--- _id: '6161' abstract: - lang: eng text: 'The tra-1 gene is a terminal regulator of somatic sex in Caenorhabditis elegans: high tra-1 activity elicits female development, low tra-1 activity elicits male development. To investigate the function and evolution of tra- 1, we examined the tra-1 gene from the closely related nematode C. briggsae. Ce-tra-1 and Cb-tra-1 are unusually divergent. Each gene generates two transcripts, but only one of these is present in both species. This common transcript encodes TRA-1A, which shows only 44% amino acid identity between the species, a figure much lower than that for previously compared genes. A Cb-tra-1 transgene rescues many tissues of tra-1(null) mutants of C. elegans but not the somatic gonad or germ line. This transgene also causes nongonadal feminization of XO animals, indicating incorrect sexual regulation. Alignment of Ce-TRA-1A and Cb-TRA-1A defined several conserved regions likely to be important for tra-1 function. The phenotype differences between Ce-tra- 1(null) mutants rescued by Cb-tra-1 transgenes and wild-type C. elegans indicate significant divergence of regulatory regions. These molecular and functional studies suggest that evolution of sex determination in nematodes is rapid and genetically complex.' author: - first_name: Mario full_name: de Bono, Mario id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87 last_name: de Bono orcid: 0000-0001-8347-0443 - first_name: J. full_name: Hodgkin, J. last_name: Hodgkin citation: ama: 'de Bono M, Hodgkin J. Evolution of sex determination in Caenorhabditis: Unusually high divergence of tra-1 and its functional consequences. Genetics. 1996;144(2):587-595.' apa: 'de Bono, M., & Hodgkin, J. (1996). Evolution of sex determination in Caenorhabditis: Unusually high divergence of tra-1 and its functional consequences. Genetics. Genetics Society of America.' chicago: 'Bono, Mario de, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis: Unusually High Divergence of Tra-1 and Its Functional Consequences.” Genetics. Genetics Society of America, 1996.' ieee: 'M. de Bono and J. Hodgkin, “Evolution of sex determination in Caenorhabditis: Unusually high divergence of tra-1 and its functional consequences,” Genetics, vol. 144, no. 2. Genetics Society of America, pp. 587–595, 1996.' ista: 'de Bono M, Hodgkin J. 1996. Evolution of sex determination in Caenorhabditis: Unusually high divergence of tra-1 and its functional consequences. Genetics. 144(2), 587–595.' mla: 'de Bono, Mario, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis: Unusually High Divergence of Tra-1 and Its Functional Consequences.” Genetics, vol. 144, no. 2, Genetics Society of America, 1996, pp. 587–95.' short: M. de Bono, J. Hodgkin, Genetics 144 (1996) 587–595. date_created: 2019-03-21T11:50:37Z date_published: 1996-10-01T00:00:00Z date_updated: 2021-01-12T08:06:28Z day: '01' extern: '1' external_id: pmid: - '8889522' intvolume: ' 144' issue: '2' keyword: - amino acid sequence - article - caenorhabditis elegans - evolution - genetic variability - nonhuman - priority journal - sex determination - Amino Acid Sequence - Animals - Animals - Genetically Modified - Base Sequence - Caenorhabditis - Caenorhabditis elegans - Caenorhabditis elegans Proteins - DNA - Helminth - DNA-Binding Proteins - Evolution - Molecular - Female - Helminth Proteins - Membrane Proteins - Molecular Sequence Data - Mutagenesis - RNA - Messenger - Sequence Homology - Amino Acid - Sex Determination (Analysis) - Transcription Factors - Transgenes - Turner Syndrome - Animalia - Caenorhabditis - Caenorhabditis briggsae - Caenorhabditis elegans - Nematoda language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1207552/ month: '10' oa: 1 oa_version: Published Version page: 587-595 pmid: 1 publication: Genetics publication_identifier: issn: - '00166731' publication_status: published publisher: Genetics Society of America quality_controlled: '1' status: public title: 'Evolution of sex determination in Caenorhabditis: Unusually high divergence of tra-1 and its functional consequences' type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 144 year: '1996' ...