---
_id: '14314'
abstract:
- lang: eng
text: The execution of cognitive functions requires coordinated circuit activity
across different brain areas that involves the associated firing of neuronal assemblies.
Here, we tested the circuit mechanism behind assembly interactions between the
hippocampus and the medial prefrontal cortex (mPFC) of adult rats by recording
neuronal populations during a rule-switching task. We identified functionally
coupled CA1-mPFC cells that synchronized their activity beyond that expected from
common spatial coding or oscillatory firing. When such cell pairs fired together,
the mPFC cell strongly phase locked to CA1 theta oscillations and maintained consistent
theta firing phases, independent of the theta timing of their CA1 counterpart.
These functionally connected CA1-mPFC cells formed interconnected assemblies.
While firing together with their CA1 assembly partners, mPFC cells fired along
specific theta sequences. Our results suggest that upregulated theta oscillatory
firing of mPFC cells can signal transient interactions with specific CA1 assemblies,
thus enabling distributed computations.
acknowledgement: We thank A. Cumpelik, H. Chiossi, and L. Bollman for comments on
an earlier version of this manuscript. This work was funded by EU-FP7 MC-ITN IN-SENS
(grant 607616).
article_number: '113015'
article_processing_charge: Yes
article_type: original
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Nardin M, Käfer K, Stella F, Csicsvari JL. Theta oscillations as a substrate
for medial prefrontal-hippocampal assembly interactions. Cell Reports.
2023;42(9). doi:10.1016/j.celrep.2023.113015
apa: Nardin, M., Käfer, K., Stella, F., & Csicsvari, J. L. (2023). Theta oscillations
as a substrate for medial prefrontal-hippocampal assembly interactions. Cell
Reports. Elsevier. https://doi.org/10.1016/j.celrep.2023.113015
chicago: Nardin, Michele, Karola Käfer, Federico Stella, and Jozsef L Csicsvari.
“Theta Oscillations as a Substrate for Medial Prefrontal-Hippocampal Assembly
Interactions.” Cell Reports. Elsevier, 2023. https://doi.org/10.1016/j.celrep.2023.113015.
ieee: M. Nardin, K. Käfer, F. Stella, and J. L. Csicsvari, “Theta oscillations as
a substrate for medial prefrontal-hippocampal assembly interactions,” Cell
Reports, vol. 42, no. 9. Elsevier, 2023.
ista: Nardin M, Käfer K, Stella F, Csicsvari JL. 2023. Theta oscillations as a substrate
for medial prefrontal-hippocampal assembly interactions. Cell Reports. 42(9),
113015.
mla: Nardin, Michele, et al. “Theta Oscillations as a Substrate for Medial Prefrontal-Hippocampal
Assembly Interactions.” Cell Reports, vol. 42, no. 9, 113015, Elsevier,
2023, doi:10.1016/j.celrep.2023.113015.
short: M. Nardin, K. Käfer, F. Stella, J.L. Csicsvari, Cell Reports 42 (2023).
date_created: 2023-09-10T22:01:11Z
date_published: 2023-09-26T00:00:00Z
date_updated: 2023-09-15T07:14:12Z
day: '26'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.celrep.2023.113015
ec_funded: 1
external_id:
pmid:
- '37632747'
file:
- access_level: open_access
checksum: ca77a304fb813c292550b8604b0fb41d
content_type: application/pdf
creator: dernst
date_created: 2023-09-15T07:12:46Z
date_updated: 2023-09-15T07:12:46Z
file_id: '14337'
file_name: 2023_CellPress_Nardin.pdf
file_size: 4879455
relation: main_file
success: 1
file_date_updated: 2023-09-15T07:12:46Z
has_accepted_license: '1'
intvolume: ' 42'
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: Cell Reports
publication_identifier:
eissn:
- 2211-1247
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Theta oscillations as a substrate for medial prefrontal-hippocampal assembly
interactions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 42
year: '2023'
...
---
_id: '14656'
abstract:
- lang: eng
text: Although much is known about how single neurons in the hippocampus represent
an animal's position, how circuit interactions contribute to spatial coding is
less well understood. Using a novel statistical estimator and theoretical modeling,
both developed in the framework of maximum entropy models, we reveal highly structured
CA1 cell-cell interactions in male rats during open field exploration. The statistics
of these interactions depend on whether the animal is in a familiar or novel environment.
In both conditions the circuit interactions optimize the encoding of spatial information,
but for regimes that differ in the informativeness of their spatial inputs. This
structure facilitates linear decodability, making the information easy to read
out by downstream circuits. Overall, our findings suggest that the efficient coding
hypothesis is not only applicable to individual neuron properties in the sensory
periphery, but also to neural interactions in the central brain.
acknowledgement: M.N. was supported by the European Union Horizon 2020 Grant 665385.
J.C. was supported by the European Research Council Consolidator Grant 281511. G.T.
was supported by the Austrian Science Fund (FWF) Grant P34015. C.S. was supported
by an Institute of Science and Technology fellow award and by the National Science
Foundation (NSF) Award No. 1922658. We thank Peter Baracskay, Karola Kaefer, and
Hugo Malagon-Vina for the acquisition of the data. We also thank Federico Stella,
Wiktor Młynarski, Dori Derdikman, Colin Bredenberg, Roman Huszar, Heloisa Chiossi,
Lorenzo Posani, and Mohamady El-Gaby for comments on an earlier version of the manuscript.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Cristina
full_name: Savin, Cristina
id: 3933349E-F248-11E8-B48F-1D18A9856A87
last_name: Savin
citation:
ama: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1
interactions optimizes spatial coding across experience. The Journal of Neuroscience.
2023;43(48):8140-8156. doi:10.1523/JNEUROSCI.0194-23.2023
apa: Nardin, M., Csicsvari, J. L., Tkačik, G., & Savin, C. (2023). The structure
of hippocampal CA1 interactions optimizes spatial coding across experience. The
Journal of Neuroscience. Society of Neuroscience. https://doi.org/10.1523/JNEUROSCI.0194-23.2023
chicago: Nardin, Michele, Jozsef L Csicsvari, Gašper Tkačik, and Cristina Savin.
“The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across
Experience.” The Journal of Neuroscience. Society of Neuroscience, 2023.
https://doi.org/10.1523/JNEUROSCI.0194-23.2023.
ieee: M. Nardin, J. L. Csicsvari, G. Tkačik, and C. Savin, “The structure of hippocampal
CA1 interactions optimizes spatial coding across experience,” The Journal of
Neuroscience, vol. 43, no. 48. Society of Neuroscience, pp. 8140–8156, 2023.
ista: Nardin M, Csicsvari JL, Tkačik G, Savin C. 2023. The structure of hippocampal
CA1 interactions optimizes spatial coding across experience. The Journal of Neuroscience.
43(48), 8140–8156.
mla: Nardin, Michele, et al. “The Structure of Hippocampal CA1 Interactions Optimizes
Spatial Coding across Experience.” The Journal of Neuroscience, vol. 43,
no. 48, Society of Neuroscience, 2023, pp. 8140–56, doi:10.1523/JNEUROSCI.0194-23.2023.
short: M. Nardin, J.L. Csicsvari, G. Tkačik, C. Savin, The Journal of Neuroscience
43 (2023) 8140–8156.
date_created: 2023-12-10T23:00:58Z
date_published: 2023-11-29T00:00:00Z
date_updated: 2023-12-11T11:37:20Z
day: '29'
ddc:
- '570'
department:
- _id: JoCs
- _id: GaTk
doi: 10.1523/JNEUROSCI.0194-23.2023
ec_funded: 1
external_id:
pmid:
- '37758476'
file:
- access_level: closed
checksum: e2503c8f84be1050e28f64320f1d5bd2
content_type: application/pdf
creator: dernst
date_created: 2023-12-11T11:30:37Z
date_updated: 2023-12-11T11:30:37Z
embargo: 2024-06-01
embargo_to: open_access
file_id: '14674'
file_name: 2023_JourNeuroscience_Nardin.pdf
file_size: 2280632
relation: main_file
file_date_updated: 2023-12-11T11:30:37Z
has_accepted_license: '1'
intvolume: ' 43'
issue: '48'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1523/JNEUROSCI.0194-23.2023
month: '11'
oa: 1
oa_version: Published Version
page: 8140-8156
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
grant_number: P34015
name: Efficient coding with biophysical realism
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: The Journal of Neuroscience
publication_identifier:
eissn:
- 1529-2401
publication_status: published
publisher: Society of Neuroscience
quality_controlled: '1'
scopus_import: '1'
status: public
title: The structure of hippocampal CA1 interactions optimizes spatial coding across
experience
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2023'
...
---
_id: '11951'
abstract:
- lang: eng
text: The mammalian hippocampal formation (HF) plays a key role in several higher
brain functions, such as spatial coding, learning and memory. Its simple circuit
architecture is often viewed as a trisynaptic loop, processing input originating
from the superficial layers of the entorhinal cortex (EC) and sending it back
to its deeper layers. Here, we show that excitatory neurons in layer 6b of the
mouse EC project to all sub-regions comprising the HF and receive input from the
CA1, thalamus and claustrum. Furthermore, their output is characterized by unique
slow-decaying excitatory postsynaptic currents capable of driving plateau-like
potentials in their postsynaptic targets. Optogenetic inhibition of the EC-6b
pathway affects spatial coding in CA1 pyramidal neurons, while cell ablation impairs
not only acquisition of new spatial memories, but also degradation of previously
acquired ones. Our results provide evidence of a functional role for cortical
layer 6b neurons in the adult brain.
acknowledged_ssus:
- _id: Bio
- _id: SSU
acknowledgement: We thank F. Marr and A. Schlögl for technical assistance, E. Kralli-Beller
for manuscript editing, as well as C. Sommer and the Imaging and Optics Facility
of the Institute of Science and Technology Austria (ISTA) for image analysis scripts
and microscopy support. We extend our gratitude to J. Wallenschus and D. Rangel
Guerrero for technical assistance acquiring single-unit data and I. Gridchyn for
help with single-unit clustering. Finally, we also thank B. Suter for discussions,
A. Saunders, M. Jösch, and H. Monyer for critically reading earlier versions of
the manuscript, C. Petersen for sharing clearing protocols, and the Scientific Service
Units of ISTA for efficient support. This project was funded by the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
(ERC advanced grant No 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen
Forschung (Z 312-B27, Wittgenstein award for P.J. and I3600-B27 for J.G.D. and P.V.).
article_number: '4826'
article_processing_charge: No
article_type: original
author:
- first_name: Yoav
full_name: Ben Simon, Yoav
id: 43DF3136-F248-11E8-B48F-1D18A9856A87
last_name: Ben Simon
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Ben Simon Y, Käfer K, Velicky P, Csicsvari JL, Danzl JG, Jonas PM. A direct
excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes
to spatial coding and memory. Nature Communications. 2022;13. doi:10.1038/s41467-022-32559-8
apa: Ben Simon, Y., Käfer, K., Velicky, P., Csicsvari, J. L., Danzl, J. G., &
Jonas, P. M. (2022). A direct excitatory projection from entorhinal layer 6b neurons
to the hippocampus contributes to spatial coding and memory. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-022-32559-8
chicago: Ben Simon, Yoav, Karola Käfer, Philipp Velicky, Jozsef L Csicsvari, Johann
G Danzl, and Peter M Jonas. “A Direct Excitatory Projection from Entorhinal Layer
6b Neurons to the Hippocampus Contributes to Spatial Coding and Memory.” Nature
Communications. Springer Nature, 2022. https://doi.org/10.1038/s41467-022-32559-8.
ieee: Y. Ben Simon, K. Käfer, P. Velicky, J. L. Csicsvari, J. G. Danzl, and P. M.
Jonas, “A direct excitatory projection from entorhinal layer 6b neurons to the
hippocampus contributes to spatial coding and memory,” Nature Communications,
vol. 13. Springer Nature, 2022.
ista: Ben Simon Y, Käfer K, Velicky P, Csicsvari JL, Danzl JG, Jonas PM. 2022. A
direct excitatory projection from entorhinal layer 6b neurons to the hippocampus
contributes to spatial coding and memory. Nature Communications. 13, 4826.
mla: Ben Simon, Yoav, et al. “A Direct Excitatory Projection from Entorhinal Layer
6b Neurons to the Hippocampus Contributes to Spatial Coding and Memory.” Nature
Communications, vol. 13, 4826, Springer Nature, 2022, doi:10.1038/s41467-022-32559-8.
short: Y. Ben Simon, K. Käfer, P. Velicky, J.L. Csicsvari, J.G. Danzl, P.M. Jonas,
Nature Communications 13 (2022).
date_created: 2022-08-24T08:25:50Z
date_published: 2022-08-16T00:00:00Z
date_updated: 2023-08-03T13:01:19Z
day: '16'
ddc:
- '570'
department:
- _id: JoCs
- _id: PeJo
- _id: JoDa
doi: 10.1038/s41467-022-32559-8
ec_funded: 1
external_id:
isi:
- '000841396400008'
file:
- access_level: open_access
checksum: 405936d9e4d33625d80c093c9713a91f
content_type: application/pdf
creator: dernst
date_created: 2022-08-26T11:51:40Z
date_updated: 2022-08-26T11:51:40Z
file_id: '11990'
file_name: 2022_NatureCommunications_BenSimon.pdf
file_size: 5910357
relation: main_file
success: 1
file_date_updated: 2022-08-26T11:51:40Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
keyword:
- General Physics and Astronomy
- General Biochemistry
- Genetics and Molecular Biology
- General Chemistry
- Multidisciplinary
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03600
name: Optical control of synaptic function via adhesion molecules
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus
contributes to spatial coding and memory
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '10080'
abstract:
- lang: eng
text: Hippocampal and neocortical neural activity is modulated by the position of
the individual in space. While hippocampal neurons provide the basis for a spatial
map, prefrontal cortical neurons generalize over environmental features. Whether
these generalized representations result from a bidirectional interaction with,
or are mainly derived from hippocampal spatial representations is not known. By
examining simultaneously recorded hippocampal and medial prefrontal neurons, we
observed that prefrontal spatial representations show a delayed coherence with
hippocampal ones. We also identified subpopulations of cells in the hippocampus
and medial prefrontal cortex that formed functional cross-area couplings; these
resembled the optimal connections predicted by a probabilistic model of spatial
information transfer and generalization. Moreover, cross-area couplings were strongest
and had the shortest delay preceding spatial decision-making. Our results suggest
that generalized spatial coding in the medial prefrontal cortex is inherited from
spatial representations in the hippocampus, and that the routing of information
can change dynamically with behavioral demands.
acknowledgement: We thank Federico Stella for invaluable suggestions and discussions.
We thank Yosman BapatDhar and Andrea Cumpelik for comments, help and suggestions
on the exposure of the text. We thank Predrag Živadinović and Juliana Couras for
comments on the text and the figures. This work was supported by the EU-FP7 MC-ITN
IN-SENS (grant 607616).
article_processing_charge: No
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in
the prefrontal cortex is inherited from the hippocampus. bioRxiv. doi:10.1101/2021.09.30.462269
apa: Nardin, M., Käfer, K., & Csicsvari, J. L. (n.d.). The generalized spatial
representation in the prefrontal cortex is inherited from the hippocampus. bioRxiv.
Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.09.30.462269
chicago: Nardin, Michele, Karola Käfer, and Jozsef L Csicsvari. “The Generalized
Spatial Representation in the Prefrontal Cortex Is Inherited from the Hippocampus.”
BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2021.09.30.462269.
ieee: M. Nardin, K. Käfer, and J. L. Csicsvari, “The generalized spatial representation
in the prefrontal cortex is inherited from the hippocampus,” bioRxiv. Cold
Spring Harbor Laboratory.
ista: Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in
the prefrontal cortex is inherited from the hippocampus. bioRxiv, 10.1101/2021.09.30.462269.
mla: Nardin, Michele, et al. “The Generalized Spatial Representation in the Prefrontal
Cortex Is Inherited from the Hippocampus.” BioRxiv, Cold Spring Harbor
Laboratory, doi:10.1101/2021.09.30.462269.
short: M. Nardin, K. Käfer, J.L. Csicsvari, BioRxiv (n.d.).
date_created: 2021-10-04T06:28:32Z
date_published: 2021-10-02T00:00:00Z
date_updated: 2021-10-05T12:34:26Z
day: '02'
department:
- _id: GradSch
- _id: JoCs
doi: 10.1101/2021.09.30.462269
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2021.09.30.462269
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
status: public
title: The generalized spatial representation in the prefrontal cortex is inherited
from the hippocampus
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '10077'
abstract:
- lang: eng
text: Although much is known about how single neurons in the hippocampus represent
an animal’s position, how cell-cell interactions contribute to spatial coding
remains poorly understood. Using a novel statistical estimator and theoretical
modeling, both developed in the framework of maximum entropy models, we reveal
highly structured cell-to-cell interactions whose statistics depend on familiar
vs. novel environment. In both conditions the circuit interactions optimize the
encoding of spatial information, but for regimes that differ in the signal-to-noise
ratio of their spatial inputs. Moreover, the topology of the interactions facilitates
linear decodability, making the information easy to read out by downstream circuits.
These findings suggest that the efficient coding hypothesis is not applicable
only to individual neuron properties in the sensory periphery, but also to neural
interactions in the central brain.
acknowledgement: We thank Peter Baracskay, Karola Kaefer and Hugo Malagon-Vina for
the acquisition of the data. We thank Federico Stella for comments on an earlier
version of the manuscript. MN was supported by European Union Horizon 2020 grant
665385, JC was supported by European Research Council consolidator grant 281511,
GT was supported by the Austrian Science Fund (FWF) grant P34015, CS was supported
by an IST fellow grant, National Institute of Mental Health Award 1R01MH125571-01,
by the National Science Foundation under NSF Award No. 1922658 and a Google faculty
award.
article_processing_charge: No
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Cristina
full_name: Savin, Cristina
id: 3933349E-F248-11E8-B48F-1D18A9856A87
last_name: Savin
citation:
ama: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1
interactions optimizes spatial coding across experience. bioRxiv. doi:10.1101/2021.09.28.460602
apa: Nardin, M., Csicsvari, J. L., Tkačik, G., & Savin, C. (n.d.). The structure
of hippocampal CA1 interactions optimizes spatial coding across experience. bioRxiv.
Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.09.28.460602
chicago: Nardin, Michele, Jozsef L Csicsvari, Gašper Tkačik, and Cristina Savin.
“The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across
Experience.” BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2021.09.28.460602.
ieee: M. Nardin, J. L. Csicsvari, G. Tkačik, and C. Savin, “The structure of hippocampal
CA1 interactions optimizes spatial coding across experience,” bioRxiv.
Cold Spring Harbor Laboratory.
ista: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1
interactions optimizes spatial coding across experience. bioRxiv, 10.1101/2021.09.28.460602.
mla: Nardin, Michele, et al. “The Structure of Hippocampal CA1 Interactions Optimizes
Spatial Coding across Experience.” BioRxiv, Cold Spring Harbor Laboratory,
doi:10.1101/2021.09.28.460602.
short: M. Nardin, J.L. Csicsvari, G. Tkačik, C. Savin, BioRxiv (n.d.).
date_created: 2021-10-04T06:23:34Z
date_published: 2021-09-29T00:00:00Z
date_updated: 2024-03-28T23:30:16Z
day: '29'
department:
- _id: GradSch
- _id: JoCs
- _id: GaTk
doi: 10.1101/2021.09.28.460602
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2021.09.28.460602
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
grant_number: P34015
name: Efficient coding with biophysical realism
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '11932'
relation: dissertation_contains
status: public
status: public
title: The structure of hippocampal CA1 interactions optimizes spatial coding across
experience
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '7472'
abstract:
- lang: eng
text: Temporally organized reactivation of experiences during awake immobility periods
is thought to underlie cognitive processes like planning and evaluation. While
replay of trajectories is well established for the hippocampus, it is unclear
whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral
experiences in the awake state to support task execution. We simultaneously recorded
from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent
rule-switching task on a plus maze. We found that mPFC neuronal activity encoded
relative positions between the start and goal. During awake immobility periods,
the mPFC replayed temporally organized sequences of these generalized positions,
resembling entire spatial trajectories. The occurrence of mPFC trajectory replay
positively correlated with rule-switching performance. However, hippocampal and
mPFC trajectory replay occurred independently, indicating different functions.
These results demonstrate that the mPFC can replay ordered activity patterns representing
generalized locations and suggest that mPFC replay might have a role in flexible
behavior.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: We thank Todor Asenov and Thomas Menner from the Machine Shop for
the drive design and production, Hugo Malagon-Vina for assistance in maze automatization,
Jago Wallenschus for taking the images of the histology, and Federico Stella and
Juan Felipe Ramirez-Villegas for comments on an earlier version of the manuscript.
This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616 ).
article_processing_charge: No
article_type: original
author:
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Karel
full_name: Blahna, Karel
id: 3EA859AE-F248-11E8-B48F-1D18A9856A87
last_name: Blahna
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Käfer K, Nardin M, Blahna K, Csicsvari JL. Replay of behavioral sequences in
the medial prefrontal cortex during rule switching. Neuron. 2020;106(1):P154-165.e6.
doi:10.1016/j.neuron.2020.01.015
apa: Käfer, K., Nardin, M., Blahna, K., & Csicsvari, J. L. (2020). Replay of
behavioral sequences in the medial prefrontal cortex during rule switching. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2020.01.015
chicago: Käfer, Karola, Michele Nardin, Karel Blahna, and Jozsef L Csicsvari. “Replay
of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.”
Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.015.
ieee: K. Käfer, M. Nardin, K. Blahna, and J. L. Csicsvari, “Replay of behavioral
sequences in the medial prefrontal cortex during rule switching,” Neuron,
vol. 106, no. 1. Elsevier, p. P154–165.e6, 2020.
ista: Käfer K, Nardin M, Blahna K, Csicsvari JL. 2020. Replay of behavioral sequences
in the medial prefrontal cortex during rule switching. Neuron. 106(1), P154–165.e6.
mla: Käfer, Karola, et al. “Replay of Behavioral Sequences in the Medial Prefrontal
Cortex during Rule Switching.” Neuron, vol. 106, no. 1, Elsevier, 2020,
p. P154–165.e6, doi:10.1016/j.neuron.2020.01.015.
short: K. Käfer, M. Nardin, K. Blahna, J.L. Csicsvari, Neuron 106 (2020) P154–165.e6.
date_created: 2020-02-10T15:45:48Z
date_published: 2020-04-08T00:00:00Z
date_updated: 2023-08-17T14:38:02Z
day: '08'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.015
ec_funded: 1
external_id:
isi:
- '000525319300016'
pmid:
- '32032512'
intvolume: ' 106'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.01.015
month: '04'
oa: 1
oa_version: Published Version
page: P154-165.e6
pmid: 1
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/this-brain-area-helps-us-decide/
scopus_import: '1'
status: public
title: Replay of behavioral sequences in the medial prefrontal cortex during rule
switching
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...
---
_id: '7684'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Assembly-specific disruption
of hippocampal replay leads to selective memory deficit. Neuron. 2020;106(2):291-300.e6.
doi:10.1016/j.neuron.2020.01.021
apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020).
Assembly-specific disruption of hippocampal replay leads to selective memory deficit.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.01.021
chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
“Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory
Deficit.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.021.
ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Assembly-specific
disruption of hippocampal replay leads to selective memory deficit,” Neuron,
vol. 106, no. 2. Elsevier, p. 291–300.e6, 2020.
ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Assembly-specific
disruption of hippocampal replay leads to selective memory deficit. Neuron. 106(2),
291–300.e6.
mla: Gridchyn, Igor, et al. “Assembly-Specific Disruption of Hippocampal Replay
Leads to Selective Memory Deficit.” Neuron, vol. 106, no. 2, Elsevier,
2020, p. 291–300.e6, doi:10.1016/j.neuron.2020.01.021.
short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, Neuron 106 (2020)
291–300.e6.
date_created: 2020-04-26T22:00:45Z
date_published: 2020-04-22T00:00:00Z
date_updated: 2023-08-21T06:15:31Z
day: '22'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.021
ec_funded: 1
external_id:
isi:
- '000528268200013'
pmid:
- '32070475'
intvolume: ' 106'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.01.021
month: '04'
oa: 1
oa_version: Published Version
page: 291-300.e6
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_identifier:
eissn:
- '10974199'
issn:
- '08966273'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/librarian-of-memory/
scopus_import: '1'
status: public
title: Assembly-specific disruption of hippocampal replay leads to selective memory
deficit
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...
---
_id: '8740'
abstract:
- lang: eng
text: In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory
interneurons could undergo Hebbian, associative, or non-associative plasticity.
Both behavioral and learning-dependent reorganization of these connections has
also been demonstrated by measuring spike transmission probabilities in pyramidal
cell-interneuron spike cross-correlations that indicate monosynaptic connections.
Here we investigated the activity-dependent modification of these connections
during exploratory behavior in rats by optogenetically inhibiting pyramidal cell
and interneuron subpopulations. Light application and associated firing alteration
of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron
connection weights as indicated by spike transmission changes. Spike transmission
alterations were predicted by the light-mediated changes in the number of pre-
and postsynaptic spike pairing events and by firing rate changes of interneurons
but not pyramidal cells. This work demonstrates the presence of activity-dependent
associative and non-associative reorganization of pyramidal-interneuron connections
triggered by the optogenetic modification of the firing rate and spike synchrony
of cells.
acknowledgement: We thank Michele Nardin and Federico Stella for comments on an earlier
version of the manuscript. K Deisseroth for providing the pAAV-CaMKIIα::eNpHR3.0-YFP
plasmid through Addgene. E Boyden for providing AAV2/1.CaMKII::ArchT.GFP.WPRE.SV40
plasmid through Penn Vector Core. This work was supported by the Austrian Science
Fund (I02072 and I03713) and a Swiss National Science Foundation grant to PS. The
authors declare no conflicts of interest.
article_number: '61106'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Optogenetic inhibition-mediated
activity-dependent modification of CA1 pyramidal-interneuron connections during
behavior. eLife. 2020;9. doi:10.7554/eLife.61106
apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020).
Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.61106
chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
“Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron
Connections during Behavior.” ELife. eLife Sciences Publications, 2020.
https://doi.org/10.7554/eLife.61106.
ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Optogenetic
inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior,” eLife, vol. 9. eLife Sciences Publications,
2020.
ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Optogenetic inhibition-mediated
activity-dependent modification of CA1 pyramidal-interneuron connections during
behavior. eLife. 9, 61106.
mla: Gridchyn, Igor, et al. “Optogenetic Inhibition-Mediated Activity-Dependent
Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” ELife,
vol. 9, 61106, eLife Sciences Publications, 2020, doi:10.7554/eLife.61106.
short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, ELife 9 (2020).
date_created: 2020-11-08T23:01:25Z
date_published: 2020-10-05T00:00:00Z
date_updated: 2024-02-21T12:43:40Z
day: '05'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.7554/eLife.61106
external_id:
isi:
- '000584369000001'
file:
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checksum: 6a7b0543c440f4c000a1864e69377d95
content_type: application/pdf
creator: dernst
date_created: 2020-11-09T09:17:40Z
date_updated: 2020-11-09T09:17:40Z
file_id: '8749'
file_name: 2020_eLife_Gridchyn.pdf
file_size: 447669
relation: main_file
success: 1
file_date_updated: 2020-11-09T09:17:40Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 257D4372-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I2072-B27
name: Interneuron plasticity during spatial learning
- _id: 2654F984-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03713
name: Interneuro Plasticity During Spatial Learning
publication: eLife
publication_identifier:
eissn:
- 2050084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '8563'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...
---
_id: '8563'
abstract:
- lang: eng
text: "Supplementary data provided for the provided for the publication:\r\nIgor
Gridchyn , Philipp Schoenenberger , Joseph O'Neill , Jozsef Csicsvari (2020) Optogenetic
inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior. Elife."
article_processing_charge: No
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
citation:
ama: Csicsvari JL, Gridchyn I, Schönenberger P. Optogenetic alteration of hippocampal
network activity. 2020. doi:10.15479/AT:ISTA:8563
apa: Csicsvari, J. L., Gridchyn, I., & Schönenberger, P. (2020). Optogenetic
alteration of hippocampal network activity. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:8563
chicago: Csicsvari, Jozsef L, Igor Gridchyn, and Philipp Schönenberger. “Optogenetic
Alteration of Hippocampal Network Activity.” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:8563.
ieee: J. L. Csicsvari, I. Gridchyn, and P. Schönenberger, “Optogenetic alteration
of hippocampal network activity.” Institute of Science and Technology Austria,
2020.
ista: Csicsvari JL, Gridchyn I, Schönenberger P. 2020. Optogenetic alteration of
hippocampal network activity, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8563.
mla: Csicsvari, Jozsef L., et al. Optogenetic Alteration of Hippocampal Network
Activity. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8563.
short: J.L. Csicsvari, I. Gridchyn, P. Schönenberger, (2020).
contributor:
- contributor_type: project_leader
first_name: Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
date_created: 2020-09-23T14:39:54Z
date_published: 2020-10-19T00:00:00Z
date_updated: 2024-02-21T12:43:41Z
day: '19'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.15479/AT:ISTA:8563
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success: 1
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checksum: 0bfc54b7e14c0694cd081617318ba606
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: jozsef
date_created: 2020-10-19T10:12:29Z
date_updated: 2020-10-19T10:12:29Z
file_id: '8675'
file_name: redme.docx
file_size: 11648
relation: main_file
success: 1
file_date_updated: 2020-10-19T10:12:29Z
has_accepted_license: '1'
month: '10'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8740'
relation: used_in_publication
status: public
status: public
title: Optogenetic alteration of hippocampal network activity
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '6338'
abstract:
- lang: eng
text: Hippocampal activity patterns representing movement trajectories are reactivated
in immobility and sleep periods, a process associated with memory recall, consolidation,
and decision making. It is thought that only fixed, behaviorally relevant patterns
can be reactivated, which are stored across hippocampal synaptic connections.
To test whether some generalized rules govern reactivation, we examined trajectory
reactivation following non-stereotypical exploration of familiar open-field environments.
We found that random trajectories of varying lengths and timescales were reactivated,
resembling that of Brownian motion of particles. The animals’ behavioral trajectory
did not follow Brownian diffusion demonstrating that the exact behavioral experience
is not reactivated. Therefore, hippocampal circuits are able to generate random
trajectories of any recently active map by following diffusion dynamics. This
ability of hippocampal circuits to generate representations of all behavioral
outcome combinations, experienced or not, may underlie a wide variety of hippocampal-dependent
cognitive functions such as learning, generalization, and planning.
article_processing_charge: No
article_type: original
author:
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Peter
full_name: Baracskay, Peter
id: 361CC00E-F248-11E8-B48F-1D18A9856A87
last_name: Baracskay
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Stella F, Baracskay P, O’Neill J, Csicsvari JL. Hippocampal reactivation of
random trajectories resembling Brownian diffusion. Neuron. 2019;102:450-461.
doi:10.1016/j.neuron.2019.01.052
apa: Stella, F., Baracskay, P., O’Neill, J., & Csicsvari, J. L. (2019). Hippocampal
reactivation of random trajectories resembling Brownian diffusion. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2019.01.052
chicago: Stella, Federico, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari.
“Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.”
Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.01.052.
ieee: F. Stella, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Hippocampal reactivation
of random trajectories resembling Brownian diffusion,” Neuron, vol. 102.
Elsevier, pp. 450–461, 2019.
ista: Stella F, Baracskay P, O’Neill J, Csicsvari JL. 2019. Hippocampal reactivation
of random trajectories resembling Brownian diffusion. Neuron. 102, 450–461.
mla: Stella, Federico, et al. “Hippocampal Reactivation of Random Trajectories Resembling
Brownian Diffusion.” Neuron, vol. 102, Elsevier, 2019, pp. 450–61, doi:10.1016/j.neuron.2019.01.052.
short: F. Stella, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 102 (2019) 450–461.
date_created: 2019-04-17T08:28:59Z
date_published: 2019-04-17T00:00:00Z
date_updated: 2023-08-25T10:13:07Z
day: '17'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2019.01.052
ec_funded: 1
external_id:
isi:
- '000465169700017'
pmid:
- '30819547'
intvolume: ' 102'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2019.01.052
month: '04'
oa: 1
oa_version: Published Version
page: 450-461
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 2654F984-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03713
name: Interneuro Plasticity During Spatial Learning
publication: Neuron
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/memories-of-movement-are-replayed-randomly-during-sleep/
scopus_import: '1'
status: public
title: Hippocampal reactivation of random trajectories resembling Brownian diffusion
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 102
year: '2019'
...
---
_id: '5828'
abstract:
- lang: eng
text: Hippocampus is needed for both spatial working and reference memories. Here,
using a radial eight-arm maze, we examined how the combined demand on these memories
influenced CA1 place cell assemblies while reference memories were partially updated.
This was contrasted with control tasks requiring only working memory or the update
of reference memory. Reference memory update led to the reward-directed place
field shifts at newly rewarded arms and to the gradual strengthening of firing
in passes between newly rewarded arms but not between those passes that included
a familiar-rewarded arm. At the maze center, transient network synchronization
periods preferentially replayed trajectories of the next chosen arm in reference
memory tasks but the previously visited arm in the working memory task. Hence,
reference memory demand was uniquely associated with a gradual, goal novelty-related
reorganization of place cell assemblies and with trajectory replay that reflected
the animal's decision of which arm to visit next.
article_processing_charge: No
article_type: original
author:
- first_name: Haibing
full_name: Xu, Haibing
id: 310349D0-F248-11E8-B48F-1D18A9856A87
last_name: Xu
- first_name: Peter
full_name: Baracskay, Peter
id: 361CC00E-F248-11E8-B48F-1D18A9856A87
last_name: Baracskay
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Xu H, Baracskay P, O’Neill J, Csicsvari JL. Assembly responses of hippocampal
CA1 place cells predict learned behavior in goal-directed spatial tasks on the
radial eight-arm maze. Neuron. 2019;101(1):119-132.e4. doi:10.1016/j.neuron.2018.11.015
apa: Xu, H., Baracskay, P., O’Neill, J., & Csicsvari, J. L. (2019). Assembly
responses of hippocampal CA1 place cells predict learned behavior in goal-directed
spatial tasks on the radial eight-arm maze. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2018.11.015
chicago: Xu, Haibing, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari. “Assembly
Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed
Spatial Tasks on the Radial Eight-Arm Maze.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2018.11.015.
ieee: H. Xu, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Assembly responses
of hippocampal CA1 place cells predict learned behavior in goal-directed spatial
tasks on the radial eight-arm maze,” Neuron, vol. 101, no. 1. Elsevier,
p. 119–132.e4, 2019.
ista: Xu H, Baracskay P, O’Neill J, Csicsvari JL. 2019. Assembly responses of hippocampal
CA1 place cells predict learned behavior in goal-directed spatial tasks on the
radial eight-arm maze. Neuron. 101(1), 119–132.e4.
mla: Xu, Haibing, et al. “Assembly Responses of Hippocampal CA1 Place Cells Predict
Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze.”
Neuron, vol. 101, no. 1, Elsevier, 2019, p. 119–132.e4, doi:10.1016/j.neuron.2018.11.015.
short: H. Xu, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 101 (2019) 119–132.e4.
date_created: 2019-01-13T22:59:10Z
date_published: 2019-01-02T00:00:00Z
date_updated: 2023-09-07T12:06:37Z
day: '02'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2018.11.015
ec_funded: 1
external_id:
isi:
- '000454791500014'
intvolume: ' 101'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.doi.org/10.1016/j.neuron.2018.11.015
month: '01'
oa: 1
oa_version: Published Version
page: 119-132.e4
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_identifier:
issn:
- '10974199'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/reading-rats-minds/
record:
- id: '837'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Assembly responses of hippocampal CA1 place cells predict learned behavior
in goal-directed spatial tasks on the radial eight-arm maze
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 101
year: '2019'
...
---
_id: '6194'
abstract:
- lang: eng
text: Grid cells with their rigid hexagonal firing fields are thought to provide
an invariant metric to the hippocampal cognitive map, yet environmental geometrical
features have recently been shown to distort the grid structure. Given that the
hippocampal role goes beyond space, we tested the influence of nonspatial information
on the grid organization. We trained rats to daily learn three new reward locations
on a cheeseboard maze while recording from the medial entorhinal cortex and the
hippocampal CA1 region. Many grid fields moved toward goal location, leading to
long-lasting deformations of the entorhinal map. Therefore, distortions in the
grid structure contribute to goal representation during both learning and recall,
which demonstrates that grid cells participate in mnemonic coding and do not merely
provide a simple metric of space.
article_processing_charge: No
article_type: original
author:
- first_name: Charlotte N.
full_name: Boccara, Charlotte N.
id: 3FC06552-F248-11E8-B48F-1D18A9856A87
last_name: Boccara
orcid: 0000-0001-7237-5109
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. The entorhinal cognitive
map is attracted to goals. Science. 2019;363(6434):1443-1447. doi:10.1126/science.aav4837
apa: Boccara, C. N., Nardin, M., Stella, F., O’Neill, J., & Csicsvari, J. L.
(2019). The entorhinal cognitive map is attracted to goals. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.aav4837
chicago: Boccara, Charlotte N., Michele Nardin, Federico Stella, Joseph O’Neill,
and Jozsef L Csicsvari. “The Entorhinal Cognitive Map Is Attracted to Goals.”
Science. American Association for the Advancement of Science, 2019. https://doi.org/10.1126/science.aav4837.
ieee: C. N. Boccara, M. Nardin, F. Stella, J. O’Neill, and J. L. Csicsvari, “The
entorhinal cognitive map is attracted to goals,” Science, vol. 363, no.
6434. American Association for the Advancement of Science, pp. 1443–1447, 2019.
ista: Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. 2019. The entorhinal
cognitive map is attracted to goals. Science. 363(6434), 1443–1447.
mla: Boccara, Charlotte N., et al. “The Entorhinal Cognitive Map Is Attracted to
Goals.” Science, vol. 363, no. 6434, American Association for the Advancement
of Science, 2019, pp. 1443–47, doi:10.1126/science.aav4837.
short: C.N. Boccara, M. Nardin, F. Stella, J. O’Neill, J.L. Csicsvari, Science 363
(2019) 1443–1447.
date_created: 2019-04-04T08:39:30Z
date_published: 2019-03-29T00:00:00Z
date_updated: 2024-03-28T23:30:16Z
day: '29'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1126/science.aav4837
ec_funded: 1
external_id:
isi:
- '000462738000034'
file:
- access_level: open_access
checksum: 5e6b16742cde10a560cfaf2130764da1
content_type: application/pdf
creator: dernst
date_created: 2020-05-14T09:11:10Z
date_updated: 2020-07-14T12:47:23Z
file_id: '7826'
file_name: 2019_Science_Boccara.pdf
file_size: 9045923
relation: main_file
file_date_updated: 2020-07-14T12:47:23Z
has_accepted_license: '1'
intvolume: ' 363'
isi: 1
issue: '6434'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 1443-1447
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/grid-cells-create-treasure-map-in-rat-brain/
record:
- id: '6062'
relation: popular_science
status: public
- id: '11932'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: The entorhinal cognitive map is attracted to goals
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 363
year: '2019'
...
---
_id: '5949'
abstract:
- lang: eng
text: Aberrant proteostasis of protein aggregation may lead to behavior disorders
including chronic mental illnesses (CMI). Furthermore, the neuronal activity alterations
that underlie CMI are not well understood. We recorded the local field potential
and single-unit activity of the hippocampal CA1 region in vivo in rats transgenically
overexpressing the Disrupted-in-Schizophrenia 1 (DISC1) gene (tgDISC1), modeling
sporadic CMI. These tgDISC1 rats have previously been shown to exhibit DISC1 protein
aggregation, disturbances in the dopaminergic system and attention-related deficits.
Recordings were performed during exploration of familiar and novel open field
environments and during sleep, allowing investigation of neuronal abnormalities
in unconstrained behavior. Compared to controls, tgDISC1 place cells exhibited
smaller place fields and decreased speed-modulation of their firing rates, demonstrating
altered spatial coding and deficits in encoding location-independent sensory inputs.
Oscillation analyses showed that tgDISC1 pyramidal neurons had higher theta phase
locking strength during novelty, limiting their phase coding ability. However,
their mean theta phases were more variable at the population level, reducing oscillatory
network synchronization. Finally, tgDISC1 pyramidal neurons showed a lack of novelty-induced
shift in their preferred theta and gamma firing phases, indicating deficits in
coding of novel environments with oscillatory firing. By combining single cell
and neuronal population analyses, we link DISC1 protein pathology with abnormal
hippocampal neural coding and network synchrony, and thereby gain a more comprehensive
understanding of CMI mechanisms.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Hugo
full_name: Malagon-Vina, Hugo
last_name: Malagon-Vina
- first_name: Desiree
full_name: Dickerson, Desiree
id: 444EB89E-F248-11E8-B48F-1D18A9856A87
last_name: Dickerson
- first_name: Joseph
full_name: O'Neill, Joseph
last_name: O'Neill
- first_name: Svenja V.
full_name: Trossbach, Svenja V.
last_name: Trossbach
- first_name: Carsten
full_name: Korth, Carsten
last_name: Korth
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Käfer K, Malagon-Vina H, Dickerson D, et al. Disrupted-in-schizophrenia 1 overexpression
disrupts hippocampal coding and oscillatory synchronization. Hippocampus.
2019;29(9):802-816. doi:10.1002/hipo.23076
apa: Käfer, K., Malagon-Vina, H., Dickerson, D., O’Neill, J., Trossbach, S. V.,
Korth, C., & Csicsvari, J. L. (2019). Disrupted-in-schizophrenia 1 overexpression
disrupts hippocampal coding and oscillatory synchronization. Hippocampus.
Wiley. https://doi.org/10.1002/hipo.23076
chicago: Käfer, Karola, Hugo Malagon-Vina, Desiree Dickerson, Joseph O’Neill, Svenja
V. Trossbach, Carsten Korth, and Jozsef L Csicsvari. “Disrupted-in-Schizophrenia
1 Overexpression Disrupts Hippocampal Coding and Oscillatory Synchronization.”
Hippocampus. Wiley, 2019. https://doi.org/10.1002/hipo.23076.
ieee: K. Käfer et al., “Disrupted-in-schizophrenia 1 overexpression disrupts
hippocampal coding and oscillatory synchronization,” Hippocampus, vol.
29, no. 9. Wiley, pp. 802–816, 2019.
ista: Käfer K, Malagon-Vina H, Dickerson D, O’Neill J, Trossbach SV, Korth C, Csicsvari
JL. 2019. Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding
and oscillatory synchronization. Hippocampus. 29(9), 802–816.
mla: Käfer, Karola, et al. “Disrupted-in-Schizophrenia 1 Overexpression Disrupts
Hippocampal Coding and Oscillatory Synchronization.” Hippocampus, vol.
29, no. 9, Wiley, 2019, pp. 802–16, doi:10.1002/hipo.23076.
short: K. Käfer, H. Malagon-Vina, D. Dickerson, J. O’Neill, S.V. Trossbach, C. Korth,
J.L. Csicsvari, Hippocampus 29 (2019) 802–816.
date_created: 2019-02-10T22:59:18Z
date_published: 2019-09-01T00:00:00Z
date_updated: 2024-03-28T23:30:22Z
day: '01'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1002/hipo.23076
ec_funded: 1
external_id:
isi:
- '000480635400003'
file:
- access_level: open_access
checksum: 5e8de271ca04aef92a5de42d6aac4404
content_type: application/pdf
creator: dernst
date_created: 2019-02-11T10:42:51Z
date_updated: 2020-07-14T12:47:13Z
file_id: '5950'
file_name: 2019_Hippocampus_Kaefer.pdf
file_size: 2132893
relation: main_file
file_date_updated: 2020-07-14T12:47:13Z
has_accepted_license: '1'
intvolume: ' 29'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 802-816
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: Hippocampus
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '6825'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and
oscillatory synchronization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 29
year: '2019'
...
---
_id: '5914'
abstract:
- lang: eng
text: With the advent of optogenetics, it became possible to change the activity
of a targeted population of neurons in a temporally controlled manner. To combine
the advantages of 60-channel in vivo tetrode recording and laser-based optogenetics,
we have developed a closed-loop recording system that allows for the actual electrophysiological
signal to be used as a trigger for the laser light mediating the optogenetic intervention.
We have optimized the weight, size, and shape of the corresponding implant to
make it compatible with the size, force, and movements of a behaving mouse, and
we have shown that the system can efficiently block sharp wave ripple (SWR) events
using those events themselves as a trigger. To demonstrate the full potential
of the optogenetic recording system we present a pilot study addressing the contribution
of SWR events to learning in a complex behavioral task.
article_number: e0087
article_processing_charge: No
author:
- first_name: Dámaris K
full_name: Rangel Guerrero, Dámaris K
id: 4871BCE6-F248-11E8-B48F-1D18A9856A87
last_name: Rangel Guerrero
orcid: 0000-0002-8602-4374
- first_name: James G.
full_name: Donnett, James G.
last_name: Donnett
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Krisztián
full_name: Kovács, Krisztián
id: 2AB5821E-F248-11E8-B48F-1D18A9856A87
last_name: Kovács
orcid: 0000-0001-6251-1007
citation:
ama: 'Rangel Guerrero DK, Donnett JG, Csicsvari JL, Kovács K. Tetrode recording
from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop
optogenetics: A technique to study the contribution of Hippocampal SWR events
to learning. eNeuro. 2018;5(4). doi:10.1523/ENEURO.0087-18.2018'
apa: 'Rangel Guerrero, D. K., Donnett, J. G., Csicsvari, J. L., & Kovács, K.
(2018). Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation
closed-loop optogenetics: A technique to study the contribution of Hippocampal
SWR events to learning. ENeuro. Society of Neuroscience. https://doi.org/10.1523/ENEURO.0087-18.2018'
chicago: 'Rangel Guerrero, Dámaris K, James G. Donnett, Jozsef L Csicsvari, and
Krisztián Kovács. “Tetrode Recording from the Hippocampus of Behaving Mice Coupled
with Four-Point-Irradiation Closed-Loop Optogenetics: A Technique to Study the
Contribution of Hippocampal SWR Events to Learning.” ENeuro. Society of
Neuroscience, 2018. https://doi.org/10.1523/ENEURO.0087-18.2018.'
ieee: 'D. K. Rangel Guerrero, J. G. Donnett, J. L. Csicsvari, and K. Kovács, “Tetrode
recording from the hippocampus of behaving mice coupled with four-point-irradiation
closed-loop optogenetics: A technique to study the contribution of Hippocampal
SWR events to learning,” eNeuro, vol. 5, no. 4. Society of Neuroscience,
2018.'
ista: 'Rangel Guerrero DK, Donnett JG, Csicsvari JL, Kovács K. 2018. Tetrode recording
from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop
optogenetics: A technique to study the contribution of Hippocampal SWR events
to learning. eNeuro. 5(4), e0087.'
mla: 'Rangel Guerrero, Dámaris K., et al. “Tetrode Recording from the Hippocampus
of Behaving Mice Coupled with Four-Point-Irradiation Closed-Loop Optogenetics:
A Technique to Study the Contribution of Hippocampal SWR Events to Learning.”
ENeuro, vol. 5, no. 4, e0087, Society of Neuroscience, 2018, doi:10.1523/ENEURO.0087-18.2018.'
short: D.K. Rangel Guerrero, J.G. Donnett, J.L. Csicsvari, K. Kovács, ENeuro 5 (2018).
date_created: 2019-02-03T22:59:16Z
date_published: 2018-07-27T00:00:00Z
date_updated: 2024-03-28T23:30:10Z
day: '27'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1523/ENEURO.0087-18.2018
ec_funded: 1
external_id:
isi:
- '000443994700007'
file:
- access_level: open_access
checksum: f4915d45fc7ad4648b7b7a13fdecca01
content_type: application/pdf
creator: dernst
date_created: 2019-02-05T12:48:36Z
date_updated: 2020-07-14T12:47:13Z
file_id: '5921'
file_name: 2018_ENeuro_Guerrero.pdf
file_size: 3746884
relation: main_file
file_date_updated: 2020-07-14T12:47:13Z
has_accepted_license: '1'
intvolume: ' 5'
isi: 1
issue: '4'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 257D4372-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I2072-B27
name: Interneuron plasticity during spatial learning
publication: eNeuro
publication_status: published
publisher: Society of Neuroscience
quality_controlled: '1'
related_material:
record:
- id: '6849'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation
closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR
events to learning'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 5
year: '2018'
...
---
_id: '1118'
abstract:
- lang: eng
text: Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation
during non-rapid eye movement sleep, immobility, and consummatory behavior. However,
whether temporally modulated synaptic excitation or inhibition underlies the ripples
is controversial. To address this question, we performed simultaneous recordings
of excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) and local
field potentials (LFPs) in the CA1 region of awake mice in vivo. During SWRs,
inhibition dominated over excitation, with a peak conductance ratio of 4.1 ± 0.5.
Furthermore, the amplitude of SWR-associated IPSCs was positively correlated with
SWR magnitude, whereas that of EPSCs was not. Finally, phase analysis indicated
that IPSCs were phase-locked to individual ripple cycles, whereas EPSCs were uniformly
distributed in phase space. Optogenetic inhibition indicated that PV+ interneurons
provided a major contribution to SWR-associated IPSCs. Thus, phasic inhibition,
but not excitation, shapes SWR oscillations in the hippocampal CA1 region in vivo.
acknowledged_ssus:
- _id: M-Shop
- _id: ScienComp
- _id: PreCl
article_processing_charge: No
author:
- first_name: Jian
full_name: Gan, Jian
id: 3614E438-F248-11E8-B48F-1D18A9856A87
last_name: Gan
- first_name: Shih-Ming
full_name: Weng, Shih-Ming
id: 2F9C5AC8-F248-11E8-B48F-1D18A9856A87
last_name: Weng
- first_name: Alejandro
full_name: Pernia-Andrade, Alejandro
id: 36963E98-F248-11E8-B48F-1D18A9856A87
last_name: Pernia-Andrade
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. Phase-locked inhibition,
but not excitation, underlies hippocampal ripple oscillations in awake mice in
vivo. Neuron. 2017;93(2):308-314. doi:10.1016/j.neuron.2016.12.018
apa: Gan, J., Weng, S.-M., Pernia-Andrade, A., Csicsvari, J. L., & Jonas, P.
M. (2017). Phase-locked inhibition, but not excitation, underlies hippocampal
ripple oscillations in awake mice in vivo. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2016.12.018
chicago: Gan, Jian, Shih-Ming Weng, Alejandro Pernia-Andrade, Jozsef L Csicsvari,
and Peter M Jonas. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal
Ripple Oscillations in Awake Mice in Vivo.” Neuron. Elsevier, 2017. https://doi.org/10.1016/j.neuron.2016.12.018.
ieee: J. Gan, S.-M. Weng, A. Pernia-Andrade, J. L. Csicsvari, and P. M. Jonas, “Phase-locked
inhibition, but not excitation, underlies hippocampal ripple oscillations in awake
mice in vivo,” Neuron, vol. 93, no. 2. Elsevier, pp. 308–314, 2017.
ista: Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. 2017. Phase-locked
inhibition, but not excitation, underlies hippocampal ripple oscillations in awake
mice in vivo. Neuron. 93(2), 308–314.
mla: Gan, Jian, et al. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal
Ripple Oscillations in Awake Mice in Vivo.” Neuron, vol. 93, no. 2, Elsevier,
2017, pp. 308–14, doi:10.1016/j.neuron.2016.12.018.
short: J. Gan, S.-M. Weng, A. Pernia-Andrade, J.L. Csicsvari, P.M. Jonas, Neuron
93 (2017) 308–314.
date_created: 2018-12-11T11:50:15Z
date_published: 2017-01-18T00:00:00Z
date_updated: 2023-09-20T11:31:48Z
day: '18'
ddc:
- '571'
department:
- _id: PeJo
- _id: JoCs
doi: 10.1016/j.neuron.2016.12.018
ec_funded: 1
external_id:
isi:
- '000396428200010'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:56Z
date_updated: 2018-12-12T10:08:56Z
file_id: '4719'
file_name: IST-2017-752-v1+1_1-s2.0-S0896627316309606-main.pdf
file_size: 2738950
relation: main_file
file_date_updated: 2018-12-12T10:08:56Z
has_accepted_license: '1'
intvolume: ' 93'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 308 - 314
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P24909-B24
name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '268548'
name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '6244'
pubrep_id: '752'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations
in awake mice in vivo
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 93
year: '2017'
...
---
_id: '1132'
abstract:
- lang: eng
text: The hippocampus is thought to initiate systems-wide mnemonic processes through
the reactivation of previously acquired spatial and episodic memory traces, which
can recruit the entorhinal cortex as a first stage of memory redistribution to
other brain areas. Hippocampal reactivation occurs during sharp wave-ripples,
in which synchronous network firing encodes sequences of places.We investigated
the coordination of this replay by recording assembly activity simultaneously
in the CA1 region of the hippocampus and superficial layers of the medial entorhinal
cortex. We found that entorhinal cell assemblies can replay trajectories independently
of the hippocampus and sharp wave-ripples. This suggests that the hippocampus
is not the sole initiator of spatial and episodic memory trace reactivation. Memory
systems involved in these processes may include nonhierarchical, parallel components.
article_processing_charge: No
author:
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Charlotte
full_name: Boccara, Charlotte
id: 3FC06552-F248-11E8-B48F-1D18A9856A87
last_name: Boccara
orcid: 0000-0001-7237-5109
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. Superficial
layers of the medial entorhinal cortex replay independently of the hippocampus.
Science. 2017;355(6321):184-188. doi:10.1126/science.aag2787
apa: O’Neill, J., Boccara, C. N., Stella, F., Schönenberger, P., & Csicsvari,
J. L. (2017). Superficial layers of the medial entorhinal cortex replay independently
of the hippocampus. Science. American Association for the Advancement of
Science. https://doi.org/10.1126/science.aag2787
chicago: O’Neill, Joseph, Charlotte N. Boccara, Federico Stella, Philipp Schönenberger,
and Jozsef L Csicsvari. “Superficial Layers of the Medial Entorhinal Cortex Replay
Independently of the Hippocampus.” Science. American Association for the
Advancement of Science, 2017. https://doi.org/10.1126/science.aag2787.
ieee: J. O’Neill, C. N. Boccara, F. Stella, P. Schönenberger, and J. L. Csicsvari,
“Superficial layers of the medial entorhinal cortex replay independently of the
hippocampus,” Science, vol. 355, no. 6321. American Association for the
Advancement of Science, pp. 184–188, 2017.
ista: O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. 2017. Superficial
layers of the medial entorhinal cortex replay independently of the hippocampus.
Science. 355(6321), 184–188.
mla: O’Neill, Joseph, et al. “Superficial Layers of the Medial Entorhinal Cortex
Replay Independently of the Hippocampus.” Science, vol. 355, no. 6321,
American Association for the Advancement of Science, 2017, pp. 184–88, doi:10.1126/science.aag2787.
short: J. O’Neill, C.N. Boccara, F. Stella, P. Schönenberger, J.L. Csicsvari, Science
355 (2017) 184–188.
date_created: 2018-12-11T11:50:19Z
date_published: 2017-01-13T00:00:00Z
date_updated: 2023-09-20T11:30:35Z
day: '13'
ddc:
- '571'
department:
- _id: JoCs
doi: 10.1126/science.aag2787
ec_funded: 1
external_id:
isi:
- '000391743700044'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:22Z
date_updated: 2018-12-12T10:10:22Z
file_id: '4809'
file_name: IST-2018-976-v1+1_2017Preprint_ONeill_Superficial_layers.pdf
file_size: 3761201
relation: main_file
file_date_updated: 2018-12-12T10:10:22Z
has_accepted_license: '1'
intvolume: ' 355'
isi: 1
issue: '6321'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 184 - 188
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Science
publication_identifier:
issn:
- '00368075'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '6226'
pubrep_id: '976'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superficial layers of the medial entorhinal cortex replay independently of
the hippocampus
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 355
year: '2017'
...
---
_id: '1279'
abstract:
- lang: eng
text: During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory
inputdriven neuronal firing patterns are replayed. Such replay is thought to be
important for plasticity- related processes and consolidation of memory traces.
It has previously been shown that the electrical stimulation-induced disruption
of SWR events interferes with learning in rodents in different experimental paradigms.
On the other hand, the cognitive map theory posits that the plastic changes of
the firing of hippocampal place cells constitute the electrophysiological counterpart
of the spatial learning, observable at the behavioral level. Therefore, we tested
whether intact SWR events occurring during the sleep/rest session after the first
exploration of a novel environment are needed for the stabilization of the CA1
code, which process requires plasticity. We found that the newly-formed representation
in the CA1 has the same level of stability with optogenetic SWR blockade as with
a control manipulation that delivered the same amount of light into the brain.
Therefore our results suggest that at least in the case of passive exploratory
behavior, SWR-related plasticity is dispensable for the stability of CA1 ensembles.
acknowledgement: 'The research leading to these results has received funding from
the People Programme (Marie Curie Actions) of the European Union''s Seventh Framework
Programme (FP7/2007-2013) under REA grant agreement n° [291734] via the IST FELLOWSHIP
awarded to Dr. Krisztián A. Kovács and the European Research Council starting grant
(acronym: HIPECMEM Project reference: 281511) awarded to Dr. Jozsef Csicsvari. We
thank Lauri Viljanto for technical help in building the ripple detector.'
article_number: e0164675
author:
- first_name: Krisztián
full_name: Kovács, Krisztián
id: 2AB5821E-F248-11E8-B48F-1D18A9856A87
last_name: Kovács
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: Dámaris K
full_name: Rangel Guerrero, Dámaris K
id: 4871BCE6-F248-11E8-B48F-1D18A9856A87
last_name: Rangel Guerrero
orcid: 0000-0002-8602-4374
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari
JL. Optogenetically blocking sharp wave ripple events in sleep does not interfere
with the formation of stable spatial representation in the CA1 area of the hippocampus.
PLoS One. 2016;11(10). doi:10.1371/journal.pone.0164675
apa: Kovács, K., O’Neill, J., Schönenberger, P., Penttonen, M., Rangel Guerrero,
D. K., & Csicsvari, J. L. (2016). Optogenetically blocking sharp wave ripple
events in sleep does not interfere with the formation of stable spatial representation
in the CA1 area of the hippocampus. PLoS One. Public Library of Science.
https://doi.org/10.1371/journal.pone.0164675
chicago: Kovács, Krisztián, Joseph O’Neill, Philipp Schönenberger, Markku Penttonen,
Dámaris K Rangel Guerrero, and Jozsef L Csicsvari. “Optogenetically Blocking Sharp
Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial
Representation in the CA1 Area of the Hippocampus.” PLoS One. Public Library
of Science, 2016. https://doi.org/10.1371/journal.pone.0164675.
ieee: K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D. K. Rangel Guerrero,
and J. L. Csicsvari, “Optogenetically blocking sharp wave ripple events in sleep
does not interfere with the formation of stable spatial representation in the
CA1 area of the hippocampus,” PLoS One, vol. 11, no. 10. Public Library
of Science, 2016.
ista: Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari
JL. 2016. Optogenetically blocking sharp wave ripple events in sleep does not
interfere with the formation of stable spatial representation in the CA1 area
of the hippocampus. PLoS One. 11(10), e0164675.
mla: Kovács, Krisztián, et al. “Optogenetically Blocking Sharp Wave Ripple Events
in Sleep Does Not Interfere with the Formation of Stable Spatial Representation
in the CA1 Area of the Hippocampus.” PLoS One, vol. 11, no. 10, e0164675,
Public Library of Science, 2016, doi:10.1371/journal.pone.0164675.
short: K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D.K. Rangel Guerrero,
J.L. Csicsvari, PLoS One 11 (2016).
date_created: 2018-12-11T11:51:06Z
date_published: 2016-10-19T00:00:00Z
date_updated: 2021-01-12T06:49:35Z
day: '19'
ddc:
- '570'
- '571'
department:
- _id: JoCs
doi: 10.1371/journal.pone.0164675
ec_funded: 1
file:
- access_level: open_access
checksum: 395895ecb2216e9c39135abaa56b28b3
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:26Z
date_updated: 2020-07-14T12:44:42Z
file_id: '5009'
file_name: IST-2016-690-v1+1_journal.pone.0164675.PDF
file_size: 4353592
relation: main_file
file_date_updated: 2020-07-14T12:44:42Z
has_accepted_license: '1'
intvolume: ' 11'
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '6037'
pubrep_id: '690'
quality_controlled: '1'
scopus_import: 1
status: public
title: Optogenetically blocking sharp wave ripple events in sleep does not interfere
with the formation of stable spatial representation in the CA1 area of the hippocampus
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2016'
...
---
_id: '1334'
abstract:
- lang: eng
text: Hippocampal neurons encode a cognitive map of space. These maps are thought
to be updated during learning and in response to changes in the environment through
activity-dependent synaptic plasticity. Here we examine how changes in activity
influence spatial coding in rats using halorhodopsin-mediated, spatially selective
optogenetic silencing. Halorhoposin stimulation leads to light-induced suppression
in many place cells and interneurons; some place cells increase their firing through
disinhibition, whereas some show no effect. We find that place fields of the unaffected
subpopulation remain stable. On the other hand, place fields of suppressed place
cells were unstable, showing remapping across sessions before and after optogenetic
inhibition. Disinhibited place cells had stable maps but sustained an elevated
firing rate. These findings suggest that place representation in the hippocampus
is constantly governed by activity-dependent processes, and that disinhibition
may provide a mechanism for rate remapping.
article_number: '11824'
author:
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Schönenberger P, O’Neill J, Csicsvari JL. Activity dependent plasticity of
hippocampal place maps. Nature Communications. 2016;7. doi:10.1038/ncomms11824
apa: Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2016). Activity dependent
plasticity of hippocampal place maps. Nature Communications. Nature Publishing
Group. https://doi.org/10.1038/ncomms11824
chicago: Schönenberger, Philipp, Joseph O’Neill, and Jozsef L Csicsvari. “Activity
Dependent Plasticity of Hippocampal Place Maps.” Nature Communications.
Nature Publishing Group, 2016. https://doi.org/10.1038/ncomms11824.
ieee: P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Activity dependent plasticity
of hippocampal place maps,” Nature Communications, vol. 7. Nature Publishing
Group, 2016.
ista: Schönenberger P, O’Neill J, Csicsvari JL. 2016. Activity dependent plasticity
of hippocampal place maps. Nature Communications. 7, 11824.
mla: Schönenberger, Philipp, et al. “Activity Dependent Plasticity of Hippocampal
Place Maps.” Nature Communications, vol. 7, 11824, Nature Publishing Group,
2016, doi:10.1038/ncomms11824.
short: P. Schönenberger, J. O’Neill, J.L. Csicsvari, Nature Communications 7 (2016).
date_created: 2018-12-11T11:51:26Z
date_published: 2016-06-10T00:00:00Z
date_updated: 2021-01-12T06:49:57Z
day: '10'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1038/ncomms11824
ec_funded: 1
file:
- access_level: open_access
checksum: e43307754abe65b840a21939fe163618
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:10Z
date_updated: 2020-07-14T12:44:44Z
file_id: '5196'
file_name: IST-2016-660-v1+1_ncomms11824.pdf
file_size: 1793846
relation: main_file
file_date_updated: 2020-07-14T12:44:44Z
has_accepted_license: '1'
intvolume: ' 7'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 257D4372-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I2072-B27
name: Interneuron plasticity during spatial learning
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5934'
pubrep_id: '660'
quality_controlled: '1'
scopus_import: 1
status: public
title: Activity dependent plasticity of hippocampal place maps
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2016'
...
---
_id: '2003'
abstract:
- lang: eng
text: Learning can be facilitated by previous knowledge when it is organized into
relational representations forming schemas. In this issue of Neuron, McKenzie
et al. (2014) demonstrate that the hippocampus rapidly forms interrelated, hierarchical
memory representations to support schema-based learning.
author:
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Csicsvari JL. Learning by example in the hippocampus. Neuron.
2014;83(1):8-10. doi:10.1016/j.neuron.2014.06.013
apa: O’Neill, J., & Csicsvari, J. L. (2014). Learning by example in the hippocampus.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2014.06.013
chicago: O’Neill, Joseph, and Jozsef L Csicsvari. “Learning by Example in the Hippocampus.”
Neuron. Elsevier, 2014. https://doi.org/10.1016/j.neuron.2014.06.013.
ieee: J. O’Neill and J. L. Csicsvari, “Learning by example in the hippocampus,”
Neuron, vol. 83, no. 1. Elsevier, pp. 8–10, 2014.
ista: O’Neill J, Csicsvari JL. 2014. Learning by example in the hippocampus. Neuron.
83(1), 8–10.
mla: O’Neill, Joseph, and Jozsef L. Csicsvari. “Learning by Example in the Hippocampus.”
Neuron, vol. 83, no. 1, Elsevier, 2014, pp. 8–10, doi:10.1016/j.neuron.2014.06.013.
short: J. O’Neill, J.L. Csicsvari, Neuron 83 (2014) 8–10.
date_created: 2018-12-11T11:55:09Z
date_published: 2014-07-02T00:00:00Z
date_updated: 2021-01-12T06:54:39Z
day: '02'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2014.06.013
intvolume: ' 83'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 8 - 10
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '5073'
quality_controlled: '1'
scopus_import: 1
status: public
title: Learning by example in the hippocampus
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 83
year: '2014'
...
---
_id: '2005'
abstract:
- lang: eng
text: By eliciting a natural exploratory behavior in rats, head scanning, a study
reveals that hippocampal place cells form new, stable firing fields in those locations
where the behavior has just occurred.
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, Csicsvari JL. Turning heads to remember places. Nature Neuroscience.
2014;17(5):643-644. doi:10.1038/nn.3700
apa: Dupret, D., & Csicsvari, J. L. (2014). Turning heads to remember places.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3700
chicago: Dupret, David, and Jozsef L Csicsvari. “Turning Heads to Remember Places.”
Nature Neuroscience. Nature Publishing Group, 2014. https://doi.org/10.1038/nn.3700.
ieee: D. Dupret and J. L. Csicsvari, “Turning heads to remember places,” Nature
Neuroscience, vol. 17, no. 5. Nature Publishing Group, pp. 643–644, 2014.
ista: Dupret D, Csicsvari JL. 2014. Turning heads to remember places. Nature Neuroscience.
17(5), 643–644.
mla: Dupret, David, and Jozsef L. Csicsvari. “Turning Heads to Remember Places.”
Nature Neuroscience, vol. 17, no. 5, Nature Publishing Group, 2014, pp.
643–44, doi:10.1038/nn.3700.
short: D. Dupret, J.L. Csicsvari, Nature Neuroscience 17 (2014) 643–644.
date_created: 2018-12-11T11:55:09Z
date_published: 2014-04-25T00:00:00Z
date_updated: 2021-01-12T06:54:40Z
day: '25'
department:
- _id: JoCs
doi: 10.1038/nn.3700
intvolume: ' 17'
issue: '5'
language:
- iso: eng
month: '04'
oa_version: None
page: 643 - 644
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '5071'
quality_controlled: '1'
scopus_import: 1
status: public
title: Turning heads to remember places
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2014'
...
---
_id: '2251'
abstract:
- lang: eng
text: 'Sharp wave/ripple (SWR, 150–250 Hz) hippocampal events have long been postulated
to be involved in memory consolidation. However, more recent work has investigated
SWRs that occur during active waking behaviour: findings that suggest that SWRs
may also play a role in cell assembly strengthening or spatial working memory.
Do such theories of SWR function apply to animal learning? This review discusses
how general theories linking SWRs to memory-related function may explain circuit
mechanisms related to rodent spatial learning and to the associated stabilization
of new cognitive maps.'
acknowledgement: CC BY 3.0
article_number: '20120528'
article_processing_charge: No
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: David
full_name: Dupret, David
last_name: Dupret
citation:
ama: Csicsvari JL, Dupret D. Sharp wave/ripple network oscillations and learning-associated
hippocampal maps. Philosophical Transactions of the Royal Society of London
Series B, Biological Sciences. 2014;369(1635). doi:10.1098/rstb.2012.0528
apa: Csicsvari, J. L., & Dupret, D. (2014). Sharp wave/ripple network oscillations
and learning-associated hippocampal maps. Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences. Royal Society, The.
https://doi.org/10.1098/rstb.2012.0528
chicago: Csicsvari, Jozsef L, and David Dupret. “Sharp Wave/Ripple Network Oscillations
and Learning-Associated Hippocampal Maps.” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences. Royal Society, The,
2014. https://doi.org/10.1098/rstb.2012.0528.
ieee: J. L. Csicsvari and D. Dupret, “Sharp wave/ripple network oscillations and
learning-associated hippocampal maps,” Philosophical Transactions of the Royal
Society of London. Series B, Biological Sciences, vol. 369, no. 1635. Royal
Society, The, 2014.
ista: Csicsvari JL, Dupret D. 2014. Sharp wave/ripple network oscillations and learning-associated
hippocampal maps. Philosophical Transactions of the Royal Society of London. Series
B, Biological Sciences. 369(1635), 20120528.
mla: Csicsvari, Jozsef L., and David Dupret. “Sharp Wave/Ripple Network Oscillations
and Learning-Associated Hippocampal Maps.” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences, vol. 369, no. 1635,
20120528, Royal Society, The, 2014, doi:10.1098/rstb.2012.0528.
short: J.L. Csicsvari, D. Dupret, Philosophical Transactions of the Royal Society
of London. Series B, Biological Sciences 369 (2014).
date_created: 2018-12-11T11:56:34Z
date_published: 2014-02-05T00:00:00Z
date_updated: 2021-01-12T06:56:18Z
day: '05'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1098/rstb.2012.0528
external_id:
pmid:
- '24366138'
file:
- access_level: open_access
checksum: 51beb33de71c9c19e0c205a20d206f9a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:24Z
date_updated: 2020-07-14T12:45:34Z
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file_name: IST-2016-527-v1+1_20120528.full.pdf
file_size: 771896
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issue: '1635'
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month: '02'
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oa_version: Published Version
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
Biological Sciences
publication_identifier:
issn:
- '09628436'
publication_status: published
publisher: Royal Society, The
publist_id: '4697'
pubrep_id: '527'
quality_controlled: '1'
scopus_import: 1
status: public
title: Sharp wave/ripple network oscillations and learning-associated hippocampal
maps
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 369
year: '2014'
...
---
_id: '2860'
abstract:
- lang: eng
text: 'In the hippocampus, cell assemblies forming mnemonic representations of space
are thought to arise as a result of changes in functional connections of pyramidal
cells. We have found that CA1 interneuron circuits are also reconfigured during
goal-oriented spatial learning through modification of inputs from pyramidal cells.
As learning progressed, new pyramidal assemblies expressed in theta cycles alternated
with previously established ones, and eventually overtook them. The firing patterns
of interneurons developed a relationship to new, learning-related assemblies:
some interneurons associated their activity with new pyramidal assemblies while
some others dissociated from them. These firing associations were explained by
changes in the weight of monosynaptic inputs received by interneurons from new
pyramidal assemblies, as these predicted the associational changes. Spatial learning
thus engages circuit modifications in the hippocampus that incorporate a redistribution
of inhibitory activity that might assist in the segregation of competing pyramidal
cell assembly patterns in space and time.'
acknowledgement: D.D. and J.C. were supported by a MRC Intramural Programme Grant
U138197111
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, O’Neill J, Csicsvari JL. Dynamic reconfiguration of hippocampal interneuron
circuits during spatial learning. Neuron. 2013;78(1):166-180. doi:10.1016/j.neuron.2013.01.033
apa: Dupret, D., O’Neill, J., & Csicsvari, J. L. (2013). Dynamic reconfiguration
of hippocampal interneuron circuits during spatial learning. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2013.01.033
chicago: Dupret, David, Joseph O’Neill, and Jozsef L Csicsvari. “Dynamic Reconfiguration
of Hippocampal Interneuron Circuits during Spatial Learning.” Neuron. Elsevier,
2013. https://doi.org/10.1016/j.neuron.2013.01.033.
ieee: D. Dupret, J. O’Neill, and J. L. Csicsvari, “Dynamic reconfiguration of hippocampal
interneuron circuits during spatial learning,” Neuron, vol. 78, no. 1.
Elsevier, pp. 166–180, 2013.
ista: Dupret D, O’Neill J, Csicsvari JL. 2013. Dynamic reconfiguration of hippocampal
interneuron circuits during spatial learning. Neuron. 78(1), 166–180.
mla: Dupret, David, et al. “Dynamic Reconfiguration of Hippocampal Interneuron Circuits
during Spatial Learning.” Neuron, vol. 78, no. 1, Elsevier, 2013, pp. 166–80,
doi:10.1016/j.neuron.2013.01.033.
short: D. Dupret, J. O’Neill, J.L. Csicsvari, Neuron 78 (2013) 166–180.
date_created: 2018-12-11T11:59:59Z
date_published: 2013-03-21T00:00:00Z
date_updated: 2021-01-12T07:00:19Z
day: '21'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2013.01.033
ec_funded: 1
file:
- access_level: open_access
checksum: 0e18cb8561153ddb50bb5af16e7c9e97
content_type: application/pdf
creator: dernst
date_created: 2019-01-23T08:08:07Z
date_updated: 2020-07-14T12:45:52Z
file_id: '5877'
file_name: 2013_Neuron_Dupret.pdf
file_size: 2637837
relation: main_file
file_date_updated: 2020-07-14T12:45:52Z
has_accepted_license: '1'
intvolume: ' 78'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 166 - 180
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '3929'
quality_controlled: '1'
scopus_import: 1
status: public
title: Dynamic reconfiguration of hippocampal interneuron circuits during spatial
learning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 78
year: '2013'
...
---
_id: '2949'
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, Csicsvari JL. The medial entorhinal cortex keeps Up. Nature Neuroscience.
2012;15(11):1471-1472. doi:10.1038/nn.3245
apa: Dupret, D., & Csicsvari, J. L. (2012). The medial entorhinal cortex keeps
Up. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3245
chicago: Dupret, David, and Jozsef L Csicsvari. “The Medial Entorhinal Cortex Keeps
Up.” Nature Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nn.3245.
ieee: D. Dupret and J. L. Csicsvari, “The medial entorhinal cortex keeps Up,” Nature
Neuroscience, vol. 15, no. 11. Nature Publishing Group, pp. 1471–1472, 2012.
ista: Dupret D, Csicsvari JL. 2012. The medial entorhinal cortex keeps Up. Nature
Neuroscience. 15(11), 1471–1472.
mla: Dupret, David, and Jozsef L. Csicsvari. “The Medial Entorhinal Cortex Keeps
Up.” Nature Neuroscience, vol. 15, no. 11, Nature Publishing Group, 2012,
pp. 1471–72, doi:10.1038/nn.3245.
short: D. Dupret, J.L. Csicsvari, Nature Neuroscience 15 (2012) 1471–1472.
date_created: 2018-12-11T12:00:30Z
date_published: 2012-11-01T00:00:00Z
date_updated: 2021-01-12T07:39:59Z
day: '01'
department:
- _id: JoCs
doi: 10.1038/nn.3245
intvolume: ' 15'
issue: '11'
language:
- iso: eng
main_file_link:
- url: http://www.mrcbndu.ox.ac.uk/publications/medial-entorhinal-cortex-keeps
month: '11'
oa_version: None
page: 1471 - 1472
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '3782'
quality_controlled: '1'
scopus_import: 1
status: public
title: The medial entorhinal cortex keeps Up
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2012'
...
---
_id: '2958'
abstract:
- lang: eng
text: 'The activity of hippocampal pyramidal cells reflects both the current position
of the animal and information related to its current behavior. Here we investigated
whether single hippocampal neurons can encode several independent features defining
trials during a memory task. We also tested whether task-related information is
represented by partial remapping of the place cell population or, instead, via
firing rate modulation of spatially stable place cells. To address these two questions,
the activity of hippocampal neurons was recorded in rats performing a conditional
discrimination task on a modified T-maze in which the identity of a food reward
guided behavior. When the rat was on the central arm of the maze, the firing rate
of pyramidal cells changed depending on two independent factors: (1) the identity
of the food reward given to the animal and (2) the previous location of the animal
on the maze. Importantly, some pyramidal cells encoded information relative to
both factors. This trial-type specific and retrospective coding did not interfere
with the spatial representation of the maze: hippocampal cells had stable place
fields and their theta-phase precession profiles were unaltered during the task,
indicating that trial-related information was encoded via rate remapping. During
error trials, encoding of both trial-related information and spatial location
was impaired. Finally, we found that pyramidal cells also encode trial-related
information via rate remapping during the continuous version of the rewarded alternation
task without delays. These results suggest that hippocampal neurons can encode
several task-related cognitive aspects via rate remapping.'
acknowledgement: J.C. was supported by a MRC Intramural Programme Grant (U138197111)
and a European Research Council Starter Grant (281511). K.A. held a Wellcome Trust
PhD studentship and a Humboldt Research Fellowship for Postdoctoral Researchers.
D.M.B. was supported by Wellcome Trust Senior Fellowships (074385 and 087736).
author:
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: J Nick
full_name: Rawlins, J Nick
last_name: Rawlins
- first_name: David
full_name: Bannerman, David
last_name: Bannerman
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. Hippocampal place cells can
encode multiple trial-dependent features through rate remapping. Journal of
Neuroscience. 2012;32(42):14752-14766. doi:10.1523/JNEUROSCI.6175-11.2012
apa: Allen, K., Rawlins, J. N., Bannerman, D., & Csicsvari, J. L. (2012). Hippocampal
place cells can encode multiple trial-dependent features through rate remapping.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.6175-11.2012
chicago: Allen, Kevin, J Nick Rawlins, David Bannerman, and Jozsef L Csicsvari.
“Hippocampal Place Cells Can Encode Multiple Trial-Dependent Features through
Rate Remapping.” Journal of Neuroscience. Society for Neuroscience, 2012.
https://doi.org/10.1523/JNEUROSCI.6175-11.2012.
ieee: K. Allen, J. N. Rawlins, D. Bannerman, and J. L. Csicsvari, “Hippocampal place
cells can encode multiple trial-dependent features through rate remapping,” Journal
of Neuroscience, vol. 32, no. 42. Society for Neuroscience, pp. 14752–14766,
2012.
ista: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. 2012. Hippocampal place cells
can encode multiple trial-dependent features through rate remapping. Journal of
Neuroscience. 32(42), 14752–14766.
mla: Allen, Kevin, et al. “Hippocampal Place Cells Can Encode Multiple Trial-Dependent
Features through Rate Remapping.” Journal of Neuroscience, vol. 32, no.
42, Society for Neuroscience, 2012, pp. 14752–66, doi:10.1523/JNEUROSCI.6175-11.2012.
short: K. Allen, J.N. Rawlins, D. Bannerman, J.L. Csicsvari, Journal of Neuroscience
32 (2012) 14752–14766.
date_created: 2018-12-11T12:00:33Z
date_published: 2012-10-17T00:00:00Z
date_updated: 2021-01-12T07:40:03Z
day: '17'
department:
- _id: JoCs
doi: 10.1523/JNEUROSCI.6175-11.2012
ec_funded: 1
external_id:
pmid:
- '23077060'
intvolume: ' 32'
issue: '42'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531717/
month: '10'
oa: 1
oa_version: Submitted Version
page: 14752 - 14766
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '3768'
quality_controlled: '1'
scopus_import: 1
status: public
title: Hippocampal place cells can encode multiple trial-dependent features through
rate remapping
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2012'
...
---
_id: '3138'
abstract:
- lang: eng
text: Hippocampal sharp waves (SPWs) and associated fast ("ripple") oscillations
(SPW-Rs) in the CA1 region are among the most synchronous physiological patterns
in the mammalian brain. Using two-dimensional arrays of electrodes for recording
local field potentials and unit discharges in freely moving rats, we studied the
emergence of ripple oscillations (140-220 Hz) and compared their origin and cellular-synaptic
mechanisms with fast gamma oscillations (90-140 Hz). We show that (1) hippocampal
SPW-Rs and fast gamma oscillations are quantitatively distinct patterns but involve
the same networks and share similar mechanisms; (2) both the frequency and magnitude
of fast oscillations are positively correlated with the magnitude of SPWs; (3)
during both ripples and fast gamma oscillations the frequency of network oscillation
is higher in CA1 than in CA3; and (4) the emergence of CA3 population bursts,
a prerequisite for SPW-Rs, is biased by activity patterns in the dentate gyrus
and entorhinal cortex, with the highest probability of ripples associated with
an "optimum" level of dentate gamma power. We hypothesize that each
hippocampal subnetwork possesses distinct resonant properties, tuned by the magnitude
of the excitatory drive.
author:
- first_name: David
full_name: Sullivan, David W
last_name: Sullivan
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Kenji
full_name: Mizuseki, Kenji
last_name: Mizuseki
- first_name: Sean
full_name: Montgomery, Sean M
last_name: Montgomery
- first_name: Kamran
full_name: Diba, Kamran
last_name: Diba
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Sullivan D, Csicsvari JL, Mizuseki K, Montgomery S, Diba K, Buzsáki G. Relationships
between hippocampal sharp waves ripples and fast gamma oscillation Influence of
dentate and entorhinal cortical activity. Journal of Neuroscience. 2011;31(23):8605-8616.
doi:10.1523/JNEUROSCI.0294-11.2011
apa: Sullivan, D., Csicsvari, J. L., Mizuseki, K., Montgomery, S., Diba, K., &
Buzsáki, G. (2011). Relationships between hippocampal sharp waves ripples and
fast gamma oscillation Influence of dentate and entorhinal cortical activity.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0294-11.2011
chicago: Sullivan, David, Jozsef L Csicsvari, Kenji Mizuseki, Sean Montgomery, Kamran
Diba, and György Buzsáki. “Relationships between Hippocampal Sharp Waves Ripples
and Fast Gamma Oscillation Influence of Dentate and Entorhinal Cortical Activity.”
Journal of Neuroscience. Society for Neuroscience, 2011. https://doi.org/10.1523/JNEUROSCI.0294-11.2011.
ieee: D. Sullivan, J. L. Csicsvari, K. Mizuseki, S. Montgomery, K. Diba, and G.
Buzsáki, “Relationships between hippocampal sharp waves ripples and fast gamma
oscillation Influence of dentate and entorhinal cortical activity,” Journal
of Neuroscience, vol. 31, no. 23. Society for Neuroscience, pp. 8605–8616,
2011.
ista: Sullivan D, Csicsvari JL, Mizuseki K, Montgomery S, Diba K, Buzsáki G. 2011.
Relationships between hippocampal sharp waves ripples and fast gamma oscillation
Influence of dentate and entorhinal cortical activity. Journal of Neuroscience.
31(23), 8605–8616.
mla: Sullivan, David, et al. “Relationships between Hippocampal Sharp Waves Ripples
and Fast Gamma Oscillation Influence of Dentate and Entorhinal Cortical Activity.”
Journal of Neuroscience, vol. 31, no. 23, Society for Neuroscience, 2011,
pp. 8605–16, doi:10.1523/JNEUROSCI.0294-11.2011.
short: D. Sullivan, J.L. Csicsvari, K. Mizuseki, S. Montgomery, K. Diba, G. Buzsáki,
Journal of Neuroscience 31 (2011) 8605–8616.
date_created: 2018-12-11T12:01:36Z
date_published: 2011-06-08T00:00:00Z
date_updated: 2021-01-12T07:41:19Z
day: '08'
doi: 10.1523/JNEUROSCI.0294-11.2011
extern: 1
intvolume: ' 31'
issue: '23'
month: '06'
page: 8605 - 8616
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '3559'
quality_controlled: 0
status: public
title: Relationships between hippocampal sharp waves ripples and fast gamma oscillation
Influence of dentate and entorhinal cortical activity
type: journal_article
volume: 31
year: '2011'
...
---
_id: '3441'
abstract:
- lang: eng
text: The hippocampus is an important brain circuit for spatial memory and the spatially
selective spiking of hippocampal neuronal assemblies is thought to provide a mnemonic
representation of space. We found that remembering newly learnt goal locations
required NMDA receptorĝ€"dependent stabilization and enhanced reactivation
of goal-related hippocampal assemblies. During spatial learning, place-related
firing patterns in the CA1, but not CA3, region of the rat hippocampus were reorganized
to represent new goal locations. Such reorganization did not occur when goals
were marked by visual cues. The stabilization and successful retrieval of these
newly acquired CA1 representations of behaviorally relevant places was NMDAR dependent
and necessary for subsequent memory retention performance. Goal-related assembly
patterns associated with sharp wave/ripple network oscillations, during both learning
and subsequent rest periods, predicted memory performance. Together, these results
suggest that the reorganization and reactivation of assembly firing patterns in
the hippocampus represent the formation and expression of new spatial memory traces.
© 2010 Nature America, Inc. All rights reserved.
acknowledgement: |
Discussed in the News and Views section of the journal by Jeffery and Cacucci
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Barty
full_name: Pleydell-Bouverie, Barty
last_name: Pleydell Bouverie
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, O’Neill J, Pleydell Bouverie B, Csicsvari JL. The reorganization
and reactivation of hippocampal maps predict spatial memory performance. Nature
Neuroscience. 2010;13(8):995-1002. doi:10.1038/nn.2599
apa: Dupret, D., O’Neill, J., Pleydell Bouverie, B., & Csicsvari, J. L. (2010).
The reorganization and reactivation of hippocampal maps predict spatial memory
performance. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.2599
chicago: Dupret, David, Joseph O’Neill, Barty Pleydell Bouverie, and Jozsef L Csicsvari.
“The Reorganization and Reactivation of Hippocampal Maps Predict Spatial Memory
Performance.” Nature Neuroscience. Nature Publishing Group, 2010. https://doi.org/10.1038/nn.2599.
ieee: D. Dupret, J. O’Neill, B. Pleydell Bouverie, and J. L. Csicsvari, “The reorganization
and reactivation of hippocampal maps predict spatial memory performance,” Nature
Neuroscience, vol. 13, no. 8. Nature Publishing Group, pp. 995–1002, 2010.
ista: Dupret D, O’Neill J, Pleydell Bouverie B, Csicsvari JL. 2010. The reorganization
and reactivation of hippocampal maps predict spatial memory performance. Nature
Neuroscience. 13(8), 995–1002.
mla: Dupret, David, et al. “The Reorganization and Reactivation of Hippocampal Maps
Predict Spatial Memory Performance.” Nature Neuroscience, vol. 13, no.
8, Nature Publishing Group, 2010, pp. 995–1002, doi:10.1038/nn.2599.
short: D. Dupret, J. O’Neill, B. Pleydell Bouverie, J.L. Csicsvari, Nature Neuroscience
13 (2010) 995–1002.
date_created: 2018-12-11T12:03:21Z
date_published: 2010-08-01T00:00:00Z
date_updated: 2021-01-12T07:43:29Z
day: '01'
doi: 10.1038/nn.2599
extern: 1
intvolume: ' 13'
issue: '8'
month: '08'
page: 995 - 1002
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '2946'
quality_controlled: 0
status: public
title: The reorganization and reactivation of hippocampal maps predict spatial memory
performance
type: journal_article
volume: 13
year: '2010'
...
---
_id: '3442'
abstract:
- lang: eng
text: Episodic and spatial memories each involve the encoding of complex associations
in hippocampal neuronal circuits. Such memory traces could be stabilised from
short- to long-term forms by consolidation processes involving the 'reactivation'
of the original network firing patterns during sleep and rest. Waking experience
can be replayed in many different brain areas, but an important role for the hippocampus
lies in the organisation of the 'reactivation' process. Emerging evidence suggests
that sharp wave/ripple (SWR) events in the hippocampus could coordinate the reactivation
of memory traces and direct their reinstatement in cortical circuits. Although
the mechanisms remain uncertain, there is a growing consensus that such SWR-directed
reactivation of brain-wide memory traces could underlie memory consolidation.
© 2010 Elsevier Ltd.
author:
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Barty
full_name: Pleydell-Bouverie, Barty
last_name: Pleydell Bouverie
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: 'O’Neill J, Pleydell Bouverie B, Dupret D, Csicsvari JL. Play it again: reactivation
of waking experience and memory. Trends in Neurosciences. 2010;33(5):220-229.
doi:10.1016/j.tins.2010.01.006'
apa: 'O’Neill, J., Pleydell Bouverie, B., Dupret, D., & Csicsvari, J. L. (2010).
Play it again: reactivation of waking experience and memory. Trends in Neurosciences.
Elsevier. https://doi.org/10.1016/j.tins.2010.01.006'
chicago: 'O’Neill, Joseph, Barty Pleydell Bouverie, David Dupret, and Jozsef L Csicsvari.
“Play It Again: Reactivation of Waking Experience and Memory.” Trends in Neurosciences.
Elsevier, 2010. https://doi.org/10.1016/j.tins.2010.01.006.'
ieee: 'J. O’Neill, B. Pleydell Bouverie, D. Dupret, and J. L. Csicsvari, “Play it
again: reactivation of waking experience and memory,” Trends in Neurosciences,
vol. 33, no. 5. Elsevier, pp. 220–229, 2010.'
ista: 'O’Neill J, Pleydell Bouverie B, Dupret D, Csicsvari JL. 2010. Play it again:
reactivation of waking experience and memory. Trends in Neurosciences. 33(5),
220–229.'
mla: 'O’Neill, Joseph, et al. “Play It Again: Reactivation of Waking Experience
and Memory.” Trends in Neurosciences, vol. 33, no. 5, Elsevier, 2010, pp.
220–29, doi:10.1016/j.tins.2010.01.006.'
short: J. O’Neill, B. Pleydell Bouverie, D. Dupret, J.L. Csicsvari, Trends in Neurosciences
33 (2010) 220–229.
date_created: 2018-12-11T12:03:21Z
date_published: 2010-05-01T00:00:00Z
date_updated: 2021-01-12T07:43:29Z
day: '01'
doi: 10.1016/j.tins.2010.01.006
extern: 1
intvolume: ' 33'
issue: '5'
month: '05'
page: 220 - 229
publication: Trends in Neurosciences
publication_status: published
publisher: Elsevier
publist_id: '2945'
quality_controlled: 0
status: public
title: 'Play it again: reactivation of waking experience and memory'
type: journal_article
volume: 33
year: '2010'
...
---
_id: '3538'
abstract:
- lang: eng
text: How seizures start is a major question in epilepsy research. Preictal EEG
changes occur in both human patients and animal models, but their underlying mechanisms
and relationship with seizure initiation remain unknown. Here we demonstrate the
existence, in the hippocampal CA1 region, of a preictal state characterized by
the progressive and global increase in neuronal activity associated with a widespread
buildup of low-amplitude high-frequency activity (HFA) (> 100 Hz) and reduction
in system complexity. HFA is generated by the firing of neurons, mainly pyramidal
cells, at much lower frequencies. Individual cycles of HFA are generated by the
near-synchronous (within similar to 5 ms) firing of small numbers of pyramidal
cells. The presence of HFA in the low-calcium model implicates nonsynaptic synchronization;
the presence of very similar HFA in the high-potassium model shows that it does
not depend on an absence of synaptic transmission. Immediately before seizure
onset, CA1 is in a state of high sensitivity in which weak depolarizing or synchronizing
perturbations can trigger seizures. Transition to seizure is characterized by
a rapid expansion and fusion of the neuronal populations responsible for HFA,
associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous
cluster generating the high-amplitude low-frequency activity of the seizure.
author:
- first_name: Premysl
full_name: Jiruska, Premysl
last_name: Jiruska
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Andrew
full_name: Powell, Andrew
last_name: Powell
- first_name: John
full_name: Fox, John
last_name: Fox
- first_name: Wei
full_name: Chang, Wei
last_name: Chang
- first_name: Martin
full_name: Vreugdenhil, Martin
last_name: Vreugdenhil
- first_name: Xiaoli
full_name: Li, Xiaoli
last_name: Li
- first_name: Milan
full_name: Palus, Milan
last_name: Palus
- first_name: Alejandro
full_name: Bujan, Alejandro
last_name: Bujan
- first_name: Richard
full_name: Dearden, Richard
last_name: Dearden
- first_name: John
full_name: Jefferys, John
last_name: Jefferys
citation:
ama: Jiruska P, Csicsvari JL, Powell A, et al. High-frequency network activity,
global increase in neuronal activity, and synchrony expansion precede epileptic
seizures in vitro. Journal of Neuroscience. 2010;30(16):5690-5701. doi:10.1523/JNEUROSCI.0535-10.2010
apa: Jiruska, P., Csicsvari, J. L., Powell, A., Fox, J., Chang, W., Vreugdenhil,
M., … Jefferys, J. (2010). High-frequency network activity, global increase in
neuronal activity, and synchrony expansion precede epileptic seizures in vitro.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0535-10.2010
chicago: Jiruska, Premysl, Jozsef L Csicsvari, Andrew Powell, John Fox, Wei Chang,
Martin Vreugdenhil, Xiaoli Li, et al. “High-Frequency Network Activity, Global
Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures
in Vitro.” Journal of Neuroscience. Society for Neuroscience, 2010. https://doi.org/10.1523/JNEUROSCI.0535-10.2010.
ieee: P. Jiruska et al., “High-frequency network activity, global increase
in neuronal activity, and synchrony expansion precede epileptic seizures in vitro,”
Journal of Neuroscience, vol. 30, no. 16. Society for Neuroscience, pp.
5690–5701, 2010.
ista: Jiruska P, Csicsvari JL, Powell A, Fox J, Chang W, Vreugdenhil M, Li X, Palus
M, Bujan A, Dearden R, Jefferys J. 2010. High-frequency network activity, global
increase in neuronal activity, and synchrony expansion precede epileptic seizures
in vitro. Journal of Neuroscience. 30(16), 5690–5701.
mla: Jiruska, Premysl, et al. “High-Frequency Network Activity, Global Increase
in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro.”
Journal of Neuroscience, vol. 30, no. 16, Society for Neuroscience, 2010,
pp. 5690–701, doi:10.1523/JNEUROSCI.0535-10.2010.
short: P. Jiruska, J.L. Csicsvari, A. Powell, J. Fox, W. Chang, M. Vreugdenhil,
X. Li, M. Palus, A. Bujan, R. Dearden, J. Jefferys, Journal of Neuroscience 30
(2010) 5690–5701.
date_created: 2018-12-11T12:03:51Z
date_published: 2010-04-21T00:00:00Z
date_updated: 2021-01-12T07:44:10Z
day: '21'
doi: 10.1523/JNEUROSCI.0535-10.2010
extern: '1'
intvolume: ' 30'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.jneurosci.org/content/30/16/5690
month: '04'
oa: 1
oa_version: None
page: 5690 - 5701
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2848'
quality_controlled: '1'
status: public
title: High-frequency network activity, global increase in neuronal activity, and
synchrony expansion precede epileptic seizures in vitro
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2010'
...
---
_id: '3403'
abstract:
- lang: eng
text: Rate remapping is a conjunctive code that potentially enables hippocampal
place cells to jointly represent spatial and nonspatial information. In this issue
of Neuron, Rennó-Costa et al. introduce a theoretical model wherein the convergence
of the medial and lateral entorhinal excitatory inputs, combined with local inhibition,
explains hippocampal rate remapping. © 2010 Elsevier Inc.
author:
- first_name: Barty
full_name: Pleydell-Bouverie, Barty
last_name: Pleydell Bouverie
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: 'Pleydell Bouverie B, Csicsvari JL. Rate remapping: When the code goes beyond
space (preview). Neuron. 2010;68(6):1015-1016. doi:10.1016/j.neuron.2010.12.011'
apa: 'Pleydell Bouverie, B., & Csicsvari, J. L. (2010). Rate remapping: When
the code goes beyond space (preview). Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2010.12.011'
chicago: 'Pleydell Bouverie, Barty, and Jozsef L Csicsvari. “Rate Remapping: When
the Code Goes beyond Space (Preview).” Neuron. Elsevier, 2010. https://doi.org/10.1016/j.neuron.2010.12.011.'
ieee: 'B. Pleydell Bouverie and J. L. Csicsvari, “Rate remapping: When the code
goes beyond space (preview),” Neuron, vol. 68, no. 6. Elsevier, pp. 1015–1016,
2010.'
ista: 'Pleydell Bouverie B, Csicsvari JL. 2010. Rate remapping: When the code goes
beyond space (preview). Neuron. 68(6), 1015–1016.'
mla: 'Pleydell Bouverie, Barty, and Jozsef L. Csicsvari. “Rate Remapping: When the
Code Goes beyond Space (Preview).” Neuron, vol. 68, no. 6, Elsevier, 2010,
pp. 1015–16, doi:10.1016/j.neuron.2010.12.011.'
short: B. Pleydell Bouverie, J.L. Csicsvari, Neuron 68 (2010) 1015–1016.
date_created: 2018-12-11T12:03:08Z
date_published: 2010-12-22T00:00:00Z
date_updated: 2019-05-10T12:19:51Z
day: '22'
doi: 10.1016/j.neuron.2010.12.011
extern: 1
intvolume: ' 68'
issue: '6'
month: '12'
page: 1015 - 1016
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2999'
quality_controlled: 0
status: public
title: 'Rate remapping: When the code goes beyond space (preview)'
type: review
volume: 68
year: '2010'
...
---
_id: '3547'
abstract:
- lang: eng
text: Neurons possess elaborate dendritic arbors which receive and integrate excitatory
synaptic signals. Individual dendritic subbranches exhibit local membrane potential
supralinearities, termed dendritic spikes, which control transfer of local synaptic
input to the soma. Here, we show that dendritic spikes in CA1 pyramidal cells
are strongly regulated by specific types of prior input. While input in the linear
range is without effect, supralinear input inhibits subsequent spikes, causing
them to attenuate and ultimately fail due to dendritic Na+ channel inactivation.
This mechanism acts locally within the boundaries of the input branch. If an input
is sufficiently strong to trigger axonal action potentials, their back-propagation
into the dendritic tree causes a widespread global reduction in dendritic excitability
which is prominent after firing patterns occurring in vivo. Together, these mechanisms
control the capability of individual dendritic branches to trigger somatic action
potential output. They are invoked at frequencies encountered during learning,
and impose limits on the storage and retrieval rates of information encoded as
branch excitability.
author:
- first_name: Stefan
full_name: Remy,Stefan
last_name: Remy
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Heinz
full_name: Beck,Heinz
last_name: Beck
citation:
ama: Remy S, Csicsvari JL, Beck H. Activity-dependent control of neuronal output
by local and global dendritic spike attenuation. Neuron. 2009;61(6):906-916.
doi:10.1016/j.neuron.2009.01.032
apa: Remy, S., Csicsvari, J. L., & Beck, H. (2009). Activity-dependent control
of neuronal output by local and global dendritic spike attenuation. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2009.01.032
chicago: Remy, Stefan, Jozsef L Csicsvari, and Heinz Beck. “Activity-Dependent Control
of Neuronal Output by Local and Global Dendritic Spike Attenuation.” Neuron.
Elsevier, 2009. https://doi.org/10.1016/j.neuron.2009.01.032.
ieee: S. Remy, J. L. Csicsvari, and H. Beck, “Activity-dependent control of neuronal
output by local and global dendritic spike attenuation,” Neuron, vol. 61,
no. 6. Elsevier, pp. 906–916, 2009.
ista: Remy S, Csicsvari JL, Beck H. 2009. Activity-dependent control of neuronal
output by local and global dendritic spike attenuation. Neuron. 61(6), 906–916.
mla: Remy, Stefan, et al. “Activity-Dependent Control of Neuronal Output by Local
and Global Dendritic Spike Attenuation.” Neuron, vol. 61, no. 6, Elsevier,
2009, pp. 906–16, doi:10.1016/j.neuron.2009.01.032.
short: S. Remy, J.L. Csicsvari, H. Beck, Neuron 61 (2009) 906–916.
date_created: 2018-12-11T12:03:54Z
date_published: 2009-03-26T00:00:00Z
date_updated: 2021-01-12T07:44:13Z
day: '26'
doi: 10.1016/j.neuron.2009.01.032
extern: 1
intvolume: ' 61'
issue: '6'
month: '03'
page: 906 - 916
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2838'
quality_controlled: 0
status: public
title: Activity-dependent control of neuronal output by local and global dendritic
spike attenuation
type: journal_article
volume: 61
year: '2009'
...
---
_id: '3520'
abstract:
- lang: eng
text: The hippocampus is thought to be involved in episodic memory formation by
reactivating traces of waking experience during sleep. Indeed, the joint firing
of spatially tuned pyramidal cells encoding nearby places recur during sleep.
We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places
increased relative to the sleep session before exploration. This cofiring increase
depended on the number of times that cells fired together with short latencies
( < 50 ms) during exploration, and was strongest between cells representing
the most visited places. This is indicative of a Hebbian learning rule in which
changes in firing associations between cells are determined by the number of waking
coincident firing events. In contrast, cells encoding different locations reduced
their cofiring in proportion to the number of times that they fired independently.
Together these data indicate that reactivated patterns are shaped by both positive
and negative changes in cofiring, which are determined by recent behavior.
author:
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Timothy
full_name: Senior,Timothy J
last_name: Senior
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: John
full_name: Huxter,John R
last_name: Huxter
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. Reactivation of experience-dependent
cell assembly patterns in the hippocampus. Nature Neuroscience. 2008;11(2):209-215.
doi:10.1038/nn2037
apa: O’Neill, J., Senior, T., Allen, K., Huxter, J., & Csicsvari, J. L. (2008).
Reactivation of experience-dependent cell assembly patterns in the hippocampus.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn2037
chicago: O’Neill, Joseph, Timothy Senior, Kevin Allen, John Huxter, and Jozsef L
Csicsvari. “Reactivation of Experience-Dependent Cell Assembly Patterns in the
Hippocampus.” Nature Neuroscience. Nature Publishing Group, 2008. https://doi.org/10.1038/nn2037.
ieee: J. O’Neill, T. Senior, K. Allen, J. Huxter, and J. L. Csicsvari, “Reactivation
of experience-dependent cell assembly patterns in the hippocampus,” Nature
Neuroscience, vol. 11, no. 2. Nature Publishing Group, pp. 209–215, 2008.
ista: O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. 2008. Reactivation of
experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience.
11(2), 209–215.
mla: O’Neill, Joseph, et al. “Reactivation of Experience-Dependent Cell Assembly
Patterns in the Hippocampus.” Nature Neuroscience, vol. 11, no. 2, Nature
Publishing Group, 2008, pp. 209–15, doi:10.1038/nn2037.
short: J. O’Neill, T. Senior, K. Allen, J. Huxter, J.L. Csicsvari, Nature Neuroscience
11 (2008) 209–215.
date_created: 2018-12-11T12:03:46Z
date_published: 2008-02-01T00:00:00Z
date_updated: 2021-01-12T07:44:02Z
day: '01'
doi: 10.1038/nn2037
extern: 1
intvolume: ' 11'
issue: '2'
month: '02'
page: 209 - 215
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '2864'
quality_controlled: 0
status: public
title: Reactivation of experience-dependent cell assembly patterns in the hippocampus
type: journal_article
volume: 11
year: '2008'
...
---
_id: '3537'
abstract:
- lang: eng
text: 'Hippocampal place cells that fire together within the same cycle of theta
oscillations represent the sequence of positions (movement trajectory) that a
rat traverses on a linear track. Furthermore, it has been suggested that the encoding
of these and other types of temporal memory sequences is organized by gamma oscillations
nested within theta oscillations. Here, we examined whether gamma-related firing
of place cells permits such discrete temporal coding. We found that gamma-modulated
CA1 pyramidal cells separated into two classes on the basis of gamma firing phases
during waking theta periods. These groups also differed in terms of their spike
waveforms, firing rates, and burst firing tendency. During gamma oscillations
one group''s firing became restricted to theta phases associated with the highest
gamma power. Consequently, on the linear track, cells in this group often failed
to fire early in theta-phase precession (as the rat entered the place field) if
gamma oscillations were present. The second group fired throughout the theta cycle
during gamma oscillations, and maintained gamma-modulated firing at different
stages of theta-phase precession. Our results suggest that the two different pyramidal
cell classes may support different types of population codes within a theta cycle:
one in which spike sequences representing movement trajectories occur across subsequent
gamma cycles nested within each theta cycle, and another in which firing in synchronized
gamma discharges without temporal sequences encode a representation of location.
We propose that gamma oscillations during theta-phase precession organize the
mnemonic recall of population patterns representing places and movement paths.'
author:
- first_name: Timothy
full_name: Senior,Timothy J
last_name: Senior
- first_name: John
full_name: Huxter,John R
last_name: Huxter
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. Gamma oscillatory firing
reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus.
Journal of Neuroscience. 2008;28(9):2274-2286. doi:10.1523/JNEUROSCI.4669-07.2008
apa: Senior, T., Huxter, J., Allen, K., O’Neill, J., & Csicsvari, J. L. (2008).
Gamma oscillatory firing reveals distinct populations of pyramidal cells in the
CA1 region of the hippocampus. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.4669-07.2008
chicago: Senior, Timothy, John Huxter, Kevin Allen, Joseph O’Neill, and Jozsef L
Csicsvari. “Gamma Oscillatory Firing Reveals Distinct Populations of Pyramidal
Cells in the CA1 Region of the Hippocampus.” Journal of Neuroscience. Society
for Neuroscience, 2008. https://doi.org/10.1523/JNEUROSCI.4669-07.2008.
ieee: T. Senior, J. Huxter, K. Allen, J. O’Neill, and J. L. Csicsvari, “Gamma oscillatory
firing reveals distinct populations of pyramidal cells in the CA1 region of the
hippocampus,” Journal of Neuroscience, vol. 28, no. 9. Society for Neuroscience,
pp. 2274–2286, 2008.
ista: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. 2008. Gamma oscillatory
firing reveals distinct populations of pyramidal cells in the CA1 region of the
hippocampus. Journal of Neuroscience. 28(9), 2274–2286.
mla: Senior, Timothy, et al. “Gamma Oscillatory Firing Reveals Distinct Populations
of Pyramidal Cells in the CA1 Region of the Hippocampus.” Journal of Neuroscience,
vol. 28, no. 9, Society for Neuroscience, 2008, pp. 2274–86, doi:10.1523/JNEUROSCI.4669-07.2008.
short: T. Senior, J. Huxter, K. Allen, J. O’Neill, J.L. Csicsvari, Journal of Neuroscience
28 (2008) 2274–2286.
date_created: 2018-12-11T12:03:51Z
date_published: 2008-02-27T00:00:00Z
date_updated: 2021-01-12T07:44:09Z
day: '27'
doi: 10.1523/JNEUROSCI.4669-07.2008
extern: 1
intvolume: ' 28'
issue: '9'
month: '02'
page: 2274 - 2286
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2847'
quality_controlled: 0
status: public
title: Gamma oscillatory firing reveals distinct populations of pyramidal cells in
the CA1 region of the hippocampus
type: journal_article
volume: 28
year: '2008'
...
---
_id: '3534'
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Barty
full_name: Pleydell-Bouverie, Barty
last_name: Pleydell Bouverie
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, Pleydell Bouverie B, Csicsvari JL. Inhibitory interneurons and network
oscillations. PNAS. 2008;105(47):18079-18080. doi:10.1073/pnas.0810064105
apa: Dupret, D., Pleydell Bouverie, B., & Csicsvari, J. L. (2008). Inhibitory
interneurons and network oscillations. PNAS. National Academy of Sciences.
https://doi.org/10.1073/pnas.0810064105
chicago: Dupret, David, Barty Pleydell Bouverie, and Jozsef L Csicsvari. “Inhibitory
Interneurons and Network Oscillations.” PNAS. National Academy of Sciences,
2008. https://doi.org/10.1073/pnas.0810064105.
ieee: D. Dupret, B. Pleydell Bouverie, and J. L. Csicsvari, “Inhibitory interneurons
and network oscillations,” PNAS, vol. 105, no. 47. National Academy of
Sciences, pp. 18079–18080, 2008.
ista: Dupret D, Pleydell Bouverie B, Csicsvari JL. 2008. Inhibitory interneurons
and network oscillations. PNAS. 105(47), 18079–18080.
mla: Dupret, David, et al. “Inhibitory Interneurons and Network Oscillations.” PNAS,
vol. 105, no. 47, National Academy of Sciences, 2008, pp. 18079–80, doi:10.1073/pnas.0810064105.
short: D. Dupret, B. Pleydell Bouverie, J.L. Csicsvari, PNAS 105 (2008) 18079–18080.
date_created: 2018-12-11T12:03:50Z
date_published: 2008-11-25T00:00:00Z
date_updated: 2021-01-12T07:44:08Z
day: '25'
doi: 10.1073/pnas.0810064105
extern: 1
intvolume: ' 105'
issue: '47'
month: '11'
page: 18079 - 18080
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2852'
quality_controlled: 0
status: public
title: Inhibitory interneurons and network oscillations
type: journal_article
volume: 105
year: '2008'
...
---
_id: '3516'
abstract:
- lang: eng
text: Temporal coding is a means of representing information by the time, as opposed
to the rate, at which neurons fire. Evidence of temporal coding in the hippocampus
comes from place cells, whose spike times relative to theta oscillations reflect
a rat's position while running along stereotyped trajectories. This arises from
the backwards shift in cell firing relative to local theta oscillations (phase
precession). Here we demonstrate phase precession during place-field crossings
in an open-field foraging task. This produced spike sequences in each theta cycle
that disambiguate the rat's trajectory through two-dimensional space and can be
used to predict movement direction. Furthermore, position and movement direction
were maximally predicted from firing in the early and late portions of the theta
cycle, respectively. This represents the first direct evidence of a combined representation
of position, trajectory and heading in the hippocampus, organized on a fine temporal
scale by theta oscillations.
author:
- first_name: John
full_name: Huxter,John R
last_name: Huxter
- first_name: Timothy
full_name: Senior,Timothy J
last_name: Senior
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Huxter J, Senior T, Allen K, Csicsvari JL. Theta phase-specific codes for two-dimensional
position, trajectory and heading in the hippocampus. Nature Neuroscience.
2008;11(5):587-594. doi:10.1038/nn.2106
apa: Huxter, J., Senior, T., Allen, K., & Csicsvari, J. L. (2008). Theta phase-specific
codes for two-dimensional position, trajectory and heading in the hippocampus.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.2106
chicago: Huxter, John, Timothy Senior, Kevin Allen, and Jozsef L Csicsvari. “Theta
Phase-Specific Codes for Two-Dimensional Position, Trajectory and Heading in the
Hippocampus.” Nature Neuroscience. Nature Publishing Group, 2008. https://doi.org/10.1038/nn.2106.
ieee: J. Huxter, T. Senior, K. Allen, and J. L. Csicsvari, “Theta phase-specific
codes for two-dimensional position, trajectory and heading in the hippocampus,”
Nature Neuroscience, vol. 11, no. 5. Nature Publishing Group, pp. 587–594,
2008.
ista: Huxter J, Senior T, Allen K, Csicsvari JL. 2008. Theta phase-specific codes
for two-dimensional position, trajectory and heading in the hippocampus. Nature
Neuroscience. 11(5), 587–594.
mla: Huxter, John, et al. “Theta Phase-Specific Codes for Two-Dimensional Position,
Trajectory and Heading in the Hippocampus.” Nature Neuroscience, vol. 11,
no. 5, Nature Publishing Group, 2008, pp. 587–94, doi:10.1038/nn.2106.
short: J. Huxter, T. Senior, K. Allen, J.L. Csicsvari, Nature Neuroscience 11 (2008)
587–594.
date_created: 2018-12-11T12:03:44Z
date_published: 2008-05-29T00:00:00Z
date_updated: 2021-01-12T07:44:00Z
day: '29'
doi: 10.1038/nn.2106
extern: 1
intvolume: ' 11'
issue: '5'
month: '05'
page: 587 - 594
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '2869'
quality_controlled: 0
status: public
title: Theta phase-specific codes for two-dimensional position, trajectory and heading
in the hippocampus
type: journal_article
volume: 11
year: '2008'
...
---
_id: '3530'
abstract:
- lang: eng
text: In the cerebral cortex, GABAergic interneurons are often regarded as fast-spiking
cells. We have identified a type of slow-spiking interneuron that offers distinct
contributions to network activity. “Ivy” cells, named after their dense and fine
axons innervating mostly basal and oblique pyramidal cell dendrites, are more
numerous than the parvalbumin-expressing basket, bistratified, or axo-axonic cells.
Ivy cells express nitric oxide synthase, neuropeptide Y, and high levels of GABA(A)
receptor alpha 1 subunit; they discharge at a low frequency with wide spikes in
vivo, yet are distinctively phase-locked to behaviorally relevant network rhythms
including theta, gamma, and ripple oscillations. Paired recordings in vitro showed
that Ivy cells receive depressing EPSPs from pyramidal cells, which in turn receive
slowly rising and decaying inhibitory input from Ivy cells. In contrast to fast-spiking
interneurons operating with millisecond precision, the highly abundant Ivy cells
express presynaptically acting neuromodulators and regulate the excitability of
pyramidal cell dendrites through slowly rising and decaying GABAergic inputs.
author:
- first_name: Pablo
full_name: Fuentealba,Pablo
last_name: Fuentealba
- first_name: Rahima
full_name: Begum,Rahima
last_name: Begum
- first_name: Marco
full_name: Capogna,Marco
last_name: Capogna
- first_name: Shozo
full_name: Jinno,Shozo
last_name: Jinno
- first_name: Laszlo
full_name: Marton,Laszlo F
last_name: Marton
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Alex
full_name: Thomson,Alex
last_name: Thomson
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
- first_name: Thomas
full_name: Klausberger,Thomas
last_name: Klausberger
citation:
ama: 'Fuentealba P, Begum R, Capogna M, et al. Ivy cells: A population of nitric-oxide-producing,
slow-spiking GABAergic neurons and their involvement in hippocampal network activity.
Neuron. 2008;57(6):917-929. doi:10.1016/j.neuron.2008.01.034'
apa: 'Fuentealba, P., Begum, R., Capogna, M., Jinno, S., Marton, L., Csicsvari,
J. L., … Klausberger, T. (2008). Ivy cells: A population of nitric-oxide-producing,
slow-spiking GABAergic neurons and their involvement in hippocampal network activity.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2008.01.034'
chicago: 'Fuentealba, Pablo, Rahima Begum, Marco Capogna, Shozo Jinno, Laszlo Marton,
Jozsef L Csicsvari, Alex Thomson, Péter Somogyi, and Thomas Klausberger. “Ivy
Cells: A Population of Nitric-Oxide-Producing, Slow-Spiking GABAergic Neurons
and Their Involvement in Hippocampal Network Activity.” Neuron. Elsevier,
2008. https://doi.org/10.1016/j.neuron.2008.01.034.'
ieee: 'P. Fuentealba et al., “Ivy cells: A population of nitric-oxide-producing,
slow-spiking GABAergic neurons and their involvement in hippocampal network activity,”
Neuron, vol. 57, no. 6. Elsevier, pp. 917–929, 2008.'
ista: 'Fuentealba P, Begum R, Capogna M, Jinno S, Marton L, Csicsvari JL, Thomson
A, Somogyi P, Klausberger T. 2008. Ivy cells: A population of nitric-oxide-producing,
slow-spiking GABAergic neurons and their involvement in hippocampal network activity.
Neuron. 57(6), 917–929.'
mla: 'Fuentealba, Pablo, et al. “Ivy Cells: A Population of Nitric-Oxide-Producing,
Slow-Spiking GABAergic Neurons and Their Involvement in Hippocampal Network Activity.”
Neuron, vol. 57, no. 6, Elsevier, 2008, pp. 917–29, doi:10.1016/j.neuron.2008.01.034.'
short: P. Fuentealba, R. Begum, M. Capogna, S. Jinno, L. Marton, J.L. Csicsvari,
A. Thomson, P. Somogyi, T. Klausberger, Neuron 57 (2008) 917–929.
date_created: 2018-12-11T12:03:49Z
date_published: 2008-03-27T00:00:00Z
date_updated: 2021-01-12T07:44:06Z
day: '27'
doi: 10.1016/j.neuron.2008.01.034
extern: 1
intvolume: ' 57'
issue: '6'
month: '03'
page: 917 - 929
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2855'
quality_controlled: 0
status: public
title: 'Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic
neurons and their involvement in hippocampal network activity'
type: journal_article
volume: 57
year: '2008'
...
---
_id: '3544'
abstract:
- lang: eng
text: In the subthalamic nucleus (STN) of Parkinson's disease (PD) patients, a pronounced
synchronization of oscillatory activity at beta frequencies (15-30 Hz) accompanies
movement difficulties. Abnormal beta oscillations and motor symptoms are concomitantly
and acutely suppressed by dopaminergic therapies, suggesting that these inappropriate
rhythms might also emerge acutely from disrupted dopamine transmission. The neural
basis of these abnormal beta oscillations is unclear, and how they might compromise
information processing, or how they arise, is unknown. Using a 6-hydroxydopamine-lesioned
rodent model of PD, we demonstrate that beta oscillations are inappropriately
exaggerated, compared with controls, in a brain-state-dependent manner after chronic
dopamine loss. Exaggerated beta oscillations are expressed at the levels of single
neurons and small neuronal ensembles, and are focally present and spatially distributed
within STN. They are also expressed in synchronous population activities, as evinced
by oscillatory local field potentials, in STN and cortex. Excessively synchronized
beta oscillations reduce the information coding capacity of STN neuronal ensembles,
which may contribute to parkinsonian motor impairment. Acute disruption of dopamine
transmission in control animals with antagonists of D-1/D-2 receptors did not
exaggerate STN or cortical beta oscillations. Moreover, beta oscillations were
not exaggerated until several days after 6-hydroxydopamine injections. Thus, contrary
to predictions, abnormally amplified beta oscillations in cortico-STN circuits
do not result simply from an acute absence of dopamine receptor stimulation, but
are instead delayed sequelae of chronic dopamine depletion. Targeting the plastic
processes underlying the delayed emergence of pathological beta oscillations after
continuing dopaminergic dysfunction may offer considerable therapeutic promise.
author:
- first_name: Nicolas
full_name: Mallet,Nicolas
last_name: Mallet
- first_name: Alek
full_name: Pogosyan,Alek
last_name: Pogosyan
- first_name: Andrew
full_name: Sharott,Andrew
last_name: Sharott
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: John
full_name: Bolam, John Paul
last_name: Bolam
- first_name: Peter
full_name: Brown,Peter
last_name: Brown
- first_name: Peter
full_name: Magill,Peter J
last_name: Magill
citation:
ama: Mallet N, Pogosyan A, Sharott A, et al. Disrupted dopamine transmission and
the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral
cortex. Journal of Neuroscience. 2008;28(18):4795-4806. doi:10.1523/JNEUROSCI.0123-08.2008
apa: Mallet, N., Pogosyan, A., Sharott, A., Csicsvari, J. L., Bolam, J., Brown,
P., & Magill, P. (2008). Disrupted dopamine transmission and the emergence
of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0123-08.2008
chicago: Mallet, Nicolas, Alek Pogosyan, Andrew Sharott, Jozsef L Csicsvari, John
Bolam, Peter Brown, and Peter Magill. “Disrupted Dopamine Transmission and the
Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral
Cortex.” Journal of Neuroscience. Society for Neuroscience, 2008. https://doi.org/10.1523/JNEUROSCI.0123-08.2008.
ieee: N. Mallet et al., “Disrupted dopamine transmission and the emergence
of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex,”
Journal of Neuroscience, vol. 28, no. 18. Society for Neuroscience, pp.
4795–4806, 2008.
ista: Mallet N, Pogosyan A, Sharott A, Csicsvari JL, Bolam J, Brown P, Magill P.
2008. Disrupted dopamine transmission and the emergence of exaggerated beta oscillations
in subthalamic nucleus and cerebral cortex. Journal of Neuroscience. 28(18), 4795–4806.
mla: Mallet, Nicolas, et al. “Disrupted Dopamine Transmission and the Emergence
of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex.”
Journal of Neuroscience, vol. 28, no. 18, Society for Neuroscience, 2008,
pp. 4795–806, doi:10.1523/JNEUROSCI.0123-08.2008.
short: N. Mallet, A. Pogosyan, A. Sharott, J.L. Csicsvari, J. Bolam, P. Brown, P.
Magill, Journal of Neuroscience 28 (2008) 4795–4806.
date_created: 2018-12-11T12:03:53Z
date_published: 2008-04-30T00:00:00Z
date_updated: 2021-01-12T07:44:12Z
day: '30'
doi: 10.1523/JNEUROSCI.0123-08.2008
extern: 1
intvolume: ' 28'
issue: '18'
month: '04'
page: 4795 - 4806
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2842'
quality_controlled: 0
status: public
title: Disrupted dopamine transmission and the emergence of exaggerated beta oscillations
in subthalamic nucleus and cerebral cortex
type: journal_article
volume: 28
year: '2008'
...
---
_id: '3523'
abstract:
- lang: eng
text: On the linear track, the recent firing sequences of CA1 place cells recur
during sharp wave/ripple patterns (SWRs) in a reverse temporal order [Foster &
Wilson (2006) Nature, 440, 680-683]. We have found similar reverse-order reactivation
during SWRs in open-field exploration where the firing sequence of cells varied
before each SWR. Both the onset times and the firing patterns of cells showed
a tendency for reversed sequences during SWRs. These effects were observed for
SWRs that occurred during exploration, but not for those during longer immobility
periods. Additionally, reverse reactivation was stronger when it was preceded
by higher speed (> 5 cm/s) run periods. The trend for reverse-order SWR reactivation
was not significantly different in familiar and novel environments, even though
SWR-associated firing rates of both pyramidal cells and interneurons were reduced
in novel environments as compared with familiar. During exploration-associated
SWRs (eSWR) place cells retain place-selective firing [O'Neill et al. (2006) Neuron,
49, 143-155]. Here, we have shown that each cell's firing onset was more delayed
and firing probability more reduced during eSWRs the further the rat was from
the middle of the cell's place field; that is, cells receiving less momentary
place-related excitatory drive fired later during SWR events. However, even controlling
for place field distance, the recent firing of cells was still significantly correlated
with SWR reactivation sequences. We therefore propose that both place-related
drive and the firing history of cells contribute to reverse reactivation during
eSWRs.
author:
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: Timothy
full_name: Senior,Timothy
last_name: Senior
citation:
ama: Csicsvari JL, O’Neill J, Allen K, Senior T. Place-selective firing contributes
to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in
open-field exploration. European Journal of Neuroscience. 2007;26(3):704-716.
doi:10.1111/j.1460-9568.2007.05684.x
apa: Csicsvari, J. L., O’Neill, J., Allen, K., & Senior, T. (2007). Place-selective
firing contributes to the reverse-order reactivation of CA1 pyramidal cells during
sharp waves in open-field exploration. European Journal of Neuroscience.
Wiley-Blackwell. https://doi.org/10.1111/j.1460-9568.2007.05684.x
chicago: Csicsvari, Jozsef L, Joseph O’Neill, Kevin Allen, and Timothy Senior. “Place-Selective
Firing Contributes to the Reverse-Order Reactivation of CA1 Pyramidal Cells during
Sharp Waves in Open-Field Exploration.” European Journal of Neuroscience.
Wiley-Blackwell, 2007. https://doi.org/10.1111/j.1460-9568.2007.05684.x.
ieee: J. L. Csicsvari, J. O’Neill, K. Allen, and T. Senior, “Place-selective firing
contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp
waves in open-field exploration,” European Journal of Neuroscience, vol.
26, no. 3. Wiley-Blackwell, pp. 704–716, 2007.
ista: Csicsvari JL, O’Neill J, Allen K, Senior T. 2007. Place-selective firing contributes
to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in
open-field exploration. European Journal of Neuroscience. 26(3), 704–716.
mla: Csicsvari, Jozsef L., et al. “Place-Selective Firing Contributes to the Reverse-Order
Reactivation of CA1 Pyramidal Cells during Sharp Waves in Open-Field Exploration.”
European Journal of Neuroscience, vol. 26, no. 3, Wiley-Blackwell, 2007,
pp. 704–16, doi:10.1111/j.1460-9568.2007.05684.x.
short: J.L. Csicsvari, J. O’Neill, K. Allen, T. Senior, European Journal of Neuroscience
26 (2007) 704–716.
date_created: 2018-12-11T12:03:46Z
date_published: 2007-08-01T00:00:00Z
date_updated: 2021-01-12T07:44:03Z
day: '01'
doi: 10.1111/j.1460-9568.2007.05684.x
extern: 1
intvolume: ' 26'
issue: '3'
month: '08'
page: 704 - 716
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2862'
quality_controlled: 0
status: public
title: Place-selective firing contributes to the reverse-order reactivation of CA1
pyramidal cells during sharp waves in open-field exploration
type: journal_article
volume: 26
year: '2007'
...
---
_id: '3522'
abstract:
- lang: eng
text: We observed sharp wave/ripples (SWR) during exploration within brief (<
2.4 s) interruptions of or during theta oscillations. CA1 network responses of
SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility
or sleep were similar. However, neuronal activity during eSWR was location dependent,
and eSWR-related firing was stronger inside the place field than outside. The
eSPW-related firing increase was stronger than the baseline increase inside compared
to outside, suggesting a “supralinear” summation of eSWR and place-selective inputs.
Pairs of cells with similar place fields and/or correlated firing during exploration
showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential
activation of place cells was not required for the reactivation of waking co-firing
patterns; cell pairs with symmetrical cross-correlations still showed reactivated
waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing
during eSWRs facilitates initial associations between cells with similar place
fields that enable place-related ensemble patterns to recur during subsequent
sleep-SWRs.
author:
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Timothy
full_name: Senior,Timothy
last_name: Senior
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Senior T, Csicsvari JL. Place-selective firing of CA1 pyramidal
cells during sharp wave/ripple network patterns in exploratory behavior. Neuron.
2006;49(1):143-155. doi:10.1016/j.neuron.2005.10.037
apa: O’Neill, J., Senior, T., & Csicsvari, J. L. (2006). Place-selective firing
of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory
behavior. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2005.10.037
chicago: O’Neill, Joseph, Timothy Senior, and Jozsef L Csicsvari. “Place-Selective
Firing of CA1 Pyramidal Cells during Sharp Wave/Ripple Network Patterns in Exploratory
Behavior.” Neuron. Elsevier, 2006. https://doi.org/10.1016/j.neuron.2005.10.037.
ieee: J. O’Neill, T. Senior, and J. L. Csicsvari, “Place-selective firing of CA1
pyramidal cells during sharp wave/ripple network patterns in exploratory behavior,”
Neuron, vol. 49, no. 1. Elsevier, pp. 143–155, 2006.
ista: O’Neill J, Senior T, Csicsvari JL. 2006. Place-selective firing of CA1 pyramidal
cells during sharp wave/ripple network patterns in exploratory behavior. Neuron.
49(1), 143–155.
mla: O’Neill, Joseph, et al. “Place-Selective Firing of CA1 Pyramidal Cells during
Sharp Wave/Ripple Network Patterns in Exploratory Behavior.” Neuron, vol.
49, no. 1, Elsevier, 2006, pp. 143–55, doi:10.1016/j.neuron.2005.10.037.
short: J. O’Neill, T. Senior, J.L. Csicsvari, Neuron 49 (2006) 143–155.
date_created: 2018-12-11T12:03:46Z
date_published: 2006-01-05T00:00:00Z
date_updated: 2021-01-12T07:44:03Z
day: '05'
doi: 10.1016/j.neuron.2005.10.037
extern: 1
intvolume: ' 49'
issue: '1'
month: '01'
page: 143 - 155
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2863'
quality_controlled: 0
status: public
title: Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network
patterns in exploratory behavior
type: journal_article
volume: 49
year: '2006'
...
---
_id: '3545'
abstract:
- lang: eng
text: The functional organization of the basal ganglia ( BG) is often defined according
to one of two opposing schemes. The first proposes multiple, essentially independent
channels of information processing. The second posits convergence and lateral
integration of striatal channels at the level of the globus pallidus ( GP). We
tested the hypothesis that these proposed aspects of functional connectivity within
the striatopallidal axis are dynamic and related to brain state. Local field potentials
( LFPs) were simultaneously recorded from multiple sites in striatum and GP in
anesthetized rats during slow-wave activity( SWA) and during global activation
evoked by sensory stimulation. Functional connectivity was inferred from comparative
analyses of the internuclear and intranuclear coherence between bipolar derivations
of LFPs. During prominent SWA, as shown in the electrocorticogram and local field
potentials in the basal ganglia, intranuclear coherence, and, thus, lateral functional
connectivity within striatum or globus pallidus was relatively weak. Furthermore,
the temporal coupling of LFPs recorded across these two nuclei involved functional
convergence at the level of GP. Global activation, indicated by a loss of SWA,
was accompanied by a rapid functional reorganization of the striatopallidal axis.
Prominent lateral functional connectivity developed within GP and, to a significantly
more constrained spatial extent, striatum. Additionally, functional convergence
on GP was no longer apparent, despite increased internuclear coherence. These
data demonstrate that functional connectivity within the BG is highly dynamic
and suggest that the relative expression of organizational principles, such as
parallel, independent processing channels, striatopallidal convergence, and lateral
integration within BG nuclei, is dependent on brain state.
author:
- first_name: Peter
full_name: Magill,Peter J
last_name: Magill
- first_name: Alek
full_name: Pogosyan,Alek
last_name: Pogosyan
- first_name: Andrew
full_name: Sharott,Andrew
last_name: Sharott
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: John
full_name: Bolam, John Paul
last_name: Bolam
- first_name: Peter
full_name: Brown,Peter
last_name: Brown
citation:
ama: Magill P, Pogosyan A, Sharott A, Csicsvari JL, Bolam J, Brown P. Changes in
functional connectivity within the rat striatopallidal axis during global brain
activation in vivo. Journal of Neuroscience. 2006;26(23):6318-6329. doi:10.1523/JNEUROSCI.0620-06.2006
apa: Magill, P., Pogosyan, A., Sharott, A., Csicsvari, J. L., Bolam, J., & Brown,
P. (2006). Changes in functional connectivity within the rat striatopallidal axis
during global brain activation in vivo. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0620-06.2006
chicago: Magill, Peter, Alek Pogosyan, Andrew Sharott, Jozsef L Csicsvari, John
Bolam, and Peter Brown. “Changes in Functional Connectivity within the Rat Striatopallidal
Axis during Global Brain Activation in Vivo.” Journal of Neuroscience.
Society for Neuroscience, 2006. https://doi.org/10.1523/JNEUROSCI.0620-06.2006.
ieee: P. Magill, A. Pogosyan, A. Sharott, J. L. Csicsvari, J. Bolam, and P. Brown,
“Changes in functional connectivity within the rat striatopallidal axis during
global brain activation in vivo,” Journal of Neuroscience, vol. 26, no.
23. Society for Neuroscience, pp. 6318–6329, 2006.
ista: Magill P, Pogosyan A, Sharott A, Csicsvari JL, Bolam J, Brown P. 2006. Changes
in functional connectivity within the rat striatopallidal axis during global brain
activation in vivo. Journal of Neuroscience. 26(23), 6318–6329.
mla: Magill, Peter, et al. “Changes in Functional Connectivity within the Rat Striatopallidal
Axis during Global Brain Activation in Vivo.” Journal of Neuroscience,
vol. 26, no. 23, Society for Neuroscience, 2006, pp. 6318–29, doi:10.1523/JNEUROSCI.0620-06.2006.
short: P. Magill, A. Pogosyan, A. Sharott, J.L. Csicsvari, J. Bolam, P. Brown, Journal
of Neuroscience 26 (2006) 6318–6329.
date_created: 2018-12-11T12:03:53Z
date_published: 2006-06-07T00:00:00Z
date_updated: 2021-01-12T07:44:13Z
day: '07'
doi: 10.1523/JNEUROSCI.0620-06.2006
extern: 1
intvolume: ' 26'
issue: '23'
month: '06'
page: 6318 - 6329
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2840'
quality_controlled: 0
status: public
title: Changes in functional connectivity within the rat striatopallidal axis during
global brain activation in vivo
type: journal_article
volume: 26
year: '2006'
...
---
_id: '3443'
abstract:
- lang: eng
text: In the hippocampal CA1 area, a relatively homogenous population of pyramidal
cells is accompanied by a diversity of GABAergic interneurons. Previously, we
found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum
moleculare cells, innervating different domains of pyramidal cells, have distinct
firing patterns during network oscillations in vivo. A second family of interneurons,
expressing cholecystokinin but not parvalbumin, is known to target the same domains
of pyramidal cells as do the parvalbumin cells. To test the temporal activity
of these independent and parallel GABAergic inputs, we recorded the precise spike
timing of identified cholecystokinin interneurons during hippocampal network oscillations
in anesthetized rats and determined their molecular expression profiles and synaptic
targets. The cells were cannabinoid receptor type 1 immunopositive. Contrary to
the stereotyped firing of parvalbumin interneurons, cholecystokinin-expressing
basket and dendrite-innervating cells discharge, on average, with 1.7 ± 2.0 Hz
during high-frequency ripple oscillations in an episode-dependent manner. During
theta oscillations, cholecystokinin- expressing interneurons fire with 8.8 ± 3.3
Hz at a characteristic time on the ascending phase of theta waves (155 ± 81°),
when place cells start firing in freely moving animals. The firing patterns of
some interneurons recorded in drug-free behaving rats were similar to cholecystokinin
cells in anesthetized animals. Our results demonstrate that cholecystokinin- and
parvalbumin-expressing interneurons make different contributions to network oscillations
and play distinct roles in different brain states. We suggest that the specific
spike timing of cholecystokinin interneurons and their sensitivity to endocannabinoids
might contribute to differentiate subgroups of pyramidal cells forming neuronal
assemblies, whereas parvalbumin interneurons contribute to synchronizing the entire
network. Copyright © 2005 Society for Neuroscience.
author:
- first_name: Thomas
full_name: Klausberger,Thomas
last_name: Klausberger
- first_name: Laszlo
full_name: Marton,Laszlo F
last_name: Marton
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jojanneke
full_name: Huck, Jojanneke H
last_name: Huck
- first_name: Yannis
full_name: Dalezios, Yannis
last_name: Dalezios
- first_name: Pablo
full_name: Fuentealba,Pablo
last_name: Fuentealba
- first_name: Wai
full_name: Suen, Wai Yee
last_name: Suen
- first_name: Edit
full_name: Papp, Edit Cs
last_name: Papp
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
citation:
ama: Klausberger T, Marton L, O’Neill J, et al. Complementary roles of cholecystokinin-
and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations.
Journal of Neuroscience. 2005;25(42):9782-9793. doi:10.1523/JNEUROSCI.3269-05.2005
apa: Klausberger, T., Marton, L., O’Neill, J., Huck, J., Dalezios, Y., Fuentealba,
P., … Somogyi, P. (2005). Complementary roles of cholecystokinin- and parvalbumin-expressing
GABAergic neurons in hippocampal network oscillations. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.3269-05.2005
chicago: Klausberger, Thomas, Laszlo Marton, Joseph O’Neill, Jojanneke Huck, Yannis
Dalezios, Pablo Fuentealba, Wai Suen, et al. “Complementary Roles of Cholecystokinin-
and Parvalbumin-Expressing GABAergic Neurons in Hippocampal Network Oscillations.”
Journal of Neuroscience. Society for Neuroscience, 2005. https://doi.org/10.1523/JNEUROSCI.3269-05.2005.
ieee: T. Klausberger et al., “Complementary roles of cholecystokinin- and
parvalbumin-expressing GABAergic neurons in hippocampal network oscillations,”
Journal of Neuroscience, vol. 25, no. 42. Society for Neuroscience, pp.
9782–9793, 2005.
ista: Klausberger T, Marton L, O’Neill J, Huck J, Dalezios Y, Fuentealba P, Suen
W, Papp E, Kaneko T, Watanabe M, Csicsvari JL, Somogyi P. 2005. Complementary
roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal
network oscillations. Journal of Neuroscience. 25(42), 9782–9793.
mla: Klausberger, Thomas, et al. “Complementary Roles of Cholecystokinin- and Parvalbumin-Expressing
GABAergic Neurons in Hippocampal Network Oscillations.” Journal of Neuroscience,
vol. 25, no. 42, Society for Neuroscience, 2005, pp. 9782–93, doi:10.1523/JNEUROSCI.3269-05.2005.
short: T. Klausberger, L. Marton, J. O’Neill, J. Huck, Y. Dalezios, P. Fuentealba,
W. Suen, E. Papp, T. Kaneko, M. Watanabe, J.L. Csicsvari, P. Somogyi, Journal
of Neuroscience 25 (2005) 9782–9793.
date_created: 2018-12-11T12:03:21Z
date_published: 2005-10-19T00:00:00Z
date_updated: 2021-01-12T07:43:30Z
day: '19'
doi: 10.1523/JNEUROSCI.3269-05.2005
extern: 1
intvolume: ' 25'
issue: '42'
month: '10'
page: 9782 - 9793
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2944'
quality_controlled: 0
status: public
title: Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic
neurons in hippocampal network oscillations
type: journal_article
volume: 25
year: '2005'
...
---
_id: '3536'
abstract:
- lang: eng
text: 'Genetic engineering of the mouse brain allows investigators to address novel
hypotheses in vivo. Because of the paucity of information on the network patterns
of the mouse hippocampus, we investigated the electrical patterns in the behaving
animal using multisite silicon probes and wire tetrodes. Theta (6-9 Hz) and gamma
(40-100 Hz) oscillations were present during exploration and rapid eye movement
sleep. Gamma power and theta power were comodulated and gamma power varied as
a function of the theta cycle. Pyramidal cells and putative interneurons were
phase-locked to theta oscillations. During immobility, consummatory behaviors
and slow-wave sleep, sharp waves were present in cornu ammonis region CA1 of the
hippocampus stratum radiatum associated with 140-200-Hz “ripples” in the pyramidal
cell layer and population burst of CA1 neurons. In the hilus, large-amplitude
“dentate spikes” occurred in association with increased discharge of hilar neurons.
The amplitude of field patterns was larger in the mouse than in the rat, likely
reflecting the higher neuron density in a smaller brain. We suggest that the main
hippocampal network patterns are mediated by similar pathways and mechanisms in
mouse and rat. '
author:
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
- first_name: Derek
full_name: Buhl, Derek L
last_name: Buhl
- first_name: Kenneth
full_name: Harris, Kenneth D
last_name: Harris
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Boldizsár
full_name: Czéh, Boldizsár
last_name: Czéh
- first_name: Alexei
full_name: Morozov, Alexei
last_name: Morozov
citation:
ama: Buzsáki G, Buhl D, Harris K, Csicsvari JL, Czéh B, Morozov A. Hippocampal network
patterns of activity in the mouse. Neuroscience. 2003;116(1):201-211. doi:10.1016/S0306-4522(02)00669-3
apa: Buzsáki, G., Buhl, D., Harris, K., Csicsvari, J. L., Czéh, B., & Morozov,
A. (2003). Hippocampal network patterns of activity in the mouse. Neuroscience.
Elsevier. https://doi.org/10.1016/S0306-4522(02)00669-3
chicago: Buzsáki, György, Derek Buhl, Kenneth Harris, Jozsef L Csicsvari, Boldizsár
Czéh, and Alexei Morozov. “Hippocampal Network Patterns of Activity in the Mouse.”
Neuroscience. Elsevier, 2003. https://doi.org/10.1016/S0306-4522(02)00669-3.
ieee: G. Buzsáki, D. Buhl, K. Harris, J. L. Csicsvari, B. Czéh, and A. Morozov,
“Hippocampal network patterns of activity in the mouse,” Neuroscience,
vol. 116, no. 1. Elsevier, pp. 201–211, 2003.
ista: Buzsáki G, Buhl D, Harris K, Csicsvari JL, Czéh B, Morozov A. 2003. Hippocampal
network patterns of activity in the mouse. Neuroscience. 116(1), 201–211.
mla: Buzsáki, György, et al. “Hippocampal Network Patterns of Activity in the Mouse.”
Neuroscience, vol. 116, no. 1, Elsevier, 2003, pp. 201–11, doi:10.1016/S0306-4522(02)00669-3.
short: G. Buzsáki, D. Buhl, K. Harris, J.L. Csicsvari, B. Czéh, A. Morozov, Neuroscience
116 (2003) 201–211.
date_created: 2018-12-11T12:03:50Z
date_published: 2003-01-15T00:00:00Z
date_updated: 2021-01-12T07:44:09Z
day: '15'
doi: 10.1016/S0306-4522(02)00669-3
extern: 1
intvolume: ' 116'
issue: '1'
month: '01'
page: 201 - 211
publication: Neuroscience
publication_status: published
publisher: Elsevier
publist_id: '2849'
quality_controlled: 0
status: public
title: Hippocampal network patterns of activity in the mouse
type: journal_article
volume: 116
year: '2003'
...
---
_id: '3526'
abstract:
- lang: eng
text: Neurons can produce action potentials with high temporal precision(1). A fundamental
issue is whether, and how, this capability is used in information processing.
According to the `cell assembly' hypothesis, transient synchrony of anatomically
distributed groups of neurons underlies processing of both external sensory input
and internal cognitive mechanisms(2-4). Accordingly, neuron populations should
be arranged into groups whose synchrony exceeds that predicted by common modulation
by sensory input. Here we find that the spike times of hippocampal pyramidal cells
can be predicted more accurately by using the spike times of simultaneously recorded
neurons in addition to the animals location in space. This improvement remained
when the spatial prediction was refined with a spatially dependent theta phase
modulation(5-8). The time window in which spike times are best predicted from
simultaneous peer activity is 10-30 ms, suggesting that cell assemblies are synchronized
at this timescale. Because this temporal window matches the membrane time constant
of pyramidal neurons(9), the period of the hippocampal gamma oscillation(10) and
the time window for synaptic plasticity(11), we propose that cooperative activity
at this timescale is optimal for information transmission and storage in cortical
circuits.
author:
- first_name: Kenneth
full_name: Harris, Kenneth D
last_name: Harris
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Harris K, Csicsvari JL, Hirase H, Dragoi G, Buzsáki G. Organization of cell
assemblies in the hippocampus. Nature. 2003;424(6948):552-556. doi:0.1038/nature01834
apa: Harris, K., Csicsvari, J. L., Hirase, H., Dragoi, G., & Buzsáki, G. (2003).
Organization of cell assemblies in the hippocampus. Nature. Nature Publishing
Group. https://doi.org/0.1038/nature01834
chicago: Harris, Kenneth, Jozsef L Csicsvari, Hajima Hirase, George Dragoi, and
György Buzsáki. “Organization of Cell Assemblies in the Hippocampus.” Nature.
Nature Publishing Group, 2003. https://doi.org/0.1038/nature01834.
ieee: K. Harris, J. L. Csicsvari, H. Hirase, G. Dragoi, and G. Buzsáki, “Organization
of cell assemblies in the hippocampus,” Nature, vol. 424, no. 6948. Nature
Publishing Group, pp. 552–556, 2003.
ista: Harris K, Csicsvari JL, Hirase H, Dragoi G, Buzsáki G. 2003. Organization
of cell assemblies in the hippocampus. Nature. 424(6948), 552–556.
mla: Harris, Kenneth, et al. “Organization of Cell Assemblies in the Hippocampus.”
Nature, vol. 424, no. 6948, Nature Publishing Group, 2003, pp. 552–56,
doi:0.1038/nature01834.
short: K. Harris, J.L. Csicsvari, H. Hirase, G. Dragoi, G. Buzsáki, Nature 424 (2003)
552–556.
date_created: 2018-12-11T12:03:47Z
date_published: 2003-07-31T00:00:00Z
date_updated: 2021-01-12T07:44:04Z
day: '31'
doi: 0.1038/nature01834
extern: 1
intvolume: ' 424'
issue: '6948'
month: '07'
page: 552 - 556
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '2859'
quality_controlled: 0
status: public
title: Organization of cell assemblies in the hippocampus
type: journal_article
volume: 424
year: '2003'
...
---
_id: '3529'
abstract:
- lang: eng
text: Parallel recording of neuronal activity in the behaving animal is a prerequisite
for our understanding of neuronal representation and storage of information. Here
we describe the development of micro-machined silicon microelectrode arrays for
unit and local field recordings. The two-dimensional probes with 96 or 64 recording
sites provided high-density recording of unit and field activity with minimal
tissue displacement or damage. The on-chip active circuit eliminated movement
and other artifacts and greatly reduced the weight of the headgear. The precise
geometry of the recording tips allowed for the estimation of the spatial location
of the recorded neurons and for high-resolution estimation of extracellular current
source density. Action potentials could be simultaneously recorded from the soma
and dendrites of the same neurons. Silicon technology is a promising approach
for high-density, high-resolution sampling of neuronal activity in both basic
research and prosthetic devices.
author:
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Darrell
full_name: Henze, Darrell A
last_name: Henze
- first_name: Brian
full_name: Jamieson, Brian G
last_name: Jamieson
- first_name: Kenneth
full_name: Harris, Kenneth D
last_name: Harris
- first_name: Anton
full_name: Sirota, Anton M
last_name: Sirota
- first_name: Peter
full_name: Bartho, Peter
last_name: Bartho
- first_name: Kensall
full_name: Wise, Kensall D
last_name: Wise
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Henze D, Jamieson B, et al. Massively parallel recording of unit
and local field potentials with silicon-based electrodes. Journal of Neurophysiology.
2003;90(2):1314-1323. doi:10.1152/jn.00116.2003
apa: Csicsvari, J. L., Henze, D., Jamieson, B., Harris, K., Sirota, A., Bartho,
P., … Buzsáki, G. (2003). Massively parallel recording of unit and local field
potentials with silicon-based electrodes. Journal of Neurophysiology. American
Physiological Society. https://doi.org/10.1152/jn.00116.2003
chicago: Csicsvari, Jozsef L, Darrell Henze, Brian Jamieson, Kenneth Harris, Anton
Sirota, Peter Bartho, Kensall Wise, and György Buzsáki. “Massively Parallel Recording
of Unit and Local Field Potentials with Silicon-Based Electrodes.” Journal
of Neurophysiology. American Physiological Society, 2003. https://doi.org/10.1152/jn.00116.2003.
ieee: J. L. Csicsvari et al., “Massively parallel recording of unit and local
field potentials with silicon-based electrodes,” Journal of Neurophysiology,
vol. 90, no. 2. American Physiological Society, pp. 1314–1323, 2003.
ista: Csicsvari JL, Henze D, Jamieson B, Harris K, Sirota A, Bartho P, Wise K, Buzsáki
G. 2003. Massively parallel recording of unit and local field potentials with
silicon-based electrodes. Journal of Neurophysiology. 90(2), 1314–1323.
mla: Csicsvari, Jozsef L., et al. “Massively Parallel Recording of Unit and Local
Field Potentials with Silicon-Based Electrodes.” Journal of Neurophysiology,
vol. 90, no. 2, American Physiological Society, 2003, pp. 1314–23, doi:10.1152/jn.00116.2003.
short: J.L. Csicsvari, D. Henze, B. Jamieson, K. Harris, A. Sirota, P. Bartho, K.
Wise, G. Buzsáki, Journal of Neurophysiology 90 (2003) 1314–1323.
date_created: 2018-12-11T12:03:48Z
date_published: 2003-08-01T00:00:00Z
date_updated: 2021-01-12T07:44:05Z
day: '01'
doi: 10.1152/jn.00116.2003
extern: 1
intvolume: ' 90'
issue: '2'
month: '08'
page: 1314 - 1323
publication: Journal of Neurophysiology
publication_status: published
publisher: American Physiological Society
publist_id: '2856'
quality_controlled: 0
status: public
title: Massively parallel recording of unit and local field potentials with silicon-based
electrodes
type: journal_article
volume: 90
year: '2003'
...
---
_id: '3528'
abstract:
- lang: eng
text: Gamma frequency oscillations (30-100 Hz) have been suggested to underlie various
cognitive and motor functions. Here, we examine the generation of gamma oscillation
currents in the hippocampus, using two-dimensional, 96-site silicon probes. Two
gamma generators were identified, one in the dentate gyrus and another in the
CA3-CA1 regions. The coupling strength between the two oscillators varied during
both theta and nontheta states. Both pyramidal cells and interneurons were phase-locked
to gamma waves. Anatomical connectivity, rather than physical distance, determined
the coupling strength of the oscillating neurons. CA3 pyramidal neurons discharged
CA3 and CA1 interneurons at latencies indicative of monosynaptic connections.
Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which
entrains the CA1 region via its interneurons.
author:
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Brian
full_name: Jamieson, Brian G
last_name: Jamieson
- first_name: Kensall
full_name: Wise, Kensall D
last_name: Wise
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Jamieson B, Wise K, Buzsáki G. Mechanisms of gamma oscillations
in the hippocampus of the behaving rat. Neuron. 2003;37(2):311-322. doi:10.1016/S0896-6273(02)01169-8
apa: Csicsvari, J. L., Jamieson, B., Wise, K., & Buzsáki, G. (2003). Mechanisms
of gamma oscillations in the hippocampus of the behaving rat. Neuron. Elsevier.
https://doi.org/10.1016/S0896-6273(02)01169-8
chicago: Csicsvari, Jozsef L, Brian Jamieson, Kensall Wise, and György Buzsáki.
“Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat.” Neuron.
Elsevier, 2003. https://doi.org/10.1016/S0896-6273(02)01169-8.
ieee: J. L. Csicsvari, B. Jamieson, K. Wise, and G. Buzsáki, “Mechanisms of gamma
oscillations in the hippocampus of the behaving rat,” Neuron, vol. 37,
no. 2. Elsevier, pp. 311–322, 2003.
ista: Csicsvari JL, Jamieson B, Wise K, Buzsáki G. 2003. Mechanisms of gamma oscillations
in the hippocampus of the behaving rat. Neuron. 37(2), 311–322.
mla: Csicsvari, Jozsef L., et al. “Mechanisms of Gamma Oscillations in the Hippocampus
of the Behaving Rat.” Neuron, vol. 37, no. 2, Elsevier, 2003, pp. 311–22,
doi:10.1016/S0896-6273(02)01169-8.
short: J.L. Csicsvari, B. Jamieson, K. Wise, G. Buzsáki, Neuron 37 (2003) 311–322.
date_created: 2018-12-11T12:03:48Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2021-01-12T07:44:05Z
day: '01'
doi: 10.1016/S0896-6273(02)01169-8
extern: 1
intvolume: ' 37'
issue: '2'
month: '01'
page: 311 - 322
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2857'
quality_controlled: 0
status: public
title: Mechanisms of gamma oscillations in the hippocampus of the behaving rat
type: journal_article
volume: 37
year: '2003'
...
---
_id: '3543'
abstract:
- lang: eng
text: Both neocortical and hippocampal networks organize the firing patterns of
their neurons by prominent oscillations during sleep, but the functional role
of these rhythms is not well understood. Here, we show a robust correlation of
neuronal discharges between the somatosensory cortex and hippocampus on both slow
and fine time scales in the mouse and rat. Neuronal bursts in deep cortical layers,
associated with sleep spindles and delta waves/slow rhythm, effectively triggered
hippocampal discharges related to fast (ripple) oscillations. We hypothesize that
oscillation-mediated temporal links coordinate specific information transfer between
neocortical and hippocampal cell assemblies. Such a neocortical-hippocampal interplay
may be important for memory consolidation.
author:
- first_name: Anton
full_name: Sirota, Anton M
last_name: Sirota
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Derek
full_name: Buhl, Derek L
last_name: Buhl
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Sirota A, Csicsvari JL, Buhl D, Buzsáki G. Communication between neocortex
and hippocampus during sleep in rodents. PNAS. 2003;100(4):2065-2069. doi:10.1073/pnas.0437938100
apa: Sirota, A., Csicsvari, J. L., Buhl, D., & Buzsáki, G. (2003). Communication
between neocortex and hippocampus during sleep in rodents. PNAS. National
Academy of Sciences. https://doi.org/10.1073/pnas.0437938100
chicago: Sirota, Anton, Jozsef L Csicsvari, Derek Buhl, and György Buzsáki. “Communication
between Neocortex and Hippocampus during Sleep in Rodents.” PNAS. National
Academy of Sciences, 2003. https://doi.org/10.1073/pnas.0437938100.
ieee: A. Sirota, J. L. Csicsvari, D. Buhl, and G. Buzsáki, “Communication between
neocortex and hippocampus during sleep in rodents,” PNAS, vol. 100, no.
4. National Academy of Sciences, pp. 2065–2069, 2003.
ista: Sirota A, Csicsvari JL, Buhl D, Buzsáki G. 2003. Communication between neocortex
and hippocampus during sleep in rodents. PNAS. 100(4), 2065–2069.
mla: Sirota, Anton, et al. “Communication between Neocortex and Hippocampus during
Sleep in Rodents.” PNAS, vol. 100, no. 4, National Academy of Sciences,
2003, pp. 2065–69, doi:10.1073/pnas.0437938100.
short: A. Sirota, J.L. Csicsvari, D. Buhl, G. Buzsáki, PNAS 100 (2003) 2065–2069.
date_created: 2018-12-11T12:03:53Z
date_published: 2003-02-18T00:00:00Z
date_updated: 2021-01-12T07:44:12Z
day: '18'
doi: 10.1073/pnas.0437938100
extern: 1
intvolume: ' 100'
issue: '4'
month: '02'
page: 2065 - 2069
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2841'
quality_controlled: 0
status: public
title: Communication between neocortex and hippocampus during sleep in rodents
type: journal_article
volume: 100
year: '2003'
...
---
_id: '3533'
abstract:
- lang: eng
text: 'Information in neuronal networks is thought to be represented by the rate
of discharge and the temporal relationship between the discharging neurons. The
discharge frequency of neurons is affected by their afferents and intrinsic properties,
and shows great individual variability. The temporal coordination of neurons is
greatly facilitated by network oscillations. In the hippocampus, population synchrony
fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase
almost 10-fold during sharp wave bursts. Despite these large changes in excitability
in the sub-second scale, longer-term (minute-scale) firing rates of individual
neurons are relatively constant in an unchanging environment. As a result, mean
hippocampal output remains stable over time. To understand the mechanisms responsible
for this homeostasis, we address the following issues: (i) Can firing rates of
single cells be modified? (ii) Once modified, what mechanism(s) can maintain the
changes? We show that firing rates of hippocampal pyramidal cells can be altered
in a novel environment and by Hebbian pairing of physiological input patterns
with postsynaptic burst discharge. We also illustrate a competition between single
spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold)
inputs decrease the ability of strong (''teaching'') inputs to induce a burst
discharge, we propose that the single spike versus burst competition presents
a homeostatic regulatory mechanism to maintain synaptic strength and, consequently,
firing rate in pyramidal cells.'
article_processing_charge: No
article_type: original
author:
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: D.
full_name: Henze, D.
last_name: Henze
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
citation:
ama: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. Homeostatic
maintenance of neuronal excitability by burst discharges in vivo. Cerebral
Cortex. 2002;12(9):893-899. doi:10.1093/cercor/12.9.893
apa: Buzsáki, G., Csicsvari, J. L., Dragoi, G., Harris, K., Henze, D., & Hirase,
H. (2002). Homeostatic maintenance of neuronal excitability by burst discharges
in vivo. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.9.893
chicago: Buzsáki, György, Jozsef L Csicsvari, George Dragoi, Kenneth Harris, D.
Henze, and Hajima Hirase. “Homeostatic Maintenance of Neuronal Excitability by
Burst Discharges in Vivo.” Cerebral Cortex. Oxford University Press, 2002.
https://doi.org/10.1093/cercor/12.9.893.
ieee: G. Buzsáki, J. L. Csicsvari, G. Dragoi, K. Harris, D. Henze, and H. Hirase,
“Homeostatic maintenance of neuronal excitability by burst discharges in vivo,”
Cerebral Cortex, vol. 12, no. 9. Oxford University Press, pp. 893–899,
2002.
ista: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. 2002. Homeostatic
maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex.
12(9), 893–899.
mla: Buzsáki, György, et al. “Homeostatic Maintenance of Neuronal Excitability by
Burst Discharges in Vivo.” Cerebral Cortex, vol. 12, no. 9, Oxford University
Press, 2002, pp. 893–99, doi:10.1093/cercor/12.9.893.
short: G. Buzsáki, J.L. Csicsvari, G. Dragoi, K. Harris, D. Henze, H. Hirase, Cerebral
Cortex 12 (2002) 893–899.
date_created: 2018-12-11T12:03:50Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-07-17T07:27:12Z
day: '01'
doi: 10.1093/cercor/12.9.893
extern: '1'
external_id:
pmid:
- '12183388'
intvolume: ' 12'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 893 - 899
pmid: 1
publication: Cerebral Cortex
publication_identifier:
issn:
- 1047-3211
publication_status: published
publisher: Oxford University Press
publist_id: '2851'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Homeostatic maintenance of neuronal excitability by burst discharges in vivo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '3546'
abstract:
- lang: eng
text: Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated
in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a
significantly stronger relationship among local (<140 <mu>m) pyramidal
neurons compared with distant (>300 mum) neurons during non-theta-associated
immobility and sleep but not during theta-associated running and walking. In contrast,
cross-correlation between local pyramidal cell-interneuron pairs was significantly
stronger than between distant pairs during theta oscillations but were similar
during non-theta-associated behaviors. We suggest that network state-dependent
functional clustering of neuronal activity emerges because of the differential
contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals
during theta and non-theta behaviors.
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent
states of the hippocampal network affect functional clustering of neurons. Journal
of Neuroscience. 2001;21(10). doi:10.1523/JNEUROSCI.21-10-j0003.2001
apa: Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., & Buzsáki, G.
(2001). Behavior-dependent states of the hippocampal network affect functional
clustering of neurons. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001
chicago: Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and
György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional
Clustering of Neurons.” Journal of Neuroscience. Society for Neuroscience,
2001. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001.
ieee: H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent
states of the hippocampal network affect functional clustering of neurons,” Journal
of Neuroscience, vol. 21, no. 10. Society for Neuroscience, 2001.
ista: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent
states of the hippocampal network affect functional clustering of neurons. Journal
of Neuroscience. 21(10).
mla: Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network
Affect Functional Clustering of Neurons.” Journal of Neuroscience, vol.
21, no. 10, Society for Neuroscience, 2001, doi:10.1523/JNEUROSCI.21-10-j0003.2001.
short: H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal
of Neuroscience 21 (2001).
date_created: 2018-12-11T12:03:54Z
date_published: 2001-05-15T00:00:00Z
date_updated: 2023-05-12T09:47:39Z
day: '15'
doi: 10.1523/JNEUROSCI.21-10-j0003.2001
extern: '1'
external_id:
pmid:
- '11319243'
intvolume: ' 21'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubmed.ncbi.nlm.nih.gov/11319243/
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2839'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Behavior-dependent states of the hippocampal network affect functional clustering
of neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '3540'
abstract:
- lang: eng
text: What determines the firing rate of cortical neurons in the absence of external
sensory input or motor behavior, such as during sleep? Hero we report that, in
a familiar environment, the discharge frequency of simultaneously recorded individual
CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated
across sleep-wake-steep sequences. However, both measures were affected when new
sets of neurons were activated in a novel environment. Nevertheless, the grand
mean firing rate of the whole pyramidal cell population remained constant across
behavioral states and testing conditions. The findings suggest that long-term
firing patterns of single cells can be modified by experience. We hypothesize
that increased firing rates of recently used neurons are associated with a concomitant
decrease in the discharge activity of the remaining population, leaving the mean
excitability of the hippocampal network unaltered.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671, the F. M. Kirby Foundation, the Human Frontier Science Program (X.L.),
and the Uehara Memorial Foundation (H.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. Firing rates of
hippocampal neurons are preserved during subsequent sleep episodes and modified
by novel awake experience. PNAS. 2001;98(16):9386-9390. doi:10.1073/pnas.161274398
apa: Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J. L., & Buzsáki, G.
(2001). Firing rates of hippocampal neurons are preserved during subsequent sleep
episodes and modified by novel awake experience. PNAS. National Academy
of Sciences. https://doi.org/10.1073/pnas.161274398
chicago: Hirase, Hajima, Xavier Leinekugel, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent
Sleep Episodes and Modified by Novel Awake Experience.” PNAS. National
Academy of Sciences, 2001. https://doi.org/10.1073/pnas.161274398.
ieee: H. Hirase, X. Leinekugel, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing
rates of hippocampal neurons are preserved during subsequent sleep episodes and
modified by novel awake experience,” PNAS, vol. 98, no. 16. National Academy
of Sciences, pp. 9386–9390, 2001.
ista: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. 2001. Firing rates
of hippocampal neurons are preserved during subsequent sleep episodes and modified
by novel awake experience. PNAS. 98(16), 9386–9390.
mla: Hirase, Hajima, et al. “Firing Rates of Hippocampal Neurons Are Preserved during
Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS,
vol. 98, no. 16, National Academy of Sciences, 2001, pp. 9386–90, doi:10.1073/pnas.161274398.
short: H. Hirase, X. Leinekugel, A. Czurkó, J.L. Csicsvari, G. Buzsáki, PNAS 98
(2001) 9386–9390.
date_created: 2018-12-11T12:03:52Z
date_published: 2001-07-31T00:00:00Z
date_updated: 2023-05-12T10:07:41Z
day: '31'
doi: 10.1073/pnas.161274398
extern: '1'
external_id:
pmid:
- '11470910'
intvolume: ' 98'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55430/
month: '07'
oa: 1
oa_version: Published Version
page: 9386 - 9390
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2846'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Firing rates of hippocampal neurons are preserved during subsequent sleep episodes
and modified by novel awake experience
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 98
year: '2001'
...
---
_id: '3517'
abstract:
- lang: eng
text: 'A modular multichannel microdrive (''hyperdrive'') is described. The microdrive
uses printed circuit board technology and flexible fused silica capillaries. The
modular design allows for the fabrication of 4-32 independently movable electrodes
or `tetrodes''. The drives are re-usable and re-loading the drive with electrodes
is simple. '
article_processing_charge: No
article_type: original
author:
- first_name: Imre
full_name: Szabo, Imre
last_name: Szabo
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. The application
of printed circuit board technology for fabrication of multi-channel micro-drives.
Journal of Neuroscience Methods. 2001;105(1):105-110. doi:10.1016/S0165-0270(00)00362-9
apa: Szabo, I., Czurkó, A., Csicsvari, J. L., Hirase, H., Leinekugel, X., &
Buzsáki, G. (2001). The application of printed circuit board technology for fabrication
of multi-channel micro-drives. Journal of Neuroscience Methods. Elsevier.
https://doi.org/10.1016/S0165-0270(00)00362-9
chicago: Szabo, Imre, András Czurkó, Jozsef L Csicsvari, Hajima Hirase, Xavier Leinekugel,
and György Buzsáki. “The Application of Printed Circuit Board Technology for Fabrication
of Multi-Channel Micro-Drives.” Journal of Neuroscience Methods. Elsevier,
2001. https://doi.org/10.1016/S0165-0270(00)00362-9.
ieee: I. Szabo, A. Czurkó, J. L. Csicsvari, H. Hirase, X. Leinekugel, and G. Buzsáki,
“The application of printed circuit board technology for fabrication of multi-channel
micro-drives,” Journal of Neuroscience Methods, vol. 105, no. 1. Elsevier,
pp. 105–110, 2001.
ista: Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. 2001.
The application of printed circuit board technology for fabrication of multi-channel
micro-drives. Journal of Neuroscience Methods. 105(1), 105–110.
mla: Szabo, Imre, et al. “The Application of Printed Circuit Board Technology for
Fabrication of Multi-Channel Micro-Drives.” Journal of Neuroscience Methods,
vol. 105, no. 1, Elsevier, 2001, pp. 105–10, doi:10.1016/S0165-0270(00)00362-9.
short: I. Szabo, A. Czurkó, J.L. Csicsvari, H. Hirase, X. Leinekugel, G. Buzsáki,
Journal of Neuroscience Methods 105 (2001) 105–110.
date_created: 2018-12-11T12:03:45Z
date_published: 2001-01-30T00:00:00Z
date_updated: 2023-05-15T10:50:39Z
day: '30'
doi: 10.1016/S0165-0270(00)00362-9
extern: '1'
external_id:
pmid:
- '11166371'
intvolume: ' 105'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 105 - 110
pmid: 1
publication: Journal of Neuroscience Methods
publication_identifier:
issn:
- 0165-0270
publication_status: published
publisher: Elsevier
publist_id: '2868'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The application of printed circuit board technology for fabrication of multi-channel
micro-drives
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 105
year: '2001'
...
---
_id: '3548'
abstract:
- lang: eng
text: Simultaneous recording from large numbers of neurons is a prerequisite for
understanding their cooperative behavior. Various recording techniques and spike
separation methods are being used toward this goal. However, the error rates involved
in spike separation have not yet been quantified. We studied the separation reliability
of “tetrode” (4-wire electrode) recorded spikes by monitoring simultaneously from
the same cell intracellularly with a glass pipette and extracellularly with a
tetrode. With manual spike sorting, we found a trade-off between Type I and Type
II errors, with errors typically ranging from 0 to 30% depending on the amplitude
and firing pattern of the cell, the similarity of the waveshapes of neighboring
neurons, and the experience of the operator. Performance using only a single wire
was markedly lower, indicating the advantages of multiple-site monitoring techniques
over single-wire recordings. For tetrode recordings, error rates were increased
by burst activity and during periods of cellular synchrony. The lowest possible
separation error rates were estimated by a search for the best ellipsoidal cluster
shape. Human operator performance was significantly below the estimated optimum.
Investigation of error distributions indicated that suboptimal performance was
caused by inability of the operators to mark cluster boundaries accurately in
a high-dimensional feature space. We therefore hypothesized that automatic spike-sorting
algorithms have the potential to significantly lower error rates. Implementation
of a semi-automatic classification system confirms this suggestion, reducing errors
close to the estimated optimum, in the range 0-8%.
acknowledgement: The costs of publication of this article were defrayed in part by
the payment of page charges. The article must therefore be hereby marked ‘‘advertisement’
’in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. We thank
R. Bruno for performing cluster analysis and drawing our attention to the AutoClass
program, M. Recce and P. Mitra for suggestions withdata analysis and comments on
the manuscript, C. King, G. Dragoi, and X.Leinekugel for performing cluster analysis,
and J. Hetke and K. Wise for supplying silicon probes. The data used in this paper
are available on request by e-mail to G. Buzsaki. This work was supported by National
Institutes of Health Grants NS-34994,413 MH-54671, and MH-12403 (to D. A. Henze)
and by the Epilepsy Foundationof America (to D. A. Henze).
article_processing_charge: No
article_type: original
author:
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. Accuracy of tetrode spike
separation as determined by simultaneous intracellular and extracellular measurements.
Journal of Neurophysiology. 2000;84(1):401-414. doi:10.1152/jn.2000.84.1.401
apa: Harris, K., Henze, D., Csicsvari, J. L., Hirase, H., & Buzsáki, G. (2000).
Accuracy of tetrode spike separation as determined by simultaneous intracellular
and extracellular measurements. Journal of Neurophysiology. American Physiological
Society. https://doi.org/10.1152/jn.2000.84.1.401
chicago: Harris, Kenneth, Darrell Henze, Jozsef L Csicsvari, Hajima Hirase, and
György Buzsáki. “Accuracy of Tetrode Spike Separation as Determined by Simultaneous
Intracellular and Extracellular Measurements.” Journal of Neurophysiology.
American Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.401.
ieee: K. Harris, D. Henze, J. L. Csicsvari, H. Hirase, and G. Buzsáki, “Accuracy
of tetrode spike separation as determined by simultaneous intracellular and extracellular
measurements,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological
Society, pp. 401–414, 2000.
ista: Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. 2000. Accuracy of tetrode
spike separation as determined by simultaneous intracellular and extracellular
measurements. Journal of Neurophysiology. 84(1), 401–414.
mla: Harris, Kenneth, et al. “Accuracy of Tetrode Spike Separation as Determined
by Simultaneous Intracellular and Extracellular Measurements.” Journal of Neurophysiology,
vol. 84, no. 1, American Physiological Society, 2000, pp. 401–14, doi:10.1152/jn.2000.84.1.401.
short: K. Harris, D. Henze, J.L. Csicsvari, H. Hirase, G. Buzsáki, Journal of Neurophysiology
84 (2000) 401–414.
date_created: 2018-12-11T12:03:54Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-05-02T14:16:45Z
day: '01'
doi: 10.1152/jn.2000.84.1.401
extern: '1'
external_id:
pmid:
- '10899214 '
intvolume: ' 84'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 401 - 414
pmid: 1
publication: Journal of Neurophysiology
publication_identifier:
issn:
- 0022-3077
publication_status: published
publisher: American Physiological Society
publist_id: '2837'
quality_controlled: '1'
status: public
title: Accuracy of tetrode spike separation as determined by simultaneous intracellular
and extracellular measurements
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '3532'
abstract:
- lang: eng
text: Multichannel tetrode array recording in awake behaving animals provides a
powerful method to record the activity of large numbers of neurons. The power
of this method could be extended if further information concerning the intracellular
state of the neurons could be extracted from the extracellularly recorded signals.
Toward this end, we have simultaneously recorded intracellular and extracellular
signals from hippocampal CA1 pyramidal cells and interneurons in the anesthetized
rat. We found that several intracellular parameters can be deduced from extracellular
spike waveforms. The width of the intracellular action potential is defined precisely
by distinct points on the extracellular spike. Amplitude changes of the intracellular
action potential are reflected by changes in the amplitude of the initial negative
phase of the extracellular spike, and these amplitude changes are dependent on
the state of the network. In addition, intracellular recordings from dendrites
with simultaneous extracellular recordings from the soma indicate that, on average,
action potentials are initiated in the perisomatic region and propagate to the
dendrites at 1.68 m/s. Finally we determined that a tetrode in hippocampal area
CA1 theoretically should be able to record electrical signals from similar to
1,000 neurons. Of these, 60-100 neurons should generate spikes of sufficient amplitude
to be detectable from the noise and to allow for their separation using current
spatial clustering methods. This theoretical maximum is in contrast to the approximately
six units that are usually detected per tetrode. From this, we conclude that a
large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral
condition.
acknowledgement: We thank M. Recce for comments on the manuscript and J. Hetke and
K.Wise for supplying us with the silicon probes (1P41RR09754).This work was supported
by National Institutes of Health Grants NS-34994,MH-54671, and MH-12403 (to D.
A. Henze), the Epilepsy Foundation of American (D. A.Henze), and an Eotvos fellowship
(Z. Borhegyi).
article_processing_charge: No
article_type: original
author:
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Zsolt
full_name: Borhegyi, Zsolt
last_name: Borhegyi
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. Intracellular
features predicted by extracellular recordings in the hippocampus in vivo. Journal
of Neurophysiology. 2000;84(1):390-400. doi:10.1152/jn.2000.84.1.390
apa: Henze, D., Borhegyi, Z., Csicsvari, J. L., Mamiya, A., Harris, K., & Buzsáki,
G. (2000). Intracellular features predicted by extracellular recordings in the
hippocampus in vivo. Journal of Neurophysiology. American Physiological
Society. https://doi.org/10.1152/jn.2000.84.1.390
chicago: Henze, Darrell, Zsolt Borhegyi, Jozsef L Csicsvari, Akira Mamiya, Kenneth
Harris, and György Buzsáki. “Intracellular Features Predicted by Extracellular
Recordings in the Hippocampus in Vivo.” Journal of Neurophysiology. American
Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.390.
ieee: D. Henze, Z. Borhegyi, J. L. Csicsvari, A. Mamiya, K. Harris, and G. Buzsáki,
“Intracellular features predicted by extracellular recordings in the hippocampus
in vivo,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological
Society, pp. 390–400, 2000.
ista: Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. 2000. Intracellular
features predicted by extracellular recordings in the hippocampus in vivo. Journal
of Neurophysiology. 84(1), 390–400.
mla: Henze, Darrell, et al. “Intracellular Features Predicted by Extracellular Recordings
in the Hippocampus in Vivo.” Journal of Neurophysiology, vol. 84, no. 1,
American Physiological Society, 2000, pp. 390–400, doi:10.1152/jn.2000.84.1.390.
short: D. Henze, Z. Borhegyi, J.L. Csicsvari, A. Mamiya, K. Harris, G. Buzsáki,
Journal of Neurophysiology 84 (2000) 390–400.
date_created: 2018-12-11T12:03:49Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-05-02T14:31:13Z
day: '01'
doi: 10.1152/jn.2000.84.1.390
extern: '1'
external_id:
pmid:
- '10899213'
intvolume: ' 84'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 390 - 400
pmid: 1
publication: Journal of Neurophysiology
publication_identifier:
issn:
- 0022-3077
publication_status: published
publisher: American Physiological Society
publist_id: '2854'
quality_controlled: '1'
status: public
title: Intracellular features predicted by extracellular recordings in the hippocampus
in vivo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '3542'
abstract:
- lang: eng
text: Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous
recording of neuronal ensembles in the behaving rat. A nonlinear interaction among
pyramidal neurons was observed during sharp wave (SPW)-related population bursts,
with stronger synchrony associated with more widespread spatial coherence. SPW
bursts emerged in the CA3a-b subregions and spread to CA3c before invading the
CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was
required to exert a detectable influence on CA1 pyramidal cells. Activity of some
CA3 pyramidal neurons differentially predicted the ripple-related discharge of
circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral
state, the coherent discharge of a small group of CA3 cells is the primary cause
of spiking activity in CA1 pyramidal neurons.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. Ensemble patterns of hippocampal
CA3-CA1 neurons during sharp wave-associated population events. Neuron.
2000;28(2):585-594. doi:10.1016/S0896-6273(00)00135-5
apa: Csicsvari, J. L., Hirase, H., Mamiya, A., & Buzsáki, G. (2000). Ensemble
patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population
events. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00135-5
chicago: Csicsvari, Jozsef L, Hajima Hirase, Akira Mamiya, and György Buzsáki. “Ensemble
Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population
Events.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00135-5.
ieee: J. L. Csicsvari, H. Hirase, A. Mamiya, and G. Buzsáki, “Ensemble patterns
of hippocampal CA3-CA1 neurons during sharp wave-associated population events,”
Neuron, vol. 28, no. 2. Elsevier, pp. 585–594, 2000.
ista: Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. 2000. Ensemble patterns of hippocampal
CA3-CA1 neurons during sharp wave-associated population events. Neuron. 28(2),
585–594.
mla: Csicsvari, Jozsef L., et al. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons
during Sharp Wave-Associated Population Events.” Neuron, vol. 28, no. 2,
Elsevier, 2000, pp. 585–94, doi:10.1016/S0896-6273(00)00135-5.
short: J.L. Csicsvari, H. Hirase, A. Mamiya, G. Buzsáki, Neuron 28 (2000) 585–594.
date_created: 2018-12-11T12:03:52Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-02T14:26:07Z
day: '01'
doi: 10.1016/S0896-6273(00)00135-5
extern: '1'
intvolume: ' 28'
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 585 - 594
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2843'
quality_controlled: '1'
status: public
title: Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated
population events
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '2000'
...
---
_id: '3445'
abstract:
- lang: eng
text: The medial septal region and the hippocampus are connected reciprocally via
GABAergic neurons, but the physiological role of this loop is still not well understood.
In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic
projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta
activity and extracellular units recorded in the medial septum and diagonal band
of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%)
were significantly suppressed during SPWs. Most cells inhibited during SPW (80%)
fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal
layer theta waves. Because both SPW and the negative peak of local theta waves
correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron
classes, the findings indicate that the activity of medial septal neurons can
be negatively (during SPW) or positively (during theta waves) correlated with
the activity of hippocampal interneurons. We hypothesize that the functional coupling
between medial septal neurons and hippocampal interneurons varies in a state-dependent
manner.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and
support and T. F. Freund for his comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Daniel
full_name: Carpi, Daniel
last_name: Carpi
- first_name: Michael
full_name: Recce, Michael
last_name: Recce
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus
and medial septum during sharp waves and theta oscillation in the behaving rat.
Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999
apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999).
Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György
Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves
and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society
for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.
ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions
between hippocampus and medial septum during sharp waves and theta oscillation
in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society
for Neuroscience, pp. 6191–6199, 1999.
ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between
hippocampus and medial septum during sharp waves and theta oscillation in the
behaving rat. Journal of Neuroscience. 19(14), 6191–6199.
mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum
during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience,
vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.
short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience
19 (1999) 6191–6199.
date_created: 2018-12-11T12:03:22Z
date_published: 1999-07-15T00:00:00Z
date_updated: 2022-09-07T13:37:41Z
day: '15'
doi: 10.1523/JNEUROSCI.19-14-06191.1999
extern: '1'
external_id:
pmid:
- '10407055'
intvolume: ' 19'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/
month: '07'
oa: 1
oa_version: Published Version
page: 6191 - 6199
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3444'
abstract:
- lang: eng
text: This study examined intermittent, high-frequency (100-200 Hz) oscillatory
patterns in the CA1 region of the hippocampus in the absence of theta activity,
i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal
activity was phase-locked not only to large amplitude (>7 SD from baseline)
oscillatory events, which are present mainly during SPWs, but to smaller amplitude
(<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple"
frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz
("slow") oscillatory patterns. Fast ripple waves reversed just below
the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum
radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated
CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves.
These findings suggest that fast ripples emerge in the CA1 region, whereas slow
(100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred
to the CA1 field.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations
in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience.
1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Fast network oscillations in the hippocampal CA1 region of the behaving rat.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the
Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network
oscillations in the hippocampal CA1 region of the behaving rat,” Journal
of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network
oscillations in the hippocampal CA1 region of the behaving rat. Journal of
Neuroscience. 19(16).
mla: Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal
CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no.
16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999).
date_created: 2018-12-11T12:03:22Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:41:18Z
day: '15'
doi: 10.1523/JNEUROSCI.19-16-j0001.1999
extern: '1'
external_id:
pmid:
- '10436076'
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast network oscillations in the hippocampal CA1 region of the behaving
rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3524'
abstract:
- lang: eng
text: We examined whether excitation and inhibition are balanced in hippocampal
cortical networks. Extracellular field and single-unit activity were recorded
by multiple tetrodes and multisite silicon probes to reveal the timing of the
activity of hippocampal CAI pyramidal cells and classes of interneurons during
theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and
dendritic inhibition of pyramidal cells was deduced from the activity of interneurons
in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively.
int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population
discharge of pyramidal cells during the theta cycle, respectively. SPW ripples
were associated with a 2.5-fold net increase of excitation. The discharge frequency
of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent”
cells) during SPW suggesting that not all interneurons are innervated by pyramidal
cells. Int(p) either fired together with (unimodal cells) or both before and after
(bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the
activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum
discharge probability of pyramidal neurons by 1-2 msec. Network state changes,
as reflected by field activity, covaried with changes in the spike train dynamics
of single cells and their interactions. Summed activity of parallel-recorded interneurons,
but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse
was true for the ripple cycles of SPWs. We suggest that network-driven excitability
changes provide temporal windows of opportunity for single pyramidal cells to
suppress, enable, or facilitate selective synaptic inputs.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994,
MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell
A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and
Ken Wise for supplying us with silicon probes.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal
of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving
rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons
in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience,
1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory
coupling of hippocampal pyramidal cells and interneurons in the behaving rat,”
Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp.
274–287, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of
Neuroscience. 19(1), 274–287.
mla: Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal
Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol.
19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999) 274–287.
date_created: 2018-12-11T12:03:47Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T10:00:45Z
day: '01'
doi: 10.1523/JNEUROSCI.19-01-00274.1999
extern: '1'
external_id:
pmid:
- '9870957'
intvolume: ' 19'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/
month: '01'
oa: 1
oa_version: Published Version
page: 274 - 287
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2860'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oscillatory coupling of hippocampal pyramidal cells and interneurons in the
behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3518'
abstract:
- lang: eng
text: Information in neuronal networks may be represented by the spatiotemporal
patterns of spikes. Here we examined the temporal coordination of pyramidal cell
spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained
to run in a defined position in space (running wheel) to activate a selected group
of pyramidal cells. A template-matching method and a joint probability map method
were used for sequence search. Repeating spike sequences in excess of chance occurrence
were examined by comparing the number of repeating sequences in the original spike
trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four
different shuffling procedures were used to control for the population dynamics
of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies
were present in both the awake and sleeping animal in excess of what might be
predicted by random variations. Spike sequences observed during wheel running
were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave
sleep. We hypothesize that the endogenously expressed spike sequences during sleep
reflect reactivation of the circuitry modified by previous experience. Reactivation
of acquired sequences may serve to consolidate information.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale
Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and
Matthew Wilson for their suggestions with data analysis and comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression
of recurring spike sequences in the hippocampus. Journal of Neuroscience.
1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999
apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999).
Replay and time compression of recurring spike sequences in the hippocampus. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the
Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.
ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay
and time compression of recurring spike sequences in the hippocampus,” Journal
of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507,
1999.
ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time
compression of recurring spike sequences in the hippocampus. Journal of Neuroscience.
19(21), 9497–9507.
mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences
in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society
for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.
short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of
Neuroscience 19 (1999) 9497–9507.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-11-01T00:00:00Z
date_updated: 2022-09-07T12:48:08Z
day: '01'
doi: 10.1523/JNEUROSCI.19-21-09497.1999
extern: '1'
external_id:
pmid:
- '10531452'
intvolume: ' 19'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/
month: '11'
oa: 1
oa_version: Published Version
page: 9497 - 9507
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2866'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replay and time compression of recurring spike sequences in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3519'
abstract:
- lang: eng
text: 'In contrast to sensory cortical areas of the brain, the relevant physiological
inputs to the hippocampus, leading to selective activation of pyramidal cells,
are largely unknown. Pyramidal cells are thought to be phasically activated by
spatial cues and a variety of sensory and motor stimuli. Here, we used a behavioural
`space clamp'' method, which involved the confinement of the actively running
animal in a defined position in space (running wheel) and kept sensory inputs
constant. Twelve percent of the recorded CA1 pyramidal cells were selectively
active while the rat was running in the wheel. Cell firing was specific to the
direction of running and disappeared after rotating the recording apparatus. The
discharge frequency of pyramidal cells and interneurons was sustained as long
as the rat ran continuously in the wheel. Furthermore, the discharge frequency
of pyramidal cells and interneurons increased with increasing running velocity,
even though the frequency of hippocampal theta waves remained constant. The discharge
frequency of some `wheel-related'' pyramidal cells could increase more than 10-fold
between 10 and 100 cm/s, whereas the firing rate of `non-wheel'' cells remained
constantly low. We hypothesize that: (i) a necessary condition for place-specific
discharge of hippocampal pyramidal cells is the presence of theta oscillation;
and (ii) relevant stimuli can tonically and selectively activate hippocampal pyramidal
cells as long as theta activity is present.'
acknowledgement: We thank M. Recce for continuous support, A. Berthoz for advice,
K. Moorefor his participation in the early stages of the experiments, J. Lee for helpand
C. King for his comments on the manuscript. This work was supportedby NIH (NS34994,
MH54671), the Human Frontier Science Program (H.H.),the Hungarian Eo ̈tvo ̈s State
Fellowship (A.C.) and the Soros Foundation (A.C.)
article_processing_charge: No
article_type: original
author:
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. Sustained activation of hippocampal
pyramidal cells by ‘space clamping’’ in a running wheel.’ European Journal
of Neuroscience. 1999;11(1):344-352. doi:10.1046/j.1460-9568.1999.00446.x
apa: Czurkó, A., Hirase, H., Csicsvari, J. L., & Buzsáki, G. (1999). Sustained
activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel.’
European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00446.x
chicago: Czurkó, András, Hajima Hirase, Jozsef L Csicsvari, and György Buzsáki.
“Sustained Activation of Hippocampal Pyramidal Cells by ‘space Clamping’’ in a
Running Wheel.’” European Journal of Neuroscience. Wiley-Blackwell, 1999.
https://doi.org/10.1046/j.1460-9568.1999.00446.x.
ieee: A. Czurkó, H. Hirase, J. L. Csicsvari, and G. Buzsáki, “Sustained activation
of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel,’” European
Journal of Neuroscience, vol. 11, no. 1. Wiley-Blackwell, pp. 344–352, 1999.
ista: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. 1999. Sustained activation of
hippocampal pyramidal cells by ‘space clamping’’ in a running wheel’. European
Journal of Neuroscience. 11(1), 344–352.
mla: Czurkó, András, et al. “Sustained Activation of Hippocampal Pyramidal Cells
by ‘space Clamping’’ in a Running Wheel.’” European Journal of Neuroscience,
vol. 11, no. 1, Wiley-Blackwell, 1999, pp. 344–52, doi:10.1046/j.1460-9568.1999.00446.x.
short: A. Czurkó, H. Hirase, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
11 (1999) 344–352.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:09:08Z
day: '01'
doi: 10.1046/j.1460-9568.1999.00446.x
extern: '1'
external_id:
pmid:
- '9987037'
intvolume: ' 11'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 344 - 352
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2867'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sustained activation of hippocampal pyramidal cells by ‘space clamping' in
a running wheel
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...
---
_id: '3539'
abstract:
- lang: eng
text: In the hippocampus, spatial representation of the environment has been suggested
to be coded by either the firing rate of pyramidal cell assemblies or the relative
timing of the action potentials during the theta EEG cycle. Here, we used a behavioural
`space clamp' method, which involved the confinement of the actively running animal
in a defined position in space (running wheel) to examine how `spatial' and other
inputs affect firing rate and timing of hippocampal CA1 pyramidal cells and interneurons.
Nineteen per cent of the recorded CA1 pyramidal cells were selectively active
while the rat was running in the wheel in a given direction ('wheel' cells). Spatial
rotation of the apparatus showed that selective discharge of pyramidal cells in
the wheel was under the combined influence of distal and apparatus cues. During
steady running, both discharge rate and theta phase were constant. Rotation of
the wheel apparatus resulted in a shift of both firing rate and preferred theta
phase. The discharge frequency of `wheel' cells increased threefold (on average)
with increasing running velocity. In contrast, change in running speed had relatively
little effect on the theta phase-related discharge of `wheel' cells. Our findings
indicate that mechanisms that regulate rate and phase of spikes are overlapping
but not necessarily identical.
acknowledgement: 'We thank M. Recce for his comments on the manuscript. This work
wassupported by NIH (NS34994, MH54671), the Human Frontier ScienceProgram (H.H.),
the EoÈtvoÈs State Fellowship (A.C.) and the Soros Foundation (A.C.) '
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Firing rate and theta-phase coding
by hippocampal pyramidal neurons during ‘space clamping.’ European Journal
of Neuroscience. 1999;11(12):4373-4380. doi:10.1046/j.1460-9568.1999.00853.x
apa: Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999). Firing
rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping.’
European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00853.x
chicago: Hirase, Hajima, András Czurkó, Jozsef L Csicsvari, and György Buzsáki.
“Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal Neurons during ‘Space
Clamping.’” European Journal of Neuroscience. Wiley-Blackwell, 1999. https://doi.org/10.1046/j.1460-9568.1999.00853.x.
ieee: H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rate and theta-phase
coding by hippocampal pyramidal neurons during ‘space clamping,’” European
Journal of Neuroscience, vol. 11, no. 12. Wiley-Blackwell, pp. 4373–4380,
1999.
ista: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Firing rate and theta-phase
coding by hippocampal pyramidal neurons during ‘space clamping’. European Journal
of Neuroscience. 11(12), 4373–4380.
mla: Hirase, Hajima, et al. “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal
Neurons during ‘Space Clamping.’” European Journal of Neuroscience, vol.
11, no. 12, Wiley-Blackwell, 1999, pp. 4373–80, doi:10.1046/j.1460-9568.1999.00853.x.
short: H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
11 (1999) 4373–4380.
date_created: 2018-12-11T12:03:51Z
date_published: 1999-12-01T00:00:00Z
date_updated: 2022-09-06T09:45:36Z
day: '01'
doi: 10.1046/j.1460-9568.1999.00853.x
extern: '1'
external_id:
pmid:
- '10594664 '
intvolume: ' 11'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 4373 - 4380
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2845'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Firing rate and theta-phase coding by hippocampal pyramidal neurons during
‘space clamping’
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...
---
_id: '3515'
abstract:
- lang: eng
text: Oscillations in neuronal networks are assumed to serve various physiological
functions, from coordination of motor patterns to perceptual binding of sensory
information. Here, we describe an ultra-slow oscillation (0.025 Hz) in the hippocampus.
Extracellular and intracellular activity was recorded from the CA1 and subicular
regions in rats of the Wistar and Sprague-Dawley strains. anesthetized with urethane.
in a subgroup of Wistar rats (23%), spontaneous afterdischarges (4.7 +/- 1.6 s)
occurred regularly at 40.8 +/- 15.7 s. The afterdischarge was initiated by a fast
increase of population synchrony (100-250 Hz oscillation; “tonic” phase), followed
by large-amplitude rhythmic waves and associated action potentials at gamma and
beta frequency (15-50 Hz; “clonic” phase). The afterdischarges were bilaterally
synchronous and terminated relatively abruptly without post-ictal depression.
Single-pulse stimulation of the commissural input could trigger afterdischarges,
but only at times when they were about to occur. Commissural stimulation evoked
inhibitory postsynaptic potentials in pyramidal cells. However, when the stimulus
triggered an afterdischarge, the inhibitory postsynaptic potential was absent
and the cells remained depolarized during most of the afterdischarge. Afterdischarges
were not observed in the Sprague-Dawley rats. Long-term analysis of interneuronal
activity in intact, drug-free rats also revealed periodic excitability changes
in the hippocampal network at 0.025 Hz. These findings indicate the presence of
an ultra-slow oscillation in the hippocampal formation. The ultra-slow clock induced
afterdischarges in susceptible animals. We hypothesize that a transient failure
of GABAergic inhibition in a subset of Wistar rats is responsible for the emergence
of epileptiform patterns. (C) 1999 IBRO. Published by Elsevier Science Ltd.
acknowledgement: This work was supported by the Academy of Finland (32391) and the
NIH (NS34994, MH54671).
article_processing_charge: No
article_type: original
author:
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: Nina
full_name: Nurminen, Nina
last_name: Nurminen
- first_name: Riitta
full_name: Miettinen, Riitta
last_name: Miettinen
- first_name: Jouni
full_name: Sirviö, Jouni
last_name: Sirviö
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Penttonen M, Nurminen N, Miettinen R, et al. Ultra-slow oscillation (0.025
Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience.
1999;94(3):735-743. doi:10.1016/S0306-4522(99)00367-X
apa: Penttonen, M., Nurminen, N., Miettinen, R., Sirviö, J., Henze, D., Csicsvari,
J. L., & Buzsáki, G. (1999). Ultra-slow oscillation (0.025 Hz) triggers hippocampal
afterdischarges in Wistar rats. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(99)00367-X
chicago: Penttonen, Markku, Nina Nurminen, Riitta Miettinen, Jouni Sirviö, Darrell
Henze, Jozsef L Csicsvari, and György Buzsáki. “Ultra-Slow Oscillation (0.025
Hz) Triggers Hippocampal Afterdischarges in Wistar Rats.” Neuroscience.
Elsevier, 1999. https://doi.org/10.1016/S0306-4522(99)00367-X.
ieee: M. Penttonen et al., “Ultra-slow oscillation (0.025 Hz) triggers hippocampal
afterdischarges in Wistar rats,” Neuroscience, vol. 94, no. 3. Elsevier,
pp. 735–743, 1999.
ista: Penttonen M, Nurminen N, Miettinen R, Sirviö J, Henze D, Csicsvari JL, Buzsáki
G. 1999. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges
in Wistar rats. Neuroscience. 94(3), 735–743.
mla: Penttonen, Markku, et al. “Ultra-Slow Oscillation (0.025 Hz) Triggers Hippocampal
Afterdischarges in Wistar Rats.” Neuroscience, vol. 94, no. 3, Elsevier,
1999, pp. 735–43, doi:10.1016/S0306-4522(99)00367-X.
short: M. Penttonen, N. Nurminen, R. Miettinen, J. Sirviö, D. Henze, J.L. Csicsvari,
G. Buzsáki, Neuroscience 94 (1999) 735–743.
date_created: 2018-12-11T12:03:44Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-07T13:16:01Z
day: '01'
doi: 10.1016/S0306-4522(99)00367-X
extern: '1'
external_id:
pmid:
- '10579564'
intvolume: ' 94'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 735 - 743
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '2870'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar
rats
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 94
year: '1999'
...
---
_id: '3521'
abstract:
- lang: eng
text: Spike transmission probability between pyramidal cells and interneurons in
the CA1 pyramidal layer was investigated in the behaving rat by the simultaneous
recording of neuronal ensembles. Population synchrony was strongest during sharp
wave (SPW) bursts. However, the increase was three times larger for pyramidal
cells than for interneurons. The contribution of single pyramidal cells to the
discharge of interneurons was often large (up to 0.6 probability), as assessed
by the presence of significant (<3 ms) peaks in the cross-correlogram. Complex-spike
bursts were more effective than single spikes. Single cell contribution was higher
between SPW bursts than during SPWs or theta activity. Hence, single pyramidal
cells can reliably discharge interneurons, and the probability of spike transmission
is behavior dependent.
acknowledgement: We thank C. King, R. Miles, M. Recce, and the anonymous reviewers
for their constructive comments on the manuscript. This work was supported by the
National Institutes of Health (NS34994, MH54671 1P41RR09754), the Human Frontier
Science Program, and the Whitehall Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: 'Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. Reliability and state dependence
of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach
in the behaving rat. Neuron. 1998;21(1):179-189. doi:10.1016/S0896-6273(00)80525-5'
apa: 'Csicsvari, J. L., Hirase, H., Czurkó, A., & Buzsáki, G. (1998). Reliability
and state dependence of pyramidal cell-interneuron synapses in the hippocampus:
an ensemble approach in the behaving rat. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)80525-5'
chicago: 'Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, and György Buzsáki.
“Reliability and State Dependence of Pyramidal Cell-Interneuron Synapses in the
Hippocampus: An Ensemble Approach in the Behaving Rat.” Neuron. Elsevier,
1998. https://doi.org/10.1016/S0896-6273(00)80525-5.'
ieee: 'J. L. Csicsvari, H. Hirase, A. Czurkó, and G. Buzsáki, “Reliability and state
dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble
approach in the behaving rat,” Neuron, vol. 21, no. 1. Elsevier, pp. 179–189,
1998.'
ista: 'Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. 1998. Reliability and state
dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble
approach in the behaving rat. Neuron. 21(1), 179–189.'
mla: 'Csicsvari, Jozsef L., et al. “Reliability and State Dependence of Pyramidal
Cell-Interneuron Synapses in the Hippocampus: An Ensemble Approach in the Behaving
Rat.” Neuron, vol. 21, no. 1, Elsevier, 1998, pp. 179–89, doi:10.1016/S0896-6273(00)80525-5.'
short: J.L. Csicsvari, H. Hirase, A. Czurkó, G. Buzsáki, Neuron 21 (1998) 179–189.
date_created: 2018-12-11T12:03:46Z
date_published: 1998-07-01T00:00:00Z
date_updated: 2022-08-29T14:03:55Z
day: '01'
doi: 10.1016/S0896-6273(00)80525-5
extern: '1'
external_id:
pmid:
- '9697862 '
intvolume: ' 21'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 179 - 189
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2865'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Reliability and state dependence of pyramidal cell-interneuron synapses in
the hippocampus: an ensemble approach in the behaving rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '1998'
...
---
_id: '3535'
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: 'Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Hippocampal pyramidal neutrons
“space-clamped” in a running wheel task: Place cells or path integrators? European
Journal of Neuroscience. 1998;10(Suppl. 10):9932-9932.'
apa: 'Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1998). Hippocampal
pyramidal neutrons “space-clamped” in a running wheel task: Place cells or path
integrators? European Journal of Neuroscience. Wiley-Blackwell.'
chicago: 'Hirase, Hajima, András Czurkó, Jozsef L Csicsvari, and György Buzsáki.
“Hippocampal Pyramidal Neutrons ‘Space-Clamped’ in a Running Wheel Task: Place
Cells or Path Integrators?” European Journal of Neuroscience. Wiley-Blackwell,
1998.'
ieee: 'H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Hippocampal pyramidal
neutrons ‘space-clamped’ in a running wheel task: Place cells or path integrators?,”
European Journal of Neuroscience, vol. 10, no. Suppl. 10. Wiley-Blackwell,
pp. 9932–9932, 1998.'
ista: 'Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1998. Hippocampal pyramidal
neutrons “space-clamped” in a running wheel task: Place cells or path integrators?
European Journal of Neuroscience. 10(Suppl. 10), 9932–9932.'
mla: 'Hirase, Hajima, et al. “Hippocampal Pyramidal Neutrons ‘Space-Clamped’ in
a Running Wheel Task: Place Cells or Path Integrators?” European Journal of
Neuroscience, vol. 10, no. Suppl. 10, Wiley-Blackwell, 1998, pp. 9932–9932.'
short: H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
10 (1998) 9932–9932.
date_created: 2018-12-11T12:03:50Z
date_published: 1998-01-01T00:00:00Z
date_updated: 2021-01-12T07:44:08Z
day: '01'
extern: 1
intvolume: ' 10'
issue: Suppl. 10
month: '01'
page: 9932 - 9932
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2850'
quality_controlled: 0
status: public
title: 'Hippocampal pyramidal neutrons “space-clamped” in a running wheel task: Place
cells or path integrators?'
type: journal_article
volume: 10
year: '1998'
...
---
_id: '3525'
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. Persistence and temporal
compression of spike sequences during fast field oscillation in the hippocampus.
European Journal of Neuroscience. 1998;10(Suppl. 10):9409-9409.
apa: Nádasdy, Z., Csicsvari, J. L., Hirase, H., Czurkó, A., & Buzsáki, G. (1998).
Persistence and temporal compression of spike sequences during fast field oscillation
in the hippocampus. European Journal of Neuroscience. Wiley-Blackwell.
chicago: Nádasdy, Zoltán, Jozsef L Csicsvari, Hajima Hirase, András Czurkó, and
György Buzsáki. “Persistence and Temporal Compression of Spike Sequences during
Fast Field Oscillation in the Hippocampus.” European Journal of Neuroscience.
Wiley-Blackwell, 1998.
ieee: Z. Nádasdy, J. L. Csicsvari, H. Hirase, A. Czurkó, and G. Buzsáki, “Persistence
and temporal compression of spike sequences during fast field oscillation in the
hippocampus,” European Journal of Neuroscience, vol. 10, no. Suppl. 10.
Wiley-Blackwell, pp. 9409–9409, 1998.
ista: Nádasdy Z, Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. 1998. Persistence
and temporal compression of spike sequences during fast field oscillation in the
hippocampus. European Journal of Neuroscience. 10(Suppl. 10), 9409–9409.
mla: Nádasdy, Zoltán, et al. “Persistence and Temporal Compression of Spike Sequences
during Fast Field Oscillation in the Hippocampus.” European Journal of Neuroscience,
vol. 10, no. Suppl. 10, Wiley-Blackwell, 1998, pp. 9409–9409.
short: Z. Nádasdy, J.L. Csicsvari, H. Hirase, A. Czurkó, G. Buzsáki, European Journal
of Neuroscience 10 (1998) 9409–9409.
date_created: 2018-12-11T12:03:47Z
date_published: 1998-06-01T00:00:00Z
date_updated: 2021-01-12T07:44:04Z
day: '01'
extern: 1
intvolume: ' 10'
issue: Suppl. 10
month: '06'
page: 9409 - 9409
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2861'
quality_controlled: 0
status: public
title: Persistence and temporal compression of spike sequences during fast field oscillation
in the hippocampus
type: journal_article
volume: 10
year: '1998'
...
---
_id: '3527'
author:
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Czurkó A, Hirase H, Buzsáki G. Monosynaptic interactions between
CA1 Pyramidal cells and interneuron in the behaving rat. European Journal of
Neuroscience. 1998;10(Suppl. 10):2553-2553.
apa: Csicsvari, J. L., Czurkó, A., Hirase, H., & Buzsáki, G. (1998). Monosynaptic
interactions between CA1 Pyramidal cells and interneuron in the behaving rat.
European Journal of Neuroscience. Wiley-Blackwell.
chicago: Csicsvari, Jozsef L, András Czurkó, Hajima Hirase, and György Buzsáki.
“Monosynaptic Interactions between CA1 Pyramidal Cells and Interneuron in the
Behaving Rat.” European Journal of Neuroscience. Wiley-Blackwell, 1998.
ieee: J. L. Csicsvari, A. Czurkó, H. Hirase, and G. Buzsáki, “Monosynaptic interactions
between CA1 Pyramidal cells and interneuron in the behaving rat,” European
Journal of Neuroscience, vol. 10, no. Suppl. 10. Wiley-Blackwell, pp. 2553–2553,
1998.
ista: Csicsvari JL, Czurkó A, Hirase H, Buzsáki G. 1998. Monosynaptic interactions
between CA1 Pyramidal cells and interneuron in the behaving rat. European Journal
of Neuroscience. 10(Suppl. 10), 2553–2553.
mla: Csicsvari, Jozsef L., et al. “Monosynaptic Interactions between CA1 Pyramidal
Cells and Interneuron in the Behaving Rat.” European Journal of Neuroscience,
vol. 10, no. Suppl. 10, Wiley-Blackwell, 1998, pp. 2553–2553.
short: J.L. Csicsvari, A. Czurkó, H. Hirase, G. Buzsáki, European Journal of Neuroscience
10 (1998) 2553–2553.
date_created: 2018-12-11T12:03:48Z
date_published: 1998-06-01T00:00:00Z
date_updated: 2021-01-12T07:44:05Z
day: '01'
extern: 1
intvolume: ' 10'
issue: Suppl. 10
month: '06'
page: 2553 - 2553
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2858'
quality_controlled: 0
status: public
title: Monosynaptic interactions between CA1 Pyramidal cells and interneuron in the
behaving rat
type: journal_article
volume: 10
year: '1998'
...
---
_id: '3541'
abstract:
- lang: eng
text: 'The contribution of the various hippocampal regions to the maintenance of
epileptic activity, induced by stimulation of the perforant path or commissural
system, was examined in the awake rat. Combination of multiple-site recordings
with silicon probes, current source density analysis and unit recordings allowed
for a high spatial resolution of the field events. Following perforant path stimulation,
seizures began in the dentate gyrus, followed by events in the CA3-CA1 regions.
After commissural stimulation, rhythmic bursts in the CA3-CA1 circuitry preceded
the activation of the dentate gyrus. Correlation of events in the different subregions
indicated that the sustained rhythmic afterdischarge (2-6 Hz) could not be explained
by a cycle-by-cycle excitation of principal cell populations in the hippocampal-entorhinal
loop. The primary afterdischarge always terminated in the CA1 region, followed
by the dentate gyrus, CA3 region and the entorhinal cortex. The duration and pattern
of the hippocampal afterdischarge was essentially unaffected by removal of the
entorhinal cortex. The emergence of large population spike bursts coincided with
a decreased discharge of interneurons in both CAI and hilar regions. The majority
of hilar interneurons displayed a strong amplitude decrement prior to the onset
of population spike phase of the afterdischarge. These findings suggest that (i)
afterdischarges can independently arise in the CA3-CA1 and entorhinal-dentate
gyrus circuitries, (ii) reverberation of excitation in the hippocampal-entorhinal
loop is not critical for the maintenance of afterdischarges and (iii) decreased
activity of the interneuronal network may release population bursting of principal
cells. '
acknowledgement: We thank K. Wise and J. Hetke for providing us the silicon probes,
J. J. Chrobak, S. L-W. Leung, G. G. Somjen and R. D. Traub for their comments on
the manuscript. This work was supported by NINDS (NS34994; 1P41RR09754; NS33310)
and the Whitehall Foundation. M. Penttonen was a visiting scholar at Rutgers University,
supported by the Finnish Academy of Sciences and the A. I. Virtanen Institute.
article_processing_charge: No
article_type: original
author:
- first_name: Anatol
full_name: Bragin, Anatol
last_name: Bragin
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: 'Bragin A, Csicsvari JL, Penttonen M, Buzsáki G. Epileptic afterdischarge in
the hippocampal-entorhinal system: Current source density and unit studies. Neuroscience.
1997;76(4):1187-1203. doi:10.1016/S0306-4522(96)00446-0'
apa: 'Bragin, A., Csicsvari, J. L., Penttonen, M., & Buzsáki, G. (1997). Epileptic
afterdischarge in the hippocampal-entorhinal system: Current source density and
unit studies. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(96)00446-0'
chicago: 'Bragin, Anatol, Jozsef L Csicsvari, Markku Penttonen, and György Buzsáki.
“Epileptic Afterdischarge in the Hippocampal-Entorhinal System: Current Source
Density and Unit Studies.” Neuroscience. Elsevier, 1997. https://doi.org/10.1016/S0306-4522(96)00446-0.'
ieee: 'A. Bragin, J. L. Csicsvari, M. Penttonen, and G. Buzsáki, “Epileptic afterdischarge
in the hippocampal-entorhinal system: Current source density and unit studies,”
Neuroscience, vol. 76, no. 4. Elsevier, pp. 1187–1203, 1997.'
ista: 'Bragin A, Csicsvari JL, Penttonen M, Buzsáki G. 1997. Epileptic afterdischarge
in the hippocampal-entorhinal system: Current source density and unit studies.
Neuroscience. 76(4), 1187–1203.'
mla: 'Bragin, Anatol, et al. “Epileptic Afterdischarge in the Hippocampal-Entorhinal
System: Current Source Density and Unit Studies.” Neuroscience, vol. 76,
no. 4, Elsevier, 1997, pp. 1187–203, doi:10.1016/S0306-4522(96)00446-0.'
short: A. Bragin, J.L. Csicsvari, M. Penttonen, G. Buzsáki, Neuroscience 76 (1997)
1187–1203.
date_created: 2018-12-11T12:03:52Z
date_published: 1997-01-15T00:00:00Z
date_updated: 2022-08-19T11:53:06Z
day: '15'
doi: 10.1016/S0306-4522(96)00446-0
extern: '1'
external_id:
pmid:
- '9027878'
intvolume: ' 76'
issue: '4'
language:
- iso: eng
month: '01'
oa_version: None
page: 1187 - 1203
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '2844'
quality_controlled: '1'
status: public
title: 'Epileptic afterdischarge in the hippocampal-entorhinal system: Current source
density and unit studies'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 76
year: '1997'
...
---
_id: '3446'
abstract:
- lang: eng
text: An effective character recognition procedure implemented on a new type of
hardware system and using a new architecture called CNND is proposed. This CNND
contains one or more analog cellular neural networks (CNNs) and some digital logic,
combining the advantages of the fast analog CNN signal processing and the fast
and easy decision capability of digital logic. It is shown that the CNND system
can be used for recognition of multifont printed or handwritten characters and
could recognize 100,000 char/s with a recognition rate of more than 95%. The more
advantage of the system over competing types is that there is not an extra feature
extraction procedure implemented in slow hardware
article_processing_charge: No
article_type: original
author:
- first_name: Tamas
full_name: Sziranyi, Tamas
last_name: Sziranyi
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: 'Sziranyi T, Csicsvari JL. High-speed character recognition using a dual cellular
neural network architecture (CNND). IEEE Transactions on Circuits and Systems
II: Analog and Digital Signal Processing. 1993;40(3):223-231. doi:10.1109/82.222823'
apa: 'Sziranyi, T., & Csicsvari, J. L. (1993). High-speed character recognition
using a dual cellular neural network architecture (CNND). IEEE Transactions
on Circuits and Systems II: Analog and Digital Signal Processing. IEEE. https://doi.org/10.1109/82.222823'
chicago: 'Sziranyi, Tamas, and Jozsef L Csicsvari. “High-Speed Character Recognition
Using a Dual Cellular Neural Network Architecture (CNND).” IEEE Transactions
on Circuits and Systems II: Analog and Digital Signal Processing. IEEE, 1993.
https://doi.org/10.1109/82.222823.'
ieee: 'T. Sziranyi and J. L. Csicsvari, “High-speed character recognition using
a dual cellular neural network architecture (CNND),” IEEE Transactions on Circuits
and Systems II: Analog and Digital Signal Processing, vol. 40, no. 3. IEEE,
pp. 223–231, 1993.'
ista: 'Sziranyi T, Csicsvari JL. 1993. High-speed character recognition using a
dual cellular neural network architecture (CNND). IEEE Transactions on Circuits
and Systems II: Analog and Digital Signal Processing. 40(3), 223–231.'
mla: 'Sziranyi, Tamas, and Jozsef L. Csicsvari. “High-Speed Character Recognition
Using a Dual Cellular Neural Network Architecture (CNND).” IEEE Transactions
on Circuits and Systems II: Analog and Digital Signal Processing, vol. 40,
no. 3, IEEE, 1993, pp. 223–31, doi:10.1109/82.222823.'
short: 'T. Sziranyi, J.L. Csicsvari, IEEE Transactions on Circuits and Systems II:
Analog and Digital Signal Processing 40 (1993) 223–231.'
date_created: 2018-12-11T12:03:22Z
date_published: 1993-03-01T00:00:00Z
date_updated: 2022-03-30T14:44:44Z
day: '01'
doi: 10.1109/82.222823
extern: '1'
intvolume: ' 40'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/222823
month: '03'
oa_version: None
page: 223 - 231
publication: 'IEEE Transactions on Circuits and Systems II: Analog and Digital Signal
Processing'
publication_identifier:
issn:
- 1057-7130
publication_status: published
publisher: IEEE
publist_id: '2941'
quality_controlled: '1'
scopus_import: '1'
status: public
title: High-speed character recognition using a dual cellular neural network architecture
(CNND)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 40
year: '1993'
...