---
_id: '6161'
abstract:
- lang: eng
text: 'The tra-1 gene is a terminal regulator of somatic sex in Caenorhabditis elegans:
high tra-1 activity elicits female development, low tra-1 activity elicits male
development. To investigate the function and evolution of tra- 1, we examined
the tra-1 gene from the closely related nematode C. briggsae. Ce-tra-1 and Cb-tra-1
are unusually divergent. Each gene generates two transcripts, but only one of
these is present in both species. This common transcript encodes TRA-1A, which
shows only 44% amino acid identity between the species, a figure much lower than
that for previously compared genes. A Cb-tra-1 transgene rescues many tissues
of tra-1(null) mutants of C. elegans but not the somatic gonad or germ line. This
transgene also causes nongonadal feminization of XO animals, indicating incorrect
sexual regulation. Alignment of Ce-TRA-1A and Cb-TRA-1A defined several conserved
regions likely to be important for tra-1 function. The phenotype differences between
Ce-tra- 1(null) mutants rescued by Cb-tra-1 transgenes and wild-type C. elegans
indicate significant divergence of regulatory regions. These molecular and functional
studies suggest that evolution of sex determination in nematodes is rapid and
genetically complex.'
author:
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: J.
full_name: Hodgkin, J.
last_name: Hodgkin
citation:
ama: 'de Bono M, Hodgkin J. Evolution of sex determination in Caenorhabditis: Unusually
high divergence of tra-1 and its functional consequences. Genetics. 1996;144(2):587-595.'
apa: 'de Bono, M., & Hodgkin, J. (1996). Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences. Genetics.
Genetics Society of America.'
chicago: 'Bono, Mario de, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis:
Unusually High Divergence of Tra-1 and Its Functional Consequences.” Genetics.
Genetics Society of America, 1996.'
ieee: 'M. de Bono and J. Hodgkin, “Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences,” Genetics,
vol. 144, no. 2. Genetics Society of America, pp. 587–595, 1996.'
ista: 'de Bono M, Hodgkin J. 1996. Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences. Genetics.
144(2), 587–595.'
mla: 'de Bono, Mario, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis:
Unusually High Divergence of Tra-1 and Its Functional Consequences.” Genetics,
vol. 144, no. 2, Genetics Society of America, 1996, pp. 587–95.'
short: M. de Bono, J. Hodgkin, Genetics 144 (1996) 587–595.
date_created: 2019-03-21T11:50:37Z
date_published: 1996-10-01T00:00:00Z
date_updated: 2021-01-12T08:06:28Z
day: '01'
extern: '1'
external_id:
pmid:
- '8889522'
intvolume: ' 144'
issue: '2'
keyword:
- amino acid sequence
- article
- caenorhabditis elegans
- evolution
- genetic variability
- nonhuman
- priority journal
- sex determination
- Amino Acid Sequence
- Animals
- Animals
- Genetically Modified
- Base Sequence
- Caenorhabditis
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA
- Helminth
- DNA-Binding Proteins
- Evolution
- Molecular
- Female
- Helminth Proteins
- Membrane Proteins
- Molecular Sequence Data
- Mutagenesis
- RNA
- Messenger
- Sequence Homology
- Amino Acid
- Sex Determination (Analysis)
- Transcription Factors
- Transgenes
- Turner Syndrome
- Animalia
- Caenorhabditis
- Caenorhabditis briggsae
- Caenorhabditis elegans
- Nematoda
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1207552/
month: '10'
oa: 1
oa_version: Published Version
page: 587-595
pmid: 1
publication: Genetics
publication_identifier:
issn:
- '00166731'
publication_status: published
publisher: Genetics Society of America
quality_controlled: '1'
status: public
title: 'Evolution of sex determination in Caenorhabditis: Unusually high divergence
of tra-1 and its functional consequences'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 144
year: '1996'
...