--- _id: '10135' abstract: - lang: eng text: "Plants maintain the capacity to develop new organs e.g. lateral roots post-embryonically throughout their whole life and thereby flexibly adapt to ever-changing environmental conditions. Plant hormones auxin and cytokinin are the main regulators of the lateral root organogenesis. Additionally to their solo activities, the interaction between auxin and\r\ncytokinin plays crucial role in fine-tuning of lateral root development and growth. In particular, cytokinin modulates auxin distribution within the developing lateral root by affecting the endomembrane trafficking of auxin transporter PIN1 and promoting its vacuolar degradation (Marhavý et al., 2011, 2014). This effect is independent of transcription and\r\ntranslation. Therefore, it suggests novel, non-canonical cytokinin activity occuring possibly on the posttranslational level. Impact of cytokinin and other plant hormones on auxin transporters (including PIN1) on the posttranslational level is described in detail in the introduction part of this thesis in a form of a review (Semeradova et al., 2020). To gain insights into the molecular machinery underlying cytokinin effect on the endomembrane trafficking in the plant cell, in particular on the PIN1 degradation, we conducted two large proteomic screens: 1) Identification of cytokinin binding proteins using\r\nchemical proteomics. 2) Monitoring of proteomic and phosphoproteomic changes upon cytokinin treatment. In the first screen, we identified DYNAMIN RELATED PROTEIN 2A (DRP2A). We found that DRP2A plays a role in cytokinin regulated processes during the plant growth and that cytokinin treatment promotes destabilization of DRP2A protein. However, the role of DRP2A in the PIN1 degradation remains to be elucidated. In the second screen, we found VACUOLAR PROTEIN SORTING 9A (VPS9A). VPS9a plays crucial role in plant’s response to cytokin and in cytokinin mediated PIN1 degradation. Altogether, we identified proteins, which bind to cytokinin and proteins that in response to\r\ncytokinin exhibit significantly changed abundance or phosphorylation pattern. By combining information from these two screens, we can pave our way towards understanding of noncanonical cytokinin effects." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Hana full_name: Semerádová, Hana id: 42FE702E-F248-11E8-B48F-1D18A9856A87 last_name: Semerádová citation: ama: Semerádová H. Molecular mechanisms of the cytokinin-regulated endomembrane trafficking to coordinate plant organogenesis. 2021. doi:10.15479/at:ista:10135 apa: Semerádová, H. (2021). Molecular mechanisms of the cytokinin-regulated endomembrane trafficking to coordinate plant organogenesis. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10135 chicago: Semerádová, Hana. “Molecular Mechanisms of the Cytokinin-Regulated Endomembrane Trafficking to Coordinate Plant Organogenesis.” Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:10135. ieee: H. Semerádová, “Molecular mechanisms of the cytokinin-regulated endomembrane trafficking to coordinate plant organogenesis,” Institute of Science and Technology Austria, 2021. ista: Semerádová H. 2021. Molecular mechanisms of the cytokinin-regulated endomembrane trafficking to coordinate plant organogenesis. Institute of Science and Technology Austria. mla: Semerádová, Hana. Molecular Mechanisms of the Cytokinin-Regulated Endomembrane Trafficking to Coordinate Plant Organogenesis. Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:10135. short: H. Semerádová, Molecular Mechanisms of the Cytokinin-Regulated Endomembrane Trafficking to Coordinate Plant Organogenesis, Institute of Science and Technology Austria, 2021. date_created: 2021-10-13T13:42:48Z date_published: 2021-10-13T00:00:00Z date_updated: 2024-01-25T10:53:29Z day: '13' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: EvBe doi: 10.15479/at:ista:10135 file: - access_level: closed checksum: ce7108853e6cec6224f17cd6429b51fe content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: cziletti date_created: 2021-10-27T07:45:37Z date_updated: 2022-12-20T23:30:05Z embargo_to: open_access file_id: '10186' file_name: Hana_Semeradova_Disertation_Thesis_II_Revised_3.docx file_size: 28508629 relation: source_file - access_level: open_access checksum: 0d7afb846e8e31ec794de47bf44e12ef content_type: application/pdf creator: cziletti date_created: 2021-10-27T07:45:57Z date_updated: 2022-12-20T23:30:05Z embargo: 2022-10-28 file_id: '10187' file_name: Hana_Semeradova_Disertation_Thesis_II_Revised_3PDFA.pdf file_size: 10623525 relation: main_file file_date_updated: 2022-12-20T23:30:05Z has_accepted_license: '1' language: - iso: eng month: '10' oa: 1 oa_version: Published Version project: - _id: 261821BC-B435-11E9-9278-68D0E5697425 grant_number: '24746' name: Molecular mechanisms of the cytokinin regulated endomembrane trafficking to coordinate plant organogenesis. publication_identifier: isbn: - 978-3-99078-014-5 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '9160' relation: part_of_dissertation status: public status: public supervisor: - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 title: Molecular mechanisms of the cytokinin-regulated endomembrane trafficking to coordinate plant organogenesis type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2021' ... --- _id: '9728' abstract: - lang: eng text: "Most real-world flows are multiphase, yet we know little about them compared to their single-phase counterparts. Multiphase flows are more difficult to investigate as their dynamics occur in large parameter space and involve complex phenomena such as preferential concentration, turbulence modulation, non-Newtonian rheology, etc. Over the last few decades, experiments in particle-laden flows have taken a back seat in favour of ever-improving computational resources. However, computers are still not powerful enough to simulate a real-world fluid with millions of finite-size particles. Experiments are essential not only because they offer a reliable way to investigate real-world multiphase flows but also because they serve to validate numerical studies and steer the research in a relevant direction. In this work, we have experimentally investigated particle-laden flows in pipes, and in particular, examined the effect of particles on the laminar-turbulent transition and the drag scaling in turbulent flows.\r\n\r\nFor particle-laden pipe flows, an earlier study [Matas et al., 2003] reported how the sub-critical (i.e., hysteretic) transition that occurs via localised turbulent structures called puffs is affected by the addition of particles. In this study, in addition to this known transition, we found a super-critical transition to a globally fluctuating state with increasing particle concentration. At the same time, the Newtonian-type transition via puffs is delayed to larger Reynolds numbers. At an even higher concentration, only the globally fluctuating state is found. The dynamics of particle-laden flows are hence determined by two competing instabilities that give rise to three flow regimes: Newtonian-type turbulence at low, a particle-induced globally fluctuating state at high, and a coexistence state at intermediate concentrations.\r\n\r\nThe effect of particles on turbulent drag is ambiguous, with studies reporting drag reduction, no net change, and even drag increase. The ambiguity arises because, in addition to particle concentration, particle shape, size, and density also affect the net drag. Even similar particles might affect the flow dissimilarly in different Reynolds number and concentration ranges. In the present study, we explored a wide range of both Reynolds number and concentration, using spherical as well as cylindrical particles. We found that the spherical particles do not reduce drag while the cylindrical particles are drag-reducing within a specific Reynolds number interval. The interval strongly depends on the particle concentration and the relative size of the pipe and particles. Within this interval, the magnitude of drag reduction reaches a maximum. These drag reduction maxima appear to fall onto a distinct power-law curve irrespective of the pipe diameter and particle concentration, and this curve can be considered as the maximum drag reduction asymptote for a given fibre shape. Such an asymptote is well known for polymeric flows but had not been identified for particle-laden flows prior to this work." acknowledged_ssus: - _id: M-Shop alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Nishchal full_name: Agrawal, Nishchal id: 469E6004-F248-11E8-B48F-1D18A9856A87 last_name: Agrawal citation: ama: Agrawal N. Transition to turbulence and drag reduction in particle-laden pipe flows. 2021. doi:10.15479/at:ista:9728 apa: Agrawal, N. (2021). Transition to turbulence and drag reduction in particle-laden pipe flows. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:9728 chicago: Agrawal, Nishchal. “Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.” Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9728. ieee: N. Agrawal, “Transition to turbulence and drag reduction in particle-laden pipe flows,” Institute of Science and Technology Austria, 2021. ista: Agrawal N. 2021. Transition to turbulence and drag reduction in particle-laden pipe flows. Institute of Science and Technology Austria. mla: Agrawal, Nishchal. Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows. Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:9728. short: N. Agrawal, Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows, Institute of Science and Technology Austria, 2021. date_created: 2021-07-27T13:40:30Z date_published: 2021-07-29T00:00:00Z date_updated: 2024-02-28T13:14:39Z day: '29' ddc: - '532' degree_awarded: PhD department: - _id: GradSch - _id: BjHo doi: 10.15479/at:ista:9728 file: - access_level: closed checksum: 77436be3563a90435024307b1b5ee7e8 content_type: application/x-zip-compressed creator: nagrawal date_created: 2021-07-28T13:32:02Z date_updated: 2022-07-29T22:30:05Z embargo_to: open_access file_id: '9744' file_name: Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.zip file_size: 22859658 relation: source_file - access_level: open_access checksum: 72a891d7daba85445c29b868c22575ed content_type: application/pdf creator: nagrawal date_created: 2021-07-28T13:32:05Z date_updated: 2022-07-29T22:30:05Z embargo: 2022-07-28 file_id: '9745' file_name: Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.pdf file_size: 18658048 relation: main_file file_date_updated: 2022-07-29T22:30:05Z has_accepted_license: '1' keyword: - Drag Reduction - Transition to Turbulence - Multiphase Flows - particle Laden Flows - Complex Flows - Experiments - Fluid Dynamics language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: '118' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '6189' relation: part_of_dissertation status: public status: public supervisor: - first_name: Björn full_name: Hof, Björn id: 3A374330-F248-11E8-B48F-1D18A9856A87 last_name: Hof orcid: 0000-0003-2057-2754 title: Transition to turbulence and drag reduction in particle-laden pipe flows tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 year: '2021' ... --- _id: '10336' abstract: - lang: eng text: Biological membranes can dramatically accelerate the aggregation of normally soluble protein molecules into amyloid fibrils and alter the fibril morphologies, yet the molecular mechanisms through which this accelerated nucleation takes place are not yet understood. Here, we develop a coarse-grained model to systematically explore the effect that the structural properties of the lipid membrane and the nature of protein–membrane interactions have on the nucleation rates of amyloid fibrils. We identify two physically distinct nucleation pathways—protein-rich and lipid-rich—and quantify how the membrane fluidity and protein–membrane affinity control the relative importance of those molecular pathways. We find that the membrane’s susceptibility to reshaping and being incorporated into the fibrillar aggregates is a key determinant of its ability to promote protein aggregation. We then characterize the rates and the free-energy profile associated with this heterogeneous nucleation process, in which the surface itself participates in the aggregate structure. Finally, we compare quantitatively our data to experiments on membrane-catalyzed amyloid aggregation of α-synuclein, a protein implicated in Parkinson’s disease that predominately nucleates on membranes. More generally, our results provide a framework for understanding macromolecular aggregation on lipid membranes in a broad biological and biotechnological context. acknowledgement: We thank T. C. T. Michaels for reading the manuscript. This work was supported by the Academy of Medical Science (J.K. and A.Š.), the Cambridge Center for Misfolding Diseases (T.P.J.K.), the Biotechnology and Biological Sciences Research Council (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the European Research Council Grant PhysProt Agreement 337969, the Wellcome Trust (A.Š. and T.P.J.K.), the Royal Society (A.Š.), the Medical Research Council (J.K. and A.Š.), and the UK Materials and Molecular Modeling Hub for computational resources, which is partially funded by Engineering and Physical Sciences Research Council Grant EP/P020194/1. article_processing_charge: No article_type: original author: - first_name: Johannes full_name: Krausser, Johannes last_name: Krausser - first_name: Tuomas P. J. full_name: Knowles, Tuomas P. J. last_name: Knowles - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 citation: ama: Krausser J, Knowles TPJ, Šarić A. Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. 2020;117(52):33090-33098. doi:10.1073/pnas.2007694117 apa: Krausser, J., Knowles, T. P. J., & Šarić, A. (2020). Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2007694117 chicago: Krausser, Johannes, Tuomas P. J. Knowles, and Anđela Šarić. “Physical Mechanisms of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2007694117. ieee: J. Krausser, T. P. J. Knowles, and A. Šarić, “Physical mechanisms of amyloid nucleation on fluid membranes,” Proceedings of the National Academy of Sciences, vol. 117, no. 52. National Academy of Sciences, pp. 33090–33098, 2020. ista: Krausser J, Knowles TPJ, Šarić A. 2020. Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. 117(52), 33090–33098. mla: Krausser, Johannes, et al. “Physical Mechanisms of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy of Sciences, vol. 117, no. 52, National Academy of Sciences, 2020, pp. 33090–98, doi:10.1073/pnas.2007694117. short: J. Krausser, T.P.J. Knowles, A. Šarić, Proceedings of the National Academy of Sciences 117 (2020) 33090–33098. date_created: 2021-11-25T15:07:09Z date_published: 2020-12-16T00:00:00Z date_updated: 2021-11-25T15:35:58Z day: '16' doi: 10.1073/pnas.2007694117 extern: '1' external_id: pmid: - '33328273' intvolume: ' 117' issue: '52' language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2019.12.22.886267v2 month: '12' oa: 1 oa_version: Published Version page: 33090-33098 pmid: 1 publication: Proceedings of the National Academy of Sciences publication_identifier: eissn: - 1091-6490 issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences quality_controlled: '1' scopus_import: '1' status: public title: Physical mechanisms of amyloid nucleation on fluid membranes type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 117 year: '2020' ... --- _id: '10342' abstract: - lang: eng text: The blood-brain barrier is made of polarized brain endothelial cells (BECs) phenotypically conditioned by the central nervous system (CNS). Although transport across BECs is of paramount importance for nutrient uptake as well as ridding the brain of waste products, the intracellular sorting mechanisms that regulate successful receptor-mediated transcytosis in BECs remain to be elucidated. Here, we used a synthetic multivalent system with tunable avidity to the low-density lipoprotein receptor–related protein 1 (LRP1) to investigate the mechanisms of transport across BECs. We used a combination of conventional and super-resolution microscopy, both in vivo and in vitro, accompanied with biophysical modeling of transport kinetics and membrane-bound interactions to elucidate the role of membrane-sculpting protein syndapin-2 on fast transport via tubule formation. We show that high-avidity cargo biases the LRP1 toward internalization associated with fast degradation, while mid-avidity augments the formation of syndapin-2 tubular carriers promoting a fast shuttling across. acknowledgement: 'Funding: G.B. thanks the ERC for the starting grant (MEViC 278793) and consolidator award (CheSSTaG 769798), EPSRC/BTG Healthcare Partnership (EP/I001697/1), EPSRC Established Career Fellowship (EP/N026322/1), EPSRC/SomaNautix Healthcare Partnership EP/R024723/1, and Children with Cancer UK for the research project (16-227). X.T. and G.B. thank that Anhui 100 Talent program for facilitating data sharing and research visits. A.D.-C. and L.R. acknowledge the Royal Society for a Newton fellowship and the Marie Skłodowska-Curie Actions for a European Fellowship. Author contributions: X.T. prepared and characterized POs, performed all the fast imaging in both conventional and STED microscopy, set up the initial BBB model, encapsulated the PtA2 in POs, and supervised the PtA2-PO animal work. D.M.L. prepared and characterized POs; performed all the permeability studies, PLA assays, WB and associated data analysis, and part of the colocalization assays; and performed experiments with the shRNA for knockdown of syndapin-2. E.S. prepared and characterized POs and performed part of colocalization assays and Cy7-labeled PO animal experiments. S.N. prepared and characterized POs and performed part of the colocalization and inhibition assays. G.F. designed, performed, and analyzed the agent-based simulations of transcytosis. J.F. designed the image-based algorithm to analyze the PLA data. D.M. prepared and characterized POs and helped with Cy7-labeled PO animal experiments. A.A. performed TEM imaging of the POs. A.P. and A.D.-C. synthesized the dye- and peptide-functionalized and pristine copolymers. M.V., L.H.-K., and A.Š. designed, performed, and analyzed the MD simulations. Z.Z. supervised and supported STED imaging. P.X., B.F., and Y.T. synthesized and characterized the PtA2 compound. L.L. performed some of the animal work. L.R. supported and helped with the BBB characterization. G.B. analyzed all fast imaging and supervised and coordinated the overall work. X.T., D.M.L., E.S., and G.B. wrote the manuscript. Competing interests: The authors declare that part of the work is associated with the UCL spin-out company SomaNautix Ltd. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors.' article_number: 'eabc4397 ' article_processing_charge: No article_type: original author: - first_name: Xiaohe full_name: Tian, Xiaohe last_name: Tian - first_name: Diana M. full_name: Leite, Diana M. last_name: Leite - first_name: Edoardo full_name: Scarpa, Edoardo last_name: Scarpa - first_name: Sophie full_name: Nyberg, Sophie last_name: Nyberg - first_name: Gavin full_name: Fullstone, Gavin last_name: Fullstone - first_name: Joe full_name: Forth, Joe last_name: Forth - first_name: Diana full_name: Matias, Diana last_name: Matias - first_name: Azzurra full_name: Apriceno, Azzurra last_name: Apriceno - first_name: Alessandro full_name: Poma, Alessandro last_name: Poma - first_name: Aroa full_name: Duro-Castano, Aroa last_name: Duro-Castano - first_name: Manish full_name: Vuyyuru, Manish last_name: Vuyyuru - first_name: Lena full_name: Harker-Kirschneck, Lena last_name: Harker-Kirschneck - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Zhongping full_name: Zhang, Zhongping last_name: Zhang - first_name: Pan full_name: Xiang, Pan last_name: Xiang - first_name: Bin full_name: Fang, Bin last_name: Fang - first_name: Yupeng full_name: Tian, Yupeng last_name: Tian - first_name: Lei full_name: Luo, Lei last_name: Luo - first_name: Loris full_name: Rizzello, Loris last_name: Rizzello - first_name: Giuseppe full_name: Battaglia, Giuseppe last_name: Battaglia citation: ama: 'Tian X, Leite DM, Scarpa E, et al. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 2020;6(48). doi:10.1126/sciadv.abc4397' apa: 'Tian, X., Leite, D. M., Scarpa, E., Nyberg, S., Fullstone, G., Forth, J., … Battaglia, G. (2020). On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.abc4397' chicago: 'Tian, Xiaohe, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone, Joe Forth, Diana Matias, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.abc4397.' ieee: 'X. Tian et al., “On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias,” Science Advances, vol. 6, no. 48. American Association for the Advancement of Science, 2020.' ista: 'Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G. 2020. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 6(48), eabc4397.' mla: 'Tian, Xiaohe, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances, vol. 6, no. 48, eabc4397, American Association for the Advancement of Science, 2020, doi:10.1126/sciadv.abc4397.' short: X. Tian, D.M. Leite, E. Scarpa, S. Nyberg, G. Fullstone, J. Forth, D. Matias, A. Apriceno, A. Poma, A. Duro-Castano, M. Vuyyuru, L. Harker-Kirschneck, A. Šarić, Z. Zhang, P. Xiang, B. Fang, Y. Tian, L. Luo, L. Rizzello, G. Battaglia, Science Advances 6 (2020). date_created: 2021-11-26T06:40:28Z date_published: 2020-11-27T00:00:00Z date_updated: 2021-11-26T07:00:24Z day: '27' ddc: - '611' doi: 10.1126/sciadv.abc4397 extern: '1' external_id: pmid: - '33246953' file: - access_level: open_access checksum: 3ba2eca975930cdb0b1ce1ae876885a7 content_type: application/pdf creator: cchlebak date_created: 2021-11-26T06:50:09Z date_updated: 2021-11-26T06:50:09Z file_id: '10343' file_name: 2020_SciAdv_Tian.pdf file_size: 10381298 relation: main_file success: 1 file_date_updated: 2021-11-26T06:50:09Z has_accepted_license: '1' intvolume: ' 6' issue: '48' keyword: - multidisciplinary language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2020.04.04.025866v1 month: '11' oa: 1 oa_version: Published Version pmid: 1 publication: Science Advances publication_identifier: issn: - 2375-2548 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: 'On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 6 year: '2020' ... --- _id: '10344' abstract: - lang: eng text: In this study, we investigate the role of the surface patterning of nanostructures for cell membrane reshaping. To accomplish this, we combine an evolutionary algorithm with coarse-grained molecular dynamics simulations and explore the solution space of ligand patterns on a nanoparticle that promote efficient and reliable cell uptake. Surprisingly, we find that in the regime of low ligand number the best-performing structures are characterized by ligands arranged into long one-dimensional chains that pattern the surface of the particle. We show that these chains of ligands provide particles with high rotational freedom and they lower the free energy barrier for membrane crossing. Our approach reveals a set of nonintuitive design rules that can be used to inform artificial nanoparticle construction and the search for inhibitors of viral entry. acknowledgement: We acknowledge support from EPSRC (J. C. F.), MRC (B. B. and A. Š.), the ERC StG 802960 “NEPA” (J. K. and A. Š.), the Royal Society (A. Š.), and the United Kingdom Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC (EP/P020194/1). article_number: '228101' article_processing_charge: No article_type: original author: - first_name: Joel C. full_name: Forster, Joel C. last_name: Forster - first_name: Johannes full_name: Krausser, Johannes last_name: Krausser - first_name: Manish R. full_name: Vuyyuru, Manish R. last_name: Vuyyuru - first_name: Buzz full_name: Baum, Buzz last_name: Baum - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 citation: ama: Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. 2020;125(22). doi:10.1103/physrevlett.125.228101 apa: Forster, J. C., Krausser, J., Vuyyuru, M. R., Baum, B., & Šarić, A. (2020). Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. American Physical Society. https://doi.org/10.1103/physrevlett.125.228101 chicago: Forster, Joel C., Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, and Anđela Šarić. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.” Physical Review Letters. American Physical Society, 2020. https://doi.org/10.1103/physrevlett.125.228101. ieee: J. C. Forster, J. Krausser, M. R. Vuyyuru, B. Baum, and A. Šarić, “Exploring the design rules for efficient membrane-reshaping nanostructures,” Physical Review Letters, vol. 125, no. 22. American Physical Society, 2020. ista: Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. 2020. Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. 125(22), 228101. mla: Forster, Joel C., et al. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.” Physical Review Letters, vol. 125, no. 22, 228101, American Physical Society, 2020, doi:10.1103/physrevlett.125.228101. short: J.C. Forster, J. Krausser, M.R. Vuyyuru, B. Baum, A. Šarić, Physical Review Letters 125 (2020). date_created: 2021-11-26T07:10:43Z date_published: 2020-11-23T00:00:00Z date_updated: 2021-11-30T08:33:14Z day: '23' ddc: - '530' doi: 10.1103/physrevlett.125.228101 extern: '1' external_id: pmid: - '33315453' file: - access_level: open_access checksum: fbf2e1415e332d6add90222d60401a1d content_type: application/pdf creator: cchlebak date_created: 2021-11-26T07:16:49Z date_updated: 2021-11-26T07:16:49Z file_id: '10345' file_name: 2020_PhysRevLett_Forster.pdf file_size: 844353 relation: main_file success: 1 file_date_updated: 2021-11-26T07:16:49Z has_accepted_license: '1' intvolume: ' 125' issue: '22' language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2020.02.27.968149v1 month: '11' oa: 1 oa_version: Published Version pmid: 1 publication: Physical Review Letters publication_identifier: eissn: - 1079-7114 issn: - 0031-9007 publication_status: published publisher: American Physical Society quality_controlled: '1' scopus_import: '1' status: public title: Exploring the design rules for efficient membrane-reshaping nanostructures tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 125 year: '2020' ... --- _id: '10341' abstract: - lang: eng text: Tracing the motion of macromolecules, viruses, and nanoparticles adsorbed onto cell membranes is currently the most direct way of probing the complex dynamic interactions behind vital biological processes, including cell signalling, trafficking, and viral infection. The resulting trajectories are usually consistent with some type of anomalous diffusion, but the molecular origins behind the observed anomalous behaviour are usually not obvious. Here we use coarse-grained molecular dynamics simulations to help identify the physical mechanisms that can give rise to experimentally observed trajectories of nanoscopic objects moving on biological membranes. We find that diffusion on membranes of high fluidities typically results in normal diffusion of the adsorbed nanoparticle, irrespective of the concentration of receptors, receptor clustering, or multivalent interactions between the particle and membrane receptors. Gel-like membranes on the other hand result in anomalous diffusion of the particle, which becomes more pronounced at higher receptor concentrations. This anomalous diffusion is characterised by local particle trapping in the regions of high receptor concentrations and fast hopping between such regions. The normal diffusion is recovered in the limit where the gel membrane is saturated with receptors. We conclude that hindered receptor diffusivity can be a common reason behind the observed anomalous diffusion of viruses, vesicles, and nanoparticles adsorbed on cell and model membranes. Our results enable direct comparison with experiments and offer a new route for interpreting motility experiments on cell membranes. acknowledgement: We thank Jessica McQuade for her input at the start of the project. We acknowledge support from the ERASMUS Placement Programme (V. E. D.), the UCL Institute for the Physics of Living Systems (V. E. D. and A. Š.), the UCL Global Engagement Fund (L. M. C. J.), and the Royal Society (A. Š.). article_processing_charge: No article_type: original author: - first_name: V. E. full_name: Debets, V. E. last_name: Debets - first_name: L. M. C. full_name: Janssen, L. M. C. last_name: Janssen - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 citation: ama: Debets VE, Janssen LMC, Šarić A. Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. 2020;16(47):10628-10639. doi:10.1039/d0sm00712a apa: Debets, V. E., Janssen, L. M. C., & Šarić, A. (2020). Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. Royal Society of Chemistry. https://doi.org/10.1039/d0sm00712a chicago: Debets, V. E., L. M. C. Janssen, and Anđela Šarić. “Characterising the Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft Matter. Royal Society of Chemistry, 2020. https://doi.org/10.1039/d0sm00712a. ieee: V. E. Debets, L. M. C. Janssen, and A. Šarić, “Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes,” Soft Matter, vol. 16, no. 47. Royal Society of Chemistry, pp. 10628–10639, 2020. ista: Debets VE, Janssen LMC, Šarić A. 2020. Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. 16(47), 10628–10639. mla: Debets, V. E., et al. “Characterising the Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft Matter, vol. 16, no. 47, Royal Society of Chemistry, 2020, pp. 10628–39, doi:10.1039/d0sm00712a. short: V.E. Debets, L.M.C. Janssen, A. Šarić, Soft Matter 16 (2020) 10628–10639. date_created: 2021-11-26T06:29:41Z date_published: 2020-10-06T00:00:00Z date_updated: 2021-11-26T07:00:33Z day: '06' doi: 10.1039/d0sm00712a extern: '1' external_id: pmid: - '33084724' intvolume: ' 16' issue: '47' keyword: - condensed matter physics - general chemistry language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2020.05.01.071761v1 month: '10' oa: 1 oa_version: Published Version page: 10628-10639 pmid: 1 publication: Soft Matter publication_identifier: issn: - 1744-683X - 1744-6848 publication_status: published publisher: Royal Society of Chemistry quality_controlled: '1' scopus_import: '1' status: public title: Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 16 year: '2020' ... --- _id: '10346' abstract: - lang: eng text: One of the most robust examples of self-assembly in living organisms is the formation of collagen architectures. Collagen type I molecules are a crucial component of the extracellular matrix, where they self-assemble into fibrils of well-defined axial striped patterns. This striped fibrillar pattern is preserved across the animal kingdom and is important for the determination of cell phenotype, cell adhesion, and tissue regulation and signaling. The understanding of the physical processes that determine such a robust morphology of self-assembled collagen fibrils is currently almost completely missing. Here, we develop a minimal coarse-grained computational model to identify the physical principles of the assembly of collagen-mimetic molecules. We find that screened electrostatic interactions can drive the formation of collagen-like filaments of well-defined striped morphologies. The fibril axial pattern is determined solely by the distribution of charges on the molecule and is robust to the changes in protein concentration, monomer rigidity, and environmental conditions. We show that the striped fibrillar pattern cannot be easily predicted from the interactions between two monomers but is an emergent result of multibody interactions. Our results can help address collagen remodeling in diseases and aging and guide the design of collagen scaffolds for biotechnological applications. acknowledgement: We thank Melinda Duer, Patrick Mesquida, Lucy Colwell, Lucie Liu, Daan Frenkel, and Ivan Palaia for helpful discussions. We acknowledge support from the Engineering and Physical Sciences Research Council (A.E.H., L.K.D., and A.Š.), Biotechnology and Biological Sciences Research Council LIDo programme (N.G.G. and C.A.B.), the Royal Society (A.Š.), and the UK Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC ( EP/P020194/1). article_processing_charge: No article_type: original author: - first_name: Anne E. full_name: Hafner, Anne E. last_name: Hafner - first_name: Noemi G. full_name: Gyori, Noemi G. last_name: Gyori - first_name: Ciaran A. full_name: Bench, Ciaran A. last_name: Bench - first_name: Luke K. full_name: Davis, Luke K. last_name: Davis - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 citation: ama: Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. 2020;119(9):1791-1799. doi:10.1016/j.bpj.2020.09.013 apa: Hafner, A. E., Gyori, N. G., Bench, C. A., Davis, L. K., & Šarić, A. (2020). Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. Cell Press. https://doi.org/10.1016/j.bpj.2020.09.013 chicago: Hafner, Anne E., Noemi G. Gyori, Ciaran A. Bench, Luke K. Davis, and Anđela Šarić. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.” Biophysical Journal. Cell Press, 2020. https://doi.org/10.1016/j.bpj.2020.09.013. ieee: A. E. Hafner, N. G. Gyori, C. A. Bench, L. K. Davis, and A. Šarić, “Modeling fibrillogenesis of collagen-mimetic molecules,” Biophysical Journal, vol. 119, no. 9. Cell Press, pp. 1791–1799, 2020. ista: Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. 2020. Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. 119(9), 1791–1799. mla: Hafner, Anne E., et al. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.” Biophysical Journal, vol. 119, no. 9, Cell Press, 2020, pp. 1791–99, doi:10.1016/j.bpj.2020.09.013. short: A.E. Hafner, N.G. Gyori, C.A. Bench, L.K. Davis, A. Šarić, Biophysical Journal 119 (2020) 1791–1799. date_created: 2021-11-26T07:27:24Z date_published: 2020-09-23T00:00:00Z date_updated: 2021-11-26T07:45:24Z day: '23' doi: 10.1016/j.bpj.2020.09.013 extern: '1' external_id: pmid: - '33049216' intvolume: ' 119' issue: '9' keyword: - biophysics language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2020.06.08.140061v1 month: '09' oa: 1 oa_version: Published Version page: 1791-1799 pmid: 1 publication: Biophysical Journal publication_identifier: issn: - 0006-3495 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: Modeling fibrillogenesis of collagen-mimetic molecules type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 119 year: '2020' ... --- _id: '10350' abstract: - lang: eng text: The misfolding and aberrant aggregation of proteins into fibrillar structures is a key factor in some of the most prevalent human diseases, including diabetes and dementia. Low molecular weight oligomers are thought to be a central factor in the pathology of these diseases, as well as critical intermediates in the fibril formation process, and as such have received much recent attention. Moreover, on-pathway oligomeric intermediates are potential targets for therapeutic strategies aimed at interrupting the fibril formation process. However, a consistent framework for distinguishing on-pathway from off-pathway oligomers has hitherto been lacking and, in particular, no consensus definition of on- and off-pathway oligomers is available. In this paper, we argue that a non-binary definition of oligomers' contribution to fibril-forming pathways may be more informative and we suggest a quantitative framework, in which each oligomeric species is assigned a value between 0 and 1 describing its relative contribution to the formation of fibrils. First, we clarify the distinction between oligomers and fibrils, and then we use the formalism of reaction networks to develop a general definition for on-pathway oligomers, that yields meaningful classifications in the context of amyloid formation. By applying these concepts to Monte Carlo simulations of a minimal aggregating system, and by revisiting several previous studies of amyloid oligomers in light of our new framework, we demonstrate how to perform these classifications in practice. For each oligomeric species we obtain the degree to which it is on-pathway, highlighting the most effective pharmaceutical targets for the inhibition of amyloid fibril formation. acknowledgement: We are grateful to the Schiff Foundation (AJD), Peterhouse, Cambridge (TCTM), the Swiss National Science foundation (TCTM), Ramon Jenkins Fellowship, Sidney Sussex, Cambridge (GM), the Royal Society (AŠ), the Academy of Medical Sciences and Wellcome Trust (AŠ), the Danish Research Council (MK), the Lundbeck Foundation (MK), the Swedish Research Council (SL), the Wellcome Trust (TPJK), the Cambridge Centre for Misfolding Diseases (TPJK), the BBSRC (TPJK), the Frances and Augustus Newman Foundation (TPJK) for financial support. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) through the ERC grants PhysProt (agreement no. 337969), MAMBA (agreement no. 340890) and NovoNordiskFonden (SL). article_processing_charge: No article_type: original author: - first_name: Alexander J. full_name: Dear, Alexander J. last_name: Dear - first_name: Georg full_name: Meisl, Georg last_name: Meisl - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Thomas C. T. full_name: Michaels, Thomas C. T. last_name: Michaels - first_name: Magnus full_name: Kjaergaard, Magnus last_name: Kjaergaard - first_name: Sara full_name: Linse, Sara last_name: Linse - first_name: Tuomas P. J. full_name: Knowles, Tuomas P. J. last_name: Knowles citation: ama: Dear AJ, Meisl G, Šarić A, et al. Identification of on- and off-pathway oligomers in amyloid fibril formation. Chemical Science. 2020;11(24):6236-6247. doi:10.1039/c9sc06501f apa: Dear, A. J., Meisl, G., Šarić, A., Michaels, T. C. T., Kjaergaard, M., Linse, S., & Knowles, T. P. J. (2020). Identification of on- and off-pathway oligomers in amyloid fibril formation. Chemical Science. Royal Society of Chemistry. https://doi.org/10.1039/c9sc06501f chicago: Dear, Alexander J., Georg Meisl, Anđela Šarić, Thomas C. T. Michaels, Magnus Kjaergaard, Sara Linse, and Tuomas P. J. Knowles. “Identification of On- and off-Pathway Oligomers in Amyloid Fibril Formation.” Chemical Science. Royal Society of Chemistry, 2020. https://doi.org/10.1039/c9sc06501f. ieee: A. J. Dear et al., “Identification of on- and off-pathway oligomers in amyloid fibril formation,” Chemical Science, vol. 11, no. 24. Royal Society of Chemistry, pp. 6236–6247, 2020. ista: Dear AJ, Meisl G, Šarić A, Michaels TCT, Kjaergaard M, Linse S, Knowles TPJ. 2020. Identification of on- and off-pathway oligomers in amyloid fibril formation. Chemical Science. 11(24), 6236–6247. mla: Dear, Alexander J., et al. “Identification of On- and off-Pathway Oligomers in Amyloid Fibril Formation.” Chemical Science, vol. 11, no. 24, Royal Society of Chemistry, 2020, pp. 6236–47, doi:10.1039/c9sc06501f. short: A.J. Dear, G. Meisl, A. Šarić, T.C.T. Michaels, M. Kjaergaard, S. Linse, T.P.J. Knowles, Chemical Science 11 (2020) 6236–6247. date_created: 2021-11-26T09:08:19Z date_published: 2020-06-08T00:00:00Z date_updated: 2021-11-26T11:21:20Z day: '08' doi: 10.1039/c9sc06501f extern: '1' external_id: pmid: - '32953019' intvolume: ' 11' issue: '24' keyword: - general chemistry language: - iso: eng license: https://creativecommons.org/licenses/by-nc/3.0/ main_file_link: - open_access: '1' url: https://pubs.rsc.org/en/content/articlehtml/2020/sc/c9sc06501f month: '06' oa: 1 oa_version: Published Version page: 6236-6247 pmid: 1 publication: Chemical Science publication_identifier: eissn: - 2041-6539 issn: - 2041-6520 publication_status: published publisher: Royal Society of Chemistry quality_controlled: '1' scopus_import: '1' status: public title: Identification of on- and off-pathway oligomers in amyloid fibril formation tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/3.0/legalcode name: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) short: CC BY-NC (3.0) type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 11 year: '2020' ... --- _id: '10349' abstract: - lang: eng text: Sulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III–mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control. acknowledgement: "We thank the MRC LMCB at UCL for their support; the flow cytometry STP at the Francis Crick Institute for assistance, with special thanks to S. Purewal and D. Davis; C. Bertoli for mentorship\r\nand advice; J. M. Garcia-Arcos for help early on in this project; the entire Baum lab for their input throughout the project; the Albers lab for advice and reagents, with special thanks to M. Van Wolferen and S. Albers; the members of the Wellcome consortium for archaeal cytoskeleton studies for advice and comments; and J. Löwe, S. Oliferenko, M. Balasubramanian, and D. Gerlich for discussions and advice on the manuscript. N.P.R. and S.B. would like to thank N. Rzechorzek, A. Simon, and S. Anjum for discussion and advice." article_processing_charge: No article_type: original author: - first_name: Gabriel full_name: Tarrason Risa, Gabriel last_name: Tarrason Risa - first_name: Fredrik full_name: Hurtig, Fredrik last_name: Hurtig - first_name: Sian full_name: Bray, Sian last_name: Bray - first_name: Anne E. full_name: Hafner, Anne E. last_name: Hafner - first_name: Lena full_name: Harker-Kirschneck, Lena last_name: Harker-Kirschneck - first_name: Peter full_name: Faull, Peter last_name: Faull - first_name: Colin full_name: Davis, Colin last_name: Davis - first_name: Dimitra full_name: Papatziamou, Dimitra last_name: Papatziamou - first_name: Delyan R. full_name: Mutavchiev, Delyan R. last_name: Mutavchiev - first_name: Catherine full_name: Fan, Catherine last_name: Fan - first_name: Leticia full_name: Meneguello, Leticia last_name: Meneguello - first_name: Andre full_name: Arashiro Pulschen, Andre last_name: Arashiro Pulschen - first_name: Gautam full_name: Dey, Gautam last_name: Dey - first_name: Siân full_name: Culley, Siân last_name: Culley - first_name: Mairi full_name: Kilkenny, Mairi last_name: Kilkenny - first_name: Diorge P. full_name: Souza, Diorge P. last_name: Souza - first_name: Luca full_name: Pellegrini, Luca last_name: Pellegrini - first_name: Robertus A. M. full_name: de Bruin, Robertus A. M. last_name: de Bruin - first_name: Ricardo full_name: Henriques, Ricardo last_name: Henriques - first_name: Ambrosius P. full_name: Snijders, Ambrosius P. last_name: Snijders - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Ann-Christin full_name: Lindås, Ann-Christin last_name: Lindås - first_name: Nicholas P. full_name: Robinson, Nicholas P. last_name: Robinson - first_name: Buzz full_name: Baum, Buzz last_name: Baum citation: ama: Tarrason Risa G, Hurtig F, Bray S, et al. The proteasome controls ESCRT-III–mediated cell division in an archaeon. Science. 2020;369(6504). doi:10.1126/science.aaz2532 apa: Tarrason Risa, G., Hurtig, F., Bray, S., Hafner, A. E., Harker-Kirschneck, L., Faull, P., … Baum, B. (2020). The proteasome controls ESCRT-III–mediated cell division in an archaeon. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aaz2532 chicago: Tarrason Risa, Gabriel, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena Harker-Kirschneck, Peter Faull, Colin Davis, et al. “The Proteasome Controls ESCRT-III–Mediated Cell Division in an Archaeon.” Science. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/science.aaz2532. ieee: G. Tarrason Risa et al., “The proteasome controls ESCRT-III–mediated cell division in an archaeon,” Science, vol. 369, no. 6504. American Association for the Advancement of Science, 2020. ista: Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P, Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques R, Snijders AP, Šarić A, Lindås A-C, Robinson NP, Baum B. 2020. The proteasome controls ESCRT-III–mediated cell division in an archaeon. Science. 369(6504). mla: Tarrason Risa, Gabriel, et al. “The Proteasome Controls ESCRT-III–Mediated Cell Division in an Archaeon.” Science, vol. 369, no. 6504, American Association for the Advancement of Science, 2020, doi:10.1126/science.aaz2532. short: G. Tarrason Risa, F. Hurtig, S. Bray, A.E. Hafner, L. Harker-Kirschneck, P. Faull, C. Davis, D. Papatziamou, D.R. Mutavchiev, C. Fan, L. Meneguello, A. Arashiro Pulschen, G. Dey, S. Culley, M. Kilkenny, D.P. Souza, L. Pellegrini, R.A.M. de Bruin, R. Henriques, A.P. Snijders, A. Šarić, A.-C. Lindås, N.P. Robinson, B. Baum, Science 369 (2020). date_created: 2021-11-26T08:21:34Z date_published: 2020-08-07T00:00:00Z date_updated: 2021-11-26T08:58:33Z day: '07' doi: 10.1126/science.aaz2532 extern: '1' external_id: pmid: - '32764038' intvolume: ' 369' issue: '6504' keyword: - multidisciplinary language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/774273v1 month: '08' oa: 1 oa_version: Preprint pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: The proteasome controls ESCRT-III–mediated cell division in an archaeon type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 369 year: '2020' ... --- _id: '10347' abstract: - lang: eng text: Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril formation is critical to the development of potential therapeutics against protein-misfolding diseases. A fundamental challenge for progress is the range of possible target species and the disparate timescales involved, since the aggregating proteins are simultaneously the reactants, products, intermediates, and catalysts of the reaction. It is a complex problem, therefore, to choose the states of the aggregating proteins that should be bound by the compounds to achieve the most potent inhibition. We present here a comprehensive kinetic theory of amyloid-aggregation inhibition that reveals the fundamental thermodynamic and kinetic signatures characterizing effective inhibitors by identifying quantitative relationships between the aggregation and binding rate constants. These results provide general physical laws to guide the design and optimization of inhibitors of amyloid-fibril formation, revealing in particular the important role of on-rates in the binding of the inhibitors. acknowledgement: We acknowledge support from Peterhouse, Cambridge (T.C.T.M.); the Swiss National Science Foundation (T.C.T.M.); the Royal Society (A.S. and S.C.); the Academy of Medical Sciences (A.S.); Sidney Sussex College, Cambridge (G.M.); Newnham College, Cambridge (G.T.H.); the Wellcome Trust (T.P.J.K.); the Cambridge Center for Misfolding Diseases (T.P.J.K. and M.V.); the Biotechnology and Biological Sciences Research Council (T.P.J.K.); the Frances and Augustus Newman Foundation (T.P.J.K.); and the Synapsis Foundation for Alzheimer’s disease (P.A.). The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Seventh Framework Program (FP7/2007-2013) through the ERC Grant PhysProt (Agreement 337969). article_processing_charge: No article_type: original author: - first_name: Thomas C. T. full_name: Michaels, Thomas C. T. last_name: Michaels - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Georg full_name: Meisl, Georg last_name: Meisl - first_name: Gabriella T. full_name: Heller, Gabriella T. last_name: Heller - first_name: Samo full_name: Curk, Samo last_name: Curk - first_name: Paolo full_name: Arosio, Paolo last_name: Arosio - first_name: Sara full_name: Linse, Sara last_name: Linse - first_name: Christopher M. full_name: Dobson, Christopher M. last_name: Dobson - first_name: Michele full_name: Vendruscolo, Michele last_name: Vendruscolo - first_name: Tuomas P. J. full_name: Knowles, Tuomas P. J. last_name: Knowles citation: ama: Michaels TCT, Šarić A, Meisl G, et al. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. 2020;117(39):24251-24257. doi:10.1073/pnas.2006684117 apa: Michaels, T. C. T., Šarić, A., Meisl, G., Heller, G. T., Curk, S., Arosio, P., … Knowles, T. P. J. (2020). Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2006684117 chicago: Michaels, Thomas C. T., Anđela Šarić, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, and Tuomas P. J. Knowles. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation Inhibitors.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2006684117. ieee: T. C. T. Michaels et al., “Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors,” Proceedings of the National Academy of Sciences, vol. 117, no. 39. National Academy of Sciences, pp. 24251–24257, 2020. ista: Michaels TCT, Šarić A, Meisl G, Heller GT, Curk S, Arosio P, Linse S, Dobson CM, Vendruscolo M, Knowles TPJ. 2020. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. 117(39), 24251–24257. mla: Michaels, Thomas C. T., et al. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation Inhibitors.” Proceedings of the National Academy of Sciences, vol. 117, no. 39, National Academy of Sciences, 2020, pp. 24251–57, doi:10.1073/pnas.2006684117. short: T.C.T. Michaels, A. Šarić, G. Meisl, G.T. Heller, S. Curk, P. Arosio, S. Linse, C.M. Dobson, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National Academy of Sciences 117 (2020) 24251–24257. date_created: 2021-11-26T07:48:27Z date_published: 2020-09-14T00:00:00Z date_updated: 2021-11-26T08:59:06Z day: '14' doi: 10.1073/pnas.2006684117 extern: '1' external_id: pmid: - '32929030' intvolume: ' 117' issue: '39' keyword: - multidisciplinary language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2020.02.22.960716 month: '09' oa: 1 oa_version: Published Version page: 24251-24257 pmid: 1 publication: Proceedings of the National Academy of Sciences publication_identifier: eissn: - 1091-6490 issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences quality_controlled: '1' scopus_import: '1' status: public title: Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 117 year: '2020' ... --- _id: '10351' abstract: - lang: eng text: Oligomeric species populated during the aggregation of the Aβ42 peptide have been identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental molecular pathways that control their dynamics have yet to be elucidated. By developing a general approach that combines theory, experiment and simulation, we reveal, in molecular detail, the mechanisms of Aβ42 oligomer dynamics during amyloid fibril formation. Even though all mature amyloid fibrils must originate as oligomers, we found that most Aβ42 oligomers dissociate into their monomeric precursors without forming new fibrils. Only a minority of oligomers converts into fibrillar structures. Moreover, the heterogeneous ensemble of oligomeric species interconverts on timescales comparable to those of aggregation. Our results identify fundamentally new steps that could be targeted by therapeutic interventions designed to combat protein misfolding diseases. acknowledgement: We acknowledge support from Peterhouse (T.C.T.M.), the Swiss National Science foundation (T.C.T.M.), the Royal Society (A.Š.), the Academy of Medical Sciences (A.Š.), the UCL Institute for the Physics of Living Systems (S.C.), Sidney Sussex College (G.M.), the Wellcome Trust (A.Š., M.V., C.M.D. and T.P.J.K.), the Schiff Foundation (A.J.D.), the Cambridge Centre for Misfolding Diseases (M.V., C.M.D. and T.P.J.K.), the BBSRC (C.M.D. and T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the Swedish Research Council (S.L.) and the ERC grant MAMBA (S.L., agreement no. 340890). The research that led to these results received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) through the ERC grant PhysProt (agreement no. 337969). article_processing_charge: No article_type: original author: - first_name: Thomas C. T. full_name: Michaels, Thomas C. T. last_name: Michaels - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Samo full_name: Curk, Samo last_name: Curk - first_name: Katja full_name: Bernfur, Katja last_name: Bernfur - first_name: Paolo full_name: Arosio, Paolo last_name: Arosio - first_name: Georg full_name: Meisl, Georg last_name: Meisl - first_name: Alexander J. full_name: Dear, Alexander J. last_name: Dear - first_name: Samuel I. A. full_name: Cohen, Samuel I. A. last_name: Cohen - first_name: Christopher M. full_name: Dobson, Christopher M. last_name: Dobson - first_name: Michele full_name: Vendruscolo, Michele last_name: Vendruscolo - first_name: Sara full_name: Linse, Sara last_name: Linse - first_name: Tuomas P. J. full_name: Knowles, Tuomas P. J. last_name: Knowles citation: ama: Michaels TCT, Šarić A, Curk S, et al. Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide. Nature Chemistry. 2020;12(5):445-451. doi:10.1038/s41557-020-0452-1 apa: Michaels, T. C. T., Šarić, A., Curk, S., Bernfur, K., Arosio, P., Meisl, G., … Knowles, T. P. J. (2020). Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide. Nature Chemistry. Springer Nature. https://doi.org/10.1038/s41557-020-0452-1 chicago: Michaels, Thomas C. T., Anđela Šarić, Samo Curk, Katja Bernfur, Paolo Arosio, Georg Meisl, Alexander J. Dear, et al. “Dynamics of Oligomer Populations Formed during the Aggregation of Alzheimer’s Aβ42 Peptide.” Nature Chemistry. Springer Nature, 2020. https://doi.org/10.1038/s41557-020-0452-1. ieee: T. C. T. Michaels et al., “Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide,” Nature Chemistry, vol. 12, no. 5. Springer Nature, pp. 445–451, 2020. ista: Michaels TCT, Šarić A, Curk S, Bernfur K, Arosio P, Meisl G, Dear AJ, Cohen SIA, Dobson CM, Vendruscolo M, Linse S, Knowles TPJ. 2020. Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide. Nature Chemistry. 12(5), 445–451. mla: Michaels, Thomas C. T., et al. “Dynamics of Oligomer Populations Formed during the Aggregation of Alzheimer’s Aβ42 Peptide.” Nature Chemistry, vol. 12, no. 5, Springer Nature, 2020, pp. 445–51, doi:10.1038/s41557-020-0452-1. short: T.C.T. Michaels, A. Šarić, S. Curk, K. Bernfur, P. Arosio, G. Meisl, A.J. Dear, S.I.A. Cohen, C.M. Dobson, M. Vendruscolo, S. Linse, T.P.J. Knowles, Nature Chemistry 12 (2020) 445–451. date_created: 2021-11-26T09:15:13Z date_published: 2020-04-13T00:00:00Z date_updated: 2021-11-26T11:21:08Z day: '13' doi: 10.1038/s41557-020-0452-1 extern: '1' external_id: pmid: - '32303714' intvolume: ' 12' issue: '5' keyword: - general chemical engineering - general chemistry language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2020.01.08.897488 month: '04' oa: 1 oa_version: None page: 445-451 pmid: 1 publication: Nature Chemistry publication_identifier: eissn: - 1755-4349 issn: - 1755-4330 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - relation: erratum url: https://doi.org/10.1038/s41557-020-0468-6 scopus_import: '1' status: public title: Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 12 year: '2020' ... --- _id: '10348' abstract: - lang: eng text: The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes membrane fission from within membrane necks, a process that is essential for many cellular functions, from cell division to lysosome degradation and autophagy. How it breaks membranes, though, remains unknown. Here, we characterize a sequential polymerization of ESCRT-III subunits that, driven by a recruitment cascade and by continuous subunit-turnover powered by the ATPase Vps4, induces membrane deformation and fission. During this process, the exchange of Vps24 for Did2 induces a tilt in the polymer-membrane interface, which triggers transition from flat spiral polymers to helical filament to drive the formation of membrane protrusions, and ends with the formation of a highly constricted Did2-Ist1 co-polymer that we show is competent to promote fission when bound on the inside of membrane necks. Overall, our results suggest a mechanism of stepwise changes in ESCRT-III filament structure and mechanical properties via exchange of the filament subunits to catalyze ESCRT-III activity. acknowledgement: The authors thank Nicolas Chiaruttini, Jean Gruenberg, and Lena Harker-Kirschneck for careful correction of this manuscript and helpful discussions. The authors want to thank the NCCR Chemical Biology for constant support during this project. A.R. acknowledges funding from the Swiss National Fund for Research (31003A_130520, 31003A_149975, and 31003A_173087) and the European Research Council Consolidator (311536). A.Š. acknowledges the European Research Council (802960). B.B. thanks the BBSRC (BB/K009001/1) and Wellcome Trust (203276/Z/16/Z) for support. J.M.v.F. acknowledges funding through an EMBO Long-Term Fellowship (ALTF 1065-2015), the European Commission FP7 (Marie Curie Actions, LTFCOFUND2013, and GA-2013-609409), and a Transitional Postdoc fellowship (2015/345) from the Swiss SystemsX.ch initiative, evaluated by the Swiss National Science Foundation and Swiss National Science Foundation Research (SNSF SINERGIA 160728/1 [leader, Sophie Martin]). article_processing_charge: No article_type: original author: - first_name: Anna-Katharina full_name: Pfitzner, Anna-Katharina last_name: Pfitzner - first_name: Vincent full_name: Mercier, Vincent last_name: Mercier - first_name: Xiuyun full_name: Jiang, Xiuyun last_name: Jiang - first_name: Joachim full_name: Moser von Filseck, Joachim last_name: Moser von Filseck - first_name: Buzz full_name: Baum, Buzz last_name: Baum - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Aurélien full_name: Roux, Aurélien last_name: Roux citation: ama: Pfitzner A-K, Mercier V, Jiang X, et al. An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. 2020;182(5):1140-1155.e18. doi:10.1016/j.cell.2020.07.021 apa: Pfitzner, A.-K., Mercier, V., Jiang, X., Moser von Filseck, J., Baum, B., Šarić, A., & Roux, A. (2020). An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. Elsevier. https://doi.org/10.1016/j.cell.2020.07.021 chicago: Pfitzner, Anna-Katharina, Vincent Mercier, Xiuyun Jiang, Joachim Moser von Filseck, Buzz Baum, Anđela Šarić, and Aurélien Roux. “An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission.” Cell. Elsevier, 2020. https://doi.org/10.1016/j.cell.2020.07.021. ieee: A.-K. Pfitzner et al., “An ESCRT-III polymerization sequence drives membrane deformation and fission,” Cell, vol. 182, no. 5. Elsevier, p. 1140–1155.e18, 2020. ista: Pfitzner A-K, Mercier V, Jiang X, Moser von Filseck J, Baum B, Šarić A, Roux A. 2020. An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. 182(5), 1140–1155.e18. mla: Pfitzner, Anna-Katharina, et al. “An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission.” Cell, vol. 182, no. 5, Elsevier, 2020, p. 1140–1155.e18, doi:10.1016/j.cell.2020.07.021. short: A.-K. Pfitzner, V. Mercier, X. Jiang, J. Moser von Filseck, B. Baum, A. Šarić, A. Roux, Cell 182 (2020) 1140–1155.e18. date_created: 2021-11-26T08:02:27Z date_published: 2020-08-18T00:00:00Z date_updated: 2021-11-26T08:58:37Z day: '18' doi: 10.1016/j.cell.2020.07.021 extern: '1' external_id: pmid: - '32814015' intvolume: ' 182' issue: '5' keyword: - general biochemistry - genetics and molecular biology language: - iso: eng main_file_link: - open_access: '1' url: https://www.sciencedirect.com/science/article/pii/S0092867420309296 month: '08' oa: 1 oa_version: Published Version page: 1140-1155.e18 pmid: 1 publication: Cell publication_identifier: issn: - 0092-8674 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: An ESCRT-III polymerization sequence drives membrane deformation and fission type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 182 year: '2020' ... --- _id: '10352' abstract: - lang: eng text: In the nuclear pore complex, intrinsically disordered nuclear pore proteins (FG Nups) form a selective barrier for transport into and out of the cell nucleus, in a way that remains poorly understood. The collective FG Nup behavior has long been conceptualized either as a polymer brush, dominated by entropic and excluded-volume (repulsive) interactions, or as a hydrogel, dominated by cohesive (attractive) interactions between FG Nups. Here we compare mesoscale computational simulations with a wide range of experimental data to demonstrate that FG Nups are at the crossover point between these two regimes. Specifically, we find that repulsive and attractive interactions are balanced, resulting in morphologies and dynamics that are close to those of ideal polymer chains. We demonstrate that this property of FG Nups yields sufficient cohesion to seal the transport barrier, and yet maintains fast dynamics at the molecular scale, permitting the rapid polymer rearrangements needed for transport events. acknowledgement: We thank Dino Osmanović (MIT), Roy Beck (Tel-Aviv), Larissa Kapinos (Basel), Roderick Lim (Basel), Ralf Richter (Leeds), and Anton Zilman (Toronto) for discussions. This work was funded by the Royal Society (A.Š.) and the UK Engineering and Physical Sciences Research Council (EP/L504889/1, B.W.H.). article_number: '022420' article_processing_charge: No article_type: original author: - first_name: Luke K. full_name: Davis, Luke K. last_name: Davis - first_name: Ian J. full_name: Ford, Ian J. last_name: Ford - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Bart W. full_name: Hoogenboom, Bart W. last_name: Hoogenboom citation: ama: Davis LK, Ford IJ, Šarić A, Hoogenboom BW. Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics. Physical Review E. 2020;101(2). doi:10.1103/physreve.101.022420 apa: Davis, L. K., Ford, I. J., Šarić, A., & Hoogenboom, B. W. (2020). Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics. Physical Review E. American Physical Society. https://doi.org/10.1103/physreve.101.022420 chicago: Davis, Luke K., Ian J. Ford, Anđela Šarić, and Bart W. Hoogenboom. “Intrinsically Disordered Nuclear Pore Proteins Show Ideal-Polymer Morphologies and Dynamics.” Physical Review E. American Physical Society, 2020. https://doi.org/10.1103/physreve.101.022420. ieee: L. K. Davis, I. J. Ford, A. Šarić, and B. W. Hoogenboom, “Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics,” Physical Review E, vol. 101, no. 2. American Physical Society, 2020. ista: Davis LK, Ford IJ, Šarić A, Hoogenboom BW. 2020. Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics. Physical Review E. 101(2), 022420. mla: Davis, Luke K., et al. “Intrinsically Disordered Nuclear Pore Proteins Show Ideal-Polymer Morphologies and Dynamics.” Physical Review E, vol. 101, no. 2, 022420, American Physical Society, 2020, doi:10.1103/physreve.101.022420. short: L.K. Davis, I.J. Ford, A. Šarić, B.W. Hoogenboom, Physical Review E 101 (2020). date_created: 2021-11-26T09:41:04Z date_published: 2020-02-28T00:00:00Z date_updated: 2021-11-26T11:21:16Z day: '28' doi: 10.1103/physreve.101.022420 extern: '1' external_id: pmid: - '32168597' intvolume: ' 101' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/571687 month: '02' oa: 1 oa_version: Preprint pmid: 1 publication: Physical Review E publication_identifier: eissn: - 2470-0053 issn: - 2470-0045 publication_status: published publisher: American Physical Society quality_controlled: '1' scopus_import: '1' status: public title: Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 101 year: '2020' ... --- _id: '10353' abstract: - lang: eng text: Experiments have suggested that bacterial mechanosensitive channels separate into 2D clusters, the role of which is unclear. By developing a coarse-grained computer model we find that clustering promotes the channel closure, which is highly dependent on the channel concentration and membrane stress. This behaviour yields a tightly regulated gating system, whereby at high tensions channels gate individually, and at lower tensions the channels spontaneously aggregate and inactivate. We implement this positive feedback into the model for cell volume regulation, and find that the channel clustering protects the cell against excessive loss of cytoplasmic content. acknowledgement: We thank Samantha Miller, Bert Poolman, and the members of Šarić and Pilizota laboratories for useful discussion. We acknowledge support from the Engineering and Physical Sciences Research Council (A.P. and A.Š.), the UCL Institute for the Physics of Living Systems (A.P. and A.Š.), Darwin Trust of University of Edinburgh (H.S.), Industrial Biotechnology Innovation Centre (H.S. and T.P.), BBSRC Council Crossing Biological Membrane Network (H.S. and T.P.), BBSRC/EPSRC/MRC Synthetic Biology Research Centre (T.P.), and the Royal Society (A.Š.). article_number: '048102' article_processing_charge: No article_type: original author: - first_name: Alexandru full_name: Paraschiv, Alexandru last_name: Paraschiv - first_name: Smitha full_name: Hegde, Smitha last_name: Hegde - first_name: Raman full_name: Ganti, Raman last_name: Ganti - first_name: Teuta full_name: Pilizota, Teuta last_name: Pilizota - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 citation: ama: Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. Dynamic clustering regulates activity of mechanosensitive membrane channels. Physical Review Letters. 2020;124(4). doi:10.1103/physrevlett.124.048102 apa: Paraschiv, A., Hegde, S., Ganti, R., Pilizota, T., & Šarić, A. (2020). Dynamic clustering regulates activity of mechanosensitive membrane channels. Physical Review Letters. American Physical Society. https://doi.org/10.1103/physrevlett.124.048102 chicago: Paraschiv, Alexandru, Smitha Hegde, Raman Ganti, Teuta Pilizota, and Anđela Šarić. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.” Physical Review Letters. American Physical Society, 2020. https://doi.org/10.1103/physrevlett.124.048102. ieee: A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, and A. Šarić, “Dynamic clustering regulates activity of mechanosensitive membrane channels,” Physical Review Letters, vol. 124, no. 4. American Physical Society, 2020. ista: Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. 2020. Dynamic clustering regulates activity of mechanosensitive membrane channels. Physical Review Letters. 124(4), 048102. mla: Paraschiv, Alexandru, et al. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.” Physical Review Letters, vol. 124, no. 4, 048102, American Physical Society, 2020, doi:10.1103/physrevlett.124.048102. short: A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, A. Šarić, Physical Review Letters 124 (2020). date_created: 2021-11-26T09:57:01Z date_published: 2020-01-31T00:00:00Z date_updated: 2021-11-26T11:21:12Z day: '31' doi: 10.1103/physrevlett.124.048102 extern: '1' external_id: pmid: - '32058787' intvolume: ' 124' issue: '4' keyword: - general physics and astronomy language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/553248 month: '01' oa: 1 oa_version: Preprint pmid: 1 publication: Physical Review Letters publication_identifier: eissn: - 1079-7114 issn: - 0031-9007 publication_status: published publisher: American Physical Society quality_controlled: '1' scopus_import: '1' status: public title: Dynamic clustering regulates activity of mechanosensitive membrane channels type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 124 year: '2020' ... --- _id: '10557' abstract: - lang: eng text: Data storage and retrieval systems, methods, and computer-readable media utilize a cryptographically verifiable data structure that facilitates verification of a transaction in a decentralized peer-to-peer environment using multi-hop backwards and forwards links. Backward links are cryptographic hashes of past records. Forward links are cryptographic signatures of future records that are added retroactively to records once the target block has been appended to the data structure. applicant: - Ecole Polytechnique Federale de Lausanne application_date: 2017-06-09 article_processing_charge: No author: - first_name: Bryan full_name: Ford, Bryan last_name: Ford - first_name: Linus full_name: Gasse, Linus last_name: Gasse - first_name: Eleftherios full_name: Kokoris Kogias, Eleftherios id: f5983044-d7ef-11ea-ac6d-fd1430a26d30 last_name: Kokoris Kogias - first_name: Philipp full_name: Jovanovic, Philipp last_name: Jovanovic citation: ama: Ford B, Gasse L, Kokoris Kogias E, Jovanovic P. Cryptographically verifiable data structure having multi-hop forward and backwards links and associated systems and methods. 2020. apa: Ford, B., Gasse, L., Kokoris Kogias, E., & Jovanovic, P. (2020). Cryptographically verifiable data structure having multi-hop forward and backwards links and associated systems and methods. chicago: Ford, Bryan, Linus Gasse, Eleftherios Kokoris Kogias, and Philipp Jovanovic. “Cryptographically Verifiable Data Structure Having Multi-Hop Forward and Backwards Links and Associated Systems and Methods,” 2020. ieee: B. Ford, L. Gasse, E. Kokoris Kogias, and P. Jovanovic, “Cryptographically verifiable data structure having multi-hop forward and backwards links and associated systems and methods.” 2020. ista: Ford B, Gasse L, Kokoris Kogias E, Jovanovic P. 2020. Cryptographically verifiable data structure having multi-hop forward and backwards links and associated systems and methods. mla: Ford, Bryan, et al. Cryptographically Verifiable Data Structure Having Multi-Hop Forward and Backwards Links and Associated Systems and Methods. 2020. short: B. Ford, L. Gasse, E. Kokoris Kogias, P. Jovanovic, (2020). date_created: 2021-12-16T13:28:59Z date_published: 2020-03-03T00:00:00Z date_updated: 2021-12-21T10:04:50Z day: '03' department: - _id: ElKo extern: '1' ipc: ' H04L9/3247 ; G06Q20/29 ; G06Q20/382 ; H04L9/3236' ipn: '10581613' main_file_link: - open_access: '1' url: https://patents.google.com/patent/US10581613B2/en month: '03' oa: 1 oa_version: Published Version publication_date: 2020-03-03 related_material: link: - relation: earlier_version url: https://patents.google.com/patent/US20180359096A1/en status: public title: Cryptographically verifiable data structure having multi-hop forward and backwards links and associated systems and methods type: patent user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2020' ... --- _id: '10618' abstract: - lang: eng text: Magnetism typically arises from the joint effect of Fermi statistics and repulsive Coulomb interactions, which favours ground states with non-zero electron spin. As a result, controlling spin magnetism with electric fields—a longstanding technological goal in spintronics and multiferroics1,2—can be achieved only indirectly. Here we experimentally demonstrate direct electric-field control of magnetic states in an orbital Chern insulator3,4,5,6, a magnetic system in which non-trivial band topology favours long-range order of orbital angular momentum but the spins are thought to remain disordered7,8,9,10,11,12,13,14. We use van der Waals heterostructures consisting of a graphene monolayer rotationally faulted with respect to a Bernal-stacked bilayer to realize narrow and topologically non-trivial valley-projected moiré minibands15,16,17. At fillings of one and three electrons per moiré unit cell within these bands, we observe quantized anomalous Hall effects18 with transverse resistance approximately equal to h/2e2 (where h is Planck’s constant and e is the charge on the electron), which is indicative of spontaneous polarization of the system into a single-valley-projected band with a Chern number equal to two. At a filling of three electrons per moiré unit cell, we find that the sign of the quantum anomalous Hall effect can be reversed via field-effect control of the chemical potential; moreover, this transition is hysteretic, which we use to demonstrate non-volatile electric-field-induced reversal of the magnetic state. A theoretical analysis19 indicates that the effect arises from the topological edge states, which drive a change in sign of the magnetization and thus a reversal in the favoured magnetic state. Voltage control of magnetic states can be used to electrically pattern non-volatile magnetic-domain structures hosting chiral edge states, with applications ranging from reconfigurable microwave circuit elements to ultralow-power magnetic memories. acknowledgement: We acknowledge discussions with J. Checkelsky, S. Chen, C. Dean, M. Yankowitz, D. Reilly, I. Sodemann and M. Zaletel. Work at UCSB was primarily supported by the ARO under MURI W911NF-16-1-0361. Measurements of twisted bilayer graphene (Extended Data Fig. 8) and measurements at elevated temperatures (Extended Data Fig. 3) were supported by a SEED grant and made use of shared facilities of the UCSB MRSEC (NSF DMR 1720256), a member of the Materials Research Facilities Network (www.mrfn.org). A.F.Y. acknowledges the support of the David and Lucille Packard Foundation under award 2016-65145. A.H.M. and J.Z. were supported by the National Science Foundation through the Center for Dynamics and Control of Materials, an NSF MRSEC under Cooperative Agreement number DMR-1720595, and by the Welch Foundation under grant TBF1473. C.L.T. acknowledges support from the Hertz Foundation and from the National Science Foundation Graduate Research Fellowship Program under grant 1650114. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan, Grant Number JPMXP0112101001, JSPS KAKENHI grant numbers JP20H00354 and the CREST(JPMJCR15F3), JST. article_processing_charge: No article_type: original author: - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: J. full_name: Zhu, J. last_name: Zhu - first_name: M. A. full_name: Kumar, M. A. last_name: Kumar - first_name: Y. full_name: Zhang, Y. last_name: Zhang - first_name: F. full_name: Yang, F. last_name: Yang - first_name: C. L. full_name: Tschirhart, C. L. last_name: Tschirhart - first_name: M. full_name: Serlin, M. last_name: Serlin - first_name: K. full_name: Watanabe, K. last_name: Watanabe - first_name: T. full_name: Taniguchi, T. last_name: Taniguchi - first_name: A. H. full_name: MacDonald, A. H. last_name: MacDonald - first_name: A. F. full_name: Young, A. F. last_name: Young citation: ama: Polshyn H, Zhu J, Kumar MA, et al. Electrical switching of magnetic order in an orbital Chern insulator. Nature. 2020;588(7836):66-70. doi:10.1038/s41586-020-2963-8 apa: Polshyn, H., Zhu, J., Kumar, M. A., Zhang, Y., Yang, F., Tschirhart, C. L., … Young, A. F. (2020). Electrical switching of magnetic order in an orbital Chern insulator. Nature. Springer Nature. https://doi.org/10.1038/s41586-020-2963-8 chicago: Polshyn, Hryhoriy, J. Zhu, M. A. Kumar, Y. Zhang, F. Yang, C. L. Tschirhart, M. Serlin, et al. “Electrical Switching of Magnetic Order in an Orbital Chern Insulator.” Nature. Springer Nature, 2020. https://doi.org/10.1038/s41586-020-2963-8. ieee: H. Polshyn et al., “Electrical switching of magnetic order in an orbital Chern insulator,” Nature, vol. 588, no. 7836. Springer Nature, pp. 66–70, 2020. ista: Polshyn H, Zhu J, Kumar MA, Zhang Y, Yang F, Tschirhart CL, Serlin M, Watanabe K, Taniguchi T, MacDonald AH, Young AF. 2020. Electrical switching of magnetic order in an orbital Chern insulator. Nature. 588(7836), 66–70. mla: Polshyn, Hryhoriy, et al. “Electrical Switching of Magnetic Order in an Orbital Chern Insulator.” Nature, vol. 588, no. 7836, Springer Nature, 2020, pp. 66–70, doi:10.1038/s41586-020-2963-8. short: H. Polshyn, J. Zhu, M.A. Kumar, Y. Zhang, F. Yang, C.L. Tschirhart, M. Serlin, K. Watanabe, T. Taniguchi, A.H. MacDonald, A.F. Young, Nature 588 (2020) 66–70. date_created: 2022-01-13T14:12:17Z date_published: 2020-11-23T00:00:00Z date_updated: 2022-01-13T14:21:04Z day: '23' doi: 10.1038/s41586-020-2963-8 extern: '1' external_id: arxiv: - '2004.11353' pmid: - '33230333' intvolume: ' 588' issue: '7836' keyword: - multidisciplinary language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2004.11353 month: '11' oa: 1 oa_version: Preprint page: 66-70 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Electrical switching of magnetic order in an orbital Chern insulator type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 588 year: '2020' ... --- _id: '10650' abstract: - lang: eng text: The understanding of material systems with strong electron-electron interactions is the central problem in modern condensed matter physics. Despite this, the essential physics of many of these materials is still not understood and we have no overall perspective on their properties. Moreover, we have very little ability to make predictions in this class of systems. In this manuscript we share our personal views of what the major open problems are in correlated electron systems and we discuss some possible routes to make progress in this rich and fascinating field. This manuscript is the result of the vigorous discussions and deliberations that took place at Johns Hopkins University during a three-day workshop January 27, 28, and 29, 2020 that brought together six senior scientists and 46 more junior scientists. Our hope, is that the topics we have presented will provide inspiration for others working in this field and motivation for the idea that significant progress can be made on very hard problems if we focus our collective energies. acknowledgement: "We thank NSF CMP program for suggestions regarding the topic and general structure of the workshop. This project was supported by the NSF DMR-2002329 and The Gordon and Betty Moore Foundation (GBMF) EPiQS initiative. We would like to sincerely thank A. Kapitulnik, A. J. Leggett, M.B. Maple, T.M. McQueen, M. Norman, P. S. Riseborough, and G. A. Sawatzky for their lectures at the workshop and advice on the writing of this manuscript. We would also like to thank G. Blumberg, C. Broholm, S. Crooker, N. Drichko, and A. Patel for helpful consultation on topics discussed\r\nherein. A number of individuals also had independent support: (AA, EH; GBMF-4305), (IMH; GBMF-9071), (HJC; NHMFL is supported by the NSF DMR-1644779 and the state of Florida), (YH, AZ; Miller Institute for Basic Research in Science), (YC; US DOE-BES DEAC02-06CH11357), (AS; Spallation Neutron Source, a DOE Office of Science User Facility operated by ORNL), (SAAG; ARO-W911NF-18-1-0290, NSF DMR-1455233), (YW; DOE-BES DE-SC0019331, GBMF-4532)." article_processing_charge: No author: - first_name: A full_name: Alexandradinata, A last_name: Alexandradinata - first_name: N.P. full_name: Armitage, N.P. last_name: Armitage - first_name: Andrey full_name: Baydin, Andrey last_name: Baydin - first_name: Wenli full_name: Bi, Wenli last_name: Bi - first_name: Yue full_name: Cao, Yue last_name: Cao - first_name: Hitesh J. full_name: Changlani, Hitesh J. last_name: Changlani - first_name: Eli full_name: Chertkov, Eli last_name: Chertkov - first_name: Eduardo H. full_name: da Silva Neto, Eduardo H. last_name: da Silva Neto - first_name: Luca full_name: Delacretaz, Luca last_name: Delacretaz - first_name: Ismail full_name: El Baggari, Ismail last_name: El Baggari - first_name: G.M. full_name: Ferguson, G.M. last_name: Ferguson - first_name: William J. full_name: Gannon, William J. last_name: Gannon - first_name: Sayed Ali Akbar full_name: Ghorashi, Sayed Ali Akbar last_name: Ghorashi - first_name: Berit H. full_name: Goodge, Berit H. last_name: Goodge - first_name: Olga full_name: Goulko, Olga last_name: Goulko - first_name: G. full_name: Grissonnache, G. last_name: Grissonnache - first_name: Alannah full_name: Hallas, Alannah last_name: Hallas - first_name: Ian M. full_name: Hayes, Ian M. last_name: Hayes - first_name: Yu full_name: He, Yu last_name: He - first_name: Edwin W. full_name: Huang, Edwin W. last_name: Huang - first_name: Anshu full_name: Kogar, Anshu last_name: Kogar - first_name: Divine full_name: Kumah, Divine last_name: Kumah - first_name: Jong Yeon full_name: Lee, Jong Yeon last_name: Lee - first_name: A. full_name: Legros, A. last_name: Legros - first_name: Fahad full_name: Mahmood, Fahad last_name: Mahmood - first_name: Yulia full_name: Maximenko, Yulia last_name: Maximenko - first_name: Nick full_name: Pellatz, Nick last_name: Pellatz - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: Tarapada full_name: Sarkar, Tarapada last_name: Sarkar - first_name: Allen full_name: Scheie, Allen last_name: Scheie - first_name: Kyle L. full_name: Seyler, Kyle L. last_name: Seyler - first_name: Zhenzhong full_name: Shi, Zhenzhong last_name: Shi - first_name: Brian full_name: Skinner, Brian last_name: Skinner - first_name: Lucia full_name: Steinke, Lucia last_name: Steinke - first_name: K. full_name: Thirunavukkuarasu, K. last_name: Thirunavukkuarasu - first_name: Thaís Victa full_name: Trevisan, Thaís Victa last_name: Trevisan - first_name: Michael full_name: Vogl, Michael last_name: Vogl - first_name: Pavel A. full_name: Volkov, Pavel A. last_name: Volkov - first_name: Yao full_name: Wang, Yao last_name: Wang - first_name: Yishu full_name: Wang, Yishu last_name: Wang - first_name: Di full_name: Wei, Di last_name: Wei - first_name: Kaya full_name: Wei, Kaya last_name: Wei - first_name: Shuolong full_name: Yang, Shuolong last_name: Yang - first_name: Xian full_name: Zhang, Xian last_name: Zhang - first_name: Ya-Hui full_name: Zhang, Ya-Hui last_name: Zhang - first_name: Liuyan full_name: Zhao, Liuyan last_name: Zhao - first_name: Alfred full_name: Zong, Alfred last_name: Zong citation: ama: Alexandradinata A, Armitage NP, Baydin A, et al. The future of the correlated electron problem. arXiv. apa: Alexandradinata, A., Armitage, N. P., Baydin, A., Bi, W., Cao, Y., Changlani, H. J., … Zong, A. (n.d.). The future of the correlated electron problem. arXiv. chicago: Alexandradinata, A, N.P. Armitage, Andrey Baydin, Wenli Bi, Yue Cao, Hitesh J. Changlani, Eli Chertkov, et al. “The Future of the Correlated Electron Problem.” ArXiv, n.d. ieee: A. Alexandradinata et al., “The future of the correlated electron problem,” arXiv. . ista: Alexandradinata A, Armitage NP, Baydin A, Bi W, Cao Y, Changlani HJ, Chertkov E, da Silva Neto EH, Delacretaz L, El Baggari I, Ferguson GM, Gannon WJ, Ghorashi SAA, Goodge BH, Goulko O, Grissonnache G, Hallas A, Hayes IM, He Y, Huang EW, Kogar A, Kumah D, Lee JY, Legros A, Mahmood F, Maximenko Y, Pellatz N, Polshyn H, Sarkar T, Scheie A, Seyler KL, Shi Z, Skinner B, Steinke L, Thirunavukkuarasu K, Trevisan TV, Vogl M, Volkov PA, Wang Y, Wang Y, Wei D, Wei K, Yang S, Zhang X, Zhang Y-H, Zhao L, Zong A. The future of the correlated electron problem. arXiv, . mla: Alexandradinata, A., et al. “The Future of the Correlated Electron Problem.” ArXiv. short: A. Alexandradinata, N.P. Armitage, A. Baydin, W. Bi, Y. Cao, H.J. Changlani, E. Chertkov, E.H. da Silva Neto, L. Delacretaz, I. El Baggari, G.M. Ferguson, W.J. Gannon, S.A.A. Ghorashi, B.H. Goodge, O. Goulko, G. Grissonnache, A. Hallas, I.M. Hayes, Y. He, E.W. Huang, A. Kogar, D. Kumah, J.Y. Lee, A. Legros, F. Mahmood, Y. Maximenko, N. Pellatz, H. Polshyn, T. Sarkar, A. Scheie, K.L. Seyler, Z. Shi, B. Skinner, L. Steinke, K. Thirunavukkuarasu, T.V. Trevisan, M. Vogl, P.A. Volkov, Y. Wang, Y. Wang, D. Wei, K. Wei, S. Yang, X. Zhang, Y.-H. Zhang, L. Zhao, A. Zong, ArXiv (n.d.). date_created: 2022-01-20T10:55:36Z date_published: 2020-10-01T00:00:00Z date_updated: 2022-01-24T08:05:51Z day: '01' extern: '1' external_id: arxiv: - '2010.00584' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2010.00584 month: '10' oa: 1 oa_version: Preprint page: '55' publication: arXiv publication_status: submitted status: public title: The future of the correlated electron problem type: preprint user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2020' ... --- _id: '10673' abstract: - lang: eng text: We propose a neural information processing system obtained by re-purposing the function of a biological neural circuit model to govern simulated and real-world control tasks. Inspired by the structure of the nervous system of the soil-worm, C. elegans, we introduce ordinary neural circuits (ONCs), defined as the model of biological neural circuits reparameterized for the control of alternative tasks. We first demonstrate that ONCs realize networks with higher maximum flow compared to arbitrary wired networks. We then learn instances of ONCs to control a series of robotic tasks, including the autonomous parking of a real-world rover robot. For reconfiguration of the purpose of the neural circuit, we adopt a search-based optimization algorithm. Ordinary neural circuits perform on par and, in some cases, significantly surpass the performance of contemporary deep learning models. ONC networks are compact, 77% sparser than their counterpart neural controllers, and their neural dynamics are fully interpretable at the cell-level. acknowledgement: "RH and RG are partially supported by Horizon-2020 ECSEL Project grant No. 783163 (iDev40), Productive 4.0, and ATBMBFW CPS-IoT Ecosystem. ML was supported in part by the Austrian Science Fund (FWF) under grant Z211-N23\r\n(Wittgenstein Award). AA is supported by the National Science Foundation (NSF) Graduate Research Fellowship\r\nProgram. RH and DR are partially supported by The Boeing Company and JP Morgan Chase. This research work is\r\npartially drawn from the PhD dissertation of RH.\r\n" alternative_title: - PMLR article_processing_charge: No author: - first_name: Ramin full_name: Hasani, Ramin last_name: Hasani - first_name: Mathias full_name: Lechner, Mathias id: 3DC22916-F248-11E8-B48F-1D18A9856A87 last_name: Lechner - first_name: Alexander full_name: Amini, Alexander last_name: Amini - first_name: Daniela full_name: Rus, Daniela last_name: Rus - first_name: Radu full_name: Grosu, Radu last_name: Grosu citation: ama: 'Hasani R, Lechner M, Amini A, Rus D, Grosu R. A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits. In: Proceedings of the 37th International Conference on Machine Learning. PMLR. ; 2020:4082-4093.' apa: 'Hasani, R., Lechner, M., Amini, A., Rus, D., & Grosu, R. (2020). A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits. In Proceedings of the 37th International Conference on Machine Learning (pp. 4082–4093). Virtual.' chicago: 'Hasani, Ramin, Mathias Lechner, Alexander Amini, Daniela Rus, and Radu Grosu. “A Natural Lottery Ticket Winner: Reinforcement Learning with Ordinary Neural Circuits.” In Proceedings of the 37th International Conference on Machine Learning, 4082–93. PMLR, 2020.' ieee: 'R. Hasani, M. Lechner, A. Amini, D. Rus, and R. Grosu, “A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits,” in Proceedings of the 37th International Conference on Machine Learning, Virtual, 2020, pp. 4082–4093.' ista: 'Hasani R, Lechner M, Amini A, Rus D, Grosu R. 2020. A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits. Proceedings of the 37th International Conference on Machine Learning. ML: Machine LearningPMLR, PMLR, , 4082–4093.' mla: 'Hasani, Ramin, et al. “A Natural Lottery Ticket Winner: Reinforcement Learning with Ordinary Neural Circuits.” Proceedings of the 37th International Conference on Machine Learning, 2020, pp. 4082–93.' short: R. Hasani, M. Lechner, A. Amini, D. Rus, R. Grosu, in:, Proceedings of the 37th International Conference on Machine Learning, 2020, pp. 4082–4093. conference: end_date: 2020-07-18 location: Virtual name: 'ML: Machine Learning' start_date: 2020-07-12 date_created: 2022-01-25T15:50:34Z date_published: 2020-01-01T00:00:00Z date_updated: 2022-01-26T11:14:27Z ddc: - '000' department: - _id: GradSch - _id: ToHe file: - access_level: open_access checksum: c9a4a29161777fc1a89ef451c040e3b1 content_type: application/pdf creator: cchlebak date_created: 2022-01-26T11:08:51Z date_updated: 2022-01-26T11:08:51Z file_id: '10691' file_name: 2020_PMLR_Hasani.pdf file_size: 2329798 relation: main_file success: 1 file_date_updated: 2022-01-26T11:08:51Z has_accepted_license: '1' language: - iso: eng license: https://creativecommons.org/licenses/by-nc-nd/3.0/ main_file_link: - open_access: '1' url: http://proceedings.mlr.press/v119/hasani20a.html oa: 1 oa_version: Published Version page: 4082-4093 project: - _id: 25F42A32-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z211 name: The Wittgenstein Prize publication: Proceedings of the 37th International Conference on Machine Learning publication_identifier: issn: - 2640-3498 publication_status: published quality_controlled: '1' scopus_import: '1' series_title: PMLR status: public title: 'A natural lottery ticket winner: Reinforcement learning with ordinary neural circuits' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) short: CC BY-NC-ND (3.0) type: conference user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2020' ... --- _id: '10693' abstract: - lang: eng text: High quality graphene heterostructures host an array of fractional quantum Hall isospin ferromagnets with diverse spin and valley orders. While a variety of phase transitions have been observed, disentangling the isospin phase diagram of these states is hampered by the absence of direct probes of spin and valley order. I will describe nonlocal transport measurements based on launching spin waves from a gate defined lateral heterojunction, performed in ultra-clean Corbino geometry graphene devices. At high magnetic fields, we find that the spin-wave transport signal is detected in all FQH states between ν = 0 and 1; however, between ν = 1 and 2 only odd numerator FQH states show finite nonlocal transport, despite the identical ground state spin polarizations in odd- and even numerator states. The results reveal that the neutral spin-waves are both spin and sublattice polarized making them a sensitive probe of ground state sublattice structure. Armed with this understanding, we use nonlocal transport signal to a magnetic field tuned isospin phase transition, showing that the emergent even denominator state at ν = 1/2 in monolayer graphene is indeed a multicomponent state featuring equal populations on each sublattice. alternative_title: - Bulletin of the American Physical Society article_number: B54. 00007 article_processing_charge: No author: - first_name: Haoxin full_name: Zhou, Haoxin last_name: Zhou - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: Takashi full_name: Tanaguchi, Takashi last_name: Tanaguchi - first_name: Kenji full_name: Watanabe, Kenji last_name: Watanabe - first_name: Andrea full_name: Young, Andrea last_name: Young citation: ama: 'Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order. In: APS March Meeting 2020. Vol 65. American Physical Society; 2020.' apa: 'Zhou, H., Polshyn, H., Tanaguchi, T., Watanabe, K., & Young, A. (2020). Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order. In APS March Meeting 2020 (Vol. 65). Denver, CO, United States: American Physical Society.' chicago: Zhou, Haoxin, Hryhoriy Polshyn, Takashi Tanaguchi, Kenji Watanabe, and Andrea Young. “Sublattice Resolved Spin Wave Transport through Graphene Fractional Quantum Hall States as a Probe of Isospin Order.” In APS March Meeting 2020, Vol. 65. American Physical Society, 2020. ieee: H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, and A. Young, “Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order,” in APS March Meeting 2020, Denver, CO, United States, 2020, vol. 65, no. 1. ista: 'Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. 2020. Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B54. 00007.' mla: Zhou, Haoxin, et al. “Sublattice Resolved Spin Wave Transport through Graphene Fractional Quantum Hall States as a Probe of Isospin Order.” APS March Meeting 2020, vol. 65, no. 1, B54. 00007, American Physical Society, 2020. short: H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020. conference: end_date: 2020-03-06 location: Denver, CO, United States name: 'APS: American Physical Society' start_date: 2020-03-02 date_created: 2022-01-27T10:50:10Z date_published: 2020-03-01T00:00:00Z date_updated: 2022-01-27T10:58:38Z day: '01' extern: '1' intvolume: ' 65' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://meetings.aps.org/Meeting/MAR20/Session/B54.7 month: '03' oa: 1 oa_version: Published Version publication: APS March Meeting 2020 publication_identifier: issn: - 0003-0503 publication_status: published publisher: American Physical Society quality_controlled: '1' status: public title: Sublattice resolved spin wave transport through graphene fractional quantum Hall states as a probe of isospin order type: conference user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 65 year: '2020' ... --- _id: '10698' abstract: - lang: eng text: This is the second of three talks describing the observation and characterization of a ferromagnetic moiré heterostructure based on twisted bilayer graphene aligned to hexagonal boron nitride. I will compare the qualitative and quantitative features of this observed quantum anomalous Hall state to traditional systems engineered from thin film (Bi,Sb)2Te3 topological insulators. In particular, we find that the measured electronic energy gap of ~30K is several times higher than the Curie temperature, consistent with a lack of disorder associated with magnetic dopants. In this system, the quantization arises from spontaneous ferromagnetic polarization into a single spin and valley moiré subband, which is topological despite the lack of spin orbit coupling. I will also discuss the observation of current induced switching, which allows the magnetic state of the heterostructure to be controllably reversed with currents as small as a few nanoamperes. acknowledgement: I would like to thank the MURI Program, AFOSR, Sloan Foundation, and the ARO for their generous support of this work. alternative_title: - Bulletin of the American Physical Society article_number: B59.00011 article_processing_charge: No author: - first_name: Marec full_name: Serlin, Marec last_name: Serlin - first_name: Charles full_name: Tschirhart, Charles last_name: Tschirhart - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: Yuxuan full_name: Zhang, Yuxuan last_name: Zhang - first_name: Jiacheng full_name: Zhu, Jiacheng last_name: Zhu - first_name: Martin E. full_name: Huber, Martin E. last_name: Huber - first_name: Leon full_name: Balents, Leon last_name: Balents - first_name: Kenji full_name: Watanabe, Kenji last_name: Watanabe - first_name: Takashi full_name: Tanaguchi, Takashi last_name: Tanaguchi - first_name: Andrea full_name: Young, Andrea last_name: Young citation: ama: 'Serlin M, Tschirhart C, Polshyn H, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching. In: APS March Meeting 2020. Vol 65. American Physical Society; 2020.' apa: 'Serlin, M., Tschirhart, C., Polshyn, H., Zhang, Y., Zhu, J., Huber, M. E., … Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching. In APS March Meeting 2020 (Vol. 65). Denver, CO, United States: American Physical Society.' chicago: 'Serlin, Marec, Charles Tschirhart, Hryhoriy Polshyn, Yuxuan Zhang, Jiacheng Zhu, Martin E. Huber, Leon Balents, Kenji Watanabe, Takashi Tanaguchi, and Andrea Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part II: Temperature Dependence and Current Switching.” In APS March Meeting 2020, Vol. 65. American Physical Society, 2020.' ieee: 'M. Serlin et al., “Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching,” in APS March Meeting 2020, Denver, CO, United States, 2020, vol. 65, no. 1.' ista: 'Serlin M, Tschirhart C, Polshyn H, Zhang Y, Zhu J, Huber ME, Balents L, Watanabe K, Tanaguchi T, Young A. 2020. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B59.00011.' mla: 'Serlin, Marec, et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part II: Temperature Dependence and Current Switching.” APS March Meeting 2020, vol. 65, no. 1, B59.00011, American Physical Society, 2020.' short: M. Serlin, C. Tschirhart, H. Polshyn, Y. Zhang, J. Zhu, M.E. Huber, L. Balents, K. Watanabe, T. Tanaguchi, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020. conference: end_date: 2020-03-06 location: Denver, CO, United States name: 'APS: American Physical Society' start_date: 2020-03-02 date_created: 2022-01-28T10:46:57Z date_published: 2020-03-01T00:00:00Z date_updated: 2023-02-21T15:57:52Z day: '01' extern: '1' external_id: arxiv: - '1907.00261' intvolume: ' 65' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://meetings.aps.org/Meeting/MAR20/Session/B59.11 month: '03' oa: 1 oa_version: Published Version publication: APS March Meeting 2020 publication_status: published publisher: American Physical Society quality_controlled: '1' related_material: record: - id: '10619' relation: other status: public status: public title: 'Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part II: Temperature dependence and current switching' type: conference user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 65 year: '2020' ... --- _id: '10699' abstract: - lang: eng text: This is the third of three talks describing the observation and characterization of a ferromagnetic moiré heterostructure based on twisted bilayer graphene aligned to hexagonal boron nitride. In this segment I will present scanning probe magnetometry data acquired using a nanoSQUID-on-tip microscope, which provides ~150 nm spatial resolution and a field sensitivity of ~10 nT/rtHz. We study the distribution of magnetic domains within the device as a function of density, magnetic field training, and DC current. Our data allow us to constrain the magnitude of the orbital magnetic moment of the electrons in the QAH state. Comparison with simultaneously acquired transport data allows us to precisely correlate single domain dynamics with discrete jumps in the observed anomalous Hall signal. acknowledgement: I would like to thank the MURI program, Sloan foundation, AFOSR, and ARO for their generous support of this work. I would also like to thank the NSF GRFP and the Hertz foundation for their generous support of my graduate studies. alternative_title: - Bulletin of the American Physical Society article_number: B59.00013 article_processing_charge: No author: - first_name: Charles full_name: Tschirhart, Charles last_name: Tschirhart - first_name: Marec full_name: Serlin, Marec last_name: Serlin - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: Yuxuan full_name: Zhang, Yuxuan last_name: Zhang - first_name: Jiacheng full_name: Zhu, Jiacheng last_name: Zhu - first_name: Leon full_name: Balents, Leon last_name: Balents - first_name: Martin E. full_name: Huber, Martin E. last_name: Huber - first_name: Kenji full_name: Watanabe, Kenji last_name: Watanabe - first_name: Takashi full_name: Tanaguchi, Takashi last_name: Tanaguchi - first_name: Andrea full_name: Young, Andrea last_name: Young citation: ama: 'Tschirhart C, Serlin M, Polshyn H, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry. In: APS March Meeting 2020. Vol 65. American Physical Society; 2020.' apa: 'Tschirhart, C., Serlin, M., Polshyn, H., Zhang, Y., Zhu, J., Balents, L., … Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry. In APS March Meeting 2020 (Vol. 65). Denver, CO, United States: American Physical Society.' chicago: 'Tschirhart, Charles, Marec Serlin, Hryhoriy Polshyn, Yuxuan Zhang, Jiacheng Zhu, Leon Balents, Martin E. Huber, Kenji Watanabe, Takashi Tanaguchi, and Andrea Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part III: Scanning Probe Magnetometry.” In APS March Meeting 2020, Vol. 65. American Physical Society, 2020.' ieee: 'C. Tschirhart et al., “Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry,” in APS March Meeting 2020, Denver, CO, United States, 2020, vol. 65, no. 1.' ista: 'Tschirhart C, Serlin M, Polshyn H, Zhang Y, Zhu J, Balents L, Huber ME, Watanabe K, Tanaguchi T, Young A. 2020. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B59.00013.' mla: 'Tschirhart, Charles, et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part III: Scanning Probe Magnetometry.” APS March Meeting 2020, vol. 65, no. 1, B59.00013, American Physical Society, 2020.' short: C. Tschirhart, M. Serlin, H. Polshyn, Y. Zhang, J. Zhu, L. Balents, M.E. Huber, K. Watanabe, T. Tanaguchi, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020. conference: end_date: 2020-03-06 location: Denver, CO, United States name: 'APS: American Physical Society' start_date: 2020-03-02 date_created: 2022-01-28T10:57:49Z date_published: 2020-03-01T00:00:00Z date_updated: 2023-02-21T15:57:52Z day: '01' extern: '1' external_id: arxiv: - '1907.00261' intvolume: ' 65' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://meetings.aps.org/Meeting/MAR20/Session/B59.13 month: '03' oa: 1 oa_version: Published Version publication: APS March Meeting 2020 publication_identifier: issn: - 0003-0503 publication_status: published publisher: American Physical Society quality_controlled: '1' related_material: record: - id: '10619' relation: other status: public status: public title: 'Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part III: Scanning probe magnetometry' type: conference user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 65 year: '2020' ... --- _id: '10697' abstract: - lang: eng text: We report the observation of a quantized anomalous Hall effect in a moiré heterostructure consisting of twisted bilayer graphene aligned to an encapsulating hBN substrate. The effect occurs at a density of 3 electrons per superlattice unit cell, where we observe magnetic hysteresis and a Hall resistance quantized to within 0.1% of the resistance quantum at temperatures as high as 3K. In this first of 3 talks, I will describe the fabrication procedure for our device as well as basic transport characterization measurements. I will introduce the phenomenology of twisted bilayer graphene and present evidence for hBN alignment as manifested in the hierarchy of symmetry-breaking gaps and anomalous magnetoresistance. acknowledgement: I would like to thank the MURI program, Sloan foundation, AFOSR, and ARO for their generous support of this work. alternative_title: - Bulletin of the American Physical Society article_number: B59.00012 article_processing_charge: No author: - first_name: Yuxuan full_name: Zhang, Yuxuan last_name: Zhang - first_name: Marec full_name: Serlin, Marec last_name: Serlin - first_name: Charles full_name: Tschirhart, Charles last_name: Tschirhart - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: Jiacheng full_name: Zhu, Jiacheng last_name: Zhu - first_name: Leon full_name: Balents, Leon last_name: Balents - first_name: Martin E. full_name: Huber, Martin E. last_name: Huber - first_name: Takashi full_name: Taniguchi, Takashi last_name: Taniguchi - first_name: Kenji full_name: Watanabe, Kenji last_name: Watanabe - first_name: Andrea full_name: Young, Andrea last_name: Young citation: ama: 'Zhang Y, Serlin M, Tschirhart C, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport. In: APS March Meeting 2020. Vol 65. American Physical Society; 2020.' apa: 'Zhang, Y., Serlin, M., Tschirhart, C., Polshyn, H., Zhu, J., Balents, L., … Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport. In APS March Meeting 2020 (Vol. 65). Denver, CO, United States: American Physical Society.' chicago: 'Zhang, Yuxuan, Marec Serlin, Charles Tschirhart, Hryhoriy Polshyn, Jiacheng Zhu, Leon Balents, Martin E. Huber, Takashi Taniguchi, Kenji Watanabe, and Andrea Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part I: Device Fabrication and Transport.” In APS March Meeting 2020, Vol. 65. American Physical Society, 2020.' ieee: 'Y. Zhang et al., “Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport,” in APS March Meeting 2020, Denver, CO, United States, 2020, vol. 65, no. 1.' ista: 'Zhang Y, Serlin M, Tschirhart C, Polshyn H, Zhu J, Balents L, Huber ME, Taniguchi T, Watanabe K, Young A. 2020. Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B59.00012.' mla: 'Zhang, Yuxuan, et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure, Part I: Device Fabrication and Transport.” APS March Meeting 2020, vol. 65, no. 1, B59.00012, American Physical Society, 2020.' short: Y. Zhang, M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, L. Balents, M.E. Huber, T. Taniguchi, K. Watanabe, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020. conference: end_date: 2020-03-06 location: Denver, CO, United States name: 'APS: American Physical Society' start_date: 2020-03-02 date_created: 2022-01-28T10:28:35Z date_published: 2020-03-01T00:00:00Z date_updated: 2023-02-21T15:57:52Z day: '01' extern: '1' external_id: arxiv: - '1907.00261' intvolume: ' 65' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://meetings.aps.org/Meeting/MAR20/Session/B59.12 month: '03' oa: 1 oa_version: Published Version publication: APS March Meeting 2020 publication_status: published publisher: American Physical Society quality_controlled: '1' related_material: record: - id: '10619' relation: other status: public status: public title: 'Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part I: Device fabrication and transport' type: conference user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 65 year: '2020' ... --- _id: '10696' abstract: - lang: eng text: We experimentally investigate twisted van der Waals heterostructures of monolayer graphene rotated with respect to a bernal stacked graphene bilayer. We report transport measurements for devices with twist angles between 0.9 and 1.4°. The electric field allows efficient tuning of the width, isolation and the topology of the moiré bands in this system. By comparing magnetoresistance measurements to numerical simulations, we develop an understanding of the band structure. Finally, we observe correlated states at half- and quarter-fillings, which arise when narrow moire sublattice band is isolated by energy gaps from dispersive bands. We investigate the effects of in-plane and out-of-plane magnetic field on these states and discuss the implication for their spin- and valley- polarization. alternative_title: - Bulletin of the American Physical Society article_number: B51.00005 article_processing_charge: No author: - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: Jihang full_name: Zhu, Jihang last_name: Zhu - first_name: Manish full_name: Kumar, Manish last_name: Kumar - first_name: Takashi full_name: Taniguchi, Takashi last_name: Taniguchi - first_name: Kenji full_name: Watanabe, Kenji last_name: Watanabe - first_name: Allan full_name: MacDonald, Allan last_name: MacDonald - first_name: Andrea full_name: Young, Andrea last_name: Young citation: ama: 'Polshyn H, Zhu J, Kumar M, et al. Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures. In: APS March Meeting 2020. Vol 65. American Physical Society; 2020.' apa: 'Polshyn, H., Zhu, J., Kumar, M., Taniguchi, T., Watanabe, K., MacDonald, A., & Young, A. (2020). Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures. In APS March Meeting 2020 (Vol. 65). Denver, CO, United States: American Physical Society.' chicago: Polshyn, Hryhoriy, Jihang Zhu, Manish Kumar, Takashi Taniguchi, Kenji Watanabe, Allan MacDonald, and Andrea Young. “Correlated States and Tunable Topological Bands in Twisted Monolayer-Bilayer Graphene Heterostructures.” In APS March Meeting 2020, Vol. 65. American Physical Society, 2020. ieee: H. Polshyn et al., “Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures,” in APS March Meeting 2020, Denver, CO, United States, 2020, vol. 65, no. 1. ista: 'Polshyn H, Zhu J, Kumar M, Taniguchi T, Watanabe K, MacDonald A, Young A. 2020. Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures. APS March Meeting 2020. APS: American Physical Society, Bulletin of the American Physical Society, vol. 65, B51.00005.' mla: Polshyn, Hryhoriy, et al. “Correlated States and Tunable Topological Bands in Twisted Monolayer-Bilayer Graphene Heterostructures.” APS March Meeting 2020, vol. 65, no. 1, B51.00005, American Physical Society, 2020. short: H. Polshyn, J. Zhu, M. Kumar, T. Taniguchi, K. Watanabe, A. MacDonald, A. Young, in:, APS March Meeting 2020, American Physical Society, 2020. conference: end_date: 2020-03-06 location: Denver, CO, United States name: 'APS: American Physical Society' start_date: 2020-03-02 date_created: 2022-01-28T10:09:19Z date_published: 2020-03-01T00:00:00Z date_updated: 2022-02-08T10:22:08Z day: '01' extern: '1' intvolume: ' 65' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://meetings.aps.org/Meeting/MAR20/Session/B51.5 month: '03' oa: 1 oa_version: Published Version publication: APS March Meeting 2020 publication_identifier: issn: - 0003-0503 publication_status: published publisher: American Physical Society quality_controlled: '1' status: public title: Correlated states and tunable topological bands in twisted monolayer-bilayer graphene heterostructures type: conference user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 65 year: '2020' ... --- _id: '10701' abstract: - lang: eng text: Partially filled Landau levels host competing electronic orders. For example, electron solids may prevail close to integer filling of the Landau levels before giving way to fractional quantum Hall liquids at higher carrier density1,2. Here, we report the observation of an electron solid with non-collinear spin texture in monolayer graphene, consistent with solidification of skyrmions3—topological spin textures characterized by quantized electrical charge4,5. We probe the spin texture of the solids using a modified Corbino geometry that allows ferromagnetic magnons to be launched and detected6,7. We find that magnon transport is highly efficient when one Landau level is filled (ν=1), consistent with quantum Hall ferromagnetic spin polarization. However, even minimal doping immediately quenches the magnon signal while leaving the vanishing low-temperature charge conductivity unchanged. Our results can be understood by the formation of a solid of charged skyrmions near ν=1, whose non-collinear spin texture leads to rapid magnon decay. Data near fractional fillings show evidence of several fractional skyrmion solids, suggesting that graphene hosts a highly tunable landscape of coupled spin and charge orders. acknowledgement: We acknowledge discussions with B. Halperin, C. Huang, A. Macdonald and M. Zalatel. Experimental work at UCSB was supported by the Army Research Office under awards nos. MURI W911NF-16-1-0361 and W911NF-16-1-0482. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by MEXT (Japan) and CREST (JPMJCR15F3), JST. A.F.Y. acknowledges the support of the David and Lucile Packard Foundation and and Alfred. P. Sloan Foundation. article_processing_charge: No article_type: original author: - first_name: Haoxin full_name: Zhou, Haoxin last_name: Zhou - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: Takashi full_name: Taniguchi, Takashi last_name: Taniguchi - first_name: Kenji full_name: Watanabe, Kenji last_name: Watanabe - first_name: Andrea F. full_name: Young, Andrea F. last_name: Young citation: ama: Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. Skyrmion solids in monolayer graphene. Nature Physics. 2020;16(2):154-158. doi:10.1038/s41567-019-0729-8 apa: Zhou, H., Polshyn, H., Taniguchi, T., Watanabe, K., & Young, A. F. (2020). Skyrmion solids in monolayer graphene. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-019-0729-8 chicago: Zhou, Haoxin, Hryhoriy Polshyn, Takashi Taniguchi, Kenji Watanabe, and Andrea F. Young. “Skyrmion Solids in Monolayer Graphene.” Nature Physics. Springer Nature, 2020. https://doi.org/10.1038/s41567-019-0729-8. ieee: H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young, “Skyrmion solids in monolayer graphene,” Nature Physics, vol. 16, no. 2. Springer Nature, pp. 154–158, 2020. ista: Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. 2020. Skyrmion solids in monolayer graphene. Nature Physics. 16(2), 154–158. mla: Zhou, Haoxin, et al. “Skyrmion Solids in Monolayer Graphene.” Nature Physics, vol. 16, no. 2, Springer Nature, 2020, pp. 154–58, doi:10.1038/s41567-019-0729-8. short: H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, A.F. Young, Nature Physics 16 (2020) 154–158. date_created: 2022-01-28T12:04:09Z date_published: 2020-02-01T00:00:00Z date_updated: 2022-01-31T07:10:07Z day: '01' doi: 10.1038/s41567-019-0729-8 extern: '1' external_id: arxiv: - '1904.11485' intvolume: ' 16' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1904.11485 month: '02' oa: 1 oa_version: Preprint page: 154-158 publication: Nature Physics publication_identifier: eissn: - 1745-2481 issn: - 1745-2473 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: Skyrmion solids in monolayer graphene type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 16 year: '2020' ... --- _id: '11056' abstract: - lang: eng text: Aging of the circulatory system correlates with the pathogenesis of a large spectrum of diseases. However, it is largely unknown which factors drive the age-dependent or pathological decline of the vasculature and how vascular defects relate to tissue aging. The goal of the study is to design a multianalytical approach to identify how the cellular microenvironment (i.e., fibroblasts) and serum from healthy donors of different ages or Alzheimer disease (AD) patients can modulate the functionality of organ-specific vascular endothelial cells (VECs). Long-living human microvascular networks embedding VECs and fibroblasts from skin biopsies are generated. RNA-seq, secretome analyses, and microfluidic assays demonstrate that fibroblasts from young donors restore the functionality of aged endothelial cells, an effect also achieved by serum from young donors. New biomarkers of vascular aging are validated in human biopsies and it is shown that young serum induces angiopoietin-like-4, which can restore compromised vascular barriers. This strategy is then employed to characterize transcriptional/functional changes induced on the blood–brain barrier by AD serum, demonstrating the importance of PTP4A3 in the regulation of permeability. Features of vascular degeneration during aging and AD are recapitulated, and a tool to identify novel biomarkers that can be exploited to develop future therapeutics modulating vascular function is established. article_number: '2000044' article_processing_charge: No article_type: original author: - first_name: Simone full_name: Bersini, Simone last_name: Bersini - first_name: Rafael full_name: Arrojo e Drigo, Rafael last_name: Arrojo e Drigo - first_name: Ling full_name: Huang, Ling last_name: Huang - first_name: Maxim N. full_name: Shokhirev, Maxim N. last_name: Shokhirev - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. Advanced Biosystems. 2020;4(5). doi:10.1002/adbi.202000044 apa: Bersini, S., Arrojo e Drigo, R., Huang, L., Shokhirev, M. N., & Hetzer, M. (2020). Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. Advanced Biosystems. Wiley. https://doi.org/10.1002/adbi.202000044 chicago: Bersini, Simone, Rafael Arrojo e Drigo, Ling Huang, Maxim N. Shokhirev, and Martin Hetzer. “Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.” Advanced Biosystems. Wiley, 2020. https://doi.org/10.1002/adbi.202000044. ieee: S. Bersini, R. Arrojo e Drigo, L. Huang, M. N. Shokhirev, and M. Hetzer, “Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease,” Advanced Biosystems, vol. 4, no. 5. Wiley, 2020. ista: Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. 2020. Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. Advanced Biosystems. 4(5), 2000044. mla: Bersini, Simone, et al. “Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.” Advanced Biosystems, vol. 4, no. 5, 2000044, Wiley, 2020, doi:10.1002/adbi.202000044. short: S. Bersini, R. Arrojo e Drigo, L. Huang, M.N. Shokhirev, M. Hetzer, Advanced Biosystems 4 (2020). date_created: 2022-04-07T07:43:57Z date_published: 2020-05-01T00:00:00Z date_updated: 2022-07-18T08:30:48Z day: '01' ddc: - '570' doi: 10.1002/adbi.202000044 extern: '1' external_id: pmid: - '32402127' file: - access_level: open_access checksum: 5584d9a1609812dc75c02ce1e35d2ec0 content_type: application/pdf creator: dernst date_created: 2022-04-08T07:06:05Z date_updated: 2022-04-08T07:06:05Z file_id: '11134' file_name: 2020_AdvancedBiosystems_Bersini.pdf file_size: 2490829 relation: main_file success: 1 file_date_updated: 2022-04-08T07:06:05Z has_accepted_license: '1' intvolume: ' 4' issue: '5' keyword: - General Biochemistry - Genetics and Molecular Biology - Biomedical Engineering - Biomaterials language: - iso: eng month: '05' oa: 1 oa_version: Published Version pmid: 1 publication: Advanced Biosystems publication_identifier: issn: - 2366-7478 - 2366-7478 publication_status: published publisher: Wiley quality_controlled: '1' scopus_import: '1' status: public title: Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 4 year: '2020' ... --- _id: '11055' abstract: - lang: eng text: Vascular dysfunctions are a common feature of multiple age-related diseases. However, modeling healthy and pathological aging of the human vasculature represents an unresolved experimental challenge. Here, we generated induced vascular endothelial cells (iVECs) and smooth muscle cells (iSMCs) by direct reprogramming of healthy human fibroblasts from donors of different ages and Hutchinson-Gilford Progeria Syndrome (HGPS) patients. iVECs induced from old donors revealed upregulation of GSTM1 and PALD1, genes linked to oxidative stress, inflammation and endothelial junction stability, as vascular aging markers. A functional assay performed on PALD1 KD VECs demonstrated a recovery in vascular permeability. We found that iSMCs from HGPS donors overexpressed bone morphogenetic protein (BMP)−4, which plays a key role in both vascular calcification and endothelial barrier damage observed in HGPS. Strikingly, BMP4 concentrations are higher in serum from HGPS vs. age-matched mice. Furthermore, targeting BMP4 with blocking antibody recovered the functionality of the vascular barrier in vitro, hence representing a potential future therapeutic strategy to limit cardiovascular dysfunction in HGPS. These results show that iVECs and iSMCs retain disease-related signatures, allowing modeling of vascular aging and HGPS in vitro. article_number: e54383 article_processing_charge: No article_type: original author: - first_name: Simone full_name: Bersini, Simone last_name: Bersini - first_name: Roberta full_name: Schulte, Roberta last_name: Schulte - first_name: Ling full_name: Huang, Ling last_name: Huang - first_name: Hannah full_name: Tsai, Hannah last_name: Tsai - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. eLife. 2020;9. doi:10.7554/elife.54383 apa: Bersini, S., Schulte, R., Huang, L., Tsai, H., & Hetzer, M. (2020). Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.54383 chicago: Bersini, Simone, Roberta Schulte, Ling Huang, Hannah Tsai, and Martin Hetzer. “Direct Reprogramming of Human Smooth Muscle and Vascular Endothelial Cells Reveals Defects Associated with Aging and Hutchinson-Gilford Progeria Syndrome.” ELife. eLife Sciences Publications, 2020. https://doi.org/10.7554/elife.54383. ieee: S. Bersini, R. Schulte, L. Huang, H. Tsai, and M. Hetzer, “Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome,” eLife, vol. 9. eLife Sciences Publications, 2020. ista: Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. 2020. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. eLife. 9, e54383. mla: Bersini, Simone, et al. “Direct Reprogramming of Human Smooth Muscle and Vascular Endothelial Cells Reveals Defects Associated with Aging and Hutchinson-Gilford Progeria Syndrome.” ELife, vol. 9, e54383, eLife Sciences Publications, 2020, doi:10.7554/elife.54383. short: S. Bersini, R. Schulte, L. Huang, H. Tsai, M. Hetzer, ELife 9 (2020). date_created: 2022-04-07T07:43:48Z date_published: 2020-09-08T00:00:00Z date_updated: 2022-07-18T08:30:37Z day: '08' ddc: - '570' doi: 10.7554/elife.54383 extern: '1' external_id: pmid: - '32896271' file: - access_level: open_access checksum: f8b3821349a194050be02570d8fe7d4b content_type: application/pdf creator: dernst date_created: 2022-04-08T06:53:10Z date_updated: 2022-04-08T06:53:10Z file_id: '11132' file_name: 2020_eLife_Bersini.pdf file_size: 4399825 relation: main_file success: 1 file_date_updated: 2022-04-08T06:53:10Z has_accepted_license: '1' intvolume: ' 9' keyword: - General Immunology and Microbiology - General Biochemistry - Genetics and Molecular Biology - General Medicine - General Neuroscience language: - iso: eng month: '09' oa: 1 oa_version: Published Version pmid: 1 publication: eLife publication_identifier: issn: - 2050-084X publication_status: published publisher: eLife Sciences Publications quality_controlled: '1' scopus_import: '1' status: public title: Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 9 year: '2020' ... --- _id: '11054' abstract: - lang: eng text: In recent years, the nuclear pore complex (NPC) has emerged as a key player in genome regulation and cellular homeostasis. New discoveries have revealed that the NPC has multiple cellular functions besides mediating the molecular exchange between the nucleus and the cytoplasm. In this review, we discuss non-transport aspects of the NPC focusing on the NPC-genome interaction, the extreme longevity of the NPC proteins, and NPC dysfunction in age-related diseases. The examples summarized herein demonstrate that the NPC, which first evolved to enable the biochemical communication between the nucleus and the cytoplasm, now doubles as the gatekeeper of cellular identity and aging. article_processing_charge: No article_type: review author: - first_name: Ukrae H. full_name: Cho, Ukrae H. last_name: Cho - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: 'Cho UH, Hetzer M. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. 2020;106(6):899-911. doi:10.1016/j.neuron.2020.05.031' apa: 'Cho, U. H., & Hetzer, M. (2020). Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.05.031' chicago: 'Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.05.031.' ieee: 'U. H. Cho and M. Hetzer, “Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging,” Neuron, vol. 106, no. 6. Elsevier, pp. 899–911, 2020.' ista: 'Cho UH, Hetzer M. 2020. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. 106(6), 899–911.' mla: 'Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging.” Neuron, vol. 106, no. 6, Elsevier, 2020, pp. 899–911, doi:10.1016/j.neuron.2020.05.031.' short: U.H. Cho, M. Hetzer, Neuron 106 (2020) 899–911. date_created: 2022-04-07T07:43:36Z date_published: 2020-06-17T00:00:00Z date_updated: 2022-07-18T08:29:35Z day: '17' doi: 10.1016/j.neuron.2020.05.031 extern: '1' external_id: pmid: - '32553207' intvolume: ' 106' issue: '6' keyword: - General Neuroscience language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.neuron.2020.05.031 month: '06' oa: 1 oa_version: Published Version page: 899-911 pmid: 1 publication: Neuron publication_identifier: issn: - 0896-6273 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: 'Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging' type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 106 year: '2020' ... --- _id: '11057' abstract: - lang: eng text: During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated during nuclear reformation in anaphase/telophase. Many aspects of the underlying principles that mediate transcriptional memory and reactivation in the daughter cells remain unclear. Here, we used ChIP-seq on synchronized cells at different stages after mitosis to generate genome-wide maps of histone modifications. Combined with EU-RNA-seq and Hi-C analyses, we found that during prometaphase, promoters, enhancers, and insulators retain H3K4me3 and H3K4me1, while losing H3K27ac. Enhancers globally retaining mitotic H3K4me1 or locally retaining mitotic H3K27ac are associated with cell type-specific genes and their transcription factors for rapid transcriptional activation. As cells exit mitosis, promoters regain H3K27ac, which correlates with transcriptional reactivation. Insulators also gain H3K27ac and CCCTC-binding factor (CTCF) in anaphase/telophase. This increase of H3K27ac in anaphase/telophase is required for posttranscriptional activation and may play a role in the establishment of topologically associating domains (TADs). Together, our results suggest that the genome is reorganized in a sequential order, in which histone methylations occur first in prometaphase, histone acetylation, and CTCF in anaphase/telophase, transcription in cytokinesis, and long-range chromatin interactions in early G1. We thus provide insights into the histone modification landscape that allows faithful reestablishment of the transcriptional program and TADs during cell division. article_processing_charge: No article_type: original author: - first_name: Hyeseon full_name: Kang, Hyeseon last_name: Kang - first_name: Maxim N. full_name: Shokhirev, Maxim N. last_name: Shokhirev - first_name: Zhichao full_name: Xu, Zhichao last_name: Xu - first_name: Sahaana full_name: Chandran, Sahaana last_name: Chandran - first_name: Jesse R. full_name: Dixon, Jesse R. last_name: Dixon - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes & Development. 2020;34(13-14):913-930. doi:10.1101/gad.335794.119 apa: Kang, H., Shokhirev, M. N., Xu, Z., Chandran, S., Dixon, J. R., & Hetzer, M. (2020). Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes & Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.335794.119 chicago: Kang, Hyeseon, Maxim N. Shokhirev, Zhichao Xu, Sahaana Chandran, Jesse R. Dixon, and Martin Hetzer. “Dynamic Regulation of Histone Modifications and Long-Range Chromosomal Interactions during Postmitotic Transcriptional Reactivation.” Genes & Development. Cold Spring Harbor Laboratory Press, 2020. https://doi.org/10.1101/gad.335794.119. ieee: H. Kang, M. N. Shokhirev, Z. Xu, S. Chandran, J. R. Dixon, and M. Hetzer, “Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation,” Genes & Development, vol. 34, no. 13–14. Cold Spring Harbor Laboratory Press, pp. 913–930, 2020. ista: Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. 2020. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes & Development. 34(13–14), 913–930. mla: Kang, Hyeseon, et al. “Dynamic Regulation of Histone Modifications and Long-Range Chromosomal Interactions during Postmitotic Transcriptional Reactivation.” Genes & Development, vol. 34, no. 13–14, Cold Spring Harbor Laboratory Press, 2020, pp. 913–30, doi:10.1101/gad.335794.119. short: H. Kang, M.N. Shokhirev, Z. Xu, S. Chandran, J.R. Dixon, M. Hetzer, Genes & Development 34 (2020) 913–930. date_created: 2022-04-07T07:44:09Z date_published: 2020-04-28T00:00:00Z date_updated: 2022-07-18T08:31:08Z day: '28' ddc: - '570' doi: 10.1101/gad.335794.119 extern: '1' external_id: pmid: - '32499403' file: - access_level: open_access checksum: 84e92d40e67936c739628315c238daf9 content_type: application/pdf creator: dernst date_created: 2022-04-08T07:12:33Z date_updated: 2022-04-08T07:12:33Z file_id: '11136' file_name: 2020_GenesDevelopment_Kang.pdf file_size: 4406772 relation: main_file success: 1 file_date_updated: 2022-04-08T07:12:33Z has_accepted_license: '1' intvolume: ' 34' issue: 13-14 keyword: - Developmental Biology - Genetics language: - iso: eng month: '04' oa: 1 oa_version: Published Version page: 913-930 pmid: 1 publication: Genes & Development publication_identifier: issn: - 0890-9369 - 1549-5477 publication_status: published publisher: Cold Spring Harbor Laboratory Press quality_controlled: '1' scopus_import: '1' status: public title: Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 34 year: '2020' ... --- _id: '11058' abstract: - lang: eng text: Nucleoporin 93 (Nup93) expression inversely correlates with the survival of triple-negative breast cancer patients. However, our knowledge of Nup93 function in breast cancer besides its role as structural component of the nuclear pore complex is not understood. Combination of functional assays and genetic analyses suggested that chromatin interaction of Nup93 partially modulates the expression of genes associated with actin cytoskeleton remodeling and epithelial to mesenchymal transition, resulting in impaired invasion of triple-negative, claudin-low breast cancer cells. Nup93 depletion induced stress fiber formation associated with reduced cell migration/proliferation and impaired expression of mesenchymal-like genes. Silencing LIMCH1, a gene responsible for actin cytoskeleton remodeling and up-regulated upon Nup93 depletion, partially restored the invasive phenotype of cancer cells. Loss of Nup93 led to significant defects in tumor establishment/propagation in vivo, whereas patient samples revealed that high Nup93 and low LIMCH1 expression correlate with late tumor stage. Our approach identified Nup93 as contributor of triple-negative, claudin-low breast cancer cell invasion and paves the way to study the role of nuclear envelope proteins during breast cancer tumorigenesis. article_number: e201900623 article_processing_charge: No article_type: original author: - first_name: Simone full_name: Bersini, Simone last_name: Bersini - first_name: Nikki K full_name: Lytle, Nikki K last_name: Lytle - first_name: Roberta full_name: Schulte, Roberta last_name: Schulte - first_name: Ling full_name: Huang, Ling last_name: Huang - first_name: Geoffrey M full_name: Wahl, Geoffrey M last_name: Wahl - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Science Alliance. 2020;3(1). doi:10.26508/lsa.201900623 apa: Bersini, S., Lytle, N. K., Schulte, R., Huang, L., Wahl, G. M., & Hetzer, M. (2020). Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Science Alliance. Life Science Alliance. https://doi.org/10.26508/lsa.201900623 chicago: Bersini, Simone, Nikki K Lytle, Roberta Schulte, Ling Huang, Geoffrey M Wahl, and Martin Hetzer. “Nup93 Regulates Breast Tumor Growth by Modulating Cell Proliferation and Actin Cytoskeleton Remodeling.” Life Science Alliance. Life Science Alliance, 2020. https://doi.org/10.26508/lsa.201900623. ieee: S. Bersini, N. K. Lytle, R. Schulte, L. Huang, G. M. Wahl, and M. Hetzer, “Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling,” Life Science Alliance, vol. 3, no. 1. Life Science Alliance, 2020. ista: Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. 2020. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Science Alliance. 3(1), e201900623. mla: Bersini, Simone, et al. “Nup93 Regulates Breast Tumor Growth by Modulating Cell Proliferation and Actin Cytoskeleton Remodeling.” Life Science Alliance, vol. 3, no. 1, e201900623, Life Science Alliance, 2020, doi:10.26508/lsa.201900623. short: S. Bersini, N.K. Lytle, R. Schulte, L. Huang, G.M. Wahl, M. Hetzer, Life Science Alliance 3 (2020). date_created: 2022-04-07T07:44:18Z date_published: 2020-01-01T00:00:00Z date_updated: 2022-07-18T08:31:20Z day: '01' ddc: - '570' doi: 10.26508/lsa.201900623 extern: '1' external_id: pmid: - '31959624' file: - access_level: open_access checksum: 3bf33e7e93bef7823287807206b69b38 content_type: application/pdf creator: dernst date_created: 2022-04-08T07:33:01Z date_updated: 2022-04-08T07:33:01Z file_id: '11137' file_name: 2020_LifeScienceAlliance_Bersini.pdf file_size: 2653960 relation: main_file success: 1 file_date_updated: 2022-04-08T07:33:01Z has_accepted_license: '1' intvolume: ' 3' issue: '1' keyword: - Health - Toxicology and Mutagenesis - Plant Science - Biochemistry - Genetics and Molecular Biology (miscellaneous) - Ecology language: - iso: eng month: '01' oa: 1 oa_version: Published Version pmid: 1 publication: Life Science Alliance publication_identifier: issn: - 2575-1077 publication_status: published publisher: Life Science Alliance quality_controlled: '1' scopus_import: '1' status: public title: Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 3 year: '2020' ... --- _id: '11503' abstract: - lang: eng text: "Context. The Lyα emitter (LAE) fraction, XLAE, is a potentially powerful probe of the evolution of the intergalactic neutral hydrogen gas fraction. However, uncertainties in the measurement of XLAE are still under debate.\r\nAims. Thanks to deep data obtained with the integral field spectrograph Multi Unit Spectroscopic Explorer (MUSE), we can measure the evolution of the LAE fraction homogeneously over a wide redshift range of z ≈ 3–6 for UV-faint galaxies (down to UV magnitudes of M1500 ≈ −17.75). This is a significantly fainter range than in former studies (M1500 ≤ −18.75) and it allows us to probe the bulk of the population of high-redshift star-forming galaxies.\r\nMethods. We constructed a UV-complete photometric-redshift sample following UV luminosity functions and measured the Lyα emission with MUSE using the latest (second) data release from the MUSE Hubble Ultra Deep Field Survey.\r\nResults. We derived the redshift evolution of XLAE for M1500 ∈ [ − 21.75; −17.75] for the first time with a equivalent width range EW(Lyα) ≥ 65 Å and found low values of XLAE ≲ 30% at z ≲ 6. The best-fit linear relation is XLAE = 0.07+0.06−0.03z − 0.22+0.12−0.24. For M1500 ∈ [ − 20.25; −18.75] and EW(Lyα) ≥ 25 Å, our XLAE values are consistent with those in the literature within 1σ at z ≲ 5, but our median values are systematically lower than reported values over the whole redshift range. In addition, we do not find a significant dependence of XLAE on M1500 for EW(Lyα) ≥ 50 Å at z ≈ 3–4, in contrast with previous work. The differences in XLAE mainly arise from selection biases for Lyman Break Galaxies (LBGs) in the literature: UV-faint LBGs are more easily selected if they have strong Lyα emission, hence XLAE is biased towards higher values when those samples are used.\r\nConclusions. Our results suggest either a lower increase of XLAE towards z ≈ 6 than previously suggested, or even a turnover of XLAE at z ≈ 5.5, which may be the signature of a late or patchy reionization process. We compared our results with predictions from a cosmological galaxy evolution model. We find that a model with a bursty star formation (SF) can reproduce our observed LAE fractions much better than models where SF is a smooth function of time." acknowledgement: We thank the anonymous referee for constructive comments and suggestions. We would like to express our gratitude to Stephane De Barros and Pablo Arrabal Haro for kindly providing their data plotted in Figs. 1, 2, and 8. We are grateful to Kazuhiro Shimasaku, Masami Ouchi, Rieko Momose, Daniel Schaerer, Hidenobu Yajima, Taku Okamura, Makoto Ando, and Hinako Goto for giving insightful comments and suggestions. This work is based on observations taken by VLT, which is operated by European Southern Observatory. This research made use of Astropy (http://www.astropy.org), which is a community-developed core Python package for Astronomy (Astropy Collaboration 2013, 2018), MARZ, MPDAF, and matplotlib (Hunter 2007). H.K. acknowledges support from Japan Society for the Promotion of Science (JSPS) through the JSPS Research Fellowship for Young Scientists and Overseas Challenge Program for Young Researchers. AV acknowledges support from the ERC starting grant 757258-TRIPLE and the SNF Professorship 176808-TRIPLE. This work was supported by the project FOGHAR (Agence Nationale de la Recherche, ANR-13-BS05-0010-02). JB acknowledges support from the ORAGE project from the Agence Nationale de la Recherche under grant ANR-14-CE33-0016-03. JR acknowledges support from the ERC starting grant 336736-CALENDS. T. H. acknowledges supports by the Grant-inAid for Scientic Research 19J01620. article_number: A12 article_processing_charge: No article_type: original author: - first_name: Haruka full_name: Kusakabe, Haruka last_name: Kusakabe - first_name: Jérémy full_name: Blaizot, Jérémy last_name: Blaizot - first_name: Thibault full_name: Garel, Thibault last_name: Garel - first_name: Anne full_name: Verhamme, Anne last_name: Verhamme - first_name: Roland full_name: Bacon, Roland last_name: Bacon - first_name: Johan full_name: Richard, Johan last_name: Richard - first_name: Takuya full_name: Hashimoto, Takuya last_name: Hashimoto - first_name: Hanae full_name: Inami, Hanae last_name: Inami - first_name: Simon full_name: Conseil, Simon last_name: Conseil - first_name: Bruno full_name: Guiderdoni, Bruno last_name: Guiderdoni - first_name: Alyssa B. full_name: Drake, Alyssa B. last_name: Drake - first_name: Edmund full_name: Christian Herenz, Edmund last_name: Christian Herenz - first_name: Joop full_name: Schaye, Joop last_name: Schaye - first_name: Pascal full_name: Oesch, Pascal last_name: Oesch - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Raffaella full_name: Anna Marino, Raffaella last_name: Anna Marino - first_name: Kasper full_name: Borello Schmidt, Kasper last_name: Borello Schmidt - first_name: Roser full_name: Pelló, Roser last_name: Pelló - first_name: Michael full_name: Maseda, Michael last_name: Maseda - first_name: Floriane full_name: Leclercq, Floriane last_name: Leclercq - first_name: Josephine full_name: Kerutt, Josephine last_name: Kerutt - first_name: Guillaume full_name: Mahler, Guillaume last_name: Mahler citation: ama: 'Kusakabe H, Blaizot J, Garel T, et al. The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of the Lyα emitter fraction from z = 3 to z = 6. Astronomy & Astrophysics. 2020;638. doi:10.1051/0004-6361/201937340' apa: 'Kusakabe, H., Blaizot, J., Garel, T., Verhamme, A., Bacon, R., Richard, J., … Mahler, G. (2020). The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of the Lyα emitter fraction from z = 3 to z = 6. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/201937340' chicago: 'Kusakabe, Haruka, Jérémy Blaizot, Thibault Garel, Anne Verhamme, Roland Bacon, Johan Richard, Takuya Hashimoto, et al. “The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of the Lyα Emitter Fraction from z = 3 to z = 6.” Astronomy & Astrophysics. EDP Sciences, 2020. https://doi.org/10.1051/0004-6361/201937340.' ieee: 'H. Kusakabe et al., “The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of the Lyα emitter fraction from z = 3 to z = 6,” Astronomy & Astrophysics, vol. 638. EDP Sciences, 2020.' ista: 'Kusakabe H, Blaizot J, Garel T, Verhamme A, Bacon R, Richard J, Hashimoto T, Inami H, Conseil S, Guiderdoni B, Drake AB, Christian Herenz E, Schaye J, Oesch P, Matthee JJ, Anna Marino R, Borello Schmidt K, Pelló R, Maseda M, Leclercq F, Kerutt J, Mahler G. 2020. The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of the Lyα emitter fraction from z = 3 to z = 6. Astronomy & Astrophysics. 638, A12.' mla: 'Kusakabe, Haruka, et al. “The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of the Lyα Emitter Fraction from z = 3 to z = 6.” Astronomy & Astrophysics, vol. 638, A12, EDP Sciences, 2020, doi:10.1051/0004-6361/201937340.' short: H. Kusakabe, J. Blaizot, T. Garel, A. Verhamme, R. Bacon, J. Richard, T. Hashimoto, H. Inami, S. Conseil, B. Guiderdoni, A.B. Drake, E. Christian Herenz, J. Schaye, P. Oesch, J.J. Matthee, R. Anna Marino, K. Borello Schmidt, R. Pelló, M. Maseda, F. Leclercq, J. Kerutt, G. Mahler, Astronomy & Astrophysics 638 (2020). date_created: 2022-07-06T09:50:48Z date_published: 2020-06-03T00:00:00Z date_updated: 2022-07-19T09:35:20Z day: '03' doi: 10.1051/0004-6361/201937340 extern: '1' external_id: arxiv: - '2003.12083' intvolume: ' 638' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'dark ages / reionization / first stars / early Universe / cosmology: observations / galaxies: evolution / galaxies: high-redshift / intergalactic medium' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2003.12083 month: '06' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' scopus_import: '1' status: public title: 'The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of the Lyα emitter fraction from z = 3 to z = 6' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 638 year: '2020' ... --- _id: '11504' abstract: - lang: eng text: We present spatially resolved maps of six individually-detected Lyman α haloes (LAHs) as well as a first statistical analysis of the Lyman α (Lyα) spectral signature in the circum-galactic medium of high-redshift star-forming galaxies (−17.5 >  MUV >  −21.5) using the Multi-Unit Spectroscopic Explorer. Our resolved spectroscopic analysis of the LAHs reveals significant intrahalo variations of the Lyα line profile. Using a three-dimensional two-component model for the Lyα emission, we measured the full width at half maximum (FWHM), the peak velocity shift, and the asymmetry of the Lyα line in the core and in the halo of 19 galaxies. We find that the Lyα line shape is statistically different in the halo compared to the core (in terms of width, peak wavelength, and asymmetry) for ≈40% of our galaxies. Similarly to object-by-object based studies and a recent resolved study using lensing, we find a correlation between the peak velocity shift and the width of the Lyα line both at the interstellar and circum-galactic scales. This trend has been predicted by radiative transfer simulations of galactic winds as a result of resonant scattering in outflows. While there is a lack of correlation between the spectral properties and the spatial scale lengths of our LAHs, we find a correlation between the width of the line in the LAH and the halo flux fraction. Interestingly, UV bright galaxies (MUV <  −20) show broader, more redshifted, and less asymmetric Lyα lines in their haloes. The most significant correlation found is for the FWHM of the line and the UV continuum slope of the galaxy, suggesting that the redder galaxies have broader Lyα lines. The generally broad and red line shapes found in the halo component suggest that the Lyα haloes are powered either by scattering processes through an outflowing medium, fluorescent emission from outflowing cold clumps of gas, or a mix of both. Considering the large diversity of the Lyα line profiles observed in our sample and the lack of strong correlation, the interpretation of our results is still broadly open and underlines the need for realistic spatially resolved models of the LAHs. acknowledgement: F.L., R.B., and S.C. acknowledge support from the ERC advanced grant 339659-MUSICOS. F.L., T.G., H.K., and A.V. acknowledge support from the ERC starting grant ERC-757258-TRIPLE. A.C. and J.R. acknowledge support from the ERC starting grant 336736-CALENDS. J.B. acknowledges support by FCT/MCTES through national funds (PID-DAC) by grant UID/FIS/04434/2019 and through Investigador FCT Contract No.IF/01654/2014/CP1215/CT0003. T.H. was supported by Leading Initiative for Excellent Young Researchers, MEXT, Japan. article_number: A82 article_processing_charge: No article_type: original author: - first_name: Floriane full_name: Leclercq, Floriane last_name: Leclercq - first_name: Roland full_name: Bacon, Roland last_name: Bacon - first_name: Anne full_name: Verhamme, Anne last_name: Verhamme - first_name: Thibault full_name: Garel, Thibault last_name: Garel - first_name: Jérémy full_name: Blaizot, Jérémy last_name: Blaizot - first_name: Jarle full_name: Brinchmann, Jarle last_name: Brinchmann - first_name: Sebastiano full_name: Cantalupo, Sebastiano last_name: Cantalupo - first_name: Adélaïde full_name: Claeyssens, Adélaïde last_name: Claeyssens - first_name: Simon full_name: Conseil, Simon last_name: Conseil - first_name: Thierry full_name: Contini, Thierry last_name: Contini - first_name: Takuya full_name: Hashimoto, Takuya last_name: Hashimoto - first_name: Edmund Christian full_name: Herenz, Edmund Christian last_name: Herenz - first_name: Haruka full_name: Kusakabe, Haruka last_name: Kusakabe - first_name: Raffaella Anna full_name: Marino, Raffaella Anna last_name: Marino - first_name: Michael full_name: Maseda, Michael last_name: Maseda - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Peter full_name: Mitchell, Peter last_name: Mitchell - first_name: Gabriele full_name: Pezzulli, Gabriele last_name: Pezzulli - first_name: Johan full_name: Richard, Johan last_name: Richard - first_name: Kasper Borello full_name: Schmidt, Kasper Borello last_name: Schmidt - first_name: Lutz full_name: Wisotzki, Lutz last_name: Wisotzki citation: ama: 'Leclercq F, Bacon R, Verhamme A, et al. The MUSE Hubble Ultra Deep field survey: XIII. Spatially resolved spectral properties of Lyman α haloes around star-forming galaxies at z > 3. Astronomy & Astrophysics. 2020;635. doi:10.1051/0004-6361/201937339' apa: 'Leclercq, F., Bacon, R., Verhamme, A., Garel, T., Blaizot, J., Brinchmann, J., … Wisotzki, L. (2020). The MUSE Hubble Ultra Deep field survey: XIII. Spatially resolved spectral properties of Lyman α haloes around star-forming galaxies at z > 3. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/201937339' chicago: 'Leclercq, Floriane, Roland Bacon, Anne Verhamme, Thibault Garel, Jérémy Blaizot, Jarle Brinchmann, Sebastiano Cantalupo, et al. “The MUSE Hubble Ultra Deep Field Survey: XIII. Spatially Resolved Spectral Properties of Lyman α Haloes around Star-Forming Galaxies at z > 3.” Astronomy & Astrophysics. EDP Sciences, 2020. https://doi.org/10.1051/0004-6361/201937339.' ieee: 'F. Leclercq et al., “The MUSE Hubble Ultra Deep field survey: XIII. Spatially resolved spectral properties of Lyman α haloes around star-forming galaxies at z > 3,” Astronomy & Astrophysics, vol. 635. EDP Sciences, 2020.' ista: 'Leclercq F, Bacon R, Verhamme A, Garel T, Blaizot J, Brinchmann J, Cantalupo S, Claeyssens A, Conseil S, Contini T, Hashimoto T, Herenz EC, Kusakabe H, Marino RA, Maseda M, Matthee JJ, Mitchell P, Pezzulli G, Richard J, Schmidt KB, Wisotzki L. 2020. The MUSE Hubble Ultra Deep field survey: XIII. Spatially resolved spectral properties of Lyman α haloes around star-forming galaxies at z > 3. Astronomy & Astrophysics. 635, A82.' mla: 'Leclercq, Floriane, et al. “The MUSE Hubble Ultra Deep Field Survey: XIII. Spatially Resolved Spectral Properties of Lyman α Haloes around Star-Forming Galaxies at z > 3.” Astronomy & Astrophysics, vol. 635, A82, EDP Sciences, 2020, doi:10.1051/0004-6361/201937339.' short: F. Leclercq, R. Bacon, A. Verhamme, T. Garel, J. Blaizot, J. Brinchmann, S. Cantalupo, A. Claeyssens, S. Conseil, T. Contini, T. Hashimoto, E.C. Herenz, H. Kusakabe, R.A. Marino, M. Maseda, J.J. Matthee, P. Mitchell, G. Pezzulli, J. Richard, K.B. Schmidt, L. Wisotzki, Astronomy & Astrophysics 635 (2020). date_created: 2022-07-06T09:56:20Z date_published: 2020-03-11T00:00:00Z date_updated: 2022-07-19T09:36:58Z day: '11' doi: 10.1051/0004-6361/201937339 extern: '1' external_id: arxiv: - '2002.05731' intvolume: ' 635' keyword: - Space and Planetary Science - 'Astronomy and Astrophysics galaxies: high-redshift / galaxies: formation / galaxies: evolution / cosmology: observations' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2002.05731 month: '03' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' scopus_import: '1' status: public title: 'The MUSE Hubble Ultra Deep field survey: XIII. Spatially resolved spectral properties of Lyman α haloes around star-forming galaxies at z > 3' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 635 year: '2020' ... --- _id: '11501' abstract: - lang: eng text: We investigated the ultraviolet (UV) spectral properties of faint Lyman-α emitters (LAEs) in the redshift range 2.9 ≤ z ≤ 4.6, and we provide material to prepare future observations of the faint Universe. We used data from the MUSE Hubble Ultra Deep Survey to construct mean rest-frame spectra of continuum-faint (median MUV of −18 and down to MUV of −16), low stellar mass (median value of 108.4 M⊙ and down to 107 M⊙) LAEs at redshift z ≳ 3. We computed various averaged spectra of LAEs, subsampled on the basis of their observational (e.g., Lyα strength, UV magnitude and spectral slope) and physical (e.g., stellar mass and star-formation rate) properties. We searched for UV spectral features other than Lyα, such as higher ionization nebular emission lines and absorption features. We successfully observed the O III]λ1666 and [C III]λ1907+C III]λ1909 collisionally excited emission lines and the He IIλ1640 recombination feature, as well as the resonant C IVλλ1548,1551 doublet either in emission or P-Cygni. We compared the observed spectral properties of the different mean spectra and find the emission lines to vary with the observational and physical properties of the LAEs. In particular, the mean spectra of LAEs with larger Lyα equivalent widths, fainter UV magnitudes, bluer UV spectral slopes, and lower stellar masses show the strongest nebular emission. The line ratios of these lines are similar to those measured in the spectra of local metal-poor galaxies, while their equivalent widths are weaker compared to the handful of extreme values detected in individual spectra of z >  2 galaxies. This suggests that weak UV features are likely ubiquitous in high z, low-mass, and faint LAEs. We publicly released the stacked spectra, as they can serve as empirical templates for the design of future observations, such as those with the James Webb Space Telescope and the Extremely Large Telescope. acknowledgement: 'We thank Margherita Talia, Stéphane Charlot, Adele Plat and Alba Vidal-García for helpful discussions. This work is supported by the ERC advanced grant 339659-MUSICOS (R. Bacon). AF acknowledges the support from grant PRIN MIUR 2017 20173ML3WW. MVM and JP would like to thank the Leiden/ESA Astrophysics Program for Summer Students (LEAPS) for funding at the outset of this project. FL, HK, and AV acknowledge support from the ERC starting grant ERC-757258-TRIPLE. TH was supported by Leading Initiative for Excellent Young Researchers, MEXT, Japan. JB acknowledges support by FCT/MCTES through national funds by the grant UID/FIS/04434/2019, UIDB/04434/2020 and UIDP/04434/2020 and through the Investigador FCT Contract No. IF/01654/2014/CP1215/CT0003. HI acknowledges support from JSPS KAKENHI Grant Number JP19K23462. We would also like to thank the organizers and participants of the Leiden Lorentz Center workshop: Revolutionary Spectroscopy of Today as a Springboard to Webb. This work made use of several open source python packages: NUMPY (van der Walt et al. 2011), MATPLOTLIB (Hunter 2007), ASTROPY (Astropy Collaboration 2013) and MPDAF (MUSE Python Data Analysis Framework, Piqueras et al. 2019).' article_number: A118 article_processing_charge: No article_type: original author: - first_name: Anna full_name: Feltre, Anna last_name: Feltre - first_name: Michael V. full_name: Maseda, Michael V. last_name: Maseda - first_name: Roland full_name: Bacon, Roland last_name: Bacon - first_name: Jayadev full_name: Pradeep, Jayadev last_name: Pradeep - first_name: Floriane full_name: Leclercq, Floriane last_name: Leclercq - first_name: Haruka full_name: Kusakabe, Haruka last_name: Kusakabe - first_name: Lutz full_name: Wisotzki, Lutz last_name: Wisotzki - first_name: Takuya full_name: Hashimoto, Takuya last_name: Hashimoto - first_name: Kasper B. full_name: Schmidt, Kasper B. last_name: Schmidt - first_name: Jeremy full_name: Blaizot, Jeremy last_name: Blaizot - first_name: Jarle full_name: Brinchmann, Jarle last_name: Brinchmann - first_name: Leindert full_name: Boogaard, Leindert last_name: Boogaard - first_name: Sebastiano full_name: Cantalupo, Sebastiano last_name: Cantalupo - first_name: David full_name: Carton, David last_name: Carton - first_name: Hanae full_name: Inami, Hanae last_name: Inami - first_name: Wolfram full_name: Kollatschny, Wolfram last_name: Kollatschny - first_name: Raffaella A. full_name: Marino, Raffaella A. last_name: Marino - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Themiya full_name: Nanayakkara, Themiya last_name: Nanayakkara - first_name: Johan full_name: Richard, Johan last_name: Richard - first_name: Joop full_name: Schaye, Joop last_name: Schaye - first_name: Laurence full_name: Tresse, Laurence last_name: Tresse - first_name: Tanya full_name: Urrutia, Tanya last_name: Urrutia - first_name: Anne full_name: Verhamme, Anne last_name: Verhamme - first_name: Peter M. full_name: Weilbacher, Peter M. last_name: Weilbacher citation: ama: 'Feltre A, Maseda MV, Bacon R, et al. The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z > 3. Astronomy & Astrophysics. 2020;641. doi:10.1051/0004-6361/202038133' apa: 'Feltre, A., Maseda, M. V., Bacon, R., Pradeep, J., Leclercq, F., Kusakabe, H., … Weilbacher, P. M. (2020). The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z > 3. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202038133' chicago: 'Feltre, Anna, Michael V. Maseda, Roland Bacon, Jayadev Pradeep, Floriane Leclercq, Haruka Kusakabe, Lutz Wisotzki, et al. “The MUSE Hubble Ultra Deep Field Survey: XV. The Mean Rest-UV Spectra of Lyα Emitters at z > 3.” Astronomy & Astrophysics. EDP Sciences, 2020. https://doi.org/10.1051/0004-6361/202038133.' ieee: 'A. Feltre et al., “The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z > 3,” Astronomy & Astrophysics, vol. 641. EDP Sciences, 2020.' ista: 'Feltre A, Maseda MV, Bacon R, Pradeep J, Leclercq F, Kusakabe H, Wisotzki L, Hashimoto T, Schmidt KB, Blaizot J, Brinchmann J, Boogaard L, Cantalupo S, Carton D, Inami H, Kollatschny W, Marino RA, Matthee JJ, Nanayakkara T, Richard J, Schaye J, Tresse L, Urrutia T, Verhamme A, Weilbacher PM. 2020. The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z > 3. Astronomy & Astrophysics. 641, A118.' mla: 'Feltre, Anna, et al. “The MUSE Hubble Ultra Deep Field Survey: XV. The Mean Rest-UV Spectra of Lyα Emitters at z > 3.” Astronomy & Astrophysics, vol. 641, A118, EDP Sciences, 2020, doi:10.1051/0004-6361/202038133.' short: A. Feltre, M.V. Maseda, R. Bacon, J. Pradeep, F. Leclercq, H. Kusakabe, L. Wisotzki, T. Hashimoto, K.B. Schmidt, J. Blaizot, J. Brinchmann, L. Boogaard, S. Cantalupo, D. Carton, H. Inami, W. Kollatschny, R.A. Marino, J.J. Matthee, T. Nanayakkara, J. Richard, J. Schaye, L. Tresse, T. Urrutia, A. Verhamme, P.M. Weilbacher, Astronomy & Astrophysics 641 (2020). date_created: 2022-07-06T09:38:16Z date_published: 2020-09-18T00:00:00Z date_updated: 2022-07-19T09:35:43Z day: '18' doi: 10.1051/0004-6361/202038133 extern: '1' external_id: arxiv: - '2007.01878' intvolume: ' 641' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'galaxies: evolution / galaxies: high-redshift / ISM: lines and bands / ultraviolet: ISM / ultraviolet: galaxies' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2007.01878 month: '09' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' scopus_import: '1' status: public title: 'The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z > 3' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 641 year: '2020' ... --- _id: '11513' abstract: - lang: eng text: We report the spectroscopic confirmation of a new protocluster in the COSMOS field at z ∼ 2.2, COSMOS Cluster 2.2 (CC2.2), originally identified as an overdensity of narrowband selected Hα emitting candidates. With only two masks of Keck/MOSFIRE near-IR spectroscopy in both H (∼1.47–1.81 μm) and K (∼1.92–2.40 μm) bands (∼1.5 hr each), we confirm 35 unique protocluster members with at least two emission lines detected with S/N > 3. Combined with 12 extra members from the zCOSMOS-deep spectroscopic survey (47 in total), we estimate a mean redshift and a line-of-sight velocity dispersion of zmean = 2.23224 ± 0.00101 and σlos = 645 ± 69 km s−1 for this protocluster, respectively. Assuming virialization and spherical symmetry for the system, we estimate a total mass of Mvir ∼ (1–2) ×1014M⊙ for the structure. We evaluate a number density enhancement of δg ∼ 7 for this system and we argue that the structure is likely not fully virialized at z ∼ 2.2. However, in a spherical collapse model, δg is expected to grow to a linear matter enhancement of ∼1.9 by z = 0, exceeding the collapse threshold of 1.69, and leading to a fully collapsed and virialized Coma-type structure with a total mass of Mdyn(z = 0) ∼ 9.2 × 1014M⊙ by now. This observationally efficient confirmation suggests that large narrowband emission-line galaxy surveys, when combined with ancillary photometric data, can be used to effectively trace the large-scale structure and protoclusters at a time when they are mostly dominated by star-forming galaxies. acknowledgement: We are thankful to the anonymous referee for useful comments and suggestions that improved the quality of this paper. B.D. acknowledges financial support from NASA through the Astrophysics Data Analysis Program (ADAP), grant number NNX12AE20G, and the National Science Foundation, grant number 1716907. B.D. is thankful to Andreas Faisst, Laura Danly, and Matthew Burlando for their companionship during the observing run. B.D. is grateful to the COSMOS team for their useful comments during the team meeting in New York City 2019 May 14–17. A.R. research was made possible by Friends of W. M. Keck Observatory who philanthropically support the Keck Science Collaborative (KSC) fund. The observations presented herein were obtained at the W. M. Keck Observatory (program C236, PI Scoville), which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. The authors would like to recognize and acknowledge the very prominent cultural role and reverence that the summit of Maunakea has always had within the indigenous Hawaiian community. We are fortunate to have the opportunity to perform observations from this mountain. article_number: '8' article_processing_charge: No article_type: original author: - first_name: Behnam full_name: Darvish, Behnam last_name: Darvish - first_name: Nick Z. full_name: Scoville, Nick Z. last_name: Scoville - first_name: Christopher full_name: Martin, Christopher last_name: Martin - first_name: David full_name: Sobral, David last_name: Sobral - first_name: Bahram full_name: Mobasher, Bahram last_name: Mobasher - first_name: Alessandro full_name: Rettura, Alessandro last_name: Rettura - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Peter full_name: Capak, Peter last_name: Capak - first_name: Nima full_name: Chartab, Nima last_name: Chartab - first_name: Shoubaneh full_name: Hemmati, Shoubaneh last_name: Hemmati - first_name: Daniel full_name: Masters, Daniel last_name: Masters - first_name: Hooshang full_name: Nayyeri, Hooshang last_name: Nayyeri - first_name: Donal full_name: O’Sullivan, Donal last_name: O’Sullivan - first_name: Ana full_name: Paulino-Afonso, Ana last_name: Paulino-Afonso - first_name: Zahra full_name: Sattari, Zahra last_name: Sattari - first_name: Abtin full_name: Shahidi, Abtin last_name: Shahidi - first_name: Mara full_name: Salvato, Mara last_name: Salvato - first_name: Brian C. full_name: Lemaux, Brian C. last_name: Lemaux - first_name: Olivier Le full_name: Fèvre, Olivier Le last_name: Fèvre - first_name: Olga full_name: Cucciati, Olga last_name: Cucciati citation: ama: Darvish B, Scoville NZ, Martin C, et al. Spectroscopic confirmation of a coma cluster progenitor at z ∼ 2.2. The Astrophysical Journal. 2020;892(1). doi:10.3847/1538-4357/ab75c3 apa: Darvish, B., Scoville, N. Z., Martin, C., Sobral, D., Mobasher, B., Rettura, A., … Cucciati, O. (2020). Spectroscopic confirmation of a coma cluster progenitor at z ∼ 2.2. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ab75c3 chicago: Darvish, Behnam, Nick Z. Scoville, Christopher Martin, David Sobral, Bahram Mobasher, Alessandro Rettura, Jorryt J Matthee, et al. “Spectroscopic Confirmation of a Coma Cluster Progenitor at z ∼ 2.2.” The Astrophysical Journal. IOP Publishing, 2020. https://doi.org/10.3847/1538-4357/ab75c3. ieee: B. Darvish et al., “Spectroscopic confirmation of a coma cluster progenitor at z ∼ 2.2,” The Astrophysical Journal, vol. 892, no. 1. IOP Publishing, 2020. ista: Darvish B, Scoville NZ, Martin C, Sobral D, Mobasher B, Rettura A, Matthee JJ, Capak P, Chartab N, Hemmati S, Masters D, Nayyeri H, O’Sullivan D, Paulino-Afonso A, Sattari Z, Shahidi A, Salvato M, Lemaux BC, Fèvre OL, Cucciati O. 2020. Spectroscopic confirmation of a coma cluster progenitor at z ∼ 2.2. The Astrophysical Journal. 892(1), 8. mla: Darvish, Behnam, et al. “Spectroscopic Confirmation of a Coma Cluster Progenitor at z ∼ 2.2.” The Astrophysical Journal, vol. 892, no. 1, 8, IOP Publishing, 2020, doi:10.3847/1538-4357/ab75c3. short: B. Darvish, N.Z. Scoville, C. Martin, D. Sobral, B. Mobasher, A. Rettura, J.J. Matthee, P. Capak, N. Chartab, S. Hemmati, D. Masters, H. Nayyeri, D. O’Sullivan, A. Paulino-Afonso, Z. Sattari, A. Shahidi, M. Salvato, B.C. Lemaux, O.L. Fèvre, O. Cucciati, The Astrophysical Journal 892 (2020). date_created: 2022-07-06T13:10:51Z date_published: 2020-03-19T00:00:00Z date_updated: 2022-07-19T09:31:35Z day: '19' doi: 10.3847/1538-4357/ab75c3 extern: '1' external_id: arxiv: - '2002.06207' intvolume: ' 892' issue: '1' keyword: - Space and Planetary Science - Astronomy and Astrophysics language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2002.06207 month: '03' oa: 1 oa_version: Preprint publication: The Astrophysical Journal publication_identifier: eissn: - 1538-4357 issn: - 0004-637X publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: Spectroscopic confirmation of a coma cluster progenitor at z ∼ 2.2 type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 892 year: '2020' ... --- _id: '11528' abstract: - lang: eng text: Ly α emission lines are typically found to be redshifted with respect to the systemic redshifts of galaxies, likely due to resonant scattering of Ly α photons. Here, we measure the average velocity offset for a sample of 96 z ≈ 3.3 Ly α emitters (LAEs) with a median Ly α flux (luminosity) of ≈10−17 erg cm−2 s−1 (⁠≈1042 erg s−1⁠) and a median star formation rate (SFR) of ≈1.3 M⊙ yr−1 (not corrected for possible dust extinction), detected by the Multi-Unit Spectroscopic Explorer as part of our MUSEQuBES circumgalactic medium (CGM) survey. By postulating that the stacked CGM absorption profiles of these LAEs, probed by eight background quasars, must be centred on the systemic redshift, we measure an average velocity offset, Voffset = 171\pm 8 km s−1, between the Ly α emission peak and the systemic redshift. The observed Voffset is lower by factors of ≈1.4 and ≈2.6 compared to the velocity offsets measured for narrow-band-selected LAEs and Lyman break galaxies, respectively, which probe galaxies with higher masses and SFRs. Consistent with earlier studies based on direct measurements for individual objects, we find that the Voffset is correlated with the full width at half-maximum of the red peak of the Ly α line, and anticorrelated with the rest-frame equivalent width. Moreover, we find that Voffset is correlated with SFR with a sub-linear scaling relation, Voffset∝SFR0.16±0.03⁠. Adopting the mass scaling for main-sequence galaxies, such a relation suggests that Voffset scales with the circular velocity of the dark matter haloes hosting the LAEs. acknowledgement: 'We thank the anonymous referee for useful suggestions. This study is based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme(s): 094.A-0131(B), 095.A 0200(A), 096.A0222(A), 097.A-0089(A), and 099.A-0159(A). SM acknowledges support from the Alexander von Humboldt Foundation, Germany. SM thanks Christian Herenz for useful discussion. SC gratefully acknowledges support from Swiss National Science Foundation grant PP00P2 163824. JB acknowledges support by FCT/MCTES through national funds by grant UID/FIS/04434/2019 and through Investigador FCT Contract No. IF/01654/2014/CP1215/CT0003. NB and JZ acknowledge support from ANR grant ANR-17-CE31- 0017 (3DGasFlows). AC and JR acknowledge support from the ERC starting grant 336736-CALENDS. MA acknowledges support from European Union’s H2020 Marie Skłodowska-Curie Actions grant 721463 to the SUNDIAL ITN, and from the Spanish Ministry of Economy and Competitiveness (MINECO) under grant number AYA2016-76219-P. MA also acknowledges support from the Fundacion BBVA under its 2017 programme of assistance to ´scientific research groups, for the project ‘Using machine-learning techniques to drag galaxies from the noise in deep imaging’. FL and AV acknowledge support from the ERC starting grant ERC757258-TRIPLE.' article_processing_charge: No article_type: original author: - first_name: Sowgat full_name: Muzahid, Sowgat last_name: Muzahid - first_name: Joop full_name: Schaye, Joop last_name: Schaye - first_name: Raffaella Anna full_name: Marino, Raffaella Anna last_name: Marino - first_name: Sebastiano full_name: Cantalupo, Sebastiano last_name: Cantalupo - first_name: Jarle full_name: Brinchmann, Jarle last_name: Brinchmann - first_name: Thierry full_name: Contini, Thierry last_name: Contini - first_name: Martin full_name: Wendt, Martin last_name: Wendt - first_name: Lutz full_name: Wisotzki, Lutz last_name: Wisotzki - first_name: Johannes full_name: Zabl, Johannes last_name: Zabl - first_name: Nicolas full_name: Bouché, Nicolas last_name: Bouché - first_name: Mohammad full_name: Akhlaghi, Mohammad last_name: Akhlaghi - first_name: Hsiao-Wen full_name: Chen, Hsiao-Wen last_name: Chen - first_name: Adélaîde full_name: Claeyssens, Adélaîde last_name: Claeyssens - first_name: Sean full_name: Johnson, Sean last_name: Johnson - first_name: Floriane full_name: Leclercq, Floriane last_name: Leclercq - first_name: Michael full_name: Maseda, Michael last_name: Maseda - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Johan full_name: Richard, Johan last_name: Richard - first_name: Tanya full_name: Urrutia, Tanya last_name: Urrutia - first_name: Anne full_name: Verhamme, Anne last_name: Verhamme citation: ama: 'Muzahid S, Schaye J, Marino RA, et al. MUSEQuBES: Calibrating the redshifts of Lyα emitters using stacked circumgalactic medium absorption profiles. Monthly Notices of the Royal Astronomical Society. 2020;496(2):1013-1022. doi:10.1093/mnras/staa1347' apa: 'Muzahid, S., Schaye, J., Marino, R. A., Cantalupo, S., Brinchmann, J., Contini, T., … Verhamme, A. (2020). MUSEQuBES: Calibrating the redshifts of Lyα emitters using stacked circumgalactic medium absorption profiles. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa1347' chicago: 'Muzahid, Sowgat, Joop Schaye, Raffaella Anna Marino, Sebastiano Cantalupo, Jarle Brinchmann, Thierry Contini, Martin Wendt, et al. “MUSEQuBES: Calibrating the Redshifts of Lyα Emitters Using Stacked Circumgalactic Medium Absorption Profiles.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/staa1347.' ieee: 'S. Muzahid et al., “MUSEQuBES: Calibrating the redshifts of Lyα emitters using stacked circumgalactic medium absorption profiles,” Monthly Notices of the Royal Astronomical Society, vol. 496, no. 2. Oxford University Press, pp. 1013–1022, 2020.' ista: 'Muzahid S, Schaye J, Marino RA, Cantalupo S, Brinchmann J, Contini T, Wendt M, Wisotzki L, Zabl J, Bouché N, Akhlaghi M, Chen H-W, Claeyssens A, Johnson S, Leclercq F, Maseda M, Matthee JJ, Richard J, Urrutia T, Verhamme A. 2020. MUSEQuBES: Calibrating the redshifts of Lyα emitters using stacked circumgalactic medium absorption profiles. Monthly Notices of the Royal Astronomical Society. 496(2), 1013–1022.' mla: 'Muzahid, Sowgat, et al. “MUSEQuBES: Calibrating the Redshifts of Lyα Emitters Using Stacked Circumgalactic Medium Absorption Profiles.” Monthly Notices of the Royal Astronomical Society, vol. 496, no. 2, Oxford University Press, 2020, pp. 1013–22, doi:10.1093/mnras/staa1347.' short: S. Muzahid, J. Schaye, R.A. Marino, S. Cantalupo, J. Brinchmann, T. Contini, M. Wendt, L. Wisotzki, J. Zabl, N. Bouché, M. Akhlaghi, H.-W. Chen, A. Claeyssens, S. Johnson, F. Leclercq, M. Maseda, J.J. Matthee, J. Richard, T. Urrutia, A. Verhamme, Monthly Notices of the Royal Astronomical Society 496 (2020) 1013–1022. date_created: 2022-07-07T10:20:11Z date_published: 2020-08-01T00:00:00Z date_updated: 2022-08-18T11:00:24Z day: '01' doi: 10.1093/mnras/staa1347 extern: '1' external_id: arxiv: - '1910.03593' intvolume: ' 496' issue: '2' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'galaxies: haloes' - 'galaxies: high-redshift' - 'quasars: absorption lines' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1910.03593 month: '08' oa: 1 oa_version: Preprint page: 1013-1022 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' related_material: link: - relation: erratum url: https://doi.org/10.1093/mnras/staa2668 scopus_import: '1' status: public title: 'MUSEQuBES: Calibrating the redshifts of Lyα emitters using stacked circumgalactic medium absorption profiles' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 496 year: '2020' ... --- _id: '11529' abstract: - lang: eng text: CR7 is among the most luminous Ly α emitters (LAEs) known at z = 6.6 and consists of at least three UV components that are surrounded by Ly α emission. Previous studies have suggested that it may host an extreme ionizing source. Here, we present deep integral field spectroscopy of CR7 with VLT/Multi Unit Spectroscopic Explorer (MUSE). We measure extended emission with a similar halo scale length as typical LAEs at z ≈ 5. CR7’s Ly α halo is clearly elongated along the direction connecting the multiple components, likely tracing the underlying gas distribution. The Ly α emission originates almost exclusively from the brightest UV component, but we also identify a faint kinematically distinct Ly α emitting region nearby a fainter component. Combined with new near-infrared data, the MUSE data show that the rest-frame Ly α equivalent width (EW) is ≈100 Å. This is a factor 4 higher than the EW measured in low-redshift analogues with carefully matched Ly α profiles (and thus arguably H I column density), but this EW can plausibly be explained by star formation. Alternative scenarios requiring active galactic nucleus (AGN) powering are also disfavoured by the narrower and steeper Ly α spectrum and much smaller IR to UV ratio compared to obscured AGN in other Ly α blobs. CR7’s Ly α emission, while extremely luminous, resembles the emission in more common LAEs at lower redshifts very well and is likely powered by a young metal-poor starburst. article_processing_charge: No article_type: original author: - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Gabriele full_name: Pezzulli, Gabriele last_name: Pezzulli - first_name: Ruari full_name: Mackenzie, Ruari last_name: Mackenzie - first_name: Sebastiano full_name: Cantalupo, Sebastiano last_name: Cantalupo - first_name: Haruka full_name: Kusakabe, Haruka last_name: Kusakabe - first_name: Floriane full_name: Leclercq, Floriane last_name: Leclercq - first_name: David full_name: Sobral, David last_name: Sobral - first_name: Johan full_name: Richard, Johan last_name: Richard - first_name: Lutz full_name: Wisotzki, Lutz last_name: Wisotzki - first_name: Simon full_name: Lilly, Simon last_name: Lilly - first_name: Leindert full_name: Boogaard, Leindert last_name: Boogaard - first_name: Raffaella full_name: Marino, Raffaella last_name: Marino - first_name: Michael full_name: Maseda, Michael last_name: Maseda - first_name: Themiya full_name: Nanayakkara, Themiya last_name: Nanayakkara citation: ama: 'Matthee JJ, Pezzulli G, Mackenzie R, et al. The nature of CR7 revealed with MUSE: A young starburst powering extended Ly α emission at z = 6.6. Monthly Notices of the Royal Astronomical Society. 2020;498(2):3043-3059. doi:10.1093/mnras/staa2550' apa: 'Matthee, J. J., Pezzulli, G., Mackenzie, R., Cantalupo, S., Kusakabe, H., Leclercq, F., … Nanayakkara, T. (2020). The nature of CR7 revealed with MUSE: A young starburst powering extended Ly α emission at z = 6.6. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa2550' chicago: 'Matthee, Jorryt J, Gabriele Pezzulli, Ruari Mackenzie, Sebastiano Cantalupo, Haruka Kusakabe, Floriane Leclercq, David Sobral, et al. “The Nature of CR7 Revealed with MUSE: A Young Starburst Powering Extended Ly α Emission at z = 6.6.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/staa2550.' ieee: 'J. J. Matthee et al., “The nature of CR7 revealed with MUSE: A young starburst powering extended Ly α emission at z = 6.6,” Monthly Notices of the Royal Astronomical Society, vol. 498, no. 2. Oxford University Press, pp. 3043–3059, 2020.' ista: 'Matthee JJ, Pezzulli G, Mackenzie R, Cantalupo S, Kusakabe H, Leclercq F, Sobral D, Richard J, Wisotzki L, Lilly S, Boogaard L, Marino R, Maseda M, Nanayakkara T. 2020. The nature of CR7 revealed with MUSE: A young starburst powering extended Ly α emission at z = 6.6. Monthly Notices of the Royal Astronomical Society. 498(2), 3043–3059.' mla: 'Matthee, Jorryt J., et al. “The Nature of CR7 Revealed with MUSE: A Young Starburst Powering Extended Ly α Emission at z = 6.6.” Monthly Notices of the Royal Astronomical Society, vol. 498, no. 2, Oxford University Press, 2020, pp. 3043–59, doi:10.1093/mnras/staa2550.' short: J.J. Matthee, G. Pezzulli, R. Mackenzie, S. Cantalupo, H. Kusakabe, F. Leclercq, D. Sobral, J. Richard, L. Wisotzki, S. Lilly, L. Boogaard, R. Marino, M. Maseda, T. Nanayakkara, Monthly Notices of the Royal Astronomical Society 498 (2020) 3043–3059. date_created: 2022-07-07T10:36:01Z date_published: 2020-10-01T00:00:00Z date_updated: 2022-08-18T11:04:05Z day: '01' doi: 10.1093/mnras/staa2550 extern: '1' external_id: arxiv: - '2008.01731' intvolume: ' 498' issue: '2' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'galaxies: evolution' - 'galaxies: high-redshift' - dark ages - reionization - first stars - 'cosmology: observations' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2008.01731 month: '10' oa: 1 oa_version: Preprint page: 3043-3059 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'The nature of CR7 revealed with MUSE: A young starburst powering extended Ly α emission at z = 6.6' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 498 year: '2020' ... --- _id: '11533' abstract: - lang: eng text: We explore deep rest-frame UV to FIR data in the COSMOS field to measure the individual spectral energy distributions (SED) of the ∼4000 SC4K (Sobral et al.) Lyman α (Ly α) emitters (LAEs) at z ∼ 2–6. We find typical stellar masses of 109.3 ± 0.6 M⊙ and star formation rates (SFR) of SFRSED=4.4+10.5−2.4 M⊙ yr−1 and SFRLyα=5.9+6.3−2.6 M⊙ yr−1, combined with very blue UV slopes of β=−2.1+0.5−0.4⁠, but with significant variations within the population. MUV and β are correlated in a similar way to UV-selected sources, but LAEs are consistently bluer. This suggests that LAEs are the youngest and/or most dust-poor subset of the UV-selected population. We also study the Ly α rest-frame equivalent width (EW0) and find 45 ‘extreme’ LAEs with EW0 > 240 Å (3σ), implying a low number density of (7 ± 1) × 10−7 Mpc−3. Overall, we measure little to no evolution of the Ly α EW0 and scale length parameter (w0), which are consistently high (EW0=140+280−70 Å, w0=129+11−11 Å) from z ∼ 6 to z ∼ 2 and below. However, w0 is anticorrelated with MUV and stellar mass. Our results imply that sources selected as LAEs have a high Ly α escape fraction (fesc,Ly α) irrespective of cosmic time, but fesc,Ly α is still higher for UV-fainter and lower mass LAEs. The least massive LAEs (<109.5 M⊙) are typically located above the star formation ‘main sequence’ (MS), but the offset from the MS decreases towards z ∼ 6 and towards 1010 M⊙. Our results imply a lack of evolution in the properties of LAEs across time and reveals the increasing overlap in properties of LAEs and UV-continuum selected galaxies as typical star-forming galaxies at high redshift effectively become LAEs. acknowledgement: We thank the anonymous referee for the valuable feedback that significantly improved the quality and clarity of this paper. SS and JC acknowledge studentships from Lancaster University. APA acknowledges support from Fundação para a Ciência e a Tecnologia through the project PTDC/FISAST/31546/2017. The authors would like to thank Ali Khostovan, Sara Perez Sanchez, Alex Bennett and Tom Rose for contributions and discussions in the early stages of this work. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under ESO programme ID 179.A-2005 and on data products produced by CALET and the Cambridge Astronomy Survey Unit on behalf of the UltraVISTA consortium. Finally, the authors acknowledge the unique value of the publicly available analysis software TOPCAT (Taylor 2005) and publicly available programming language Python, including the numpy, pyfits, matplotlib, scipy and astropy (Astropy Collaboration et al. 2013) packages. This work is based on the public SC4K sample of LAEs (Sobral et al. 2018a) and we release the full catalogue with all the photometry and properties derived in this paper, in electronic format, along with the relevant tables. article_processing_charge: No article_type: original author: - first_name: S full_name: Santos, S last_name: Santos - first_name: D full_name: Sobral, D last_name: Sobral - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: J full_name: Calhau, J last_name: Calhau - first_name: E full_name: da Cunha, E last_name: da Cunha - first_name: B full_name: Ribeiro, B last_name: Ribeiro - first_name: A full_name: Paulino-Afonso, A last_name: Paulino-Afonso - first_name: P full_name: Arrabal Haro, P last_name: Arrabal Haro - first_name: J full_name: Butterworth, J last_name: Butterworth citation: ama: Santos S, Sobral D, Matthee JJ, et al. The evolution of rest-frame UV properties, Ly α EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs. Monthly Notices of the Royal Astronomical Society. 2020;493(1):141-160. doi:10.1093/mnras/staa093 apa: Santos, S., Sobral, D., Matthee, J. J., Calhau, J., da Cunha, E., Ribeiro, B., … Butterworth, J. (2020). The evolution of rest-frame UV properties, Ly α EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa093 chicago: Santos, S, D Sobral, Jorryt J Matthee, J Calhau, E da Cunha, B Ribeiro, A Paulino-Afonso, P Arrabal Haro, and J Butterworth. “The Evolution of Rest-Frame UV Properties, Ly α EWs, and the SFR–Stellar Mass Relation at z ∼ 2–6 for SC4K LAEs.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/staa093. ieee: S. Santos et al., “The evolution of rest-frame UV properties, Ly α EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs,” Monthly Notices of the Royal Astronomical Society, vol. 493, no. 1. Oxford University Press, pp. 141–160, 2020. ista: Santos S, Sobral D, Matthee JJ, Calhau J, da Cunha E, Ribeiro B, Paulino-Afonso A, Arrabal Haro P, Butterworth J. 2020. The evolution of rest-frame UV properties, Ly α EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs. Monthly Notices of the Royal Astronomical Society. 493(1), 141–160. mla: Santos, S., et al. “The Evolution of Rest-Frame UV Properties, Ly α EWs, and the SFR–Stellar Mass Relation at z ∼ 2–6 for SC4K LAEs.” Monthly Notices of the Royal Astronomical Society, vol. 493, no. 1, Oxford University Press, 2020, pp. 141–60, doi:10.1093/mnras/staa093. short: S. Santos, D. Sobral, J.J. Matthee, J. Calhau, E. da Cunha, B. Ribeiro, A. Paulino-Afonso, P. Arrabal Haro, J. Butterworth, Monthly Notices of the Royal Astronomical Society 493 (2020) 141–160. date_created: 2022-07-07T12:05:23Z date_published: 2020-03-01T00:00:00Z date_updated: 2022-08-18T11:27:43Z day: '01' doi: 10.1093/mnras/staa093 extern: '1' external_id: arxiv: - '1910.02959' intvolume: ' 493' issue: '1' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'galaxies: evolution' - 'galaxies: formation' - 'galaxies: high-redshift' - 'galaxies: star formation' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1910.02959 month: '03' oa: 1 oa_version: Preprint page: 141-160 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: The evolution of rest-frame UV properties, Ly α EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 493 year: '2020' ... --- _id: '11534' abstract: - lang: eng text: The observed properties of the Lyman-α (Ly α) emission line are a powerful probe of neutral gas in and around galaxies. We present spatially resolved Ly α spectroscopy with VLT/MUSE targeting VR7, a UV-luminous galaxy at z = 6.532 with moderate Ly α equivalent width (EW0 ≈ 38 Å). These data are combined with deep resolved [CII]158μm spectroscopy obtained with ALMA and UV imaging from HST and we also detect UV continuum with MUSE. Ly α emission is clearly detected with S/N ≈ 40 and FWHM of 374 km s−1. Ly α and [C II] are similarly extended beyond the UV, with effective radius reff = 2.1 ± 0.2 kpc for a single exponential model or reff,Lyα,halo=3.45+1.08−0.87 kpc when measured jointly with the UV continuum. The Ly α profile is broader and redshifted with respect to the [C II] line (by 213 km s−1), but there are spatial variations that are qualitatively similar in both lines and coincide with resolved UV components. This suggests that the emission originates from two components with plausibly different H I column densities. We place VR7 in the context of other galaxies at similar and lower redshift. The Ly α halo scale length is similar at different redshifts and velocity shifts with respect to the systemic are typically smaller. Overall, we find little indications of a more neutral vicinity at higher redshift. This means that the local (∼10 kpc) neutral gas conditions that determine the observed Ly α properties in VR7 resemble the conditions in post-reionization galaxies. acknowledgement: 'We thank the referee for their suggestions and constructive comments that helped to improve the presentation of our results. Based on observations obtained with the Very Large Telescope, program 99.A-0462. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program #14699. This paper makes use of the following ALMA data: ADS/JAO.ALMA#2017.1.01451.S. ALMA is a partnership of ESO (representing its member states), NSF (USA), and NINS (Japan), together with NRC (Canada) and NSC and ASIAA (Taiwan) and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO, and NAOJ. MG acknowledges support from NASA grant NNX17AK58G. GP and SC gratefully acknowledge support from Swiss National Science Foundation grant PP00P2 163824. BD acknowledges financial support from the National Science Foundation, grant number 1716907. We have benefited greatly from the public available programming language PYTHON, including the NUMPY, MATPLOTLIB, SCIPY (Jones et al. 2001; Hunter 2007; van der Walt, Colbert & Varoquaux 2011) and ASTROPY (Astropy Collaboration 2013) packages, the astronomical imaging tools SEXTRACTOR, SWARP, and SCAMP (Bertin & Arnouts 1996; Bertin 2006, 2010) and the TOPCAT analysis tool (Taylor 2013).' article_processing_charge: No article_type: original author: - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: David full_name: Sobral, David last_name: Sobral - first_name: Max full_name: Gronke, Max last_name: Gronke - first_name: Gabriele full_name: Pezzulli, Gabriele last_name: Pezzulli - first_name: Sebastiano full_name: Cantalupo, Sebastiano last_name: Cantalupo - first_name: Huub full_name: Röttgering, Huub last_name: Röttgering - first_name: Behnam full_name: Darvish, Behnam last_name: Darvish - first_name: Sérgio full_name: Santos, Sérgio last_name: Santos citation: ama: Matthee JJ, Sobral D, Gronke M, et al. Resolved Lyman-α properties of a luminous Lyman-break galaxy in a large ionized bubble at z = 6.53 . Monthly Notices of the Royal Astronomical Society. 2020;492(2):1778-1790. doi:10.1093/mnras/stz3554 apa: Matthee, J. J., Sobral, D., Gronke, M., Pezzulli, G., Cantalupo, S., Röttgering, H., … Santos, S. (2020). Resolved Lyman-α properties of a luminous Lyman-break galaxy in a large ionized bubble at z = 6.53 . Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stz3554 chicago: Matthee, Jorryt J, David Sobral, Max Gronke, Gabriele Pezzulli, Sebastiano Cantalupo, Huub Röttgering, Behnam Darvish, and Sérgio Santos. “Resolved Lyman-α Properties of a Luminous Lyman-Break Galaxy in a Large Ionized Bubble at z = 6.53 .” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/stz3554. ieee: J. J. Matthee et al., “Resolved Lyman-α properties of a luminous Lyman-break galaxy in a large ionized bubble at z = 6.53 ,” Monthly Notices of the Royal Astronomical Society, vol. 492, no. 2. Oxford University Press, pp. 1778–1790, 2020. ista: Matthee JJ, Sobral D, Gronke M, Pezzulli G, Cantalupo S, Röttgering H, Darvish B, Santos S. 2020. Resolved Lyman-α properties of a luminous Lyman-break galaxy in a large ionized bubble at z = 6.53 . Monthly Notices of the Royal Astronomical Society. 492(2), 1778–1790. mla: Matthee, Jorryt J., et al. “Resolved Lyman-α Properties of a Luminous Lyman-Break Galaxy in a Large Ionized Bubble at z = 6.53 .” Monthly Notices of the Royal Astronomical Society, vol. 492, no. 2, Oxford University Press, 2020, pp. 1778–90, doi:10.1093/mnras/stz3554. short: J.J. Matthee, D. Sobral, M. Gronke, G. Pezzulli, S. Cantalupo, H. Röttgering, B. Darvish, S. Santos, Monthly Notices of the Royal Astronomical Society 492 (2020) 1778–1790. date_created: 2022-07-07T12:21:36Z date_published: 2020-02-01T00:00:00Z date_updated: 2022-08-18T11:29:53Z day: '01' doi: 10.1093/mnras/stz3554 extern: '1' external_id: arxiv: - '1909.06376' intvolume: ' 492' issue: '2' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'galaxies: evolution' - 'galaxies: high-redshift' - dark ages - reionization - first stars - 'cosmology: observations' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1909.06376 month: '02' oa: 1 oa_version: Preprint page: 1778-1790 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'Resolved Lyman-α properties of a luminous Lyman-break galaxy in a large ionized bubble at z = 6.53 ' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 492 year: '2020' ... --- _id: '11531' abstract: - lang: eng text: While low-luminosity galaxies dominate number counts at all redshifts, their contribution to cosmic reionization is poorly understood due to a lack of knowledge of their physical properties. We isolate a sample of 35 z ≈ 4–5 continuum-faint Lyman-α emitters from deep VLT/MUSE spectroscopy and directly measure their H α emission using stacked Spitzer/IRAC Ch. 1 photometry. Based on Hubble Space Telescope imaging, we determine that the average UV continuum magnitude is fainter than −16 (≈ 0.01 L⋆), implying a median Lyman-α equivalent width of 259 Å. By combining the H α measurement with the UV magnitude, we determine the ionizing photon production efficiency, ξion, a first for such faint galaxies. The measurement of log10 (ξion [Hz erg−1]) = 26.28 (⁠+0.28−0.40⁠) is in excess of literature measurements of both continuum- and emission line-selected samples, implying a more efficient production of ionizing photons in these lower luminosity, Lyman-α-selected systems. We conclude that this elevated efficiency can be explained by stellar populations with metallicities between 4 × 10−4 and 0.008, with light-weighted ages less than 3 Myr. acknowledgement: 'We would like to thank the anonymous referee for a thoughtful report and suggestions that have improved this manuscript. We are also grateful to everyone involved in the Spitzer Space Telescope mission and everyone at the Spitzer Science Center: we are truly fortunate to have been able to use data from this facility. J. B. acknowledges support by FCT/MCTES through national funds by this grant UID/FIS/04434/2019 and through the Investigador FCT contract no. IF/01654/2014/CP1215/CT0003. S. C. gratefully acknowledges support from Swiss National Science Foundation grant PP00P2 163824. We would also like to thank Mauro Stefanon for his assistance with de-blending the IRAC photometry, Pieter van Dokkum for a number of useful suggestions, and Daniel Schaerer for information regarding the stellar population models. This study is based on observations made with ESO telescopes at the La Silla Paranal Observatory under programs IDs 094.A-2089(B), 095.A0010(A), 096.A-0045(A), and 096.A-0045(B).' article_processing_charge: No article_type: original author: - first_name: Michael V full_name: Maseda, Michael V last_name: Maseda - first_name: Roland full_name: Bacon, Roland last_name: Bacon - first_name: Daniel full_name: Lam, Daniel last_name: Lam - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Jarle full_name: Brinchmann, Jarle last_name: Brinchmann - first_name: Joop full_name: Schaye, Joop last_name: Schaye - first_name: Ivo full_name: Labbe, Ivo last_name: Labbe - first_name: Kasper B full_name: Schmidt, Kasper B last_name: Schmidt - first_name: Leindert full_name: Boogaard, Leindert last_name: Boogaard - first_name: Rychard full_name: Bouwens, Rychard last_name: Bouwens - first_name: Sebastiano full_name: Cantalupo, Sebastiano last_name: Cantalupo - first_name: Marijn full_name: Franx, Marijn last_name: Franx - first_name: Takuya full_name: Hashimoto, Takuya last_name: Hashimoto - first_name: Hanae full_name: Inami, Hanae last_name: Inami - first_name: Haruka full_name: Kusakabe, Haruka last_name: Kusakabe - first_name: Guillaume full_name: Mahler, Guillaume last_name: Mahler - first_name: Themiya full_name: Nanayakkara, Themiya last_name: Nanayakkara - first_name: Johan full_name: Richard, Johan last_name: Richard - first_name: Lutz full_name: Wisotzki, Lutz last_name: Wisotzki citation: ama: Maseda MV, Bacon R, Lam D, et al. Elevated ionizing photon production efficiency in faint high-equivalent-width Lyman-α emitters. Monthly Notices of the Royal Astronomical Society. 2020;493(4):5120-5130. doi:10.1093/mnras/staa622 apa: Maseda, M. V., Bacon, R., Lam, D., Matthee, J. J., Brinchmann, J., Schaye, J., … Wisotzki, L. (2020). Elevated ionizing photon production efficiency in faint high-equivalent-width Lyman-α emitters. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa622 chicago: Maseda, Michael V, Roland Bacon, Daniel Lam, Jorryt J Matthee, Jarle Brinchmann, Joop Schaye, Ivo Labbe, et al. “Elevated Ionizing Photon Production Efficiency in Faint High-Equivalent-Width Lyman-α Emitters.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/staa622. ieee: M. V. Maseda et al., “Elevated ionizing photon production efficiency in faint high-equivalent-width Lyman-α emitters,” Monthly Notices of the Royal Astronomical Society, vol. 493, no. 4. Oxford University Press, pp. 5120–5130, 2020. ista: Maseda MV, Bacon R, Lam D, Matthee JJ, Brinchmann J, Schaye J, Labbe I, Schmidt KB, Boogaard L, Bouwens R, Cantalupo S, Franx M, Hashimoto T, Inami H, Kusakabe H, Mahler G, Nanayakkara T, Richard J, Wisotzki L. 2020. Elevated ionizing photon production efficiency in faint high-equivalent-width Lyman-α emitters. Monthly Notices of the Royal Astronomical Society. 493(4), 5120–5130. mla: Maseda, Michael V., et al. “Elevated Ionizing Photon Production Efficiency in Faint High-Equivalent-Width Lyman-α Emitters.” Monthly Notices of the Royal Astronomical Society, vol. 493, no. 4, Oxford University Press, 2020, pp. 5120–30, doi:10.1093/mnras/staa622. short: M.V. Maseda, R. Bacon, D. Lam, J.J. Matthee, J. Brinchmann, J. Schaye, I. Labbe, K.B. Schmidt, L. Boogaard, R. Bouwens, S. Cantalupo, M. Franx, T. Hashimoto, H. Inami, H. Kusakabe, G. Mahler, T. Nanayakkara, J. Richard, L. Wisotzki, Monthly Notices of the Royal Astronomical Society 493 (2020) 5120–5130. date_created: 2022-07-07T10:46:41Z date_published: 2020-04-01T00:00:00Z date_updated: 2022-08-18T11:23:27Z day: '01' doi: 10.1093/mnras/staa622 extern: '1' external_id: arxiv: - '2002.11117' intvolume: ' 493' issue: '4' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'Galaxies: evolution' - 'Galaxies: high-redshift' - 'Galaxies: ISM' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1093/mnras/staa622 month: '04' oa: 1 oa_version: Published Version page: 5120-5130 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: Elevated ionizing photon production efficiency in faint high-equivalent-width Lyman-α emitters type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 493 year: '2020' ... --- _id: '11530' abstract: - lang: eng text: A prediction of the classic active galactic nucleus (AGN) unification model is the presence of ionization cones with different orientations depending on the AGN type. Confirmations of this model exist for present times, but it is less clear in the early Universe. Here, we use the morphology of giant Ly α nebulae around AGNs at redshift z ∼ 3 to probe AGN emission and therefore the validity of the AGN unification model at this redshift. We compare the spatial morphology of 19 nebulae previously found around type I AGNs with a new sample of four Ly α nebulae detected around type II AGNs. Using two independent techniques, we find that nebulae around type II AGNs are more asymmetric than around type I, at least at radial distances r > 30 physical kpc (pkpc) from the ionizing source. We conclude that the type I and type II AGNs in our sample show evidence of different surrounding ionizing geometries. This suggests that the classical AGN unification model is also valid for high-redshift sources. Finally, we discuss how the lack of asymmetry in the inner parts (r ≲ 30 pkpc) and the associated high values of the He II to Ly α ratios in these regions could indicate additional sources of (hard) ionizing radiation originating within or in proximity of the AGN host galaxies. This work demonstrates that the morphologies of giant Ly α nebulae can be used to understand and study the geometry of high-redshift AGNs on circumnuclear scales and it lays the foundation for future studies using much larger statistical samples. acknowledgement: SC and GP gratefully acknowledge support from Swiss National Science Foundation grant PP00P2 163824. MK acknowledges support by DLR500R1904. article_processing_charge: No article_type: original author: - first_name: J S full_name: den Brok, J S last_name: den Brok - first_name: S full_name: Cantalupo, S last_name: Cantalupo - first_name: R full_name: Mackenzie, R last_name: Mackenzie - first_name: R A full_name: Marino, R A last_name: Marino - first_name: G full_name: Pezzulli, G last_name: Pezzulli - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: S D full_name: Johnson, S D last_name: Johnson - first_name: M full_name: Krumpe, M last_name: Krumpe - first_name: T full_name: Urrutia, T last_name: Urrutia - first_name: W full_name: Kollatschny, W last_name: Kollatschny citation: ama: den Brok JS, Cantalupo S, Mackenzie R, et al. Probing the AGN unification model at redshift z ∼ 3 with MUSE observations of giant Lyα nebulae. Monthly Notices of the Royal Astronomical Society. 2020;495(2):1874-1887. doi:10.1093/mnras/staa1269 apa: den Brok, J. S., Cantalupo, S., Mackenzie, R., Marino, R. A., Pezzulli, G., Matthee, J. J., … Kollatschny, W. (2020). Probing the AGN unification model at redshift z ∼ 3 with MUSE observations of giant Lyα nebulae. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa1269 chicago: den Brok, J S, S Cantalupo, R Mackenzie, R A Marino, G Pezzulli, Jorryt J Matthee, S D Johnson, M Krumpe, T Urrutia, and W Kollatschny. “Probing the AGN Unification Model at Redshift z ∼ 3 with MUSE Observations of Giant Lyα Nebulae.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/staa1269. ieee: J. S. den Brok et al., “Probing the AGN unification model at redshift z ∼ 3 with MUSE observations of giant Lyα nebulae,” Monthly Notices of the Royal Astronomical Society, vol. 495, no. 2. Oxford University Press, pp. 1874–1887, 2020. ista: den Brok JS, Cantalupo S, Mackenzie R, Marino RA, Pezzulli G, Matthee JJ, Johnson SD, Krumpe M, Urrutia T, Kollatschny W. 2020. Probing the AGN unification model at redshift z ∼ 3 with MUSE observations of giant Lyα nebulae. Monthly Notices of the Royal Astronomical Society. 495(2), 1874–1887. mla: den Brok, J. S., et al. “Probing the AGN Unification Model at Redshift z ∼ 3 with MUSE Observations of Giant Lyα Nebulae.” Monthly Notices of the Royal Astronomical Society, vol. 495, no. 2, Oxford University Press, 2020, pp. 1874–87, doi:10.1093/mnras/staa1269. short: J.S. den Brok, S. Cantalupo, R. Mackenzie, R.A. Marino, G. Pezzulli, J.J. Matthee, S.D. Johnson, M. Krumpe, T. Urrutia, W. Kollatschny, Monthly Notices of the Royal Astronomical Society 495 (2020) 1874–1887. date_created: 2022-07-07T10:40:17Z date_published: 2020-06-01T00:00:00Z date_updated: 2022-08-18T11:17:47Z day: '01' doi: 10.1093/mnras/staa1269 extern: '1' external_id: arxiv: - '2005.01732' intvolume: ' 495' issue: '2' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'galaxies: active' - 'galaxies: high-redshift' - intergalactic medium - 'quasars: emission lines' - 'quasars: general' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2005.01732 month: '06' oa: 1 oa_version: Preprint page: 1874-1887 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: Probing the AGN unification model at redshift z ∼ 3 with MUSE observations of giant Lyα nebulae type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 495 year: '2020' ... --- _id: '11539' abstract: - lang: eng text: 'Despite recent progress in understanding Ly α emitters (LAEs), relatively little is known regarding their typical black hole activity across cosmic time. Here, we study the X-ray and radio properties of ∼4000 LAEs at 2.2 < z < 6 from the SC4K survey in the COSMOS field. We detect 254 (⁠6.8per cent±0.4per cent⁠) LAEs individually in the X-rays (S/N > 3) with an average luminosity of 1044.31±0.01ergs−1 and average black hole accretion rate (BHAR) of 0.72±0.01 M⊙ yr−1, consistent with moderate to high accreting active galactic neuclei (AGNs). We detect 120 sources in deep radio data (radio AGN fraction of 3.2per cent±0.3per cent⁠). The global AGN fraction (⁠8.6per cent±0.4per cent⁠) rises with Ly α luminosity and declines with increasing redshift. For X-ray-detected LAEs, Ly α luminosities correlate with the BHARs, suggesting that Ly α luminosity becomes a BHAR indicator. Most LAEs (⁠93.1per cent±0.6per cent⁠) at 2 < z < 6 have no detectable X-ray emission (BHARs < 0.017 M⊙ yr−1). The median star formation rate (SFR) of star-forming LAEs from Ly α and radio luminosities is 7.6+6.6−2.8 M⊙ yr−1. The black hole to galaxy growth ratio (BHAR/SFR) for LAEs is <0.0022, consistent with typical star-forming galaxies and the local BHAR/SFR relation. We conclude that LAEs at 2 < z < 6 include two different populations: an AGN population, where Ly α luminosity traces BHAR, and another with low SFRs which remain undetected in even the deepest X-ray stacks but is detected in the radio stacks.' acknowledgement: JM acknowledges the support of a Huygens PhD fellowship from Leiden University. We thank Camila Correa for help analysing snipshot merger trees. We thank the anonymous referee for constructive comments. We also thank Jarle Brinchmann, Rob Crain, Antonios Katsianis, Paola Popesso, and David Sobral for discussions and suggestions. We also thank the participants of the Lorentz Center workshop ‘A Decade of the Star-Forming Main Sequence’ held on 2017 September 4–8, for discussions and ideas. We have benefited from the public available programming language PYTHON, including the NUMPY, MATPLOTLIB, and SCIPY (Hunter 2007) packages and the TOPCAT analysis tool (Taylor 2013). article_processing_charge: No article_type: original author: - first_name: João full_name: Calhau, João last_name: Calhau - first_name: David full_name: Sobral, David last_name: Sobral - first_name: Sérgio full_name: Santos, Sérgio last_name: Santos - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Ana full_name: Paulino-Afonso, Ana last_name: Paulino-Afonso - first_name: Andra full_name: Stroe, Andra last_name: Stroe - first_name: Brooke full_name: Simmons, Brooke last_name: Simmons - first_name: Cassandra full_name: Barlow-Hall, Cassandra last_name: Barlow-Hall - first_name: Benjamin full_name: Adams, Benjamin last_name: Adams citation: ama: 'Calhau J, Sobral D, Santos S, et al. The X-ray and radio activity of typical and luminous Ly α emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving population. Monthly Notices of the Royal Astronomical Society. 2020;493(3):3341-3362. doi:10.1093/mnras/staa476' apa: 'Calhau, J., Sobral, D., Santos, S., Matthee, J. J., Paulino-Afonso, A., Stroe, A., … Adams, B. (2020). The X-ray and radio activity of typical and luminous Ly α emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving population. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa476' chicago: 'Calhau, João, David Sobral, Sérgio Santos, Jorryt J Matthee, Ana Paulino-Afonso, Andra Stroe, Brooke Simmons, Cassandra Barlow-Hall, and Benjamin Adams. “The X-Ray and Radio Activity of Typical and Luminous Ly α Emitters from z ∼ 2 to z ∼ 6: Evidence for a Diverse, Evolving Population.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/staa476.' ieee: 'J. Calhau et al., “The X-ray and radio activity of typical and luminous Ly α emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving population,” Monthly Notices of the Royal Astronomical Society, vol. 493, no. 3. Oxford University Press, pp. 3341–3362, 2020.' ista: 'Calhau J, Sobral D, Santos S, Matthee JJ, Paulino-Afonso A, Stroe A, Simmons B, Barlow-Hall C, Adams B. 2020. The X-ray and radio activity of typical and luminous Ly α emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving population. Monthly Notices of the Royal Astronomical Society. 493(3), 3341–3362.' mla: 'Calhau, João, et al. “The X-Ray and Radio Activity of Typical and Luminous Ly α Emitters from z ∼ 2 to z ∼ 6: Evidence for a Diverse, Evolving Population.” Monthly Notices of the Royal Astronomical Society, vol. 493, no. 3, Oxford University Press, 2020, pp. 3341–62, doi:10.1093/mnras/staa476.' short: J. Calhau, D. Sobral, S. Santos, J.J. Matthee, A. Paulino-Afonso, A. Stroe, B. Simmons, C. Barlow-Hall, B. Adams, Monthly Notices of the Royal Astronomical Society 493 (2020) 3341–3362. date_created: 2022-07-08T07:34:10Z date_published: 2020-04-01T00:00:00Z date_updated: 2022-08-18T11:25:31Z day: '01' doi: 10.1093/mnras/staa476 extern: '1' external_id: arxiv: - '1909.11672' intvolume: ' 493' issue: '3' keyword: - Space and Planetary Science - Astronomy and Astrophysics - 'galaxies: active' - 'galaxies: evolution' - 'galaxies: high-redshift' - 'quasars: supermassive black holes' - 'galaxies: star formation' - 'cosmology: observations' - 'X-rays: galaxies' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1909.11672 month: '04' oa: 1 oa_version: Preprint page: 3341-3362 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: 'The X-ray and radio activity of typical and luminous Ly α emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving population' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 493 year: '2020' ... --- _id: '11586' abstract: - lang: eng text: Distant luminous Lyman-α emitters are excellent targets for detailed observations of galaxies in the epoch of reionisation. Spatially resolved observations of these galaxies allow us to simultaneously probe the emission from young stars, partially ionised gas in the interstellar medium and to constrain the properties of the surrounding hydrogen in the circumgalactic medium. We review recent results from (spectroscopic) follow-up studies of the rest-frame UV, Lyman-α and [CII] emission in luminous galaxies observed ∼500 Myr after the Big Bang with ALMA, HST/WFC3 and VLT/X-SHOOTER. These galaxies likely reside in early ionised bubbles and are complex systems, consisting of multiple well separated and resolved components where traces of metals are already present. article_processing_charge: No author: - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: David full_name: Sobral, David last_name: Sobral citation: ama: 'Matthee JJ, Sobral D. Unveiling the most luminous Lyman-α emitters in the epoch of reionisation. In: Proceedings of the International Astronomical Union. Vol 15. Cambridge University Press; 2020:21-25. doi:10.1017/s1743921319009451' apa: Matthee, J. J., & Sobral, D. (2020). Unveiling the most luminous Lyman-α emitters in the epoch of reionisation. In Proceedings of the International Astronomical Union (Vol. 15, pp. 21–25). Cambridge University Press. https://doi.org/10.1017/s1743921319009451 chicago: Matthee, Jorryt J, and David Sobral. “Unveiling the Most Luminous Lyman-α Emitters in the Epoch of Reionisation.” In Proceedings of the International Astronomical Union, 15:21–25. Cambridge University Press, 2020. https://doi.org/10.1017/s1743921319009451. ieee: J. J. Matthee and D. Sobral, “Unveiling the most luminous Lyman-α emitters in the epoch of reionisation,” in Proceedings of the International Astronomical Union, 2020, vol. 15, no. S352, pp. 21–25. ista: Matthee JJ, Sobral D. 2020. Unveiling the most luminous Lyman-α emitters in the epoch of reionisation. Proceedings of the International Astronomical Union. vol. 15, 21–25. mla: Matthee, Jorryt J., and David Sobral. “Unveiling the Most Luminous Lyman-α Emitters in the Epoch of Reionisation.” Proceedings of the International Astronomical Union, vol. 15, no. S352, Cambridge University Press, 2020, pp. 21–25, doi:10.1017/s1743921319009451. short: J.J. Matthee, D. Sobral, in:, Proceedings of the International Astronomical Union, Cambridge University Press, 2020, pp. 21–25. date_created: 2022-07-14T14:08:41Z date_published: 2020-06-04T00:00:00Z date_updated: 2022-08-19T08:41:12Z day: '04' doi: 10.1017/s1743921319009451 extern: '1' external_id: arxiv: - '1911.04774' intvolume: ' 15' issue: S352 keyword: - Astronomy and Astrophysics - Space and Planetary Science - 'galaxies: formation' - 'galaxies: evolution' - 'galaxies: high-redshift' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1911.04774 month: '06' oa: 1 oa_version: Preprint page: 21-25 publication: Proceedings of the International Astronomical Union publication_identifier: eissn: - 1743-9221 issn: - 1743-9213 publication_status: published publisher: Cambridge University Press quality_controlled: '1' scopus_import: '1' status: public title: Unveiling the most luminous Lyman-α emitters in the epoch of reionisation type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 15 year: '2020' ... --- _id: '11610' abstract: - lang: eng text: Studies of Galactic structure and evolution have benefited enormously from Gaia kinematic information, though additional, intrinsic stellar parameters like age are required to best constrain Galactic models. Asteroseismology is the most precise method of providing such information for field star populations en masse, but existing samples for the most part have been limited to a few narrow fields of view by the CoRoT and Kepler missions. In an effort to provide well-characterized stellar parameters across a wide range in Galactic position, we present the second data release of red giant asteroseismic parameters for the K2 Galactic Archaeology Program (GAP). We provide ${\nu }_{\max }$ and ${\rm{\Delta }}\nu $ based on six independent pipeline analyses; first-ascent red giant branch (RGB) and red clump (RC) evolutionary state classifications from machine learning; and ready-to-use radius and mass coefficients, κR and κM, which, when appropriately multiplied by a solar-scaled effective temperature factor, yield physical stellar radii and masses. In total, we report 4395 radius and mass coefficients, with typical uncertainties of 3.3% (stat.) ± 1% (syst.) for κR and 7.7% (stat.) ± 2% (syst.) for κM among RGB stars, and 5.0% (stat.) ± 1% (syst.) for κR and 10.5% (stat.) ± 2% (syst.) for κM among RC stars. We verify that the sample is nearly complete—except for a dearth of stars with ${\nu }_{\max }\lesssim 10\mbox{--}20\,\mu \mathrm{Hz}$—by comparing to Galactic models and visual inspection. Our asteroseismic radii agree with radii derived from Gaia Data Release 2 parallaxes to within 2.2% ± 0.3% for RGB stars and 2.0% ± 0.6% for RC stars. acknowledgement: "We thank the referee for comments that strengthened the manuscript. J. C. Z. and M. H. P. acknowledge support from NASA grants 80NSSC18K0391 and NNX17AJ40G. Y. E. and C. J. acknowledge the support of the UK Science and Technology Facilities Council (STFC). S. M. would like to acknowledge support from the Spanish Ministry with the Ramon y Cajal fellowship number RYC-2015-17697. R. A. G. acknowledges funding received from the PLATO CNES grant. R. S. acknowledges funding via a Royal Society University Research Fellowship. D.H. acknowledges support from the Alfred P. Sloan Foundation and the National Aeronautics and Space Administration (80NSSC19K0108). V.S.A. acknowledges support from the Independent Research Fund Denmark (Research grant 7027-00096B), and the Carlsberg foundation (grant agreement CF19-0649). This research was supported in part by the National Science Foundation under grant No. NSF PHY-1748958.\r\n\r\nFunding for the Stellar Astrophysics Centre (SAC) is provided by The Danish National Research Foundation (grant agreement No. DNRF106).\r\n\r\nThe K2 Galactic Archaeology Program is supported by the National Aeronautics and Space Administration under grant NNX16AJ17G issued through the K2 Guest Observer Program.\r\n\r\nThis publication makes use of data products from the Two Micron All Sky Survey, which is a joint project of the University of Massachusetts and the Infrared Processing and Analysis Center/California Institute of Technology, funded by the National Aeronautics and Space Administration and the National Science Foundation.\r\n\r\nThis work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement.\r\n\r\nFunding for the Sloan Digital Sky Survey IV has been provided by the Alfred P. Sloan Foundation, the U.S. Department of Energy Office of Science, and the Participating Institutions. SDSS-IV acknowledges support and resources from the Center for High Performance Computing at the University of Utah. The SDSS website is www.sdss.org.\r\n\r\nSDSS-IV is managed by the Astrophysical Research Consortium for the Participating Institutions of the SDSS Collaboration, including the Brazilian Participation Group, the Carnegie Institution for Science, Carnegie Mellon University, the Chilean Participation Group, the French Participation Group, the Harvard–Smithsonian Center for Astrophysics, Instituto de Astrofísica de Canarias, The Johns Hopkins University, Kavli Institute for the Physics and Mathematics of the Universe (IPMU)/University of Tokyo, the Korean Participation Group, Lawrence Berkeley National Laboratory, Leibniz Institut für Astrophysik Potsdam (AIP), Max-Planck-Institut für Astronomie (MPIA Heidelberg), Max-Planck-Institut für Astrophysik (MPA Garching), Max-Planck-Institut für Extraterrestrische Physik (MPE), National Astronomical Observatories of China, New Mexico State University, New York University, University of Notre Dame, Observatário Nacional/MCTI, The Ohio State University, Pennsylvania State University, Shanghai Astronomical Observatory, United Kingdom Participation Group, Universidad Nacional Autónoma de México, University of Arizona, University of Colorado Boulder, University of Oxford, University of Portsmouth, University of Utah, University of Virginia, University of Washington, University of Wisconsin, Vanderbilt University, and Yale University.\r\n\r\nSoftware: asfgrid (Sharma & Stello 2016), emcee (Foreman-Mackey et al. 2013), NumPy (Walt 2011), pandas (McKinney 2010; Reback et al. 2020), Matplotlib (Hunter 2007), IPython (Pérez & Granger 2007), SciPy (Virtanen et al. 2020)." article_number: '23' article_processing_charge: No article_type: original author: - first_name: Joel C. full_name: Zinn, Joel C. last_name: Zinn - first_name: Dennis full_name: Stello, Dennis last_name: Stello - first_name: Yvonne full_name: Elsworth, Yvonne last_name: Elsworth - first_name: Rafael A. full_name: García, Rafael A. last_name: García - first_name: Thomas full_name: Kallinger, Thomas last_name: Kallinger - first_name: Savita full_name: Mathur, Savita last_name: Mathur - first_name: Benoît full_name: Mosser, Benoît last_name: Mosser - first_name: Lisa Annabelle full_name: Bugnet, Lisa Annabelle id: d9edb345-f866-11ec-9b37-d119b5234501 last_name: Bugnet orcid: 0000-0003-0142-4000 - first_name: Caitlin full_name: Jones, Caitlin last_name: Jones - first_name: Marc full_name: Hon, Marc last_name: Hon - first_name: Sanjib full_name: Sharma, Sanjib last_name: Sharma - first_name: Ralph full_name: Schönrich, Ralph last_name: Schönrich - first_name: Jack T. full_name: Warfield, Jack T. last_name: Warfield - first_name: Rodrigo full_name: Luger, Rodrigo last_name: Luger - first_name: Marc H. full_name: Pinsonneault, Marc H. last_name: Pinsonneault - first_name: Jennifer A. full_name: Johnson, Jennifer A. last_name: Johnson - first_name: Daniel full_name: Huber, Daniel last_name: Huber - first_name: Victor Silva full_name: Aguirre, Victor Silva last_name: Aguirre - first_name: William J. full_name: Chaplin, William J. last_name: Chaplin - first_name: Guy R. full_name: Davies, Guy R. last_name: Davies - first_name: Andrea full_name: Miglio, Andrea last_name: Miglio citation: ama: 'Zinn JC, Stello D, Elsworth Y, et al. The K2 galactic archaeology program data release 2: Asteroseismic results from campaigns 4, 6, and 7. The Astrophysical Journal Supplement Series. 2020;251(2). doi:10.3847/1538-4365/abbee3' apa: 'Zinn, J. C., Stello, D., Elsworth, Y., García, R. A., Kallinger, T., Mathur, S., … Miglio, A. (2020). The K2 galactic archaeology program data release 2: Asteroseismic results from campaigns 4, 6, and 7. The Astrophysical Journal Supplement Series. IOP Publishing. https://doi.org/10.3847/1538-4365/abbee3' chicago: 'Zinn, Joel C., Dennis Stello, Yvonne Elsworth, Rafael A. García, Thomas Kallinger, Savita Mathur, Benoît Mosser, et al. “The K2 Galactic Archaeology Program Data Release 2: Asteroseismic Results from Campaigns 4, 6, and 7.” The Astrophysical Journal Supplement Series. IOP Publishing, 2020. https://doi.org/10.3847/1538-4365/abbee3.' ieee: 'J. C. Zinn et al., “The K2 galactic archaeology program data release 2: Asteroseismic results from campaigns 4, 6, and 7,” The Astrophysical Journal Supplement Series, vol. 251, no. 2. IOP Publishing, 2020.' ista: 'Zinn JC, Stello D, Elsworth Y, García RA, Kallinger T, Mathur S, Mosser B, Bugnet LA, Jones C, Hon M, Sharma S, Schönrich R, Warfield JT, Luger R, Pinsonneault MH, Johnson JA, Huber D, Aguirre VS, Chaplin WJ, Davies GR, Miglio A. 2020. The K2 galactic archaeology program data release 2: Asteroseismic results from campaigns 4, 6, and 7. The Astrophysical Journal Supplement Series. 251(2), 23.' mla: 'Zinn, Joel C., et al. “The K2 Galactic Archaeology Program Data Release 2: Asteroseismic Results from Campaigns 4, 6, and 7.” The Astrophysical Journal Supplement Series, vol. 251, no. 2, 23, IOP Publishing, 2020, doi:10.3847/1538-4365/abbee3.' short: J.C. Zinn, D. Stello, Y. Elsworth, R.A. García, T. Kallinger, S. Mathur, B. Mosser, L.A. Bugnet, C. Jones, M. Hon, S. Sharma, R. Schönrich, J.T. Warfield, R. Luger, M.H. Pinsonneault, J.A. Johnson, D. Huber, V.S. Aguirre, W.J. Chaplin, G.R. Davies, A. Miglio, The Astrophysical Journal Supplement Series 251 (2020). date_created: 2022-07-18T13:27:26Z date_published: 2020-12-01T00:00:00Z date_updated: 2022-08-22T07:04:45Z day: '01' doi: 10.3847/1538-4365/abbee3 extern: '1' external_id: arxiv: - '2012.04051' intvolume: ' 251' issue: '2' keyword: - Space and Planetary Science - Astronomy and Astrophysics language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2012.04051 month: '12' oa: 1 oa_version: Preprint publication: The Astrophysical Journal Supplement Series publication_identifier: eissn: - 1538-4365 issn: - 0067-0049 publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: 'The K2 galactic archaeology program data release 2: Asteroseismic results from campaigns 4, 6, and 7' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 251 year: '2020' ... --- _id: '11611' abstract: - lang: eng text: Over the course of its history, the Milky Way has ingested multiple smaller satellite galaxies1. Although these accreted stellar populations can be forensically identified as kinematically distinct structures within the Galaxy, it is difficult in general to date precisely the age at which any one merger occurred. Recent results have revealed a population of stars that were accreted via the collision of a dwarf galaxy, called Gaia–Enceladus1, leading to substantial pollution of the chemical and dynamical properties of the Milky Way. Here we identify the very bright, naked-eye star ν Indi as an indicator of the age of the early in situ population of the Galaxy. We combine asteroseismic, spectroscopic, astrometric and kinematic observations to show that this metal-poor, alpha-element-rich star was an indigenous member of the halo, and we measure its age to be 11.0±0.7 (stat) ±0.8 (sys) billion years. The star bears hallmarks consistent with having been kinematically heated by the Gaia–Enceladus collision. Its age implies that the earliest the merger could have begun was 11.6 and 13.2 billion years ago, at 68% and 95% confidence, respectively. Computations based on hierarchical cosmological models slightly reduce the above limits. acknowledgement: This paper includes data collected by the TESS mission, which are publicly available from the Mikulski Archive for Space Telescopes (MAST). Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center for the production of the SPOC data products. W.J.C. acknowledges support from the UK Science and Technology Facilities Council (STFC) and UK Space Agency. Funding for the Stellar Astrophysics Centre is provided by The Danish National Research Foundation (grant agreement number DNRF106). This research was partially conducted during the Exostar19 programme at the Kavli Institute for Theoretical Physics at UC Santa Barbara, which was supported in part by the National Science Foundation under grant number NSF PHY-1748958. A.M., J.T.M., F.V. and J.M. acknowledge support from the ERC Consolidator Grant funding scheme (project ASTEROCHRONOMETRY, grant agreement number 772293). F.V. acknowledges the support of a Fellowship from the Center for Cosmology and AstroParticle Physics at The Ohio State University. W.H.B. and M.B.N. acknowledge support from the UK Space Agency. K.J.B. is supported by the National Science Foundation under award AST-1903828. M.B.N. acknowledges partial support from the NYU Abu Dhabi Center for Space Science under grant number G1502. A.M.S. is partially supported by the Spanish Government (ESP2017-82674-R) and Generalitat de Catalunya (2017-SGR-1131). T.M. acknowledges financial support from Belspo for contract PRODEX PLATO. H.K. acknowledges support from the European Social Fund via the Lithuanian Science Council grant number 09.3.3-LMT-K-712-01-0103. S.B. acknowledges support from NSF grant AST-1514676 and NASA grant 80NSSC19K0374. V.S.A. acknowledges support from the Independent Research Fund Denmark (research grant 7027-00096B). D.H. acknowledges support by the National Aeronautics and Space Administration (80NSSC18K1585, 80NSSC19K0379) awarded through the TESS Guest Investigator Program and by the National Science Foundation (AST-1717000). T.S.M. acknowledges support from a visiting fellowship at the Max Planck Institute for Solar System Research. Computational resources were provided through XSEDE allocation TG-AST090107. D.L.B. acknowledges support from NASA under grant NNX16AB76G. T.L.C. acknowledges support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement number 792848 (PULSATION). This work was supported by FCT/MCTES through national funds (PIDDAC) by means of grant UID/FIS/04434/2019. K.J.B., S.H., J.S.K. and N.T. are supported by the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement number 338251 (StellarAges). E.C. is funded by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement number 664931. L.G.-C. acknowledges support from the MINECO FPI-SO doctoral research project SEV-2015-0548-17-2 and predoctoral contract BES-2017-082610. P.G. is supported by the German space agency (Deutsches Zentrum für Luft- und Raumfahrt) under PLATO data grant 50OO1501. R.K. acknowledges support from the UK Science and Technology Facilities Council (STFC), under consolidated grant ST/L000733/1. M.S.L. is supported by the Carlsberg Foundation (grant agreement number CF17-076). Z.C.O., S.O. and M.Y. acknowledge support from the Scientific and Technological Research Council of Turkey (TÜBİTAK:118F352). S.M. acknowledges support from the Spanish ministry through the Ramon y Cajal fellowship number RYC-2015-17697. T.S.R. acknowledges financial support from Premiale 2015 MITiC (PI B. Garilli). R.Sz. acknowledges the support from NKFIH grant project No. K-115709, and the Lendület program of the Hungarian Academy of Science (project number 2018-7/2019). J.T. acknowledges support was provided by NASA through the NASA Hubble Fellowship grant number 51424 awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555. This work was supported by FEDER through COMPETE2020 (POCI-01-0145-FEDER-030389. A.M.B. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 749962 (project THOT). A.M. and P.R. acknowledge the support of the Government of India, Department of Atomic Energy, under Project No. 12-R&D-TFR-6.04-0600. K.J.B. is an NSF Astronomy and Astrophysics Postdoctoral Fellow and DIRAC Fellow. article_processing_charge: No article_type: letter_note author: - first_name: William J. full_name: Chaplin, William J. last_name: Chaplin - first_name: Aldo M. full_name: Serenelli, Aldo M. last_name: Serenelli - first_name: Andrea full_name: Miglio, Andrea last_name: Miglio - first_name: Thierry full_name: Morel, Thierry last_name: Morel - first_name: J. Ted full_name: Mackereth, J. Ted last_name: Mackereth - first_name: Fiorenzo full_name: Vincenzo, Fiorenzo last_name: Vincenzo - first_name: Hans full_name: Kjeldsen, Hans last_name: Kjeldsen - first_name: Sarbani full_name: Basu, Sarbani last_name: Basu - first_name: Warrick H. full_name: Ball, Warrick H. last_name: Ball - first_name: Amalie full_name: Stokholm, Amalie last_name: Stokholm - first_name: Kuldeep full_name: Verma, Kuldeep last_name: Verma - first_name: Jakob Rørsted full_name: Mosumgaard, Jakob Rørsted last_name: Mosumgaard - first_name: Victor full_name: Silva Aguirre, Victor last_name: Silva Aguirre - first_name: Anwesh full_name: Mazumdar, Anwesh last_name: Mazumdar - first_name: Pritesh full_name: Ranadive, Pritesh last_name: Ranadive - first_name: H. M. full_name: Antia, H. M. last_name: Antia - first_name: Yveline full_name: Lebreton, Yveline last_name: Lebreton - first_name: Joel full_name: Ong, Joel last_name: Ong - first_name: Thierry full_name: Appourchaux, Thierry last_name: Appourchaux - first_name: Timothy R. full_name: Bedding, Timothy R. last_name: Bedding - first_name: Jørgen full_name: Christensen-Dalsgaard, Jørgen last_name: Christensen-Dalsgaard - first_name: Orlagh full_name: Creevey, Orlagh last_name: Creevey - first_name: Rafael A. full_name: García, Rafael A. last_name: García - first_name: Rasmus full_name: Handberg, Rasmus last_name: Handberg - first_name: Daniel full_name: Huber, Daniel last_name: Huber - first_name: Steven D. full_name: Kawaler, Steven D. last_name: Kawaler - first_name: Mikkel N. full_name: Lund, Mikkel N. last_name: Lund - first_name: Travis S. full_name: Metcalfe, Travis S. last_name: Metcalfe - first_name: Keivan G. full_name: Stassun, Keivan G. last_name: Stassun - first_name: Michäel full_name: Bazot, Michäel last_name: Bazot - first_name: Paul G. full_name: Beck, Paul G. last_name: Beck - first_name: Keaton J. full_name: Bell, Keaton J. last_name: Bell - first_name: Maria full_name: Bergemann, Maria last_name: Bergemann - first_name: Derek L. full_name: Buzasi, Derek L. last_name: Buzasi - first_name: Othman full_name: Benomar, Othman last_name: Benomar - first_name: Diego full_name: Bossini, Diego last_name: Bossini - first_name: Lisa Annabelle full_name: Bugnet, Lisa Annabelle id: d9edb345-f866-11ec-9b37-d119b5234501 last_name: Bugnet orcid: 0000-0003-0142-4000 - first_name: Tiago L. full_name: Campante, Tiago L. last_name: Campante - first_name: Zeynep Çelik full_name: Orhan, Zeynep Çelik last_name: Orhan - first_name: Enrico full_name: Corsaro, Enrico last_name: Corsaro - first_name: Lucía full_name: González-Cuesta, Lucía last_name: González-Cuesta - first_name: Guy R. full_name: Davies, Guy R. last_name: Davies - first_name: Maria Pia full_name: Di Mauro, Maria Pia last_name: Di Mauro - first_name: Ricky full_name: Egeland, Ricky last_name: Egeland - first_name: Yvonne P. full_name: Elsworth, Yvonne P. last_name: Elsworth - first_name: Patrick full_name: Gaulme, Patrick last_name: Gaulme - first_name: Hamed full_name: Ghasemi, Hamed last_name: Ghasemi - first_name: Zhao full_name: Guo, Zhao last_name: Guo - first_name: Oliver J. full_name: Hall, Oliver J. last_name: Hall - first_name: Amir full_name: Hasanzadeh, Amir last_name: Hasanzadeh - first_name: Saskia full_name: Hekker, Saskia last_name: Hekker - first_name: Rachel full_name: Howe, Rachel last_name: Howe - first_name: Jon M. full_name: Jenkins, Jon M. last_name: Jenkins - first_name: Antonio full_name: Jiménez, Antonio last_name: Jiménez - first_name: René full_name: Kiefer, René last_name: Kiefer - first_name: James S. full_name: Kuszlewicz, James S. last_name: Kuszlewicz - first_name: Thomas full_name: Kallinger, Thomas last_name: Kallinger - first_name: David W. full_name: Latham, David W. last_name: Latham - first_name: Mia S. full_name: Lundkvist, Mia S. last_name: Lundkvist - first_name: Savita full_name: Mathur, Savita last_name: Mathur - first_name: Josefina full_name: Montalbán, Josefina last_name: Montalbán - first_name: Benoit full_name: Mosser, Benoit last_name: Mosser - first_name: Andres Moya full_name: Bedón, Andres Moya last_name: Bedón - first_name: Martin Bo full_name: Nielsen, Martin Bo last_name: Nielsen - first_name: Sibel full_name: Örtel, Sibel last_name: Örtel - first_name: Ben M. full_name: Rendle, Ben M. last_name: Rendle - first_name: George R. full_name: Ricker, George R. last_name: Ricker - first_name: Thaíse S. full_name: Rodrigues, Thaíse S. last_name: Rodrigues - first_name: Ian W. full_name: Roxburgh, Ian W. last_name: Roxburgh - first_name: Hossein full_name: Safari, Hossein last_name: Safari - first_name: Mathew full_name: Schofield, Mathew last_name: Schofield - first_name: Sara full_name: Seager, Sara last_name: Seager - first_name: Barry full_name: Smalley, Barry last_name: Smalley - first_name: Dennis full_name: Stello, Dennis last_name: Stello - first_name: Róbert full_name: Szabó, Róbert last_name: Szabó - first_name: Jamie full_name: Tayar, Jamie last_name: Tayar - first_name: Nathalie full_name: Themeßl, Nathalie last_name: Themeßl - first_name: Alexandra E. L. full_name: Thomas, Alexandra E. L. last_name: Thomas - first_name: Roland K. full_name: Vanderspek, Roland K. last_name: Vanderspek - first_name: Walter E. full_name: van Rossem, Walter E. last_name: van Rossem - first_name: Mathieu full_name: Vrard, Mathieu last_name: Vrard - first_name: Achim full_name: Weiss, Achim last_name: Weiss - first_name: Timothy R. full_name: White, Timothy R. last_name: White - first_name: Joshua N. full_name: Winn, Joshua N. last_name: Winn - first_name: Mutlu full_name: Yıldız, Mutlu last_name: Yıldız citation: ama: Chaplin WJ, Serenelli AM, Miglio A, et al. Age dating of an early Milky Way merger via asteroseismology of the naked-eye star ν Indi. Nature Astronomy. 2020;4(4):382-389. doi:10.1038/s41550-019-0975-9 apa: Chaplin, W. J., Serenelli, A. M., Miglio, A., Morel, T., Mackereth, J. T., Vincenzo, F., … Yıldız, M. (2020). Age dating of an early Milky Way merger via asteroseismology of the naked-eye star ν Indi. Nature Astronomy. Springer Nature. https://doi.org/10.1038/s41550-019-0975-9 chicago: Chaplin, William J., Aldo M. Serenelli, Andrea Miglio, Thierry Morel, J. Ted Mackereth, Fiorenzo Vincenzo, Hans Kjeldsen, et al. “Age Dating of an Early Milky Way Merger via Asteroseismology of the Naked-Eye Star ν Indi.” Nature Astronomy. Springer Nature, 2020. https://doi.org/10.1038/s41550-019-0975-9. ieee: W. J. Chaplin et al., “Age dating of an early Milky Way merger via asteroseismology of the naked-eye star ν Indi,” Nature Astronomy, vol. 4, no. 4. Springer Nature, pp. 382–389, 2020. ista: Chaplin WJ, Serenelli AM, Miglio A, Morel T, Mackereth JT, Vincenzo F, Kjeldsen H, Basu S, Ball WH, Stokholm A, Verma K, Mosumgaard JR, Silva Aguirre V, Mazumdar A, Ranadive P, Antia HM, Lebreton Y, Ong J, Appourchaux T, Bedding TR, Christensen-Dalsgaard J, Creevey O, García RA, Handberg R, Huber D, Kawaler SD, Lund MN, Metcalfe TS, Stassun KG, Bazot M, Beck PG, Bell KJ, Bergemann M, Buzasi DL, Benomar O, Bossini D, Bugnet LA, Campante TL, Orhan ZÇ, Corsaro E, González-Cuesta L, Davies GR, Di Mauro MP, Egeland R, Elsworth YP, Gaulme P, Ghasemi H, Guo Z, Hall OJ, Hasanzadeh A, Hekker S, Howe R, Jenkins JM, Jiménez A, Kiefer R, Kuszlewicz JS, Kallinger T, Latham DW, Lundkvist MS, Mathur S, Montalbán J, Mosser B, Bedón AM, Nielsen MB, Örtel S, Rendle BM, Ricker GR, Rodrigues TS, Roxburgh IW, Safari H, Schofield M, Seager S, Smalley B, Stello D, Szabó R, Tayar J, Themeßl N, Thomas AEL, Vanderspek RK, van Rossem WE, Vrard M, Weiss A, White TR, Winn JN, Yıldız M. 2020. Age dating of an early Milky Way merger via asteroseismology of the naked-eye star ν Indi. Nature Astronomy. 4(4), 382–389. mla: Chaplin, William J., et al. “Age Dating of an Early Milky Way Merger via Asteroseismology of the Naked-Eye Star ν Indi.” Nature Astronomy, vol. 4, no. 4, Springer Nature, 2020, pp. 382–89, doi:10.1038/s41550-019-0975-9. short: W.J. Chaplin, A.M. Serenelli, A. Miglio, T. Morel, J.T. Mackereth, F. Vincenzo, H. Kjeldsen, S. Basu, W.H. Ball, A. Stokholm, K. Verma, J.R. Mosumgaard, V. Silva Aguirre, A. Mazumdar, P. Ranadive, H.M. Antia, Y. Lebreton, J. Ong, T. Appourchaux, T.R. Bedding, J. Christensen-Dalsgaard, O. Creevey, R.A. García, R. Handberg, D. Huber, S.D. Kawaler, M.N. Lund, T.S. Metcalfe, K.G. Stassun, M. Bazot, P.G. Beck, K.J. Bell, M. Bergemann, D.L. Buzasi, O. Benomar, D. Bossini, L.A. Bugnet, T.L. Campante, Z.Ç. Orhan, E. Corsaro, L. González-Cuesta, G.R. Davies, M.P. Di Mauro, R. Egeland, Y.P. Elsworth, P. Gaulme, H. Ghasemi, Z. Guo, O.J. Hall, A. Hasanzadeh, S. Hekker, R. Howe, J.M. Jenkins, A. Jiménez, R. Kiefer, J.S. Kuszlewicz, T. Kallinger, D.W. Latham, M.S. Lundkvist, S. Mathur, J. Montalbán, B. Mosser, A.M. Bedón, M.B. Nielsen, S. Örtel, B.M. Rendle, G.R. Ricker, T.S. Rodrigues, I.W. Roxburgh, H. Safari, M. Schofield, S. Seager, B. Smalley, D. Stello, R. Szabó, J. Tayar, N. Themeßl, A.E.L. Thomas, R.K. Vanderspek, W.E. van Rossem, M. Vrard, A. Weiss, T.R. White, J.N. Winn, M. Yıldız, Nature Astronomy 4 (2020) 382–389. date_created: 2022-07-18T13:36:19Z date_published: 2020-04-01T00:00:00Z date_updated: 2022-08-22T07:08:29Z day: '01' doi: 10.1038/s41550-019-0975-9 extern: '1' external_id: arxiv: - '2001.04653' intvolume: ' 4' issue: '4' keyword: - Astronomy and Astrophysics language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2001.04653 month: '04' oa: 1 oa_version: Preprint page: 382-389 publication: Nature Astronomy publication_identifier: eissn: - 2397-3366 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Age dating of an early Milky Way merger via asteroseismology of the naked-eye star ν Indi type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 4 year: '2020' ... --- _id: '11612' abstract: - lang: eng text: Since the onset of the "space revolution" of high-precision high-cadence photometry, asteroseismology has been demonstrated as a powerful tool for informing Galactic archeology investigations. The launch of the NASA Transiting Exoplanet Survey Satellite (TESS) mission has enabled seismic-based inferences to go full sky—providing a clear advantage for large ensemble studies of the different Milky Way components. Here we demonstrate its potential for investigating the Galaxy by carrying out the first asteroseismic ensemble study of red giant stars observed by TESS. We use a sample of 25 stars for which we measure their global asteroseimic observables and estimate their fundamental stellar properties, such as radius, mass, and age. Significant improvements are seen in the uncertainties of our estimates when combining seismic observables from TESS with astrometric measurements from the Gaia mission compared to when the seismology and astrometry are applied separately. Specifically, when combined we show that stellar radii can be determined to a precision of a few percent, masses to 5%–10%, and ages to the 20% level. This is comparable to the precision typically obtained using end-of-mission Kepler data. acknowledgement: 'This Letter includes data collected by the TESS mission, which are publicly available from the Mikulski Archive for Space Telescopes (MAST). Funding for the TESS mission is provided by NASA''s Science Mission directorate. Funding for the TESS Asteroseismic Science Operations Centre is provided by the Danish National Research Foundation (grant agreement No. DNRF106), ESA PRODEX (PEA 4000119301), and Stellar Astrophysics Centre (SAC) at Aarhus University. V.S.A. acknowledges support from the Independent Research Fund Denmark (Research grant 7027-00096B). D.B. is supported in the form of work contract FCT/MCTES through national funds and by FEDER through COMPETE2020 in connection to these grants: UID/FIS/04434/2019; PTDC/FIS-AST/30389/2017 & POCI-01-0145-FEDER-030389. L.B., R.A.G., and B.M. acknowledge the support from the CNES/PLATO grant. D.B. acknowledges NASA grant NNX16AB76G. T.L.C. acknowledges support from the European Union''s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 792848 (PULSATION). This work was supported by FCT/MCTES through national funds (UID/FIS/04434/2019). E.C. is funded by the European Union''s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 664931. R.H. and M.N.L. acknowledge the support of the ESA PRODEX programme. T.S.R. acknowledges financial support from Premiale 2015 MITiC (PI B. Garilli). K.J.B. is supported by the National Science Foundation under Award AST-1903828. M.S.L. is supported by the Carlsberg Foundation (grant agreement No. CF17-0760). M.C. is funded by FCT//MCTES through national funds and by FEDER through COMPETE2020 through these grants: UID/FIS/04434/2019, PTDC/FIS-AST/30389/2017 & POCI-01-0145-FEDER-030389, CEECIND/02619/2017. The research leading to the presented results has received funding from the European Research Council under the European Community''s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no 338251 (StellarAges). A.M. acknowledges support from the European Research Council Consolidator Grant funding scheme (project ASTEROCHRONOMETRY, grant agreement No. 772293, http://www.asterochronometry.eu). A.M.S. is partially supported by MINECO grant ESP2017-82674-R. J.C.S. acknowledges funding support from Spanish public funds for research under projects ESP2017-87676-2-2, and from project RYC-2012-09913 under the ''Ramón y Cajal'' program of the Spanish Ministry of Science and Education. Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center for the production of the SPOC data products.' article_number: L34 article_processing_charge: No article_type: original author: - first_name: Víctor Silva full_name: Aguirre, Víctor Silva last_name: Aguirre - first_name: Dennis full_name: Stello, Dennis last_name: Stello - first_name: Amalie full_name: Stokholm, Amalie last_name: Stokholm - first_name: Jakob R. full_name: Mosumgaard, Jakob R. last_name: Mosumgaard - first_name: Warrick H. full_name: Ball, Warrick H. last_name: Ball - first_name: Sarbani full_name: Basu, Sarbani last_name: Basu - first_name: Diego full_name: Bossini, Diego last_name: Bossini - first_name: Lisa Annabelle full_name: Bugnet, Lisa Annabelle id: d9edb345-f866-11ec-9b37-d119b5234501 last_name: Bugnet orcid: 0000-0003-0142-4000 - first_name: Derek full_name: Buzasi, Derek last_name: Buzasi - first_name: Tiago L. full_name: Campante, Tiago L. last_name: Campante - first_name: Lindsey full_name: Carboneau, Lindsey last_name: Carboneau - first_name: William J. full_name: Chaplin, William J. last_name: Chaplin - first_name: Enrico full_name: Corsaro, Enrico last_name: Corsaro - first_name: Guy R. full_name: Davies, Guy R. last_name: Davies - first_name: Yvonne full_name: Elsworth, Yvonne last_name: Elsworth - first_name: Rafael A. full_name: García, Rafael A. last_name: García - first_name: Patrick full_name: Gaulme, Patrick last_name: Gaulme - first_name: Oliver J. full_name: Hall, Oliver J. last_name: Hall - first_name: Rasmus full_name: Handberg, Rasmus last_name: Handberg - first_name: Marc full_name: Hon, Marc last_name: Hon - first_name: Thomas full_name: Kallinger, Thomas last_name: Kallinger - first_name: Liu full_name: Kang, Liu last_name: Kang - first_name: Mikkel N. full_name: Lund, Mikkel N. last_name: Lund - first_name: Savita full_name: Mathur, Savita last_name: Mathur - first_name: Alexey full_name: Mints, Alexey last_name: Mints - first_name: Benoit full_name: Mosser, Benoit last_name: Mosser - first_name: Zeynep full_name: Çelik Orhan, Zeynep last_name: Çelik Orhan - first_name: Thaíse S. full_name: Rodrigues, Thaíse S. last_name: Rodrigues - first_name: Mathieu full_name: Vrard, Mathieu last_name: Vrard - first_name: Mutlu full_name: Yıldız, Mutlu last_name: Yıldız - first_name: Joel C. full_name: Zinn, Joel C. last_name: Zinn - first_name: Sibel full_name: Örtel, Sibel last_name: Örtel - first_name: Paul G. full_name: Beck, Paul G. last_name: Beck - first_name: Keaton J. full_name: Bell, Keaton J. last_name: Bell - first_name: Zhao full_name: Guo, Zhao last_name: Guo - first_name: Chen full_name: Jiang, Chen last_name: Jiang - first_name: James S. full_name: Kuszlewicz, James S. last_name: Kuszlewicz - first_name: Charles A. full_name: Kuehn, Charles A. last_name: Kuehn - first_name: Tanda full_name: Li, Tanda last_name: Li - first_name: Mia S. full_name: Lundkvist, Mia S. last_name: Lundkvist - first_name: Marc full_name: Pinsonneault, Marc last_name: Pinsonneault - first_name: Jamie full_name: Tayar, Jamie last_name: Tayar - first_name: Margarida S. full_name: Cunha, Margarida S. last_name: Cunha - first_name: Saskia full_name: Hekker, Saskia last_name: Hekker - first_name: Daniel full_name: Huber, Daniel last_name: Huber - first_name: Andrea full_name: Miglio, Andrea last_name: Miglio - first_name: Mario J. P. full_name: F. G. Monteiro, Mario J. P. last_name: F. G. Monteiro - first_name: Ditte full_name: Slumstrup, Ditte last_name: Slumstrup - first_name: Mark L. full_name: Winther, Mark L. last_name: Winther - first_name: George full_name: Angelou, George last_name: Angelou - first_name: Othman full_name: Benomar, Othman last_name: Benomar - first_name: Attila full_name: Bódi, Attila last_name: Bódi - first_name: Bruno L. full_name: De Moura, Bruno L. last_name: De Moura - first_name: Sébastien full_name: Deheuvels, Sébastien last_name: Deheuvels - first_name: Aliz full_name: Derekas, Aliz last_name: Derekas - first_name: Maria Pia full_name: Di Mauro, Maria Pia last_name: Di Mauro - first_name: Marc-Antoine full_name: Dupret, Marc-Antoine last_name: Dupret - first_name: Antonio full_name: Jiménez, Antonio last_name: Jiménez - first_name: Yveline full_name: Lebreton, Yveline last_name: Lebreton - first_name: Jaymie full_name: Matthews, Jaymie last_name: Matthews - first_name: Nicolas full_name: Nardetto, Nicolas last_name: Nardetto - first_name: Jose D. full_name: do Nascimento, Jose D. last_name: do Nascimento - first_name: Filipe full_name: Pereira, Filipe last_name: Pereira - first_name: Luisa F. full_name: Rodríguez Díaz, Luisa F. last_name: Rodríguez Díaz - first_name: Aldo M. full_name: Serenelli, Aldo M. last_name: Serenelli - first_name: Emanuele full_name: Spitoni, Emanuele last_name: Spitoni - first_name: Edita full_name: Stonkutė, Edita last_name: Stonkutė - first_name: Juan Carlos full_name: Suárez, Juan Carlos last_name: Suárez - first_name: Robert full_name: Szabó, Robert last_name: Szabó - first_name: Vincent full_name: Van Eylen, Vincent last_name: Van Eylen - first_name: Rita full_name: Ventura, Rita last_name: Ventura - first_name: Kuldeep full_name: Verma, Kuldeep last_name: Verma - first_name: Achim full_name: Weiss, Achim last_name: Weiss - first_name: Tao full_name: Wu, Tao last_name: Wu - first_name: Thomas full_name: Barclay, Thomas last_name: Barclay - first_name: Jørgen full_name: Christensen-Dalsgaard, Jørgen last_name: Christensen-Dalsgaard - first_name: Jon M. full_name: Jenkins, Jon M. last_name: Jenkins - first_name: Hans full_name: Kjeldsen, Hans last_name: Kjeldsen - first_name: George R. full_name: Ricker, George R. last_name: Ricker - first_name: Sara full_name: Seager, Sara last_name: Seager - first_name: Roland full_name: Vanderspek, Roland last_name: Vanderspek citation: ama: 'Aguirre VS, Stello D, Stokholm A, et al. Detection and characterization of oscillating red giants: First results from the TESS satellite. The Astrophysical Journal Letters. 2020;889(2). doi:10.3847/2041-8213/ab6443' apa: 'Aguirre, V. S., Stello, D., Stokholm, A., Mosumgaard, J. R., Ball, W. H., Basu, S., … Vanderspek, R. (2020). Detection and characterization of oscillating red giants: First results from the TESS satellite. The Astrophysical Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ab6443' chicago: 'Aguirre, Víctor Silva, Dennis Stello, Amalie Stokholm, Jakob R. Mosumgaard, Warrick H. Ball, Sarbani Basu, Diego Bossini, et al. “Detection and Characterization of Oscillating Red Giants: First Results from the TESS Satellite.” The Astrophysical Journal Letters. IOP Publishing, 2020. https://doi.org/10.3847/2041-8213/ab6443.' ieee: 'V. S. Aguirre et al., “Detection and characterization of oscillating red giants: First results from the TESS satellite,” The Astrophysical Journal Letters, vol. 889, no. 2. IOP Publishing, 2020.' ista: 'Aguirre VS, Stello D, Stokholm A, Mosumgaard JR, Ball WH, Basu S, Bossini D, Bugnet LA, Buzasi D, Campante TL, Carboneau L, Chaplin WJ, Corsaro E, Davies GR, Elsworth Y, García RA, Gaulme P, Hall OJ, Handberg R, Hon M, Kallinger T, Kang L, Lund MN, Mathur S, Mints A, Mosser B, Çelik Orhan Z, Rodrigues TS, Vrard M, Yıldız M, Zinn JC, Örtel S, Beck PG, Bell KJ, Guo Z, Jiang C, Kuszlewicz JS, Kuehn CA, Li T, Lundkvist MS, Pinsonneault M, Tayar J, Cunha MS, Hekker S, Huber D, Miglio A, F. G. Monteiro MJP, Slumstrup D, Winther ML, Angelou G, Benomar O, Bódi A, De Moura BL, Deheuvels S, Derekas A, Di Mauro MP, Dupret M-A, Jiménez A, Lebreton Y, Matthews J, Nardetto N, do Nascimento JD, Pereira F, Rodríguez Díaz LF, Serenelli AM, Spitoni E, Stonkutė E, Suárez JC, Szabó R, Van Eylen V, Ventura R, Verma K, Weiss A, Wu T, Barclay T, Christensen-Dalsgaard J, Jenkins JM, Kjeldsen H, Ricker GR, Seager S, Vanderspek R. 2020. Detection and characterization of oscillating red giants: First results from the TESS satellite. The Astrophysical Journal Letters. 889(2), L34.' mla: 'Aguirre, Víctor Silva, et al. “Detection and Characterization of Oscillating Red Giants: First Results from the TESS Satellite.” The Astrophysical Journal Letters, vol. 889, no. 2, L34, IOP Publishing, 2020, doi:10.3847/2041-8213/ab6443.' short: V.S. Aguirre, D. Stello, A. Stokholm, J.R. Mosumgaard, W.H. Ball, S. Basu, D. Bossini, L.A. Bugnet, D. Buzasi, T.L. Campante, L. Carboneau, W.J. Chaplin, E. Corsaro, G.R. Davies, Y. Elsworth, R.A. García, P. Gaulme, O.J. Hall, R. Handberg, M. Hon, T. Kallinger, L. Kang, M.N. Lund, S. Mathur, A. Mints, B. Mosser, Z. Çelik Orhan, T.S. Rodrigues, M. Vrard, M. Yıldız, J.C. Zinn, S. Örtel, P.G. Beck, K.J. Bell, Z. Guo, C. Jiang, J.S. Kuszlewicz, C.A. Kuehn, T. Li, M.S. Lundkvist, M. Pinsonneault, J. Tayar, M.S. Cunha, S. Hekker, D. Huber, A. Miglio, M.J.P. F. G. Monteiro, D. Slumstrup, M.L. Winther, G. Angelou, O. Benomar, A. Bódi, B.L. De Moura, S. Deheuvels, A. Derekas, M.P. Di Mauro, M.-A. Dupret, A. Jiménez, Y. Lebreton, J. Matthews, N. Nardetto, J.D. do Nascimento, F. Pereira, L.F. Rodríguez Díaz, A.M. Serenelli, E. Spitoni, E. Stonkutė, J.C. Suárez, R. Szabó, V. Van Eylen, R. Ventura, K. Verma, A. Weiss, T. Wu, T. Barclay, J. Christensen-Dalsgaard, J.M. Jenkins, H. Kjeldsen, G.R. Ricker, S. Seager, R. Vanderspek, The Astrophysical Journal Letters 889 (2020). date_created: 2022-07-18T13:52:54Z date_published: 2020-02-01T00:00:00Z date_updated: 2022-08-22T07:25:51Z day: '01' doi: 10.3847/2041-8213/ab6443 extern: '1' external_id: arxiv: - '1912.07604' intvolume: ' 889' issue: '2' keyword: - Space and Planetary Science - Astronomy and Astrophysics language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1912.07604 month: '02' oa: 1 oa_version: Preprint publication: The Astrophysical Journal Letters publication_identifier: eissn: - 1538-4357 issn: - 0004-637X publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: 'Detection and characterization of oscillating red giants: First results from the TESS satellite' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 889 year: '2020' ... --- _id: '11622' abstract: - lang: eng text: 'The recent discovery of low-amplitude dipolar oscillation mixed modes in massive red giants indicates the presence of a missing physical process inside their cores. Stars more massive than ∼ 1.3 M⊙ are known to develop a convective core during the main-sequence: the dynamo process triggered by this convection could be the origin of a strong magnetic field inside the core of the star, trapped when it becomes stably stratified and for the rest of its evolution. The presence of highly magnetized white dwarfs strengthens the hypothesis of buried fossil magnetic fields inside the core of evolved low-mass stars. If such a fossil field exists, it should affect the mixed modes of red giants as they are sensitive to processes affecting the deepest layers of these stars. The impact of a magnetic field on dipolar oscillations modes was one of Pr. Michael J. Thompson’s research topics during the 90s when preparing the helioseismic SoHO space mission. As the detection of gravity modes in the Sun is still controversial, the investigation of the solar oscillation modes did not provide any hint of the existence of a magnetic field in the solar radiative core. Today we have access to the core of evolved stars thanks to the asteroseismic observation of mixed modes from CoRoT, Kepler, K2 and TESS missions. The idea of applying and generalizing the work done for the Sun came from discussions with Pr. Michael Thompson in early 2018 before we lost him. Following the path we drew together, we theoretically investigate the effect of a stable axisymmetric mixed poloidal and toroidal magnetic field, aligned with the rotation axis of the star, on the mixed modes frequencies of a typical evolved low-mass star. This enables us to estimate the magnetic perturbations to the eigenfrequencies of mixed dipolar modes, depending on the magnetic field strength and the evolutionary state of the star. We conclude that strong magnetic fields of ∼ 1MG should perturb the mixed-mode frequency pattern enough for its effects to be detectable inside current asteroseismic data.' acknowledgement: The authors of this work acknowledge the support received from the PLATO CNES grant, the National Aeronautics and Space Administration under Grant NNX15AF13G, by the National Science Foundation grant AST-1411685, the Ramon y Cajal fellowship number RYC-2015-17697, the ERC SPIRE grant (647383), and the Fundation L’Oréal-Unesco-Académie des sciences. alternative_title: - Astrophysics and Space Science Proceedings article_processing_charge: No author: - first_name: Lisa Annabelle full_name: Bugnet, Lisa Annabelle id: d9edb345-f866-11ec-9b37-d119b5234501 last_name: Bugnet orcid: 0000-0003-0142-4000 - first_name: V. full_name: Prat, V. last_name: Prat - first_name: S. full_name: Mathis, S. last_name: Mathis - first_name: R. A. full_name: García, R. A. last_name: García - first_name: S. full_name: Mathur, S. last_name: Mathur - first_name: K. full_name: Augustson, K. last_name: Augustson - first_name: C. full_name: Neiner, C. last_name: Neiner - first_name: M. J. full_name: Thompson, M. J. last_name: Thompson citation: ama: 'Bugnet LA, Prat V, Mathis S, et al. The impact of a fossil magnetic field on dipolar mixed-mode frequencies in sub- and red-giant stars. In: Monteiro M, Garcia RA, Christensen-Dalsgaard J, McIntosh SW, eds. Dynamics of the Sun and Stars. Vol 57. 1st ed. ASSSP. Cham: Springer Nature; 2020:251-257. doi:10.1007/978-3-030-55336-4_33' apa: 'Bugnet, L. A., Prat, V., Mathis, S., García, R. A., Mathur, S., Augustson, K., … Thompson, M. J. (2020). The impact of a fossil magnetic field on dipolar mixed-mode frequencies in sub- and red-giant stars. In M. Monteiro, R. A. Garcia, J. Christensen-Dalsgaard, & S. W. McIntosh (Eds.), Dynamics of the Sun and Stars (1st ed., Vol. 57, pp. 251–257). Cham: Springer Nature. https://doi.org/10.1007/978-3-030-55336-4_33' chicago: 'Bugnet, Lisa Annabelle, V. Prat, S. Mathis, R. A. García, S. Mathur, K. Augustson, C. Neiner, and M. J. Thompson. “The Impact of a Fossil Magnetic Field on Dipolar Mixed-Mode Frequencies in Sub- and Red-Giant Stars.” In Dynamics of the Sun and Stars, edited by Mario Monteiro, Rafael A Garcia, Jorgen Christensen-Dalsgaard, and Scott W McIntosh, 1st ed., 57:251–57. ASSSP. Cham: Springer Nature, 2020. https://doi.org/10.1007/978-3-030-55336-4_33.' ieee: 'L. A. Bugnet et al., “The impact of a fossil magnetic field on dipolar mixed-mode frequencies in sub- and red-giant stars,” in Dynamics of the Sun and Stars, 1st ed., vol. 57, M. Monteiro, R. A. Garcia, J. Christensen-Dalsgaard, and S. W. McIntosh, Eds. Cham: Springer Nature, 2020, pp. 251–257.' ista: 'Bugnet LA, Prat V, Mathis S, García RA, Mathur S, Augustson K, Neiner C, Thompson MJ. 2020.The impact of a fossil magnetic field on dipolar mixed-mode frequencies in sub- and red-giant stars. In: Dynamics of the Sun and Stars. Astrophysics and Space Science Proceedings, vol. 57, 251–257.' mla: Bugnet, Lisa Annabelle, et al. “The Impact of a Fossil Magnetic Field on Dipolar Mixed-Mode Frequencies in Sub- and Red-Giant Stars.” Dynamics of the Sun and Stars, edited by Mario Monteiro et al., 1st ed., vol. 57, Springer Nature, 2020, pp. 251–57, doi:10.1007/978-3-030-55336-4_33. short: L.A. Bugnet, V. Prat, S. Mathis, R.A. García, S. Mathur, K. Augustson, C. Neiner, M.J. Thompson, in:, M. Monteiro, R.A. Garcia, J. Christensen-Dalsgaard, S.W. McIntosh (Eds.), Dynamics of the Sun and Stars, 1st ed., Springer Nature, Cham, 2020, pp. 251–257. date_created: 2022-07-19T08:25:41Z date_published: 2020-12-19T00:00:00Z date_updated: 2022-08-22T08:07:42Z day: '19' doi: 10.1007/978-3-030-55336-4_33 edition: '1' editor: - first_name: Mario full_name: Monteiro, Mario last_name: Monteiro - first_name: Rafael A full_name: Garcia, Rafael A last_name: Garcia - first_name: Jorgen full_name: Christensen-Dalsgaard, Jorgen last_name: Christensen-Dalsgaard - first_name: Scott W full_name: McIntosh, Scott W last_name: McIntosh extern: '1' external_id: arxiv: - '2012.08684' intvolume: ' 57' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2012.08684 month: '12' oa: 1 oa_version: Preprint page: 251-257 place: Cham publication: Dynamics of the Sun and Stars publication_identifier: eisbn: - 978-3-030-55336-4 eissn: - 1570-6605 isbn: - 978-3-030-55335-7 issn: - 1570-6591 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' series_title: ASSSP status: public title: The impact of a fossil magnetic field on dipolar mixed-mode frequencies in sub- and red-giant stars type: book_chapter user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 57 year: '2020' ... --- _id: '11675' abstract: - lang: eng text: 'We consider the problems of maintaining an approximate maximum matching and an approximate minimum vertex cover in a dynamic graph undergoing a sequence of edge insertions/deletions. Starting with the seminal work of Onak and Rubinfeld (in: Proceedings of the ACM symposium on theory of computing (STOC), 2010), this problem has received significant attention in recent years. Very recently, extending the framework of Baswana et al. (in: Proceedings of the IEEE symposium on foundations of computer science (FOCS), 2011) , Solomon (in: Proceedings of the IEEE symposium on foundations of computer science (FOCS), 2016) gave a randomized dynamic algorithm for this problem that has an approximation ratio of 2 and an amortized update time of O(1) with high probability. This algorithm requires the assumption of an oblivious adversary, meaning that the future sequence of edge insertions/deletions in the graph cannot depend in any way on the algorithm’s past output. A natural way to remove the assumption on oblivious adversary is to give a deterministic dynamic algorithm for the same problem in O(1) update time. In this paper, we resolve this question. We present a new deterministic fully dynamic algorithm that maintains a O(1)-approximate minimum vertex cover and maximum fractional matching, with an amortized update time of O(1). Previously, the best deterministic algorithm for this problem was due to Bhattacharya et al. (in: Proceedings of the ACM-SIAM symposium on discrete algorithms (SODA), 2015); it had an approximation ratio of (2+ε) and an amortized update time of O(logn/ε2). Our result can be generalized to give a fully dynamic O(f3)-approximate algorithm with O(f2) amortized update time for the hypergraph vertex cover and fractional hypergraph matching problem, where every hyperedge has at most f vertices.' article_processing_charge: No article_type: original author: - first_name: Sayan full_name: Bhattacharya, Sayan last_name: Bhattacharya - first_name: Deeparnab full_name: Chakrabarty, Deeparnab last_name: Chakrabarty - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 citation: ama: Bhattacharya S, Chakrabarty D, Henzinger MH. Deterministic dynamic matching in O(1) update time. Algorithmica. 2020;82(4):1057-1080. doi:10.1007/s00453-019-00630-4 apa: Bhattacharya, S., Chakrabarty, D., & Henzinger, M. H. (2020). Deterministic dynamic matching in O(1) update time. Algorithmica. Springer Nature. https://doi.org/10.1007/s00453-019-00630-4 chicago: Bhattacharya, Sayan, Deeparnab Chakrabarty, and Monika H Henzinger. “Deterministic Dynamic Matching in O(1) Update Time.” Algorithmica. Springer Nature, 2020. https://doi.org/10.1007/s00453-019-00630-4. ieee: S. Bhattacharya, D. Chakrabarty, and M. H. Henzinger, “Deterministic dynamic matching in O(1) update time,” Algorithmica, vol. 82, no. 4. Springer Nature, pp. 1057–1080, 2020. ista: Bhattacharya S, Chakrabarty D, Henzinger MH. 2020. Deterministic dynamic matching in O(1) update time. Algorithmica. 82(4), 1057–1080. mla: Bhattacharya, Sayan, et al. “Deterministic Dynamic Matching in O(1) Update Time.” Algorithmica, vol. 82, no. 4, Springer Nature, 2020, pp. 1057–80, doi:10.1007/s00453-019-00630-4. short: S. Bhattacharya, D. Chakrabarty, M.H. Henzinger, Algorithmica 82 (2020) 1057–1080. date_created: 2022-07-27T14:31:06Z date_published: 2020-04-01T00:00:00Z date_updated: 2022-09-12T08:55:46Z day: '01' doi: 10.1007/s00453-019-00630-4 extern: '1' intvolume: ' 82' issue: '4' keyword: - Dynamic algorithms - Data structures - Graph algorithms - Matching - Vertex cover language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1007/s00453-019-00630-4 month: '04' oa: 1 oa_version: Published Version page: 1057-1080 publication: Algorithmica publication_identifier: eissn: - 1432-0541 issn: - 0178-4617 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Deterministic dynamic matching in O(1) update time type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 82 year: '2020' ... --- _id: '11674' abstract: - lang: eng text: In this paper, we study the problem of opening centers to cluster a set of clients in a metric space so as to minimize the sum of the costs of the centers and of the cluster radii, in a dynamic environment where clients arrive and depart, and the solution must be updated efficiently while remaining competitive with respect to the current optimal solution. We call this dynamic sum-of-radii clustering problem. We present a data structure that maintains a solution whose cost is within a constant factor of the cost of an optimal solution in metric spaces with bounded doubling dimension and whose worst-case update time is logarithmic in the parameters of the problem. article_processing_charge: No article_type: original author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 - first_name: Dariusz full_name: Leniowski, Dariusz last_name: Leniowski - first_name: Claire full_name: Mathieu, Claire last_name: Mathieu citation: ama: Henzinger MH, Leniowski D, Mathieu C. Dynamic clustering to minimize the sum of radii. Algorithmica. 2020;82(11):3183-3194. doi:10.1007/s00453-020-00721-7 apa: Henzinger, M. H., Leniowski, D., & Mathieu, C. (2020). Dynamic clustering to minimize the sum of radii. Algorithmica. Springer Nature. https://doi.org/10.1007/s00453-020-00721-7 chicago: Henzinger, Monika H, Dariusz Leniowski, and Claire Mathieu. “Dynamic Clustering to Minimize the Sum of Radii.” Algorithmica. Springer Nature, 2020. https://doi.org/10.1007/s00453-020-00721-7. ieee: M. H. Henzinger, D. Leniowski, and C. Mathieu, “Dynamic clustering to minimize the sum of radii,” Algorithmica, vol. 82, no. 11. Springer Nature, pp. 3183–3194, 2020. ista: Henzinger MH, Leniowski D, Mathieu C. 2020. Dynamic clustering to minimize the sum of radii. Algorithmica. 82(11), 3183–3194. mla: Henzinger, Monika H., et al. “Dynamic Clustering to Minimize the Sum of Radii.” Algorithmica, vol. 82, no. 11, Springer Nature, 2020, pp. 3183–94, doi:10.1007/s00453-020-00721-7. short: M.H. Henzinger, D. Leniowski, C. Mathieu, Algorithmica 82 (2020) 3183–3194. date_created: 2022-07-27T13:58:58Z date_published: 2020-11-01T00:00:00Z date_updated: 2022-09-12T08:50:14Z day: '01' doi: 10.1007/s00453-020-00721-7 extern: '1' external_id: arxiv: - '1707.02577' intvolume: ' 82' issue: '11' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.1707.02577 month: '11' oa: 1 oa_version: Preprint page: 3183-3194 publication: Algorithmica publication_identifier: eissn: - 1432-0541 issn: - 0178-4617 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Dynamic clustering to minimize the sum of radii type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 82 year: '2020' ... --- _id: '11818' abstract: - lang: eng text: "With input sizes becoming massive, coresets - small yet representative summary of the input - are relevant more than ever. A weighted set C_w that is a subset of the input is an ε-coreset if the cost of any feasible solution S with respect to C_w is within [1±ε] of the cost of S with respect to the original input. We give a very general technique to compute coresets in the fully-dynamic setting where input points can be added or deleted. Given a static (i.e., not dynamic) ε-coreset-construction algorithm that runs in time t(n, ε, λ) and computes a coreset of size s(n, ε, λ), where n is the number of input points and 1-λ is the success probability, we give a fully-dynamic algorithm that computes an ε-coreset with worst-case update time O((log n) ⋅ t(s(n, ε/log n, λ/n), ε/log n, λ/n)) (this bound is stated informally), where the success probability is 1-λ. Our technique is a fully-dynamic analog of the merge-and-reduce technique, which is due to Har-Peled and Mazumdar [Har-Peled and Mazumdar, 2004] and is based on a technique of Bentley and Saxe [Jon Louis Bentley and James B. Saxe, 1980], that applies to the insertion-only setting where points can only be added. Although, our space usage is O(n), our technique works in the presence of an adaptive adversary, and we show that Ω(n) space is required when adversary is adaptive.\r\nAs a concrete implication of our technique, using the result of Braverman et al. [{Braverman} et al., 2016], we get fully-dynamic ε-coreset-construction algorithms for k-median and k-means with worst-case update time O(ε^{-2} k² log⁵ n log³ k) and coreset size O(ε^{-2} k log n log² k) ignoring log log n and log(1/ε) factors and assuming that ε = Ω(1/poly(n)) and λ = Ω(1/poly(n)) (which are very weak assumptions made only to make these bounds easy to parse). This results in the first fully-dynamic constant-approximation algorithms for k-median and k-means with update times O(poly(k, log n, ε^{-1})). Specifically, the dependence on k is only quadratic, and the bounds are worst-case. The best previous bound for both problems was amortized O(nlog n) by Cohen-Addad et al. [Cohen-Addad et al., 2019] via randomized O(1)-coresets in O(n) space.\r\nWe also show that under the OMv conjecture [Monika Henzinger et al., 2015], a fully-dynamic (4 - δ)-approximation algorithm for k-means must either have an amortized update time of Ω(k^{1-γ}) or amortized query time of Ω(k^{2 - γ}), where γ > 0 is a constant." alternative_title: - LIPIcs article_number: '57' article_processing_charge: No author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 - first_name: Sagar full_name: Kale, Sagar last_name: Kale citation: ama: 'Henzinger MH, Kale S. Fully-dynamic coresets. In: 28th Annual European Symposium on Algorithms. Vol 173. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:10.4230/LIPIcs.ESA.2020.57' apa: 'Henzinger, M. H., & Kale, S. (2020). Fully-dynamic coresets. In 28th Annual European Symposium on Algorithms (Vol. 173). Pisa, Italy: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.ESA.2020.57' chicago: Henzinger, Monika H, and Sagar Kale. “Fully-Dynamic Coresets.” In 28th Annual European Symposium on Algorithms, Vol. 173. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. https://doi.org/10.4230/LIPIcs.ESA.2020.57. ieee: M. H. Henzinger and S. Kale, “Fully-dynamic coresets,” in 28th Annual European Symposium on Algorithms, Pisa, Italy, 2020, vol. 173. ista: 'Henzinger MH, Kale S. 2020. Fully-dynamic coresets. 28th Annual European Symposium on Algorithms. ESA: Annual European Symposium on Algorithms, LIPIcs, vol. 173, 57.' mla: Henzinger, Monika H., and Sagar Kale. “Fully-Dynamic Coresets.” 28th Annual European Symposium on Algorithms, vol. 173, 57, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:10.4230/LIPIcs.ESA.2020.57. short: M.H. Henzinger, S. Kale, in:, 28th Annual European Symposium on Algorithms, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. conference: end_date: 2020-09-09 location: Pisa, Italy name: 'ESA: Annual European Symposium on Algorithms' start_date: 2020-09-07 date_created: 2022-08-12T07:22:55Z date_published: 2020-08-26T00:00:00Z date_updated: 2023-02-14T09:29:51Z day: '26' doi: 10.4230/LIPIcs.ESA.2020.57 extern: '1' external_id: arxiv: - '2004.14891' intvolume: ' 173' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.4230/LIPIcs.ESA.2020.57 month: '08' oa: 1 oa_version: Published Version publication: 28th Annual European Symposium on Algorithms publication_identifier: isbn: - '9783959771627' issn: - 1868-8969 publication_status: published publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik quality_controlled: '1' scopus_import: '1' status: public title: Fully-dynamic coresets type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 173 year: '2020' ... --- _id: '11816' abstract: - lang: eng text: In recent years, significant advances have been made in the design and analysis of fully dynamic maximal matching algorithms. However, these theoretical results have received very little attention from the practical perspective. Few of the algorithms are implemented and tested on real datasets, and their practical potential is far from understood. In this paper, we attempt to bridge the gap between theory and practice that is currently observed for the fully dynamic maximal matching problem. We engineer several algorithms and empirically study those algorithms on an extensive set of dynamic instances. alternative_title: - LIPIcs article_number: '58' article_processing_charge: No author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 - first_name: Khan full_name: Shahbaz, Khan last_name: Shahbaz - first_name: Richard full_name: Paul, Richard last_name: Paul - first_name: Christian full_name: Schulz, Christian last_name: Schulz citation: ama: 'Henzinger MH, Shahbaz K, Paul R, Schulz C. Dynamic matching algorithms in practice. In: 8th Annual European Symposium on Algorithms. Vol 173. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:10.4230/LIPIcs.ESA.2020.58' apa: 'Henzinger, M. H., Shahbaz, K., Paul, R., & Schulz, C. (2020). Dynamic matching algorithms in practice. In 8th Annual European Symposium on Algorithms (Vol. 173). Pisa, Italy: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.ESA.2020.58' chicago: Henzinger, Monika H, Khan Shahbaz, Richard Paul, and Christian Schulz. “Dynamic Matching Algorithms in Practice.” In 8th Annual European Symposium on Algorithms, Vol. 173. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. https://doi.org/10.4230/LIPIcs.ESA.2020.58. ieee: M. H. Henzinger, K. Shahbaz, R. Paul, and C. Schulz, “Dynamic matching algorithms in practice,” in 8th Annual European Symposium on Algorithms, Pisa, Italy, 2020, vol. 173. ista: 'Henzinger MH, Shahbaz K, Paul R, Schulz C. 2020. Dynamic matching algorithms in practice. 8th Annual European Symposium on Algorithms. ESA: Annual European Symposium on Algorithms, LIPIcs, vol. 173, 58.' mla: Henzinger, Monika H., et al. “Dynamic Matching Algorithms in Practice.” 8th Annual European Symposium on Algorithms, vol. 173, 58, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:10.4230/LIPIcs.ESA.2020.58. short: M.H. Henzinger, K. Shahbaz, R. Paul, C. Schulz, in:, 8th Annual European Symposium on Algorithms, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. conference: end_date: 2020-09-09 location: Pisa, Italy name: 'ESA: Annual European Symposium on Algorithms' start_date: 2020-09-07 date_created: 2022-08-12T07:13:25Z date_published: 2020-08-26T00:00:00Z date_updated: 2023-02-14T08:57:55Z day: '26' doi: 10.4230/LIPIcs.ESA.2020.58 extern: '1' external_id: arxiv: - '2004.09099' intvolume: ' 173' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.4230/LIPIcs.ESA.2020.58 month: '08' oa: 1 oa_version: Published Version publication: 8th Annual European Symposium on Algorithms publication_identifier: isbn: - '9783959771627' issn: - 1868-8969 publication_status: published publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik quality_controlled: '1' scopus_import: '1' status: public title: Dynamic matching algorithms in practice type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 173 year: '2020' ... --- _id: '11824' abstract: - lang: eng text: "Independent set is a fundamental problem in combinatorial optimization. While in general graphs the problem is essentially inapproximable, for many important graph classes there are approximation algorithms known in the offline setting. These graph classes include interval graphs and geometric intersection graphs, where vertices correspond to intervals/geometric objects and an edge indicates that the two corresponding objects intersect.\r\nWe present dynamic approximation algorithms for independent set of intervals, hypercubes and hyperrectangles in d dimensions. They work in the fully dynamic model where each update inserts or deletes a geometric object. All our algorithms are deterministic and have worst-case update times that are polylogarithmic for constant d and ε>0, assuming that the coordinates of all input objects are in [0, N]^d and each of their edges has length at least 1. We obtain the following results:\r\n- For weighted intervals, we maintain a (1+ε)-approximate solution.\r\n- For d-dimensional hypercubes we maintain a (1+ε)2^d-approximate solution in the unweighted case and a O(2^d)-approximate solution in the weighted case. Also, we show that for maintaining an unweighted (1+ε)-approximate solution one needs polynomial update time for d ≥ 2 if the ETH holds.\r\n- For weighted d-dimensional hyperrectangles we present a dynamic algorithm with approximation ratio (1+ε)log^{d-1}N." alternative_title: - LIPIcs article_number: '51' article_processing_charge: No author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 - first_name: Stefan full_name: Neumann, Stefan last_name: Neumann - first_name: Andreas full_name: Wiese, Andreas last_name: Wiese citation: ama: 'Henzinger MH, Neumann S, Wiese A. Dynamic approximate maximum independent set of intervals, hypercubes and hyperrectangles. In: 36th International Symposium on Computational Geometry. Vol 164. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:10.4230/LIPIcs.SoCG.2020.51' apa: 'Henzinger, M. H., Neumann, S., & Wiese, A. (2020). Dynamic approximate maximum independent set of intervals, hypercubes and hyperrectangles. In 36th International Symposium on Computational Geometry (Vol. 164). Zurich, Switzerland: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.SoCG.2020.51' chicago: Henzinger, Monika H, Stefan Neumann, and Andreas Wiese. “Dynamic Approximate Maximum Independent Set of Intervals, Hypercubes and Hyperrectangles.” In 36th International Symposium on Computational Geometry, Vol. 164. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. https://doi.org/10.4230/LIPIcs.SoCG.2020.51. ieee: M. H. Henzinger, S. Neumann, and A. Wiese, “Dynamic approximate maximum independent set of intervals, hypercubes and hyperrectangles,” in 36th International Symposium on Computational Geometry, Zurich, Switzerland, 2020, vol. 164. ista: 'Henzinger MH, Neumann S, Wiese A. 2020. Dynamic approximate maximum independent set of intervals, hypercubes and hyperrectangles. 36th International Symposium on Computational Geometry. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 164, 51.' mla: Henzinger, Monika H., et al. “Dynamic Approximate Maximum Independent Set of Intervals, Hypercubes and Hyperrectangles.” 36th International Symposium on Computational Geometry, vol. 164, 51, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:10.4230/LIPIcs.SoCG.2020.51. short: M.H. Henzinger, S. Neumann, A. Wiese, in:, 36th International Symposium on Computational Geometry, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. conference: end_date: 2020-06-26 location: Zurich, Switzerland name: 'SoCG: Symposium on Computational Geometry' start_date: 2020-06-23 date_created: 2022-08-12T07:46:44Z date_published: 2020-06-08T00:00:00Z date_updated: 2023-02-14T10:00:58Z day: '08' doi: 10.4230/LIPIcs.SoCG.2020.51 extern: '1' external_id: arxiv: - '2003.02605' intvolume: ' 164' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.4230/LIPIcs.SoCG.2020.51 month: '06' oa: 1 oa_version: Published Version publication: 36th International Symposium on Computational Geometry publication_identifier: isbn: - '9783959771436' issn: - 1868-8969 publication_status: published publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik quality_controlled: '1' scopus_import: '1' status: public title: Dynamic approximate maximum independent set of intervals, hypercubes and hyperrectangles type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 164 year: '2020' ...