[{"day":"26","article_processing_charge":"Yes","has_accepted_license":"1","scopus_import":"1","date_published":"2023-09-26T00:00:00Z","article_type":"original","publication":"Cell Reports","citation":{"ista":"Nardin M, Käfer K, Stella F, Csicsvari JL. 2023. Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions. Cell Reports. 42(9), 113015.","ieee":"M. Nardin, K. Käfer, F. Stella, and J. L. Csicsvari, “Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions,” Cell Reports, vol. 42, no. 9. Elsevier, 2023.","apa":"Nardin, M., Käfer, K., Stella, F., & Csicsvari, J. L. (2023). Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2023.113015","ama":"Nardin M, Käfer K, Stella F, Csicsvari JL. Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions. Cell Reports. 2023;42(9). doi:10.1016/j.celrep.2023.113015","chicago":"Nardin, Michele, Karola Käfer, Federico Stella, and Jozsef L Csicsvari. “Theta Oscillations as a Substrate for Medial Prefrontal-Hippocampal Assembly Interactions.” Cell Reports. Elsevier, 2023. https://doi.org/10.1016/j.celrep.2023.113015.","mla":"Nardin, Michele, et al. “Theta Oscillations as a Substrate for Medial Prefrontal-Hippocampal Assembly Interactions.” Cell Reports, vol. 42, no. 9, 113015, Elsevier, 2023, doi:10.1016/j.celrep.2023.113015.","short":"M. Nardin, K. Käfer, F. Stella, J.L. Csicsvari, Cell Reports 42 (2023)."},"abstract":[{"text":"The execution of cognitive functions requires coordinated circuit activity across different brain areas that involves the associated firing of neuronal assemblies. Here, we tested the circuit mechanism behind assembly interactions between the hippocampus and the medial prefrontal cortex (mPFC) of adult rats by recording neuronal populations during a rule-switching task. We identified functionally coupled CA1-mPFC cells that synchronized their activity beyond that expected from common spatial coding or oscillatory firing. When such cell pairs fired together, the mPFC cell strongly phase locked to CA1 theta oscillations and maintained consistent theta firing phases, independent of the theta timing of their CA1 counterpart. These functionally connected CA1-mPFC cells formed interconnected assemblies. While firing together with their CA1 assembly partners, mPFC cells fired along specific theta sequences. Our results suggest that upregulated theta oscillatory firing of mPFC cells can signal transient interactions with specific CA1 assemblies, thus enabling distributed computations.","lang":"eng"}],"issue":"9","type":"journal_article","oa_version":"Published Version","file":[{"file_name":"2023_CellPress_Nardin.pdf","access_level":"open_access","creator":"dernst","file_size":4879455,"content_type":"application/pdf","file_id":"14337","relation":"main_file","date_updated":"2023-09-15T07:12:46Z","date_created":"2023-09-15T07:12:46Z","success":1,"checksum":"ca77a304fb813c292550b8604b0fb41d"}],"title":"Theta oscillations as a substrate for medial prefrontal-hippocampal assembly interactions","ddc":["570"],"status":"public","intvolume":" 42","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"14314","month":"09","publication_identifier":{"eissn":["2211-1247"]},"language":[{"iso":"eng"}],"doi":"10.1016/j.celrep.2023.113015","quality_controlled":"1","project":[{"call_identifier":"FP7","name":"Inter-and intracellular signalling in schizophrenia","_id":"257BBB4C-B435-11E9-9278-68D0E5697425","grant_number":"607616"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"pmid":["37632747"]},"license":"https://creativecommons.org/licenses/by/4.0/","file_date_updated":"2023-09-15T07:12:46Z","ec_funded":1,"article_number":"113015","date_updated":"2023-09-15T07:14:12Z","date_created":"2023-09-10T22:01:11Z","volume":42,"author":[{"id":"30BD0376-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8849-6570","first_name":"Michele","last_name":"Nardin","full_name":"Nardin, Michele"},{"full_name":"Käfer, Karola","id":"2DAA49AA-F248-11E8-B48F-1D18A9856A87","last_name":"Käfer","first_name":"Karola"},{"id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9439-3148","first_name":"Federico","last_name":"Stella","full_name":"Stella, Federico"},{"full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036"}],"publication_status":"published","department":[{"_id":"JoCs"}],"publisher":"Elsevier","year":"2023","acknowledgement":"We thank A. Cumpelik, H. Chiossi, and L. Bollman for comments on an earlier version of this manuscript. This work was funded by EU-FP7 MC-ITN IN-SENS (grant 607616).","pmid":1},{"file_date_updated":"2020-07-14T12:47:40Z","year":"2020","pmid":1,"publication_status":"published","publisher":"Wiley","department":[{"_id":"JoCs"}],"author":[{"orcid":"0000-0001-9439-3148","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","last_name":"Stella","first_name":"Federico","full_name":"Stella, Federico"},{"last_name":"Urdapilleta","first_name":"Eugenio","full_name":"Urdapilleta, Eugenio"},{"first_name":"Yifan","last_name":"Luo","full_name":"Luo, Yifan"},{"full_name":"Treves, Alessandro","last_name":"Treves","first_name":"Alessandro"}],"date_created":"2019-08-11T21:59:24Z","date_updated":"2023-08-17T13:53:14Z","volume":30,"month":"04","publication_identifier":{"eissn":["10981063"],"issn":["10509631"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"pmid":["31339190"],"isi":["000477299600001"]},"isi":1,"quality_controlled":"1","doi":"10.1002/hipo.23144","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"text":"Nearby grid cells have been observed to express a remarkable degree of long-rangeorder, which is often idealized as extending potentially to infinity. Yet their strict peri-odic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Are the symmetrical, coherent grid maps inferred in the lab relevant to chart their way in their natural habitat? We consider spheres as simple models of curved environments and waiting for the appropriate experiments to be performed, we use our adaptation model to predict what grid maps would emerge in a network with the same type of recurrent connections, which on the plane produce coherence among the units. We find that on the sphere such connections distort the maps that single grid units would express on their own, and aggregate them into clusters. When remapping to a different spherical environment, units in each cluster maintain only partial coherence, similar to what is observed in disordered materials, such as spin glasses.","lang":"eng"}],"issue":"4","_id":"6796","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Partial coherence and frustration in self-organizing spherical grids","status":"public","ddc":["570"],"intvolume":" 30","oa_version":"Published Version","file":[{"date_created":"2019-08-12T07:53:33Z","date_updated":"2020-07-14T12:47:40Z","checksum":"7b54d22bfbfc0d1188a9ea24d985bfb2","relation":"main_file","file_id":"6800","content_type":"application/pdf","file_size":2370658,"creator":"dernst","file_name":"2019_Hippocampus_Stella.pdf","access_level":"open_access"}],"scopus_import":"1","day":"01","has_accepted_license":"1","article_processing_charge":"No","publication":"Hippocampus","citation":{"chicago":"Stella, Federico, Eugenio Urdapilleta, Yifan Luo, and Alessandro Treves. “Partial Coherence and Frustration in Self-Organizing Spherical Grids.” Hippocampus. Wiley, 2020. https://doi.org/10.1002/hipo.23144.","mla":"Stella, Federico, et al. “Partial Coherence and Frustration in Self-Organizing Spherical Grids.” Hippocampus, vol. 30, no. 4, Wiley, 2020, pp. 302–13, doi:10.1002/hipo.23144.","short":"F. Stella, E. Urdapilleta, Y. Luo, A. Treves, Hippocampus 30 (2020) 302–313.","ista":"Stella F, Urdapilleta E, Luo Y, Treves A. 2020. Partial coherence and frustration in self-organizing spherical grids. Hippocampus. 30(4), 302–313.","ieee":"F. Stella, E. Urdapilleta, Y. Luo, and A. Treves, “Partial coherence and frustration in self-organizing spherical grids,” Hippocampus, vol. 30, no. 4. Wiley, pp. 302–313, 2020.","apa":"Stella, F., Urdapilleta, E., Luo, Y., & Treves, A. (2020). Partial coherence and frustration in self-organizing spherical grids. Hippocampus. Wiley. https://doi.org/10.1002/hipo.23144","ama":"Stella F, Urdapilleta E, Luo Y, Treves A. Partial coherence and frustration in self-organizing spherical grids. Hippocampus. 2020;30(4):302-313. doi:10.1002/hipo.23144"},"article_type":"original","page":"302-313","date_published":"2020-04-01T00:00:00Z"},{"month":"04","quality_controlled":"1","isi":1,"project":[{"_id":"257A4776-B435-11E9-9278-68D0E5697425","grant_number":"281511","name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","call_identifier":"FP7"},{"grant_number":"I03713","_id":"2654F984-B435-11E9-9278-68D0E5697425","name":"Interneuro Plasticity During Spatial Learning","call_identifier":"FWF"}],"oa":1,"external_id":{"pmid":["30819547"],"isi":["000465169700017"]},"main_file_link":[{"url":"https://doi.org/10.1016/j.neuron.2019.01.052","open_access":"1"}],"language":[{"iso":"eng"}],"doi":"10.1016/j.neuron.2019.01.052","ec_funded":1,"publication_status":"published","publisher":"Elsevier","department":[{"_id":"JoCs"}],"year":"2019","pmid":1,"date_updated":"2023-08-25T10:13:07Z","date_created":"2019-04-17T08:28:59Z","volume":102,"author":[{"orcid":"0000-0001-9439-3148","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","last_name":"Stella","first_name":"Federico","full_name":"Stella, Federico"},{"first_name":"Peter","last_name":"Baracskay","id":"361CC00E-F248-11E8-B48F-1D18A9856A87","full_name":"Baracskay, Peter"},{"id":"426376DC-F248-11E8-B48F-1D18A9856A87","first_name":"Joseph","last_name":"O'Neill","full_name":"O'Neill, Joseph"},{"full_name":"Csicsvari, Jozsef L","last_name":"Csicsvari","first_name":"Jozsef L","orcid":"0000-0002-5193-4036","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"}],"related_material":{"link":[{"url":"https://ist.ac.at/en/news/memories-of-movement-are-replayed-randomly-during-sleep/","relation":"press_release","description":"News on IST Homepage"}]},"scopus_import":"1","day":"17","article_processing_charge":"No","article_type":"original","page":"450-461","publication":"Neuron","citation":{"mla":"Stella, Federico, et al. “Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.” Neuron, vol. 102, Elsevier, 2019, pp. 450–61, doi:10.1016/j.neuron.2019.01.052.","short":"F. Stella, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 102 (2019) 450–461.","chicago":"Stella, Federico, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari. “Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.01.052.","ama":"Stella F, Baracskay P, O’Neill J, Csicsvari JL. Hippocampal reactivation of random trajectories resembling Brownian diffusion. Neuron. 2019;102:450-461. doi:10.1016/j.neuron.2019.01.052","ista":"Stella F, Baracskay P, O’Neill J, Csicsvari JL. 2019. Hippocampal reactivation of random trajectories resembling Brownian diffusion. Neuron. 102, 450–461.","ieee":"F. Stella, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Hippocampal reactivation of random trajectories resembling Brownian diffusion,” Neuron, vol. 102. Elsevier, pp. 450–461, 2019.","apa":"Stella, F., Baracskay, P., O’Neill, J., & Csicsvari, J. L. (2019). Hippocampal reactivation of random trajectories resembling Brownian diffusion. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2019.01.052"},"date_published":"2019-04-17T00:00:00Z","type":"journal_article","abstract":[{"text":"Hippocampal activity patterns representing movement trajectories are reactivated in immobility and sleep periods, a process associated with memory recall, consolidation, and decision making. It is thought that only fixed, behaviorally relevant patterns can be reactivated, which are stored across hippocampal synaptic connections. To test whether some generalized rules govern reactivation, we examined trajectory reactivation following non-stereotypical exploration of familiar open-field environments. We found that random trajectories of varying lengths and timescales were reactivated, resembling that of Brownian motion of particles. The animals’ behavioral trajectory did not follow Brownian diffusion demonstrating that the exact behavioral experience is not reactivated. Therefore, hippocampal circuits are able to generate random trajectories of any recently active map by following diffusion dynamics. This ability of hippocampal circuits to generate representations of all behavioral outcome combinations, experienced or not, may underlie a wide variety of hippocampal-dependent cognitive functions such as learning, generalization, and planning.","lang":"eng"}],"title":"Hippocampal reactivation of random trajectories resembling Brownian diffusion","status":"public","intvolume":" 102","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6338","oa_version":"Published Version"},{"doi":"10.1126/science.aav4837","language":[{"iso":"eng"}],"external_id":{"isi":["000462738000034"]},"oa":1,"project":[{"grant_number":"281511","_id":"257A4776-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex"},{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"}],"isi":1,"quality_controlled":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"month":"03","related_material":{"record":[{"id":"6062","relation":"popular_science","status":"public"},{"relation":"dissertation_contains","status":"public","id":"11932"}],"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/grid-cells-create-treasure-map-in-rat-brain/"}]},"author":[{"full_name":"Boccara, Charlotte N.","id":"3FC06552-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7237-5109","first_name":"Charlotte N.","last_name":"Boccara"},{"full_name":"Nardin, Michele","first_name":"Michele","last_name":"Nardin","id":"30BD0376-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8849-6570"},{"first_name":"Federico","last_name":"Stella","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9439-3148","full_name":"Stella, Federico"},{"last_name":"O'Neill","first_name":"Joseph","id":"426376DC-F248-11E8-B48F-1D18A9856A87","full_name":"O'Neill, Joseph"},{"last_name":"Csicsvari","first_name":"Jozsef L","orcid":"0000-0002-5193-4036","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","full_name":"Csicsvari, Jozsef L"}],"volume":363,"date_created":"2019-04-04T08:39:30Z","date_updated":"2024-03-28T23:30:16Z","year":"2019","publisher":"American Association for the Advancement of Science","department":[{"_id":"JoCs"}],"publication_status":"published","ec_funded":1,"file_date_updated":"2020-07-14T12:47:23Z","date_published":"2019-03-29T00:00:00Z","citation":{"short":"C.N. Boccara, M. Nardin, F. Stella, J. O’Neill, J.L. Csicsvari, Science 363 (2019) 1443–1447.","mla":"Boccara, Charlotte N., et al. “The Entorhinal Cognitive Map Is Attracted to Goals.” Science, vol. 363, no. 6434, American Association for the Advancement of Science, 2019, pp. 1443–47, doi:10.1126/science.aav4837.","chicago":"Boccara, Charlotte N., Michele Nardin, Federico Stella, Joseph O’Neill, and Jozsef L Csicsvari. “The Entorhinal Cognitive Map Is Attracted to Goals.” Science. American Association for the Advancement of Science, 2019. https://doi.org/10.1126/science.aav4837.","ama":"Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. The entorhinal cognitive map is attracted to goals. Science. 2019;363(6434):1443-1447. doi:10.1126/science.aav4837","apa":"Boccara, C. N., Nardin, M., Stella, F., O’Neill, J., & Csicsvari, J. L. (2019). The entorhinal cognitive map is attracted to goals. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aav4837","ieee":"C. N. Boccara, M. Nardin, F. Stella, J. O’Neill, and J. L. Csicsvari, “The entorhinal cognitive map is attracted to goals,” Science, vol. 363, no. 6434. American Association for the Advancement of Science, pp. 1443–1447, 2019.","ista":"Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. 2019. The entorhinal cognitive map is attracted to goals. Science. 363(6434), 1443–1447."},"publication":"Science","page":"1443-1447","article_type":"original","has_accepted_license":"1","article_processing_charge":"No","day":"29","scopus_import":"1","file":[{"creator":"dernst","file_size":9045923,"content_type":"application/pdf","access_level":"open_access","file_name":"2019_Science_Boccara.pdf","checksum":"5e6b16742cde10a560cfaf2130764da1","date_created":"2020-05-14T09:11:10Z","date_updated":"2020-07-14T12:47:23Z","file_id":"7826","relation":"main_file"}],"oa_version":"Submitted Version","_id":"6194","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","intvolume":" 363","status":"public","ddc":["570"],"title":"The entorhinal cognitive map is attracted to goals","issue":"6434","abstract":[{"lang":"eng","text":"Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric to the hippocampal cognitive map, yet environmental geometrical features have recently been shown to distort the grid structure. Given that the hippocampal role goes beyond space, we tested the influence of nonspatial information on the grid organization. We trained rats to daily learn three new reward locations on a cheeseboard maze while recording from the medial entorhinal cortex and the hippocampal CA1 region. Many grid fields moved toward goal location, leading to long-lasting deformations of the entorhinal map. Therefore, distortions in the grid structure contribute to goal representation during both learning and recall, which demonstrates that grid cells participate in mnemonic coding and do not merely provide a simple metric of space."}],"type":"journal_article"},{"abstract":[{"lang":"eng","text":"Orientation in space is represented in specialized brain circuits. Persistent head direction signals are transmitted from anterior thalamus to the presubiculum, but the identity of the presubicular target neurons, their connectivity and function in local microcircuits are unknown. Here, we examine how thalamic afferents recruit presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic interactions between these cells. Pyramidal neuron activation of Martinotti cells in superficial layers is strongly facilitating such that high-frequency head directional stimulation efficiently unmutes synaptic excitation. Martinotti-cell feedback plays a dual role: precisely timed spikes may not inhibit the firing of in-tune head direction cells, while exerting lateral inhibition. Autonomous attractor dynamics emerge from a modelled network implementing wiring motifs and timing sensitive synaptic interactions in the pyramidal - Martinotti-cell feedback loop. This inhibitory microcircuit is therefore tuned to refine and maintain head direction information in the presubiculum."}],"type":"journal_article","file":[{"content_type":"application/pdf","file_size":2948357,"creator":"system","access_level":"open_access","file_name":"IST-2018-937-v1+1_2017_Stella_Activity_dependent.pdf","checksum":"76d8a2b72a58e56adb410ec37dfa7eee","date_updated":"2020-07-14T12:46:36Z","date_created":"2018-12-12T10:14:31Z","relation":"main_file","file_id":"5083"}],"oa_version":"Published Version","pubrep_id":"937","ddc":["571"],"status":"public","title":"Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum","intvolume":" 8","_id":"514","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"01","has_accepted_license":"1","scopus_import":1,"date_published":"2017-07-01T00:00:00Z","publication":"Nature Communications","citation":{"ama":"Simonnet J, Nassar M, Stella F, et al. Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. 2017;8. doi:10.1038/ncomms16032","ieee":"J. Simonnet et al., “Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum,” Nature Communications, vol. 8. Nature Publishing Group, 2017.","apa":"Simonnet, J., Nassar, M., Stella, F., Cohen, I., Mathon, B., Boccara, C. N., … Fricker, D. (2017). Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms16032","ista":"Simonnet J, Nassar M, Stella F, Cohen I, Mathon B, Boccara CN, Miles R, Fricker D. 2017. Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. 8, 16032.","short":"J. Simonnet, M. Nassar, F. Stella, I. Cohen, B. Mathon, C.N. Boccara, R. Miles, D. Fricker, Nature Communications 8 (2017).","mla":"Simonnet, Jean, et al. “Activity Dependent Feedback Inhibition May Maintain Head Direction Signals in Mouse Presubiculum.” Nature Communications, vol. 8, 16032, Nature Publishing Group, 2017, doi:10.1038/ncomms16032.","chicago":"Simonnet, Jean, Mérie Nassar, Federico Stella, Ivan Cohen, Bertrand Mathon, Charlotte N. Boccara, Richard Miles, and Desdemona Fricker. “Activity Dependent Feedback Inhibition May Maintain Head Direction Signals in Mouse Presubiculum.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms16032."},"file_date_updated":"2020-07-14T12:46:36Z","publist_id":"7305","article_number":"16032","date_created":"2018-12-11T11:46:54Z","date_updated":"2021-01-12T08:01:16Z","volume":8,"author":[{"full_name":"Simonnet, Jean","first_name":"Jean","last_name":"Simonnet"},{"full_name":"Nassar, Mérie","first_name":"Mérie","last_name":"Nassar"},{"full_name":"Stella, Federico","orcid":"0000-0001-9439-3148","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","last_name":"Stella","first_name":"Federico"},{"full_name":"Cohen, Ivan","first_name":"Ivan","last_name":"Cohen"},{"first_name":"Bertrand","last_name":"Mathon","full_name":"Mathon, Bertrand"},{"last_name":"Boccara","first_name":"Charlotte","orcid":"0000-0001-7237-5109","id":"3FC06552-F248-11E8-B48F-1D18A9856A87","full_name":"Boccara, Charlotte"},{"full_name":"Miles, Richard","last_name":"Miles","first_name":"Richard"},{"first_name":"Desdemona","last_name":"Fricker","full_name":"Fricker, Desdemona"}],"publication_status":"published","publisher":"Nature Publishing Group","department":[{"_id":"JoCs"}],"year":"2017","month":"07","publication_identifier":{"issn":["20411723"]},"language":[{"iso":"eng"}],"doi":"10.1038/ncomms16032","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1},{"file_date_updated":"2018-12-12T10:10:22Z","ec_funded":1,"publist_id":"6226","year":"2017","publication_status":"published","publisher":"American Association for the Advancement of Science","department":[{"_id":"JoCs"}],"author":[{"first_name":"Joseph","last_name":"O'Neill","id":"426376DC-F248-11E8-B48F-1D18A9856A87","full_name":"O'Neill, Joseph"},{"full_name":"Boccara, Charlotte","orcid":"0000-0001-7237-5109","id":"3FC06552-F248-11E8-B48F-1D18A9856A87","last_name":"Boccara","first_name":"Charlotte"},{"full_name":"Stella, Federico","orcid":"0000-0001-9439-3148","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","last_name":"Stella","first_name":"Federico"},{"id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","last_name":"Schönenberger","full_name":"Schönenberger, Philipp"},{"orcid":"0000-0002-5193-4036","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","first_name":"Jozsef L","full_name":"Csicsvari, Jozsef L"}],"date_created":"2018-12-11T11:50:19Z","date_updated":"2023-09-20T11:30:35Z","volume":355,"month":"01","publication_identifier":{"issn":["00368075"]},"oa":1,"external_id":{"isi":["000391743700044"]},"isi":1,"quality_controlled":"1","project":[{"_id":"257A4776-B435-11E9-9278-68D0E5697425","grant_number":"281511","call_identifier":"FP7","name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex"}],"doi":"10.1126/science.aag2787","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"lang":"eng","text":"The hippocampus is thought to initiate systems-wide mnemonic processes through the reactivation of previously acquired spatial and episodic memory traces, which can recruit the entorhinal cortex as a first stage of memory redistribution to other brain areas. Hippocampal reactivation occurs during sharp wave-ripples, in which synchronous network firing encodes sequences of places.We investigated the coordination of this replay by recording assembly activity simultaneously in the CA1 region of the hippocampus and superficial layers of the medial entorhinal cortex. We found that entorhinal cell assemblies can replay trajectories independently of the hippocampus and sharp wave-ripples. This suggests that the hippocampus is not the sole initiator of spatial and episodic memory trace reactivation. Memory systems involved in these processes may include nonhierarchical, parallel components."}],"issue":"6321","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"1132","title":"Superficial layers of the medial entorhinal cortex replay independently of the hippocampus","ddc":["571"],"status":"public","intvolume":" 355","pubrep_id":"976","file":[{"file_size":3761201,"content_type":"application/pdf","creator":"system","file_name":"IST-2018-976-v1+1_2017Preprint_ONeill_Superficial_layers.pdf","access_level":"open_access","date_created":"2018-12-12T10:10:22Z","date_updated":"2018-12-12T10:10:22Z","relation":"main_file","file_id":"4809"}],"oa_version":"Submitted Version","scopus_import":"1","day":"13","article_processing_charge":"No","has_accepted_license":"1","publication":"Science","citation":{"mla":"O’Neill, Joseph, et al. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” Science, vol. 355, no. 6321, American Association for the Advancement of Science, 2017, pp. 184–88, doi:10.1126/science.aag2787.","short":"J. O’Neill, C.N. Boccara, F. Stella, P. Schönenberger, J.L. Csicsvari, Science 355 (2017) 184–188.","chicago":"O’Neill, Joseph, Charlotte N. Boccara, Federico Stella, Philipp Schönenberger, and Jozsef L Csicsvari. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” Science. American Association for the Advancement of Science, 2017. https://doi.org/10.1126/science.aag2787.","ama":"O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. 2017;355(6321):184-188. doi:10.1126/science.aag2787","ista":"O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. 2017. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. 355(6321), 184–188.","ieee":"J. O’Neill, C. N. Boccara, F. Stella, P. Schönenberger, and J. L. Csicsvari, “Superficial layers of the medial entorhinal cortex replay independently of the hippocampus,” Science, vol. 355, no. 6321. American Association for the Advancement of Science, pp. 184–188, 2017.","apa":"O’Neill, J., Boccara, C. N., Stella, F., Schönenberger, P., & Csicsvari, J. L. (2017). Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aag2787"},"page":"184 - 188","date_published":"2017-01-13T00:00:00Z"},{"month":"02","quality_controlled":"1","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"doi":"10.1371/journal.pbio.1002384","article_number":"e1002384","publist_id":"5700","file_date_updated":"2020-07-14T12:44:57Z","publisher":"Public Library of Science","department":[{"_id":"JoCs"}],"publication_status":"published","acknowledgement":"We thank Eric Maris, Demian Battaglia, and Rodrigo Quian Quiroga for useful discussions. We are grateful to Fabrizio Manzino and Marco Gigante for construction of the behavioral apparatus, Igor Perkon for developing custom whisker tracking software and to Francesca Pulecchi for animal care and histological processing.","year":"2016","volume":14,"date_created":"2018-12-11T11:52:18Z","date_updated":"2021-01-12T06:51:05Z","author":[{"full_name":"Grion, Natalia","last_name":"Grion","first_name":"Natalia"},{"first_name":"Athena","last_name":"Akrami","full_name":"Akrami, Athena"},{"last_name":"Zuo","first_name":"Yangfang","full_name":"Zuo, Yangfang"},{"full_name":"Stella, Federico","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9439-3148","first_name":"Federico","last_name":"Stella"},{"full_name":"Diamond, Mathew","last_name":"Diamond","first_name":"Mathew"}],"scopus_import":1,"has_accepted_license":"1","day":"18","citation":{"ista":"Grion N, Akrami A, Zuo Y, Stella F, Diamond M. 2016. Coherence between rat sensorimotor system and hippocampus is enhanced during tactile discrimination. PLoS Biology. 14(2), e1002384.","apa":"Grion, N., Akrami, A., Zuo, Y., Stella, F., & Diamond, M. (2016). Coherence between rat sensorimotor system and hippocampus is enhanced during tactile discrimination. PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.1002384","ieee":"N. Grion, A. Akrami, Y. Zuo, F. Stella, and M. Diamond, “Coherence between rat sensorimotor system and hippocampus is enhanced during tactile discrimination,” PLoS Biology, vol. 14, no. 2. Public Library of Science, 2016.","ama":"Grion N, Akrami A, Zuo Y, Stella F, Diamond M. Coherence between rat sensorimotor system and hippocampus is enhanced during tactile discrimination. PLoS Biology. 2016;14(2). doi:10.1371/journal.pbio.1002384","chicago":"Grion, Natalia, Athena Akrami, Yangfang Zuo, Federico Stella, and Mathew Diamond. “Coherence between Rat Sensorimotor System and Hippocampus Is Enhanced during Tactile Discrimination.” PLoS Biology. Public Library of Science, 2016. https://doi.org/10.1371/journal.pbio.1002384.","mla":"Grion, Natalia, et al. “Coherence between Rat Sensorimotor System and Hippocampus Is Enhanced during Tactile Discrimination.” PLoS Biology, vol. 14, no. 2, e1002384, Public Library of Science, 2016, doi:10.1371/journal.pbio.1002384.","short":"N. Grion, A. Akrami, Y. Zuo, F. Stella, M. Diamond, PLoS Biology 14 (2016)."},"publication":"PLoS Biology","date_published":"2016-02-18T00:00:00Z","type":"journal_article","issue":"2","abstract":[{"lang":"eng","text":"Rhythms with time scales of multiple cycles per second permeate the mammalian brain, yet neuroscientists are not certain of their functional roles. One leading idea is that coherent oscillation between two brain regions facilitates the exchange of information between them. In rats, the hippocampus and the vibrissal sensorimotor system both are characterized by rhythmic oscillation in the theta range, 5–12 Hz. Previous work has been divided as to whether the two rhythms are independent or coherent. To resolve this question, we acquired three measures from rats—whisker motion, hippocampal local field potential (LFP), and barrel cortex unit firing—during a whisker-mediated texture discrimination task and during control conditions (not engaged in a whisker-mediated memory task). Compared to control conditions, the theta band of hippocampal LFP showed a marked increase in power as the rats approached and then palpated the texture. Phase synchronization between whisking and hippocampal LFP increased by almost 50% during approach and texture palpation. In addition, a greater proportion of barrel cortex neurons showed firing that was phase-locked to hippocampal theta while rats were engaged in the discrimination task. Consistent with a behavioral consequence of phase synchronization, the rats identified the texture more rapidly and with lower error likelihood on trials in which there was an increase in theta-whisking coherence at the moment of texture palpation. These results suggest that coherence between the whisking rhythm, barrel cortex firing, and hippocampal LFP is augmented selectively during epochs in which the rat collects sensory information and that such coherence enhances the efficiency of integration of stimulus information into memory and decision-making centers."}],"intvolume":" 14","status":"public","title":"Coherence between rat sensorimotor system and hippocampus is enhanced during tactile discrimination","ddc":["570"],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"1487","oa_version":"Published Version","file":[{"checksum":"3a5ce0d4e4e36bd6ceb4be761f85644a","date_created":"2018-12-12T10:15:11Z","date_updated":"2020-07-14T12:44:57Z","file_id":"5129","relation":"main_file","creator":"system","content_type":"application/pdf","file_size":2879899,"access_level":"open_access","file_name":"IST-2016-518-v1+1_journal.pbio.1002384.PDF"}],"pubrep_id":"518"}]