[{"file":[{"file_size":1941355,"content_type":"application/pdf","creator":"rcubero","access_level":"open_access","file_name":"10827_2020_740_MOESM1_ESM.pdf","checksum":"036e9451d6cd0c190ad25791bf82393b","date_updated":"2020-07-14T12:47:56Z","date_created":"2020-01-28T09:31:09Z","relation":"supplementary_material","file_id":"7380"},{"creator":"rcubero","file_size":3257880,"content_type":"application/pdf","file_name":"Cubero2020_Article_MultiscaleRelevanceAndInformat.pdf","access_level":"open_access","date_updated":"2020-07-14T12:47:56Z","date_created":"2020-01-28T09:31:09Z","checksum":"4dd8b1fd4b54486f79d82ac7b2a412b2","file_id":"7381","relation":"main_file"}],"oa_version":"Published Version","intvolume":" 48","title":"Multiscale relevance and informative encoding in neuronal spike trains","ddc":["004","519","570"],"status":"public","_id":"7369","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"text":"Neuronal responses to complex stimuli and tasks can encompass a wide range of time scales. Understanding these responses requires measures that characterize how the information on these response patterns are represented across multiple temporal resolutions. In this paper we propose a metric – which we call multiscale relevance (MSR) – to capture the dynamical variability of the activity of single neurons across different time scales. The MSR is a non-parametric, fully featureless indicator in that it uses only the time stamps of the firing activity without resorting to any a priori covariate or invoking any specific structure in the tuning curve for neural activity. When applied to neural data from the mEC and from the ADn and PoS regions of freely-behaving rodents, we found that neurons having low MSR tend to have low mutual information and low firing sparsity across the correlates that are believed to be encoded by the region of the brain where the recordings were made. In addition, neurons with high MSR contain significant information on spatial navigation and allow to decode spatial position or head direction as efficiently as those neurons whose firing activity has high mutual information with the covariate to be decoded and significantly better than the set of neurons with high local variations in their interspike intervals. Given these results, we propose that the MSR can be used as a measure to rank and select neurons for their information content without the need to appeal to any a priori covariate.","lang":"eng"}],"type":"journal_article","date_published":"2020-02-01T00:00:00Z","page":"85-102","article_type":"original","citation":{"short":"R.J. Cubero, M. Marsili, Y. Roudi, Journal of Computational Neuroscience 48 (2020) 85–102.","mla":"Cubero, Ryan J., et al. “Multiscale Relevance and Informative Encoding in Neuronal Spike Trains.” Journal of Computational Neuroscience, vol. 48, Springer Nature, 2020, pp. 85–102, doi:10.1007/s10827-020-00740-x.","chicago":"Cubero, Ryan J, Matteo Marsili, and Yasser Roudi. “Multiscale Relevance and Informative Encoding in Neuronal Spike Trains.” Journal of Computational Neuroscience. Springer Nature, 2020. https://doi.org/10.1007/s10827-020-00740-x.","ama":"Cubero RJ, Marsili M, Roudi Y. Multiscale relevance and informative encoding in neuronal spike trains. Journal of Computational Neuroscience. 2020;48:85-102. doi:10.1007/s10827-020-00740-x","apa":"Cubero, R. J., Marsili, M., & Roudi, Y. (2020). Multiscale relevance and informative encoding in neuronal spike trains. Journal of Computational Neuroscience. Springer Nature. https://doi.org/10.1007/s10827-020-00740-x","ieee":"R. J. Cubero, M. Marsili, and Y. Roudi, “Multiscale relevance and informative encoding in neuronal spike trains,” Journal of Computational Neuroscience, vol. 48. Springer Nature, pp. 85–102, 2020.","ista":"Cubero RJ, Marsili M, Roudi Y. 2020. Multiscale relevance and informative encoding in neuronal spike trains. Journal of Computational Neuroscience. 48, 85–102."},"publication":"Journal of Computational Neuroscience","article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","day":"01","keyword":["Time series analysis","Multiple time scale analysis","Spike train data","Information theory","Bayesian decoding"],"scopus_import":"1","volume":48,"date_created":"2020-01-28T10:34:00Z","date_updated":"2023-08-17T14:35:22Z","author":[{"last_name":"Cubero","first_name":"Ryan J","orcid":"0000-0003-0002-1867","id":"850B2E12-9CD4-11E9-837F-E719E6697425","full_name":"Cubero, Ryan J"},{"last_name":"Marsili","first_name":"Matteo","full_name":"Marsili, Matteo"},{"first_name":"Yasser","last_name":"Roudi","full_name":"Roudi, Yasser"}],"publisher":"Springer Nature","department":[{"_id":"SaSi"}],"publication_status":"published","year":"2020","acknowledgement":"This research was supported by the Kavli Foundation and the Centre of Excellence scheme of the Research Council of Norway (Centre for Neural Computation). RJC is currently receiving funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411.","ec_funded":1,"file_date_updated":"2020-07-14T12:47:56Z","language":[{"iso":"eng"}],"doi":"10.1007/s10827-020-00740-x","project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"quality_controlled":"1","isi":1,"external_id":{"isi":["000515321800006"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"publication_identifier":{"issn":["0929-5313"],"eissn":["1573-6873"]},"month":"02"},{"abstract":[{"lang":"eng","text":"We present nsCouette, a highly scalable software tool to solve the Navier–Stokes equations for incompressible fluid flow between differentially heated and independently rotating, concentric cylinders. It is based on a pseudospectral spatial discretization and dynamic time-stepping. It is implemented in modern Fortran with a hybrid MPI-OpenMP parallelization scheme and thus designed to compute turbulent flows at high Reynolds and Rayleigh numbers. An additional GPU implementation (C-CUDA) for intermediate problem sizes and a version for pipe flow (nsPipe) are also provided."}],"type":"journal_article","file":[{"creator":"dernst","content_type":"application/pdf","file_size":679707,"access_level":"open_access","file_name":"2020_SoftwareX_Lopez.pdf","checksum":"2af1a1a3cc33557b345145276f221668","date_created":"2020-01-27T07:32:46Z","date_updated":"2020-07-14T12:47:56Z","file_id":"7365","relation":"main_file"}],"oa_version":"Published Version","intvolume":" 11","status":"public","ddc":["000"],"title":"nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow","_id":"7364","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","has_accepted_license":"1","day":"17","scopus_import":"1","date_published":"2020-01-17T00:00:00Z","article_type":"original","citation":{"chicago":"Lopez Alonso, Jose M, Daniel Feldmann, Markus Rampp, Alberto Vela-Martín, Liang Shi, and Marc Avila. “NsCouette – A High-Performance Code for Direct Numerical Simulations of Turbulent Taylor–Couette Flow.” SoftwareX. Elsevier, 2020. https://doi.org/10.1016/j.softx.2019.100395.","mla":"Lopez Alonso, Jose M., et al. “NsCouette – A High-Performance Code for Direct Numerical Simulations of Turbulent Taylor–Couette Flow.” SoftwareX, vol. 11, 100395, Elsevier, 2020, doi:10.1016/j.softx.2019.100395.","short":"J.M. Lopez Alonso, D. Feldmann, M. Rampp, A. Vela-Martín, L. Shi, M. Avila, SoftwareX 11 (2020).","ista":"Lopez Alonso JM, Feldmann D, Rampp M, Vela-Martín A, Shi L, Avila M. 2020. nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow. SoftwareX. 11, 100395.","apa":"Lopez Alonso, J. M., Feldmann, D., Rampp, M., Vela-Martín, A., Shi, L., & Avila, M. (2020). nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow. SoftwareX. Elsevier. https://doi.org/10.1016/j.softx.2019.100395","ieee":"J. M. Lopez Alonso, D. Feldmann, M. Rampp, A. Vela-Martín, L. Shi, and M. Avila, “nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow,” SoftwareX, vol. 11. Elsevier, 2020.","ama":"Lopez Alonso JM, Feldmann D, Rampp M, Vela-Martín A, Shi L, Avila M. nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow. SoftwareX. 2020;11. doi:10.1016/j.softx.2019.100395"},"publication":"SoftwareX","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","file_date_updated":"2020-07-14T12:47:56Z","article_number":"100395","volume":11,"date_created":"2020-01-26T23:00:35Z","date_updated":"2023-08-17T14:29:59Z","author":[{"orcid":"0000-0002-0384-2022","id":"40770848-F248-11E8-B48F-1D18A9856A87","last_name":"Lopez Alonso","first_name":"Jose M","full_name":"Lopez Alonso, Jose M"},{"first_name":"Daniel","last_name":"Feldmann","full_name":"Feldmann, Daniel"},{"full_name":"Rampp, Markus","last_name":"Rampp","first_name":"Markus"},{"full_name":"Vela-Martín, Alberto","last_name":"Vela-Martín","first_name":"Alberto"},{"full_name":"Shi, Liang","id":"374A3F1A-F248-11E8-B48F-1D18A9856A87","last_name":"Shi","first_name":"Liang"},{"full_name":"Avila, Marc","last_name":"Avila","first_name":"Marc"}],"publisher":"Elsevier","department":[{"_id":"BjHo"}],"publication_status":"published","year":"2020","publication_identifier":{"eissn":["23527110"]},"month":"01","language":[{"iso":"eng"}],"doi":"10.1016/j.softx.2019.100395","isi":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"oa":1,"external_id":{"isi":["000552271200011"],"arxiv":["1908.00587"]}},{"article_number":"0623","pmid":1,"acknowledgement":"AK was supported by Grant No. FQXi-RFP-1622 from the FQXi foundation, and Grant No. CHE-1648973 from the U.S.\r\nNational Science Foundation. AK would like to thank the Santa Fe Institute for supporting this research. The authors\r\nthank Jordi Fortuny, Rudolf Hanel, Joshua Garland, and Blai Vidiella for helpful discussions, as well as the anonymous\r\nreviewers for their insightful suggestions. ","year":"2020","publisher":"The Royal Society","department":[{"_id":"EdHa"}],"publication_status":"published","author":[{"last_name":"Kolchinsky","first_name":"Artemy","full_name":"Kolchinsky, Artemy"},{"full_name":"Corominas-Murtra, Bernat","id":"43BE2298-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9806-5643","first_name":"Bernat","last_name":"Corominas-Murtra"}],"volume":17,"date_updated":"2023-08-17T14:31:28Z","date_created":"2020-02-02T23:01:03Z","publication_identifier":{"eissn":["17425662"]},"month":"01","oa":1,"external_id":{"arxiv":["1903.10693"],"isi":["000538369800002"],"pmid":["31964273"]},"main_file_link":[{"url":"https://arxiv.org/abs/1903.10693","open_access":"1"}],"isi":1,"quality_controlled":"1","doi":"10.1098/rsif.2019.0623","language":[{"iso":"eng"}],"type":"journal_article","issue":"162","abstract":[{"lang":"eng","text":"In many real-world systems, information can be transmitted in two qualitatively different ways: by copying or by transformation. Copying occurs when messages are transmitted without modification, e.g. when an offspring receives an unaltered copy of a gene from its parent. Transformation occurs when messages are modified systematically during transmission, e.g. when mutational biases occur during genetic replication. Standard information-theoretic measures do not distinguish these two modes of information transfer, although they may reflect different mechanisms and have different functional consequences. Starting from a few simple axioms, we derive a decomposition of mutual information into the information transmitted by copying versus the information transmitted by transformation. We begin with a decomposition that applies when the source and destination of the channel have the same set of messages and a notion of message identity exists. We then generalize our decomposition to other kinds of channels, which can involve different source and destination sets and broader notions of similarity. In addition, we show that copy information can be interpreted as the minimal work needed by a physical copying process, which is relevant for understanding the physics of replication. We use the proposed decomposition to explore a model of amino acid substitution rates. Our results apply to any system in which the fidelity of copying, rather than simple predictability, is of critical relevance."}],"_id":"7431","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","intvolume":" 17","status":"public","title":"Decomposing information into copying versus transformation","oa_version":"Preprint","scopus_import":"1","article_processing_charge":"No","day":"29","citation":{"ama":"Kolchinsky A, Corominas-Murtra B. Decomposing information into copying versus transformation. Journal of the Royal Society Interface. 2020;17(162). doi:10.1098/rsif.2019.0623","ista":"Kolchinsky A, Corominas-Murtra B. 2020. Decomposing information into copying versus transformation. Journal of the Royal Society Interface. 17(162), 0623.","ieee":"A. Kolchinsky and B. Corominas-Murtra, “Decomposing information into copying versus transformation,” Journal of the Royal Society Interface, vol. 17, no. 162. The Royal Society, 2020.","apa":"Kolchinsky, A., & Corominas-Murtra, B. (2020). Decomposing information into copying versus transformation. Journal of the Royal Society Interface. The Royal Society. https://doi.org/10.1098/rsif.2019.0623","mla":"Kolchinsky, Artemy, and Bernat Corominas-Murtra. “Decomposing Information into Copying versus Transformation.” Journal of the Royal Society Interface, vol. 17, no. 162, 0623, The Royal Society, 2020, doi:10.1098/rsif.2019.0623.","short":"A. Kolchinsky, B. Corominas-Murtra, Journal of the Royal Society Interface 17 (2020).","chicago":"Kolchinsky, Artemy, and Bernat Corominas-Murtra. “Decomposing Information into Copying versus Transformation.” Journal of the Royal Society Interface. The Royal Society, 2020. https://doi.org/10.1098/rsif.2019.0623."},"publication":"Journal of the Royal Society Interface","article_type":"original","date_published":"2020-01-29T00:00:00Z"},{"oa_version":"Preprint","status":"public","ddc":["515"],"title":"Isometric study of Wasserstein spaces - the real line","intvolume":" 373","_id":"7389","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"lang":"eng","text":"Recently Kloeckner described the structure of the isometry group of the quadratic Wasserstein space W_2(R^n). It turned out that the case of the real line is exceptional in the sense that there exists an exotic isometry flow. Following this line of investigation, we compute Isom(W_p(R)), the isometry group of the Wasserstein space\r\nW_p(R) for all p \\in [1,\\infty) \\setminus {2}. We show that W_2(R) is also exceptional regarding the\r\nparameter p: W_p(R) is isometrically rigid if and only if p is not equal to 2. Regarding the underlying\r\nspace, we prove that the exceptionality of p = 2 disappears if we replace R by the compact\r\ninterval [0,1]. Surprisingly, in that case, W_p([0,1]) is isometrically rigid if and only if\r\np is not equal to 1. Moreover, W_1([0,1]) admits isometries that split mass, and Isom(W_1([0,1]))\r\ncannot be embedded into Isom(W_1(R))."}],"issue":"8","type":"journal_article","date_published":"2020-08-01T00:00:00Z","article_type":"original","page":"5855-5883","publication":"Transactions of the American Mathematical Society","citation":{"ama":"Geher GP, Titkos T, Virosztek D. Isometric study of Wasserstein spaces - the real line. Transactions of the American Mathematical Society. 2020;373(8):5855-5883. doi:10.1090/tran/8113","ieee":"G. P. Geher, T. Titkos, and D. Virosztek, “Isometric study of Wasserstein spaces - the real line,” Transactions of the American Mathematical Society, vol. 373, no. 8. American Mathematical Society, pp. 5855–5883, 2020.","apa":"Geher, G. P., Titkos, T., & Virosztek, D. (2020). Isometric study of Wasserstein spaces - the real line. Transactions of the American Mathematical Society. American Mathematical Society. https://doi.org/10.1090/tran/8113","ista":"Geher GP, Titkos T, Virosztek D. 2020. Isometric study of Wasserstein spaces - the real line. Transactions of the American Mathematical Society. 373(8), 5855–5883.","short":"G.P. Geher, T. Titkos, D. Virosztek, Transactions of the American Mathematical Society 373 (2020) 5855–5883.","mla":"Geher, Gyorgy Pal, et al. “Isometric Study of Wasserstein Spaces - the Real Line.” Transactions of the American Mathematical Society, vol. 373, no. 8, American Mathematical Society, 2020, pp. 5855–83, doi:10.1090/tran/8113.","chicago":"Geher, Gyorgy Pal, Tamas Titkos, and Daniel Virosztek. “Isometric Study of Wasserstein Spaces - the Real Line.” Transactions of the American Mathematical Society. American Mathematical Society, 2020. https://doi.org/10.1090/tran/8113."},"day":"01","article_processing_charge":"No","keyword":["Wasserstein space","isometric embeddings","isometric rigidity","exotic isometry flow"],"date_updated":"2023-08-17T14:31:03Z","date_created":"2020-01-29T10:20:46Z","volume":373,"author":[{"full_name":"Geher, Gyorgy Pal","first_name":"Gyorgy Pal","last_name":"Geher"},{"full_name":"Titkos, Tamas","first_name":"Tamas","last_name":"Titkos"},{"last_name":"Virosztek","first_name":"Daniel","orcid":"0000-0003-1109-5511","id":"48DB45DA-F248-11E8-B48F-1D18A9856A87","full_name":"Virosztek, Daniel"}],"publication_status":"published","department":[{"_id":"LaEr"}],"publisher":"American Mathematical Society","year":"2020","ec_funded":1,"language":[{"iso":"eng"}],"doi":"10.1090/tran/8113","isi":1,"quality_controlled":"1","project":[{"name":"Geometric study of Wasserstein spaces and free probability","call_identifier":"H2020","_id":"26A455A6-B435-11E9-9278-68D0E5697425","grant_number":"846294"}],"oa":1,"external_id":{"isi":["000551418100018"],"arxiv":["2002.00859"]},"main_file_link":[{"url":"https://arxiv.org/abs/2002.00859","open_access":"1"}],"month":"08","publication_identifier":{"issn":["00029947"],"eissn":["10886850"]}},{"scopus_import":"1","day":"01","has_accepted_license":"1","article_processing_charge":"No","publication":"ACS Applied Energy Materials","citation":{"mla":"Cadavid, Doris, et al. “Influence of the Ligand Stripping on the Transport Properties of Nanoparticle-Based PbSe Nanomaterials.” ACS Applied Energy Materials, vol. 3, no. 3, American Chemical Society, 2020, pp. 2120–29, doi:10.1021/acsaem.9b02137.","short":"D. Cadavid, S. Ortega, S. Illera, Y. Liu, M. Ibáñez, A. Shavel, Y. Zhang, M. Li, A.M. López, G. Noriega, O.J. Durá, M.A. López De La Torre, J.D. Prades, A. Cabot, ACS Applied Energy Materials 3 (2020) 2120–2129.","chicago":"Cadavid, Doris, Silvia Ortega, Sergio Illera, Yu Liu, Maria Ibáñez, Alexey Shavel, Yu Zhang, et al. “Influence of the Ligand Stripping on the Transport Properties of Nanoparticle-Based PbSe Nanomaterials.” ACS Applied Energy Materials. American Chemical Society, 2020. https://doi.org/10.1021/acsaem.9b02137.","ama":"Cadavid D, Ortega S, Illera S, et al. Influence of the ligand stripping on the transport properties of nanoparticle-based PbSe nanomaterials. ACS Applied Energy Materials. 2020;3(3):2120-2129. doi:10.1021/acsaem.9b02137","ista":"Cadavid D, Ortega S, Illera S, Liu Y, Ibáñez M, Shavel A, Zhang Y, Li M, López AM, Noriega G, Durá OJ, López De La Torre MA, Prades JD, Cabot A. 2020. Influence of the ligand stripping on the transport properties of nanoparticle-based PbSe nanomaterials. ACS Applied Energy Materials. 3(3), 2120–2129.","ieee":"D. Cadavid et al., “Influence of the ligand stripping on the transport properties of nanoparticle-based PbSe nanomaterials,” ACS Applied Energy Materials, vol. 3, no. 3. American Chemical Society, pp. 2120–2129, 2020.","apa":"Cadavid, D., Ortega, S., Illera, S., Liu, Y., Ibáñez, M., Shavel, A., … Cabot, A. (2020). Influence of the ligand stripping on the transport properties of nanoparticle-based PbSe nanomaterials. ACS Applied Energy Materials. American Chemical Society. https://doi.org/10.1021/acsaem.9b02137"},"article_type":"original","page":"2120-2129","date_published":"2020-03-01T00:00:00Z","type":"journal_article","abstract":[{"text":"Nanomaterials produced from the bottom-up assembly of nanocrystals may incorporate ∼1020–1021 cm–3 not fully coordinated surface atoms, i.e., ∼1020–1021 cm–3 potential donor or acceptor states that can strongly affect transport properties. Therefore, to exploit the full potential of nanocrystal building blocks to produce functional nanomaterials and thin films, a proper control of their surface chemistry is required. Here, we analyze how the ligand stripping procedure influences the charge and heat transport properties of sintered PbSe nanomaterials produced from the bottom-up assembly of colloidal PbSe nanocrystals. First, we show that the removal of the native organic ligands by thermal decomposition in an inert atmosphere leaves relatively large amounts of carbon at the crystal interfaces. This carbon blocks crystal growth during consolidation and at the same time hampers charge and heat transport through the final nanomaterial. Second, we demonstrate that, by stripping ligands from the nanocrystal surface before consolidation, nanomaterials with larger crystal domains, lower porosity, and higher charge carrier concentrations are obtained, thus resulting in nanomaterials with higher electrical and thermal conductivities. In addition, the ligand displacement leaves the nanocrystal surface unprotected, facilitating oxidation and chalcogen evaporation. The influence of the ligand displacement on the nanomaterial charge transport properties is rationalized here using a two-band model based on the standard Boltzmann transport equation with the relaxation time approximation. Finally, we present an application of the produced functional nanomaterials by modeling, fabricating, and testing a simple PbSe-based thermoelectric device with a ring geometry.","lang":"eng"}],"issue":"3","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7467","ddc":["540"],"status":"public","title":"Influence of the ligand stripping on the transport properties of nanoparticle-based PbSe nanomaterials","intvolume":" 3","file":[{"access_level":"open_access","file_name":"2020_ACSAppliedEnergyMat_Cadavid.pdf","content_type":"application/pdf","file_size":6423548,"creator":"dernst","relation":"main_file","file_id":"11942","checksum":"f23be731a766a480c77c962c1380315c","success":1,"date_created":"2022-08-23T08:34:17Z","date_updated":"2022-08-23T08:34:17Z"}],"oa_version":"Submitted Version","month":"03","publication_identifier":{"eissn":["2574-0962"]},"oa":1,"external_id":{"isi":["000526598300012"]},"quality_controlled":"1","isi":1,"project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"doi":"10.1021/acsaem.9b02137","language":[{"iso":"eng"}],"file_date_updated":"2022-08-23T08:34:17Z","ec_funded":1,"acknowledgement":"This work was supported by the Spanish Ministerio de Economía y Competitividad through the project SEHTOP (ENE2016-77798-C4-3-R) and the Generalitat de Catalunya through the project 2017SGR1246. D.C. acknowledges support from Universidad Nacional de Colombia. Y.L. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 754411. M.I. acknowledges financial support from IST Austria.","year":"2020","publication_status":"published","publisher":"American Chemical Society","department":[{"_id":"MaIb"}],"author":[{"full_name":"Cadavid, Doris","last_name":"Cadavid","first_name":"Doris"},{"first_name":"Silvia","last_name":"Ortega","full_name":"Ortega, Silvia"},{"first_name":"Sergio","last_name":"Illera","full_name":"Illera, Sergio"},{"full_name":"Liu, Yu","orcid":"0000-0001-7313-6740","id":"2A70014E-F248-11E8-B48F-1D18A9856A87","last_name":"Liu","first_name":"Yu"},{"full_name":"Ibáñez, Maria","orcid":"0000-0001-5013-2843","id":"43C61214-F248-11E8-B48F-1D18A9856A87","last_name":"Ibáñez","first_name":"Maria"},{"first_name":"Alexey","last_name":"Shavel","full_name":"Shavel, Alexey"},{"full_name":"Zhang, Yu","first_name":"Yu","last_name":"Zhang"},{"full_name":"Li, Mengyao","last_name":"Li","first_name":"Mengyao"},{"full_name":"López, Antonio M.","last_name":"López","first_name":"Antonio M."},{"first_name":"Germán","last_name":"Noriega","full_name":"Noriega, Germán"},{"full_name":"Durá, Oscar Juan","first_name":"Oscar Juan","last_name":"Durá"},{"last_name":"López De La Torre","first_name":"M. A.","full_name":"López De La Torre, M. A."},{"first_name":"Joan Daniel","last_name":"Prades","full_name":"Prades, Joan Daniel"},{"full_name":"Cabot, Andreu","first_name":"Andreu","last_name":"Cabot"}],"date_updated":"2023-08-17T14:36:16Z","date_created":"2020-02-09T23:00:52Z","volume":3},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7465","ddc":["580"],"title":"Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization and vascular tissue formation in Arabidopsis","status":"public","intvolume":" 293","oa_version":"Published Version","file":[{"date_updated":"2020-07-14T12:47:59Z","date_created":"2020-02-10T08:59:36Z","checksum":"f7f27c6a8fea985ceb9279be2204461c","file_id":"7471","relation":"main_file","creator":"dernst","content_type":"application/pdf","file_size":3499069,"file_name":"2020_PlantScience_Mazur.pdf","access_level":"open_access"}],"type":"journal_article","abstract":[{"lang":"eng","text":"The flexible development of plants is characterized by a high capacity for post-embryonic organ formation and tissue regeneration, processes, which require tightly regulated intercellular communication and coordinated tissue (re-)polarization. The phytohormone auxin, the main driver for these processes, is able to establish polarized auxin transport channels, which are characterized by the expression and polar, subcellular localization of the PIN1 auxin transport proteins. These channels are demarcating the position of future vascular strands necessary for organ formation and tissue regeneration. Major progress has been made in the last years to understand how PINs can change their polarity in different contexts and thus guide auxin flow through the plant. However, it still remains elusive how auxin mediates the establishment of auxin conducting channels and the formation of vascular tissue and which cellular processes are involved. By the means of sophisticated regeneration experiments combined with local auxin applications in Arabidopsis thaliana inflorescence stems we show that (i) PIN subcellular dynamics, (ii) PIN internalization by clathrin-mediated trafficking and (iii) an intact actin cytoskeleton required for post-endocytic trafficking are indispensable for auxin channel formation, de novo vascular formation and vascular regeneration after wounding. These observations provide novel insights into cellular mechanism of coordinated tissue polarization during auxin canalization."}],"issue":"4","publication":"Plant Science","citation":{"chicago":"Mazur, Ewa, Michelle C Gallei, Maciek Adamowski, Huibin Han, Hélène S. Robert, and Jiří Friml. “Clathrin-Mediated Trafficking and PIN Trafficking Are Required for Auxin Canalization and Vascular Tissue Formation in Arabidopsis.” Plant Science. Elsevier, 2020. https://doi.org/10.1016/j.plantsci.2020.110414.","short":"E. Mazur, M.C. Gallei, M. Adamowski, H. Han, H.S. Robert, J. Friml, Plant Science 293 (2020).","mla":"Mazur, Ewa, et al. “Clathrin-Mediated Trafficking and PIN Trafficking Are Required for Auxin Canalization and Vascular Tissue Formation in Arabidopsis.” Plant Science, vol. 293, no. 4, 110414, Elsevier, 2020, doi:10.1016/j.plantsci.2020.110414.","ieee":"E. Mazur, M. C. Gallei, M. Adamowski, H. Han, H. S. Robert, and J. Friml, “Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization and vascular tissue formation in Arabidopsis,” Plant Science, vol. 293, no. 4. Elsevier, 2020.","apa":"Mazur, E., Gallei, M. C., Adamowski, M., Han, H., Robert, H. S., & Friml, J. (2020). Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization and vascular tissue formation in Arabidopsis. Plant Science. Elsevier. https://doi.org/10.1016/j.plantsci.2020.110414","ista":"Mazur E, Gallei MC, Adamowski M, Han H, Robert HS, Friml J. 2020. Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization and vascular tissue formation in Arabidopsis. Plant Science. 293(4), 110414.","ama":"Mazur E, Gallei MC, Adamowski M, Han H, Robert HS, Friml J. Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization and vascular tissue formation in Arabidopsis. Plant Science. 2020;293(4). doi:10.1016/j.plantsci.2020.110414"},"article_type":"original","date_published":"2020-04-01T00:00:00Z","scopus_import":"1","day":"01","article_processing_charge":"No","has_accepted_license":"1","year":"2020","publication_status":"published","department":[{"_id":"JiFr"}],"publisher":"Elsevier","author":[{"first_name":"Ewa","last_name":"Mazur","full_name":"Mazur, Ewa"},{"full_name":"Gallei, Michelle C","first_name":"Michelle C","last_name":"Gallei","id":"35A03822-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1286-7368"},{"full_name":"Adamowski, Maciek","orcid":"0000-0001-6463-5257","id":"45F536D2-F248-11E8-B48F-1D18A9856A87","last_name":"Adamowski","first_name":"Maciek"},{"full_name":"Han, Huibin","id":"31435098-F248-11E8-B48F-1D18A9856A87","last_name":"Han","first_name":"Huibin"},{"last_name":"Robert","first_name":"Hélène S.","full_name":"Robert, Hélène S."},{"full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","first_name":"Jiří","last_name":"Friml"}],"related_material":{"record":[{"id":"11626","status":"public","relation":"dissertation_contains"}]},"date_updated":"2023-08-17T14:37:32Z","date_created":"2020-02-09T23:00:50Z","volume":293,"article_number":"110414","file_date_updated":"2020-07-14T12:47:59Z","ec_funded":1,"external_id":{"isi":["000520609800009"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"quality_controlled":"1","isi":1,"project":[{"grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants"}],"doi":"10.1016/j.plantsci.2020.110414","language":[{"iso":"eng"}],"month":"04","publication_identifier":{"issn":["01689452"],"eissn":["18732259"]}},{"abstract":[{"lang":"eng","text":"Unpaired ligands are secreted signals that act via a GP130-like receptor, domeless, to activate JAK/STAT signalling in Drosophila. Like many mammalian cytokines, unpaireds can be activated by infection and other stresses and can promote insulin resistance in target tissues. However, the importance of this effect in non-inflammatory physiology is unknown. Here, we identify a requirement for unpaired-JAK signalling as a metabolic regulator in healthy adult Drosophila muscle. Adult muscles show basal JAK-STAT signalling activity in the absence of any immune challenge. Plasmatocytes (Drosophila macrophages) are an important source of this tonic signal. Loss of the dome receptor on adult muscles significantly reduces lifespan and causes local and systemic metabolic pathology. These pathologies result from hyperactivation of AKT and consequent deregulation of metabolism. Thus, we identify a cytokine signal that must be received in muscle to control AKT activity and metabolic homeostasis."}],"type":"journal_article","file":[{"checksum":"3a072be843f416c7a7d532a51dc0addb","date_created":"2020-02-10T08:53:16Z","date_updated":"2020-07-14T12:47:59Z","relation":"main_file","file_id":"7470","content_type":"application/pdf","file_size":4959933,"creator":"dernst","access_level":"open_access","file_name":"2020_eLife_Kierdorf.pdf"}],"oa_version":"Published Version","title":"Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila","status":"public","ddc":["570"],"intvolume":" 9","_id":"7466","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","day":"20","article_processing_charge":"No","has_accepted_license":"1","scopus_import":"1","date_published":"2020-01-20T00:00:00Z","article_type":"original","publication":"eLife","citation":{"ama":"Kierdorf K, Hersperger F, Sharrock J, et al. Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. eLife. 2020;9. doi:10.7554/eLife.51595","ieee":"K. Kierdorf et al., “Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila,” eLife, vol. 9. eLife Sciences Publications, 2020.","apa":"Kierdorf, K., Hersperger, F., Sharrock, J., Vincent, C. M., Ustaoglu, P., Dou, J., … Dionne, M. S. (2020). Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.51595","ista":"Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, György A, Groß O, Siekhaus DE, Dionne MS. 2020. Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. eLife. 9, e51595.","short":"K. Kierdorf, F. Hersperger, J. Sharrock, C.M. Vincent, P. Ustaoglu, J. Dou, A. György, O. Groß, D.E. Siekhaus, M.S. Dionne, ELife 9 (2020).","mla":"Kierdorf, Katrin, et al. “Muscle Function and Homeostasis Require Cytokine Inhibition of AKT Activity in Drosophila.” ELife, vol. 9, e51595, eLife Sciences Publications, 2020, doi:10.7554/eLife.51595.","chicago":"Kierdorf, Katrin, Fabian Hersperger, Jessica Sharrock, Crystal M. Vincent, Pinar Ustaoglu, Jiawen Dou, Attila György, Olaf Groß, Daria E Siekhaus, and Marc S. Dionne. “Muscle Function and Homeostasis Require Cytokine Inhibition of AKT Activity in Drosophila.” ELife. eLife Sciences Publications, 2020. https://doi.org/10.7554/eLife.51595."},"file_date_updated":"2020-07-14T12:47:59Z","article_number":"e51595","date_created":"2020-02-09T23:00:51Z","date_updated":"2023-08-17T14:36:39Z","volume":9,"author":[{"first_name":"Katrin","last_name":"Kierdorf","full_name":"Kierdorf, Katrin"},{"last_name":"Hersperger","first_name":"Fabian","full_name":"Hersperger, Fabian"},{"last_name":"Sharrock","first_name":"Jessica","full_name":"Sharrock, Jessica"},{"full_name":"Vincent, Crystal M.","last_name":"Vincent","first_name":"Crystal M."},{"first_name":"Pinar","last_name":"Ustaoglu","full_name":"Ustaoglu, Pinar"},{"full_name":"Dou, Jiawen","last_name":"Dou","first_name":"Jiawen"},{"first_name":"Attila","last_name":"György","id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1819-198X","full_name":"György, Attila"},{"last_name":"Groß","first_name":"Olaf","full_name":"Groß, Olaf"},{"full_name":"Siekhaus, Daria E","orcid":"0000-0001-8323-8353","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","last_name":"Siekhaus","first_name":"Daria E"},{"full_name":"Dionne, Marc S.","first_name":"Marc S.","last_name":"Dionne"}],"publication_status":"published","department":[{"_id":"DaSi"}],"publisher":"eLife Sciences Publications","year":"2020","month":"01","publication_identifier":{"eissn":["2050084X"]},"language":[{"iso":"eng"}],"doi":"10.7554/eLife.51595","quality_controlled":"1","isi":1,"project":[{"name":"Drosophila TNFa´s Funktion in Immunzellen","call_identifier":"FWF","grant_number":"P29638","_id":"253B6E48-B435-11E9-9278-68D0E5697425"}],"oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"isi":["000512304800001"]}},{"publication_identifier":{"issn":["0896-6273"]},"month":"04","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"M-Shop"}],"doi":"10.1016/j.neuron.2020.01.015","project":[{"call_identifier":"FP7","name":"Inter-and intracellular signalling in schizophrenia","_id":"257BBB4C-B435-11E9-9278-68D0E5697425","grant_number":"607616"}],"isi":1,"quality_controlled":"1","main_file_link":[{"url":"https://doi.org/10.1016/j.neuron.2020.01.015","open_access":"1"}],"oa":1,"external_id":{"isi":["000525319300016"],"pmid":["32032512"]},"ec_funded":1,"volume":106,"date_created":"2020-02-10T15:45:48Z","date_updated":"2023-08-17T14:38:02Z","related_material":{"link":[{"url":"https://ist.ac.at/en/news/this-brain-area-helps-us-decide/","description":"News on IST Homepage","relation":"press_release"}]},"author":[{"last_name":"Käfer","first_name":"Karola","id":"2DAA49AA-F248-11E8-B48F-1D18A9856A87","full_name":"Käfer, Karola"},{"full_name":"Nardin, Michele","orcid":"0000-0001-8849-6570","id":"30BD0376-F248-11E8-B48F-1D18A9856A87","last_name":"Nardin","first_name":"Michele"},{"last_name":"Blahna","first_name":"Karel","id":"3EA859AE-F248-11E8-B48F-1D18A9856A87","full_name":"Blahna, Karel"},{"full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","first_name":"Jozsef L","last_name":"Csicsvari"}],"publisher":"Elsevier","department":[{"_id":"JoCs"}],"publication_status":"published","pmid":1,"acknowledgement":"We thank Todor Asenov and Thomas Menner from the Machine Shop for the drive design and production, Hugo Malagon-Vina for assistance in maze automatization, Jago Wallenschus for taking the images of the histology, and Federico Stella and Juan Felipe Ramirez-Villegas for comments on an earlier version of the manuscript. This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616 ).","year":"2020","article_processing_charge":"No","day":"08","scopus_import":"1","date_published":"2020-04-08T00:00:00Z","page":"P154-165.e6","article_type":"original","citation":{"ama":"Käfer K, Nardin M, Blahna K, Csicsvari JL. Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. 2020;106(1):P154-165.e6. doi:10.1016/j.neuron.2020.01.015","apa":"Käfer, K., Nardin, M., Blahna, K., & Csicsvari, J. L. (2020). Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.01.015","ieee":"K. Käfer, M. Nardin, K. Blahna, and J. L. Csicsvari, “Replay of behavioral sequences in the medial prefrontal cortex during rule switching,” Neuron, vol. 106, no. 1. Elsevier, p. P154–165.e6, 2020.","ista":"Käfer K, Nardin M, Blahna K, Csicsvari JL. 2020. Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. 106(1), P154–165.e6.","short":"K. Käfer, M. Nardin, K. Blahna, J.L. Csicsvari, Neuron 106 (2020) P154–165.e6.","mla":"Käfer, Karola, et al. “Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.” Neuron, vol. 106, no. 1, Elsevier, 2020, p. P154–165.e6, doi:10.1016/j.neuron.2020.01.015.","chicago":"Käfer, Karola, Michele Nardin, Karel Blahna, and Jozsef L Csicsvari. “Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.015."},"publication":"Neuron","issue":"1","abstract":[{"text":"Temporally organized reactivation of experiences during awake immobility periods is thought to underlie cognitive processes like planning and evaluation. While replay of trajectories is well established for the hippocampus, it is unclear whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral experiences in the awake state to support task execution. We simultaneously recorded from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent rule-switching task on a plus maze. We found that mPFC neuronal activity encoded relative positions between the start and goal. During awake immobility periods, the mPFC replayed temporally organized sequences of these generalized positions, resembling entire spatial trajectories. The occurrence of mPFC trajectory replay positively correlated with rule-switching performance. However, hippocampal and mPFC trajectory replay occurred independently, indicating different functions. These results demonstrate that the mPFC can replay ordered activity patterns representing generalized locations and suggest that mPFC replay might have a role in flexible behavior.","lang":"eng"}],"type":"journal_article","oa_version":"Published Version","intvolume":" 106","title":"Replay of behavioral sequences in the medial prefrontal cortex during rule switching","status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7472"},{"year":"2020","publisher":"Elsevier","department":[{"_id":"JaMa"}],"publication_status":"published","author":[{"last_name":"Gerencser","first_name":"Mate","id":"44ECEDF2-F248-11E8-B48F-1D18A9856A87","full_name":"Gerencser, Mate"}],"volume":37,"date_updated":"2023-08-17T14:35:46Z","date_created":"2020-01-29T09:39:41Z","oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1902.07635","open_access":"1"}],"external_id":{"arxiv":["1902.07635"],"isi":["000531049800007"]},"isi":1,"quality_controlled":"1","doi":"10.1016/j.anihpc.2020.01.003","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0294-1449"]},"month":"05","_id":"7388","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","intvolume":" 37","status":"public","title":"Nondivergence form quasilinear heat equations driven by space-time white noise","oa_version":"Preprint","type":"journal_article","issue":"3","abstract":[{"text":"We give a Wong-Zakai type characterisation of the solutions of quasilinear heat equations driven by space-time white noise in 1 + 1 dimensions. In order to show that the renormalisation counterterms are local in the solution, a careful arrangement of a few hundred terms is required. The main tool in this computation is a general ‘integration by parts’ formula that provides a number of linear identities for the renormalisation constants.","lang":"eng"}],"citation":{"mla":"Gerencser, Mate. “Nondivergence Form Quasilinear Heat Equations Driven by Space-Time White Noise.” Annales de l’Institut Henri Poincaré C, Analyse Non Linéaire, vol. 37, no. 3, Elsevier, 2020, pp. 663–82, doi:10.1016/j.anihpc.2020.01.003.","short":"M. Gerencser, Annales de l’Institut Henri Poincaré C, Analyse Non Linéaire 37 (2020) 663–682.","chicago":"Gerencser, Mate. “Nondivergence Form Quasilinear Heat Equations Driven by Space-Time White Noise.” Annales de l’Institut Henri Poincaré C, Analyse Non Linéaire. Elsevier, 2020. https://doi.org/10.1016/j.anihpc.2020.01.003.","ama":"Gerencser M. Nondivergence form quasilinear heat equations driven by space-time white noise. Annales de l’Institut Henri Poincaré C, Analyse non linéaire. 2020;37(3):663-682. doi:10.1016/j.anihpc.2020.01.003","ista":"Gerencser M. 2020. Nondivergence form quasilinear heat equations driven by space-time white noise. Annales de l’Institut Henri Poincaré C, Analyse non linéaire. 37(3), 663–682.","apa":"Gerencser, M. (2020). Nondivergence form quasilinear heat equations driven by space-time white noise. Annales de l’Institut Henri Poincaré C, Analyse Non Linéaire. Elsevier. https://doi.org/10.1016/j.anihpc.2020.01.003","ieee":"M. Gerencser, “Nondivergence form quasilinear heat equations driven by space-time white noise,” Annales de l’Institut Henri Poincaré C, Analyse non linéaire, vol. 37, no. 3. Elsevier, pp. 663–682, 2020."},"publication":"Annales de l'Institut Henri Poincaré C, Analyse non linéaire","page":"663-682","article_type":"original","date_published":"2020-05-01T00:00:00Z","scopus_import":"1","article_processing_charge":"No","day":"01"},{"date_published":"2020-02-10T00:00:00Z","article_type":"original","citation":{"ista":"López De La Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, Sialana FJ, Castilla L, Bae N, Lobo C, Peñalver A, García-Frutos M, Carro D, Enrique V, Paz JC, Mirmira RG, Gutiérrez A, Alonso FJ, Segura JA, Matés JM, Lubec G, Márquez J. 2020. Nuclear translocation of glutaminase GLS2 in human cancer cells associates with proliferation arrest and differentiation. Scientific reports. 10(1), 2259.","ieee":"A. R. López De La Oliva et al., “Nuclear translocation of glutaminase GLS2 in human cancer cells associates with proliferation arrest and differentiation,” Scientific reports, vol. 10, no. 1. Springer Nature, 2020.","apa":"López De La Oliva, A. R., Campos-Sandoval, J. A., Gómez-García, M. C., Cardona, C., Martín-Rufián, M., Sialana, F. J., … Márquez, J. (2020). Nuclear translocation of glutaminase GLS2 in human cancer cells associates with proliferation arrest and differentiation. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-020-58264-4","ama":"López De La Oliva AR, Campos-Sandoval JA, Gómez-García MC, et al. Nuclear translocation of glutaminase GLS2 in human cancer cells associates with proliferation arrest and differentiation. Scientific reports. 2020;10(1). doi:10.1038/s41598-020-58264-4","chicago":"López De La Oliva, Amada R., José A. Campos-Sandoval, María C. Gómez-García, Carolina Cardona, Mercedes Martín-Rufián, Fernando J. Sialana, Laura Castilla, et al. “Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.” Scientific Reports. Springer Nature, 2020. https://doi.org/10.1038/s41598-020-58264-4.","mla":"López De La Oliva, Amada R., et al. “Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.” Scientific Reports, vol. 10, no. 1, 2259, Springer Nature, 2020, doi:10.1038/s41598-020-58264-4.","short":"A.R. López De La Oliva, J.A. Campos-Sandoval, M.C. Gómez-García, C. Cardona, M. Martín-Rufián, F.J. Sialana, L. Castilla, N. Bae, C. Lobo, A. Peñalver, M. García-Frutos, D. Carro, V. Enrique, J.C. Paz, R.G. Mirmira, A. Gutiérrez, F.J. Alonso, J.A. Segura, J.M. Matés, G. Lubec, J. Márquez, Scientific Reports 10 (2020)."},"publication":"Scientific reports","article_processing_charge":"No","has_accepted_license":"1","day":"10","scopus_import":"1","file":[{"creator":"dernst","content_type":"application/pdf","file_size":4703751,"file_name":"2020_ScientificReport_Lopez.pdf","access_level":"open_access","date_created":"2020-02-18T07:43:21Z","date_updated":"2020-07-14T12:47:59Z","checksum":"c780bd87476a9c9e12668ff66de3dc96","file_id":"7495","relation":"main_file"}],"oa_version":"Published Version","intvolume":" 10","status":"public","title":"Nuclear translocation of glutaminase GLS2 in human cancer cells associates with proliferation arrest and differentiation","ddc":["570"],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7487","issue":"1","abstract":[{"text":"Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in cancer metabolic reprogramming. Humans express two types of GA isoforms: GLS and GLS2. GLS isozymes have been consistently related to cell proliferation, but the role of GLS2 in cancer remains poorly understood. GLS2 is repressed in many tumor cells and a better understanding of its function in tumorigenesis may further the development of new therapeutic approaches. We analyzed GLS2 expression in HCC, GBM and neuroblastoma cells, as well as in monkey COS-7 cells. We studied GLS2 expression after induction of differentiation with phorbol ester (PMA) and transduction with the full-length cDNA of GLS2. In parallel, we investigated cell cycle progression and levels of p53, p21 and c-Myc proteins. Using the baculovirus system, human GLS2 protein was overexpressed, purified and analyzed for posttranslational modifications employing a proteomics LC-MS/MS platform. We have demonstrated a dual targeting of GLS2 in human cancer cells. Immunocytochemistry and subcellular fractionation gave consistent results demonstrating nuclear and mitochondrial locations, with the latter being predominant. Nuclear targeting was confirmed in cancer cells overexpressing c-Myc- and GFP-tagged GLS2 proteins. We assessed the subnuclear location finding a widespread distribution of GLS2 in the nucleoplasm without clear overlapping with specific nuclear substructures. GLS2 expression and nuclear accrual notably increased by treatment of SH-SY5Y cells with PMA and it correlated with cell cycle arrest at G2/M, upregulation of tumor suppressor p53 and p21 protein. A similar response was obtained by overexpression of GLS2 in T98G glioma cells, including downregulation of oncogene c-Myc. Furthermore, human GLS2 was identified as being hypusinated by MS analysis, a posttranslational modification which may be relevant for its nuclear targeting and/or function. Our studies provide evidence for a tumor suppressor role of GLS2 in certain types of cancer. The data imply that GLS2 can be regarded as a highly mobile and multilocalizing protein translocated to both mitochondria and nuclei. Upregulation of GLS2 in cancer cells induced an antiproliferative response with cell cycle arrest at the G2/M phase.","lang":"eng"}],"type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1038/s41598-020-58264-4","isi":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"pmid":["32042057"],"isi":["000560694800012"]},"publication_identifier":{"eissn":["20452322"]},"month":"02","volume":10,"date_updated":"2023-08-18T06:35:13Z","date_created":"2020-02-16T23:00:49Z","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41598-020-80651-0"}]},"author":[{"last_name":"López De La Oliva","first_name":"Amada R.","full_name":"López De La Oliva, Amada R."},{"last_name":"Campos-Sandoval","first_name":"José A.","full_name":"Campos-Sandoval, José A."},{"first_name":"María C.","last_name":"Gómez-García","full_name":"Gómez-García, María C."},{"first_name":"Carolina","last_name":"Cardona","full_name":"Cardona, Carolina"},{"full_name":"Martín-Rufián, Mercedes","last_name":"Martín-Rufián","first_name":"Mercedes"},{"first_name":"Fernando J.","last_name":"Sialana","full_name":"Sialana, Fernando J."},{"full_name":"Castilla, Laura","last_name":"Castilla","first_name":"Laura"},{"last_name":"Bae","first_name":"Narkhyun","id":"3A5F7CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Bae, Narkhyun"},{"last_name":"Lobo","first_name":"Carolina","full_name":"Lobo, Carolina"},{"full_name":"Peñalver, Ana","first_name":"Ana","last_name":"Peñalver"},{"last_name":"García-Frutos","first_name":"Marina","full_name":"García-Frutos, Marina"},{"full_name":"Carro, David","last_name":"Carro","first_name":"David"},{"last_name":"Enrique","first_name":"Victoria","full_name":"Enrique, Victoria"},{"first_name":"José C.","last_name":"Paz","full_name":"Paz, José C."},{"full_name":"Mirmira, Raghavendra G.","first_name":"Raghavendra G.","last_name":"Mirmira"},{"full_name":"Gutiérrez, Antonia","last_name":"Gutiérrez","first_name":"Antonia"},{"first_name":"Francisco J.","last_name":"Alonso","full_name":"Alonso, Francisco J."},{"full_name":"Segura, Juan A.","first_name":"Juan A.","last_name":"Segura"},{"first_name":"José M.","last_name":"Matés","full_name":"Matés, José M."},{"full_name":"Lubec, Gert","first_name":"Gert","last_name":"Lubec"},{"full_name":"Márquez, Javier","last_name":"Márquez","first_name":"Javier"}],"publisher":"Springer Nature","department":[{"_id":"CaBe"}],"publication_status":"published","pmid":1,"year":"2020","file_date_updated":"2020-07-14T12:47:59Z","article_number":"2259"}]