trajectories resembling Brownian diffusion. Neuron. 102, 450–461. mla: Stella, Federico, et al. “Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.” Neuron, vol. 102, Elsevier, 2019, pp. 450–61, doi:10.1016/j.neuron.2019.01.052. short: F. Stella, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 102 (2019) 450–461. date_created: 2019-04-17T08:28:59Z date_published: 2019-04-17T00:00:00Z date_updated: 2023-08-25T10:13:07Z day: '17' department: - _id: JoCs doi: 10.1016/j.neuron.2019.01.052 ec_funded: 1 external_id: isi: - '000465169700017' pmid: - '30819547' intvolume: ' 102' isi: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.neuron.2019.01.052 month: '04' oa: 1 oa_version: Published Version page: 450-461 pmid: 1 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex - _id: 2654F984-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I03713 name: Interneuro Plasticity During Spatial Learning publication: Neuron publication_status: published publisher: Elsevier quality_controlled: '1' related_material: link: - description: News on IST Homepage relation: press_release url: https://ist.ac.at/en/news/memories-of-movement-are-replayed-randomly-during-sleep/ scopus_import: '1' status: public title: Hippocampal reactivation of random trajectories resembling Brownian diffusion type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 102 year: '2019' ... --- _id: '5828' abstract: - lang: eng text: Hippocampus is needed for both spatial working and reference memories. Here, using a radial eight-arm maze, we examined how the combined demand on these memories influenced CA1 place cell assemblies while reference memories were partially updated. This was contrasted with control tasks requiring only working memory or the update of reference memory. Reference memory update led to the reward-directed place field shifts at newly rewarded arms and to the gradual strengthening of firing in passes between newly rewarded arms but not between those passes that included a familiar-rewarded arm. At the maze center, transient network synchronization periods preferentially replayed trajectories of the next chosen arm in reference memory tasks but the previously visited arm in the working memory task. Hence, reference memory demand was uniquely associated with a gradual, goal novelty-related reorganization of place cell assemblies and with trajectory replay that reflected the animal's decision of which arm to visit next. article_processing_charge: No article_type: original author: - first_name: Haibing full_name: Xu, Haibing id: 310349D0-F248-11E8-B48F-1D18A9856A87 last_name: Xu - first_name: Peter full_name: Baracskay, Peter id: 361CC00E-F248-11E8-B48F-1D18A9856A87 last_name: Baracskay - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Xu H, Baracskay P, O’Neill J, Csicsvari JL. Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze. Neuron. 2019;101(1):119-132.e4. doi:10.1016/j.neuron.2018.11.015 apa: Xu, H., Baracskay, P., O’Neill, J., & Csicsvari, J. L. (2019). Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2018.11.015 chicago: Xu, Haibing, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari. “Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2018.11.015. ieee: H. Xu, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze,” Neuron, vol. 101, no. 1. Elsevier, p. 119–132.e4, 2019. ista: Xu H, Baracskay P, O’Neill J, Csicsvari JL. 2019. Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze. Neuron. 101(1), 119–132.e4. mla: Xu, Haibing, et al. “Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze.” Neuron, vol. 101, no. 1, Elsevier, 2019, p. 119–132.e4, doi:10.1016/j.neuron.2018.11.015. short: H. Xu, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 101 (2019) 119–132.e4. date_created: 2019-01-13T22:59:10Z date_published: 2019-01-02T00:00:00Z date_updated: 2023-09-07T12:06:37Z day: '02' department: - _id: JoCs doi: 10.1016/j.neuron.2018.11.015 ec_funded: 1 external_id: isi: - '000454791500014' intvolume: ' 101' isi: 1 issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://www.doi.org/10.1016/j.neuron.2018.11.015 month: '01' oa: 1 oa_version: Published Version page: 119-132.e4 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex publication: Neuron publication_identifier: issn: - '10974199' publication_status: published publisher: Elsevier quality_controlled: '1' related_material: link: - description: News on IST Homepage relation: press_release url: https://ist.ac.at/en/news/reading-rats-minds/ record: - id: '837' relation: dissertation_contains status: public scopus_import: '1' status: public title: Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 101 year: '2019' ... --- _id: '6194' abstract: - lang: eng text: Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric to the hippocampal cognitive map, yet environmental geometrical features have recently been shown to distort the grid structure. Given that the hippocampal role goes beyond space, we tested the influence of nonspatial information on the grid organization. We trained rats to daily learn three new reward locations on a cheeseboard maze while recording from the medial entorhinal cortex and the hippocampal CA1 region. Many grid fields moved toward goal location, leading to long-lasting deformations of the entorhinal map. Therefore, distortions in the grid structure contribute to goal representation during both learning and recall, which demonstrates that grid cells participate in mnemonic coding and do not merely provide a simple metric of space. article_processing_charge: No article_type: original author: - first_name: Charlotte N. full_name: Boccara, Charlotte N. id: 3FC06552-F248-11E8-B48F-1D18A9856A87 last_name: Boccara orcid: 0000-0001-7237-5109 - first_name: Michele full_name: Nardin, Michele id: 30BD0376-F248-11E8-B48F-1D18A9856A87 last_name: Nardin orcid: 0000-0001-8849-6570 - first_name: Federico full_name: Stella, Federico id: 39AF1E74-F248-11E8-B48F-1D18A9856A87 last_name: Stella orcid: 0000-0001-9439-3148 - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. The entorhinal cognitive map is attracted to goals. Science. 2019;363(6434):1443-1447. doi:10.1126/science.aav4837 apa: Boccara, C. N., Nardin, M., Stella, F., O’Neill, J., & Csicsvari, J. L. (2019). The entorhinal cognitive map is attracted to goals. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aav4837 chicago: Boccara, Charlotte N., Michele Nardin, Federico Stella, Joseph O’Neill, and Jozsef L Csicsvari. “The Entorhinal Cognitive Map Is Attracted to Goals.” Science. American Association for the Advancement of Science, 2019. https://doi.org/10.1126/science.aav4837. ieee: C. N. Boccara, M. Nardin, F. Stella, J. O’Neill, and J. L. Csicsvari, “The entorhinal cognitive map is attracted to goals,” Science, vol. 363, no. 6434. American Association for the Advancement of Science, pp. 1443–1447, 2019. ista: Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. 2019. The entorhinal cognitive map is attracted to goals. Science. 363(6434), 1443–1447. mla: Boccara, Charlotte N., et al. “The Entorhinal Cognitive Map Is Attracted to Goals.” Science, vol. 363, no. 6434, American Association for the Advancement of Science, 2019, pp. 1443–47, doi:10.1126/science.aav4837. short: C.N. Boccara, M. Nardin, F. Stella, J. O’Neill, J.L. Csicsvari, Science 363 (2019) 1443–1447. date_created: 2019-04-04T08:39:30Z date_published: 2019-03-29T00:00:00Z date_updated: 2024-03-28T23:30:16Z day: '29' ddc: - '570' department: - _id: JoCs doi: 10.1126/science.aav4837 ec_funded: 1 external_id: isi: - '000462738000034' file: - access_level: open_access checksum: 5e6b16742cde10a560cfaf2130764da1 content_type: application/pdf creator: dernst date_created: 2020-05-14T09:11:10Z date_updated: 2020-07-14T12:47:23Z file_id: '7826' file_name: 2019_Science_Boccara.pdf file_size: 9045923 relation: main_file file_date_updated: 2020-07-14T12:47:23Z has_accepted_license: '1' intvolume: ' 363' isi: 1 issue: '6434' language: - iso: eng month: '03' oa: 1 oa_version: Submitted Version page: 1443-1447 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' related_material: link: - description: News on IST Homepage relation: press_release url: https://ist.ac.at/en/news/grid-cells-create-treasure-map-in-rat-brain/ record: - id: '6062' relation: popular_science status: public - id: '11932' relation: dissertation_contains status: public scopus_import: '1' status: public title: The entorhinal cognitive map is attracted to goals type: journal_article user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 volume: 363 year: '2019' ... --- _id: '5949' abstract: - lang: eng text: Aberrant proteostasis of protein aggregation may lead to behavior disorders including chronic mental illnesses (CMI). Furthermore, the neuronal activity alterations that underlie CMI are not well understood. We recorded the local field potential and single-unit activity of the hippocampal CA1 region in vivo in rats transgenically overexpressing the Disrupted-in-Schizophrenia 1 (DISC1) gene (tgDISC1), modeling sporadic CMI. These tgDISC1 rats have previously been shown to exhibit DISC1 protein aggregation, disturbances in the dopaminergic system and attention-related deficits. Recordings were performed during exploration of familiar and novel open field environments and during sleep, allowing investigation of neuronal abnormalities in unconstrained behavior. Compared to controls, tgDISC1 place cells exhibited smaller place fields and decreased speed-modulation of their firing rates, demonstrating altered spatial coding and deficits in encoding location-independent sensory inputs. Oscillation analyses showed that tgDISC1 pyramidal neurons had higher theta phase locking strength during novelty, limiting their phase coding ability. However, their mean theta phases were more variable at the population level, reducing oscillatory network synchronization. Finally, tgDISC1 pyramidal neurons showed a lack of novelty-induced shift in their preferred theta and gamma firing phases, indicating deficits in coding of novel environments with oscillatory firing. By combining single cell and neuronal population analyses, we link DISC1 protein pathology with abnormal hippocampal neural coding and network synchrony, and thereby gain a more comprehensive understanding of CMI mechanisms. article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Karola full_name: Käfer, Karola id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87 last_name: Käfer - first_name: Hugo full_name: Malagon-Vina, Hugo last_name: Malagon-Vina - first_name: Desiree full_name: Dickerson, Desiree id: 444EB89E-F248-11E8-B48F-1D18A9856A87 last_name: Dickerson - first_name: Joseph full_name: O'Neill, Joseph last_name: O'Neill - first_name: Svenja V. full_name: Trossbach, Svenja V. last_name: Trossbach - first_name: Carsten full_name: Korth, Carsten last_name: Korth - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Käfer K, Malagon-Vina H, Dickerson D, et al. Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization. Hippocampus. 2019;29(9):802-816. doi:10.1002/hipo.23076 apa: Käfer, K., Malagon-Vina, H., Dickerson, D., O’Neill, J., Trossbach, S. V., Korth, C., & Csicsvari, J. L. (2019). Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization. Hippocampus. Wiley. https://doi.org/10.1002/hipo.23076 chicago: Käfer, Karola, Hugo Malagon-Vina, Desiree Dickerson, Joseph O’Neill, Svenja V. Trossbach, Carsten Korth, and Jozsef L Csicsvari. “Disrupted-in-Schizophrenia 1 Overexpression Disrupts Hippocampal Coding and Oscillatory Synchronization.” Hippocampus. Wiley, 2019. https://doi.org/10.1002/hipo.23076. ieee: K. Käfer et al., “Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization,” Hippocampus, vol. 29, no. 9. Wiley, pp. 802–816, 2019. ista: Käfer K, Malagon-Vina H, Dickerson D, O’Neill J, Trossbach SV, Korth C, Csicsvari JL. 2019. Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization. Hippocampus. 29(9), 802–816. mla: Käfer, Karola, et al. “Disrupted-in-Schizophrenia 1 Overexpression Disrupts Hippocampal Coding and Oscillatory Synchronization.” Hippocampus, vol. 29, no. 9, Wiley, 2019, pp. 802–16, doi:10.1002/hipo.23076. short: K. Käfer, H. Malagon-Vina, D. Dickerson, J. O’Neill, S.V. Trossbach, C. Korth, J.L. Csicsvari, Hippocampus 29 (2019) 802–816. date_created: 2019-02-10T22:59:18Z date_published: 2019-09-01T00:00:00Z date_updated: 2024-03-28T23:30:22Z day: '01' ddc: - '570' department: - _id: JoCs doi: 10.1002/hipo.23076 ec_funded: 1 external_id: isi: - '000480635400003' file: - access_level: open_access checksum: 5e8de271ca04aef92a5de42d6aac4404 content_type: application/pdf creator: dernst date_created: 2019-02-11T10:42:51Z date_updated: 2020-07-14T12:47:13Z file_id: '5950' file_name: 2019_Hippocampus_Kaefer.pdf file_size: 2132893 relation: main_file file_date_updated: 2020-07-14T12:47:13Z has_accepted_license: '1' intvolume: ' 29' isi: 1 issue: '9' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: 802-816 project: - _id: 257BBB4C-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '607616' name: Inter-and intracellular signalling in schizophrenia publication: Hippocampus publication_status: published publisher: Wiley quality_controlled: '1' related_material: record: - id: '6825' relation: dissertation_contains status: public scopus_import: '1' status: public title: Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 29 year: '2019' ... --- _id: '5914' abstract: - lang: eng text: With the advent of optogenetics, it became possible to change the activity of a targeted population of neurons in a temporally controlled manner. To combine the advantages of 60-channel in vivo tetrode recording and laser-based optogenetics, we have developed a closed-loop recording system that allows for the actual electrophysiological signal to be used as a trigger for the laser light mediating the optogenetic intervention. We have optimized the weight, size, and shape of the corresponding implant to make it compatible with the size, force, and movements of a behaving mouse, and we have shown that the system can efficiently block sharp wave ripple (SWR) events using those events themselves as a trigger. To demonstrate the full potential of the optogenetic recording system we present a pilot study addressing the contribution of SWR events to learning in a complex behavioral task. article_number: e0087 article_processing_charge: No author: - first_name: Dámaris K full_name: Rangel Guerrero, Dámaris K id: 4871BCE6-F248-11E8-B48F-1D18A9856A87 last_name: Rangel Guerrero orcid: 0000-0002-8602-4374 - first_name: James G. full_name: Donnett, James G. last_name: Donnett - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Krisztián full_name: Kovács, Krisztián id: 2AB5821E-F248-11E8-B48F-1D18A9856A87 last_name: Kovács orcid: 0000-0001-6251-1007 citation: ama: 'Rangel Guerrero DK, Donnett JG, Csicsvari JL, Kovács K. Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning. eNeuro. 2018;5(4). doi:10.1523/ENEURO.0087-18.2018' apa: 'Rangel Guerrero, D. K., Donnett, J. G., Csicsvari, J. L., & Kovács, K. (2018). Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning. ENeuro. Society of Neuroscience. https://doi.org/10.1523/ENEURO.0087-18.2018' chicago: 'Rangel Guerrero, Dámaris K, James G. Donnett, Jozsef L Csicsvari, and Krisztián Kovács. “Tetrode Recording from the Hippocampus of Behaving Mice Coupled with Four-Point-Irradiation Closed-Loop Optogenetics: A Technique to Study the Contribution of Hippocampal SWR Events to Learning.” ENeuro. Society of Neuroscience, 2018. https://doi.org/10.1523/ENEURO.0087-18.2018.' ieee: 'D. K. Rangel Guerrero, J. G. Donnett, J. L. Csicsvari, and K. Kovács, “Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning,” eNeuro, vol. 5, no. 4. Society of Neuroscience, 2018.' ista: 'Rangel Guerrero DK, Donnett JG, Csicsvari JL, Kovács K. 2018. Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning. eNeuro. 5(4), e0087.' mla: 'Rangel Guerrero, Dámaris K., et al. “Tetrode Recording from the Hippocampus of Behaving Mice Coupled with Four-Point-Irradiation Closed-Loop Optogenetics: A Technique to Study the Contribution of Hippocampal SWR Events to Learning.” ENeuro, vol. 5, no. 4, e0087, Society of Neuroscience, 2018, doi:10.1523/ENEURO.0087-18.2018.' short: D.K. Rangel Guerrero, J.G. Donnett, J.L. Csicsvari, K. Kovács, ENeuro 5 (2018). date_created: 2019-02-03T22:59:16Z date_published: 2018-07-27T00:00:00Z date_updated: 2024-03-28T23:30:10Z day: '27' ddc: - '570' department: - _id: JoCs doi: 10.1523/ENEURO.0087-18.2018 ec_funded: 1 external_id: isi: - '000443994700007' file: - access_level: open_access checksum: f4915d45fc7ad4648b7b7a13fdecca01 content_type: application/pdf creator: dernst date_created: 2019-02-05T12:48:36Z date_updated: 2020-07-14T12:47:13Z file_id: '5921' file_name: 2018_ENeuro_Guerrero.pdf file_size: 3746884 relation: main_file file_date_updated: 2020-07-14T12:47:13Z has_accepted_license: '1' intvolume: ' 5' isi: 1 issue: '4' language: - iso: eng month: '07' oa: 1 oa_version: Published Version project: - _id: 25681D80-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '291734' name: International IST Postdoc Fellowship Programme - _id: 257D4372-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I2072-B27 name: Interneuron plasticity during spatial learning publication: eNeuro publication_status: published publisher: Society of Neuroscience quality_controlled: '1' related_material: record: - id: '6849' relation: dissertation_contains status: public scopus_import: '1' status: public title: 'Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 volume: 5 year: '2018' ... --- _id: '1118' abstract: - lang: eng text: Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation during non-rapid eye movement sleep, immobility, and consummatory behavior. However, whether temporally modulated synaptic excitation or inhibition underlies the ripples is controversial. To address this question, we performed simultaneous recordings of excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) and local field potentials (LFPs) in the CA1 region of awake mice in vivo. During SWRs, inhibition dominated over excitation, with a peak conductance ratio of 4.1 ± 0.5. Furthermore, the amplitude of SWR-associated IPSCs was positively correlated with SWR magnitude, whereas that of EPSCs was not. Finally, phase analysis indicated that IPSCs were phase-locked to individual ripple cycles, whereas EPSCs were uniformly distributed in phase space. Optogenetic inhibition indicated that PV+ interneurons provided a major contribution to SWR-associated IPSCs. Thus, phasic inhibition, but not excitation, shapes SWR oscillations in the hippocampal CA1 region in vivo. acknowledged_ssus: - _id: M-Shop - _id: ScienComp - _id: PreCl article_processing_charge: No author: - first_name: Jian full_name: Gan, Jian id: 3614E438-F248-11E8-B48F-1D18A9856A87 last_name: Gan - first_name: Shih-Ming full_name: Weng, Shih-Ming id: 2F9C5AC8-F248-11E8-B48F-1D18A9856A87 last_name: Weng - first_name: Alejandro full_name: Pernia-Andrade, Alejandro id: 36963E98-F248-11E8-B48F-1D18A9856A87 last_name: Pernia-Andrade - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. Neuron. 2017;93(2):308-314. doi:10.1016/j.neuron.2016.12.018 apa: Gan, J., Weng, S.-M., Pernia-Andrade, A., Csicsvari, J. L., & Jonas, P. M. (2017). Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2016.12.018 chicago: Gan, Jian, Shih-Ming Weng, Alejandro Pernia-Andrade, Jozsef L Csicsvari, and Peter M Jonas. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice in Vivo.” Neuron. Elsevier, 2017. https://doi.org/10.1016/j.neuron.2016.12.018. ieee: J. Gan, S.-M. Weng, A. Pernia-Andrade, J. L. Csicsvari, and P. M. Jonas, “Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo,” Neuron, vol. 93, no. 2. Elsevier, pp. 308–314, 2017. ista: Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. 2017. Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. Neuron. 93(2), 308–314. mla: Gan, Jian, et al. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice in Vivo.” Neuron, vol. 93, no. 2, Elsevier, 2017, pp. 308–14, doi:10.1016/j.neuron.2016.12.018. short: J. Gan, S.-M. Weng, A. Pernia-Andrade, J.L. Csicsvari, P.M. Jonas, Neuron 93 (2017) 308–314. date_created: 2018-12-11T11:50:15Z date_published: 2017-01-18T00:00:00Z date_updated: 2023-09-20T11:31:48Z day: '18' ddc: - '571' department: - _id: PeJo - _id: JoCs doi: 10.1016/j.neuron.2016.12.018 ec_funded: 1 external_id: isi: - '000396428200010' file: - access_level: open_access content_type: application/pdf creator: system date_created: 2018-12-12T10:08:56Z date_updated: 2018-12-12T10:08:56Z file_id: '4719' file_name: IST-2017-752-v1+1_1-s2.0-S0896627316309606-main.pdf file_size: 2738950 relation: main_file file_date_updated: 2018-12-12T10:08:56Z has_accepted_license: '1' intvolume: ' 93' isi: 1 issue: '2' language: - iso: eng month: '01' oa: 1 oa_version: Published Version page: 308 - 314 project: - _id: 25C26B1E-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: P24909-B24 name: Mechanisms of transmitter release at GABAergic synapses - _id: 25C0F108-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '268548' name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons publication: Neuron publication_status: published publisher: Elsevier publist_id: '6244' pubrep_id: '752' quality_controlled: '1' scopus_import: '1' status: public title: Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 volume: 93 year: '2017' ... --- _id: '1132' abstract: - lang: eng text: The hippocampus is thought to initiate systems-wide mnemonic processes through the reactivation of previously acquired spatial and episodic memory traces, which can recruit the entorhinal cortex as a first stage of memory redistribution to other brain areas. Hippocampal reactivation occurs during sharp wave-ripples, in which synchronous network firing encodes sequences of places.We investigated the coordination of this replay by recording assembly activity simultaneously in the CA1 region of the hippocampus and superficial layers of the medial entorhinal cortex. We found that entorhinal cell assemblies can replay trajectories independently of the hippocampus and sharp wave-ripples. This suggests that the hippocampus is not the sole initiator of spatial and episodic memory trace reactivation. Memory systems involved in these processes may include nonhierarchical, parallel components. article_processing_charge: No author: - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Charlotte full_name: Boccara, Charlotte id: 3FC06552-F248-11E8-B48F-1D18A9856A87 last_name: Boccara orcid: 0000-0001-7237-5109 - first_name: Federico full_name: Stella, Federico id: 39AF1E74-F248-11E8-B48F-1D18A9856A87 last_name: Stella orcid: 0000-0001-9439-3148 - first_name: Philipp full_name: Schönenberger, Philipp id: 3B9D816C-F248-11E8-B48F-1D18A9856A87 last_name: Schönenberger - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. 2017;355(6321):184-188. doi:10.1126/science.aag2787 apa: O’Neill, J., Boccara, C. N., Stella, F., Schönenberger, P., & Csicsvari, J. L. (2017). Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aag2787 chicago: O’Neill, Joseph, Charlotte N. Boccara, Federico Stella, Philipp Schönenberger, and Jozsef L Csicsvari. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” Science. American Association for the Advancement of Science, 2017. https://doi.org/10.1126/science.aag2787. ieee: J. O’Neill, C. N. Boccara, F. Stella, P. Schönenberger, and J. L. Csicsvari, “Superficial layers of the medial entorhinal cortex replay independently of the hippocampus,” Science, vol. 355, no. 6321. American Association for the Advancement of Science, pp. 184–188, 2017. ista: O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. 2017. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. 355(6321), 184–188. mla: O’Neill, Joseph, et al. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” Science, vol. 355, no. 6321, American Association for the Advancement of Science, 2017, pp. 184–88, doi:10.1126/science.aag2787. short: J. O’Neill, C.N. Boccara, F. Stella, P. Schönenberger, J.L. Csicsvari, Science 355 (2017) 184–188. date_created: 2018-12-11T11:50:19Z date_published: 2017-01-13T00:00:00Z date_updated: 2023-09-20T11:30:35Z day: '13' ddc: - '571' department: - _id: JoCs doi: 10.1126/science.aag2787 ec_funded: 1 external_id: isi: - '000391743700044' file: - access_level: open_access content_type: application/pdf creator: system date_created: 2018-12-12T10:10:22Z date_updated: 2018-12-12T10:10:22Z file_id: '4809' file_name: IST-2018-976-v1+1_2017Preprint_ONeill_Superficial_layers.pdf file_size: 3761201 relation: main_file file_date_updated: 2018-12-12T10:10:22Z has_accepted_license: '1' intvolume: ' 355' isi: 1 issue: '6321' language: - iso: eng month: '01' oa: 1 oa_version: Submitted Version page: 184 - 188 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex publication: Science publication_identifier: issn: - '00368075' publication_status: published publisher: American Association for the Advancement of Science publist_id: '6226' pubrep_id: '976' quality_controlled: '1' scopus_import: '1' status: public title: Superficial layers of the medial entorhinal cortex replay independently of the hippocampus type: journal_article user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 volume: 355 year: '2017' ... --- _id: '1279' abstract: - lang: eng text: During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory inputdriven neuronal firing patterns are replayed. Such replay is thought to be important for plasticity- related processes and consolidation of memory traces. It has previously been shown that the electrical stimulation-induced disruption of SWR events interferes with learning in rodents in different experimental paradigms. On the other hand, the cognitive map theory posits that the plastic changes of the firing of hippocampal place cells constitute the electrophysiological counterpart of the spatial learning, observable at the behavioral level. Therefore, we tested whether intact SWR events occurring during the sleep/rest session after the first exploration of a novel environment are needed for the stabilization of the CA1 code, which process requires plasticity. We found that the newly-formed representation in the CA1 has the same level of stability with optogenetic SWR blockade as with a control manipulation that delivered the same amount of light into the brain. Therefore our results suggest that at least in the case of passive exploratory behavior, SWR-related plasticity is dispensable for the stability of CA1 ensembles. acknowledgement: 'The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union''s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n° [291734] via the IST FELLOWSHIP awarded to Dr. Krisztián A. Kovács and the European Research Council starting grant (acronym: HIPECMEM Project reference: 281511) awarded to Dr. Jozsef Csicsvari. We thank Lauri Viljanto for technical help in building the ripple detector.' article_number: e0164675 author: - first_name: Krisztián full_name: Kovács, Krisztián id: 2AB5821E-F248-11E8-B48F-1D18A9856A87 last_name: Kovács - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Philipp full_name: Schönenberger, Philipp id: 3B9D816C-F248-11E8-B48F-1D18A9856A87 last_name: Schönenberger - first_name: Markku full_name: Penttonen, Markku last_name: Penttonen - first_name: Dámaris K full_name: Rangel Guerrero, Dámaris K id: 4871BCE6-F248-11E8-B48F-1D18A9856A87 last_name: Rangel Guerrero orcid: 0000-0002-8602-4374 - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari JL. Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. PLoS One. 2016;11(10). doi:10.1371/journal.pone.0164675 apa: Kovács, K., O’Neill, J., Schönenberger, P., Penttonen, M., Rangel Guerrero, D. K., & Csicsvari, J. L. (2016). Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0164675 chicago: Kovács, Krisztián, Joseph O’Neill, Philipp Schönenberger, Markku Penttonen, Dámaris K Rangel Guerrero, and Jozsef L Csicsvari. “Optogenetically Blocking Sharp Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial Representation in the CA1 Area of the Hippocampus.” PLoS One. Public Library of Science, 2016. https://doi.org/10.1371/journal.pone.0164675. ieee: K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D. K. Rangel Guerrero, and J. L. Csicsvari, “Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus,” PLoS One, vol. 11, no. 10. Public Library of Science, 2016. ista: Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari JL. 2016. Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. PLoS One. 11(10), e0164675. mla: Kovács, Krisztián, et al. “Optogenetically Blocking Sharp Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial Representation in the CA1 Area of the Hippocampus.” PLoS One, vol. 11, no. 10, e0164675, Public Library of Science, 2016, doi:10.1371/journal.pone.0164675. short: K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D.K. Rangel Guerrero, J.L. Csicsvari, PLoS One 11 (2016). date_created: 2018-12-11T11:51:06Z date_published: 2016-10-19T00:00:00Z date_updated: 2021-01-12T06:49:35Z day: '19' ddc: - '570' - '571' department: - _id: JoCs doi: 10.1371/journal.pone.0164675 ec_funded: 1 file: - access_level: open_access checksum: 395895ecb2216e9c39135abaa56b28b3 content_type: application/pdf creator: system date_created: 2018-12-12T10:13:26Z date_updated: 2020-07-14T12:44:42Z file_id: '5009' file_name: IST-2016-690-v1+1_journal.pone.0164675.PDF file_size: 4353592 relation: main_file file_date_updated: 2020-07-14T12:44:42Z has_accepted_license: '1' intvolume: ' 11' issue: '10' language: - iso: eng month: '10' oa: 1 oa_version: Published Version project: - _id: 25681D80-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '291734' name: International IST Postdoc Fellowship Programme - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex publication: PLoS One publication_status: published publisher: Public Library of Science publist_id: '6037' pubrep_id: '690' quality_controlled: '1' scopus_import: 1 status: public title: Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 11 year: '2016' ... --- _id: '1334' abstract: - lang: eng text: Hippocampal neurons encode a cognitive map of space. These maps are thought to be updated during learning and in response to changes in the environment through activity-dependent synaptic plasticity. Here we examine how changes in activity influence spatial coding in rats using halorhodopsin-mediated, spatially selective optogenetic silencing. Halorhoposin stimulation leads to light-induced suppression in many place cells and interneurons; some place cells increase their firing through disinhibition, whereas some show no effect. We find that place fields of the unaffected subpopulation remain stable. On the other hand, place fields of suppressed place cells were unstable, showing remapping across sessions before and after optogenetic inhibition. Disinhibited place cells had stable maps but sustained an elevated firing rate. These findings suggest that place representation in the hippocampus is constantly governed by activity-dependent processes, and that disinhibition may provide a mechanism for rate remapping. article_number: '11824' author: - first_name: Philipp full_name: Schönenberger, Philipp id: 3B9D816C-F248-11E8-B48F-1D18A9856A87 last_name: Schönenberger - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Schönenberger P, O’Neill J, Csicsvari JL. Activity dependent plasticity of hippocampal place maps. Nature Communications. 2016;7. doi:10.1038/ncomms11824 apa: Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2016). Activity dependent plasticity of hippocampal place maps. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms11824 chicago: Schönenberger, Philipp, Joseph O’Neill, and Jozsef L Csicsvari. “Activity Dependent Plasticity of Hippocampal Place Maps.” Nature Communications. Nature Publishing Group, 2016. https://doi.org/10.1038/ncomms11824. ieee: P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Activity dependent plasticity of hippocampal place maps,” Nature Communications, vol. 7. Nature Publishing Group, 2016. ista: Schönenberger P, O’Neill J, Csicsvari JL. 2016. Activity dependent plasticity of hippocampal place maps. Nature Communications. 7, 11824. mla: Schönenberger, Philipp, et al. “Activity Dependent Plasticity of Hippocampal Place Maps.” Nature Communications, vol. 7, 11824, Nature Publishing Group, 2016, doi:10.1038/ncomms11824. short: P. Schönenberger, J. O’Neill, J.L. Csicsvari, Nature Communications 7 (2016). date_created: 2018-12-11T11:51:26Z date_published: 2016-06-10T00:00:00Z date_updated: 2021-01-12T06:49:57Z day: '10' ddc: - '570' department: - _id: JoCs doi: 10.1038/ncomms11824 ec_funded: 1 file: - access_level: open_access checksum: e43307754abe65b840a21939fe163618 content_type: application/pdf creator: system date_created: 2018-12-12T10:16:10Z date_updated: 2020-07-14T12:44:44Z file_id: '5196' file_name: IST-2016-660-v1+1_ncomms11824.pdf file_size: 1793846 relation: main_file file_date_updated: 2020-07-14T12:44:44Z has_accepted_license: '1' intvolume: ' 7' language: - iso: eng month: '06' oa: 1 oa_version: Published Version project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex - _id: 257D4372-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I2072-B27 name: Interneuron plasticity during spatial learning publication: Nature Communications publication_status: published publisher: Nature Publishing Group publist_id: '5934' pubrep_id: '660' quality_controlled: '1' scopus_import: 1 status: public title: Activity dependent plasticity of hippocampal place maps tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2016' ... --- _id: '2003' abstract: - lang: eng text: Learning can be facilitated by previous knowledge when it is organized into relational representations forming schemas. In this issue of Neuron, McKenzie et al. (2014) demonstrate that the hippocampus rapidly forms interrelated, hierarchical memory representations to support schema-based learning. author: - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: O’Neill J, Csicsvari JL. Learning by example in the hippocampus. Neuron. 2014;83(1):8-10. doi:10.1016/j.neuron.2014.06.013 apa: O’Neill, J., & Csicsvari, J. L. (2014). Learning by example in the hippocampus. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2014.06.013 chicago: O’Neill, Joseph, and Jozsef L Csicsvari. “Learning by Example in the Hippocampus.” Neuron. Elsevier, 2014. https://doi.org/10.1016/j.neuron.2014.06.013. ieee: J. O’Neill and J. L. Csicsvari, “Learning by example in the hippocampus,” Neuron, vol. 83, no. 1. Elsevier, pp. 8–10, 2014. ista: O’Neill J, Csicsvari JL. 2014. Learning by example in the hippocampus. Neuron. 83(1), 8–10. mla: O’Neill, Joseph, and Jozsef L. Csicsvari. “Learning by Example in the Hippocampus.” Neuron, vol. 83, no. 1, Elsevier, 2014, pp. 8–10, doi:10.1016/j.neuron.2014.06.013. short: J. O’Neill, J.L. Csicsvari, Neuron 83 (2014) 8–10. date_created: 2018-12-11T11:55:09Z date_published: 2014-07-02T00:00:00Z date_updated: 2021-01-12T06:54:39Z day: '02' department: - _id: JoCs doi: 10.1016/j.neuron.2014.06.013 intvolume: ' 83' issue: '1' language: - iso: eng month: '07' oa_version: None page: 8 - 10 publication: Neuron publication_status: published publisher: Elsevier publist_id: '5073' quality_controlled: '1' scopus_import: 1 status: public title: Learning by example in the hippocampus type: journal_article user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87 volume: 83 year: '2014' ... --- _id: '2005' abstract: - lang: eng text: By eliciting a natural exploratory behavior in rats, head scanning, a study reveals that hippocampal place cells form new, stable firing fields in those locations where the behavior has just occurred. author: - first_name: David full_name: Dupret, David last_name: Dupret - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Dupret D, Csicsvari JL. Turning heads to remember places. Nature Neuroscience. 2014;17(5):643-644. doi:10.1038/nn.3700 apa: Dupret, D., & Csicsvari, J. L. (2014). Turning heads to remember places. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3700 chicago: Dupret, David, and Jozsef L Csicsvari. “Turning Heads to Remember Places.” Nature Neuroscience. Nature Publishing Group, 2014. https://doi.org/10.1038/nn.3700. ieee: D. Dupret and J. L. Csicsvari, “Turning heads to remember places,” Nature Neuroscience, vol. 17, no. 5. Nature Publishing Group, pp. 643–644, 2014. ista: Dupret D, Csicsvari JL. 2014. Turning heads to remember places. Nature Neuroscience. 17(5), 643–644. mla: Dupret, David, and Jozsef L. Csicsvari. “Turning Heads to Remember Places.” Nature Neuroscience, vol. 17, no. 5, Nature Publishing Group, 2014, pp. 643–44, doi:10.1038/nn.3700. short: D. Dupret, J.L. Csicsvari, Nature Neuroscience 17 (2014) 643–644. date_created: 2018-12-11T11:55:09Z date_published: 2014-04-25T00:00:00Z date_updated: 2021-01-12T06:54:40Z day: '25' department: - _id: JoCs doi: 10.1038/nn.3700 intvolume: ' 17' issue: '5' language: - iso: eng month: '04' oa_version: None page: 643 - 644 publication: Nature Neuroscience publication_status: published publisher: Nature Publishing Group publist_id: '5071' quality_controlled: '1' scopus_import: 1 status: public title: Turning heads to remember places type: journal_article user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87 volume: 17 year: '2014' ... --- _id: '2251' abstract: - lang: eng text: 'Sharp wave/ripple (SWR, 150–250 Hz) hippocampal events have long been postulated to be involved in memory consolidation. However, more recent work has investigated SWRs that occur during active waking behaviour: findings that suggest that SWRs may also play a role in cell assembly strengthening or spatial working memory. Do such theories of SWR function apply to animal learning? This review discusses how general theories linking SWRs to memory-related function may explain circuit mechanisms related to rodent spatial learning and to the associated stabilization of new cognitive maps.' acknowledgement: CC BY 3.0 article_number: '20120528' article_processing_charge: No author: - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: David full_name: Dupret, David last_name: Dupret citation: ama: Csicsvari JL, Dupret D. Sharp wave/ripple network oscillations and learning-associated hippocampal maps. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences. 2014;369(1635). doi:10.1098/rstb.2012.0528 apa: Csicsvari, J. L., & Dupret, D. (2014). Sharp wave/ripple network oscillations and learning-associated hippocampal maps. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Royal Society, The. https://doi.org/10.1098/rstb.2012.0528 chicago: Csicsvari, Jozsef L, and David Dupret. “Sharp Wave/Ripple Network Oscillations and Learning-Associated Hippocampal Maps.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Royal Society, The, 2014. https://doi.org/10.1098/rstb.2012.0528. ieee: J. L. Csicsvari and D. Dupret, “Sharp wave/ripple network oscillations and learning-associated hippocampal maps,” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 369, no. 1635. Royal Society, The, 2014. ista: Csicsvari JL, Dupret D. 2014. Sharp wave/ripple network oscillations and learning-associated hippocampal maps. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369(1635), 20120528. mla: Csicsvari, Jozsef L., and David Dupret. “Sharp Wave/Ripple Network Oscillations and Learning-Associated Hippocampal Maps.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 369, no. 1635, 20120528, Royal Society, The, 2014, doi:10.1098/rstb.2012.0528. short: J.L. Csicsvari, D. Dupret, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369 (2014). date_created: 2018-12-11T11:56:34Z date_published: 2014-02-05T00:00:00Z date_updated: 2021-01-12T06:56:18Z day: '05' ddc: - '570' department: - _id: JoCs doi: 10.1098/rstb.2012.0528 external_id: pmid: - '24366138' file: - access_level: open_access checksum: 51beb33de71c9c19e0c205a20d206f9a content_type: application/pdf creator: system date_created: 2018-12-12T10:13:24Z date_updated: 2020-07-14T12:45:34Z file_id: '5006' file_name: IST-2016-527-v1+1_20120528.full.pdf file_size: 771896 relation: main_file file_date_updated: 2020-07-14T12:45:34Z has_accepted_license: '1' intvolume: ' 369' issue: '1635' language: - iso: eng month: '02' oa: 1 oa_version: Published Version pmid: 1 publication: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences publication_identifier: issn: - '09628436' publication_status: published publisher: Royal Society, The publist_id: '4697' pubrep_id: '527' quality_controlled: '1' scopus_import: 1 status: public title: Sharp wave/ripple network oscillations and learning-associated hippocampal maps tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 369 year: '2014' ... --- _id: '2860' abstract: - lang: eng text: 'In the hippocampus, cell assemblies forming mnemonic representations of space are thought to arise as a result of changes in functional connections of pyramidal cells. We have found that CA1 interneuron circuits are also reconfigured during goal-oriented spatial learning through modification of inputs from pyramidal cells. As learning progressed, new pyramidal assemblies expressed in theta cycles alternated with previously established ones, and eventually overtook them. The firing patterns of interneurons developed a relationship to new, learning-related assemblies: some interneurons associated their activity with new pyramidal assemblies while some others dissociated from them. These firing associations were explained by changes in the weight of monosynaptic inputs received by interneurons from new pyramidal assemblies, as these predicted the associational changes. Spatial learning thus engages circuit modifications in the hippocampus that incorporate a redistribution of inhibitory activity that might assist in the segregation of competing pyramidal cell assembly patterns in space and time.' acknowledgement: D.D. and J.C. were supported by a MRC Intramural Programme Grant U138197111 author: - first_name: David full_name: Dupret, David last_name: Dupret - first_name: Joseph full_name: O'Neill, Joseph id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Dupret D, O’Neill J, Csicsvari JL. Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning. Neuron. 2013;78(1):166-180. doi:10.1016/j.neuron.2013.01.033 apa: Dupret, D., O’Neill, J., & Csicsvari, J. L. (2013). Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2013.01.033 chicago: Dupret, David, Joseph O’Neill, and Jozsef L Csicsvari. “Dynamic Reconfiguration of Hippocampal Interneuron Circuits during Spatial Learning.” Neuron. Elsevier, 2013. https://doi.org/10.1016/j.neuron.2013.01.033. ieee: D. Dupret, J. O’Neill, and J. L. Csicsvari, “Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning,” Neuron, vol. 78, no. 1. Elsevier, pp. 166–180, 2013. ista: Dupret D, O’Neill J, Csicsvari JL. 2013. Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning. Neuron. 78(1), 166–180. mla: Dupret, David, et al. “Dynamic Reconfiguration of Hippocampal Interneuron Circuits during Spatial Learning.” Neuron, vol. 78, no. 1, Elsevier, 2013, pp. 166–80, doi:10.1016/j.neuron.2013.01.033. short: D. Dupret, J. O’Neill, J.L. Csicsvari, Neuron 78 (2013) 166–180. date_created: 2018-12-11T11:59:59Z date_published: 2013-03-21T00:00:00Z date_updated: 2021-01-12T07:00:19Z day: '21' ddc: - '570' department: - _id: JoCs doi: 10.1016/j.neuron.2013.01.033 ec_funded: 1 file: - access_level: open_access checksum: 0e18cb8561153ddb50bb5af16e7c9e97 content_type: application/pdf creator: dernst date_created: 2019-01-23T08:08:07Z date_updated: 2020-07-14T12:45:52Z file_id: '5877' file_name: 2013_Neuron_Dupret.pdf file_size: 2637837 relation: main_file file_date_updated: 2020-07-14T12:45:52Z has_accepted_license: '1' intvolume: ' 78' issue: '1' language: - iso: eng month: '03' oa: 1 oa_version: Published Version page: 166 - 180 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex publication: Neuron publication_status: published publisher: Elsevier publist_id: '3929' quality_controlled: '1' scopus_import: 1 status: public title: Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 78 year: '2013' ... --- _id: '2949' author: - first_name: David full_name: Dupret, David last_name: Dupret - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Dupret D, Csicsvari JL. The medial entorhinal cortex keeps Up. Nature Neuroscience. 2012;15(11):1471-1472. doi:10.1038/nn.3245 apa: Dupret, D., & Csicsvari, J. L. (2012). The medial entorhinal cortex keeps Up. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3245 chicago: Dupret, David, and Jozsef L Csicsvari. “The Medial Entorhinal Cortex Keeps Up.” Nature Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nn.3245. ieee: D. Dupret and J. L. Csicsvari, “The medial entorhinal cortex keeps Up,” Nature Neuroscience, vol. 15, no. 11. Nature Publishing Group, pp. 1471–1472, 2012. ista: Dupret D, Csicsvari JL. 2012. The medial entorhinal cortex keeps Up. Nature Neuroscience. 15(11), 1471–1472. mla: Dupret, David, and Jozsef L. Csicsvari. “The Medial Entorhinal Cortex Keeps Up.” Nature Neuroscience, vol. 15, no. 11, Nature Publishing Group, 2012, pp. 1471–72, doi:10.1038/nn.3245. short: D. Dupret, J.L. Csicsvari, Nature Neuroscience 15 (2012) 1471–1472. date_created: 2018-12-11T12:00:30Z date_published: 2012-11-01T00:00:00Z date_updated: 2021-01-12T07:39:59Z day: '01' department: - _id: JoCs doi: 10.1038/nn.3245 intvolume: ' 15' issue: '11' language: - iso: eng main_file_link: - url: http://www.mrcbndu.ox.ac.uk/publications/medial-entorhinal-cortex-keeps month: '11' oa_version: None page: 1471 - 1472 publication: Nature Neuroscience publication_status: published publisher: Nature Publishing Group publist_id: '3782' quality_controlled: '1' scopus_import: 1 status: public title: The medial entorhinal cortex keeps Up type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 15 year: '2012' ... --- _id: '2958' abstract: - lang: eng text: 'The activity of hippocampal pyramidal cells reflects both the current position of the animal and information related to its current behavior. Here we investigated whether single hippocampal neurons can encode several independent features defining trials during a memory task. We also tested whether task-related information is represented by partial remapping of the place cell population or, instead, via firing rate modulation of spatially stable place cells. To address these two questions, the activity of hippocampal neurons was recorded in rats performing a conditional discrimination task on a modified T-maze in which the identity of a food reward guided behavior. When the rat was on the central arm of the maze, the firing rate of pyramidal cells changed depending on two independent factors: (1) the identity of the food reward given to the animal and (2) the previous location of the animal on the maze. Importantly, some pyramidal cells encoded information relative to both factors. This trial-type specific and retrospective coding did not interfere with the spatial representation of the maze: hippocampal cells had stable place fields and their theta-phase precession profiles were unaltered during the task, indicating that trial-related information was encoded via rate remapping. During error trials, encoding of both trial-related information and spatial location was impaired. Finally, we found that pyramidal cells also encode trial-related information via rate remapping during the continuous version of the rewarded alternation task without delays. These results suggest that hippocampal neurons can encode several task-related cognitive aspects via rate remapping.' acknowledgement: J.C. was supported by a MRC Intramural Programme Grant (U138197111) and a European Research Council Starter Grant (281511). K.A. held a Wellcome Trust PhD studentship and a Humboldt Research Fellowship for Postdoctoral Researchers. D.M.B. was supported by Wellcome Trust Senior Fellowships (074385 and 087736). author: - first_name: Kevin full_name: Allen, Kevin last_name: Allen - first_name: J Nick full_name: Rawlins, J Nick last_name: Rawlins - first_name: David full_name: Bannerman, David last_name: Bannerman - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. Hippocampal place cells can encode multiple trial-dependent features through rate remapping. Journal of Neuroscience. 2012;32(42):14752-14766. doi:10.1523/JNEUROSCI.6175-11.2012 apa: Allen, K., Rawlins, J. N., Bannerman, D., & Csicsvari, J. L. (2012). Hippocampal place cells can encode multiple trial-dependent features through rate remapping. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.6175-11.2012 chicago: Allen, Kevin, J Nick Rawlins, David Bannerman, and Jozsef L Csicsvari. “Hippocampal Place Cells Can Encode Multiple Trial-Dependent Features through Rate Remapping.” Journal of Neuroscience. Society for Neuroscience, 2012. https://doi.org/10.1523/JNEUROSCI.6175-11.2012. ieee: K. Allen, J. N. Rawlins, D. Bannerman, and J. L. Csicsvari, “Hippocampal place cells can encode multiple trial-dependent features through rate remapping,” Journal of Neuroscience, vol. 32, no. 42. Society for Neuroscience, pp. 14752–14766, 2012. ista: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. 2012. Hippocampal place cells can encode multiple trial-dependent features through rate remapping. Journal of Neuroscience. 32(42), 14752–14766. mla: Allen, Kevin, et al. “Hippocampal Place Cells Can Encode Multiple Trial-Dependent Features through Rate Remapping.” Journal of Neuroscience, vol. 32, no. 42, Society for Neuroscience, 2012, pp. 14752–66, doi:10.1523/JNEUROSCI.6175-11.2012. short: K. Allen, J.N. Rawlins, D. Bannerman, J.L. Csicsvari, Journal of Neuroscience 32 (2012) 14752–14766. date_created: 2018-12-11T12:00:33Z date_published: 2012-10-17T00:00:00Z date_updated: 2021-01-12T07:40:03Z day: '17' department: - _id: JoCs doi: 10.1523/JNEUROSCI.6175-11.2012 ec_funded: 1 external_id: pmid: - '23077060' intvolume: ' 32' issue: '42' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531717/ month: '10' oa: 1 oa_version: Submitted Version page: 14752 - 14766 pmid: 1 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '3768' quality_controlled: '1' scopus_import: 1 status: public title: Hippocampal place cells can encode multiple trial-dependent features through rate remapping type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 32 year: '2012' ... --- _id: '3138' abstract: - lang: eng text: Hippocampal sharp waves (SPWs) and associated fast ("ripple") oscillations (SPW-Rs) in the CA1 region are among the most synchronous physiological patterns in the mammalian brain. Using two-dimensional arrays of electrodes for recording local field potentials and unit discharges in freely moving rats, we studied the emergence of ripple oscillations (140-220 Hz) and compared their origin and cellular-synaptic mechanisms with fast gamma oscillations (90-140 Hz). We show that (1) hippocampal SPW-Rs and fast gamma oscillations are quantitatively distinct patterns but involve the same networks and share similar mechanisms; (2) both the frequency and magnitude of fast oscillations are positively correlated with the magnitude of SPWs; (3) during both ripples and fast gamma oscillations the frequency of network oscillation is higher in CA1 than in CA3; and (4) the emergence of CA3 population bursts, a prerequisite for SPW-Rs, is biased by activity patterns in the dentate gyrus and entorhinal cortex, with the highest probability of ripples associated with an "optimum" level of dentate gamma power. We hypothesize that each hippocampal subnetwork possesses distinct resonant properties, tuned by the magnitude of the excitatory drive. author: - first_name: David full_name: Sullivan, David W last_name: Sullivan - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Kenji full_name: Mizuseki, Kenji last_name: Mizuseki - first_name: Sean full_name: Montgomery, Sean M last_name: Montgomery - first_name: Kamran full_name: Diba, Kamran last_name: Diba - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Sullivan D, Csicsvari JL, Mizuseki K, Montgomery S, Diba K, Buzsáki G. Relationships between hippocampal sharp waves ripples and fast gamma oscillation Influence of dentate and entorhinal cortical activity. Journal of Neuroscience. 2011;31(23):8605-8616. doi:10.1523/JNEUROSCI.0294-11.2011 apa: Sullivan, D., Csicsvari, J. L., Mizuseki, K., Montgomery, S., Diba, K., & Buzsáki, G. (2011). Relationships between hippocampal sharp waves ripples and fast gamma oscillation Influence of dentate and entorhinal cortical activity. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0294-11.2011 chicago: Sullivan, David, Jozsef L Csicsvari, Kenji Mizuseki, Sean Montgomery, Kamran Diba, and György Buzsáki. “Relationships between Hippocampal Sharp Waves Ripples and Fast Gamma Oscillation Influence of Dentate and Entorhinal Cortical Activity.” Journal of Neuroscience. Society for Neuroscience, 2011. https://doi.org/10.1523/JNEUROSCI.0294-11.2011. ieee: D. Sullivan, J. L. Csicsvari, K. Mizuseki, S. Montgomery, K. Diba, and G. Buzsáki, “Relationships between hippocampal sharp waves ripples and fast gamma oscillation Influence of dentate and entorhinal cortical activity,” Journal of Neuroscience, vol. 31, no. 23. Society for Neuroscience, pp. 8605–8616, 2011. ista: Sullivan D, Csicsvari JL, Mizuseki K, Montgomery S, Diba K, Buzsáki G. 2011. Relationships between hippocampal sharp waves ripples and fast gamma oscillation Influence of dentate and entorhinal cortical activity. Journal of Neuroscience. 31(23), 8605–8616. mla: Sullivan, David, et al. “Relationships between Hippocampal Sharp Waves Ripples and Fast Gamma Oscillation Influence of Dentate and Entorhinal Cortical Activity.” Journal of Neuroscience, vol. 31, no. 23, Society for Neuroscience, 2011, pp. 8605–16, doi:10.1523/JNEUROSCI.0294-11.2011. short: D. Sullivan, J.L. Csicsvari, K. Mizuseki, S. Montgomery, K. Diba, G. Buzsáki, Journal of Neuroscience 31 (2011) 8605–8616. date_created: 2018-12-11T12:01:36Z date_published: 2011-06-08T00:00:00Z date_updated: 2021-01-12T07:41:19Z day: '08' doi: 10.1523/JNEUROSCI.0294-11.2011 extern: 1 intvolume: ' 31' issue: '23' month: '06' page: 8605 - 8616 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '3559' quality_controlled: 0 status: public title: Relationships between hippocampal sharp waves ripples and fast gamma oscillation Influence of dentate and entorhinal cortical activity type: journal_article volume: 31 year: '2011' ... --- _id: '3441' abstract: - lang: eng text: The hippocampus is an important brain circuit for spatial memory and the spatially selective spiking of hippocampal neuronal assemblies is thought to provide a mnemonic representation of space. We found that remembering newly learnt goal locations required NMDA receptorĝ€"dependent stabilization and enhanced reactivation of goal-related hippocampal assemblies. During spatial learning, place-related firing patterns in the CA1, but not CA3, region of the rat hippocampus were reorganized to represent new goal locations. Such reorganization did not occur when goals were marked by visual cues. The stabilization and successful retrieval of these newly acquired CA1 representations of behaviorally relevant places was NMDAR dependent and necessary for subsequent memory retention performance. Goal-related assembly patterns associated with sharp wave/ripple network oscillations, during both learning and subsequent rest periods, predicted memory performance. Together, these results suggest that the reorganization and reactivation of assembly firing patterns in the hippocampus represent the formation and expression of new spatial memory traces. © 2010 Nature America, Inc. All rights reserved. acknowledgement: | Discussed in the News and Views section of the journal by Jeffery and Cacucci author: - first_name: David full_name: Dupret, David last_name: Dupret - first_name: Joseph full_name: Joseph O'Neill id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Barty full_name: Pleydell-Bouverie, Barty last_name: Pleydell Bouverie - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Dupret D, O’Neill J, Pleydell Bouverie B, Csicsvari JL. The reorganization and reactivation of hippocampal maps predict spatial memory performance. Nature Neuroscience. 2010;13(8):995-1002. doi:10.1038/nn.2599 apa: Dupret, D., O’Neill, J., Pleydell Bouverie, B., & Csicsvari, J. L. (2010). The reorganization and reactivation of hippocampal maps predict spatial memory performance. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.2599 chicago: Dupret, David, Joseph O’Neill, Barty Pleydell Bouverie, and Jozsef L Csicsvari. “The Reorganization and Reactivation of Hippocampal Maps Predict Spatial Memory Performance.” Nature Neuroscience. Nature Publishing Group, 2010. https://doi.org/10.1038/nn.2599. ieee: D. Dupret, J. O’Neill, B. Pleydell Bouverie, and J. L. Csicsvari, “The reorganization and reactivation of hippocampal maps predict spatial memory performance,” Nature Neuroscience, vol. 13, no. 8. Nature Publishing Group, pp. 995–1002, 2010. ista: Dupret D, O’Neill J, Pleydell Bouverie B, Csicsvari JL. 2010. The reorganization and reactivation of hippocampal maps predict spatial memory performance. Nature Neuroscience. 13(8), 995–1002. mla: Dupret, David, et al. “The Reorganization and Reactivation of Hippocampal Maps Predict Spatial Memory Performance.” Nature Neuroscience, vol. 13, no. 8, Nature Publishing Group, 2010, pp. 995–1002, doi:10.1038/nn.2599. short: D. Dupret, J. O’Neill, B. Pleydell Bouverie, J.L. Csicsvari, Nature Neuroscience 13 (2010) 995–1002. date_created: 2018-12-11T12:03:21Z date_published: 2010-08-01T00:00:00Z date_updated: 2021-01-12T07:43:29Z day: '01' doi: 10.1038/nn.2599 extern: 1 intvolume: ' 13' issue: '8' month: '08' page: 995 - 1002 publication: Nature Neuroscience publication_status: published publisher: Nature Publishing Group publist_id: '2946' quality_controlled: 0 status: public title: The reorganization and reactivation of hippocampal maps predict spatial memory performance type: journal_article volume: 13 year: '2010' ... --- _id: '3442' abstract: - lang: eng text: Episodic and spatial memories each involve the encoding of complex associations in hippocampal neuronal circuits. Such memory traces could be stabilised from short- to long-term forms by consolidation processes involving the 'reactivation' of the original network firing patterns during sleep and rest. Waking experience can be replayed in many different brain areas, but an important role for the hippocampus lies in the organisation of the 'reactivation' process. Emerging evidence suggests that sharp wave/ripple (SWR) events in the hippocampus could coordinate the reactivation of memory traces and direct their reinstatement in cortical circuits. Although the mechanisms remain uncertain, there is a growing consensus that such SWR-directed reactivation of brain-wide memory traces could underlie memory consolidation. © 2010 Elsevier Ltd. author: - first_name: Joseph full_name: Joseph O'Neill id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Barty full_name: Pleydell-Bouverie, Barty last_name: Pleydell Bouverie - first_name: David full_name: Dupret, David last_name: Dupret - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: 'O’Neill J, Pleydell Bouverie B, Dupret D, Csicsvari JL. Play it again: reactivation of waking experience and memory. Trends in Neurosciences. 2010;33(5):220-229. doi:10.1016/j.tins.2010.01.006' apa: 'O’Neill, J., Pleydell Bouverie, B., Dupret, D., & Csicsvari, J. L. (2010). Play it again: reactivation of waking experience and memory. Trends in Neurosciences. Elsevier. https://doi.org/10.1016/j.tins.2010.01.006' chicago: 'O’Neill, Joseph, Barty Pleydell Bouverie, David Dupret, and Jozsef L Csicsvari. “Play It Again: Reactivation of Waking Experience and Memory.” Trends in Neurosciences. Elsevier, 2010. https://doi.org/10.1016/j.tins.2010.01.006.' ieee: 'J. O’Neill, B. Pleydell Bouverie, D. Dupret, and J. L. Csicsvari, “Play it again: reactivation of waking experience and memory,” Trends in Neurosciences, vol. 33, no. 5. Elsevier, pp. 220–229, 2010.' ista: 'O’Neill J, Pleydell Bouverie B, Dupret D, Csicsvari JL. 2010. Play it again: reactivation of waking experience and memory. Trends in Neurosciences. 33(5), 220–229.' mla: 'O’Neill, Joseph, et al. “Play It Again: Reactivation of Waking Experience and Memory.” Trends in Neurosciences, vol. 33, no. 5, Elsevier, 2010, pp. 220–29, doi:10.1016/j.tins.2010.01.006.' short: J. O’Neill, B. Pleydell Bouverie, D. Dupret, J.L. Csicsvari, Trends in Neurosciences 33 (2010) 220–229. date_created: 2018-12-11T12:03:21Z date_published: 2010-05-01T00:00:00Z date_updated: 2021-01-12T07:43:29Z day: '01' doi: 10.1016/j.tins.2010.01.006 extern: 1 intvolume: ' 33' issue: '5' month: '05' page: 220 - 229 publication: Trends in Neurosciences publication_status: published publisher: Elsevier publist_id: '2945' quality_controlled: 0 status: public title: 'Play it again: reactivation of waking experience and memory' type: journal_article volume: 33 year: '2010' ... --- _id: '3538' abstract: - lang: eng text: How seizures start is a major question in epilepsy research. Preictal EEG changes occur in both human patients and animal models, but their underlying mechanisms and relationship with seizure initiation remain unknown. Here we demonstrate the existence, in the hippocampal CA1 region, of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) (> 100 Hz) and reduction in system complexity. HFA is generated by the firing of neurons, mainly pyramidal cells, at much lower frequencies. Individual cycles of HFA are generated by the near-synchronous (within similar to 5 ms) firing of small numbers of pyramidal cells. The presence of HFA in the low-calcium model implicates nonsynaptic synchronization; the presence of very similar HFA in the high-potassium model shows that it does not depend on an absence of synaptic transmission. Immediately before seizure onset, CA1 is in a state of high sensitivity in which weak depolarizing or synchronizing perturbations can trigger seizures. Transition to seizure is characterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure. author: - first_name: Premysl full_name: Jiruska, Premysl last_name: Jiruska - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Andrew full_name: Powell, Andrew last_name: Powell - first_name: John full_name: Fox, John last_name: Fox - first_name: Wei full_name: Chang, Wei last_name: Chang - first_name: Martin full_name: Vreugdenhil, Martin last_name: Vreugdenhil - first_name: Xiaoli full_name: Li, Xiaoli last_name: Li - first_name: Milan full_name: Palus, Milan last_name: Palus - first_name: Alejandro full_name: Bujan, Alejandro last_name: Bujan - first_name: Richard full_name: Dearden, Richard last_name: Dearden - first_name: John full_name: Jefferys, John last_name: Jefferys citation: ama: Jiruska P, Csicsvari JL, Powell A, et al. High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro. Journal of Neuroscience. 2010;30(16):5690-5701. doi:10.1523/JNEUROSCI.0535-10.2010 apa: Jiruska, P., Csicsvari, J. L., Powell, A., Fox, J., Chang, W., Vreugdenhil, M., … Jefferys, J. (2010). High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0535-10.2010 chicago: Jiruska, Premysl, Jozsef L Csicsvari, Andrew Powell, John Fox, Wei Chang, Martin Vreugdenhil, Xiaoli Li, et al. “High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro.” Journal of Neuroscience. Society for Neuroscience, 2010. https://doi.org/10.1523/JNEUROSCI.0535-10.2010. ieee: P. Jiruska et al., “High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro,” Journal of Neuroscience, vol. 30, no. 16. Society for Neuroscience, pp. 5690–5701, 2010. ista: Jiruska P, Csicsvari JL, Powell A, Fox J, Chang W, Vreugdenhil M, Li X, Palus M, Bujan A, Dearden R, Jefferys J. 2010. High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro. Journal of Neuroscience. 30(16), 5690–5701. mla: Jiruska, Premysl, et al. “High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro.” Journal of Neuroscience, vol. 30, no. 16, Society for Neuroscience, 2010, pp. 5690–701, doi:10.1523/JNEUROSCI.0535-10.2010. short: P. Jiruska, J.L. Csicsvari, A. Powell, J. Fox, W. Chang, M. Vreugdenhil, X. Li, M. Palus, A. Bujan, R. Dearden, J. Jefferys, Journal of Neuroscience 30 (2010) 5690–5701. date_created: 2018-12-11T12:03:51Z date_published: 2010-04-21T00:00:00Z date_updated: 2021-01-12T07:44:10Z day: '21' doi: 10.1523/JNEUROSCI.0535-10.2010 extern: '1' intvolume: ' 30' issue: '16' language: - iso: eng main_file_link: - open_access: '1' url: http://www.jneurosci.org/content/30/16/5690 month: '04' oa: 1 oa_version: None page: 5690 - 5701 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '2848' quality_controlled: '1' status: public title: High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 30 year: '2010' ... --- _id: '3403' abstract: - lang: eng text: Rate remapping is a conjunctive code that potentially enables hippocampal place cells to jointly represent spatial and nonspatial information. In this issue of Neuron, Rennó-Costa et al. introduce a theoretical model wherein the convergence of the medial and lateral entorhinal excitatory inputs, combined with local inhibition, explains hippocampal rate remapping. © 2010 Elsevier Inc. author: - first_name: Barty full_name: Pleydell-Bouverie, Barty last_name: Pleydell Bouverie - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: 'Pleydell Bouverie B, Csicsvari JL. Rate remapping: When the code goes beyond space (preview). Neuron. 2010;68(6):1015-1016. doi:10.1016/j.neuron.2010.12.011' apa: 'Pleydell Bouverie, B., & Csicsvari, J. L. (2010). Rate remapping: When the code goes beyond space (preview). Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2010.12.011' chicago: 'Pleydell Bouverie, Barty, and Jozsef L Csicsvari. “Rate Remapping: When the Code Goes beyond Space (Preview).” Neuron. Elsevier, 2010. https://doi.org/10.1016/j.neuron.2010.12.011.' ieee: 'B. Pleydell Bouverie and J. L. Csicsvari, “Rate remapping: When the code goes beyond space (preview),” Neuron, vol. 68, no. 6. Elsevier, pp. 1015–1016, 2010.' ista: 'Pleydell Bouverie B, Csicsvari JL. 2010. Rate remapping: When the code goes beyond space (preview). Neuron. 68(6), 1015–1016.' mla: 'Pleydell Bouverie, Barty, and Jozsef L. Csicsvari. “Rate Remapping: When the Code Goes beyond Space (Preview).” Neuron, vol. 68, no. 6, Elsevier, 2010, pp. 1015–16, doi:10.1016/j.neuron.2010.12.011.' short: B. Pleydell Bouverie, J.L. Csicsvari, Neuron 68 (2010) 1015–1016. date_created: 2018-12-11T12:03:08Z date_published: 2010-12-22T00:00:00Z date_updated: 2019-05-10T12:19:51Z day: '22' doi: 10.1016/j.neuron.2010.12.011 extern: 1 intvolume: ' 68' issue: '6' month: '12' page: 1015 - 1016 publication: Neuron publication_status: published publisher: Elsevier publist_id: '2999' quality_controlled: 0 status: public title: 'Rate remapping: When the code goes beyond space (preview)' type: review volume: 68 year: '2010' ... --- _id: '3547' abstract: - lang: eng text: Neurons possess elaborate dendritic arbors which receive and integrate excitatory synaptic signals. Individual dendritic subbranches exhibit local membrane potential supralinearities, termed dendritic spikes, which control transfer of local synaptic input to the soma. Here, we show that dendritic spikes in CA1 pyramidal cells are strongly regulated by specific types of prior input. While input in the linear range is without effect, supralinear input inhibits subsequent spikes, causing them to attenuate and ultimately fail due to dendritic Na+ channel inactivation. This mechanism acts locally within the boundaries of the input branch. If an input is sufficiently strong to trigger axonal action potentials, their back-propagation into the dendritic tree causes a widespread global reduction in dendritic excitability which is prominent after firing patterns occurring in vivo. Together, these mechanisms control the capability of individual dendritic branches to trigger somatic action potential output. They are invoked at frequencies encountered during learning, and impose limits on the storage and retrieval rates of information encoded as branch excitability. author: - first_name: Stefan full_name: Remy,Stefan last_name: Remy - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Heinz full_name: Beck,Heinz last_name: Beck citation: ama: Remy S, Csicsvari JL, Beck H. Activity-dependent control of neuronal output by local and global dendritic spike attenuation. Neuron. 2009;61(6):906-916. doi:10.1016/j.neuron.2009.01.032 apa: Remy, S., Csicsvari, J. L., & Beck, H. (2009). Activity-dependent control of neuronal output by local and global dendritic spike attenuation. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2009.01.032 chicago: Remy, Stefan, Jozsef L Csicsvari, and Heinz Beck. “Activity-Dependent Control of Neuronal Output by Local and Global Dendritic Spike Attenuation.” Neuron. Elsevier, 2009. https://doi.org/10.1016/j.neuron.2009.01.032. ieee: S. Remy, J. L. Csicsvari, and H. Beck, “Activity-dependent control of neuronal output by local and global dendritic spike attenuation,” Neuron, vol. 61, no. 6. Elsevier, pp. 906–916, 2009. ista: Remy S, Csicsvari JL, Beck H. 2009. Activity-dependent control of neuronal output by local and global dendritic spike attenuation. Neuron. 61(6), 906–916. mla: Remy, Stefan, et al. “Activity-Dependent Control of Neuronal Output by Local and Global Dendritic Spike Attenuation.” Neuron, vol. 61, no. 6, Elsevier, 2009, pp. 906–16, doi:10.1016/j.neuron.2009.01.032. short: S. Remy, J.L. Csicsvari, H. Beck, Neuron 61 (2009) 906–916. date_created: 2018-12-11T12:03:54Z date_published: 2009-03-26T00:00:00Z date_updated: 2021-01-12T07:44:13Z day: '26' doi: 10.1016/j.neuron.2009.01.032 extern: 1 intvolume: ' 61' issue: '6' month: '03' page: 906 - 916 publication: Neuron publication_status: published publisher: Elsevier publist_id: '2838' quality_controlled: 0 status: public title: Activity-dependent control of neuronal output by local and global dendritic spike attenuation type: journal_article volume: 61 year: '2009' ... --- _id: '3520' abstract: - lang: eng text: The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places increased relative to the sleep session before exploration. This cofiring increase depended on the number of times that cells fired together with short latencies ( < 50 ms) during exploration, and was strongest between cells representing the most visited places. This is indicative of a Hebbian learning rule in which changes in firing associations between cells are determined by the number of waking coincident firing events. In contrast, cells encoding different locations reduced their cofiring in proportion to the number of times that they fired independently. Together these data indicate that reactivated patterns are shaped by both positive and negative changes in cofiring, which are determined by recent behavior. author: - first_name: Joseph full_name: Joseph O'Neill id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Timothy full_name: Senior,Timothy J last_name: Senior - first_name: Kevin full_name: Allen, Kevin last_name: Allen - first_name: John full_name: Huxter,John R last_name: Huxter - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience. 2008;11(2):209-215. doi:10.1038/nn2037 apa: O’Neill, J., Senior, T., Allen, K., Huxter, J., & Csicsvari, J. L. (2008). Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn2037 chicago: O’Neill, Joseph, Timothy Senior, Kevin Allen, John Huxter, and Jozsef L Csicsvari. “Reactivation of Experience-Dependent Cell Assembly Patterns in the Hippocampus.” Nature Neuroscience. Nature Publishing Group, 2008. https://doi.org/10.1038/nn2037. ieee: J. O’Neill, T. Senior, K. Allen, J. Huxter, and J. L. Csicsvari, “Reactivation of experience-dependent cell assembly patterns in the hippocampus,” Nature Neuroscience, vol. 11, no. 2. Nature Publishing Group, pp. 209–215, 2008. ista: O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. 2008. Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience. 11(2), 209–215. mla: O’Neill, Joseph, et al. “Reactivation of Experience-Dependent Cell Assembly Patterns in the Hippocampus.” Nature Neuroscience, vol. 11, no. 2, Nature Publishing Group, 2008, pp. 209–15, doi:10.1038/nn2037. short: J. O’Neill, T. Senior, K. Allen, J. Huxter, J.L. Csicsvari, Nature Neuroscience 11 (2008) 209–215. date_created: 2018-12-11T12:03:46Z date_published: 2008-02-01T00:00:00Z date_updated: 2021-01-12T07:44:02Z day: '01' doi: 10.1038/nn2037 extern: 1 intvolume: ' 11' issue: '2' month: '02' page: 209 - 215 publication: Nature Neuroscience publication_status: published publisher: Nature Publishing Group publist_id: '2864' quality_controlled: 0 status: public title: Reactivation of experience-dependent cell assembly patterns in the hippocampus type: journal_article volume: 11 year: '2008' ... --- _id: '3537' abstract: - lang: eng text: 'Hippocampal place cells that fire together within the same cycle of theta oscillations represent the sequence of positions (movement trajectory) that a rat traverses on a linear track. Furthermore, it has been suggested that the encoding of these and other types of temporal memory sequences is organized by gamma oscillations nested within theta oscillations. Here, we examined whether gamma-related firing of place cells permits such discrete temporal coding. We found that gamma-modulated CA1 pyramidal cells separated into two classes on the basis of gamma firing phases during waking theta periods. These groups also differed in terms of their spike waveforms, firing rates, and burst firing tendency. During gamma oscillations one group''s firing became restricted to theta phases associated with the highest gamma power. Consequently, on the linear track, cells in this group often failed to fire early in theta-phase precession (as the rat entered the place field) if gamma oscillations were present. The second group fired throughout the theta cycle during gamma oscillations, and maintained gamma-modulated firing at different stages of theta-phase precession. Our results suggest that the two different pyramidal cell classes may support different types of population codes within a theta cycle: one in which spike sequences representing movement trajectories occur across subsequent gamma cycles nested within each theta cycle, and another in which firing in synchronized gamma discharges without temporal sequences encode a representation of location. We propose that gamma oscillations during theta-phase precession organize the mnemonic recall of population patterns representing places and movement paths.' author: - first_name: Timothy full_name: Senior,Timothy J last_name: Senior - first_name: John full_name: Huxter,John R last_name: Huxter - first_name: Kevin full_name: Allen, Kevin last_name: Allen - first_name: Joseph full_name: Joseph O'Neill id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. Gamma oscillatory firing reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus. Journal of Neuroscience. 2008;28(9):2274-2286. doi:10.1523/JNEUROSCI.4669-07.2008 apa: Senior, T., Huxter, J., Allen, K., O’Neill, J., & Csicsvari, J. L. (2008). Gamma oscillatory firing reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.4669-07.2008 chicago: Senior, Timothy, John Huxter, Kevin Allen, Joseph O’Neill, and Jozsef L Csicsvari. “Gamma Oscillatory Firing Reveals Distinct Populations of Pyramidal Cells in the CA1 Region of the Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 2008. https://doi.org/10.1523/JNEUROSCI.4669-07.2008. ieee: T. Senior, J. Huxter, K. Allen, J. O’Neill, and J. L. Csicsvari, “Gamma oscillatory firing reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus,” Journal of Neuroscience, vol. 28, no. 9. Society for Neuroscience, pp. 2274–2286, 2008. ista: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. 2008. Gamma oscillatory firing reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus. Journal of Neuroscience. 28(9), 2274–2286. mla: Senior, Timothy, et al. “Gamma Oscillatory Firing Reveals Distinct Populations of Pyramidal Cells in the CA1 Region of the Hippocampus.” Journal of Neuroscience, vol. 28, no. 9, Society for Neuroscience, 2008, pp. 2274–86, doi:10.1523/JNEUROSCI.4669-07.2008. short: T. Senior, J. Huxter, K. Allen, J. O’Neill, J.L. Csicsvari, Journal of Neuroscience 28 (2008) 2274–2286. date_created: 2018-12-11T12:03:51Z date_published: 2008-02-27T00:00:00Z date_updated: 2021-01-12T07:44:09Z day: '27' doi: 10.1523/JNEUROSCI.4669-07.2008 extern: 1 intvolume: ' 28' issue: '9' month: '02' page: 2274 - 2286 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '2847' quality_controlled: 0 status: public title: Gamma oscillatory firing reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus type: journal_article volume: 28 year: '2008' ... --- _id: '3534' author: - first_name: David full_name: Dupret, David last_name: Dupret - first_name: Barty full_name: Pleydell-Bouverie, Barty last_name: Pleydell Bouverie - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Dupret D, Pleydell Bouverie B, Csicsvari JL. Inhibitory interneurons and network oscillations. PNAS. 2008;105(47):18079-18080. doi:10.1073/pnas.0810064105 apa: Dupret, D., Pleydell Bouverie, B., & Csicsvari, J. L. (2008). Inhibitory interneurons and network oscillations. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.0810064105 chicago: Dupret, David, Barty Pleydell Bouverie, and Jozsef L Csicsvari. “Inhibitory Interneurons and Network Oscillations.” PNAS. National Academy of Sciences, 2008. https://doi.org/10.1073/pnas.0810064105. ieee: D. Dupret, B. Pleydell Bouverie, and J. L. Csicsvari, “Inhibitory interneurons and network oscillations,” PNAS, vol. 105, no. 47. National Academy of Sciences, pp. 18079–18080, 2008. ista: Dupret D, Pleydell Bouverie B, Csicsvari JL. 2008. Inhibitory interneurons and network oscillations. PNAS. 105(47), 18079–18080. mla: Dupret, David, et al. “Inhibitory Interneurons and Network Oscillations.” PNAS, vol. 105, no. 47, National Academy of Sciences, 2008, pp. 18079–80, doi:10.1073/pnas.0810064105. short: D. Dupret, B. Pleydell Bouverie, J.L. Csicsvari, PNAS 105 (2008) 18079–18080. date_created: 2018-12-11T12:03:50Z date_published: 2008-11-25T00:00:00Z date_updated: 2021-01-12T07:44:08Z day: '25' doi: 10.1073/pnas.0810064105 extern: 1 intvolume: ' 105' issue: '47' month: '11' page: 18079 - 18080 publication: PNAS publication_status: published publisher: National Academy of Sciences publist_id: '2852' quality_controlled: 0 status: public title: Inhibitory interneurons and network oscillations type: journal_article volume: 105 year: '2008' ... --- _id: '3516' abstract: - lang: eng text: Temporal coding is a means of representing information by the time, as opposed to the rate, at which neurons fire. Evidence of temporal coding in the hippocampus comes from place cells, whose spike times relative to theta oscillations reflect a rat's position while running along stereotyped trajectories. This arises from the backwards shift in cell firing relative to local theta oscillations (phase precession). Here we demonstrate phase precession during place-field crossings in an open-field foraging task. This produced spike sequences in each theta cycle that disambiguate the rat's trajectory through two-dimensional space and can be used to predict movement direction. Furthermore, position and movement direction were maximally predicted from firing in the early and late portions of the theta cycle, respectively. This represents the first direct evidence of a combined representation of position, trajectory and heading in the hippocampus, organized on a fine temporal scale by theta oscillations. author: - first_name: John full_name: Huxter,John R last_name: Huxter - first_name: Timothy full_name: Senior,Timothy J last_name: Senior - first_name: Kevin full_name: Allen, Kevin last_name: Allen - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Huxter J, Senior T, Allen K, Csicsvari JL. Theta phase-specific codes for two-dimensional position, trajectory and heading in the hippocampus. Nature Neuroscience. 2008;11(5):587-594. doi:10.1038/nn.2106 apa: Huxter, J., Senior, T., Allen, K., & Csicsvari, J. L. (2008). Theta phase-specific codes for two-dimensional position, trajectory and heading in the hippocampus. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.2106 chicago: Huxter, John, Timothy Senior, Kevin Allen, and Jozsef L Csicsvari. “Theta Phase-Specific Codes for Two-Dimensional Position, Trajectory and Heading in the Hippocampus.” Nature Neuroscience. Nature Publishing Group, 2008. https://doi.org/10.1038/nn.2106. ieee: J. Huxter, T. Senior, K. Allen, and J. L. Csicsvari, “Theta phase-specific codes for two-dimensional position, trajectory and heading in the hippocampus,” Nature Neuroscience, vol. 11, no. 5. Nature Publishing Group, pp. 587–594, 2008. ista: Huxter J, Senior T, Allen K, Csicsvari JL. 2008. Theta phase-specific codes for two-dimensional position, trajectory and heading in the hippocampus. Nature Neuroscience. 11(5), 587–594. mla: Huxter, John, et al. “Theta Phase-Specific Codes for Two-Dimensional Position, Trajectory and Heading in the Hippocampus.” Nature Neuroscience, vol. 11, no. 5, Nature Publishing Group, 2008, pp. 587–94, doi:10.1038/nn.2106. short: J. Huxter, T. Senior, K. Allen, J.L. Csicsvari, Nature Neuroscience 11 (2008) 587–594. date_created: 2018-12-11T12:03:44Z date_published: 2008-05-29T00:00:00Z date_updated: 2021-01-12T07:44:00Z day: '29' doi: 10.1038/nn.2106 extern: 1 intvolume: ' 11' issue: '5' month: '05' page: 587 - 594 publication: Nature Neuroscience publication_status: published publisher: Nature Publishing Group publist_id: '2869' quality_controlled: 0 status: public title: Theta phase-specific codes for two-dimensional position, trajectory and heading in the hippocampus type: journal_article volume: 11 year: '2008' ... --- _id: '3530' abstract: - lang: eng text: In the cerebral cortex, GABAergic interneurons are often regarded as fast-spiking cells. We have identified a type of slow-spiking interneuron that offers distinct contributions to network activity. “Ivy” cells, named after their dense and fine axons innervating mostly basal and oblique pyramidal cell dendrites, are more numerous than the parvalbumin-expressing basket, bistratified, or axo-axonic cells. Ivy cells express nitric oxide synthase, neuropeptide Y, and high levels of GABA(A) receptor alpha 1 subunit; they discharge at a low frequency with wide spikes in vivo, yet are distinctively phase-locked to behaviorally relevant network rhythms including theta, gamma, and ripple oscillations. Paired recordings in vitro showed that Ivy cells receive depressing EPSPs from pyramidal cells, which in turn receive slowly rising and decaying inhibitory input from Ivy cells. In contrast to fast-spiking interneurons operating with millisecond precision, the highly abundant Ivy cells express presynaptically acting neuromodulators and regulate the excitability of pyramidal cell dendrites through slowly rising and decaying GABAergic inputs. author: - first_name: Pablo full_name: Fuentealba,Pablo last_name: Fuentealba - first_name: Rahima full_name: Begum,Rahima last_name: Begum - first_name: Marco full_name: Capogna,Marco last_name: Capogna - first_name: Shozo full_name: Jinno,Shozo last_name: Jinno - first_name: Laszlo full_name: Marton,Laszlo F last_name: Marton - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Alex full_name: Thomson,Alex last_name: Thomson - first_name: Péter full_name: Somogyi, Péter last_name: Somogyi - first_name: Thomas full_name: Klausberger,Thomas last_name: Klausberger citation: ama: 'Fuentealba P, Begum R, Capogna M, et al. Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity. Neuron. 2008;57(6):917-929. doi:10.1016/j.neuron.2008.01.034' apa: 'Fuentealba, P., Begum, R., Capogna, M., Jinno, S., Marton, L., Csicsvari, J. L., … Klausberger, T. (2008). Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2008.01.034' chicago: 'Fuentealba, Pablo, Rahima Begum, Marco Capogna, Shozo Jinno, Laszlo Marton, Jozsef L Csicsvari, Alex Thomson, Péter Somogyi, and Thomas Klausberger. “Ivy Cells: A Population of Nitric-Oxide-Producing, Slow-Spiking GABAergic Neurons and Their Involvement in Hippocampal Network Activity.” Neuron. Elsevier, 2008. https://doi.org/10.1016/j.neuron.2008.01.034.' ieee: 'P. Fuentealba et al., “Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity,” Neuron, vol. 57, no. 6. Elsevier, pp. 917–929, 2008.' ista: 'Fuentealba P, Begum R, Capogna M, Jinno S, Marton L, Csicsvari JL, Thomson A, Somogyi P, Klausberger T. 2008. Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity. Neuron. 57(6), 917–929.' mla: 'Fuentealba, Pablo, et al. “Ivy Cells: A Population of Nitric-Oxide-Producing, Slow-Spiking GABAergic Neurons and Their Involvement in Hippocampal Network Activity.” Neuron, vol. 57, no. 6, Elsevier, 2008, pp. 917–29, doi:10.1016/j.neuron.2008.01.034.' short: P. Fuentealba, R. Begum, M. Capogna, S. Jinno, L. Marton, J.L. Csicsvari, A. Thomson, P. Somogyi, T. Klausberger, Neuron 57 (2008) 917–929. date_created: 2018-12-11T12:03:49Z date_published: 2008-03-27T00:00:00Z date_updated: 2021-01-12T07:44:06Z day: '27' doi: 10.1016/j.neuron.2008.01.034 extern: 1 intvolume: ' 57' issue: '6' month: '03' page: 917 - 929 publication: Neuron publication_status: published publisher: Elsevier publist_id: '2855' quality_controlled: 0 status: public title: 'Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity' type: journal_article volume: 57 year: '2008' ... --- _id: '3544' abstract: - lang: eng text: In the subthalamic nucleus (STN) of Parkinson's disease (PD) patients, a pronounced synchronization of oscillatory activity at beta frequencies (15-30 Hz) accompanies movement difficulties. Abnormal beta oscillations and motor symptoms are concomitantly and acutely suppressed by dopaminergic therapies, suggesting that these inappropriate rhythms might also emerge acutely from disrupted dopamine transmission. The neural basis of these abnormal beta oscillations is unclear, and how they might compromise information processing, or how they arise, is unknown. Using a 6-hydroxydopamine-lesioned rodent model of PD, we demonstrate that beta oscillations are inappropriately exaggerated, compared with controls, in a brain-state-dependent manner after chronic dopamine loss. Exaggerated beta oscillations are expressed at the levels of single neurons and small neuronal ensembles, and are focally present and spatially distributed within STN. They are also expressed in synchronous population activities, as evinced by oscillatory local field potentials, in STN and cortex. Excessively synchronized beta oscillations reduce the information coding capacity of STN neuronal ensembles, which may contribute to parkinsonian motor impairment. Acute disruption of dopamine transmission in control animals with antagonists of D-1/D-2 receptors did not exaggerate STN or cortical beta oscillations. Moreover, beta oscillations were not exaggerated until several days after 6-hydroxydopamine injections. Thus, contrary to predictions, abnormally amplified beta oscillations in cortico-STN circuits do not result simply from an acute absence of dopamine receptor stimulation, but are instead delayed sequelae of chronic dopamine depletion. Targeting the plastic processes underlying the delayed emergence of pathological beta oscillations after continuing dopaminergic dysfunction may offer considerable therapeutic promise. author: - first_name: Nicolas full_name: Mallet,Nicolas last_name: Mallet - first_name: Alek full_name: Pogosyan,Alek last_name: Pogosyan - first_name: Andrew full_name: Sharott,Andrew last_name: Sharott - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: John full_name: Bolam, John Paul last_name: Bolam - first_name: Peter full_name: Brown,Peter last_name: Brown - first_name: Peter full_name: Magill,Peter J last_name: Magill citation: ama: Mallet N, Pogosyan A, Sharott A, et al. Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. Journal of Neuroscience. 2008;28(18):4795-4806. doi:10.1523/JNEUROSCI.0123-08.2008 apa: Mallet, N., Pogosyan, A., Sharott, A., Csicsvari, J. L., Bolam, J., Brown, P., & Magill, P. (2008). Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0123-08.2008 chicago: Mallet, Nicolas, Alek Pogosyan, Andrew Sharott, Jozsef L Csicsvari, John Bolam, Peter Brown, and Peter Magill. “Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex.” Journal of Neuroscience. Society for Neuroscience, 2008. https://doi.org/10.1523/JNEUROSCI.0123-08.2008. ieee: N. Mallet et al., “Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex,” Journal of Neuroscience, vol. 28, no. 18. Society for Neuroscience, pp. 4795–4806, 2008. ista: Mallet N, Pogosyan A, Sharott A, Csicsvari JL, Bolam J, Brown P, Magill P. 2008. Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. Journal of Neuroscience. 28(18), 4795–4806. mla: Mallet, Nicolas, et al. “Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex.” Journal of Neuroscience, vol. 28, no. 18, Society for Neuroscience, 2008, pp. 4795–806, doi:10.1523/JNEUROSCI.0123-08.2008. short: N. Mallet, A. Pogosyan, A. Sharott, J.L. Csicsvari, J. Bolam, P. Brown, P. Magill, Journal of Neuroscience 28 (2008) 4795–4806. date_created: 2018-12-11T12:03:53Z date_published: 2008-04-30T00:00:00Z date_updated: 2021-01-12T07:44:12Z day: '30' doi: 10.1523/JNEUROSCI.0123-08.2008 extern: 1 intvolume: ' 28' issue: '18' month: '04' page: 4795 - 4806 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '2842' quality_controlled: 0 status: public title: Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex type: journal_article volume: 28 year: '2008' ... --- _id: '3523' abstract: - lang: eng text: On the linear track, the recent firing sequences of CA1 place cells recur during sharp wave/ripple patterns (SWRs) in a reverse temporal order [Foster & Wilson (2006) Nature, 440, 680-683]. We have found similar reverse-order reactivation during SWRs in open-field exploration where the firing sequence of cells varied before each SWR. Both the onset times and the firing patterns of cells showed a tendency for reversed sequences during SWRs. These effects were observed for SWRs that occurred during exploration, but not for those during longer immobility periods. Additionally, reverse reactivation was stronger when it was preceded by higher speed (> 5 cm/s) run periods. The trend for reverse-order SWR reactivation was not significantly different in familiar and novel environments, even though SWR-associated firing rates of both pyramidal cells and interneurons were reduced in novel environments as compared with familiar. During exploration-associated SWRs (eSWR) place cells retain place-selective firing [O'Neill et al. (2006) Neuron, 49, 143-155]. Here, we have shown that each cell's firing onset was more delayed and firing probability more reduced during eSWRs the further the rat was from the middle of the cell's place field; that is, cells receiving less momentary place-related excitatory drive fired later during SWR events. However, even controlling for place field distance, the recent firing of cells was still significantly correlated with SWR reactivation sequences. We therefore propose that both place-related drive and the firing history of cells contribute to reverse reactivation during eSWRs. author: - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Joseph full_name: Joseph O'Neill id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Kevin full_name: Allen, Kevin last_name: Allen - first_name: Timothy full_name: Senior,Timothy last_name: Senior citation: ama: Csicsvari JL, O’Neill J, Allen K, Senior T. Place-selective firing contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in open-field exploration. European Journal of Neuroscience. 2007;26(3):704-716. doi:10.1111/j.1460-9568.2007.05684.x apa: Csicsvari, J. L., O’Neill, J., Allen, K., & Senior, T. (2007). Place-selective firing contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in open-field exploration. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/j.1460-9568.2007.05684.x chicago: Csicsvari, Jozsef L, Joseph O’Neill, Kevin Allen, and Timothy Senior. “Place-Selective Firing Contributes to the Reverse-Order Reactivation of CA1 Pyramidal Cells during Sharp Waves in Open-Field Exploration.” European Journal of Neuroscience. Wiley-Blackwell, 2007. https://doi.org/10.1111/j.1460-9568.2007.05684.x. ieee: J. L. Csicsvari, J. O’Neill, K. Allen, and T. Senior, “Place-selective firing contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in open-field exploration,” European Journal of Neuroscience, vol. 26, no. 3. Wiley-Blackwell, pp. 704–716, 2007. ista: Csicsvari JL, O’Neill J, Allen K, Senior T. 2007. Place-selective firing contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in open-field exploration. European Journal of Neuroscience. 26(3), 704–716. mla: Csicsvari, Jozsef L., et al. “Place-Selective Firing Contributes to the Reverse-Order Reactivation of CA1 Pyramidal Cells during Sharp Waves in Open-Field Exploration.” European Journal of Neuroscience, vol. 26, no. 3, Wiley-Blackwell, 2007, pp. 704–16, doi:10.1111/j.1460-9568.2007.05684.x. short: J.L. Csicsvari, J. O’Neill, K. Allen, T. Senior, European Journal of Neuroscience 26 (2007) 704–716. date_created: 2018-12-11T12:03:46Z date_published: 2007-08-01T00:00:00Z date_updated: 2021-01-12T07:44:03Z day: '01' doi: 10.1111/j.1460-9568.2007.05684.x extern: 1 intvolume: ' 26' issue: '3' month: '08' page: 704 - 716 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '2862' quality_controlled: 0 status: public title: Place-selective firing contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in open-field exploration type: journal_article volume: 26 year: '2007' ... --- _id: '3522' abstract: - lang: eng text: We observed sharp wave/ripples (SWR) during exploration within brief (< 2.4 s) interruptions of or during theta oscillations. CA1 network responses of SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility or sleep were similar. However, neuronal activity during eSWR was location dependent, and eSWR-related firing was stronger inside the place field than outside. The eSPW-related firing increase was stronger than the baseline increase inside compared to outside, suggesting a “supralinear” summation of eSWR and place-selective inputs. Pairs of cells with similar place fields and/or correlated firing during exploration showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential activation of place cells was not required for the reactivation of waking co-firing patterns; cell pairs with symmetrical cross-correlations still showed reactivated waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing during eSWRs facilitates initial associations between cells with similar place fields that enable place-related ensemble patterns to recur during subsequent sleep-SWRs. author: - first_name: Joseph full_name: Joseph O'Neill id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Timothy full_name: Senior,Timothy last_name: Senior - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: O’Neill J, Senior T, Csicsvari JL. Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior. Neuron. 2006;49(1):143-155. doi:10.1016/j.neuron.2005.10.037 apa: O’Neill, J., Senior, T., & Csicsvari, J. L. (2006). Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2005.10.037 chicago: O’Neill, Joseph, Timothy Senior, and Jozsef L Csicsvari. “Place-Selective Firing of CA1 Pyramidal Cells during Sharp Wave/Ripple Network Patterns in Exploratory Behavior.” Neuron. Elsevier, 2006. https://doi.org/10.1016/j.neuron.2005.10.037. ieee: J. O’Neill, T. Senior, and J. L. Csicsvari, “Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior,” Neuron, vol. 49, no. 1. Elsevier, pp. 143–155, 2006. ista: O’Neill J, Senior T, Csicsvari JL. 2006. Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior. Neuron. 49(1), 143–155. mla: O’Neill, Joseph, et al. “Place-Selective Firing of CA1 Pyramidal Cells during Sharp Wave/Ripple Network Patterns in Exploratory Behavior.” Neuron, vol. 49, no. 1, Elsevier, 2006, pp. 143–55, doi:10.1016/j.neuron.2005.10.037. short: J. O’Neill, T. Senior, J.L. Csicsvari, Neuron 49 (2006) 143–155. date_created: 2018-12-11T12:03:46Z date_published: 2006-01-05T00:00:00Z date_updated: 2021-01-12T07:44:03Z day: '05' doi: 10.1016/j.neuron.2005.10.037 extern: 1 intvolume: ' 49' issue: '1' month: '01' page: 143 - 155 publication: Neuron publication_status: published publisher: Elsevier publist_id: '2863' quality_controlled: 0 status: public title: Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior type: journal_article volume: 49 year: '2006' ... --- _id: '3545' abstract: - lang: eng text: The functional organization of the basal ganglia ( BG) is often defined according to one of two opposing schemes. The first proposes multiple, essentially independent channels of information processing. The second posits convergence and lateral integration of striatal channels at the level of the globus pallidus ( GP). We tested the hypothesis that these proposed aspects of functional connectivity within the striatopallidal axis are dynamic and related to brain state. Local field potentials ( LFPs) were simultaneously recorded from multiple sites in striatum and GP in anesthetized rats during slow-wave activity( SWA) and during global activation evoked by sensory stimulation. Functional connectivity was inferred from comparative analyses of the internuclear and intranuclear coherence between bipolar derivations of LFPs. During prominent SWA, as shown in the electrocorticogram and local field potentials in the basal ganglia, intranuclear coherence, and, thus, lateral functional connectivity within striatum or globus pallidus was relatively weak. Furthermore, the temporal coupling of LFPs recorded across these two nuclei involved functional convergence at the level of GP. Global activation, indicated by a loss of SWA, was accompanied by a rapid functional reorganization of the striatopallidal axis. Prominent lateral functional connectivity developed within GP and, to a significantly more constrained spatial extent, striatum. Additionally, functional convergence on GP was no longer apparent, despite increased internuclear coherence. These data demonstrate that functional connectivity within the BG is highly dynamic and suggest that the relative expression of organizational principles, such as parallel, independent processing channels, striatopallidal convergence, and lateral integration within BG nuclei, is dependent on brain state. author: - first_name: Peter full_name: Magill,Peter J last_name: Magill - first_name: Alek full_name: Pogosyan,Alek last_name: Pogosyan - first_name: Andrew full_name: Sharott,Andrew last_name: Sharott - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: John full_name: Bolam, John Paul last_name: Bolam - first_name: Peter full_name: Brown,Peter last_name: Brown citation: ama: Magill P, Pogosyan A, Sharott A, Csicsvari JL, Bolam J, Brown P. Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo. Journal of Neuroscience. 2006;26(23):6318-6329. doi:10.1523/​JNEUROSCI.0620-06.2006 apa: Magill, P., Pogosyan, A., Sharott, A., Csicsvari, J. L., Bolam, J., & Brown, P. (2006). Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/​JNEUROSCI.0620-06.2006 chicago: Magill, Peter, Alek Pogosyan, Andrew Sharott, Jozsef L Csicsvari, John Bolam, and Peter Brown. “Changes in Functional Connectivity within the Rat Striatopallidal Axis during Global Brain Activation in Vivo.” Journal of Neuroscience. Society for Neuroscience, 2006. https://doi.org/10.1523/​JNEUROSCI.0620-06.2006. ieee: P. Magill, A. Pogosyan, A. Sharott, J. L. Csicsvari, J. Bolam, and P. Brown, “Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo,” Journal of Neuroscience, vol. 26, no. 23. Society for Neuroscience, pp. 6318–6329, 2006. ista: Magill P, Pogosyan A, Sharott A, Csicsvari JL, Bolam J, Brown P. 2006. Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo. Journal of Neuroscience. 26(23), 6318–6329. mla: Magill, Peter, et al. “Changes in Functional Connectivity within the Rat Striatopallidal Axis during Global Brain Activation in Vivo.” Journal of Neuroscience, vol. 26, no. 23, Society for Neuroscience, 2006, pp. 6318–29, doi:10.1523/​JNEUROSCI.0620-06.2006. short: P. Magill, A. Pogosyan, A. Sharott, J.L. Csicsvari, J. Bolam, P. Brown, Journal of Neuroscience 26 (2006) 6318–6329. date_created: 2018-12-11T12:03:53Z date_published: 2006-06-07T00:00:00Z date_updated: 2021-01-12T07:44:13Z day: '07' doi: 10.1523/​JNEUROSCI.0620-06.2006 extern: 1 intvolume: ' 26' issue: '23' month: '06' page: 6318 - 6329 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '2840' quality_controlled: 0 status: public title: Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo type: journal_article volume: 26 year: '2006' ... --- _id: '3443' abstract: - lang: eng text: In the hippocampal CA1 area, a relatively homogenous population of pyramidal cells is accompanied by a diversity of GABAergic interneurons. Previously, we found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum moleculare cells, innervating different domains of pyramidal cells, have distinct firing patterns during network oscillations in vivo. A second family of interneurons, expressing cholecystokinin but not parvalbumin, is known to target the same domains of pyramidal cells as do the parvalbumin cells. To test the temporal activity of these independent and parallel GABAergic inputs, we recorded the precise spike timing of identified cholecystokinin interneurons during hippocampal network oscillations in anesthetized rats and determined their molecular expression profiles and synaptic targets. The cells were cannabinoid receptor type 1 immunopositive. Contrary to the stereotyped firing of parvalbumin interneurons, cholecystokinin-expressing basket and dendrite-innervating cells discharge, on average, with 1.7 ± 2.0 Hz during high-frequency ripple oscillations in an episode-dependent manner. During theta oscillations, cholecystokinin- expressing interneurons fire with 8.8 ± 3.3 Hz at a characteristic time on the ascending phase of theta waves (155 ± 81°), when place cells start firing in freely moving animals. The firing patterns of some interneurons recorded in drug-free behaving rats were similar to cholecystokinin cells in anesthetized animals. Our results demonstrate that cholecystokinin- and parvalbumin-expressing interneurons make different contributions to network oscillations and play distinct roles in different brain states. We suggest that the specific spike timing of cholecystokinin interneurons and their sensitivity to endocannabinoids might contribute to differentiate subgroups of pyramidal cells forming neuronal assemblies, whereas parvalbumin interneurons contribute to synchronizing the entire network. Copyright © 2005 Society for Neuroscience. author: - first_name: Thomas full_name: Klausberger,Thomas last_name: Klausberger - first_name: Laszlo full_name: Marton,Laszlo F last_name: Marton - first_name: Joseph full_name: Joseph O'Neill id: 426376DC-F248-11E8-B48F-1D18A9856A87 last_name: O'Neill - first_name: Jojanneke full_name: Huck, Jojanneke H last_name: Huck - first_name: Yannis full_name: Dalezios, Yannis last_name: Dalezios - first_name: Pablo full_name: Fuentealba,Pablo last_name: Fuentealba - first_name: Wai full_name: Suen, Wai Yee last_name: Suen - first_name: Edit full_name: Papp, Edit Cs last_name: Papp - first_name: Takeshi full_name: Kaneko, Takeshi last_name: Kaneko - first_name: Masahiko full_name: Watanabe, Masahiko last_name: Watanabe - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Péter full_name: Somogyi, Péter last_name: Somogyi citation: ama: Klausberger T, Marton L, O’Neill J, et al. Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. Journal of Neuroscience. 2005;25(42):9782-9793. doi:10.1523/JNEUROSCI.3269-05.2005 apa: Klausberger, T., Marton, L., O’Neill, J., Huck, J., Dalezios, Y., Fuentealba, P., … Somogyi, P. (2005). Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.3269-05.2005 chicago: Klausberger, Thomas, Laszlo Marton, Joseph O’Neill, Jojanneke Huck, Yannis Dalezios, Pablo Fuentealba, Wai Suen, et al. “Complementary Roles of Cholecystokinin- and Parvalbumin-Expressing GABAergic Neurons in Hippocampal Network Oscillations.” Journal of Neuroscience. Society for Neuroscience, 2005. https://doi.org/10.1523/JNEUROSCI.3269-05.2005. ieee: T. Klausberger et al., “Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations,” Journal of Neuroscience, vol. 25, no. 42. Society for Neuroscience, pp. 9782–9793, 2005. ista: Klausberger T, Marton L, O’Neill J, Huck J, Dalezios Y, Fuentealba P, Suen W, Papp E, Kaneko T, Watanabe M, Csicsvari JL, Somogyi P. 2005. Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. Journal of Neuroscience. 25(42), 9782–9793. mla: Klausberger, Thomas, et al. “Complementary Roles of Cholecystokinin- and Parvalbumin-Expressing GABAergic Neurons in Hippocampal Network Oscillations.” Journal of Neuroscience, vol. 25, no. 42, Society for Neuroscience, 2005, pp. 9782–93, doi:10.1523/JNEUROSCI.3269-05.2005. short: T. Klausberger, L. Marton, J. O’Neill, J. Huck, Y. Dalezios, P. Fuentealba, W. Suen, E. Papp, T. Kaneko, M. Watanabe, J.L. Csicsvari, P. Somogyi, Journal of Neuroscience 25 (2005) 9782–9793. date_created: 2018-12-11T12:03:21Z date_published: 2005-10-19T00:00:00Z date_updated: 2021-01-12T07:43:30Z day: '19' doi: 10.1523/JNEUROSCI.3269-05.2005 extern: 1 intvolume: ' 25' issue: '42' month: '10' page: 9782 - 9793 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '2944' quality_controlled: 0 status: public title: Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations type: journal_article volume: 25 year: '2005' ... --- _id: '3536' abstract: - lang: eng text: 'Genetic engineering of the mouse brain allows investigators to address novel hypotheses in vivo. Because of the paucity of information on the network patterns of the mouse hippocampus, we investigated the electrical patterns in the behaving animal using multisite silicon probes and wire tetrodes. Theta (6-9 Hz) and gamma (40-100 Hz) oscillations were present during exploration and rapid eye movement sleep. Gamma power and theta power were comodulated and gamma power varied as a function of the theta cycle. Pyramidal cells and putative interneurons were phase-locked to theta oscillations. During immobility, consummatory behaviors and slow-wave sleep, sharp waves were present in cornu ammonis region CA1 of the hippocampus stratum radiatum associated with 140-200-Hz “ripples” in the pyramidal cell layer and population burst of CA1 neurons. In the hilus, large-amplitude “dentate spikes” occurred in association with increased discharge of hilar neurons. The amplitude of field patterns was larger in the mouse than in the rat, likely reflecting the higher neuron density in a smaller brain. We suggest that the main hippocampal network patterns are mediated by similar pathways and mechanisms in mouse and rat. ' author: - first_name: György full_name: Buzsáki, György last_name: Buzsáki - first_name: Derek full_name: Buhl, Derek L last_name: Buhl - first_name: Kenneth full_name: Harris, Kenneth D last_name: Harris - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Boldizsár full_name: Czéh, Boldizsár last_name: Czéh - first_name: Alexei full_name: Morozov, Alexei last_name: Morozov citation: ama: Buzsáki G, Buhl D, Harris K, Csicsvari JL, Czéh B, Morozov A. Hippocampal network patterns of activity in the mouse. Neuroscience. 2003;116(1):201-211. doi:10.1016/S0306-4522(02)00669-3 apa: Buzsáki, G., Buhl, D., Harris, K., Csicsvari, J. L., Czéh, B., & Morozov, A. (2003). Hippocampal network patterns of activity in the mouse. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(02)00669-3 chicago: Buzsáki, György, Derek Buhl, Kenneth Harris, Jozsef L Csicsvari, Boldizsár Czéh, and Alexei Morozov. “Hippocampal Network Patterns of Activity in the Mouse.” Neuroscience. Elsevier, 2003. https://doi.org/10.1016/S0306-4522(02)00669-3. ieee: G. Buzsáki, D. Buhl, K. Harris, J. L. Csicsvari, B. Czéh, and A. Morozov, “Hippocampal network patterns of activity in the mouse,” Neuroscience, vol. 116, no. 1. Elsevier, pp. 201–211, 2003. ista: Buzsáki G, Buhl D, Harris K, Csicsvari JL, Czéh B, Morozov A. 2003. Hippocampal network patterns of activity in the mouse. Neuroscience. 116(1), 201–211. mla: Buzsáki, György, et al. “Hippocampal Network Patterns of Activity in the Mouse.” Neuroscience, vol. 116, no. 1, Elsevier, 2003, pp. 201–11, doi:10.1016/S0306-4522(02)00669-3. short: G. Buzsáki, D. Buhl, K. Harris, J.L. Csicsvari, B. Czéh, A. Morozov, Neuroscience 116 (2003) 201–211. date_created: 2018-12-11T12:03:50Z date_published: 2003-01-15T00:00:00Z date_updated: 2021-01-12T07:44:09Z day: '15' doi: 10.1016/S0306-4522(02)00669-3 extern: 1 intvolume: ' 116' issue: '1' month: '01' page: 201 - 211 publication: Neuroscience publication_status: published publisher: Elsevier publist_id: '2849' quality_controlled: 0 status: public title: Hippocampal network patterns of activity in the mouse type: journal_article volume: 116 year: '2003' ... --- _id: '3526' abstract: - lang: eng text: Neurons can produce action potentials with high temporal precision(1). A fundamental issue is whether, and how, this capability is used in information processing. According to the `cell assembly' hypothesis, transient synchrony of anatomically distributed groups of neurons underlies processing of both external sensory input and internal cognitive mechanisms(2-4). Accordingly, neuron populations should be arranged into groups whose synchrony exceeds that predicted by common modulation by sensory input. Here we find that the spike times of hippocampal pyramidal cells can be predicted more accurately by using the spike times of simultaneously recorded neurons in addition to the animals location in space. This improvement remained when the spatial prediction was refined with a spatially dependent theta phase modulation(5-8). The time window in which spike times are best predicted from simultaneous peer activity is 10-30 ms, suggesting that cell assemblies are synchronized at this timescale. Because this temporal window matches the membrane time constant of pyramidal neurons(9), the period of the hippocampal gamma oscillation(10) and the time window for synaptic plasticity(11), we propose that cooperative activity at this timescale is optimal for information transmission and storage in cortical circuits. author: - first_name: Kenneth full_name: Harris, Kenneth D last_name: Harris - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: George full_name: Dragoi, George last_name: Dragoi - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Harris K, Csicsvari JL, Hirase H, Dragoi G, Buzsáki G. Organization of cell assemblies in the hippocampus. Nature. 2003;424(6948):552-556. doi:0.1038/nature01834 apa: Harris, K., Csicsvari, J. L., Hirase, H., Dragoi, G., & Buzsáki, G. (2003). Organization of cell assemblies in the hippocampus. Nature. Nature Publishing Group. https://doi.org/0.1038/nature01834 chicago: Harris, Kenneth, Jozsef L Csicsvari, Hajima Hirase, George Dragoi, and György Buzsáki. “Organization of Cell Assemblies in the Hippocampus.” Nature. Nature Publishing Group, 2003. https://doi.org/0.1038/nature01834. ieee: K. Harris, J. L. Csicsvari, H. Hirase, G. Dragoi, and G. Buzsáki, “Organization of cell assemblies in the hippocampus,” Nature, vol. 424, no. 6948. Nature Publishing Group, pp. 552–556, 2003. ista: Harris K, Csicsvari JL, Hirase H, Dragoi G, Buzsáki G. 2003. Organization of cell assemblies in the hippocampus. Nature. 424(6948), 552–556. mla: Harris, Kenneth, et al. “Organization of Cell Assemblies in the Hippocampus.” Nature, vol. 424, no. 6948, Nature Publishing Group, 2003, pp. 552–56, doi:0.1038/nature01834. short: K. Harris, J.L. Csicsvari, H. Hirase, G. Dragoi, G. Buzsáki, Nature 424 (2003) 552–556. date_created: 2018-12-11T12:03:47Z date_published: 2003-07-31T00:00:00Z date_updated: 2021-01-12T07:44:04Z day: '31' doi: 0.1038/nature01834 extern: 1 intvolume: ' 424' issue: '6948' month: '07' page: 552 - 556 publication: Nature publication_status: published publisher: Nature Publishing Group publist_id: '2859' quality_controlled: 0 status: public title: Organization of cell assemblies in the hippocampus type: journal_article volume: 424 year: '2003' ... --- _id: '3529' abstract: - lang: eng text: Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding of neuronal representation and storage of information. Here we describe the development of micro-machined silicon microelectrode arrays for unit and local field recordings. The two-dimensional probes with 96 or 64 recording sites provided high-density recording of unit and field activity with minimal tissue displacement or damage. The on-chip active circuit eliminated movement and other artifacts and greatly reduced the weight of the headgear. The precise geometry of the recording tips allowed for the estimation of the spatial location of the recorded neurons and for high-resolution estimation of extracellular current source density. Action potentials could be simultaneously recorded from the soma and dendrites of the same neurons. Silicon technology is a promising approach for high-density, high-resolution sampling of neuronal activity in both basic research and prosthetic devices. author: - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Darrell full_name: Henze, Darrell A last_name: Henze - first_name: Brian full_name: Jamieson, Brian G last_name: Jamieson - first_name: Kenneth full_name: Harris, Kenneth D last_name: Harris - first_name: Anton full_name: Sirota, Anton M last_name: Sirota - first_name: Peter full_name: Bartho, Peter last_name: Bartho - first_name: Kensall full_name: Wise, Kensall D last_name: Wise - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Csicsvari JL, Henze D, Jamieson B, et al. Massively parallel recording of unit and local field potentials with silicon-based electrodes. Journal of Neurophysiology. 2003;90(2):1314-1323. doi:10.1152/jn.00116.2003 apa: Csicsvari, J. L., Henze, D., Jamieson, B., Harris, K., Sirota, A., Bartho, P., … Buzsáki, G. (2003). Massively parallel recording of unit and local field potentials with silicon-based electrodes. Journal of Neurophysiology. American Physiological Society. https://doi.org/10.1152/jn.00116.2003 chicago: Csicsvari, Jozsef L, Darrell Henze, Brian Jamieson, Kenneth Harris, Anton Sirota, Peter Bartho, Kensall Wise, and György Buzsáki. “Massively Parallel Recording of Unit and Local Field Potentials with Silicon-Based Electrodes.” Journal of Neurophysiology. American Physiological Society, 2003. https://doi.org/10.1152/jn.00116.2003. ieee: J. L. Csicsvari et al., “Massively parallel recording of unit and local field potentials with silicon-based electrodes,” Journal of Neurophysiology, vol. 90, no. 2. American Physiological Society, pp. 1314–1323, 2003. ista: Csicsvari JL, Henze D, Jamieson B, Harris K, Sirota A, Bartho P, Wise K, Buzsáki G. 2003. Massively parallel recording of unit and local field potentials with silicon-based electrodes. Journal of Neurophysiology. 90(2), 1314–1323. mla: Csicsvari, Jozsef L., et al. “Massively Parallel Recording of Unit and Local Field Potentials with Silicon-Based Electrodes.” Journal of Neurophysiology, vol. 90, no. 2, American Physiological Society, 2003, pp. 1314–23, doi:10.1152/jn.00116.2003. short: J.L. Csicsvari, D. Henze, B. Jamieson, K. Harris, A. Sirota, P. Bartho, K. Wise, G. Buzsáki, Journal of Neurophysiology 90 (2003) 1314–1323. date_created: 2018-12-11T12:03:48Z date_published: 2003-08-01T00:00:00Z date_updated: 2021-01-12T07:44:05Z day: '01' doi: 10.1152/jn.00116.2003 extern: 1 intvolume: ' 90' issue: '2' month: '08' page: 1314 - 1323 publication: Journal of Neurophysiology publication_status: published publisher: American Physiological Society publist_id: '2856' quality_controlled: 0 status: public title: Massively parallel recording of unit and local field potentials with silicon-based electrodes type: journal_article volume: 90 year: '2003' ... --- _id: '3528' abstract: - lang: eng text: Gamma frequency oscillations (30-100 Hz) have been suggested to underlie various cognitive and motor functions. Here, we examine the generation of gamma oscillation currents in the hippocampus, using two-dimensional, 96-site silicon probes. Two gamma generators were identified, one in the dentate gyrus and another in the CA3-CA1 regions. The coupling strength between the two oscillators varied during both theta and nontheta states. Both pyramidal cells and interneurons were phase-locked to gamma waves. Anatomical connectivity, rather than physical distance, determined the coupling strength of the oscillating neurons. CA3 pyramidal neurons discharged CA3 and CA1 interneurons at latencies indicative of monosynaptic connections. Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which entrains the CA1 region via its interneurons. author: - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Brian full_name: Jamieson, Brian G last_name: Jamieson - first_name: Kensall full_name: Wise, Kensall D last_name: Wise - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Csicsvari JL, Jamieson B, Wise K, Buzsáki G. Mechanisms of gamma oscillations in the hippocampus of the behaving rat. Neuron. 2003;37(2):311-322. doi:10.1016/S0896-6273(02)01169-8 apa: Csicsvari, J. L., Jamieson, B., Wise, K., & Buzsáki, G. (2003). Mechanisms of gamma oscillations in the hippocampus of the behaving rat. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(02)01169-8 chicago: Csicsvari, Jozsef L, Brian Jamieson, Kensall Wise, and György Buzsáki. “Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat.” Neuron. Elsevier, 2003. https://doi.org/10.1016/S0896-6273(02)01169-8. ieee: J. L. Csicsvari, B. Jamieson, K. Wise, and G. Buzsáki, “Mechanisms of gamma oscillations in the hippocampus of the behaving rat,” Neuron, vol. 37, no. 2. Elsevier, pp. 311–322, 2003. ista: Csicsvari JL, Jamieson B, Wise K, Buzsáki G. 2003. Mechanisms of gamma oscillations in the hippocampus of the behaving rat. Neuron. 37(2), 311–322. mla: Csicsvari, Jozsef L., et al. “Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat.” Neuron, vol. 37, no. 2, Elsevier, 2003, pp. 311–22, doi:10.1016/S0896-6273(02)01169-8. short: J.L. Csicsvari, B. Jamieson, K. Wise, G. Buzsáki, Neuron 37 (2003) 311–322. date_created: 2018-12-11T12:03:48Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T07:44:05Z day: '01' doi: 10.1016/S0896-6273(02)01169-8 extern: 1 intvolume: ' 37' issue: '2' month: '01' page: 311 - 322 publication: Neuron publication_status: published publisher: Elsevier publist_id: '2857' quality_controlled: 0 status: public title: Mechanisms of gamma oscillations in the hippocampus of the behaving rat type: journal_article volume: 37 year: '2003' ... --- _id: '3543' abstract: - lang: eng text: Both neocortical and hippocampal networks organize the firing patterns of their neurons by prominent oscillations during sleep, but the functional role of these rhythms is not well understood. Here, we show a robust correlation of neuronal discharges between the somatosensory cortex and hippocampus on both slow and fine time scales in the mouse and rat. Neuronal bursts in deep cortical layers, associated with sleep spindles and delta waves/slow rhythm, effectively triggered hippocampal discharges related to fast (ripple) oscillations. We hypothesize that oscillation-mediated temporal links coordinate specific information transfer between neocortical and hippocampal cell assemblies. Such a neocortical-hippocampal interplay may be important for memory consolidation. author: - first_name: Anton full_name: Sirota, Anton M last_name: Sirota - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Derek full_name: Buhl, Derek L last_name: Buhl - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Sirota A, Csicsvari JL, Buhl D, Buzsáki G. Communication between neocortex and hippocampus during sleep in rodents. PNAS. 2003;100(4):2065-2069. doi:10.1073/pnas.0437938100 apa: Sirota, A., Csicsvari, J. L., Buhl, D., & Buzsáki, G. (2003). Communication between neocortex and hippocampus during sleep in rodents. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.0437938100 chicago: Sirota, Anton, Jozsef L Csicsvari, Derek Buhl, and György Buzsáki. “Communication between Neocortex and Hippocampus during Sleep in Rodents.” PNAS. National Academy of Sciences, 2003. https://doi.org/10.1073/pnas.0437938100. ieee: A. Sirota, J. L. Csicsvari, D. Buhl, and G. Buzsáki, “Communication between neocortex and hippocampus during sleep in rodents,” PNAS, vol. 100, no. 4. National Academy of Sciences, pp. 2065–2069, 2003. ista: Sirota A, Csicsvari JL, Buhl D, Buzsáki G. 2003. Communication between neocortex and hippocampus during sleep in rodents. PNAS. 100(4), 2065–2069. mla: Sirota, Anton, et al. “Communication between Neocortex and Hippocampus during Sleep in Rodents.” PNAS, vol. 100, no. 4, National Academy of Sciences, 2003, pp. 2065–69, doi:10.1073/pnas.0437938100. short: A. Sirota, J.L. Csicsvari, D. Buhl, G. Buzsáki, PNAS 100 (2003) 2065–2069. date_created: 2018-12-11T12:03:53Z date_published: 2003-02-18T00:00:00Z date_updated: 2021-01-12T07:44:12Z day: '18' doi: 10.1073/pnas.0437938100 extern: 1 intvolume: ' 100' issue: '4' month: '02' page: 2065 - 2069 publication: PNAS publication_status: published publisher: National Academy of Sciences publist_id: '2841' quality_controlled: 0 status: public title: Communication between neocortex and hippocampus during sleep in rodents type: journal_article volume: 100 year: '2003' ... --- _id: '3533' abstract: - lang: eng text: 'Information in neuronal networks is thought to be represented by the rate of discharge and the temporal relationship between the discharging neurons. The discharge frequency of neurons is affected by their afferents and intrinsic properties, and shows great individual variability. The temporal coordination of neurons is greatly facilitated by network oscillations. In the hippocampus, population synchrony fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase almost 10-fold during sharp wave bursts. Despite these large changes in excitability in the sub-second scale, longer-term (minute-scale) firing rates of individual neurons are relatively constant in an unchanging environment. As a result, mean hippocampal output remains stable over time. To understand the mechanisms responsible for this homeostasis, we address the following issues: (i) Can firing rates of single cells be modified? (ii) Once modified, what mechanism(s) can maintain the changes? We show that firing rates of hippocampal pyramidal cells can be altered in a novel environment and by Hebbian pairing of physiological input patterns with postsynaptic burst discharge. We also illustrate a competition between single spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold) inputs decrease the ability of strong (''teaching'') inputs to induce a burst discharge, we propose that the single spike versus burst competition presents a homeostatic regulatory mechanism to maintain synaptic strength and, consequently, firing rate in pyramidal cells.' article_processing_charge: No article_type: original author: - first_name: György full_name: Buzsáki, György last_name: Buzsáki - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: George full_name: Dragoi, George last_name: Dragoi - first_name: Kenneth full_name: Harris, Kenneth last_name: Harris - first_name: D. full_name: Henze, D. last_name: Henze - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase citation: ama: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. 2002;12(9):893-899. doi:10.1093/cercor/12.9.893 apa: Buzsáki, G., Csicsvari, J. L., Dragoi, G., Harris, K., Henze, D., & Hirase, H. (2002). Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.9.893 chicago: Buzsáki, György, Jozsef L Csicsvari, George Dragoi, Kenneth Harris, D. Henze, and Hajima Hirase. “Homeostatic Maintenance of Neuronal Excitability by Burst Discharges in Vivo.” Cerebral Cortex. Oxford University Press, 2002. https://doi.org/10.1093/cercor/12.9.893. ieee: G. Buzsáki, J. L. Csicsvari, G. Dragoi, K. Harris, D. Henze, and H. Hirase, “Homeostatic maintenance of neuronal excitability by burst discharges in vivo,” Cerebral Cortex, vol. 12, no. 9. Oxford University Press, pp. 893–899, 2002. ista: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. 2002. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. 12(9), 893–899. mla: Buzsáki, György, et al. “Homeostatic Maintenance of Neuronal Excitability by Burst Discharges in Vivo.” Cerebral Cortex, vol. 12, no. 9, Oxford University Press, 2002, pp. 893–99, doi:10.1093/cercor/12.9.893. short: G. Buzsáki, J.L. Csicsvari, G. Dragoi, K. Harris, D. Henze, H. Hirase, Cerebral Cortex 12 (2002) 893–899. date_created: 2018-12-11T12:03:50Z date_published: 2002-09-01T00:00:00Z date_updated: 2023-07-17T07:27:12Z day: '01' doi: 10.1093/cercor/12.9.893 extern: '1' external_id: pmid: - '12183388' intvolume: ' 12' issue: '9' language: - iso: eng month: '09' oa_version: None page: 893 - 899 pmid: 1 publication: Cerebral Cortex publication_identifier: issn: - 1047-3211 publication_status: published publisher: Oxford University Press publist_id: '2851' quality_controlled: '1' scopus_import: '1' status: public title: Homeostatic maintenance of neuronal excitability by burst discharges in vivo type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 12 year: '2002' ... --- _id: '3546' abstract: - lang: eng text: Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a significantly stronger relationship among local (<140 <mu>m) pyramidal neurons compared with distant (>300 mum) neurons during non-theta-associated immobility and sleep but not during theta-associated running and walking. In contrast, cross-correlation between local pyramidal cell-interneuron pairs was significantly stronger than between distant pairs during theta oscillations but were similar during non-theta-associated behaviors. We suggest that network state-dependent functional clustering of neuronal activity emerges because of the differential contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta and non-theta behaviors. article_processing_charge: No article_type: original author: - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Xavier full_name: Leinekugel, Xavier last_name: Leinekugel - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 2001;21(10). doi:10.1523/JNEUROSCI.21-10-j0003.2001 apa: Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., & Buzsáki, G. (2001). Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001 chicago: Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001. ieee: H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent states of the hippocampal network affect functional clustering of neurons,” Journal of Neuroscience, vol. 21, no. 10. Society for Neuroscience, 2001. ista: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 21(10). mla: Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” Journal of Neuroscience, vol. 21, no. 10, Society for Neuroscience, 2001, doi:10.1523/JNEUROSCI.21-10-j0003.2001. short: H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal of Neuroscience 21 (2001). date_created: 2018-12-11T12:03:54Z date_published: 2001-05-15T00:00:00Z date_updated: 2023-05-12T09:47:39Z day: '15' doi: 10.1523/JNEUROSCI.21-10-j0003.2001 extern: '1' external_id: pmid: - '11319243' intvolume: ' 21' issue: '10' language: - iso: eng main_file_link: - open_access: '1' url: https://pubmed.ncbi.nlm.nih.gov/11319243/ month: '05' oa: 1 oa_version: Published Version pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2839' quality_controlled: '1' scopus_import: '1' status: public title: Behavior-dependent states of the hippocampal network affect functional clustering of neurons type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 21 year: '2001' ... --- _id: '3540' abstract: - lang: eng text: What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Hero we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep-wake-steep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered. acknowledgement: This work was supported by National Institutes of Health Grants NS34994 and MH54671, the F. M. Kirby Foundation, the Human Frontier Science Program (X.L.), and the Uehara Memorial Foundation (H.H.). article_processing_charge: No article_type: original author: - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Xavier full_name: Leinekugel, Xavier last_name: Leinekugel - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 2001;98(16):9386-9390. doi:10.1073/pnas.161274398 apa: Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (2001). Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.161274398 chicago: Hirase, Hajima, Xavier Leinekugel, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS. National Academy of Sciences, 2001. https://doi.org/10.1073/pnas.161274398. ieee: H. Hirase, X. Leinekugel, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience,” PNAS, vol. 98, no. 16. National Academy of Sciences, pp. 9386–9390, 2001. ista: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. 2001. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 98(16), 9386–9390. mla: Hirase, Hajima, et al. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS, vol. 98, no. 16, National Academy of Sciences, 2001, pp. 9386–90, doi:10.1073/pnas.161274398. short: H. Hirase, X. Leinekugel, A. Czurkó, J.L. Csicsvari, G. Buzsáki, PNAS 98 (2001) 9386–9390. date_created: 2018-12-11T12:03:52Z date_published: 2001-07-31T00:00:00Z date_updated: 2023-05-12T10:07:41Z day: '31' doi: 10.1073/pnas.161274398 extern: '1' external_id: pmid: - '11470910' intvolume: ' 98' issue: '16' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55430/ month: '07' oa: 1 oa_version: Published Version page: 9386 - 9390 pmid: 1 publication: PNAS publication_identifier: issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences publist_id: '2846' quality_controlled: '1' scopus_import: '1' status: public title: Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 98 year: '2001' ... --- _id: '3517' abstract: - lang: eng text: 'A modular multichannel microdrive (''hyperdrive'') is described. The microdrive uses printed circuit board technology and flexible fused silica capillaries. The modular design allows for the fabrication of 4-32 independently movable electrodes or `tetrodes''. The drives are re-usable and re-loading the drive with electrodes is simple. ' article_processing_charge: No article_type: original author: - first_name: Imre full_name: Szabo, Imre last_name: Szabo - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Xavier full_name: Leinekugel, Xavier last_name: Leinekugel - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. The application of printed circuit board technology for fabrication of multi-channel micro-drives. Journal of Neuroscience Methods. 2001;105(1):105-110. doi:10.1016/S0165-0270(00)00362-9 apa: Szabo, I., Czurkó, A., Csicsvari, J. L., Hirase, H., Leinekugel, X., & Buzsáki, G. (2001). The application of printed circuit board technology for fabrication of multi-channel micro-drives. Journal of Neuroscience Methods. Elsevier. https://doi.org/10.1016/S0165-0270(00)00362-9 chicago: Szabo, Imre, András Czurkó, Jozsef L Csicsvari, Hajima Hirase, Xavier Leinekugel, and György Buzsáki. “The Application of Printed Circuit Board Technology for Fabrication of Multi-Channel Micro-Drives.” Journal of Neuroscience Methods. Elsevier, 2001. https://doi.org/10.1016/S0165-0270(00)00362-9. ieee: I. Szabo, A. Czurkó, J. L. Csicsvari, H. Hirase, X. Leinekugel, and G. Buzsáki, “The application of printed circuit board technology for fabrication of multi-channel micro-drives,” Journal of Neuroscience Methods, vol. 105, no. 1. Elsevier, pp. 105–110, 2001. ista: Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. 2001. The application of printed circuit board technology for fabrication of multi-channel micro-drives. Journal of Neuroscience Methods. 105(1), 105–110. mla: Szabo, Imre, et al. “The Application of Printed Circuit Board Technology for Fabrication of Multi-Channel Micro-Drives.” Journal of Neuroscience Methods, vol. 105, no. 1, Elsevier, 2001, pp. 105–10, doi:10.1016/S0165-0270(00)00362-9. short: I. Szabo, A. Czurkó, J.L. Csicsvari, H. Hirase, X. Leinekugel, G. Buzsáki, Journal of Neuroscience Methods 105 (2001) 105–110. date_created: 2018-12-11T12:03:45Z date_published: 2001-01-30T00:00:00Z date_updated: 2023-05-15T10:50:39Z day: '30' doi: 10.1016/S0165-0270(00)00362-9 extern: '1' external_id: pmid: - '11166371' intvolume: ' 105' issue: '1' language: - iso: eng month: '01' oa_version: None page: 105 - 110 pmid: 1 publication: Journal of Neuroscience Methods publication_identifier: issn: - 0165-0270 publication_status: published publisher: Elsevier publist_id: '2868' quality_controlled: '1' scopus_import: '1' status: public title: The application of printed circuit board technology for fabrication of multi-channel micro-drives type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 105 year: '2001' ... --- _id: '3548' abstract: - lang: eng text: Simultaneous recording from large numbers of neurons is a prerequisite for understanding their cooperative behavior. Various recording techniques and spike separation methods are being used toward this goal. However, the error rates involved in spike separation have not yet been quantified. We studied the separation reliability of “tetrode” (4-wire electrode) recorded spikes by monitoring simultaneously from the same cell intracellularly with a glass pipette and extracellularly with a tetrode. With manual spike sorting, we found a trade-off between Type I and Type II errors, with errors typically ranging from 0 to 30% depending on the amplitude and firing pattern of the cell, the similarity of the waveshapes of neighboring neurons, and the experience of the operator. Performance using only a single wire was markedly lower, indicating the advantages of multiple-site monitoring techniques over single-wire recordings. For tetrode recordings, error rates were increased by burst activity and during periods of cellular synchrony. The lowest possible separation error rates were estimated by a search for the best ellipsoidal cluster shape. Human operator performance was significantly below the estimated optimum. Investigation of error distributions indicated that suboptimal performance was caused by inability of the operators to mark cluster boundaries accurately in a high-dimensional feature space. We therefore hypothesized that automatic spike-sorting algorithms have the potential to significantly lower error rates. Implementation of a semi-automatic classification system confirms this suggestion, reducing errors close to the estimated optimum, in the range 0-8%. acknowledgement: The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked ‘‘advertisement’ ’in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. We thank R. Bruno for performing cluster analysis and drawing our attention to the AutoClass program, M. Recce and P. Mitra for suggestions withdata analysis and comments on the manuscript, C. King, G. Dragoi, and X.Leinekugel for performing cluster analysis, and J. Hetke and K. Wise for supplying silicon probes. The data used in this paper are available on request by e-mail to G. Buzsaki. This work was supported by National Institutes of Health Grants NS-34994,413 MH-54671, and MH-12403 (to D. A. Henze) and by the Epilepsy Foundationof America (to D. A. Henze). article_processing_charge: No article_type: original author: - first_name: Kenneth full_name: Harris, Kenneth last_name: Harris - first_name: Darrell full_name: Henze, Darrell last_name: Henze - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements. Journal of Neurophysiology. 2000;84(1):401-414. doi:10.1152/jn.2000.84.1.401 apa: Harris, K., Henze, D., Csicsvari, J. L., Hirase, H., & Buzsáki, G. (2000). Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements. Journal of Neurophysiology. American Physiological Society. https://doi.org/10.1152/jn.2000.84.1.401 chicago: Harris, Kenneth, Darrell Henze, Jozsef L Csicsvari, Hajima Hirase, and György Buzsáki. “Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements.” Journal of Neurophysiology. American Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.401. ieee: K. Harris, D. Henze, J. L. Csicsvari, H. Hirase, and G. Buzsáki, “Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological Society, pp. 401–414, 2000. ista: Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. 2000. Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements. Journal of Neurophysiology. 84(1), 401–414. mla: Harris, Kenneth, et al. “Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements.” Journal of Neurophysiology, vol. 84, no. 1, American Physiological Society, 2000, pp. 401–14, doi:10.1152/jn.2000.84.1.401. short: K. Harris, D. Henze, J.L. Csicsvari, H. Hirase, G. Buzsáki, Journal of Neurophysiology 84 (2000) 401–414. date_created: 2018-12-11T12:03:54Z date_published: 2000-07-01T00:00:00Z date_updated: 2023-05-02T14:16:45Z day: '01' doi: 10.1152/jn.2000.84.1.401 extern: '1' external_id: pmid: - '10899214 ' intvolume: ' 84' issue: '1' language: - iso: eng month: '07' oa_version: None page: 401 - 414 pmid: 1 publication: Journal of Neurophysiology publication_identifier: issn: - 0022-3077 publication_status: published publisher: American Physiological Society publist_id: '2837' quality_controlled: '1' status: public title: Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 84 year: '2000' ... --- _id: '3532' abstract: - lang: eng text: Multichannel tetrode array recording in awake behaving animals provides a powerful method to record the activity of large numbers of neurons. The power of this method could be extended if further information concerning the intracellular state of the neurons could be extracted from the extracellularly recorded signals. Toward this end, we have simultaneously recorded intracellular and extracellular signals from hippocampal CA1 pyramidal cells and interneurons in the anesthetized rat. We found that several intracellular parameters can be deduced from extracellular spike waveforms. The width of the intracellular action potential is defined precisely by distinct points on the extracellular spike. Amplitude changes of the intracellular action potential are reflected by changes in the amplitude of the initial negative phase of the extracellular spike, and these amplitude changes are dependent on the state of the network. In addition, intracellular recordings from dendrites with simultaneous extracellular recordings from the soma indicate that, on average, action potentials are initiated in the perisomatic region and propagate to the dendrites at 1.68 m/s. Finally we determined that a tetrode in hippocampal area CA1 theoretically should be able to record electrical signals from similar to 1,000 neurons. Of these, 60-100 neurons should generate spikes of sufficient amplitude to be detectable from the noise and to allow for their separation using current spatial clustering methods. This theoretical maximum is in contrast to the approximately six units that are usually detected per tetrode. From this, we conclude that a large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral condition. acknowledgement: We thank M. Recce for comments on the manuscript and J. Hetke and K.Wise for supplying us with the silicon probes (1P41RR09754).This work was supported by National Institutes of Health Grants NS-34994,MH-54671, and MH-12403 (to D. A. Henze), the Epilepsy Foundation of American (D. A.Henze), and an Eotvos fellowship (Z. Borhegyi). article_processing_charge: No article_type: original author: - first_name: Darrell full_name: Henze, Darrell last_name: Henze - first_name: Zsolt full_name: Borhegyi, Zsolt last_name: Borhegyi - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Akira full_name: Mamiya, Akira last_name: Mamiya - first_name: Kenneth full_name: Harris, Kenneth last_name: Harris - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. Intracellular features predicted by extracellular recordings in the hippocampus in vivo. Journal of Neurophysiology. 2000;84(1):390-400. doi:10.1152/jn.2000.84.1.390 apa: Henze, D., Borhegyi, Z., Csicsvari, J. L., Mamiya, A., Harris, K., & Buzsáki, G. (2000). Intracellular features predicted by extracellular recordings in the hippocampus in vivo. Journal of Neurophysiology. American Physiological Society. https://doi.org/10.1152/jn.2000.84.1.390 chicago: Henze, Darrell, Zsolt Borhegyi, Jozsef L Csicsvari, Akira Mamiya, Kenneth Harris, and György Buzsáki. “Intracellular Features Predicted by Extracellular Recordings in the Hippocampus in Vivo.” Journal of Neurophysiology. American Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.390. ieee: D. Henze, Z. Borhegyi, J. L. Csicsvari, A. Mamiya, K. Harris, and G. Buzsáki, “Intracellular features predicted by extracellular recordings in the hippocampus in vivo,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological Society, pp. 390–400, 2000. ista: Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. 2000. Intracellular features predicted by extracellular recordings in the hippocampus in vivo. Journal of Neurophysiology. 84(1), 390–400. mla: Henze, Darrell, et al. “Intracellular Features Predicted by Extracellular Recordings in the Hippocampus in Vivo.” Journal of Neurophysiology, vol. 84, no. 1, American Physiological Society, 2000, pp. 390–400, doi:10.1152/jn.2000.84.1.390. short: D. Henze, Z. Borhegyi, J.L. Csicsvari, A. Mamiya, K. Harris, G. Buzsáki, Journal of Neurophysiology 84 (2000) 390–400. date_created: 2018-12-11T12:03:49Z date_published: 2000-07-01T00:00:00Z date_updated: 2023-05-02T14:31:13Z day: '01' doi: 10.1152/jn.2000.84.1.390 extern: '1' external_id: pmid: - '10899213' intvolume: ' 84' issue: '1' language: - iso: eng month: '07' oa_version: None page: 390 - 400 pmid: 1 publication: Journal of Neurophysiology publication_identifier: issn: - 0022-3077 publication_status: published publisher: American Physiological Society publist_id: '2854' quality_controlled: '1' status: public title: Intracellular features predicted by extracellular recordings in the hippocampus in vivo type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 84 year: '2000' ... --- _id: '3542' abstract: - lang: eng text: Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous recording of neuronal ensembles in the behaving rat. A nonlinear interaction among pyramidal neurons was observed during sharp wave (SPW)-related population bursts, with stronger synchrony associated with more widespread spatial coherence. SPW bursts emerged in the CA3a-b subregions and spread to CA3c before invading the CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was required to exert a detectable influence on CA1 pyramidal cells. Activity of some CA3 pyramidal neurons differentially predicted the ripple-related discharge of circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral state, the coherent discharge of a small group of CA3 cells is the primary cause of spiking activity in CA1 pyramidal neurons. article_processing_charge: No article_type: original author: - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Akira full_name: Mamiya, Akira last_name: Mamiya - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. 2000;28(2):585-594. doi:10.1016/S0896-6273(00)00135-5 apa: Csicsvari, J. L., Hirase, H., Mamiya, A., & Buzsáki, G. (2000). Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00135-5 chicago: Csicsvari, Jozsef L, Hajima Hirase, Akira Mamiya, and György Buzsáki. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population Events.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00135-5. ieee: J. L. Csicsvari, H. Hirase, A. Mamiya, and G. Buzsáki, “Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events,” Neuron, vol. 28, no. 2. Elsevier, pp. 585–594, 2000. ista: Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. 2000. Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. 28(2), 585–594. mla: Csicsvari, Jozsef L., et al. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population Events.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 585–94, doi:10.1016/S0896-6273(00)00135-5. short: J.L. Csicsvari, H. Hirase, A. Mamiya, G. Buzsáki, Neuron 28 (2000) 585–594. date_created: 2018-12-11T12:03:52Z date_published: 2000-11-01T00:00:00Z date_updated: 2023-05-02T14:26:07Z day: '01' doi: 10.1016/S0896-6273(00)00135-5 extern: '1' intvolume: ' 28' issue: '2' language: - iso: eng month: '11' oa_version: None page: 585 - 594 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier publist_id: '2843' quality_controlled: '1' status: public title: Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 28 year: '2000' ... --- _id: '3445' abstract: - lang: eng text: The medial septal region and the hippocampus are connected reciprocally via GABAergic neurons, but the physiological role of this loop is still not well understood. In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta activity and extracellular units recorded in the medial septum and diagonal band of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%) were significantly suppressed during SPWs. Most cells inhibited during SPW (80%) fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal layer theta waves. Because both SPW and the negative peak of local theta waves correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron classes, the findings indicate that the activity of medial septal neurons can be negatively (during SPW) or positively (during theta waves) correlated with the activity of hippocampal interneurons. We hypothesize that the functional coupling between medial septal neurons and hippocampal interneurons varies in a state-dependent manner. acknowledgement: This work was supported by National Institutes of Health Grants NS34994 and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and support and T. F. Freund for his comments on this manuscript. article_processing_charge: No article_type: original author: - first_name: George full_name: Dragoi, George last_name: Dragoi - first_name: Daniel full_name: Carpi, Daniel last_name: Carpi - first_name: Michael full_name: Recce, Michael last_name: Recce - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999 apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999). Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999 chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999. ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society for Neuroscience, pp. 6191–6199, 1999. ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. 19(14), 6191–6199. mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999. short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience 19 (1999) 6191–6199. date_created: 2018-12-11T12:03:22Z date_published: 1999-07-15T00:00:00Z date_updated: 2022-09-07T13:37:41Z day: '15' doi: 10.1523/JNEUROSCI.19-14-06191.1999 extern: '1' external_id: pmid: - '10407055' intvolume: ' 19' issue: '14' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/ month: '07' oa: 1 oa_version: Published Version page: 6191 - 6199 pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2942' quality_controlled: '1' scopus_import: '1' status: public title: Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 19 year: '1999' ... --- _id: '3444' abstract: - lang: eng text: This study examined intermittent, high-frequency (100-200 Hz) oscillatory patterns in the CA1 region of the hippocampus in the absence of theta activity, i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal activity was phase-locked not only to large amplitude (>7 SD from baseline) oscillatory events, which are present mainly during SPWs, but to smaller amplitude (<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple" frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz ("slow") oscillatory patterns. Fast ripple waves reversed just below the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves. These findings suggest that fast ripples emerge in the CA1 region, whereas slow (100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred to the CA1 field. article_processing_charge: No article_type: original author: - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Akira full_name: Mamiya, Akira last_name: Mamiya - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast  network  oscillations  in the  hippocampal  CA1 region of the behaving rat. Journal of Neuroscience. 1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999 apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999). Fast  network  oscillations  in the  hippocampal  CA1 region of the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999 chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György Buzsáki. “Fast  Network  Oscillations  in the  Hippocampal  CA1 Region of the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999. ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast  network  oscillations  in the  hippocampal  CA1 region of the behaving rat,” Journal of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999. ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast  network  oscillations  in the  hippocampal  CA1 region of the behaving rat. Journal of Neuroscience. 19(16). mla: Csicsvari, Jozsef L., et al. “Fast  Network  Oscillations  in the  Hippocampal  CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999. short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience 19 (1999). date_created: 2018-12-11T12:03:22Z date_published: 1999-08-15T00:00:00Z date_updated: 2022-09-07T13:41:18Z day: '15' doi: 10.1523/JNEUROSCI.19-16-j0001.1999 extern: '1' external_id: pmid: - '10436076' intvolume: ' 19' issue: '16' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/ month: '08' oa: 1 oa_version: Published Version pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2943' quality_controlled: '1' scopus_import: '1' status: public title: Fast network oscillations in the hippocampal CA1 region of the behaving rat type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 19 year: '1999' ... --- _id: '3524' abstract: - lang: eng text: We examined whether excitation and inhibition are balanced in hippocampal cortical networks. Extracellular field and single-unit activity were recorded by multiple tetrodes and multisite silicon probes to reveal the timing of the activity of hippocampal CAI pyramidal cells and classes of interneurons during theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and dendritic inhibition of pyramidal cells was deduced from the activity of interneurons in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively. int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population discharge of pyramidal cells during the theta cycle, respectively. SPW ripples were associated with a 2.5-fold net increase of excitation. The discharge frequency of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent” cells) during SPW suggesting that not all interneurons are innervated by pyramidal cells. Int(p) either fired together with (unimodal cells) or both before and after (bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum discharge probability of pyramidal neurons by 1-2 msec. Network state changes, as reflected by field activity, covaried with changes in the spike train dynamics of single cells and their interactions. Summed activity of parallel-recorded interneurons, but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse was true for the ripple cycles of SPWs. We suggest that network-driven excitability changes provide temporal windows of opportunity for single pyramidal cells to suppress, enable, or facilitate selective synaptic inputs. acknowledgement: This work was supported by National Institutes of Health Grants NS34994, MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and Ken Wise for supplying us with silicon probes. article_processing_charge: No article_type: original author: - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Akira full_name: Mamiya, Akira last_name: Mamiya - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999 apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999). Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999 chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999. ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat,” Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp. 274–287, 1999. ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. 19(1), 274–287. mla: Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999. short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience 19 (1999) 274–287. date_created: 2018-12-11T12:03:47Z date_published: 1999-01-01T00:00:00Z date_updated: 2022-09-07T10:00:45Z day: '01' doi: 10.1523/JNEUROSCI.19-01-00274.1999 extern: '1' external_id: pmid: - '9870957' intvolume: ' 19' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/ month: '01' oa: 1 oa_version: Published Version page: 274 - 287 pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2860' quality_controlled: '1' scopus_import: '1' status: public title: Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 19 year: '1999' ... --- _id: '3518' abstract: - lang: eng text: Information in neuronal networks may be represented by the spatiotemporal patterns of spikes. Here we examined the temporal coordination of pyramidal cell spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained to run in a defined position in space (running wheel) to activate a selected group of pyramidal cells. A template-matching method and a joint probability map method were used for sequence search. Repeating spike sequences in excess of chance occurrence were examined by comparing the number of repeating sequences in the original spike trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four different shuffling procedures were used to control for the population dynamics of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies were present in both the awake and sleeping animal in excess of what might be predicted by random variations. Spike sequences observed during wheel running were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave sleep. We hypothesize that the endogenously expressed spike sequences during sleep reflect reactivation of the circuitry modified by previous experience. Reactivation of acquired sequences may serve to consolidate information. acknowledgement: This work was supported by National Institutes of Health Grants NS34994 and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and Matthew Wilson for their suggestions with data analysis and comments on this manuscript. article_processing_charge: No article_type: original author: - first_name: Zoltán full_name: Nádasdy, Zoltán last_name: Nádasdy - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. 1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999 apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999). Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999 chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999. ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay and time compression of recurring spike sequences in the hippocampus,” Journal of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507, 1999. ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. 19(21), 9497–9507. mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999. short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience 19 (1999) 9497–9507. date_created: 2018-12-11T12:03:45Z date_published: 1999-11-01T00:00:00Z date_updated: 2022-09-07T12:48:08Z day: '01' doi: 10.1523/JNEUROSCI.19-21-09497.1999 extern: '1' external_id: pmid: - '10531452' intvolume: ' 19' issue: '21' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/ month: '11' oa: 1 oa_version: Published Version page: 9497 - 9507 pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2866' quality_controlled: '1' scopus_import: '1' status: public title: Replay and time compression of recurring spike sequences in the hippocampus type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 19 year: '1999' ... --- _id: '3519' abstract: - lang: eng text: 'In contrast to sensory cortical areas of the brain, the relevant physiological inputs to the hippocampus, leading to selective activation of pyramidal cells, are largely unknown. Pyramidal cells are thought to be phasically activated by spatial cues and a variety of sensory and motor stimuli. Here, we used a behavioural `space clamp'' method, which involved the confinement of the actively running animal in a defined position in space (running wheel) and kept sensory inputs constant. Twelve percent of the recorded CA1 pyramidal cells were selectively active while the rat was running in the wheel. Cell firing was specific to the direction of running and disappeared after rotating the recording apparatus. The discharge frequency of pyramidal cells and interneurons was sustained as long as the rat ran continuously in the wheel. Furthermore, the discharge frequency of pyramidal cells and interneurons increased with increasing running velocity, even though the frequency of hippocampal theta waves remained constant. The discharge frequency of some `wheel-related'' pyramidal cells could increase more than 10-fold between 10 and 100 cm/s, whereas the firing rate of `non-wheel'' cells remained constantly low. We hypothesize that: (i) a necessary condition for place-specific discharge of hippocampal pyramidal cells is the presence of theta oscillation; and (ii) relevant stimuli can tonically and selectively activate hippocampal pyramidal cells as long as theta activity is present.' acknowledgement: We thank M. Recce for continuous support, A. Berthoz for advice, K. Moorefor his participation in the early stages of the experiments, J. Lee for helpand C. King for his comments on the manuscript. This work was supportedby NIH (NS34994, MH54671), the Human Frontier Science Program (H.H.),the Hungarian Eo ̈tvo ̈s State Fellowship (A.C.) and the Soros Foundation (A.C.) article_processing_charge: No article_type: original author: - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. Sustained activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel.’ European Journal of Neuroscience. 1999;11(1):344-352. doi:10.1046/j.1460-9568.1999.00446.x apa: Czurkó, A., Hirase, H., Csicsvari, J. L., & Buzsáki, G. (1999). Sustained activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel.’ European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00446.x chicago: Czurkó, András, Hajima Hirase, Jozsef L Csicsvari, and György Buzsáki. “Sustained Activation of Hippocampal Pyramidal Cells by ‘space Clamping’’ in a Running Wheel.’” European Journal of Neuroscience. Wiley-Blackwell, 1999. https://doi.org/10.1046/j.1460-9568.1999.00446.x. ieee: A. Czurkó, H. Hirase, J. L. Csicsvari, and G. Buzsáki, “Sustained activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel,’” European Journal of Neuroscience, vol. 11, no. 1. Wiley-Blackwell, pp. 344–352, 1999. ista: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. 1999. Sustained activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel’. European Journal of Neuroscience. 11(1), 344–352. mla: Czurkó, András, et al. “Sustained Activation of Hippocampal Pyramidal Cells by ‘space Clamping’’ in a Running Wheel.’” European Journal of Neuroscience, vol. 11, no. 1, Wiley-Blackwell, 1999, pp. 344–52, doi:10.1046/j.1460-9568.1999.00446.x. short: A. Czurkó, H. Hirase, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience 11 (1999) 344–352. date_created: 2018-12-11T12:03:45Z date_published: 1999-01-01T00:00:00Z date_updated: 2022-09-07T13:09:08Z day: '01' doi: 10.1046/j.1460-9568.1999.00446.x extern: '1' external_id: pmid: - '9987037' intvolume: ' 11' issue: '1' language: - iso: eng month: '01' oa_version: None page: 344 - 352 pmid: 1 publication: European Journal of Neuroscience publication_identifier: issn: - 0953-816X publication_status: published publisher: Wiley-Blackwell publist_id: '2867' quality_controlled: '1' scopus_import: '1' status: public title: Sustained activation of hippocampal pyramidal cells by ‘space clamping' in a running wheel type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 11 year: '1999' ... --- _id: '3539' abstract: - lang: eng text: In the hippocampus, spatial representation of the environment has been suggested to be coded by either the firing rate of pyramidal cell assemblies or the relative timing of the action potentials during the theta EEG cycle. Here, we used a behavioural `space clamp' method, which involved the confinement of the actively running animal in a defined position in space (running wheel) to examine how `spatial' and other inputs affect firing rate and timing of hippocampal CA1 pyramidal cells and interneurons. Nineteen per cent of the recorded CA1 pyramidal cells were selectively active while the rat was running in the wheel in a given direction ('wheel' cells). Spatial rotation of the apparatus showed that selective discharge of pyramidal cells in the wheel was under the combined influence of distal and apparatus cues. During steady running, both discharge rate and theta phase were constant. Rotation of the wheel apparatus resulted in a shift of both firing rate and preferred theta phase. The discharge frequency of `wheel' cells increased threefold (on average) with increasing running velocity. In contrast, change in running speed had relatively little effect on the theta phase-related discharge of `wheel' cells. Our findings indicate that mechanisms that regulate rate and phase of spikes are overlapping but not necessarily identical. acknowledgement: 'We thank M. Recce for his comments on the manuscript. This work wassupported by NIH (NS34994, MH54671), the Human Frontier ScienceProgram (H.H.), the EoÈtvoÈs State Fellowship (A.C.) and the Soros Foundation (A.C.) ' article_processing_charge: No article_type: original author: - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping.’ European Journal of Neuroscience. 1999;11(12):4373-4380. doi:10.1046/j.1460-9568.1999.00853.x apa: Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999). Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping.’ European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00853.x chicago: Hirase, Hajima, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal Neurons during ‘Space Clamping.’” European Journal of Neuroscience. Wiley-Blackwell, 1999. https://doi.org/10.1046/j.1460-9568.1999.00853.x. ieee: H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping,’” European Journal of Neuroscience, vol. 11, no. 12. Wiley-Blackwell, pp. 4373–4380, 1999. ista: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping’. European Journal of Neuroscience. 11(12), 4373–4380. mla: Hirase, Hajima, et al. “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal Neurons during ‘Space Clamping.’” European Journal of Neuroscience, vol. 11, no. 12, Wiley-Blackwell, 1999, pp. 4373–80, doi:10.1046/j.1460-9568.1999.00853.x. short: H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience 11 (1999) 4373–4380. date_created: 2018-12-11T12:03:51Z date_published: 1999-12-01T00:00:00Z date_updated: 2022-09-06T09:45:36Z day: '01' doi: 10.1046/j.1460-9568.1999.00853.x extern: '1' external_id: pmid: - '10594664 ' intvolume: ' 11' issue: '12' language: - iso: eng month: '12' oa_version: None page: 4373 - 4380 pmid: 1 publication: European Journal of Neuroscience publication_identifier: issn: - 0953-816X publication_status: published publisher: Wiley-Blackwell publist_id: '2845' quality_controlled: '1' scopus_import: '1' status: public title: Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping’ type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 11 year: '1999' ... --- _id: '3515' abstract: - lang: eng text: Oscillations in neuronal networks are assumed to serve various physiological functions, from coordination of motor patterns to perceptual binding of sensory information. Here, we describe an ultra-slow oscillation (0.025 Hz) in the hippocampus. Extracellular and intracellular activity was recorded from the CA1 and subicular regions in rats of the Wistar and Sprague-Dawley strains. anesthetized with urethane. in a subgroup of Wistar rats (23%), spontaneous afterdischarges (4.7 +/- 1.6 s) occurred regularly at 40.8 +/- 15.7 s. The afterdischarge was initiated by a fast increase of population synchrony (100-250 Hz oscillation; “tonic” phase), followed by large-amplitude rhythmic waves and associated action potentials at gamma and beta frequency (15-50 Hz; “clonic” phase). The afterdischarges were bilaterally synchronous and terminated relatively abruptly without post-ictal depression. Single-pulse stimulation of the commissural input could trigger afterdischarges, but only at times when they were about to occur. Commissural stimulation evoked inhibitory postsynaptic potentials in pyramidal cells. However, when the stimulus triggered an afterdischarge, the inhibitory postsynaptic potential was absent and the cells remained depolarized during most of the afterdischarge. Afterdischarges were not observed in the Sprague-Dawley rats. Long-term analysis of interneuronal activity in intact, drug-free rats also revealed periodic excitability changes in the hippocampal network at 0.025 Hz. These findings indicate the presence of an ultra-slow oscillation in the hippocampal formation. The ultra-slow clock induced afterdischarges in susceptible animals. We hypothesize that a transient failure of GABAergic inhibition in a subset of Wistar rats is responsible for the emergence of epileptiform patterns. (C) 1999 IBRO. Published by Elsevier Science Ltd. acknowledgement: This work was supported by the Academy of Finland (32391) and the NIH (NS34994, MH54671). article_processing_charge: No article_type: original author: - first_name: Markku full_name: Penttonen, Markku last_name: Penttonen - first_name: Nina full_name: Nurminen, Nina last_name: Nurminen - first_name: Riitta full_name: Miettinen, Riitta last_name: Miettinen - first_name: Jouni full_name: Sirviö, Jouni last_name: Sirviö - first_name: Darrell full_name: Henze, Darrell last_name: Henze - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Penttonen M, Nurminen N, Miettinen R, et al. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience. 1999;94(3):735-743. doi:10.1016/S0306-4522(99)00367-X apa: Penttonen, M., Nurminen, N., Miettinen, R., Sirviö, J., Henze, D., Csicsvari, J. L., & Buzsáki, G. (1999). Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(99)00367-X chicago: Penttonen, Markku, Nina Nurminen, Riitta Miettinen, Jouni Sirviö, Darrell Henze, Jozsef L Csicsvari, and György Buzsáki. “Ultra-Slow Oscillation (0.025 Hz) Triggers Hippocampal Afterdischarges in Wistar Rats.” Neuroscience. Elsevier, 1999. https://doi.org/10.1016/S0306-4522(99)00367-X. ieee: M. Penttonen et al., “Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats,” Neuroscience, vol. 94, no. 3. Elsevier, pp. 735–743, 1999. ista: Penttonen M, Nurminen N, Miettinen R, Sirviö J, Henze D, Csicsvari JL, Buzsáki G. 1999. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience. 94(3), 735–743. mla: Penttonen, Markku, et al. “Ultra-Slow Oscillation (0.025 Hz) Triggers Hippocampal Afterdischarges in Wistar Rats.” Neuroscience, vol. 94, no. 3, Elsevier, 1999, pp. 735–43, doi:10.1016/S0306-4522(99)00367-X. short: M. Penttonen, N. Nurminen, R. Miettinen, J. Sirviö, D. Henze, J.L. Csicsvari, G. Buzsáki, Neuroscience 94 (1999) 735–743. date_created: 2018-12-11T12:03:44Z date_published: 1999-10-01T00:00:00Z date_updated: 2022-09-07T13:16:01Z day: '01' doi: 10.1016/S0306-4522(99)00367-X extern: '1' external_id: pmid: - '10579564' intvolume: ' 94' issue: '3' language: - iso: eng month: '10' oa_version: None page: 735 - 743 pmid: 1 publication: Neuroscience publication_identifier: issn: - 0306-4522 publication_status: published publisher: Elsevier publist_id: '2870' quality_controlled: '1' scopus_import: '1' status: public title: Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 94 year: '1999' ... --- _id: '3521' abstract: - lang: eng text: Spike transmission probability between pyramidal cells and interneurons in the CA1 pyramidal layer was investigated in the behaving rat by the simultaneous recording of neuronal ensembles. Population synchrony was strongest during sharp wave (SPW) bursts. However, the increase was three times larger for pyramidal cells than for interneurons. The contribution of single pyramidal cells to the discharge of interneurons was often large (up to 0.6 probability), as assessed by the presence of significant (<3 ms) peaks in the cross-correlogram. Complex-spike bursts were more effective than single spikes. Single cell contribution was higher between SPW bursts than during SPWs or theta activity. Hence, single pyramidal cells can reliably discharge interneurons, and the probability of spike transmission is behavior dependent. acknowledgement: We thank C. King, R. Miles, M. Recce, and the anonymous reviewers for their constructive comments on the manuscript. This work was supported by the National Institutes of Health (NS34994, MH54671 1P41RR09754), the Human Frontier Science Program, and the Whitehall Foundation. article_processing_charge: No article_type: original author: - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: 'Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat. Neuron. 1998;21(1):179-189. doi:10.1016/S0896-6273(00)80525-5' apa: 'Csicsvari, J. L., Hirase, H., Czurkó, A., & Buzsáki, G. (1998). Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)80525-5' chicago: 'Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, and György Buzsáki. “Reliability and State Dependence of Pyramidal Cell-Interneuron Synapses in the Hippocampus: An Ensemble Approach in the Behaving Rat.” Neuron. Elsevier, 1998. https://doi.org/10.1016/S0896-6273(00)80525-5.' ieee: 'J. L. Csicsvari, H. Hirase, A. Czurkó, and G. Buzsáki, “Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat,” Neuron, vol. 21, no. 1. Elsevier, pp. 179–189, 1998.' ista: 'Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. 1998. Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat. Neuron. 21(1), 179–189.' mla: 'Csicsvari, Jozsef L., et al. “Reliability and State Dependence of Pyramidal Cell-Interneuron Synapses in the Hippocampus: An Ensemble Approach in the Behaving Rat.” Neuron, vol. 21, no. 1, Elsevier, 1998, pp. 179–89, doi:10.1016/S0896-6273(00)80525-5.' short: J.L. Csicsvari, H. Hirase, A. Czurkó, G. Buzsáki, Neuron 21 (1998) 179–189. date_created: 2018-12-11T12:03:46Z date_published: 1998-07-01T00:00:00Z date_updated: 2022-08-29T14:03:55Z day: '01' doi: 10.1016/S0896-6273(00)80525-5 extern: '1' external_id: pmid: - '9697862 ' intvolume: ' 21' issue: '1' language: - iso: eng month: '07' oa_version: None page: 179 - 189 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier publist_id: '2865' quality_controlled: '1' scopus_import: '1' status: public title: 'Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 21 year: '1998' ... --- _id: '3535' author: - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: 'Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Hippocampal pyramidal neutrons “space-clamped” in a running wheel task: Place cells or path integrators? European Journal of Neuroscience. 1998;10(Suppl. 10):9932-9932.' apa: 'Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1998). Hippocampal pyramidal neutrons “space-clamped” in a running wheel task: Place cells or path integrators? European Journal of Neuroscience. Wiley-Blackwell.' chicago: 'Hirase, Hajima, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Hippocampal Pyramidal Neutrons ‘Space-Clamped’ in a Running Wheel Task: Place Cells or Path Integrators?” European Journal of Neuroscience. Wiley-Blackwell, 1998.' ieee: 'H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Hippocampal pyramidal neutrons ‘space-clamped’ in a running wheel task: Place cells or path integrators?,” European Journal of Neuroscience, vol. 10, no. Suppl. 10. Wiley-Blackwell, pp. 9932–9932, 1998.' ista: 'Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1998. Hippocampal pyramidal neutrons “space-clamped” in a running wheel task: Place cells or path integrators? European Journal of Neuroscience. 10(Suppl. 10), 9932–9932.' mla: 'Hirase, Hajima, et al. “Hippocampal Pyramidal Neutrons ‘Space-Clamped’ in a Running Wheel Task: Place Cells or Path Integrators?” European Journal of Neuroscience, vol. 10, no. Suppl. 10, Wiley-Blackwell, 1998, pp. 9932–9932.' short: H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience 10 (1998) 9932–9932. date_created: 2018-12-11T12:03:50Z date_published: 1998-01-01T00:00:00Z date_updated: 2021-01-12T07:44:08Z day: '01' extern: 1 intvolume: ' 10' issue: Suppl. 10 month: '01' page: 9932 - 9932 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '2850' quality_controlled: 0 status: public title: 'Hippocampal pyramidal neutrons “space-clamped” in a running wheel task: Place cells or path integrators?' type: journal_article volume: 10 year: '1998' ... --- _id: '3525' author: - first_name: Zoltán full_name: Nádasdy, Zoltán last_name: Nádasdy - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Nádasdy Z, Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. Persistence and temporal compression of spike sequences during fast field oscillation in the hippocampus. European Journal of Neuroscience. 1998;10(Suppl. 10):9409-9409. apa: Nádasdy, Z., Csicsvari, J. L., Hirase, H., Czurkó, A., & Buzsáki, G. (1998). Persistence and temporal compression of spike sequences during fast field oscillation in the hippocampus. European Journal of Neuroscience. Wiley-Blackwell. chicago: Nádasdy, Zoltán, Jozsef L Csicsvari, Hajima Hirase, András Czurkó, and György Buzsáki. “Persistence and Temporal Compression of Spike Sequences during Fast Field Oscillation in the Hippocampus.” European Journal of Neuroscience. Wiley-Blackwell, 1998. ieee: Z. Nádasdy, J. L. Csicsvari, H. Hirase, A. Czurkó, and G. Buzsáki, “Persistence and temporal compression of spike sequences during fast field oscillation in the hippocampus,” European Journal of Neuroscience, vol. 10, no. Suppl. 10. Wiley-Blackwell, pp. 9409–9409, 1998. ista: Nádasdy Z, Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. 1998. Persistence and temporal compression of spike sequences during fast field oscillation in the hippocampus. European Journal of Neuroscience. 10(Suppl. 10), 9409–9409. mla: Nádasdy, Zoltán, et al. “Persistence and Temporal Compression of Spike Sequences during Fast Field Oscillation in the Hippocampus.” European Journal of Neuroscience, vol. 10, no. Suppl. 10, Wiley-Blackwell, 1998, pp. 9409–9409. short: Z. Nádasdy, J.L. Csicsvari, H. Hirase, A. Czurkó, G. Buzsáki, European Journal of Neuroscience 10 (1998) 9409–9409. date_created: 2018-12-11T12:03:47Z date_published: 1998-06-01T00:00:00Z date_updated: 2021-01-12T07:44:04Z day: '01' extern: 1 intvolume: ' 10' issue: Suppl. 10 month: '06' page: 9409 - 9409 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '2861' quality_controlled: 0 status: public title: Persistence and temporal compression of spike sequences during fast field oscillation in the hippocampus type: journal_article volume: 10 year: '1998' ... --- _id: '3527' author: - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Csicsvari JL, Czurkó A, Hirase H, Buzsáki G. Monosynaptic interactions between CA1 Pyramidal cells and interneuron in the behaving rat. European Journal of Neuroscience. 1998;10(Suppl. 10):2553-2553. apa: Csicsvari, J. L., Czurkó, A., Hirase, H., & Buzsáki, G. (1998). Monosynaptic interactions between CA1 Pyramidal cells and interneuron in the behaving rat. European Journal of Neuroscience. Wiley-Blackwell. chicago: Csicsvari, Jozsef L, András Czurkó, Hajima Hirase, and György Buzsáki. “Monosynaptic Interactions between CA1 Pyramidal Cells and Interneuron in the Behaving Rat.” European Journal of Neuroscience. Wiley-Blackwell, 1998. ieee: J. L. Csicsvari, A. Czurkó, H. Hirase, and G. Buzsáki, “Monosynaptic interactions between CA1 Pyramidal cells and interneuron in the behaving rat,” European Journal of Neuroscience, vol. 10, no. Suppl. 10. Wiley-Blackwell, pp. 2553–2553, 1998. ista: Csicsvari JL, Czurkó A, Hirase H, Buzsáki G. 1998. Monosynaptic interactions between CA1 Pyramidal cells and interneuron in the behaving rat. European Journal of Neuroscience. 10(Suppl. 10), 2553–2553. mla: Csicsvari, Jozsef L., et al. “Monosynaptic Interactions between CA1 Pyramidal Cells and Interneuron in the Behaving Rat.” European Journal of Neuroscience, vol. 10, no. Suppl. 10, Wiley-Blackwell, 1998, pp. 2553–2553. short: J.L. Csicsvari, A. Czurkó, H. Hirase, G. Buzsáki, European Journal of Neuroscience 10 (1998) 2553–2553. date_created: 2018-12-11T12:03:48Z date_published: 1998-06-01T00:00:00Z date_updated: 2021-01-12T07:44:05Z day: '01' extern: 1 intvolume: ' 10' issue: Suppl. 10 month: '06' page: 2553 - 2553 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '2858' quality_controlled: 0 status: public title: Monosynaptic interactions between CA1 Pyramidal cells and interneuron in the behaving rat type: journal_article volume: 10 year: '1998' ... --- _id: '3541' abstract: - lang: eng text: 'The contribution of the various hippocampal regions to the maintenance of epileptic activity, induced by stimulation of the perforant path or commissural system, was examined in the awake rat. Combination of multiple-site recordings with silicon probes, current source density analysis and unit recordings allowed for a high spatial resolution of the field events. Following perforant path stimulation, seizures began in the dentate gyrus, followed by events in the CA3-CA1 regions. After commissural stimulation, rhythmic bursts in the CA3-CA1 circuitry preceded the activation of the dentate gyrus. Correlation of events in the different subregions indicated that the sustained rhythmic afterdischarge (2-6 Hz) could not be explained by a cycle-by-cycle excitation of principal cell populations in the hippocampal-entorhinal loop. The primary afterdischarge always terminated in the CA1 region, followed by the dentate gyrus, CA3 region and the entorhinal cortex. The duration and pattern of the hippocampal afterdischarge was essentially unaffected by removal of the entorhinal cortex. The emergence of large population spike bursts coincided with a decreased discharge of interneurons in both CAI and hilar regions. The majority of hilar interneurons displayed a strong amplitude decrement prior to the onset of population spike phase of the afterdischarge. These findings suggest that (i) afterdischarges can independently arise in the CA3-CA1 and entorhinal-dentate gyrus circuitries, (ii) reverberation of excitation in the hippocampal-entorhinal loop is not critical for the maintenance of afterdischarges and (iii) decreased activity of the interneuronal network may release population bursting of principal cells. ' acknowledgement: We thank K. Wise and J. Hetke for providing us the silicon probes, J. J. Chrobak, S. L-W. Leung, G. G. Somjen and R. D. Traub for their comments on the manuscript. This work was supported by NINDS (NS34994; 1P41RR09754; NS33310) and the Whitehall Foundation. M. Penttonen was a visiting scholar at Rutgers University, supported by the Finnish Academy of Sciences and the A. I. Virtanen Institute. article_processing_charge: No article_type: original author: - first_name: Anatol full_name: Bragin, Anatol last_name: Bragin - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Markku full_name: Penttonen, Markku last_name: Penttonen - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: 'Bragin A, Csicsvari JL, Penttonen M, Buzsáki G. Epileptic afterdischarge in the hippocampal-entorhinal system: Current source density and unit studies. Neuroscience. 1997;76(4):1187-1203. doi:10.1016/S0306-4522(96)00446-0' apa: 'Bragin, A., Csicsvari, J. L., Penttonen, M., & Buzsáki, G. (1997). Epileptic afterdischarge in the hippocampal-entorhinal system: Current source density and unit studies. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(96)00446-0' chicago: 'Bragin, Anatol, Jozsef L Csicsvari, Markku Penttonen, and György Buzsáki. “Epileptic Afterdischarge in the Hippocampal-Entorhinal System: Current Source Density and Unit Studies.” Neuroscience. Elsevier, 1997. https://doi.org/10.1016/S0306-4522(96)00446-0.' ieee: 'A. Bragin, J. L. Csicsvari, M. Penttonen, and G. Buzsáki, “Epileptic afterdischarge in the hippocampal-entorhinal system: Current source density and unit studies,” Neuroscience, vol. 76, no. 4. Elsevier, pp. 1187–1203, 1997.' ista: 'Bragin A, Csicsvari JL, Penttonen M, Buzsáki G. 1997. Epileptic afterdischarge in the hippocampal-entorhinal system: Current source density and unit studies. Neuroscience. 76(4), 1187–1203.' mla: 'Bragin, Anatol, et al. “Epileptic Afterdischarge in the Hippocampal-Entorhinal System: Current Source Density and Unit Studies.” Neuroscience, vol. 76, no. 4, Elsevier, 1997, pp. 1187–203, doi:10.1016/S0306-4522(96)00446-0.' short: A. Bragin, J.L. Csicsvari, M. Penttonen, G. Buzsáki, Neuroscience 76 (1997) 1187–1203. date_created: 2018-12-11T12:03:52Z date_published: 1997-01-15T00:00:00Z date_updated: 2022-08-19T11:53:06Z day: '15' doi: 10.1016/S0306-4522(96)00446-0 extern: '1' external_id: pmid: - '9027878' intvolume: ' 76' issue: '4' language: - iso: eng month: '01' oa_version: None page: 1187 - 1203 pmid: 1 publication: Neuroscience publication_identifier: issn: - 0306-4522 publication_status: published publisher: Elsevier publist_id: '2844' quality_controlled: '1' status: public title: 'Epileptic afterdischarge in the hippocampal-entorhinal system: Current source density and unit studies' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 76 year: '1997' ... --- _id: '3446' abstract: - lang: eng text: An effective character recognition procedure implemented on a new type of hardware system and using a new architecture called CNND is proposed. This CNND contains one or more analog cellular neural networks (CNNs) and some digital logic, combining the advantages of the fast analog CNN signal processing and the fast and easy decision capability of digital logic. It is shown that the CNND system can be used for recognition of multifont printed or handwritten characters and could recognize 100,000 char/s with a recognition rate of more than 95%. The more advantage of the system over competing types is that there is not an extra feature extraction procedure implemented in slow hardware article_processing_charge: No article_type: original author: - first_name: Tamas full_name: Sziranyi, Tamas last_name: Sziranyi - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: 'Sziranyi T, Csicsvari JL. High-speed character recognition using a dual cellular neural network architecture (CNND). IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing. 1993;40(3):223-231. doi:10.1109/82.222823' apa: 'Sziranyi, T., & Csicsvari, J. L. (1993). High-speed character recognition using a dual cellular neural network architecture (CNND). IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing. IEEE. https://doi.org/10.1109/82.222823' chicago: 'Sziranyi, Tamas, and Jozsef L Csicsvari. “High-Speed Character Recognition Using a Dual Cellular Neural Network Architecture (CNND).” IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing. IEEE, 1993. https://doi.org/10.1109/82.222823.' ieee: 'T. Sziranyi and J. L. Csicsvari, “High-speed character recognition using a dual cellular neural network architecture (CNND),” IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing, vol. 40, no. 3. IEEE, pp. 223–231, 1993.' ista: 'Sziranyi T, Csicsvari JL. 1993. High-speed character recognition using a dual cellular neural network architecture (CNND). IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing. 40(3), 223–231.' mla: 'Sziranyi, Tamas, and Jozsef L. Csicsvari. “High-Speed Character Recognition Using a Dual Cellular Neural Network Architecture (CNND).” IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing, vol. 40, no. 3, IEEE, 1993, pp. 223–31, doi:10.1109/82.222823.' short: 'T. Sziranyi, J.L. Csicsvari, IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing 40 (1993) 223–231.' date_created: 2018-12-11T12:03:22Z date_published: 1993-03-01T00:00:00Z date_updated: 2022-03-30T14:44:44Z day: '01' doi: 10.1109/82.222823 extern: '1' intvolume: ' 40' issue: '3' language: - iso: eng main_file_link: - url: https://ieeexplore.ieee.org/document/222823 month: '03' oa_version: None page: 223 - 231 publication: 'IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing' publication_identifier: issn: - 1057-7130 publication_status: published publisher: IEEE publist_id: '2941' quality_controlled: '1' scopus_import: '1' status: public title: High-speed character recognition using a dual cellular neural network architecture (CNND) type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 40 year: '1993' ...