---
_id: '12602'
abstract:
- lang: eng
text: 'This study aims at developing and applying a spatially-distributed coupled
glacier mass balance and ice-flow model to attribute the response of glaciers
to natural and anthropogenic climate change. We focus on two glaciers with contrasting
surface characteristics: a debris-covered glacier (Langtang Glacier in Nepal)
and a clean-ice glacier (Hintereisferner in Austria). The model is applied from
the end of the Little Ice Age (1850) to the present-day (2016) and is forced with
four bias-corrected General Circulation Models (GCMs) from the historical experiment
of the CMIP5 archive. The selected GCMs represent region-specific warm-dry, warm-wet,
cold-dry, and cold-wet climate conditions. To isolate the effects of anthropogenic
climate change on glacier mass balance and flow runs from these GCMs with and
without further anthropogenic forcing after 1970 until 2016 are selected. The
outcomes indicate that both glaciers experience the largest reduction in area
and volume under warm climate conditions, whereas area and volume reductions are
smaller under cold climate conditions. Simultaneously with changes in glacier
area and volume, surface velocities generally decrease over time. Without further
anthropogenic forcing the results reveal a 3% (9%) smaller decline in glacier
area (volume) for the debris-covered glacier and a 18% (39%) smaller decline in
glacier area (volume) for the clean-ice glacier. The difference in the magnitude
between the two glaciers can mainly be attributed to differences in the response
time of the glaciers, where the clean-ice glacier shows a much faster response
to climate change. We conclude that the response of the two glaciers can mainly
be attributed to anthropogenic climate change and that the impact is larger on
the clean-ice glacier. The outcomes show that the model performs well under different
climate conditions and that the developed approach can be used for regional-scale
glacio-hydrological modeling.'
article_number: '143'
article_processing_charge: No
article_type: original
author:
- first_name: René R.
full_name: Wijngaard, René R.
last_name: Wijngaard
- first_name: Jakob F.
full_name: Steiner, Jakob F.
last_name: Steiner
- first_name: Philip D. A.
full_name: Kraaijenbrink, Philip D. A.
last_name: Kraaijenbrink
- first_name: Christoph
full_name: Klug, Christoph
last_name: Klug
- first_name: Surendra
full_name: Adhikari, Surendra
last_name: Adhikari
- first_name: Argha
full_name: Banerjee, Argha
last_name: Banerjee
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: Ludovicus P. H.
full_name: van Beek, Ludovicus P. H.
last_name: van Beek
- first_name: Marc F. P.
full_name: Bierkens, Marc F. P.
last_name: Bierkens
- first_name: Arthur F.
full_name: Lutz, Arthur F.
last_name: Lutz
- first_name: Walter W.
full_name: Immerzeel, Walter W.
last_name: Immerzeel
citation:
ama: Wijngaard RR, Steiner JF, Kraaijenbrink PDA, et al. Modeling the response of
the Langtang Glacier and the Hintereisferner to a changing climate since the Little
Ice Age. Frontiers in Earth Science. 2019;7. doi:10.3389/feart.2019.00143
apa: Wijngaard, R. R., Steiner, J. F., Kraaijenbrink, P. D. A., Klug, C., Adhikari,
S., Banerjee, A., … Immerzeel, W. W. (2019). Modeling the response of the Langtang
Glacier and the Hintereisferner to a changing climate since the Little Ice Age.
Frontiers in Earth Science. Frontiers Media. https://doi.org/10.3389/feart.2019.00143
chicago: Wijngaard, René R., Jakob F. Steiner, Philip D. A. Kraaijenbrink, Christoph
Klug, Surendra Adhikari, Argha Banerjee, Francesca Pellicciotti, et al. “Modeling
the Response of the Langtang Glacier and the Hintereisferner to a Changing Climate
since the Little Ice Age.” Frontiers in Earth Science. Frontiers Media,
2019. https://doi.org/10.3389/feart.2019.00143.
ieee: R. R. Wijngaard et al., “Modeling the response of the Langtang Glacier
and the Hintereisferner to a changing climate since the Little Ice Age,” Frontiers
in Earth Science, vol. 7. Frontiers Media, 2019.
ista: Wijngaard RR, Steiner JF, Kraaijenbrink PDA, Klug C, Adhikari S, Banerjee
A, Pellicciotti F, van Beek LPH, Bierkens MFP, Lutz AF, Immerzeel WW. 2019. Modeling
the response of the Langtang Glacier and the Hintereisferner to a changing climate
since the Little Ice Age. Frontiers in Earth Science. 7, 143.
mla: Wijngaard, René R., et al. “Modeling the Response of the Langtang Glacier and
the Hintereisferner to a Changing Climate since the Little Ice Age.” Frontiers
in Earth Science, vol. 7, 143, Frontiers Media, 2019, doi:10.3389/feart.2019.00143.
short: R.R. Wijngaard, J.F. Steiner, P.D.A. Kraaijenbrink, C. Klug, S. Adhikari,
A. Banerjee, F. Pellicciotti, L.P.H. van Beek, M.F.P. Bierkens, A.F. Lutz, W.W.
Immerzeel, Frontiers in Earth Science 7 (2019).
date_created: 2023-02-20T08:13:08Z
date_published: 2019-06-04T00:00:00Z
date_updated: 2023-02-28T12:04:48Z
day: '04'
doi: 10.3389/feart.2019.00143
extern: '1'
intvolume: ' 7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3389/feart.2019.00143
month: '06'
oa: 1
oa_version: Published Version
publication: Frontiers in Earth Science
publication_identifier:
issn:
- 2296-6463
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modeling the response of the Langtang Glacier and the Hintereisferner to a
changing climate since the Little Ice Age
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2019'
...
---
_id: '12601'
abstract:
- lang: eng
text: Ice cliffs and ponds on debris-covered glaciers have received increased attention
due to their role in amplifying local melt. However, very few studies have looked
at these features on the catchment scale to determine their patterns and changes
in space and time. We have compiled a detailed inventory of cliffs and ponds in
the Langtang catchment, central Himalaya, from six high-resolution satellite orthoimages
and DEMs between 2006 and 2015, and a historic orthophoto from 1974. Cliffs cover
between 1.4% (± 0.4%) in the dry and 3.4% (± 0.9%) in the wet seasons and ponds
between 0.6% (± 0.1%) and 1.6% (± 0.3%) of the total debris-covered tongues. We
find large variations between seasons, as cliffs and ponds tend to grow in the
wetter monsoon period, but there is no obvious trend in total area over the study
period. The inventory further shows that cliffs are predominately north-facing
irrespective of the glacier flow direction. Both cliffs and ponds appear in higher
densities several hundred metres from the terminus in areas where tributaries
reach the main glacier tongue. On the largest glacier in the catchment ~10% of
all cliffs and ponds persisted over nearly a decade.
article_processing_charge: No
article_type: original
author:
- first_name: JAKOB F.
full_name: STEINER, JAKOB F.
last_name: STEINER
- first_name: PASCAL
full_name: BURI, PASCAL
last_name: BURI
- first_name: EVAN S.
full_name: MILES, EVAN S.
last_name: MILES
- first_name: SILVAN
full_name: RAGETTLI, SILVAN
last_name: RAGETTLI
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
citation:
ama: 'STEINER JF, BURI P, MILES ES, RAGETTLI S, Pellicciotti F. Supraglacial ice
cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution and
characteristics. Journal of Glaciology. 2019;65(252):617-632. doi:10.1017/jog.2019.40'
apa: 'STEINER, J. F., BURI, P., MILES, E. S., RAGETTLI, S., & Pellicciotti,
F. (2019). Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal
distribution and characteristics. Journal of Glaciology. Cambridge University
Press. https://doi.org/10.1017/jog.2019.40'
chicago: 'STEINER, JAKOB F., PASCAL BURI, EVAN S. MILES, SILVAN RAGETTLI, and Francesca
Pellicciotti. “Supraglacial Ice Cliffs and Ponds on Debris-Covered Glaciers: Spatio-Temporal
Distribution and Characteristics.” Journal of Glaciology. Cambridge University
Press, 2019. https://doi.org/10.1017/jog.2019.40.'
ieee: 'J. F. STEINER, P. BURI, E. S. MILES, S. RAGETTLI, and F. Pellicciotti, “Supraglacial
ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution
and characteristics,” Journal of Glaciology, vol. 65, no. 252. Cambridge
University Press, pp. 617–632, 2019.'
ista: 'STEINER JF, BURI P, MILES ES, RAGETTLI S, Pellicciotti F. 2019. Supraglacial
ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution
and characteristics. Journal of Glaciology. 65(252), 617–632.'
mla: 'STEINER, JAKOB F., et al. “Supraglacial Ice Cliffs and Ponds on Debris-Covered
Glaciers: Spatio-Temporal Distribution and Characteristics.” Journal of Glaciology,
vol. 65, no. 252, Cambridge University Press, 2019, pp. 617–32, doi:10.1017/jog.2019.40.'
short: J.F. STEINER, P. BURI, E.S. MILES, S. RAGETTLI, F. Pellicciotti, Journal
of Glaciology 65 (2019) 617–632.
date_created: 2023-02-20T08:13:03Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2023-02-28T12:11:07Z
day: '01'
doi: 10.1017/jog.2019.40
extern: '1'
intvolume: ' 65'
issue: '252'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1017/jog.2019.40
month: '08'
oa: 1
oa_version: Published Version
page: 617-632
publication: Journal of Glaciology
publication_identifier:
eissn:
- 1727-5652
issn:
- 0022-1430
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal
distribution and characteristics'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 65
year: '2019'
...
---
_id: '12192'
abstract:
- lang: eng
text: Transposable elements (TEs), the movement of which can damage the genome,
are epigenetically silenced in eukaryotes. Intriguingly, TEs are activated in
the sperm companion cell – vegetative cell (VC) – of the flowering plant Arabidopsis
thaliana. However, the extent and mechanism of this activation are unknown. Here
we show that about 100 heterochromatic TEs are activated in VCs, mostly by DEMETER-catalyzed
DNA demethylation. We further demonstrate that DEMETER access to some of these
TEs is permitted by the natural depletion of linker histone H1 in VCs. Ectopically
expressed H1 suppresses TEs in VCs by reducing DNA demethylation and via a methylation-independent
mechanism. We demonstrate that H1 is required for heterochromatin condensation
in plant cells and show that H1 overexpression creates heterochromatic foci in
the VC progenitor cell. Taken together, our results demonstrate that the natural
depletion of H1 during male gametogenesis facilitates DEMETER-directed DNA demethylation,
heterochromatin relaxation, and TE activation.
acknowledgement: We thank David Twell for the pDONR-P4-P1R-pLAT52 and pDONR-P2R-P3-mRFP
vectors, the John Innes Centre Bioimaging Facility (Elaine Barclay and Grant Calder)
for their assistance with microscopy, and the Norwich BioScience Institute Partnership
Computing infrastructure for Science Group for High Performance Computing resources.
This work was funded by a Biotechnology and Biological Sciences Research Council
(BBSRC) David Phillips Fellowship (BB/L025043/1; SH, JZ and XF), a European Research
Council Starting Grant ('SexMeth' 804981; XF) and a Grant to Exceptional Researchers
by the Gatsby Charitable Foundation (SH and XF).
article_number: '42530'
article_processing_charge: No
article_type: original
author:
- first_name: Shengbo
full_name: He, Shengbo
last_name: He
- first_name: Martin
full_name: Vickers, Martin
last_name: Vickers
- first_name: Jingyi
full_name: Zhang, Jingyi
last_name: Zhang
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
citation:
ama: He S, Vickers M, Zhang J, Feng X. Natural depletion of histone H1 in sex cells
causes DNA demethylation, heterochromatin decondensation and transposon activation.
eLife. 2019;8. doi:10.7554/elife.42530
apa: He, S., Vickers, M., Zhang, J., & Feng, X. (2019). Natural depletion of
histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation
and transposon activation. ELife. eLife Sciences Publications, Ltd. https://doi.org/10.7554/elife.42530
chicago: He, Shengbo, Martin Vickers, Jingyi Zhang, and Xiaoqi Feng. “Natural Depletion
of Histone H1 in Sex Cells Causes DNA Demethylation, Heterochromatin Decondensation
and Transposon Activation.” ELife. eLife Sciences Publications, Ltd, 2019.
https://doi.org/10.7554/elife.42530.
ieee: S. He, M. Vickers, J. Zhang, and X. Feng, “Natural depletion of histone H1
in sex cells causes DNA demethylation, heterochromatin decondensation and transposon
activation,” eLife, vol. 8. eLife Sciences Publications, Ltd, 2019.
ista: He S, Vickers M, Zhang J, Feng X. 2019. Natural depletion of histone H1 in
sex cells causes DNA demethylation, heterochromatin decondensation and transposon
activation. eLife. 8, 42530.
mla: He, Shengbo, et al. “Natural Depletion of Histone H1 in Sex Cells Causes DNA
Demethylation, Heterochromatin Decondensation and Transposon Activation.” ELife,
vol. 8, 42530, eLife Sciences Publications, Ltd, 2019, doi:10.7554/elife.42530.
short: S. He, M. Vickers, J. Zhang, X. Feng, ELife 8 (2019).
date_created: 2023-01-16T09:17:21Z
date_published: 2019-05-28T00:00:00Z
date_updated: 2023-05-08T10:54:12Z
day: '28'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.7554/elife.42530
extern: '1'
external_id:
unknown:
- '31135340'
file:
- access_level: open_access
checksum: ea6b89c20d59e5eb3646916fe5d568ad
content_type: application/pdf
creator: alisjak
date_created: 2023-02-07T09:42:46Z
date_updated: 2023-02-07T09:42:46Z
file_id: '12525'
file_name: 2019_elife_He.pdf
file_size: 2493837
relation: main_file
success: 1
file_date_updated: 2023-02-07T09:42:46Z
has_accepted_license: '1'
intvolume: ' 8'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594752/
month: '05'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications, Ltd
quality_controlled: '1'
scopus_import: '1'
status: public
title: Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin
decondensation and transposon activation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2019'
...
---
_id: '8305'
abstract:
- lang: eng
text: In this paper, we present the first fully asynchronous distributed key generation
(ADKG) algorithm as well as the first distributed key generation algorithm that
can create keys with a dual (f,2f+1)−threshold that are necessary for scalable
consensus (which so far needs a trusted dealer assumption). In order to create
a DKG with a dual (f,2f+1)− threshold we first answer in the affirmative the open
question posed by Cachin et al. how to create an AVSS protocol with recovery thresholds
f+1Cryptology
ePrint Archive.'
apa: 'Kokoris Kogias, E., Spiegelman, A., Malkhi, D., & Abraham, I. (n.d.).
Bootstrapping consensus without trusted setup: fully asynchronous distributed
key generation. Cryptology ePrint Archive.'
chicago: 'Kokoris Kogias, Eleftherios, Alexander Spiegelman, Dahlia Malkhi, and
Ittai Abraham. “Bootstrapping Consensus without Trusted Setup: Fully Asynchronous
Distributed Key Generation.” Cryptology EPrint Archive, n.d.'
ieee: 'E. Kokoris Kogias, A. Spiegelman, D. Malkhi, and I. Abraham, “Bootstrapping
consensus without trusted setup: fully asynchronous distributed key generation,”
Cryptology ePrint Archive. .'
ista: 'Kokoris Kogias E, Spiegelman A, Malkhi D, Abraham I. Bootstrapping consensus
without trusted setup: fully asynchronous distributed key generation. Cryptology
ePrint Archive, 2019/1015.'
mla: 'Kokoris Kogias, Eleftherios, et al. “Bootstrapping Consensus without Trusted
Setup: Fully Asynchronous Distributed Key Generation.” Cryptology EPrint Archive,
2019/1015.'
short: E. Kokoris Kogias, A. Spiegelman, D. Malkhi, I. Abraham, Cryptology EPrint
Archive (n.d.).
date_created: 2020-08-26T12:18:00Z
date_published: 2019-09-10T00:00:00Z
date_updated: 2023-05-10T09:27:54Z
day: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2019/1015
month: '09'
oa: 1
oa_version: Preprint
publication: Cryptology ePrint Archive
publication_status: submitted
status: public
title: 'Bootstrapping consensus without trusted setup: fully asynchronous distributed
key generation'
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '12901'
article_processing_charge: No
author:
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: Janos
full_name: Kiss, Janos
id: 3D3A06F8-F248-11E8-B48F-1D18A9856A87
last_name: Kiss
- first_name: Stefano
full_name: Elefante, Stefano
id: 490F40CE-F248-11E8-B48F-1D18A9856A87
last_name: Elefante
citation:
ama: 'Schlögl A, Kiss J, Elefante S. Is Debian suitable for running an HPC Cluster?
In: AHPC19 - Austrian HPC Meeting 2019 . Institut für Mathematik und wissenschaftliches
Rechnen der Universität Graz; 2019:25.'
apa: 'Schlögl, A., Kiss, J., & Elefante, S. (2019). Is Debian suitable for running
an HPC Cluster? In AHPC19 - Austrian HPC Meeting 2019 (p. 25). Grundlsee,
Austria: Institut für Mathematik und wissenschaftliches Rechnen der Universität
Graz.'
chicago: Schlögl, Alois, Janos Kiss, and Stefano Elefante. “Is Debian Suitable for
Running an HPC Cluster?” In AHPC19 - Austrian HPC Meeting 2019 , 25. Institut
für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019.
ieee: A. Schlögl, J. Kiss, and S. Elefante, “Is Debian suitable for running an HPC
Cluster?,” in AHPC19 - Austrian HPC Meeting 2019 , Grundlsee, Austria,
2019, p. 25.
ista: 'Schlögl A, Kiss J, Elefante S. 2019. Is Debian suitable for running an HPC
Cluster? AHPC19 - Austrian HPC Meeting 2019 . AHPC: Austrian HPC Meeting, 25.'
mla: Schlögl, Alois, et al. “Is Debian Suitable for Running an HPC Cluster?” AHPC19
- Austrian HPC Meeting 2019 , Institut für Mathematik und wissenschaftliches
Rechnen der Universität Graz, 2019, p. 25.
short: A. Schlögl, J. Kiss, S. Elefante, in:, AHPC19 - Austrian HPC Meeting 2019
, Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz,
2019, p. 25.
conference:
end_date: 2019-02-27
location: Grundlsee, Austria
name: 'AHPC: Austrian HPC Meeting'
start_date: 2019-02-25
date_created: 2023-05-05T12:48:48Z
date_published: 2019-02-27T00:00:00Z
date_updated: 2023-05-16T07:29:32Z
day: '27'
ddc:
- '000'
department:
- _id: ScienComp
file:
- access_level: open_access
checksum: acc8272027faaf30709c51ac5c58ffa4
content_type: application/pdf
creator: dernst
date_created: 2023-05-16T07:27:09Z
date_updated: 2023-05-16T07:27:09Z
file_id: '12970'
file_name: 2019_AHPC_Schloegl.pdf
file_size: 1097603
relation: main_file
success: 1
file_date_updated: 2023-05-16T07:27:09Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ahpc19/BOOKLET_AHPC19.pdf
month: '02'
oa: 1
oa_version: Published Version
page: '25'
publication: 'AHPC19 - Austrian HPC Meeting 2019 '
publication_status: published
publisher: Institut für Mathematik und wissenschaftliches Rechnen der Universität
Graz
status: public
title: Is Debian suitable for running an HPC Cluster?
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11060'
abstract:
- lang: eng
text: The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum
(ER) that is gated by the nuclear pore complex. It is unknown whether proteins
of the INM and ER are degraded through shared or distinct pathways in mammalian
cells. We applied dynamic proteomics to profile protein half-lives and report
that INM and ER residents turn over at similar rates, indicating that the INM’s
unique topology is not a barrier to turnover. Using a microscopy approach, we
observed that the proteasome can degrade INM proteins in situ. However, we also
uncovered evidence for selective, vesicular transport-mediated turnover of a single
INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared
from the INM by a mechanism that requires emerin’s LEM domain to mediate vesicular
trafficking to lysosomes. This work demonstrates that the INM can be dynamically
remodeled in response to environmental inputs.
article_number: e49796
article_processing_charge: No
article_type: original
author:
- first_name: Abigail
full_name: Buchwalter, Abigail
last_name: Buchwalter
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Hsiao
full_name: Tsai, Hsiao
last_name: Tsai
- first_name: Juliana
full_name: Capitanio, Juliana
last_name: Capitanio
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Selective clearance
of the inner nuclear membrane protein emerin by vesicular transport during ER
stress. eLife. 2019;8. doi:10.7554/elife.49796
apa: Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., & Hetzer, M. (2019).
Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.49796
chicago: Buchwalter, Abigail, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, and
Martin Hetzer. “Selective Clearance of the Inner Nuclear Membrane Protein Emerin
by Vesicular Transport during ER Stress.” ELife. eLife Sciences Publications,
2019. https://doi.org/10.7554/elife.49796.
ieee: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, and M. Hetzer, “Selective
clearance of the inner nuclear membrane protein emerin by vesicular transport
during ER stress,” eLife, vol. 8. eLife Sciences Publications, 2019.
ista: Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. 2019. Selective clearance
of the inner nuclear membrane protein emerin by vesicular transport during ER
stress. eLife. 8, e49796.
mla: Buchwalter, Abigail, et al. “Selective Clearance of the Inner Nuclear Membrane
Protein Emerin by Vesicular Transport during ER Stress.” ELife, vol. 8,
e49796, eLife Sciences Publications, 2019, doi:10.7554/elife.49796.
short: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, M. Hetzer, ELife 8 (2019).
date_created: 2022-04-07T07:45:02Z
date_published: 2019-10-10T00:00:00Z
date_updated: 2023-05-31T06:36:22Z
day: '10'
ddc:
- '570'
doi: 10.7554/elife.49796
extern: '1'
external_id:
pmid:
- '31599721'
file:
- access_level: open_access
checksum: 1e8672a1e9c3dc0a2d3d0dad89673616
content_type: application/pdf
creator: dernst
date_created: 2022-04-08T08:18:01Z
date_updated: 2022-04-08T08:18:01Z
file_id: '11138'
file_name: 2019_eLife_Buchwalter.pdf
file_size: 6984654
relation: main_file
success: 1
file_date_updated: 2022-04-08T08:18:01Z
has_accepted_license: '1'
intvolume: ' 8'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '13079'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 8
year: '2019'
...
---
_id: '13079'
abstract:
- lang: eng
text: The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum
(ER) that is gated by the nuclear pore complex. It is unknown whether proteins
of the INM and ER are degraded through shared or distinct pathways in mammalian
cells. We applied dynamic proteomics to profile protein half-lives and report
that INM and ER residents turn over at similar rates, indicating that the INM’s
unique topology is not a barrier to turnover. Using a microscopy approach, we
observed that the proteasome can degrade INM proteins in situ. However, we also
uncovered evidence for selective, vesicular transport-mediated turnover of a single
INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared
from the INM by a mechanism that requires emerin’s LEM domain to mediate vesicular
trafficking to lysosomes. This work demonstrates that the INM can be dynamically
remodeled in response to environmental inputs.
article_processing_charge: No
author:
- first_name: Abigail
full_name: Buchwalter, Abigail
last_name: Buchwalter
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Hsiao
full_name: Tsai, Hsiao
last_name: Tsai
- first_name: Juliana
full_name: Capitanio, Juliana
last_name: Capitanio
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: 'Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Data from: Selective
clearance of the inner nuclear membrane protein emerin by vesicular transport
during ER stress. 2019. doi:10.5061/DRYAD.N0R525H'
apa: 'Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., & Hetzer, M. (2019).
Data from: Selective clearance of the inner nuclear membrane protein emerin by
vesicular transport during ER stress. Dryad. https://doi.org/10.5061/DRYAD.N0R525H'
chicago: 'Buchwalter, Abigail, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, and
Martin Hetzer. “Data from: Selective Clearance of the Inner Nuclear Membrane Protein
Emerin by Vesicular Transport during ER Stress.” Dryad, 2019. https://doi.org/10.5061/DRYAD.N0R525H.'
ieee: 'A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, and M. Hetzer, “Data from:
Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress.” Dryad, 2019.'
ista: 'Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. 2019. Data from:
Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress, Dryad, 10.5061/DRYAD.N0R525H.'
mla: 'Buchwalter, Abigail, et al. Data from: Selective Clearance of the Inner
Nuclear Membrane Protein Emerin by Vesicular Transport during ER Stress. Dryad,
2019, doi:10.5061/DRYAD.N0R525H.'
short: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, M. Hetzer, (2019).
date_created: 2023-05-23T17:09:30Z
date_published: 2019-10-28T00:00:00Z
date_updated: 2023-05-31T06:36:23Z
day: '28'
ddc:
- '570'
doi: 10.5061/DRYAD.N0R525H
extern: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.n0r525h
month: '10'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '11060'
relation: used_in_publication
status: public
status: public
title: 'Data from: Selective clearance of the inner nuclear membrane protein emerin
by vesicular transport during ER stress'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '6989'
abstract:
- lang: eng
text: 'When can a polyomino piece of paper be folded into a unit cube? Prior work
studied tree-like polyominoes, but polyominoes with holes remain an intriguing
open problem. We present sufficient conditions for a polyomino with hole(s) to
fold into a cube, and conditions under which cube folding is impossible. In particular,
we show that all but five special simple holes guarantee foldability. '
acknowledgement: This research was performed in part at the 33rd BellairsWinter Workshop on Computational Geometry. Wethank
all other participants for a fruitful atmosphere.
article_processing_charge: No
author:
- first_name: Oswin
full_name: Aichholzer, Oswin
last_name: Aichholzer
- first_name: Hugo A
full_name: Akitaya, Hugo A
last_name: Akitaya
- first_name: Kenneth C
full_name: Cheung, Kenneth C
last_name: Cheung
- first_name: Erik D
full_name: Demaine, Erik D
last_name: Demaine
- first_name: Martin L
full_name: Demaine, Martin L
last_name: Demaine
- first_name: Sandor P
full_name: Fekete, Sandor P
last_name: Fekete
- first_name: Linda
full_name: Kleist, Linda
last_name: Kleist
- first_name: Irina
full_name: Kostitsyna, Irina
last_name: Kostitsyna
- first_name: Maarten
full_name: Löffler, Maarten
last_name: Löffler
- first_name: Zuzana
full_name: Masárová, Zuzana
id: 45CFE238-F248-11E8-B48F-1D18A9856A87
last_name: Masárová
orcid: 0000-0002-6660-1322
- first_name: Klara
full_name: Mundilova, Klara
last_name: Mundilova
- first_name: Christiane
full_name: Schmidt, Christiane
last_name: Schmidt
citation:
ama: 'Aichholzer O, Akitaya HA, Cheung KC, et al. Folding polyominoes with holes
into a cube. In: Proceedings of the 31st Canadian Conference on Computational
Geometry. Canadian Conference on Computational Geometry; 2019:164-170.'
apa: 'Aichholzer, O., Akitaya, H. A., Cheung, K. C., Demaine, E. D., Demaine, M.
L., Fekete, S. P., … Schmidt, C. (2019). Folding polyominoes with holes into a
cube. In Proceedings of the 31st Canadian Conference on Computational Geometry
(pp. 164–170). Edmonton, Canada: Canadian Conference on Computational Geometry.'
chicago: Aichholzer, Oswin, Hugo A Akitaya, Kenneth C Cheung, Erik D Demaine, Martin
L Demaine, Sandor P Fekete, Linda Kleist, et al. “Folding Polyominoes with Holes
into a Cube.” In Proceedings of the 31st Canadian Conference on Computational
Geometry, 164–70. Canadian Conference on Computational Geometry, 2019.
ieee: O. Aichholzer et al., “Folding polyominoes with holes into a cube,”
in Proceedings of the 31st Canadian Conference on Computational Geometry,
Edmonton, Canada, 2019, pp. 164–170.
ista: 'Aichholzer O, Akitaya HA, Cheung KC, Demaine ED, Demaine ML, Fekete SP, Kleist
L, Kostitsyna I, Löffler M, Masárová Z, Mundilova K, Schmidt C. 2019. Folding
polyominoes with holes into a cube. Proceedings of the 31st Canadian Conference
on Computational Geometry. CCCG: Canadian Conference in Computational Geometry,
164–170.'
mla: Aichholzer, Oswin, et al. “Folding Polyominoes with Holes into a Cube.” Proceedings
of the 31st Canadian Conference on Computational Geometry, Canadian Conference
on Computational Geometry, 2019, pp. 164–70.
short: O. Aichholzer, H.A. Akitaya, K.C. Cheung, E.D. Demaine, M.L. Demaine, S.P.
Fekete, L. Kleist, I. Kostitsyna, M. Löffler, Z. Masárová, K. Mundilova, C. Schmidt,
in:, Proceedings of the 31st Canadian Conference on Computational Geometry, Canadian
Conference on Computational Geometry, 2019, pp. 164–170.
conference:
end_date: 2019-08-10
location: Edmonton, Canada
name: 'CCCG: Canadian Conference in Computational Geometry'
start_date: 2019-08-08
date_created: 2019-11-04T16:46:11Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2023-08-04T10:57:42Z
day: '01'
department:
- _id: HeEd
external_id:
arxiv:
- '1910.09917'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://cccg.ca/proceedings/2019/proceedings.pdf
month: '08'
oa: 1
oa_version: Published Version
page: 164-170
publication: Proceedings of the 31st Canadian Conference on Computational Geometry
publication_status: published
publisher: Canadian Conference on Computational Geometry
quality_controlled: '1'
related_material:
record:
- id: '8317'
relation: extended_version
status: public
scopus_import: '1'
status: public
title: Folding polyominoes with holes into a cube
type: conference
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
year: '2019'
...
---
_id: '13372'
abstract:
- lang: eng
text: 'The capacity to respond or adapt to environmental changes is an intrinsic
property of living systems that comprise highly-connected subcomponents communicating
through chemical networks. The development of responsive synthetic systems is
a relatively new research area that covers different disciplines, among which
nanochemistry brings conceptually new demonstrations. Especially attractive are
ligand-protected gold nanoparticles, which have been extensively used over the
last decade as building blocks in constructing superlattices or dynamic aggregates,
under the effect of an applied stimulus. To reflect the importance of surface
chemistry and nanoparticle core composition in the dynamic self-assembly of nanoparticles,
we provide here an overview of various available stimuli, as tools for synthetic
chemists to exploit. Along with this task, the review starts with the use of chemical
stimuli such as solvent, pH, gases, metal ions or biomolecules. It then focuses
on physical stimuli: temperature, magnetic and electric fields, as well as light.
To reflect on the increasing complexity of current architectures, we discuss systems
that are responsive to more than one stimulus, to finally encourage further research
by proposing future challenges.'
article_processing_charge: No
article_type: original
author:
- first_name: Marek
full_name: Grzelczak, Marek
last_name: Grzelczak
- first_name: Luis M.
full_name: Liz-Marzán, Luis M.
last_name: Liz-Marzán
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
citation:
ama: Grzelczak M, Liz-Marzán LM, Klajn R. Stimuli-responsive self-assembly of nanoparticles.
Chemical Society Reviews. 2019;48(5):1342-1361. doi:10.1039/c8cs00787j
apa: Grzelczak, M., Liz-Marzán, L. M., & Klajn, R. (2019). Stimuli-responsive
self-assembly of nanoparticles. Chemical Society Reviews. Royal Society
of Chemistry. https://doi.org/10.1039/c8cs00787j
chicago: Grzelczak, Marek, Luis M. Liz-Marzán, and Rafal Klajn. “Stimuli-Responsive
Self-Assembly of Nanoparticles.” Chemical Society Reviews. Royal Society
of Chemistry, 2019. https://doi.org/10.1039/c8cs00787j.
ieee: M. Grzelczak, L. M. Liz-Marzán, and R. Klajn, “Stimuli-responsive self-assembly
of nanoparticles,” Chemical Society Reviews, vol. 48, no. 5. Royal Society
of Chemistry, pp. 1342–1361, 2019.
ista: Grzelczak M, Liz-Marzán LM, Klajn R. 2019. Stimuli-responsive self-assembly
of nanoparticles. Chemical Society Reviews. 48(5), 1342–1361.
mla: Grzelczak, Marek, et al. “Stimuli-Responsive Self-Assembly of Nanoparticles.”
Chemical Society Reviews, vol. 48, no. 5, Royal Society of Chemistry, 2019,
pp. 1342–61, doi:10.1039/c8cs00787j.
short: M. Grzelczak, L.M. Liz-Marzán, R. Klajn, Chemical Society Reviews 48 (2019)
1342–1361.
date_created: 2023-08-01T09:38:52Z
date_published: 2019-01-28T00:00:00Z
date_updated: 2023-08-07T10:48:31Z
day: '28'
doi: 10.1039/c8cs00787j
extern: '1'
external_id:
pmid:
- '30688963'
intvolume: ' 48'
issue: '5'
keyword:
- General Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1039/C8CS00787J
month: '01'
oa: 1
oa_version: Published Version
page: 1342-1361
pmid: 1
publication: Chemical Society Reviews
publication_identifier:
eissn:
- 1460-4744
issn:
- 0306-0012
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stimuli-responsive self-assembly of nanoparticles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2019'
...
---
_id: '13369'
abstract:
- lang: eng
text: Arylazopyrazoles represent a new family of molecular photoswitches characterized
by a near-quantitative conversion between two states and long thermal half-lives
of the metastable state. Here, we investigated the behavior of a model arylazopyrazole
in the presence of a self-assembled cage based on Pd–imidazole coordination. Owing
to its high water solubility, the cage can solubilize the E isomer of arylazopyrazole,
which, by itself, is not soluble in water. NMR spectroscopy and X-ray crystallography
have independently demonstrated that each cage can encapsulate two molecules of
E-arylazopyrazole. UV-induced switching to the Z isomer was accompanied by the
release of one of the two guests from the cage and the formation of a 1:1 cage/Z-arylazopyrazole
inclusion complex. DFT calculations suggest that this process involves a dramatic
change in the conformation of the cage. Back-isomerization was induced with green
light and resulted in the initial 1:2 cage/E-arylazopyrazole complex. This back-isomerization
reaction also proceeded in the dark, with a rate significantly higher than in
the absence of the cage.
article_processing_charge: No
article_type: original
author:
- first_name: Anton I
full_name: Hanopolskyi, Anton I
last_name: Hanopolskyi
- first_name: Soumen
full_name: De, Soumen
last_name: De
- first_name: Michał J
full_name: Białek, Michał J
last_name: Białek
- first_name: Yael
full_name: Diskin-Posner, Yael
last_name: Diskin-Posner
- first_name: Liat
full_name: Avram, Liat
last_name: Avram
- first_name: Moran
full_name: Feller, Moran
last_name: Feller
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
citation:
ama: Hanopolskyi AI, De S, Białek MJ, et al. Reversible switching of arylazopyrazole
within a metal–organic cage. Beilstein Journal of Organic Chemistry. 2019;15:2398-2407.
doi:10.3762/bjoc.15.232
apa: Hanopolskyi, A. I., De, S., Białek, M. J., Diskin-Posner, Y., Avram, L., Feller,
M., & Klajn, R. (2019). Reversible switching of arylazopyrazole within a metal–organic
cage. Beilstein Journal of Organic Chemistry. Beilstein Institut. https://doi.org/10.3762/bjoc.15.232
chicago: Hanopolskyi, Anton I, Soumen De, Michał J Białek, Yael Diskin-Posner, Liat
Avram, Moran Feller, and Rafal Klajn. “Reversible Switching of Arylazopyrazole
within a Metal–Organic Cage.” Beilstein Journal of Organic Chemistry. Beilstein
Institut, 2019. https://doi.org/10.3762/bjoc.15.232.
ieee: A. I. Hanopolskyi et al., “Reversible switching of arylazopyrazole
within a metal–organic cage,” Beilstein Journal of Organic Chemistry, vol.
15. Beilstein Institut, pp. 2398–2407, 2019.
ista: Hanopolskyi AI, De S, Białek MJ, Diskin-Posner Y, Avram L, Feller M, Klajn
R. 2019. Reversible switching of arylazopyrazole within a metal–organic cage.
Beilstein Journal of Organic Chemistry. 15, 2398–2407.
mla: Hanopolskyi, Anton I., et al. “Reversible Switching of Arylazopyrazole within
a Metal–Organic Cage.” Beilstein Journal of Organic Chemistry, vol. 15,
Beilstein Institut, 2019, pp. 2398–407, doi:10.3762/bjoc.15.232.
short: A.I. Hanopolskyi, S. De, M.J. Białek, Y. Diskin-Posner, L. Avram, M. Feller,
R. Klajn, Beilstein Journal of Organic Chemistry 15 (2019) 2398–2407.
date_created: 2023-08-01T09:38:06Z
date_published: 2019-10-10T00:00:00Z
date_updated: 2023-08-07T10:34:56Z
day: '10'
doi: 10.3762/bjoc.15.232
extern: '1'
external_id:
pmid:
- '31666874'
intvolume: ' 15'
keyword:
- Organic Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3762/bjoc.15.232
month: '10'
oa: 1
oa_version: Published Version
page: 2398-2407
pmid: 1
publication: Beilstein Journal of Organic Chemistry
publication_identifier:
eissn:
- 1860-5397
publication_status: published
publisher: Beilstein Institut
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reversible switching of arylazopyrazole within a metal–organic cage
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2019'
...