[{"oa_version":"Published Version","file":[{"relation":"main_file","file_id":"6845","date_created":"2019-09-02T12:05:18Z","date_updated":"2020-07-14T12:47:42Z","checksum":"160f960844b204057f20896e0e1f8ee7","file_name":"2019_JournalAnatomy_Picco.pdf","access_level":"open_access","file_size":1192994,"content_type":"application/pdf","creator":"dernst"}],"_id":"6844","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","intvolume":" 235","status":"public","ddc":["570"],"title":"A mathematical insight into cell labelling experiments for clonal analysis","issue":"3","abstract":[{"lang":"eng","text":"Studying the progression of the proliferative and differentiative patterns of neural stem cells at the individual cell level is crucial to the understanding of cortex development and how the disruption of such patterns can lead to malformations and neurodevelopmental diseases. However, our understanding of the precise lineage progression programme at single-cell resolution is still incomplete due to the technical variations in lineage- tracing approaches. One of the key challenges involves developing a robust theoretical framework in which we can integrate experimental observations and introduce correction factors to obtain a reliable and representative description of the temporal modulation of proliferation and differentiation. In order to obtain more conclusive insights, we carry out virtual clonal analysis using mathematical modelling and compare our results against experimental data. Using a dataset obtained with Mosaic Analysis with Double Markers, we illustrate how the theoretical description can be exploited to interpret and reconcile the disparity between virtual and experimental results."}],"type":"journal_article","date_published":"2019-09-01T00:00:00Z","citation":{"short":"N. Picco, S. Hippenmeyer, J. Rodarte, C. Streicher, Z. Molnár, P.K. Maini, T.E. Woolley, Journal of Anatomy 235 (2019) 686–696.","mla":"Picco, Noemi, et al. “A Mathematical Insight into Cell Labelling Experiments for Clonal Analysis.” Journal of Anatomy, vol. 235, no. 3, Wiley, 2019, pp. 686–96, doi:10.1111/joa.13001.","chicago":"Picco, Noemi, Simon Hippenmeyer, Julio Rodarte, Carmen Streicher, Zoltán Molnár, Philip K. Maini, and Thomas E. Woolley. “A Mathematical Insight into Cell Labelling Experiments for Clonal Analysis.” Journal of Anatomy. Wiley, 2019. https://doi.org/10.1111/joa.13001.","ama":"Picco N, Hippenmeyer S, Rodarte J, et al. A mathematical insight into cell labelling experiments for clonal analysis. Journal of Anatomy. 2019;235(3):686-696. doi:10.1111/joa.13001","ieee":"N. Picco et al., “A mathematical insight into cell labelling experiments for clonal analysis,” Journal of Anatomy, vol. 235, no. 3. Wiley, pp. 686–696, 2019.","apa":"Picco, N., Hippenmeyer, S., Rodarte, J., Streicher, C., Molnár, Z., Maini, P. K., & Woolley, T. E. (2019). A mathematical insight into cell labelling experiments for clonal analysis. Journal of Anatomy. Wiley. https://doi.org/10.1111/joa.13001","ista":"Picco N, Hippenmeyer S, Rodarte J, Streicher C, Molnár Z, Maini PK, Woolley TE. 2019. A mathematical insight into cell labelling experiments for clonal analysis. Journal of Anatomy. 235(3), 686–696."},"publication":"Journal of Anatomy","page":"686-696","article_type":"original","article_processing_charge":"No","has_accepted_license":"1","day":"01","scopus_import":"1","author":[{"last_name":"Picco","first_name":"Noemi","full_name":"Picco, Noemi"},{"orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","first_name":"Simon","full_name":"Hippenmeyer, Simon"},{"id":"3C70A038-F248-11E8-B48F-1D18A9856A87","first_name":"Julio","last_name":"Rodarte","full_name":"Rodarte, Julio"},{"full_name":"Streicher, Carmen","first_name":"Carmen","last_name":"Streicher","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Molnár","first_name":"Zoltán","full_name":"Molnár, Zoltán"},{"full_name":"Maini, Philip K.","last_name":"Maini","first_name":"Philip K."},{"first_name":"Thomas E.","last_name":"Woolley","full_name":"Woolley, Thomas E."}],"volume":235,"date_created":"2019-09-02T11:57:28Z","date_updated":"2023-08-29T07:19:39Z","year":"2019","publisher":"Wiley","department":[{"_id":"SiHi"}],"publication_status":"published","ec_funded":1,"file_date_updated":"2020-07-14T12:47:42Z","license":"https://creativecommons.org/licenses/by-nc/4.0/","doi":"10.1111/joa.13001","language":[{"iso":"eng"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"external_id":{"isi":["000482426800017"]},"oa":1,"project":[{"_id":"260018B0-B435-11E9-9278-68D0E5697425","grant_number":"725780","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020"}],"quality_controlled":"1","isi":1,"publication_identifier":{"issn":["0021-8782"],"eissn":["1469-7580"]},"month":"09"},{"month":"07","publication_identifier":{"issn":["1527-8204"],"eissn":["1545-293X"]},"doi":"10.1146/annurev-genom-083115-022316","language":[{"iso":"eng"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"pmid":["31283361"],"isi":["000485148400020"]},"isi":1,"quality_controlled":"1","file_date_updated":"2020-07-14T12:47:42Z","license":"https://creativecommons.org/licenses/by/4.0/","author":[{"full_name":"Sella, Guy","last_name":"Sella","first_name":"Guy"},{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","first_name":"Nicholas H"}],"date_created":"2019-09-07T14:28:29Z","date_updated":"2023-08-29T07:49:38Z","volume":20,"year":"2019","pmid":1,"publication_status":"published","department":[{"_id":"NiBa"}],"publisher":"Annual Reviews","day":"05","article_processing_charge":"No","has_accepted_license":"1","scopus_import":"1","date_published":"2019-07-05T00:00:00Z","publication":"Annual Review of Genomics and Human Genetics","citation":{"mla":"Sella, Guy, and Nicholas H. Barton. “Thinking about the Evolution of Complex Traits in the Era of Genome-Wide Association Studies.” Annual Review of Genomics and Human Genetics, vol. 20, Annual Reviews, 2019, pp. 461–93, doi:10.1146/annurev-genom-083115-022316.","short":"G. Sella, N.H. Barton, Annual Review of Genomics and Human Genetics 20 (2019) 461–493.","chicago":"Sella, Guy, and Nicholas H Barton. “Thinking about the Evolution of Complex Traits in the Era of Genome-Wide Association Studies.” Annual Review of Genomics and Human Genetics. Annual Reviews, 2019. https://doi.org/10.1146/annurev-genom-083115-022316.","ama":"Sella G, Barton NH. Thinking about the evolution of complex traits in the era of genome-wide association studies. Annual Review of Genomics and Human Genetics. 2019;20:461-493. doi:10.1146/annurev-genom-083115-022316","ista":"Sella G, Barton NH. 2019. Thinking about the evolution of complex traits in the era of genome-wide association studies. Annual Review of Genomics and Human Genetics. 20, 461–493.","ieee":"G. Sella and N. H. Barton, “Thinking about the evolution of complex traits in the era of genome-wide association studies,” Annual Review of Genomics and Human Genetics, vol. 20. Annual Reviews, pp. 461–493, 2019.","apa":"Sella, G., & Barton, N. H. (2019). Thinking about the evolution of complex traits in the era of genome-wide association studies. Annual Review of Genomics and Human Genetics. Annual Reviews. https://doi.org/10.1146/annurev-genom-083115-022316"},"page":"461-493","abstract":[{"lang":"eng","text":"Many traits of interest are highly heritable and genetically complex, meaning that much of the variation they exhibit arises from differences at numerous loci in the genome. Complex traits and their evolution have been studied for more than a century, but only in the last decade have genome-wide association studies (GWASs) in humans begun to reveal their genetic basis. Here, we bring these threads of research together to ask how findings from GWASs can further our understanding of the processes that give rise to heritable variation in complex traits and of the genetic basis of complex trait evolution in response to changing selection pressures (i.e., of polygenic adaptation). Conversely, we ask how evolutionary thinking helps us to interpret findings from GWASs and informs related efforts of practical importance."}],"type":"journal_article","oa_version":"Published Version","file":[{"access_level":"open_access","file_name":"2019_AnnualReview_Sella.pdf","creator":"dernst","file_size":411491,"content_type":"application/pdf","file_id":"6862","relation":"main_file","checksum":"23d3978cf4739a89ce2c3e779f9305ca","date_created":"2019-09-09T07:22:12Z","date_updated":"2020-07-14T12:47:42Z"}],"_id":"6855","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","ddc":["576"],"status":"public","title":"Thinking about the evolution of complex traits in the era of genome-wide association studies","intvolume":" 20"},{"ec_funded":1,"article_number":"063101","author":[{"first_name":"Krzysztof","last_name":"Mysliwy","id":"316457FC-F248-11E8-B48F-1D18A9856A87","full_name":"Mysliwy, Krzysztof"},{"full_name":"Napiórkowski, Marek","first_name":"Marek","last_name":"Napiórkowski"}],"date_created":"2019-09-01T22:00:59Z","date_updated":"2023-08-29T07:19:13Z","volume":2019,"year":"2019","publication_status":"published","publisher":"IOP Publishing","department":[{"_id":"RoSe"}],"month":"06","publication_identifier":{"eissn":["1742-5468"]},"doi":"10.1088/1742-5468/ab190d","language":[{"iso":"eng"}],"external_id":{"arxiv":["1810.02209"],"isi":["000471650100001"]},"oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1810.02209","open_access":"1"}],"quality_controlled":"1","isi":1,"project":[{"name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"abstract":[{"text":"We discuss thermodynamic properties of harmonically trapped\r\nimperfect quantum gases. The spatial inhomogeneity of these systems imposes\r\na redefinition of the mean-field interparticle potential energy as compared\r\nto the homogeneous case. In our approach, it takes the form a\r\n2N2 ωd, where\r\nN is the number of particles, ω—the harmonic trap frequency, d—system’s\r\ndimensionality, and a is a parameter characterizing the interparticle interaction.\r\nWe provide arguments that this model corresponds to the limiting case of\r\na long-ranged interparticle potential of vanishingly small amplitude. This\r\nconclusion is drawn from a computation similar to the well-known Kac scaling\r\nprocedure, which is presented here in a form adapted to the case of an isotropic\r\nharmonic trap. We show that within the model, the imperfect gas of trapped\r\nrepulsive bosons undergoes the Bose–Einstein condensation provided d > 1.\r\nThe main result of our analysis is that in d = 1 the gas of attractive imperfect\r\nfermions with a = −aF < 0 is thermodynamically equivalent to the gas of\r\nrepulsive bosons with a = aB > 0 provided the parameters aF and aB fulfill\r\nthe relation aB + aF = \u001f. This result supplements similar recent conclusion\r\nabout thermodynamic equivalence of two-dimensional (2D) uniform imperfect\r\nrepulsive Bose and attractive Fermi gases.","lang":"eng"}],"issue":"6","type":"journal_article","oa_version":"Preprint","_id":"6840","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Thermodynamics of inhomogeneous imperfect quantum gases in harmonic traps","status":"public","intvolume":" 2019","day":"13","article_processing_charge":"No","scopus_import":"1","date_published":"2019-06-13T00:00:00Z","publication":"Journal of Statistical Mechanics: Theory and Experiment","citation":{"chicago":"Mysliwy, Krzysztof, and Marek Napiórkowski. “Thermodynamics of Inhomogeneous Imperfect Quantum Gases in Harmonic Traps.” Journal of Statistical Mechanics: Theory and Experiment. IOP Publishing, 2019. https://doi.org/10.1088/1742-5468/ab190d.","mla":"Mysliwy, Krzysztof, and Marek Napiórkowski. “Thermodynamics of Inhomogeneous Imperfect Quantum Gases in Harmonic Traps.” Journal of Statistical Mechanics: Theory and Experiment, vol. 2019, no. 6, 063101, IOP Publishing, 2019, doi:10.1088/1742-5468/ab190d.","short":"K. Mysliwy, M. Napiórkowski, Journal of Statistical Mechanics: Theory and Experiment 2019 (2019).","ista":"Mysliwy K, Napiórkowski M. 2019. Thermodynamics of inhomogeneous imperfect quantum gases in harmonic traps. Journal of Statistical Mechanics: Theory and Experiment. 2019(6), 063101.","ieee":"K. Mysliwy and M. Napiórkowski, “Thermodynamics of inhomogeneous imperfect quantum gases in harmonic traps,” Journal of Statistical Mechanics: Theory and Experiment, vol. 2019, no. 6. IOP Publishing, 2019.","apa":"Mysliwy, K., & Napiórkowski, M. (2019). Thermodynamics of inhomogeneous imperfect quantum gases in harmonic traps. Journal of Statistical Mechanics: Theory and Experiment. IOP Publishing. https://doi.org/10.1088/1742-5468/ab190d","ama":"Mysliwy K, Napiórkowski M. Thermodynamics of inhomogeneous imperfect quantum gases in harmonic traps. Journal of Statistical Mechanics: Theory and Experiment. 2019;2019(6). doi:10.1088/1742-5468/ab190d"}},{"language":[{"iso":"eng"}],"doi":"10.1016/j.jmaa.2019.123435","project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","isi":1,"oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1809.01101","open_access":"1"}],"external_id":{"isi":["000486563900031"],"arxiv":["1809.01101"]},"publication_identifier":{"eissn":["10960813"],"issn":["0022247X"]},"month":"12","volume":480,"date_created":"2019-09-01T22:01:01Z","date_updated":"2023-08-29T07:18:50Z","author":[{"full_name":"Gehér, György Pál","first_name":"György Pál","last_name":"Gehér"},{"full_name":"Titkos, Tamás","last_name":"Titkos","first_name":"Tamás"},{"full_name":"Virosztek, Daniel","orcid":"0000-0003-1109-5511","id":"48DB45DA-F248-11E8-B48F-1D18A9856A87","last_name":"Virosztek","first_name":"Daniel"}],"department":[{"_id":"LaEr"}],"publisher":"Elsevier","publication_status":"published","year":"2019","ec_funded":1,"article_number":"123435","date_published":"2019-12-15T00:00:00Z","article_type":"original","citation":{"mla":"Gehér, György Pál, et al. “On Isometric Embeddings of Wasserstein Spaces – the Discrete Case.” Journal of Mathematical Analysis and Applications, vol. 480, no. 2, 123435, Elsevier, 2019, doi:10.1016/j.jmaa.2019.123435.","short":"G.P. Gehér, T. Titkos, D. Virosztek, Journal of Mathematical Analysis and Applications 480 (2019).","chicago":"Gehér, György Pál, Tamás Titkos, and Daniel Virosztek. “On Isometric Embeddings of Wasserstein Spaces – the Discrete Case.” Journal of Mathematical Analysis and Applications. Elsevier, 2019. https://doi.org/10.1016/j.jmaa.2019.123435.","ama":"Gehér GP, Titkos T, Virosztek D. On isometric embeddings of Wasserstein spaces – the discrete case. Journal of Mathematical Analysis and Applications. 2019;480(2). doi:10.1016/j.jmaa.2019.123435","ista":"Gehér GP, Titkos T, Virosztek D. 2019. On isometric embeddings of Wasserstein spaces – the discrete case. Journal of Mathematical Analysis and Applications. 480(2), 123435.","apa":"Gehér, G. P., Titkos, T., & Virosztek, D. (2019). On isometric embeddings of Wasserstein spaces – the discrete case. Journal of Mathematical Analysis and Applications. Elsevier. https://doi.org/10.1016/j.jmaa.2019.123435","ieee":"G. P. Gehér, T. Titkos, and D. Virosztek, “On isometric embeddings of Wasserstein spaces – the discrete case,” Journal of Mathematical Analysis and Applications, vol. 480, no. 2. Elsevier, 2019."},"publication":"Journal of Mathematical Analysis and Applications","article_processing_charge":"No","day":"15","scopus_import":"1","oa_version":"Preprint","intvolume":" 480","title":"On isometric embeddings of Wasserstein spaces – the discrete case","status":"public","_id":"6843","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"2","abstract":[{"lang":"eng","text":"The aim of this short paper is to offer a complete characterization of all (not necessarily surjective) isometric embeddings of the Wasserstein space Wp(X), where S is a countable discrete metric space and 0
Bulletin Des Sciences Mathematiques, vol. 156, no. 11, 102794, Elsevier, 2019, doi:10.1016/j.bulsci.2019.102794.","short":"K.N. Destagnol, E. Sofos, Bulletin Des Sciences Mathematiques 156 (2019).","chicago":"Destagnol, Kevin N, and Efthymios Sofos. “Rational Points and Prime Values of Polynomials in Moderately Many Variables.” Bulletin Des Sciences Mathematiques. Elsevier, 2019. https://doi.org/10.1016/j.bulsci.2019.102794.","ama":"Destagnol KN, Sofos E. Rational points and prime values of polynomials in moderately many variables. Bulletin des Sciences Mathematiques. 2019;156(11). doi:10.1016/j.bulsci.2019.102794","ista":"Destagnol KN, Sofos E. 2019. Rational points and prime values of polynomials in moderately many variables. Bulletin des Sciences Mathematiques. 156(11), 102794.","ieee":"K. N. Destagnol and E. Sofos, “Rational points and prime values of polynomials in moderately many variables,” Bulletin des Sciences Mathematiques, vol. 156, no. 11. Elsevier, 2019.","apa":"Destagnol, K. N., & Sofos, E. (2019). Rational points and prime values of polynomials in moderately many variables. Bulletin Des Sciences Mathematiques. Elsevier. https://doi.org/10.1016/j.bulsci.2019.102794"},"day":"01","article_processing_charge":"No","scopus_import":"1","oa_version":"Preprint","title":"Rational points and prime values of polynomials in moderately many variables","status":"public","intvolume":" 156","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6835","abstract":[{"text":"We derive the Hasse principle and weak approximation for fibrations of certain varieties in the spirit of work by Colliot-Thélène–Sansuc and Harpaz–Skorobogatov–Wittenberg. Our varieties are defined through polynomials in many variables and part of our work is devoted to establishing Schinzel's hypothesis for polynomials of this kind. This last part is achieved by using arguments behind Birch's well-known result regarding the Hasse principle for complete intersections with the notable difference that we prove our result in 50% fewer variables than in the classical Birch setting. We also study the problem of square-free values of an integer polynomial with 66.6% fewer variables than in the Birch setting.","lang":"eng"}],"issue":"11","type":"journal_article"},{"file":[{"date_updated":"2020-07-14T12:47:42Z","date_created":"2019-09-16T12:42:40Z","checksum":"9cfd986d4108e288cc72276ef047ab0c","relation":"main_file","file_id":"6879","content_type":"application/pdf","file_size":3523795,"creator":"dernst","file_name":"2019_ScientificReports_Fenu.pdf","access_level":"open_access"}],"oa_version":"Published Version","intvolume":" 9","ddc":["570"],"status":"public","title":"A novel magnet-based scratch method for standardisation of wound-healing assays","_id":"6867","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"1","abstract":[{"text":"A novel magnetic scratch method achieves repeatability, reproducibility and geometric control greater than pipette scratch assays and closely approximating the precision of cell exclusion assays while inducing the cell injury inherently necessary for wound healing assays. The magnetic scratch is affordable, easily implemented and standardisable and thus may contribute toward better comparability of data generated in different studies and laboratories.","lang":"eng"}],"type":"journal_article","date_published":"2019-09-02T00:00:00Z","citation":{"apa":"Fenu, M., Bettermann, T., Vogl, C., Darwish-Miranda, N., Schramel, J., Jenner, F., & Ribitsch, I. (2019). A novel magnet-based scratch method for standardisation of wound-healing assays. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-019-48930-7","ieee":"M. Fenu et al., “A novel magnet-based scratch method for standardisation of wound-healing assays,” Scientific Reports, vol. 9, no. 1. Springer Nature, 2019.","ista":"Fenu M, Bettermann T, Vogl C, Darwish-Miranda N, Schramel J, Jenner F, Ribitsch I. 2019. A novel magnet-based scratch method for standardisation of wound-healing assays. Scientific Reports. 9(1), 12625.","ama":"Fenu M, Bettermann T, Vogl C, et al. A novel magnet-based scratch method for standardisation of wound-healing assays. Scientific Reports. 2019;9(1). doi:10.1038/s41598-019-48930-7","chicago":"Fenu, M., T. Bettermann, C. Vogl, Nasser Darwish-Miranda, J. Schramel, F. Jenner, and I. Ribitsch. “A Novel Magnet-Based Scratch Method for Standardisation of Wound-Healing Assays.” Scientific Reports. Springer Nature, 2019. https://doi.org/10.1038/s41598-019-48930-7.","short":"M. Fenu, T. Bettermann, C. Vogl, N. Darwish-Miranda, J. Schramel, F. Jenner, I. Ribitsch, Scientific Reports 9 (2019).","mla":"Fenu, M., et al. “A Novel Magnet-Based Scratch Method for Standardisation of Wound-Healing Assays.” Scientific Reports, vol. 9, no. 1, 12625, Springer Nature, 2019, doi:10.1038/s41598-019-48930-7."},"publication":"Scientific Reports","has_accepted_license":"1","article_processing_charge":"No","day":"02","scopus_import":"1","volume":9,"date_created":"2019-09-15T22:00:42Z","date_updated":"2023-08-29T07:55:15Z","author":[{"first_name":"M.","last_name":"Fenu","full_name":"Fenu, M."},{"full_name":"Bettermann, T.","first_name":"T.","last_name":"Bettermann"},{"full_name":"Vogl, C.","last_name":"Vogl","first_name":"C."},{"orcid":"0000-0002-8821-8236","id":"39CD9926-F248-11E8-B48F-1D18A9856A87","last_name":"Darwish-Miranda","first_name":"Nasser","full_name":"Darwish-Miranda, Nasser"},{"full_name":"Schramel, J.","last_name":"Schramel","first_name":"J."},{"first_name":"F.","last_name":"Jenner","full_name":"Jenner, F."},{"first_name":"I.","last_name":"Ribitsch","full_name":"Ribitsch, I."}],"department":[{"_id":"Bio"}],"publisher":"Springer Nature","publication_status":"published","pmid":1,"year":"2019","file_date_updated":"2020-07-14T12:47:42Z","article_number":"12625","language":[{"iso":"eng"}],"doi":"10.1038/s41598-019-48930-7","isi":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"isi":["000483697800007"],"pmid":["31477739"]},"oa":1,"publication_identifier":{"eissn":["20452322"]},"month":"09"},{"ddc":["570"],"status":"public","title":"Is speciation driven by cycles of mixing and isolation?","intvolume":" 6","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6858","file":[{"access_level":"open_access","file_name":"2019_NSR_Barton.pdf","creator":"dernst","file_size":106463,"content_type":"application/pdf","file_id":"8595","relation":"main_file","success":1,"checksum":"571d60fa21a568607d1fd04e119da88c","date_created":"2020-10-02T09:16:44Z","date_updated":"2020-10-02T09:16:44Z"}],"oa_version":"Published Version","type":"journal_article","issue":"2","article_type":"review","page":"291-292","publication":"National Science Review","citation":{"ama":"Barton NH. Is speciation driven by cycles of mixing and isolation? National Science Review. 2019;6(2):291-292. doi:10.1093/nsr/nwy113","ieee":"N. H. Barton, “Is speciation driven by cycles of mixing and isolation?,” National Science Review, vol. 6, no. 2. Oxford University Press, pp. 291–292, 2019.","apa":"Barton, N. H. (2019). Is speciation driven by cycles of mixing and isolation? National Science Review. Oxford University Press. https://doi.org/10.1093/nsr/nwy113","ista":"Barton NH. 2019. Is speciation driven by cycles of mixing and isolation? National Science Review. 6(2), 291–292.","short":"N.H. Barton, National Science Review 6 (2019) 291–292.","mla":"Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?” National Science Review, vol. 6, no. 2, Oxford University Press, 2019, pp. 291–92, doi:10.1093/nsr/nwy113.","chicago":"Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?” National Science Review. Oxford University Press, 2019. https://doi.org/10.1093/nsr/nwy113."},"date_published":"2019-03-01T00:00:00Z","scopus_import":"1","day":"01","has_accepted_license":"1","article_processing_charge":"No","publication_status":"published","publisher":"Oxford University Press","department":[{"_id":"NiBa"}],"year":"2019","date_updated":"2023-08-29T07:51:09Z","date_created":"2019-09-07T14:43:02Z","volume":6,"author":[{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","first_name":"Nicholas H"}],"file_date_updated":"2020-10-02T09:16:44Z","isi":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"isi":["000467957400025"]},"language":[{"iso":"eng"}],"doi":"10.1093/nsr/nwy113","month":"03","publication_identifier":{"eissn":["2053-714X"],"issn":["2095-5138"]}},{"scopus_import":"1","day":"09","has_accepted_license":"1","article_processing_charge":"No","article_type":"original","publication":"eLife","citation":{"chicago":"Byczkowicz, Niklas, Abdelmoneim Eshra, Jacqueline-Claire Montanaro-Punzengruber, Andrea Trevisiol, Johannes Hirrlinger, Maarten Hp Kole, Ryuichi Shigemoto, and Stefan Hallermann. “HCN Channel-Mediated Neuromodulation Can Control Action Potential Velocity and Fidelity in Central Axons.” ELife. eLife Sciences Publications, 2019. https://doi.org/10.7554/eLife.42766.","mla":"Byczkowicz, Niklas, et al. “HCN Channel-Mediated Neuromodulation Can Control Action Potential Velocity and Fidelity in Central Axons.” ELife, vol. 8, e42766, eLife Sciences Publications, 2019, doi:10.7554/eLife.42766.","short":"N. Byczkowicz, A. Eshra, J.-C. Montanaro-Punzengruber, A. Trevisiol, J. Hirrlinger, M.H. Kole, R. Shigemoto, S. Hallermann, ELife 8 (2019).","ista":"Byczkowicz N, Eshra A, Montanaro-Punzengruber J-C, Trevisiol A, Hirrlinger J, Kole MH, Shigemoto R, Hallermann S. 2019. HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons. eLife. 8, e42766.","ieee":"N. Byczkowicz et al., “HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons,” eLife, vol. 8. eLife Sciences Publications, 2019.","apa":"Byczkowicz, N., Eshra, A., Montanaro-Punzengruber, J.-C., Trevisiol, A., Hirrlinger, J., Kole, M. H., … Hallermann, S. (2019). HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.42766","ama":"Byczkowicz N, Eshra A, Montanaro-Punzengruber J-C, et al. HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons. eLife. 2019;8. doi:10.7554/eLife.42766"},"date_published":"2019-09-09T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels control electrical rhythmicity and excitability in the heart and brain, but the function of HCN channels at the subcellular level in axons remains poorly understood. Here, we show that the action potential conduction velocity in both myelinated and unmyelinated central axons can be bidirectionally modulated by a HCN channel blocker, cyclic adenosine monophosphate (cAMP), and neuromodulators. Recordings from mouse cerebellar mossy fiber boutons show that HCN channels ensure reliable high-frequency firing and are strongly modulated by cAMP (EC50 40 mM; estimated endogenous cAMP concentration 13 mM). In addition, immunogold-electron microscopy revealed HCN2 as the dominating subunit in cerebellar mossy fibers. Computational modeling indicated that HCN2 channels control conduction velocity primarily by altering the resting membrane potential\r\nand are associated with significant metabolic costs. These results suggest that the cAMP-HCN pathway provides neuromodulators with an opportunity to finely tune energy consumption and temporal delays across axons in the brain."}],"ddc":["570"],"status":"public","title":"HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons","intvolume":" 8","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6868","oa_version":"Published Version","file":[{"creator":"dernst","file_size":4008137,"content_type":"application/pdf","file_name":"2019_eLife_Byczkowicz.pdf","access_level":"open_access","date_created":"2019-09-16T13:14:33Z","date_updated":"2020-07-14T12:47:42Z","checksum":"c350b7861ef0fb537cae8a3232aec016","file_id":"6880","relation":"main_file"}],"month":"09","publication_identifier":{"eissn":["2050084X"]},"isi":1,"quality_controlled":"1","external_id":{"isi":["000485663900001"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"language":[{"iso":"eng"}],"doi":"10.7554/eLife.42766","article_number":"e42766","file_date_updated":"2020-07-14T12:47:42Z","publication_status":"published","department":[{"_id":"RySh"}],"publisher":"eLife Sciences Publications","year":"2019","date_updated":"2023-08-30T06:17:06Z","date_created":"2019-09-15T22:00:43Z","volume":8,"author":[{"first_name":"Niklas","last_name":"Byczkowicz","full_name":"Byczkowicz, Niklas"},{"first_name":"Abdelmoneim","last_name":"Eshra","full_name":"Eshra, Abdelmoneim"},{"full_name":"Montanaro-Punzengruber, Jacqueline-Claire","last_name":"Montanaro-Punzengruber","first_name":"Jacqueline-Claire","id":"3786AB44-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Andrea","last_name":"Trevisiol","full_name":"Trevisiol, Andrea"},{"first_name":"Johannes","last_name":"Hirrlinger","full_name":"Hirrlinger, Johannes"},{"first_name":"Maarten Hp","last_name":"Kole","full_name":"Kole, Maarten Hp"},{"full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Stefan","last_name":"Hallermann","full_name":"Hallermann, Stefan"}]},{"volume":146,"date_updated":"2023-08-30T06:19:04Z","date_created":"2019-09-22T22:00:36Z","author":[{"id":"40A4B9E6-F248-11E8-B48F-1D18A9856A87","last_name":"Zhu","first_name":"Qiang","full_name":"Zhu, Qiang"},{"orcid":"0000-0003-4675-6893","id":"460C6802-F248-11E8-B48F-1D18A9856A87","last_name":"Gallemi","first_name":"Marçal","full_name":"Gallemi, Marçal"},{"full_name":"Pospíšil, Jiří","first_name":"Jiří","last_name":"Pospíšil"},{"full_name":"Žádníková, Petra","last_name":"Žádníková","first_name":"Petra"},{"first_name":"Miroslav","last_name":"Strnad","full_name":"Strnad, Miroslav"},{"orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková","first_name":"Eva","full_name":"Benková, Eva"}],"publisher":"The Company of Biologists","department":[{"_id":"EvBe"}],"publication_status":"published","pmid":1,"acknowledgement":"We thank Jiri Friml and Phillip Brewer for inspiring discussion and for help in preparing the manuscript. This research was supported by the Scientific Service Units (SSU) of IST-Austria through resources provided by the Bioimaging Facility\r\n(BIF), the Life Science Facility (LSF).\r\nThis work was supported by grants from the European Research Council (Starting Independent Research Grant ERC-2007-Stg- 207362-HCPO to E.B.). J.P. and M.S. received funds from European Regional Development Fund-Project ‘Centre for Experimental Plant Biology’ (No. CZ.02.1.01/0.0/0.0/16_019/0000738).","year":"2019","ec_funded":1,"article_number":"dev175919","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"doi":"10.1242/dev.175919","project":[{"_id":"253FCA6A-B435-11E9-9278-68D0E5697425","grant_number":"207362","call_identifier":"FP7","name":"Hormonal cross-talk in plant organogenesis"}],"isi":1,"quality_controlled":"1","external_id":{"isi":["000486297400011"],"pmid":["31391194"]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.1242/dev.175919","open_access":"1"}],"publication_identifier":{"eissn":["14779129"]},"month":"09","oa_version":"Published Version","intvolume":" 146","status":"public","title":"Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis","_id":"6897","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"17","abstract":[{"text":"The apical hook is a transiently formed structure that plays a protective role when the germinating seedling penetrates through the soil towards the surface. Crucial for proper bending is the local auxin maxima, which defines the concave (inner) side of the hook curvature. As no sign of asymmetric auxin distribution has been reported in embryonic hypocotyls prior to hook formation, the question of how auxin asymmetry is established in the early phases of seedling germination remains largely unanswered. Here, we analyzed the auxin distribution and expression of PIN auxin efflux carriers from early phases of germination, and show that bending of the root in response to gravity is the crucial initial cue that governs the hypocotyl bending required for apical hook formation. Importantly, polar auxin transport machinery is established gradually after germination starts as a result of tight root-hypocotyl interaction and a proper balance between abscisic acid and gibberellins.","lang":"eng"}],"type":"journal_article","date_published":"2019-09-12T00:00:00Z","article_type":"original","citation":{"chicago":"Zhu, Qiang, Marçal Gallemi, Jiří Pospíšil, Petra Žádníková, Miroslav Strnad, and Eva Benková. “Root Gravity Response Module Guides Differential Growth Determining Both Root Bending and Apical Hook Formation in Arabidopsis.” Development. The Company of Biologists, 2019. https://doi.org/10.1242/dev.175919.","short":"Q. Zhu, M. Gallemi, J. Pospíšil, P. Žádníková, M. Strnad, E. Benková, Development 146 (2019).","mla":"Zhu, Qiang, et al. “Root Gravity Response Module Guides Differential Growth Determining Both Root Bending and Apical Hook Formation in Arabidopsis.” Development, vol. 146, no. 17, dev175919, The Company of Biologists, 2019, doi:10.1242/dev.175919.","ieee":"Q. Zhu, M. Gallemi, J. Pospíšil, P. Žádníková, M. Strnad, and E. Benková, “Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis,” Development, vol. 146, no. 17. The Company of Biologists, 2019.","apa":"Zhu, Q., Gallemi, M., Pospíšil, J., Žádníková, P., Strnad, M., & Benková, E. (2019). Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis. Development. The Company of Biologists. https://doi.org/10.1242/dev.175919","ista":"Zhu Q, Gallemi M, Pospíšil J, Žádníková P, Strnad M, Benková E. 2019. Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis. Development. 146(17), dev175919.","ama":"Zhu Q, Gallemi M, Pospíšil J, Žádníková P, Strnad M, Benková E. Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis. Development. 2019;146(17). doi:10.1242/dev.175919"},"publication":"Development","article_processing_charge":"No","day":"12","scopus_import":"1"},{"main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.9808772.v1","open_access":"1"}],"citation":{"ama":"Sigalova O, Chaplin A, Bochkareva O, et al. Additional file 11 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. 2019. doi:10.6084/m9.figshare.9808772.v1","ista":"Sigalova O, Chaplin A, Bochkareva O, Shelyakin P, Filaretov V, Akkuratov E, Burskaia V, Gelfand MS. 2019. Additional file 11 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction, Springer Nature, 10.6084/m9.figshare.9808772.v1.","ieee":"O. Sigalova et al., “Additional file 11 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction.” Springer Nature, 2019.","apa":"Sigalova, O., Chaplin, A., Bochkareva, O., Shelyakin, P., Filaretov, V., Akkuratov, E., … Gelfand, M. S. (2019). Additional file 11 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. Springer Nature. https://doi.org/10.6084/m9.figshare.9808772.v1","mla":"Sigalova, Olga, et al. Additional File 11 of Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction. Springer Nature, 2019, doi:10.6084/m9.figshare.9808772.v1.","short":"O. Sigalova, A. Chaplin, O. Bochkareva, P. Shelyakin, V. Filaretov, E. Akkuratov, V. Burskaia, M.S. Gelfand, (2019).","chicago":"Sigalova, Olga, Andrei Chaplin, Olga Bochkareva, Pavel Shelyakin, Vsevolod Filaretov, Evgeny Akkuratov, Valentina Burskaia, and Mikhail S. Gelfand. “Additional File 11 of Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction.” Springer Nature, 2019. https://doi.org/10.6084/m9.figshare.9808772.v1."},"oa":1,"date_published":"2019-09-12T00:00:00Z","doi":"10.6084/m9.figshare.9808772.v1","day":"12","month":"09","article_processing_charge":"No","_id":"9731","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","year":"2019","status":"public","title":"Additional file 11 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction","department":[{"_id":"FyKo"}],"publisher":"Springer Nature","author":[{"last_name":"Sigalova","first_name":"Olga","full_name":"Sigalova, Olga"},{"last_name":"Chaplin","first_name":"Andrei","full_name":"Chaplin, Andrei"},{"last_name":"Bochkareva","first_name":"Olga","orcid":"0000-0003-1006-6639","id":"C4558D3C-6102-11E9-A62E-F418E6697425","full_name":"Bochkareva, Olga"},{"last_name":"Shelyakin","first_name":"Pavel","full_name":"Shelyakin, Pavel"},{"first_name":"Vsevolod","last_name":"Filaretov","full_name":"Filaretov, Vsevolod"},{"full_name":"Akkuratov, Evgeny","first_name":"Evgeny","last_name":"Akkuratov"},{"full_name":"Burskaia, Valentina","last_name":"Burskaia","first_name":"Valentina"},{"first_name":"Mikhail S.","last_name":"Gelfand","full_name":"Gelfand, Mikhail S."}],"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"6898"}]},"date_updated":"2023-08-30T06:20:21Z","date_created":"2021-07-27T14:09:11Z","oa_version":"Published Version","type":"research_data_reference","abstract":[{"lang":"eng","text":"OGs with putative pseudogenes by the number of affected genomes in different chlamydial species. Frameshift and nonsense mutations located less than 60 bp upstreamof the gene end or present in a single genome from the corresponding OG were excluded. (CSV 31 kb)"}]}]