[{"language":[{"iso":"eng"}],"file":[{"creator":"system","file_size":897050,"date_updated":"2018-12-12T10:15:15Z","file_name":"IST-2017-786-v1+1_ncomms14114.pdf","date_created":"2018-12-12T10:15:15Z","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_id":"5133"}],"publication_status":"published","publication_identifier":{"issn":["20411723"]},"ec_funded":1,"volume":8,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Reconstructing the evolutionary history of metastases is critical for understanding their basic biological principles and has profound clinical implications. Genome-wide sequencing data has enabled modern phylogenomic methods to accurately dissect subclones and their phylogenies from noisy and impure bulk tumour samples at unprecedented depth. However, existing methods are not designed to infer metastatic seeding patterns. Here we develop a tool, called Treeomics, to reconstruct the phylogeny of metastases and map subclones to their anatomic locations. Treeomics infers comprehensive seeding patterns for pancreatic, ovarian, and prostate cancers. Moreover, Treeomics correctly disambiguates true seeding patterns from sequencing artifacts; 7% of variants were misclassified by conventional statistical methods. These artifacts can skew phylogenies by creating illusory tumour heterogeneity among distinct samples. In silico benchmarking on simulated tumour phylogenies across a wide range of sample purities (15–95%) and sequencing depths (25-800 × ) demonstrates the accuracy of Treeomics compared with existing methods."}],"intvolume":" 8","month":"01","scopus_import":"1","ddc":["004","006"],"date_updated":"2023-09-20T11:55:31Z","file_date_updated":"2018-12-12T10:15:15Z","department":[{"_id":"KrCh"}],"_id":"1080","pubrep_id":"786","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","publication":"Nature Communications","day":"31","year":"2017","isi":1,"has_accepted_license":"1","date_created":"2018-12-11T11:50:02Z","doi":"10.1038/ncomms14114","date_published":"2017-01-31T00:00:00Z","oa":1,"publisher":"Nature Publishing Group","quality_controlled":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ista":"Reiter J, Makohon Moore A, Gerold J, Božić I, Chatterjee K, Iacobuzio Donahue C, Vogelstein B, Nowak M. 2017. Reconstructing metastatic seeding patterns of human cancers. Nature Communications. 8, 14114.","chicago":"Reiter, Johannes, Alvin Makohon Moore, Jeffrey Gerold, Ivana Božić, Krishnendu Chatterjee, Christine Iacobuzio Donahue, Bert Vogelstein, and Martin Nowak. “Reconstructing Metastatic Seeding Patterns of Human Cancers.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms14114.","apa":"Reiter, J., Makohon Moore, A., Gerold, J., Božić, I., Chatterjee, K., Iacobuzio Donahue, C., … Nowak, M. (2017). Reconstructing metastatic seeding patterns of human cancers. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms14114","ama":"Reiter J, Makohon Moore A, Gerold J, et al. Reconstructing metastatic seeding patterns of human cancers. Nature Communications. 2017;8. doi:10.1038/ncomms14114","short":"J. Reiter, A. Makohon Moore, J. Gerold, I. Božić, K. Chatterjee, C. Iacobuzio Donahue, B. Vogelstein, M. Nowak, Nature Communications 8 (2017).","ieee":"J. Reiter et al., “Reconstructing metastatic seeding patterns of human cancers,” Nature Communications, vol. 8. Nature Publishing Group, 2017.","mla":"Reiter, Johannes, et al. “Reconstructing Metastatic Seeding Patterns of Human Cancers.” Nature Communications, vol. 8, 14114, Nature Publishing Group, 2017, doi:10.1038/ncomms14114."},"title":"Reconstructing metastatic seeding patterns of human cancers","external_id":{"isi":["000393096600001"]},"article_processing_charge":"No","publist_id":"6301","author":[{"id":"4A918E98-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes","last_name":"Reiter","full_name":"Reiter, Johannes","orcid":"0000-0002-0170-7353"},{"last_name":"Makohon Moore","full_name":"Makohon Moore, Alvin","first_name":"Alvin"},{"first_name":"Jeffrey","full_name":"Gerold, Jeffrey","last_name":"Gerold"},{"last_name":"Božić","full_name":"Božić, Ivana","first_name":"Ivana"},{"full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Iacobuzio Donahue","full_name":"Iacobuzio Donahue, Christine","first_name":"Christine"},{"full_name":"Vogelstein, Bert","last_name":"Vogelstein","first_name":"Bert"},{"last_name":"Nowak","full_name":"Nowak, Martin","first_name":"Martin"}],"article_number":"14114","project":[{"call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425","grant_number":"279307","name":"Quantitative Graph Games: Theory and Applications"},{"grant_number":"P 23499-N23","name":"Modern Graph Algorithmic Techniques in Formal Verification","call_identifier":"FWF","_id":"2584A770-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425","name":"Game Theory","grant_number":"S11407"}]},{"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"chicago":"Wright, Alison, Iulia Darolti, Natasha Bloch, Vicencio Oostra, Benjamin Sandkam, Séverine Buechel, Niclas Kolm, Felix Breden, Beatriz Vicoso, and Judith Mank. “Convergent Recombination Suppression Suggests Role of Sexual Selection in Guppy Sex Chromosome Formation.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms14251.","ista":"Wright A, Darolti I, Bloch N, Oostra V, Sandkam B, Buechel S, Kolm N, Breden F, Vicoso B, Mank J. 2017. Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. Nature Communications. 8, 14251.","mla":"Wright, Alison, et al. “Convergent Recombination Suppression Suggests Role of Sexual Selection in Guppy Sex Chromosome Formation.” Nature Communications, vol. 8, 14251, Nature Publishing Group, 2017, doi:10.1038/ncomms14251.","ieee":"A. Wright et al., “Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation,” Nature Communications, vol. 8. Nature Publishing Group, 2017.","short":"A. Wright, I. Darolti, N. Bloch, V. Oostra, B. Sandkam, S. Buechel, N. Kolm, F. Breden, B. Vicoso, J. Mank, Nature Communications 8 (2017).","apa":"Wright, A., Darolti, I., Bloch, N., Oostra, V., Sandkam, B., Buechel, S., … Mank, J. (2017). Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms14251","ama":"Wright A, Darolti I, Bloch N, et al. Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. Nature Communications. 2017;8. doi:10.1038/ncomms14251"},"title":"Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation","author":[{"last_name":"Wright","full_name":"Wright, Alison","first_name":"Alison"},{"last_name":"Darolti","full_name":"Darolti, Iulia","first_name":"Iulia"},{"full_name":"Bloch, Natasha","last_name":"Bloch","first_name":"Natasha"},{"first_name":"Vicencio","last_name":"Oostra","full_name":"Oostra, Vicencio"},{"first_name":"Benjamin","last_name":"Sandkam","full_name":"Sandkam, Benjamin"},{"first_name":"Séverine","full_name":"Buechel, Séverine","last_name":"Buechel"},{"last_name":"Kolm","full_name":"Kolm, Niclas","first_name":"Niclas"},{"first_name":"Felix","full_name":"Breden, Felix","last_name":"Breden"},{"last_name":"Vicoso","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz"},{"first_name":"Judith","last_name":"Mank","full_name":"Mank, Judith"}],"publist_id":"6292","external_id":{"isi":["000392953700001"]},"article_processing_charge":"No","article_number":"14251","day":"31","publication":"Nature Communications","isi":1,"has_accepted_license":"1","year":"2017","doi":"10.1038/ncomms14251","date_published":"2017-01-31T00:00:00Z","date_created":"2018-12-11T11:50:04Z","publisher":"Nature Publishing Group","quality_controlled":"1","oa":1,"ddc":["570","576"],"date_updated":"2023-09-20T11:48:16Z","file_date_updated":"2018-12-12T10:15:22Z","department":[{"_id":"BeVi"}],"_id":"1085","status":"public","pubrep_id":"791","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"date_created":"2018-12-12T10:15:22Z","file_name":"IST-2017-791-v1+1_ncomms14251.pdf","date_updated":"2018-12-12T10:15:22Z","file_size":955256,"creator":"system","file_id":"5141","content_type":"application/pdf","access_level":"open_access","relation":"main_file"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["20411723"]},"publication_status":"published","volume":8,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Sex chromosomes evolve once recombination is halted between a homologous pair of chromosomes. The dominant model of sex chromosome evolution posits that recombination is suppressed between emerging X and Y chromosomes in order to resolve sexual conflict. Here we test this model using whole genome and transcriptome resequencing data in the guppy, a model for sexual selection with many Y-linked colour traits. We show that although the nascent Y chromosome encompasses nearly half of the linkage group, there has been no perceptible degradation of Y chromosome gene content or activity. Using replicate wild populations with differing levels of sexually antagonistic selection for colour, we also show that sexual selection leads to greater expansion of the non-recombining region and increased Y chromosome divergence. These results provide empirical support for longstanding models of sex chromosome catalysis, and suggest an important role for sexual selection and sexual conflict in genome evolution."}],"month":"01","intvolume":" 8","scopus_import":"1"},{"oa_version":"Published Version","abstract":[{"lang":"eng","text":"In real-world applications, observations are often constrained to a small fraction of a system. Such spatial subsampling can be caused by the inaccessibility or the sheer size of the system, and cannot be overcome by longer sampling. Spatial subsampling can strongly bias inferences about a system’s aggregated properties. To overcome the bias, we derive analytically a subsampling scaling framework that is applicable to different observables, including distributions of neuronal avalanches, of number of people infected during an epidemic outbreak, and of node degrees. We demonstrate how to infer the correct distributions of the underlying full system, how to apply it to distinguish critical from subcritical systems, and how to disentangle subsampling and finite size effects. Lastly, we apply subsampling scaling to neuronal avalanche models and to recordings from developing neural networks. We show that only mature, but not young networks follow power-law scaling, indicating self-organization to criticality during development."}],"month":"05","intvolume":" 8","scopus_import":"1","file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_id":"5122","checksum":"9880212f8c4c53404c7c6fbf9023c53a","file_size":746224,"date_updated":"2020-07-14T12:48:19Z","creator":"system","file_name":"IST-2017-819-v1+1_2017_Levina_SubsamplingScaling.pdf","date_created":"2018-12-12T10:15:05Z"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["20411723"]},"publication_status":"published","volume":8,"ec_funded":1,"_id":"993","status":"public","pubrep_id":"819","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["005","571"],"date_updated":"2023-09-22T09:54:07Z","department":[{"_id":"GaTk"},{"_id":"JoCs"}],"file_date_updated":"2020-07-14T12:48:19Z","quality_controlled":"1","publisher":"Nature Publishing Group","oa":1,"day":"04","publication":"Nature Communications","isi":1,"has_accepted_license":"1","year":"2017","date_published":"2017-05-04T00:00:00Z","doi":"10.1038/ncomms15140","date_created":"2018-12-11T11:49:35Z","article_number":"15140","project":[{"name":"International IST Postdoc Fellowship Programme","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"mla":"Levina (Martius), Anna, and Viola Priesemann. “Subsampling Scaling.” Nature Communications, vol. 8, 15140, Nature Publishing Group, 2017, doi:10.1038/ncomms15140.","ama":"Levina (Martius) A, Priesemann V. Subsampling scaling. Nature Communications. 2017;8. doi:10.1038/ncomms15140","apa":"Levina (Martius), A., & Priesemann, V. (2017). Subsampling scaling. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms15140","short":"A. Levina (Martius), V. Priesemann, Nature Communications 8 (2017).","ieee":"A. Levina (Martius) and V. Priesemann, “Subsampling scaling,” Nature Communications, vol. 8. Nature Publishing Group, 2017.","chicago":"Levina (Martius), Anna, and Viola Priesemann. “Subsampling Scaling.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms15140.","ista":"Levina (Martius) A, Priesemann V. 2017. Subsampling scaling. Nature Communications. 8, 15140."},"title":"Subsampling scaling","author":[{"id":"35AF8020-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","last_name":"Levina (Martius)","full_name":"Levina (Martius), Anna"},{"first_name":"Viola","last_name":"Priesemann","full_name":"Priesemann, Viola"}],"publist_id":"6406","external_id":{"isi":["000400560700001"]},"article_processing_charge":"Yes (in subscription journal)"},{"department":[{"_id":"GaTk"},{"_id":"NiBa"}],"file_date_updated":"2020-07-14T12:48:16Z","date_updated":"2023-09-22T10:00:49Z","ddc":["539","576"],"type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","pubrep_id":"864","_id":"955","related_material":{"record":[{"relation":"dissertation_contains","id":"6071","status":"public"}]},"volume":8,"issue":"1","ec_funded":1,"publication_identifier":{"issn":["20411723"]},"publication_status":"published","file":[{"date_created":"2018-12-12T10:14:14Z","file_name":"IST-2017-864-v1+1_s41467-017-00238-8.pdf","creator":"system","date_updated":"2020-07-14T12:48:16Z","file_size":998157,"checksum":"29a1b5db458048d3bd5c67e0e2a56818","file_id":"5064","access_level":"open_access","relation":"main_file","content_type":"application/pdf"},{"content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_id":"5065","checksum":"7b78401e52a576cf3e6bbf8d0abadc17","date_updated":"2020-07-14T12:48:16Z","file_size":9715993,"creator":"system","date_created":"2018-12-12T10:14:15Z","file_name":"IST-2017-864-v1+2_41467_2017_238_MOESM1_ESM.pdf"}],"language":[{"iso":"eng"}],"scopus_import":"1","month":"08","intvolume":" 8","abstract":[{"text":"Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isolated genetic elements. In contrast, we study the essential process by which regulatory networks grow: the duplication and subsequent specialization of network components. We synthesize a biophysical model of molecular interactions with the evolutionary framework to find the conditions and pathways by which new regulatory functions emerge. We show that specialization of new network components is usually slow, but can be drastically accelerated in the presence of regulatory crosstalk and mutations that promote promiscuous interactions between network components.","lang":"eng"}],"oa_version":"Published Version","author":[{"full_name":"Friedlander, Tamar","last_name":"Friedlander","first_name":"Tamar","id":"36A5845C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Roshan","id":"4456104E-F248-11E8-B48F-1D18A9856A87","full_name":"Prizak, Roshan","last_name":"Prizak"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton"},{"id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","first_name":"Gasper","orcid":"0000-0002-6699-1455","full_name":"Tkacik, Gasper","last_name":"Tkacik"}],"publist_id":"6459","external_id":{"isi":["000407198800005"]},"article_processing_charge":"Yes (in subscription journal)","title":"Evolution of new regulatory functions on biophysically realistic fitness landscapes","citation":{"ista":"Friedlander T, Prizak R, Barton NH, Tkačik G. 2017. Evolution of new regulatory functions on biophysically realistic fitness landscapes. Nature Communications. 8(1), 216.","chicago":"Friedlander, Tamar, Roshan Prizak, Nicholas H Barton, and Gašper Tkačik. “Evolution of New Regulatory Functions on Biophysically Realistic Fitness Landscapes.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/s41467-017-00238-8.","short":"T. Friedlander, R. Prizak, N.H. Barton, G. Tkačik, Nature Communications 8 (2017).","ieee":"T. Friedlander, R. Prizak, N. H. Barton, and G. Tkačik, “Evolution of new regulatory functions on biophysically realistic fitness landscapes,” Nature Communications, vol. 8, no. 1. Nature Publishing Group, 2017.","ama":"Friedlander T, Prizak R, Barton NH, Tkačik G. Evolution of new regulatory functions on biophysically realistic fitness landscapes. Nature Communications. 2017;8(1). doi:10.1038/s41467-017-00238-8","apa":"Friedlander, T., Prizak, R., Barton, N. H., & Tkačik, G. (2017). Evolution of new regulatory functions on biophysically realistic fitness landscapes. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/s41467-017-00238-8","mla":"Friedlander, Tamar, et al. “Evolution of New Regulatory Functions on Biophysically Realistic Fitness Landscapes.” Nature Communications, vol. 8, no. 1, 216, Nature Publishing Group, 2017, doi:10.1038/s41467-017-00238-8."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"291734","name":"International IST Postdoc Fellowship Programme"},{"name":"Limits to selection in biology and in evolutionary computation","grant_number":"250152","call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"254E9036-B435-11E9-9278-68D0E5697425","name":"Biophysics of information processing in gene regulation","grant_number":"P28844-B27"}],"article_number":"216","doi":"10.1038/s41467-017-00238-8","date_published":"2017-08-09T00:00:00Z","date_created":"2018-12-11T11:49:23Z","isi":1,"has_accepted_license":"1","year":"2017","day":"09","publication":"Nature Communications","publisher":"Nature Publishing Group","quality_controlled":"1","oa":1},{"citation":{"chicago":"Barzanjeh, Shabir, Matthias Wulf, Matilda Peruzzo, Mahmoud Kalaee, Paul Dieterle, Oskar Painter, and Johannes M Fink. “Mechanical on Chip Microwave Circulator.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/s41467-017-01304-x.","ista":"Barzanjeh S, Wulf M, Peruzzo M, Kalaee M, Dieterle P, Painter O, Fink JM. 2017. Mechanical on chip microwave circulator. Nature Communications. 8(1), 1304.","mla":"Barzanjeh, Shabir, et al. “Mechanical on Chip Microwave Circulator.” Nature Communications, vol. 8, no. 1, 1304, Nature Publishing Group, 2017, doi:10.1038/s41467-017-01304-x.","ieee":"S. Barzanjeh et al., “Mechanical on chip microwave circulator,” Nature Communications, vol. 8, no. 1. Nature Publishing Group, 2017.","short":"S. Barzanjeh, M. Wulf, M. Peruzzo, M. Kalaee, P. Dieterle, O. Painter, J.M. Fink, Nature Communications 8 (2017).","apa":"Barzanjeh, S., Wulf, M., Peruzzo, M., Kalaee, M., Dieterle, P., Painter, O., & Fink, J. M. (2017). Mechanical on chip microwave circulator. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/s41467-017-01304-x","ama":"Barzanjeh S, Wulf M, Peruzzo M, et al. Mechanical on chip microwave circulator. Nature Communications. 2017;8(1). doi:10.1038/s41467-017-01304-x"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","external_id":{"isi":["000412999700021"]},"article_processing_charge":"Yes (in subscription journal)","publist_id":"6855","author":[{"last_name":"Barzanjeh","full_name":"Barzanjeh, Shabir","orcid":"0000-0003-0415-1423","first_name":"Shabir","id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Matthias","id":"45598606-F248-11E8-B48F-1D18A9856A87","full_name":"Wulf, Matthias","orcid":"0000-0001-6613-1378","last_name":"Wulf"},{"id":"3F920B30-F248-11E8-B48F-1D18A9856A87","first_name":"Matilda","orcid":"0000-0002-3415-4628","full_name":"Peruzzo, Matilda","last_name":"Peruzzo"},{"first_name":"Mahmoud","full_name":"Kalaee, Mahmoud","last_name":"Kalaee"},{"first_name":"Paul","last_name":"Dieterle","full_name":"Dieterle, Paul"},{"full_name":"Painter, Oskar","last_name":"Painter","first_name":"Oskar"},{"full_name":"Fink, Johannes M","orcid":"0000-0001-8112-028X","last_name":"Fink","first_name":"Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87"}],"title":"Mechanical on chip microwave circulator","article_number":"1304","project":[{"name":"Hybrid Optomechanical Technologies","grant_number":"732894","call_identifier":"H2020","_id":"257EB838-B435-11E9-9278-68D0E5697425"},{"grant_number":"707438","name":"Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination with cavity Optomechanics","_id":"258047B6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"year":"2017","isi":1,"has_accepted_license":"1","publication":"Nature Communications","day":"16","date_created":"2018-12-11T11:48:33Z","date_published":"2017-10-16T00:00:00Z","doi":"10.1038/s41467-017-01304-x","oa":1,"quality_controlled":"1","publisher":"Nature Publishing Group","date_updated":"2023-09-27T12:11:28Z","ddc":["539"],"department":[{"_id":"JoFi"}],"file_date_updated":"2020-07-14T12:48:06Z","_id":"798","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","pubrep_id":"867","status":"public","publication_status":"published","publication_identifier":{"issn":["20411723"]},"language":[{"iso":"eng"}],"file":[{"file_size":1467696,"date_updated":"2020-07-14T12:48:06Z","creator":"system","file_name":"IST-2017-867-v1+1_s41467-017-01304-x.pdf","date_created":"2018-12-12T10:15:25Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access","checksum":"b68dafa71d1834c23b742cd9987a3d5f","file_id":"5145"}],"ec_funded":1,"volume":8,"issue":"1","abstract":[{"lang":"eng","text":"Nonreciprocal circuit elements form an integral part of modern measurement and communication systems. Mathematically they require breaking of time-reversal symmetry, typically achieved using magnetic materials and more recently using the quantum Hall effect, parametric permittivity modulation or Josephson nonlinearities. Here we demonstrate an on-chip magnetic-free circulator based on reservoir-engineered electromechanic interactions. Directional circulation is achieved with controlled phase-sensitive interference of six distinct electro-mechanical signal conversion paths. The presented circulator is compact, its silicon-on-insulator platform is compatible with both superconducting qubits and silicon photonics, and its noise performance is close to the quantum limit. With a high dynamic range, a tunable bandwidth of up to 30 MHz and an in situ reconfigurability as beam splitter or wavelength converter, it could pave the way for superconducting qubit processors with multiplexed on-chip signal processing and readout."}],"oa_version":"Published Version","scopus_import":"1","intvolume":" 8","month":"10"}]