---
_id: '273'
abstract:
- lang: eng
text: The accuracy of information retrieval systems is often measured using complex
loss functions such as the average precision (AP) or the normalized discounted
cumulative gain (NDCG). Given a set of positive and negative samples, the parameters
of a retrieval system can be estimated by minimizing these loss functions. However,
the non-differentiability and non-decomposability of these loss functions does
not allow for simple gradient based optimization algorithms. This issue is generally
circumvented by either optimizing a structured hinge-loss upper bound to the loss
function or by using asymptotic methods like the direct-loss minimization framework.
Yet, the high computational complexity of loss-augmented inference, which is necessary
for both the frameworks, prohibits its use in large training data sets. To alleviate
this deficiency, we present a novel quicksort flavored algorithm for a large class
of non-decomposable loss functions. We provide a complete characterization of
the loss functions that are amenable to our algorithm, and show that it includes
both AP and NDCG based loss functions. Furthermore, we prove that no comparison
based algorithm can improve upon the computational complexity of our approach
asymptotically. We demonstrate the effectiveness of our approach in the context
of optimizing the structured hinge loss upper bound of AP and NDCG loss for learning
models for a variety of vision tasks. We show that our approach provides significantly
better results than simpler decomposable loss functions, while requiring a comparable
training time.
article_processing_charge: No
author:
- first_name: Pritish
full_name: Mohapatra, Pritish
last_name: Mohapatra
- first_name: Michal
full_name: Rolinek, Michal
id: 3CB3BC06-F248-11E8-B48F-1D18A9856A87
last_name: Rolinek
- first_name: C V
full_name: Jawahar, C V
last_name: Jawahar
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
- first_name: M Pawan
full_name: Kumar, M Pawan
last_name: Kumar
citation:
ama: 'Mohapatra P, Rolinek M, Jawahar CV, Kolmogorov V, Kumar MP. Efficient optimization
for rank-based loss functions. In: 2018 IEEE/CVF Conference on Computer Vision
and Pattern Recognition. IEEE; 2018:3693-3701. doi:10.1109/cvpr.2018.00389'
apa: 'Mohapatra, P., Rolinek, M., Jawahar, C. V., Kolmogorov, V., & Kumar, M.
P. (2018). Efficient optimization for rank-based loss functions. In 2018 IEEE/CVF
Conference on Computer Vision and Pattern Recognition (pp. 3693–3701). Salt
Lake City, UT, USA: IEEE. https://doi.org/10.1109/cvpr.2018.00389'
chicago: Mohapatra, Pritish, Michal Rolinek, C V Jawahar, Vladimir Kolmogorov, and
M Pawan Kumar. “Efficient Optimization for Rank-Based Loss Functions.” In 2018
IEEE/CVF Conference on Computer Vision and Pattern Recognition, 3693–3701.
IEEE, 2018. https://doi.org/10.1109/cvpr.2018.00389.
ieee: P. Mohapatra, M. Rolinek, C. V. Jawahar, V. Kolmogorov, and M. P. Kumar, “Efficient
optimization for rank-based loss functions,” in 2018 IEEE/CVF Conference on
Computer Vision and Pattern Recognition, Salt Lake City, UT, USA, 2018, pp.
3693–3701.
ista: 'Mohapatra P, Rolinek M, Jawahar CV, Kolmogorov V, Kumar MP. 2018. Efficient
optimization for rank-based loss functions. 2018 IEEE/CVF Conference on Computer
Vision and Pattern Recognition. CVPR: Conference on Computer Vision and Pattern
Recognition, 3693–3701.'
mla: Mohapatra, Pritish, et al. “Efficient Optimization for Rank-Based Loss Functions.”
2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, IEEE,
2018, pp. 3693–701, doi:10.1109/cvpr.2018.00389.
short: P. Mohapatra, M. Rolinek, C.V. Jawahar, V. Kolmogorov, M.P. Kumar, in:, 2018
IEEE/CVF Conference on Computer Vision and Pattern Recognition, IEEE, 2018, pp.
3693–3701.
conference:
end_date: 2018-06-22
location: Salt Lake City, UT, USA
name: 'CVPR: Conference on Computer Vision and Pattern Recognition'
start_date: 2018-06-18
date_created: 2018-12-11T11:45:33Z
date_published: 2018-06-28T00:00:00Z
date_updated: 2023-09-11T13:24:43Z
day: '28'
department:
- _id: VlKo
doi: 10.1109/cvpr.2018.00389
ec_funded: 1
external_id:
arxiv:
- '1604.08269'
isi:
- '000457843603087'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1604.08269
month: '06'
oa: 1
oa_version: Preprint
page: 3693-3701
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '616160'
name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication: 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition
publication_identifier:
isbn:
- '9781538664209'
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient optimization for rank-based loss functions
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '289'
abstract:
- lang: eng
text: We report on quantum capacitance measurements of high quality, graphite- and
hexagonal boron nitride encapsulated Bernal stacked trilayer graphene devices.
At zero applied magnetic field, we observe a number of electron density- and electrical
displacement-tuned features in the electronic compressibility associated with
changes in Fermi surface topology. At high displacement field and low density,
strong trigonal warping gives rise to emergent Dirac gullies centered near the
corners of the hexagonal Brillouin and related by three fold rotation symmetry.
At low magnetic fields of B=1.25~T, the gullies manifest as a change in the degeneracy
of the Landau levels from two to three. Weak incompressible states are also observed
at integer filling within these triplets Landau levels, which a Hartree-Fock analysis
indicates are associated with Coulomb-driven nematic phases that spontaneously
break rotation symmetry.
acknowledgement: The experimental work at UCSB was funded by the National Science
Foundation under Grant No. DMR- 1654186. Work at Columbia was supported by the National
Science Foundation under Grant No. DMR- 1507788. K. W. and T. T. acknowledge support
from the Elemental Strategy Initiative conducted by the Ministry of Education, Culture,
Sports, Science and Technology, Japan, and the Japan Society for the Promotion of
Science KAKENHI Grant No. JP15K21722. E. M. S. acknowledges the support of the Elings
Fellowship from the California Nanosystems Institute at the University of California,
Santa Barbara. A. F. Y. acknowledges the support of the David and Lucile Packard
foundation and the Sloan Foundation. Measurements made use of a dilution refrigerator
funded through the Major Research Instrumentation program of the U.S. National Science
Foundation under Grant No. DMR- 1531389, and the MRL Shared Experimental Facilities,
which are supported by the MRSEC Program of the U.S. National Science Foundation
under Grant No. DMR- 1720256.
article_number: '167601'
article_processing_charge: No
article_type: original
author:
- first_name: Alexander
full_name: Zibrov, Alexander
last_name: Zibrov
- first_name: Rao
full_name: Peng, Rao
id: 47C23AC6-02D0-11E9-BD0E-99399A5D3DEB
last_name: Peng
orcid: 0000-0003-1250-0021
- first_name: Carlos
full_name: Kometter, Carlos
last_name: Kometter
- first_name: Jia
full_name: Li, Jia
last_name: Li
- first_name: Cory
full_name: Dean, Cory
last_name: Dean
- first_name: Takashi
full_name: Taniguchi, Takashi
last_name: Taniguchi
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: Zibrov A, Rao P, Kometter C, et al. Emergent dirac gullies and gully-symmetry-breaking
quantum hall states in ABA trilayer graphene. Physical Review Letters.
2018;121(16). doi:10.1103/PhysRevLett.121.167601
apa: Zibrov, A., Rao, P., Kometter, C., Li, J., Dean, C., Taniguchi, T., … Young,
A. (2018). Emergent dirac gullies and gully-symmetry-breaking quantum hall states
in ABA trilayer graphene. Physical Review Letters. American Physical Society.
https://doi.org/10.1103/PhysRevLett.121.167601
chicago: Zibrov, Alexander, Peng Rao, Carlos Kometter, Jia Li, Cory Dean, Takashi
Taniguchi, Kenji Watanabe, Maksym Serbyn, and Andrea Young. “Emergent Dirac Gullies
and Gully-Symmetry-Breaking Quantum Hall States in ABA Trilayer Graphene.” Physical
Review Letters. American Physical Society, 2018. https://doi.org/10.1103/PhysRevLett.121.167601.
ieee: A. Zibrov et al., “Emergent dirac gullies and gully-symmetry-breaking
quantum hall states in ABA trilayer graphene,” Physical Review Letters,
vol. 121, no. 16. American Physical Society, 2018.
ista: Zibrov A, Rao P, Kometter C, Li J, Dean C, Taniguchi T, Watanabe K, Serbyn
M, Young A. 2018. Emergent dirac gullies and gully-symmetry-breaking quantum hall
states in ABA trilayer graphene. Physical Review Letters. 121(16), 167601.
mla: Zibrov, Alexander, et al. “Emergent Dirac Gullies and Gully-Symmetry-Breaking
Quantum Hall States in ABA Trilayer Graphene.” Physical Review Letters,
vol. 121, no. 16, 167601, American Physical Society, 2018, doi:10.1103/PhysRevLett.121.167601.
short: A. Zibrov, P. Rao, C. Kometter, J. Li, C. Dean, T. Taniguchi, K. Watanabe,
M. Serbyn, A. Young, Physical Review Letters 121 (2018).
date_created: 2018-12-11T11:45:38Z
date_published: 2018-10-19T00:00:00Z
date_updated: 2023-09-11T13:39:50Z
day: '19'
department:
- _id: MaSe
doi: 10.1103/PhysRevLett.121.167601
external_id:
arxiv:
- '1805.01038'
isi:
- '000447307500007'
intvolume: ' 121'
isi: 1
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1805.01038
month: '10'
oa: 1
oa_version: Preprint
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Emergent dirac gullies and gully-symmetry-breaking quantum hall states in ABA
trilayer graphene
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 121
year: '2018'
...
---
_id: '287'
abstract:
- lang: eng
text: In this paper, we discuss biological effects of electromagnetic (EM) fields
in the context of cancer biology. In particular, we review the nanomechanical
properties of microtubules (MTs), the latter being one of the most successful
targets for cancer therapy. We propose an investigation on the coupling of electromagnetic
radiation to mechanical vibrations of MTs as an important basis for biological
and medical applications. In our opinion, optomechanical methods can accurately
monitor and control the mechanical properties of isolated MTs in a liquid environment.
Consequently, studying nanomechanical properties of MTs may give useful information
for future applications to diagnostic and therapeutic technologies involving non-invasive
externally applied physical fields. For example, electromagnetic fields or high
intensity ultrasound can be used therapeutically avoiding harmful side effects
of chemotherapeutic agents or classical radiation therapy.
acknowledgement: The work of SB has been supported by the European Unions Horizon
2020 research and innovation program under the Marie Sklodowska Curie grant agreement
No MSC-IF 707438 SUPEREOM. JAT gratefully acknowledges funding support from NSERC
(Canada) for his research. MC acknowledges support from the Czech Science Foundation,
projects 15-17102S and 17-11898S and he participates in COST Action BM1309, CA15211
and bilateral exchange project between Czech and Slovak Academies of Sciences, SAV-15-22.
article_processing_charge: No
author:
- first_name: Vahid
full_name: Salari, Vahid
last_name: Salari
- first_name: Shabir
full_name: Barzanjeh, Shabir
id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
last_name: Barzanjeh
orcid: 0000-0003-0415-1423
- first_name: Michal
full_name: Cifra, Michal
last_name: Cifra
- first_name: Christoph
full_name: Simon, Christoph
last_name: Simon
- first_name: Felix
full_name: Scholkmann, Felix
last_name: Scholkmann
- first_name: Zahra
full_name: Alirezaei, Zahra
last_name: Alirezaei
- first_name: Jack
full_name: Tuszynski, Jack
last_name: Tuszynski
citation:
ama: Salari V, Barzanjeh S, Cifra M, et al. Electromagnetic fields and optomechanics
In cancer diagnostics and treatment. Frontiers in Bioscience - Landmark.
2018;23(8):1391-1406. doi:10.2741/4651
apa: Salari, V., Barzanjeh, S., Cifra, M., Simon, C., Scholkmann, F., Alirezaei,
Z., & Tuszynski, J. (2018). Electromagnetic fields and optomechanics In cancer
diagnostics and treatment. Frontiers in Bioscience - Landmark. Frontiers
in Bioscience. https://doi.org/10.2741/4651
chicago: Salari, Vahid, Shabir Barzanjeh, Michal Cifra, Christoph Simon, Felix Scholkmann,
Zahra Alirezaei, and Jack Tuszynski. “Electromagnetic Fields and Optomechanics
In Cancer Diagnostics and Treatment.” Frontiers in Bioscience - Landmark.
Frontiers in Bioscience, 2018. https://doi.org/10.2741/4651.
ieee: V. Salari et al., “Electromagnetic fields and optomechanics In cancer
diagnostics and treatment,” Frontiers in Bioscience - Landmark, vol. 23,
no. 8. Frontiers in Bioscience, pp. 1391–1406, 2018.
ista: Salari V, Barzanjeh S, Cifra M, Simon C, Scholkmann F, Alirezaei Z, Tuszynski
J. 2018. Electromagnetic fields and optomechanics In cancer diagnostics and treatment.
Frontiers in Bioscience - Landmark. 23(8), 1391–1406.
mla: Salari, Vahid, et al. “Electromagnetic Fields and Optomechanics In Cancer Diagnostics
and Treatment.” Frontiers in Bioscience - Landmark, vol. 23, no. 8, Frontiers
in Bioscience, 2018, pp. 1391–406, doi:10.2741/4651.
short: V. Salari, S. Barzanjeh, M. Cifra, C. Simon, F. Scholkmann, Z. Alirezaei,
J. Tuszynski, Frontiers in Bioscience - Landmark 23 (2018) 1391–1406.
date_created: 2018-12-11T11:45:37Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2023-09-11T13:38:14Z
day: '01'
department:
- _id: JoFi
doi: 10.2741/4651
ec_funded: 1
external_id:
isi:
- '000439042800001'
pmid:
- '29293441'
intvolume: ' 23'
isi: 1
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.bioscience.org/2018/v23/af/4651/fulltext.htm
month: '03'
oa: 1
oa_version: Submitted Version
page: 1391 - 1406
pmid: 1
project:
- _id: 258047B6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '707438'
name: 'Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination
with cavity Optomechanics SUPEREOM'
publication: Frontiers in Bioscience - Landmark
publication_status: published
publisher: Frontiers in Bioscience
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electromagnetic fields and optomechanics In cancer diagnostics and treatment
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 23
year: '2018'
...
---
_id: '425'
abstract:
- lang: eng
text: 'We show that the following algorithmic problem is decidable: given a 2-dimensional
simplicial complex, can it be embedded (topologically, or equivalently, piecewise
linearly) in R3? By a known reduction, it suffices to decide the embeddability
of a given triangulated 3-manifold X into the 3-sphere S3. The main step, which
allows us to simplify X and recurse, is in proving that if X can be embedded in
S3, then there is also an embedding in which X has a short meridian, that is,
an essential curve in the boundary of X bounding a disk in S3 \ X with length
bounded by a computable function of the number of tetrahedra of X.'
article_number: '5'
article_processing_charge: No
article_type: original
author:
- first_name: Jiří
full_name: Matoušek, Jiří
last_name: Matoušek
- first_name: Eric
full_name: Sedgwick, Eric
last_name: Sedgwick
- first_name: Martin
full_name: Tancer, Martin
id: 38AC689C-F248-11E8-B48F-1D18A9856A87
last_name: Tancer
orcid: 0000-0002-1191-6714
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: Matoušek J, Sedgwick E, Tancer M, Wagner U. Embeddability in the 3-Sphere is
decidable. Journal of the ACM. 2018;65(1). doi:10.1145/3078632
apa: Matoušek, J., Sedgwick, E., Tancer, M., & Wagner, U. (2018). Embeddability
in the 3-Sphere is decidable. Journal of the ACM. ACM. https://doi.org/10.1145/3078632
chicago: Matoušek, Jiří, Eric Sedgwick, Martin Tancer, and Uli Wagner. “Embeddability
in the 3-Sphere Is Decidable.” Journal of the ACM. ACM, 2018. https://doi.org/10.1145/3078632.
ieee: J. Matoušek, E. Sedgwick, M. Tancer, and U. Wagner, “Embeddability in the
3-Sphere is decidable,” Journal of the ACM, vol. 65, no. 1. ACM, 2018.
ista: Matoušek J, Sedgwick E, Tancer M, Wagner U. 2018. Embeddability in the 3-Sphere
is decidable. Journal of the ACM. 65(1), 5.
mla: Matoušek, Jiří, et al. “Embeddability in the 3-Sphere Is Decidable.” Journal
of the ACM, vol. 65, no. 1, 5, ACM, 2018, doi:10.1145/3078632.
short: J. Matoušek, E. Sedgwick, M. Tancer, U. Wagner, Journal of the ACM 65 (2018).
date_created: 2018-12-11T11:46:24Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2023-09-11T13:38:49Z
day: '01'
department:
- _id: UlWa
doi: 10.1145/3078632
ec_funded: 1
external_id:
arxiv:
- '1402.0815'
isi:
- '000425685900006'
intvolume: ' 65'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1402.0815
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Journal of the ACM
publication_status: published
publisher: ACM
publist_id: '7398'
quality_controlled: '1'
related_material:
record:
- id: '2157'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Embeddability in the 3-Sphere is decidable
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 65
year: '2018'
...
---
_id: '564'
abstract:
- lang: eng
text: "Maladapted individuals can only colonise a new habitat if they can evolve
a\r\npositive growth rate fast enough to avoid extinction, a process known as
evolutionary\r\nrescue. We treat log fitness at low density in the new habitat
as a\r\nsingle polygenic trait and thus use the infinitesimal model to follow
the evolution\r\nof the growth rate; this assumes that the trait values of offspring
of a\r\nsexual union are normally distributed around the mean of the parents’
trait\r\nvalues, with variance that depends only on the parents’ relatedness.
The\r\nprobability that a single migrant can establish depends on just two parameters:\r\nthe
mean and genetic variance of the trait in the source population.\r\nThe chance
of success becomes small if migrants come from a population\r\nwith mean growth
rate in the new habitat more than a few standard deviations\r\nbelow zero; this
chance depends roughly equally on the probability\r\nthat the initial founder
is unusually fit, and on the subsequent increase in\r\ngrowth rate of its offspring
as a result of selection. The loss of genetic variation\r\nduring the founding
event is substantial, but highly variable. With\r\ncontinued migration at rate
M, establishment is inevitable; when migration\r\nis rare, the expected time to
establishment decreases inversely with M.\r\nHowever, above a threshold migration
rate, the population may be trapped\r\nin a ‘sink’ state, in which adaptation
is held back by gene flow; above this\r\nthreshold, the expected time to establishment
increases exponentially with M. This threshold behaviour is captured by a deterministic
approximation,\r\nwhich assumes a Gaussian distribution of the trait in the founder
population\r\nwith mean and variance evolving deterministically. By assuming a
constant\r\ngenetic variance, we also develop a diffusion approximation for the
joint distribution\r\nof population size and trait mean, which extends to include
stabilising\r\nselection and density regulation. Divergence of the population
from its\r\nancestors causes partial reproductive isolation, which we measure
through\r\nthe reproductive value of migrants into the newly established population."
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Alison
full_name: Etheridge, Alison
last_name: Etheridge
citation:
ama: Barton NH, Etheridge A. Establishment in a new habitat by polygenic adaptation.
Theoretical Population Biology. 2018;122(7):110-127. doi:10.1016/j.tpb.2017.11.007
apa: Barton, N. H., & Etheridge, A. (2018). Establishment in a new habitat by
polygenic adaptation. Theoretical Population Biology. Academic Press. https://doi.org/10.1016/j.tpb.2017.11.007
chicago: Barton, Nicholas H, and Alison Etheridge. “Establishment in a New Habitat
by Polygenic Adaptation.” Theoretical Population Biology. Academic Press,
2018. https://doi.org/10.1016/j.tpb.2017.11.007.
ieee: N. H. Barton and A. Etheridge, “Establishment in a new habitat by polygenic
adaptation,” Theoretical Population Biology, vol. 122, no. 7. Academic
Press, pp. 110–127, 2018.
ista: Barton NH, Etheridge A. 2018. Establishment in a new habitat by polygenic
adaptation. Theoretical Population Biology. 122(7), 110–127.
mla: Barton, Nicholas H., and Alison Etheridge. “Establishment in a New Habitat
by Polygenic Adaptation.” Theoretical Population Biology, vol. 122, no.
7, Academic Press, 2018, pp. 110–27, doi:10.1016/j.tpb.2017.11.007.
short: N.H. Barton, A. Etheridge, Theoretical Population Biology 122 (2018) 110–127.
date_created: 2018-12-11T11:47:12Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2023-09-11T13:41:22Z
day: '01'
ddc:
- '519'
- '576'
department:
- _id: NiBa
doi: 10.1016/j.tpb.2017.11.007
ec_funded: 1
external_id:
isi:
- '000440392900014'
file:
- access_level: open_access
checksum: 0b96f6db47e3e91b5e7d103b847c239d
content_type: application/pdf
creator: nbarton
date_created: 2019-12-21T09:36:39Z
date_updated: 2020-07-14T12:47:09Z
file_id: '7199'
file_name: bartonetheridge.pdf
file_size: 2287682
relation: main_file
file_date_updated: 2020-07-14T12:47:09Z
has_accepted_license: '1'
intvolume: ' 122'
isi: 1
issue: '7'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '07'
oa: 1
oa_version: Submitted Version
page: 110-127
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Theoretical Population Biology
publication_status: published
publisher: Academic Press
publist_id: '7250'
quality_controlled: '1'
related_material:
record:
- id: '9842'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Establishment in a new habitat by polygenic adaptation
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 122
year: '2018'
...
---
_id: '157'
abstract:
- lang: eng
text: 'Social dilemmas occur when incentives for individuals are misaligned with
group interests 1-7 . According to the ''tragedy of the commons'', these misalignments
can lead to overexploitation and collapse of public resources. The resulting behaviours
can be analysed with the tools of game theory 8 . The theory of direct reciprocity
9-15 suggests that repeated interactions can alleviate such dilemmas, but previous
work has assumed that the public resource remains constant over time. Here we
introduce the idea that the public resource is instead changeable and depends
on the strategic choices of individuals. An intuitive scenario is that cooperation
increases the public resource, whereas defection decreases it. Thus, cooperation
allows the possibility of playing a more valuable game with higher payoffs, whereas
defection leads to a less valuable game. We analyse this idea using the theory
of stochastic games 16-19 and evolutionary game theory. We find that the dependence
of the public resource on previous interactions can greatly enhance the propensity
for cooperation. For these results, the interaction between reciprocity and payoff
feedback is crucial: neither repeated interactions in a constant environment nor
single interactions in a changing environment yield similar cooperation rates.
Our framework shows which feedbacks between exploitation and environment - either
naturally occurring or designed - help to overcome social dilemmas.'
acknowledgement: "European Research Council Start Grant 279307, Austrian Science Fund
(FWF) grant P23499-N23, \r\nC.H. acknowledges support from the ISTFELLOW programme."
article_processing_charge: No
author:
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Štepán
full_name: Šimsa, Štepán
last_name: Šimsa
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Hilbe C, Šimsa Š, Chatterjee K, Nowak M. Evolution of cooperation in stochastic
games. Nature. 2018;559(7713):246-249. doi:10.1038/s41586-018-0277-x
apa: Hilbe, C., Šimsa, Š., Chatterjee, K., & Nowak, M. (2018). Evolution of
cooperation in stochastic games. Nature. Nature Publishing Group. https://doi.org/10.1038/s41586-018-0277-x
chicago: Hilbe, Christian, Štepán Šimsa, Krishnendu Chatterjee, and Martin Nowak.
“Evolution of Cooperation in Stochastic Games.” Nature. Nature Publishing
Group, 2018. https://doi.org/10.1038/s41586-018-0277-x.
ieee: C. Hilbe, Š. Šimsa, K. Chatterjee, and M. Nowak, “Evolution of cooperation
in stochastic games,” Nature, vol. 559, no. 7713. Nature Publishing Group,
pp. 246–249, 2018.
ista: Hilbe C, Šimsa Š, Chatterjee K, Nowak M. 2018. Evolution of cooperation in
stochastic games. Nature. 559(7713), 246–249.
mla: Hilbe, Christian, et al. “Evolution of Cooperation in Stochastic Games.” Nature,
vol. 559, no. 7713, Nature Publishing Group, 2018, pp. 246–49, doi:10.1038/s41586-018-0277-x.
short: C. Hilbe, Š. Šimsa, K. Chatterjee, M. Nowak, Nature 559 (2018) 246–249.
date_created: 2018-12-11T11:44:56Z
date_published: 2018-07-04T00:00:00Z
date_updated: 2023-09-11T13:43:22Z
day: '04'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1038/s41586-018-0277-x
ec_funded: 1
external_id:
isi:
- '000438240900054'
file:
- access_level: open_access
checksum: 011ab905cf9a410bc2b96f15174d654d
content_type: application/pdf
creator: dernst
date_created: 2019-11-19T08:09:57Z
date_updated: 2020-07-14T12:45:02Z
file_id: '7049'
file_name: 2018_Nature_Hilbe.pdf
file_size: 2834442
relation: main_file
file_date_updated: 2020-07-14T12:45:02Z
has_accepted_license: '1'
intvolume: ' 559'
isi: 1
issue: '7713'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 246 - 249
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '7764'
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/engineering-cooperation/
scopus_import: '1'
status: public
title: Evolution of cooperation in stochastic games
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 559
year: '2018'
...
---
_id: '384'
abstract:
- lang: eng
text: Can orthologous proteins differ in terms of their ability to be secreted?
To answer this question, we investigated the distribution of signal peptides within
the orthologous groups of Enterobacterales. Parsimony analysis and sequence comparisons
revealed a large number of signal peptide gain and loss events, in which signal
peptides emerge or disappear in the course of evolution. Signal peptide losses
prevail over gains, an effect which is especially pronounced in the transition
from the free-living or commensal to the endosymbiotic lifestyle. The disproportionate
decline in the number of signal peptide-containing proteins in endosymbionts cannot
be explained by the overall reduction of their genomes. Signal peptides can be
gained and lost either by acquisition/elimination of the corresponding N-terminal
regions or by gradual accumulation of mutations. The evolutionary dynamics of
signal peptides in bacterial proteins represents a powerful mechanism of functional
diversification.
acknowledgement: "his work was supported by the Deutsche Forschungsgemeinschaft (grant
\ number FR 1411/9-1). This work was supported by the German Research Foundation
(DFG) and the Technical University of Munich within the fund- ing programme Open
Access Publish\r\nWe thank Goar Frishman for help with the annotation of the\r\nsymbiont
status of the organisms and Michael Galperin for\r\nuseful comments. T"
article_processing_charge: No
author:
- first_name: Peter
full_name: Hönigschmid, Peter
last_name: Hönigschmid
- first_name: Nadya
full_name: Bykova, Nadya
last_name: Bykova
- first_name: René
full_name: Schneider, René
last_name: Schneider
- first_name: Dmitry
full_name: Ivankov, Dmitry
id: 49FF1036-F248-11E8-B48F-1D18A9856A87
last_name: Ivankov
- first_name: Dmitrij
full_name: Frishman, Dmitrij
last_name: Frishman
citation:
ama: Hönigschmid P, Bykova N, Schneider R, Ivankov D, Frishman D. Evolutionary interplay
between symbiotic relationships and patterns of signal peptide gain and loss.
Genome Biology and Evolution. 2018;10(3):928-938. doi:10.1093/gbe/evy049
apa: Hönigschmid, P., Bykova, N., Schneider, R., Ivankov, D., & Frishman, D.
(2018). Evolutionary interplay between symbiotic relationships and patterns of
signal peptide gain and loss. Genome Biology and Evolution. Oxford University
Press. https://doi.org/10.1093/gbe/evy049
chicago: Hönigschmid, Peter, Nadya Bykova, René Schneider, Dmitry Ivankov, and Dmitrij
Frishman. “Evolutionary Interplay between Symbiotic Relationships and Patterns
of Signal Peptide Gain and Loss.” Genome Biology and Evolution. Oxford
University Press, 2018. https://doi.org/10.1093/gbe/evy049.
ieee: P. Hönigschmid, N. Bykova, R. Schneider, D. Ivankov, and D. Frishman, “Evolutionary
interplay between symbiotic relationships and patterns of signal peptide gain
and loss,” Genome Biology and Evolution, vol. 10, no. 3. Oxford University
Press, pp. 928–938, 2018.
ista: Hönigschmid P, Bykova N, Schneider R, Ivankov D, Frishman D. 2018. Evolutionary
interplay between symbiotic relationships and patterns of signal peptide gain
and loss. Genome Biology and Evolution. 10(3), 928–938.
mla: Hönigschmid, Peter, et al. “Evolutionary Interplay between Symbiotic Relationships
and Patterns of Signal Peptide Gain and Loss.” Genome Biology and Evolution,
vol. 10, no. 3, Oxford University Press, 2018, pp. 928–38, doi:10.1093/gbe/evy049.
short: P. Hönigschmid, N. Bykova, R. Schneider, D. Ivankov, D. Frishman, Genome
Biology and Evolution 10 (2018) 928–938.
date_created: 2018-12-11T11:46:10Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2023-09-11T13:56:52Z
day: '01'
ddc:
- '576'
department:
- _id: FyKo
doi: 10.1093/gbe/evy049
external_id:
isi:
- '000429483700022'
file:
- access_level: open_access
checksum: 458a7c2c2e79528567edfeb0f326cbe0
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:07Z
date_updated: 2020-07-14T12:46:16Z
file_id: '4667'
file_name: IST-2018-999-v1+1_2018_Ivankov_Evolutionary_interplay.pdf
file_size: 691602
relation: main_file
file_date_updated: 2020-07-14T12:46:16Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: 928 - 938
publication: Genome Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '7445'
pubrep_id: '999'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolutionary interplay between symbiotic relationships and patterns of signal
peptide gain and loss
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10
year: '2018'
...
---
_id: '563'
abstract:
- lang: eng
text: "In continuous populations with local migration, nearby pairs of individuals
have on average more similar genotypes\r\nthan geographically well separated pairs.
A barrier to gene flow distorts this classical pattern of isolation by distance.
Genetic similarity is decreased for sample pairs on different sides of the barrier
and increased for pairs on the same side near the barrier. Here, we introduce
an inference scheme that utilizes this signal to detect and estimate the strength
of a linear barrier to gene flow in two-dimensions. We use a diffusion approximation
to model the effects of a barrier on the geographical spread of ancestry backwards
in time. This approach allows us to calculate the chance of recent coalescence
and probability of identity by descent. We introduce an inference scheme that
fits these theoretical results to the geographical covariance structure of bialleleic
genetic markers. It can estimate the strength of the barrier as well as several
demographic parameters. We investigate the power of our inference scheme to detect
barriers by applying it to a wide range of simulated data. We also showcase an
example application to a Antirrhinum majus (snapdragon) flower color hybrid zone,
where we do not detect any signal of a strong genome wide barrier to gene flow."
article_processing_charge: No
author:
- first_name: Harald
full_name: Ringbauer, Harald
id: 417FCFF4-F248-11E8-B48F-1D18A9856A87
last_name: Ringbauer
orcid: 0000-0002-4884-9682
- first_name: Alexander
full_name: Kolesnikov, Alexander
id: 2D157DB6-F248-11E8-B48F-1D18A9856A87
last_name: Kolesnikov
- first_name: David
full_name: Field, David
last_name: Field
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Ringbauer H, Kolesnikov A, Field D, Barton NH. Estimating barriers to gene
flow from distorted isolation-by-distance patterns. Genetics. 2018;208(3):1231-1245.
doi:10.1534/genetics.117.300638
apa: Ringbauer, H., Kolesnikov, A., Field, D., & Barton, N. H. (2018). Estimating
barriers to gene flow from distorted isolation-by-distance patterns. Genetics.
Genetics Society of America. https://doi.org/10.1534/genetics.117.300638
chicago: Ringbauer, Harald, Alexander Kolesnikov, David Field, and Nicholas H Barton.
“Estimating Barriers to Gene Flow from Distorted Isolation-by-Distance Patterns.”
Genetics. Genetics Society of America, 2018. https://doi.org/10.1534/genetics.117.300638.
ieee: H. Ringbauer, A. Kolesnikov, D. Field, and N. H. Barton, “Estimating barriers
to gene flow from distorted isolation-by-distance patterns,” Genetics,
vol. 208, no. 3. Genetics Society of America, pp. 1231–1245, 2018.
ista: Ringbauer H, Kolesnikov A, Field D, Barton NH. 2018. Estimating barriers to
gene flow from distorted isolation-by-distance patterns. Genetics. 208(3), 1231–1245.
mla: Ringbauer, Harald, et al. “Estimating Barriers to Gene Flow from Distorted
Isolation-by-Distance Patterns.” Genetics, vol. 208, no. 3, Genetics Society
of America, 2018, pp. 1231–45, doi:10.1534/genetics.117.300638.
short: H. Ringbauer, A. Kolesnikov, D. Field, N.H. Barton, Genetics 208 (2018) 1231–1245.
date_created: 2018-12-11T11:47:12Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2023-09-11T13:42:38Z
day: '01'
department:
- _id: NiBa
- _id: ChLa
doi: 10.1534/genetics.117.300638
external_id:
isi:
- '000426219600025'
intvolume: ' 208'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/205484v1
month: '03'
oa: 1
oa_version: Preprint
page: 1231-1245
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '7251'
quality_controlled: '1'
related_material:
record:
- id: '200'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Estimating barriers to gene flow from distorted isolation-by-distance patterns
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 208
year: '2018'
...
---
_id: '135'
abstract:
- lang: eng
text: The Fluid Implicit Particle method (FLIP) reduces numerical dissipation by
combining particles with grids. To improve performance, the subsequent narrow
band FLIP method (NB‐FLIP) uses a FLIP‐based fluid simulation only near the liquid
surface and a traditional grid‐based fluid simulation away from the surface. This
spatially‐limited FLIP simulation significantly reduces the number of particles
and alleviates a computational bottleneck. In this paper, we extend the NB‐FLIP
idea even further, by allowing a simulation to transition between a FLIP‐like
fluid simulation and a grid‐based simulation in arbitrary locations, not just
near the surface. This approach leads to even more savings in memory and computation,
because we can concentrate the particles only in areas where they are needed.
More importantly, this new method allows us to seamlessly transition to smooth
implicit surface geometry wherever the particle‐based simulation is unnecessary.
Consequently, our method leads to a practical algorithm for avoiding the noisy
surface artifacts associated with particle‐based liquid simulations, while simultaneously
maintaining the benefits of a FLIP simulation in regions of dynamic motion.
alternative_title:
- Eurographics
article_processing_charge: No
article_type: original
author:
- first_name: Takahiro
full_name: Sato, Takahiro
last_name: Sato
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
- first_name: Nils
full_name: Thuerey, Nils
last_name: Thuerey
- first_name: Takeo
full_name: Igarashi, Takeo
last_name: Igarashi
- first_name: Ryoichi
full_name: Ando, Ryoichi
last_name: Ando
citation:
ama: Sato T, Wojtan C, Thuerey N, Igarashi T, Ando R. Extended narrow band FLIP
for liquid simulations. Computer Graphics Forum. 2018;37(2):169-177. doi:10.1111/cgf.13351
apa: Sato, T., Wojtan, C., Thuerey, N., Igarashi, T., & Ando, R. (2018). Extended
narrow band FLIP for liquid simulations. Computer Graphics Forum. Wiley.
https://doi.org/10.1111/cgf.13351
chicago: Sato, Takahiro, Chris Wojtan, Nils Thuerey, Takeo Igarashi, and Ryoichi
Ando. “Extended Narrow Band FLIP for Liquid Simulations.” Computer Graphics
Forum. Wiley, 2018. https://doi.org/10.1111/cgf.13351.
ieee: T. Sato, C. Wojtan, N. Thuerey, T. Igarashi, and R. Ando, “Extended narrow
band FLIP for liquid simulations,” Computer Graphics Forum, vol. 37, no.
2. Wiley, pp. 169–177, 2018.
ista: Sato T, Wojtan C, Thuerey N, Igarashi T, Ando R. 2018. Extended narrow band
FLIP for liquid simulations. Computer Graphics Forum. 37(2), 169–177.
mla: Sato, Takahiro, et al. “Extended Narrow Band FLIP for Liquid Simulations.”
Computer Graphics Forum, vol. 37, no. 2, Wiley, 2018, pp. 169–77, doi:10.1111/cgf.13351.
short: T. Sato, C. Wojtan, N. Thuerey, T. Igarashi, R. Ando, Computer Graphics Forum
37 (2018) 169–177.
date_created: 2018-12-11T11:44:49Z
date_published: 2018-05-22T00:00:00Z
date_updated: 2023-09-11T14:00:26Z
day: '22'
ddc:
- '006'
department:
- _id: ChWo
doi: 10.1111/cgf.13351
ec_funded: 1
external_id:
isi:
- '000434085600016'
file:
- access_level: open_access
checksum: 8edb90da8a72395eb5d970580e0925b6
content_type: application/pdf
creator: wojtan
date_created: 2020-10-08T08:38:23Z
date_updated: 2020-10-08T08:38:23Z
file_id: '8627'
file_name: exnbflip.pdf
file_size: 54309947
relation: main_file
success: 1
file_date_updated: 2020-10-08T08:38:23Z
has_accepted_license: '1'
intvolume: ' 37'
isi: 1
issue: '2'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 169 - 177
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: Efficient Simulation of Natural Phenomena at Extremely Large Scales
publication: Computer Graphics Forum
publication_identifier:
issn:
- 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extended narrow band FLIP for liquid simulations
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 37
year: '2018'
...
---
_id: '316'
abstract:
- lang: eng
text: 'Self-incompatibility (SI) is a genetically based recognition system that
functions to prevent self-fertilization and mating among related plants. An enduring
puzzle in SI is how the high diversity observed in nature arises and is maintained.
Based on the underlying recognition mechanism, SI can be classified into two main
groups: self- and non-self recognition. Most work has focused on diversification
within self-recognition systems despite expected differences between the two groups
in the evolutionary pathways and outcomes of diversification. Here, we use a deterministic
population genetic model and stochastic simulations to investigate how novel S-haplotypes
evolve in a gametophytic non-self recognition (SRNase/S Locus F-box (SLF)) SI
system. For this model the pathways for diversification involve either the maintenance
or breakdown of SI and can vary in the order of mutations of the female (SRNase)
and male (SLF) components. We show analytically that diversification can occur
with high inbreeding depression and self-pollination, but this varies with evolutionary
pathway and level of completeness (which determines the number of potential mating
partners in the population), and in general is more likely for lower haplotype
number. The conditions for diversification are broader in stochastic simulations
of finite population size. However, the number of haplotypes observed under high
inbreeding and moderate to high self-pollination is less than that commonly observed
in nature. Diversification was observed through pathways that maintain SI as well
as through self-compatible intermediates. Yet the lifespan of diversified haplotypes
was sensitive to their level of completeness. By examining diversification in
a non-self recognition SI system, this model extends our understanding of the
evolution and maintenance of haplotype diversity observed in a self recognition
system common in flowering plants.'
article_processing_charge: No
article_type: original
author:
- first_name: Katarina
full_name: Bodova, Katarina
id: 2BA24EA0-F248-11E8-B48F-1D18A9856A87
last_name: Bodova
orcid: 0000-0002-7214-0171
- first_name: Tadeas
full_name: Priklopil, Tadeas
id: 3C869AA0-F248-11E8-B48F-1D18A9856A87
last_name: Priklopil
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
citation:
ama: Bodova K, Priklopil T, Field D, Barton NH, Pickup M. Evolutionary pathways
for the generation of new self-incompatibility haplotypes in a non-self recognition
system. Genetics. 2018;209(3):861-883. doi:10.1534/genetics.118.300748
apa: Bodova, K., Priklopil, T., Field, D., Barton, N. H., & Pickup, M. (2018).
Evolutionary pathways for the generation of new self-incompatibility haplotypes
in a non-self recognition system. Genetics. Genetics Society of America.
https://doi.org/10.1534/genetics.118.300748
chicago: Bodova, Katarina, Tadeas Priklopil, David Field, Nicholas H Barton, and
Melinda Pickup. “Evolutionary Pathways for the Generation of New Self-Incompatibility
Haplotypes in a Non-Self Recognition System.” Genetics. Genetics Society
of America, 2018. https://doi.org/10.1534/genetics.118.300748.
ieee: K. Bodova, T. Priklopil, D. Field, N. H. Barton, and M. Pickup, “Evolutionary
pathways for the generation of new self-incompatibility haplotypes in a non-self
recognition system,” Genetics, vol. 209, no. 3. Genetics Society of America,
pp. 861–883, 2018.
ista: Bodova K, Priklopil T, Field D, Barton NH, Pickup M. 2018. Evolutionary pathways
for the generation of new self-incompatibility haplotypes in a non-self recognition
system. Genetics. 209(3), 861–883.
mla: Bodova, Katarina, et al. “Evolutionary Pathways for the Generation of New Self-Incompatibility
Haplotypes in a Non-Self Recognition System.” Genetics, vol. 209, no. 3,
Genetics Society of America, 2018, pp. 861–83, doi:10.1534/genetics.118.300748.
short: K. Bodova, T. Priklopil, D. Field, N.H. Barton, M. Pickup, Genetics 209 (2018)
861–883.
date_created: 2018-12-11T11:45:47Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2023-09-11T13:57:43Z
day: '01'
department:
- _id: NiBa
- _id: GaTk
doi: 10.1534/genetics.118.300748
ec_funded: 1
external_id:
isi:
- '000437171700017'
intvolume: ' 209'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/node/80098.abstract
month: '07'
oa: 1
oa_version: Preprint
page: 861-883
project:
- _id: 25B36484-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '329960'
name: Mating system and the evolutionary dynamics of hybrid zones
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Genetics
publication_status: published
publisher: Genetics Society of America
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/recognizing-others-but-not-yourself-new-insights-into-the-evolution-of-plant-mating/
record:
- id: '9813'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Evolutionary pathways for the generation of new self-incompatibility haplotypes
in a non-self recognition system
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 209
year: '2018'
...
---
_id: '190'
abstract:
- lang: eng
text: The German cockroach, Blattella germanica, is a worldwide pest that infests
buildings, including homes, restaurants, and hospitals, often living in unsanitary
conditions. As a disease vector and producer of allergens, this species has major
health and economic impacts on humans. Factors contributing to the success of
the German cockroach include its resistance to a broad range of insecticides,
immunity to many pathogens, and its ability, as an extreme generalist omnivore,
to survive on most food sources. The recently published genome shows that B. germanica
has an exceptionally high number of protein coding genes. In this study, we investigate
the functions of the 93 significantly expanded gene families with the aim to better
understand the success of B. germanica as a major pest despite such inhospitable
conditions. We find major expansions in gene families with functions related to
the detoxification of insecticides and allelochemicals, defense against pathogens,
digestion, sensory perception, and gene regulation. These expansions might have
allowed B. germanica to develop multiple resistance mechanisms to insecticides
and pathogens, and enabled a broad, flexible diet, thus explaining its success
in unsanitary conditions and under recurrent chemical control. The findings and
resources presented here provide insights for better understanding molecular mechanisms
that will facilitate more effective cockroach control.
article_processing_charge: No
article_type: original
author:
- first_name: Mark
full_name: Harrison, Mark
last_name: Harrison
- first_name: Nicolas
full_name: Arning, Nicolas
last_name: Arning
- first_name: Lucas
full_name: Kremer, Lucas
last_name: Kremer
- first_name: Guillem
full_name: Ylla, Guillem
last_name: Ylla
- first_name: Xavier
full_name: Belles, Xavier
last_name: Belles
- first_name: Erich
full_name: Bornberg Bauer, Erich
last_name: Bornberg Bauer
- first_name: Ann K
full_name: Huylmans, Ann K
id: 4C0A3874-F248-11E8-B48F-1D18A9856A87
last_name: Huylmans
orcid: 0000-0001-8871-4961
- first_name: Evelien
full_name: Jongepier, Evelien
last_name: Jongepier
- first_name: Maria
full_name: Puilachs, Maria
last_name: Puilachs
- first_name: Stephen
full_name: Richards, Stephen
last_name: Richards
- first_name: Coby
full_name: Schal, Coby
last_name: Schal
citation:
ama: 'Harrison M, Arning N, Kremer L, et al. Expansions of key protein families
in the German cockroach highlight the molecular basis of its remarkable success
as a global indoor pest. Journal of Experimental Zoology Part B: Molecular
and Developmental Evolution. 2018;330:254-264. doi:10.1002/jez.b.22824'
apa: 'Harrison, M., Arning, N., Kremer, L., Ylla, G., Belles, X., Bornberg Bauer,
E., … Schal, C. (2018). Expansions of key protein families in the German cockroach
highlight the molecular basis of its remarkable success as a global indoor pest.
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
Wiley. https://doi.org/10.1002/jez.b.22824'
chicago: 'Harrison, Mark, Nicolas Arning, Lucas Kremer, Guillem Ylla, Xavier Belles,
Erich Bornberg Bauer, Ann K Huylmans, et al. “Expansions of Key Protein Families
in the German Cockroach Highlight the Molecular Basis of Its Remarkable Success
as a Global Indoor Pest.” Journal of Experimental Zoology Part B: Molecular
and Developmental Evolution. Wiley, 2018. https://doi.org/10.1002/jez.b.22824.'
ieee: 'M. Harrison et al., “Expansions of key protein families in the German
cockroach highlight the molecular basis of its remarkable success as a global
indoor pest,” Journal of Experimental Zoology Part B: Molecular and Developmental
Evolution, vol. 330. Wiley, pp. 254–264, 2018.'
ista: 'Harrison M, Arning N, Kremer L, Ylla G, Belles X, Bornberg Bauer E, Huylmans
AK, Jongepier E, Puilachs M, Richards S, Schal C. 2018. Expansions of key protein
families in the German cockroach highlight the molecular basis of its remarkable
success as a global indoor pest. Journal of Experimental Zoology Part B: Molecular
and Developmental Evolution. 330, 254–264.'
mla: 'Harrison, Mark, et al. “Expansions of Key Protein Families in the German Cockroach
Highlight the Molecular Basis of Its Remarkable Success as a Global Indoor Pest.”
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution,
vol. 330, Wiley, 2018, pp. 254–64, doi:10.1002/jez.b.22824.'
short: 'M. Harrison, N. Arning, L. Kremer, G. Ylla, X. Belles, E. Bornberg Bauer,
A.K. Huylmans, E. Jongepier, M. Puilachs, S. Richards, C. Schal, Journal of Experimental
Zoology Part B: Molecular and Developmental Evolution 330 (2018) 254–264.'
date_created: 2018-12-11T11:45:06Z
date_published: 2018-07-11T00:00:00Z
date_updated: 2023-09-11T13:59:54Z
day: '11'
department:
- _id: BeVi
doi: 10.1002/jez.b.22824
external_id:
isi:
- '000443231000002'
pmid:
- '29998472'
intvolume: ' 330'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/jez.b.22824
month: '07'
oa: 1
oa_version: Submitted Version
page: 254-264
pmid: 1
publication: 'Journal of Experimental Zoology Part B: Molecular and Developmental
Evolution'
publication_status: published
publisher: Wiley
publist_id: '7730'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expansions of key protein families in the German cockroach highlight the molecular
basis of its remarkable success as a global indoor pest
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 330
year: '2018'
...
---
_id: '404'
abstract:
- lang: eng
text: "We construct martingale solutions to stochastic thin-film equations by introducing
a (spatial) semidiscretization and establishing convergence. The discrete scheme
allows for variants of the energy and entropy estimates in the continuous setting
as long as the discrete energy does not exceed certain threshold values depending
on the spatial grid size $h$. Using a stopping time argument to prolongate high-energy
paths constant in time, arbitrary moments of coupled energy/entropy functionals
can be controlled. Having established Hölder regularity of approximate solutions,
the convergence proof is then based on compactness arguments---in particular on
Jakubowski's generalization of Skorokhod's theorem---weak convergence methods,
and recent tools on martingale convergence.\r\n\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
- first_name: Günther
full_name: Grün, Günther
last_name: Grün
citation:
ama: Fischer JL, Grün G. Existence of positive solutions to stochastic thin-film
equations. SIAM Journal on Mathematical Analysis. 2018;50(1):411-455. doi:10.1137/16M1098796
apa: Fischer, J. L., & Grün, G. (2018). Existence of positive solutions to stochastic
thin-film equations. SIAM Journal on Mathematical Analysis. Society for
Industrial and Applied Mathematics . https://doi.org/10.1137/16M1098796
chicago: Fischer, Julian L, and Günther Grün. “Existence of Positive Solutions to
Stochastic Thin-Film Equations.” SIAM Journal on Mathematical Analysis.
Society for Industrial and Applied Mathematics , 2018. https://doi.org/10.1137/16M1098796.
ieee: J. L. Fischer and G. Grün, “Existence of positive solutions to stochastic
thin-film equations,” SIAM Journal on Mathematical Analysis, vol. 50, no.
1. Society for Industrial and Applied Mathematics , pp. 411–455, 2018.
ista: Fischer JL, Grün G. 2018. Existence of positive solutions to stochastic thin-film
equations. SIAM Journal on Mathematical Analysis. 50(1), 411–455.
mla: Fischer, Julian L., and Günther Grün. “Existence of Positive Solutions to Stochastic
Thin-Film Equations.” SIAM Journal on Mathematical Analysis, vol. 50, no.
1, Society for Industrial and Applied Mathematics , 2018, pp. 411–55, doi:10.1137/16M1098796.
short: J.L. Fischer, G. Grün, SIAM Journal on Mathematical Analysis 50 (2018) 411–455.
date_created: 2018-12-11T11:46:17Z
date_published: 2018-01-30T00:00:00Z
date_updated: 2023-09-11T13:59:22Z
day: '30'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1137/16M1098796
external_id:
isi:
- '000426630900015'
file:
- access_level: open_access
checksum: 89a8eae7c52bb356c04f52b44bff4b5a
content_type: application/pdf
creator: dernst
date_created: 2019-11-07T12:20:25Z
date_updated: 2020-07-14T12:46:22Z
file_id: '6992'
file_name: 2018_SIAM_Fischer.pdf
file_size: 557338
relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
has_accepted_license: '1'
intvolume: ' 50'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 411 - 455
publication: SIAM Journal on Mathematical Analysis
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '7425'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Existence of positive solutions to stochastic thin-film equations
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 50
year: '2018'
...
---
_id: '9813'
abstract:
- lang: eng
text: 'File S1 contains figures that clarify the following features: (i) effect
of population size on the average number/frequency of SI classes, (ii) changes
in the minimal completeness deficit in time for a single class, and (iii) diversification
diagrams for all studied pathways, including the summary figure for k = 8. File
S2 contains the code required for a stochastic simulation of the SLF system with
an example. This file also includes the output in the form of figures and tables.'
article_processing_charge: No
author:
- first_name: Katarína
full_name: Bod'ová, Katarína
id: 2BA24EA0-F248-11E8-B48F-1D18A9856A87
last_name: Bod'ová
orcid: 0000-0002-7214-0171
- first_name: Tadeas
full_name: Priklopil, Tadeas
id: 3C869AA0-F248-11E8-B48F-1D18A9856A87
last_name: Priklopil
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
citation:
ama: Bodova K, Priklopil T, Field D, Barton NH, Pickup M. Supplemental material
for Bodova et al., 2018. 2018. doi:10.25386/genetics.6148304.v1
apa: Bodova, K., Priklopil, T., Field, D., Barton, N. H., & Pickup, M. (2018).
Supplemental material for Bodova et al., 2018. Genetics Society of America. https://doi.org/10.25386/genetics.6148304.v1
chicago: Bodova, Katarina, Tadeas Priklopil, David Field, Nicholas H Barton, and
Melinda Pickup. “Supplemental Material for Bodova et Al., 2018.” Genetics Society
of America, 2018. https://doi.org/10.25386/genetics.6148304.v1.
ieee: K. Bodova, T. Priklopil, D. Field, N. H. Barton, and M. Pickup, “Supplemental
material for Bodova et al., 2018.” Genetics Society of America, 2018.
ista: Bodova K, Priklopil T, Field D, Barton NH, Pickup M. 2018. Supplemental material
for Bodova et al., 2018, Genetics Society of America, 10.25386/genetics.6148304.v1.
mla: Bodova, Katarina, et al. Supplemental Material for Bodova et Al., 2018.
Genetics Society of America, 2018, doi:10.25386/genetics.6148304.v1.
short: K. Bodova, T. Priklopil, D. Field, N.H. Barton, M. Pickup, (2018).
date_created: 2021-08-06T13:04:32Z
date_published: 2018-04-30T00:00:00Z
date_updated: 2023-09-11T13:57:42Z
day: '30'
department:
- _id: NiBa
- _id: GaTk
doi: 10.25386/genetics.6148304.v1
main_file_link:
- open_access: '1'
url: https://doi.org/10.25386/genetics.6148304.v1
month: '04'
oa: 1
oa_version: Published Version
publisher: Genetics Society of America
related_material:
record:
- id: '316'
relation: used_in_publication
status: public
status: public
title: Supplemental material for Bodova et al., 2018
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2018'
...
---
_id: '5780'
abstract:
- lang: eng
text: Bioluminescence is found across the entire tree of life, conferring a spectacular
set of visually oriented functions from attracting mates to scaring off predators.
Half a dozen different luciferins, molecules that emit light when enzymatically
oxidized, are known. However, just one biochemical pathway for luciferin biosynthesis
has been described in full, which is found only in bacteria. Here, we report identification
of the fungal luciferase and three other key enzymes that together form the biosynthetic
cycle of the fungal luciferin from caffeic acid, a simple and widespread metabolite.
Introduction of the identified genes into the genome of the yeast Pichia pastoris
along with caffeic acid biosynthesis genes resulted in a strain that is autoluminescent
in standard media. We analyzed evolution of the enzymes of the luciferin biosynthesis
cycle and found that fungal bioluminescence emerged through a series of events
that included two independent gene duplications. The retention of the duplicated
enzymes of the luciferin pathway in nonluminescent fungi shows that the gene duplication
was followed by functional sequence divergence of enzymes of at least one gene
in the biosynthetic pathway and suggests that the evolution of fungal bioluminescence
proceeded through several closely related stepping stone nonluminescent biochemical
reactions with adaptive roles. The availability of a complete eukaryotic luciferin
biosynthesis pathway provides several applications in biomedicine and bioengineering.
article_processing_charge: No
author:
- first_name: Alexey A.
full_name: Kotlobay, Alexey A.
last_name: Kotlobay
- first_name: Karen
full_name: Sarkisyan, Karen
id: 39A7BF80-F248-11E8-B48F-1D18A9856A87
last_name: Sarkisyan
orcid: 0000-0002-5375-6341
- first_name: Yuliana A.
full_name: Mokrushina, Yuliana A.
last_name: Mokrushina
- first_name: Marina
full_name: Marcet-Houben, Marina
last_name: Marcet-Houben
- first_name: Ekaterina O.
full_name: Serebrovskaya, Ekaterina O.
last_name: Serebrovskaya
- first_name: Nadezhda M.
full_name: Markina, Nadezhda M.
last_name: Markina
- first_name: Louisa
full_name: Gonzalez Somermeyer, Louisa
id: 4720D23C-F248-11E8-B48F-1D18A9856A87
last_name: Gonzalez Somermeyer
orcid: 0000-0001-9139-5383
- first_name: Andrey Y.
full_name: Gorokhovatsky, Andrey Y.
last_name: Gorokhovatsky
- first_name: Andrey
full_name: Vvedensky, Andrey
last_name: Vvedensky
- first_name: Konstantin V.
full_name: Purtov, Konstantin V.
last_name: Purtov
- first_name: Valentin N.
full_name: Petushkov, Valentin N.
last_name: Petushkov
- first_name: Natalja S.
full_name: Rodionova, Natalja S.
last_name: Rodionova
- first_name: Tatiana V.
full_name: Chepurnyh, Tatiana V.
last_name: Chepurnyh
- first_name: Liliia
full_name: Fakhranurova, Liliia
last_name: Fakhranurova
- first_name: Elena B.
full_name: Guglya, Elena B.
last_name: Guglya
- first_name: Rustam
full_name: Ziganshin, Rustam
last_name: Ziganshin
- first_name: Aleksandra S.
full_name: Tsarkova, Aleksandra S.
last_name: Tsarkova
- first_name: Zinaida M.
full_name: Kaskova, Zinaida M.
last_name: Kaskova
- first_name: Victoria
full_name: Shender, Victoria
last_name: Shender
- first_name: Maxim
full_name: Abakumov, Maxim
last_name: Abakumov
- first_name: Tatiana O.
full_name: Abakumova, Tatiana O.
last_name: Abakumova
- first_name: Inna S.
full_name: Povolotskaya, Inna S.
last_name: Povolotskaya
- first_name: Fedor M.
full_name: Eroshkin, Fedor M.
last_name: Eroshkin
- first_name: Andrey G.
full_name: Zaraisky, Andrey G.
last_name: Zaraisky
- first_name: Alexander S.
full_name: Mishin, Alexander S.
last_name: Mishin
- first_name: Sergey V.
full_name: Dolgov, Sergey V.
last_name: Dolgov
- first_name: Tatiana Y.
full_name: Mitiouchkina, Tatiana Y.
last_name: Mitiouchkina
- first_name: Eugene P.
full_name: Kopantzev, Eugene P.
last_name: Kopantzev
- first_name: Hans E.
full_name: Waldenmaier, Hans E.
last_name: Waldenmaier
- first_name: Anderson G.
full_name: Oliveira, Anderson G.
last_name: Oliveira
- first_name: Yuichi
full_name: Oba, Yuichi
last_name: Oba
- first_name: Ekaterina
full_name: Barsova, Ekaterina
last_name: Barsova
- first_name: Ekaterina A.
full_name: Bogdanova, Ekaterina A.
last_name: Bogdanova
- first_name: Toni
full_name: Gabaldón, Toni
last_name: Gabaldón
- first_name: Cassius V.
full_name: Stevani, Cassius V.
last_name: Stevani
- first_name: Sergey
full_name: Lukyanov, Sergey
last_name: Lukyanov
- first_name: Ivan V.
full_name: Smirnov, Ivan V.
last_name: Smirnov
- first_name: Josef I.
full_name: Gitelson, Josef I.
last_name: Gitelson
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Ilia V.
full_name: Yampolsky, Ilia V.
last_name: Yampolsky
citation:
ama: Kotlobay AA, Sarkisyan K, Mokrushina YA, et al. Genetically encodable bioluminescent
system from fungi. Proceedings of the National Academy of Sciences of the United
States of America. 2018;115(50):12728-12732. doi:10.1073/pnas.1803615115
apa: Kotlobay, A. A., Sarkisyan, K., Mokrushina, Y. A., Marcet-Houben, M., Serebrovskaya,
E. O., Markina, N. M., … Yampolsky, I. V. (2018). Genetically encodable bioluminescent
system from fungi. Proceedings of the National Academy of Sciences of the United
States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.1803615115
chicago: Kotlobay, Alexey A., Karen Sarkisyan, Yuliana A. Mokrushina, Marina Marcet-Houben,
Ekaterina O. Serebrovskaya, Nadezhda M. Markina, Louisa Gonzalez Somermeyer, et
al. “Genetically Encodable Bioluminescent System from Fungi.” Proceedings of
the National Academy of Sciences of the United States of America. National
Academy of Sciences, 2018. https://doi.org/10.1073/pnas.1803615115.
ieee: A. A. Kotlobay et al., “Genetically encodable bioluminescent system
from fungi,” Proceedings of the National Academy of Sciences of the United
States of America, vol. 115, no. 50. National Academy of Sciences, pp. 12728–12732,
2018.
ista: Kotlobay AA, Sarkisyan K, Mokrushina YA, Marcet-Houben M, Serebrovskaya EO,
Markina NM, Gonzalez Somermeyer L, Gorokhovatsky AY, Vvedensky A, Purtov KV, Petushkov
VN, Rodionova NS, Chepurnyh TV, Fakhranurova L, Guglya EB, Ziganshin R, Tsarkova
AS, Kaskova ZM, Shender V, Abakumov M, Abakumova TO, Povolotskaya IS, Eroshkin
FM, Zaraisky AG, Mishin AS, Dolgov SV, Mitiouchkina TY, Kopantzev EP, Waldenmaier
HE, Oliveira AG, Oba Y, Barsova E, Bogdanova EA, Gabaldón T, Stevani CV, Lukyanov
S, Smirnov IV, Gitelson JI, Kondrashov F, Yampolsky IV. 2018. Genetically encodable
bioluminescent system from fungi. Proceedings of the National Academy of Sciences
of the United States of America. 115(50), 12728–12732.
mla: Kotlobay, Alexey A., et al. “Genetically Encodable Bioluminescent System from
Fungi.” Proceedings of the National Academy of Sciences of the United States
of America, vol. 115, no. 50, National Academy of Sciences, 2018, pp. 12728–32,
doi:10.1073/pnas.1803615115.
short: A.A. Kotlobay, K. Sarkisyan, Y.A. Mokrushina, M. Marcet-Houben, E.O. Serebrovskaya,
N.M. Markina, L. Gonzalez Somermeyer, A.Y. Gorokhovatsky, A. Vvedensky, K.V. Purtov,
V.N. Petushkov, N.S. Rodionova, T.V. Chepurnyh, L. Fakhranurova, E.B. Guglya,
R. Ziganshin, A.S. Tsarkova, Z.M. Kaskova, V. Shender, M. Abakumov, T.O. Abakumova,
I.S. Povolotskaya, F.M. Eroshkin, A.G. Zaraisky, A.S. Mishin, S.V. Dolgov, T.Y.
Mitiouchkina, E.P. Kopantzev, H.E. Waldenmaier, A.G. Oliveira, Y. Oba, E. Barsova,
E.A. Bogdanova, T. Gabaldón, C.V. Stevani, S. Lukyanov, I.V. Smirnov, J.I. Gitelson,
F. Kondrashov, I.V. Yampolsky, Proceedings of the National Academy of Sciences
of the United States of America 115 (2018) 12728–12732.
date_created: 2018-12-23T22:59:18Z
date_published: 2018-12-11T00:00:00Z
date_updated: 2023-09-11T14:04:05Z
day: '11'
ddc:
- '580'
department:
- _id: FyKo
doi: 10.1073/pnas.1803615115
external_id:
isi:
- '000452866000068'
file:
- access_level: open_access
checksum: 46b2c12185eb2ddb598f4c7b4bd267bf
content_type: application/pdf
creator: dernst
date_created: 2019-02-05T15:21:40Z
date_updated: 2020-07-14T12:47:11Z
file_id: '5926'
file_name: 2018_PNAS_Kotlobay.pdf
file_size: 1271988
relation: main_file
file_date_updated: 2020-07-14T12:47:11Z
has_accepted_license: '1'
intvolume: ' 115'
isi: 1
issue: '50'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 12728-12732
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
issn:
- '00278424'
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetically encodable bioluminescent system from fungi
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 115
year: '2018'
...
---
_id: '428'
abstract:
- lang: eng
text: The plant hormone gibberellic acid (GA) is a crucial regulator of growth and
development. The main paradigm of GA signaling puts forward transcriptional regulation
via the degradation of DELLA transcriptional repressors. GA has also been shown
to regulate tropic responses by modulation of the plasma membrane incidence of
PIN auxin transporters by an unclear mechanism. Here we uncovered the cellular
and molecular mechanisms by which GA redirects protein trafficking and thus regulates
cell surface functionality. Photoconvertible reporters revealed that GA balances
the protein traffic between the vacuole degradation route and recycling back to
the cell surface. Low GA levels promote vacuolar delivery and degradation of multiple
cargos, including PIN proteins, whereas high GA levels promote their recycling
to the plasma membrane. This GA effect requires components of the retromer complex,
such as Sorting Nexin 1 (SNX1) and its interacting, microtubule (MT)-associated
protein, the Cytoplasmic Linker-Associated Protein (CLASP1). Accordingly, GA regulates
the subcellular distribution of SNX1 and CLASP1, and the intact MT cytoskeleton
is essential for the GA effect on trafficking. This GA cellular action occurs
through DELLA proteins that regulate the MT and retromer presumably via their
interaction partners Prefoldins (PFDs). Our study identified a branching of the
GA signaling pathway at the level of DELLA proteins, which, in parallel to regulating
transcription, also target by a nontranscriptional mechanism the retromer complex
acting at the intersection of the degradation and recycling trafficking routes.
By this mechanism, GA can redirect receptors and transporters to the cell surface,
thus coregulating multiple processes, including PIN-dependent auxin fluxes during
tropic responses.
acknowledgement: "We gratefully acknowledge M. Blázquez (Instituto de Biología Molecular
y Celular de Plantas), M. Fendrych, C. Cuesta Moliner (Institute of Science and
Technology Austria), M. Vanstraelen, M. Nowack (Center for Plant Systems Biology,
Ghent), C. Luschnig (Universitat fur Bodenkultur Wien, Vienna), S. Simon (Central
European Institute of Technology, Brno), C. Sommerville (Carnegie Institution for
Science), and Y. Gu (Penn State University) for making available the materials used
in this study;\r\n...funding from the European Research Council (ERC) under the
European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant Agreement
282300.\r\nCC BY NC ND"
article_processing_charge: No
author:
- first_name: Yuliya
full_name: Salanenka, Yuliya
id: 46DAAE7E-F248-11E8-B48F-1D18A9856A87
last_name: Salanenka
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: Christian
full_name: Löfke, Christian
last_name: Löfke
- first_name: Kaori
full_name: Tabata, Kaori
id: 7DAAEDA4-02D0-11E9-B11A-A5A4D7DFFFD0
last_name: Tabata
- first_name: Satoshi
full_name: Naramoto, Satoshi
last_name: Naramoto
- first_name: Matous
full_name: Glanc, Matous
id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
last_name: Glanc
orcid: 0000-0003-0619-7783
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Salanenka Y, Verstraeten I, Löfke C, et al. Gibberellin DELLA signaling targets
the retromer complex to redirect protein trafficking to the plasma membrane. PNAS.
2018;115(14):3716-3721. doi:10.1073/pnas.1721760115
apa: Salanenka, Y., Verstraeten, I., Löfke, C., Tabata, K., Naramoto, S., Glanc,
M., & Friml, J. (2018). Gibberellin DELLA signaling targets the retromer complex
to redirect protein trafficking to the plasma membrane. PNAS. National
Academy of Sciences. https://doi.org/10.1073/pnas.1721760115
chicago: Salanenka, Yuliya, Inge Verstraeten, Christian Löfke, Kaori Tabata, Satoshi
Naramoto, Matous Glanc, and Jiří Friml. “Gibberellin DELLA Signaling Targets the
Retromer Complex to Redirect Protein Trafficking to the Plasma Membrane.” PNAS.
National Academy of Sciences, 2018. https://doi.org/10.1073/pnas.1721760115.
ieee: Y. Salanenka et al., “Gibberellin DELLA signaling targets the retromer
complex to redirect protein trafficking to the plasma membrane,” PNAS,
vol. 115, no. 14. National Academy of Sciences, pp. 3716–3721, 2018.
ista: Salanenka Y, Verstraeten I, Löfke C, Tabata K, Naramoto S, Glanc M, Friml
J. 2018. Gibberellin DELLA signaling targets the retromer complex to redirect
protein trafficking to the plasma membrane. PNAS. 115(14), 3716–3721.
mla: Salanenka, Yuliya, et al. “Gibberellin DELLA Signaling Targets the Retromer
Complex to Redirect Protein Trafficking to the Plasma Membrane.” PNAS,
vol. 115, no. 14, National Academy of Sciences, 2018, pp. 3716–21, doi:10.1073/pnas.1721760115.
short: Y. Salanenka, I. Verstraeten, C. Löfke, K. Tabata, S. Naramoto, M. Glanc,
J. Friml, PNAS 115 (2018) 3716–3721.
date_created: 2018-12-11T11:46:25Z
date_published: 2018-04-03T00:00:00Z
date_updated: 2023-09-11T14:06:34Z
day: '03'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1073/pnas.1721760115
ec_funded: 1
external_id:
isi:
- '000429012500073'
file:
- access_level: open_access
checksum: 1fcf7223fb8f99559cfa80bd6f24ce44
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T12:30:14Z
date_updated: 2020-07-14T12:46:26Z
file_id: '5700'
file_name: 2018_PNAS_Salanenka.pdf
file_size: 1924101
relation: main_file
file_date_updated: 2020-07-14T12:46:26Z
has_accepted_license: '1'
intvolume: ' 115'
isi: 1
issue: '14'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: ' 3716 - 3721'
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '7395'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Gibberellin DELLA signaling targets the retromer complex to redirect protein
trafficking to the plasma membrane
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 115
year: '2018'
...
---
_id: '62'
abstract:
- lang: eng
text: Imaging is a dominant strategy for data collection in neuroscience, yielding
stacks of images that often scale to gigabytes of data for a single experiment.
Machine learning algorithms from computer vision can serve as a pair of virtual
eyes that tirelessly processes these images, automatically detecting and identifying
microstructures. Unlike learning methods, our Flexible Learning-free Reconstruction
of Imaged Neural volumes (FLoRIN) pipeline exploits structure-specific contextual
clues and requires no training. This approach generalizes across different modalities,
including serially-sectioned scanning electron microscopy (sSEM) of genetically
labeled and contrast enhanced processes, spectral confocal reflectance (SCoRe)
microscopy, and high-energy synchrotron X-ray microtomography (μCT) of large tissue
volumes. We deploy the FLoRIN pipeline on newly published and novel mouse datasets,
demonstrating the high biological fidelity of the pipeline’s reconstructions.
FLoRIN reconstructions are of sufficient quality for preliminary biological study,
for example examining the distribution and morphology of cells or extracting single
axons from functional data. Compared to existing supervised learning methods,
FLoRIN is one to two orders of magnitude faster and produces high-quality reconstructions
that are tolerant to noise and artifacts, as is shown qualitatively and quantitatively.
acknowledgement: 'Equipment was generously donated by the NVIDIA Corporation, and
made available by the National Science Foundation (NSF) through grant #CNS-1629914.
This research used resources of the Argonne Leadership Computing Facility, which
is a DOE Office of Science User Facility supported under Contract DE-AC02-06CH11357.'
article_number: '14247'
article_processing_charge: No
article_type: original
author:
- first_name: Ali
full_name: Shabazi, Ali
last_name: Shabazi
- first_name: Jeffery
full_name: Kinnison, Jeffery
last_name: Kinnison
- first_name: Rafael
full_name: Vescovi, Rafael
last_name: Vescovi
- first_name: Ming
full_name: Du, Ming
last_name: Du
- first_name: Robert
full_name: Hill, Robert
last_name: Hill
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
- first_name: Marc
full_name: Takeno, Marc
last_name: Takeno
- first_name: Hongkui
full_name: Zeng, Hongkui
last_name: Zeng
- first_name: Nuno
full_name: Da Costa, Nuno
last_name: Da Costa
- first_name: Jaime
full_name: Grutzendler, Jaime
last_name: Grutzendler
- first_name: Narayanan
full_name: Kasthuri, Narayanan
last_name: Kasthuri
- first_name: Walter
full_name: Scheirer, Walter
last_name: Scheirer
citation:
ama: Shabazi A, Kinnison J, Vescovi R, et al. Flexible learning-free segmentation
and reconstruction of neural volumes. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-32628-3
apa: Shabazi, A., Kinnison, J., Vescovi, R., Du, M., Hill, R., Jösch, M. A., … Scheirer,
W. (2018). Flexible learning-free segmentation and reconstruction of neural volumes.
Scientific Reports. Nature Publishing Group. https://doi.org/10.1038/s41598-018-32628-3
chicago: Shabazi, Ali, Jeffery Kinnison, Rafael Vescovi, Ming Du, Robert Hill, Maximilian
A Jösch, Marc Takeno, et al. “Flexible Learning-Free Segmentation and Reconstruction
of Neural Volumes.” Scientific Reports. Nature Publishing Group, 2018.
https://doi.org/10.1038/s41598-018-32628-3.
ieee: A. Shabazi et al., “Flexible learning-free segmentation and reconstruction
of neural volumes,” Scientific Reports, vol. 8, no. 1. Nature Publishing
Group, 2018.
ista: Shabazi A, Kinnison J, Vescovi R, Du M, Hill R, Jösch MA, Takeno M, Zeng H,
Da Costa N, Grutzendler J, Kasthuri N, Scheirer W. 2018. Flexible learning-free
segmentation and reconstruction of neural volumes. Scientific Reports. 8(1), 14247.
mla: Shabazi, Ali, et al. “Flexible Learning-Free Segmentation and Reconstruction
of Neural Volumes.” Scientific Reports, vol. 8, no. 1, 14247, Nature Publishing
Group, 2018, doi:10.1038/s41598-018-32628-3.
short: A. Shabazi, J. Kinnison, R. Vescovi, M. Du, R. Hill, M.A. Jösch, M. Takeno,
H. Zeng, N. Da Costa, J. Grutzendler, N. Kasthuri, W. Scheirer, Scientific Reports
8 (2018).
date_created: 2018-12-11T11:44:25Z
date_published: 2018-09-24T00:00:00Z
date_updated: 2023-09-11T14:02:55Z
day: '24'
ddc:
- '570'
department:
- _id: MaJö
doi: 10.1038/s41598-018-32628-3
external_id:
isi:
- '000445336600015'
file:
- access_level: open_access
checksum: 1a14ae0666b82fbaa04bef110e3f6bf2
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T12:22:24Z
date_updated: 2020-07-14T12:47:24Z
file_id: '5699'
file_name: 2018_ScientificReports_Shahbazi.pdf
file_size: 4141645
relation: main_file
file_date_updated: 2020-07-14T12:47:24Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
issue: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '7992'
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: http://doi.org/10.1038/s41598-018-36220-7
scopus_import: '1'
status: public
title: Flexible learning-free segmentation and reconstruction of neural volumes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2018'
...
---
_id: '437'
abstract:
- lang: eng
text: Dendritic cells (DCs) are sentinels of the adaptive immune system that reside
in peripheral organs of mammals. Upon pathogen encounter, they undergo maturation
and up-regulate the chemokine receptor CCR7 that guides them along gradients of
its chemokine ligands CCL19 and 21 to the next draining lymph node. There, DCs
present peripherally acquired antigen to naïve T cells, thereby triggering adaptive
immunity.
acknowledged_ssus:
- _id: SSU
acknowledgement: "This work was supported by grants of the European Research Council
(ERC CoG 724373) and the Austrian Science Fund (FWF) to M.S. We thank the scientific
support units at IST Austria for excellent technical support.\r\nWe thank the scientific
\ support units at IST Austria for excellent technical support. "
article_processing_charge: Yes (via OA deal)
author:
- first_name: Alexander F
full_name: Leithner, Alexander F
id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
last_name: Leithner
orcid: 0000-0002-1073-744X
- first_name: Jörg
full_name: Renkawitz, Jörg
id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
last_name: Renkawitz
orcid: 0000-0003-2856-3369
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Hans
full_name: Haecker, Hans
last_name: Haecker
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Leithner AF, Renkawitz J, de Vries I, Hauschild R, Haecker H, Sixt MK. Fast
and efficient genetic engineering of hematopoietic precursor cells for the study
of dendritic cell migration. European Journal of Immunology. 2018;48(6):1074-1077.
doi:10.1002/eji.201747358
apa: Leithner, A. F., Renkawitz, J., de Vries, I., Hauschild, R., Haecker, H., &
Sixt, M. K. (2018). Fast and efficient genetic engineering of hematopoietic precursor
cells for the study of dendritic cell migration. European Journal of Immunology.
Wiley-Blackwell. https://doi.org/10.1002/eji.201747358
chicago: Leithner, Alexander F, Jörg Renkawitz, Ingrid de Vries, Robert Hauschild,
Hans Haecker, and Michael K Sixt. “Fast and Efficient Genetic Engineering of Hematopoietic
Precursor Cells for the Study of Dendritic Cell Migration.” European Journal
of Immunology. Wiley-Blackwell, 2018. https://doi.org/10.1002/eji.201747358.
ieee: A. F. Leithner, J. Renkawitz, I. de Vries, R. Hauschild, H. Haecker, and M.
K. Sixt, “Fast and efficient genetic engineering of hematopoietic precursor cells
for the study of dendritic cell migration,” European Journal of Immunology,
vol. 48, no. 6. Wiley-Blackwell, pp. 1074–1077, 2018.
ista: Leithner AF, Renkawitz J, de Vries I, Hauschild R, Haecker H, Sixt MK. 2018.
Fast and efficient genetic engineering of hematopoietic precursor cells for the
study of dendritic cell migration. European Journal of Immunology. 48(6), 1074–1077.
mla: Leithner, Alexander F., et al. “Fast and Efficient Genetic Engineering of Hematopoietic
Precursor Cells for the Study of Dendritic Cell Migration.” European Journal
of Immunology, vol. 48, no. 6, Wiley-Blackwell, 2018, pp. 1074–77, doi:10.1002/eji.201747358.
short: A.F. Leithner, J. Renkawitz, I. de Vries, R. Hauschild, H. Haecker, M.K.
Sixt, European Journal of Immunology 48 (2018) 1074–1077.
date_created: 2018-12-11T11:46:28Z
date_published: 2018-02-13T00:00:00Z
date_updated: 2023-09-11T14:01:18Z
day: '13'
ddc:
- '570'
department:
- _id: MiSi
- _id: Bio
doi: 10.1002/eji.201747358
ec_funded: 1
external_id:
isi:
- '000434963700016'
file:
- access_level: open_access
checksum: 9d5b74cd016505aeb9a4c2d33bbedaeb
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:56Z
date_updated: 2020-07-14T12:46:27Z
file_id: '5044'
file_name: IST-2018-1067-v1+2_Leithner_et_al-2018-European_Journal_of_Immunology.pdf
file_size: 590106
relation: main_file
file_date_updated: 2020-07-14T12:46:27Z
has_accepted_license: '1'
intvolume: ' 48'
isi: 1
issue: '6'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 1074 - 1077
project:
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '724373'
name: Cellular navigation along spatial gradients
publication: European Journal of Immunology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '7386'
pubrep_id: '1067'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast and efficient genetic engineering of hematopoietic precursor cells for
the study of dendritic cell migration
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 48
year: '2018'
...
---
_id: '617'
abstract:
- lang: eng
text: Insects are exposed to a variety of potential pathogens in their environment,
many of which can severely impact fitness and health. Consequently, hosts have
evolved resistance and tolerance strategies to suppress or cope with infections.
Hosts utilizing resistance improve fitness by clearing or reducing pathogen loads,
and hosts utilizing tolerance reduce harmful fitness effects per pathogen load.
To understand variation in, and selective pressures on, resistance and tolerance,
we asked to what degree they are shaped by host genetic background, whether plasticity
in these responses depends upon dietary environment, and whether there are interactions
between these two factors. Females from ten wild-type Drosophila melanogaster
genotypes were kept on high- or low-protein (yeast) diets and infected with one
of two opportunistic bacterial pathogens, Lactococcus lactis or Pseudomonas entomophila.
We measured host resistance as the inverse of bacterial load in the early infection
phase. The relationship (slope) between fly fecundity and individual-level bacteria
load provided our fecundity tolerance measure. Genotype and dietary yeast determined
host fecundity and strongly affected survival after infection with pathogenic
P. entomophila. There was considerable genetic variation in host resistance, a
commonly found phenomenon resulting from for example varying resistance costs
or frequency-dependent selection. Despite this variation and the reproductive
cost of higher P. entomophila loads, fecundity tolerance did not vary across genotypes.
The absence of genetic variation in tolerance may suggest that at this early infection
stage, fecundity tolerance is fixed or that any evolved tolerance mechanisms are
not expressed under these infection conditions.
acknowledgement: 'We would like to thank Susann Wicke for performing the genome-wide
SNP/indel analyses, as well as Veronica Alves, Kevin Ferro, Momir Futo, Barbara
Hasert, Dafne Maximo, Nora Schulz, Marlene Sroka, and Barth Wieczorek for technical
help. We thank Brian Lazzaro for the L. lactis strain and Bruno Lemaitre for the
Pseudomonas entomophila strain. We would like to thank two anonymous reviewers for
their helpful comments. We are grateful to the Deutsche Forschungsgemeinschaft (DFG)
priority programme 1399 ‘Host parasite coevolution’ for funding this project (AR
872/1-1). '
article_processing_charge: No
article_type: original
author:
- first_name: Megan
full_name: Kutzer, Megan
id: 29D0B332-F248-11E8-B48F-1D18A9856A87
last_name: Kutzer
orcid: 0000-0002-8696-6978
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
- first_name: Sophie
full_name: Armitage, Sophie
last_name: Armitage
citation:
ama: Kutzer M, Kurtz J, Armitage S. Genotype and diet affect resistance, survival,
and fecundity but not fecundity tolerance. Journal of Evolutionary Biology.
2018;31(1):159-171. doi:10.1111/jeb.13211
apa: Kutzer, M., Kurtz, J., & Armitage, S. (2018). Genotype and diet affect
resistance, survival, and fecundity but not fecundity tolerance. Journal of
Evolutionary Biology. Wiley. https://doi.org/10.1111/jeb.13211
chicago: Kutzer, Megan, Joachim Kurtz, and Sophie Armitage. “Genotype and Diet Affect
Resistance, Survival, and Fecundity but Not Fecundity Tolerance.” Journal of
Evolutionary Biology. Wiley, 2018. https://doi.org/10.1111/jeb.13211.
ieee: M. Kutzer, J. Kurtz, and S. Armitage, “Genotype and diet affect resistance,
survival, and fecundity but not fecundity tolerance,” Journal of Evolutionary
Biology, vol. 31, no. 1. Wiley, pp. 159–171, 2018.
ista: Kutzer M, Kurtz J, Armitage S. 2018. Genotype and diet affect resistance,
survival, and fecundity but not fecundity tolerance. Journal of Evolutionary Biology.
31(1), 159–171.
mla: Kutzer, Megan, et al. “Genotype and Diet Affect Resistance, Survival, and Fecundity
but Not Fecundity Tolerance.” Journal of Evolutionary Biology, vol. 31,
no. 1, Wiley, 2018, pp. 159–71, doi:10.1111/jeb.13211.
short: M. Kutzer, J. Kurtz, S. Armitage, Journal of Evolutionary Biology 31 (2018)
159–171.
date_created: 2018-12-11T11:47:31Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2023-09-11T14:06:04Z
day: '01'
department:
- _id: SyCr
doi: 10.1111/jeb.13211
external_id:
isi:
- '000419307000014'
pmid:
- '29150962'
intvolume: ' 31'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/jeb.13211
month: '01'
oa: 1
oa_version: Published Version
page: 159 - 171
pmid: 1
publication: Journal of Evolutionary Biology
publication_identifier:
eissn:
- 1420-9101
issn:
- 1010-061X
publication_status: published
publisher: Wiley
publist_id: '7187'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genotype and diet affect resistance, survival, and fecundity but not fecundity
tolerance
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 31
year: '2018'
...
---
_id: '5888'
abstract:
- lang: eng
text: "Despite the remarkable number of scientific breakthroughs of the last 100
years, the treatment of neurodevelopmental\r\ndisorders (e.g., autism spectrum
disorder, intellectual disability) remains a great challenge. Recent advancements
in\r\ngenomics, such as whole-exome or whole-genome sequencing, have enabled scientists
to identify numerous\r\nmutations underlying neurodevelopmental disorders. Given
the few hundred risk genes that have been discovered,\r\nthe etiological variability
and the heterogeneous clinical presentation, the need for genotype — along with
phenotype-\r\nbased diagnosis of individual patients has become a requisite. In
this review we look at recent advancements in\r\ngenomic analysis and their translation
into clinical practice."
article_number: '100'
article_processing_charge: No
author:
- first_name: Dora-Clara
full_name: Tarlungeanu, Dora-Clara
id: 2ABCE612-F248-11E8-B48F-1D18A9856A87
last_name: Tarlungeanu
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: 'Tarlungeanu D-C, Novarino G. Genomics in neurodevelopmental disorders: an
avenue to personalized medicine. Experimental & Molecular Medicine.
2018;50(8). doi:10.1038/s12276-018-0129-7'
apa: 'Tarlungeanu, D.-C., & Novarino, G. (2018). Genomics in neurodevelopmental
disorders: an avenue to personalized medicine. Experimental & Molecular
Medicine. Springer Nature. https://doi.org/10.1038/s12276-018-0129-7'
chicago: 'Tarlungeanu, Dora-Clara, and Gaia Novarino. “Genomics in Neurodevelopmental
Disorders: An Avenue to Personalized Medicine.” Experimental & Molecular
Medicine. Springer Nature, 2018. https://doi.org/10.1038/s12276-018-0129-7.'
ieee: 'D.-C. Tarlungeanu and G. Novarino, “Genomics in neurodevelopmental disorders:
an avenue to personalized medicine,” Experimental & Molecular Medicine,
vol. 50, no. 8. Springer Nature, 2018.'
ista: 'Tarlungeanu D-C, Novarino G. 2018. Genomics in neurodevelopmental disorders:
an avenue to personalized medicine. Experimental & Molecular Medicine. 50(8),
100.'
mla: 'Tarlungeanu, Dora-Clara, and Gaia Novarino. “Genomics in Neurodevelopmental
Disorders: An Avenue to Personalized Medicine.” Experimental & Molecular
Medicine, vol. 50, no. 8, 100, Springer Nature, 2018, doi:10.1038/s12276-018-0129-7.'
short: D.-C. Tarlungeanu, G. Novarino, Experimental & Molecular Medicine 50
(2018).
date_created: 2019-01-27T22:59:11Z
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abstract:
- lang: eng
text: We prove upper and lower bounds on the ground-state energy of the ideal two-dimensional
anyon gas. Our bounds are extensive in the particle number, as for fermions, and
linear in the statistics parameter (Formula presented.). The lower bounds extend
to Lieb–Thirring inequalities for all anyons except bosons.
acknowledgement: Financial support from the Swedish Research Council, grant no. 2013-4734
(D. L.), the European Research Council (ERC) under the European Union’s Horizon
2020 research and innovation programme (grant agreement No 694227, R. S.), and by
the Austrian Science Fund (FWF), project Nr. P 27533-N27 (R. S.), is gratefully
acknowledged.
article_processing_charge: No
author:
- first_name: Douglas
full_name: Lundholm, Douglas
last_name: Lundholm
- first_name: Robert
full_name: Seiringer, Robert
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last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Lundholm D, Seiringer R. Fermionic behavior of ideal anyons. Letters in
Mathematical Physics. 2018;108(11):2523-2541. doi:10.1007/s11005-018-1091-y
apa: Lundholm, D., & Seiringer, R. (2018). Fermionic behavior of ideal anyons.
Letters in Mathematical Physics. Springer. https://doi.org/10.1007/s11005-018-1091-y
chicago: Lundholm, Douglas, and Robert Seiringer. “Fermionic Behavior of Ideal Anyons.”
Letters in Mathematical Physics. Springer, 2018. https://doi.org/10.1007/s11005-018-1091-y.
ieee: D. Lundholm and R. Seiringer, “Fermionic behavior of ideal anyons,” Letters
in Mathematical Physics, vol. 108, no. 11. Springer, pp. 2523–2541, 2018.
ista: Lundholm D, Seiringer R. 2018. Fermionic behavior of ideal anyons. Letters
in Mathematical Physics. 108(11), 2523–2541.
mla: Lundholm, Douglas, and Robert Seiringer. “Fermionic Behavior of Ideal Anyons.”
Letters in Mathematical Physics, vol. 108, no. 11, Springer, 2018, pp.
2523–41, doi:10.1007/s11005-018-1091-y.
short: D. Lundholm, R. Seiringer, Letters in Mathematical Physics 108 (2018) 2523–2541.
date_created: 2018-12-11T11:45:40Z
date_published: 2018-05-11T00:00:00Z
date_updated: 2023-09-11T14:01:57Z
day: '11'
ddc:
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department:
- _id: RoSe
doi: 10.1007/s11005-018-1091-y
ec_funded: 1
external_id:
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oa_version: Published Version
page: 2523-2541
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: 25C878CE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27533_N27
name: Structure of the Excitation Spectrum for Many-Body Quantum Systems
publication: Letters in Mathematical Physics
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publisher: Springer
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title: Fermionic behavior of ideal anyons
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...