@article{5911, abstract = {Empirical data suggest that inversions in many species contain genes important for intraspecific divergence and speciation, yet mechanisms of evolution remain unclear. While genes inside an inversion are tightly linked, inversions are not static but evolve separately from the rest of the genome by new mutations, recombination within arrangements, and gene flux between arrangements. Inversion polymorphisms are maintained by different processes, for example, divergent or balancing selection, or a mix of multiple processes. Moreover, the relative roles of selection, drift, mutation, and recombination will change over the lifetime of an inversion and within its area of distribution. We believe inversions are central to the evolution of many species, but we need many more data and new models to understand the complex mechanisms involved.}, author = {Faria, Rui and Johannesson, Kerstin and Butlin, Roger K. and Westram, Anja M}, issn = {01695347}, journal = {Trends in Ecology and Evolution}, number = {3}, pages = {239--248}, publisher = {Elsevier}, title = {{Evolving inversions}}, doi = {10.1016/j.tree.2018.12.005}, volume = {34}, year = {2019}, } @article{439, abstract = {We count points over a finite field on wild character varieties,of Riemann surfaces for singularities with regular semisimple leading term. The new feature in our counting formulas is the appearance of characters of Yokonuma–Hecke algebras. Our result leads to the conjecture that the mixed Hodge polynomials of these character varieties agree with previously conjectured perverse Hodge polynomials of certain twisted parabolic Higgs moduli spaces, indicating the possibility of a P = W conjecture for a suitable wild Hitchin system.}, author = {Hausel, Tamas and Mereb, Martin and Wong, Michael}, issn = {1435-9855}, journal = {Journal of the European Mathematical Society}, number = {10}, pages = {2995--3052}, publisher = {European Mathematical Society}, title = {{Arithmetic and representation theory of wild character varieties}}, doi = {10.4171/JEMS/896}, volume = {21}, year = {2019}, } @article{105, abstract = {Clinical Utility Gene Card. 1. Name of Disease (Synonyms): Pontocerebellar hypoplasia type 9 (PCH9) and spastic paraplegia-63 (SPG63). 2. OMIM# of the Disease: 615809 and 615686. 3. Name of the Analysed Genes or DNA/Chromosome Segments: AMPD2 at 1p13.3. 4. OMIM# of the Gene(s): 102771.}, author = {Marsh, Ashley and Novarino, Gaia and Lockhart, Paul and Leventer, Richard}, journal = {European Journal of Human Genetics}, pages = {161--166}, publisher = {Springer Nature}, title = {{CUGC for pontocerebellar hypoplasia type 9 and spastic paraplegia-63}}, doi = {10.1038/s41431-018-0231-2}, volume = {27}, year = {2019}, } @article{65, abstract = {We provide an entropy formulation for porous medium-type equations with a stochastic, non-linear, spatially inhomogeneous forcing. Well-posedness and L1-contraction is obtained in the class of entropy solutions. Our scope allows for porous medium operators Δ(|u|m−1u) for all m∈(1,∞), and Hölder continuous diffusion nonlinearity with exponent 1/2.}, author = {Dareiotis, Konstantinos and Gerencser, Mate and Gess, Benjamin}, journal = {Journal of Differential Equations}, number = {6}, pages = {3732--3763}, publisher = {Elsevier}, title = {{Entropy solutions for stochastic porous media equations}}, doi = {10.1016/j.jde.2018.09.012}, volume = {266}, year = {2019}, } @article{5907, abstract = {Microalgae of the genus Chlorella vulgaris are candidates for the production of lipids for biofuel production. Besides that, Chlorella vulgaris is marketed as protein and vitamin rich food additive. Its potential as a novel expression system for recombinant proteins inspired us to study its asparagine-linked oligosaccharides (N-glycans) by mass spectrometry, chromatography and gas chromatography. Oligomannosidic N-glycans with up to nine mannoses were the structures found in culture collection strains as well as several commercial products. These glycans co-eluted with plant N-glycans in the highly shape selective porous graphitic carbon chromatography. Thus, Chlorella vulgaris generates oligomannosidic N-glycans of the structural type known from land plants and animals. In fact, Man5 (Man5GlcNAc2) served as substrate for GlcNAc-transferase I and a trace of an endogenous structure with terminal GlcNAc was seen. The unusual more linear Man5 structure recently found on glycoproteins of Chlamydomonas reinhardtii occurred - if at all - in traces only. Notably, a majority of the oligomannosidic glycans was multiply O-methylated with 3-O-methyl and 3,6-di-O-methyl mannoses at the non-reducing termini. This modification has so far been neither found on plant nor vertebrate N-glycans. It’s possible immunogenicity raises concerns as to the use of C. vulgaris for production of pharmaceutical glycoproteins.}, author = {Mócsai, Réka and Figl, Rudolf and Troschl, Clemens and Strasser, Richard and Svehla, Elisabeth and Windwarder, Markus and Thader, Andreas and Altmann, Friedrich}, journal = {Scientific Reports}, number = {1}, publisher = {Nature Publishing Group}, title = {{N-glycans of the microalga Chlorella vulgaris are of the oligomannosidic type but highly methylated}}, doi = {10.1038/s41598-018-36884-1}, volume = {9}, year = {2019}, }