[{"title":"Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons","publist_id":"6813","author":[{"last_name":"Makhijani","full_name":"Makhijani, Kalpana","first_name":"Kalpana"},{"first_name":"Brandy","full_name":"Alexander, Brandy","last_name":"Alexander"},{"first_name":"Deepti","full_name":"Rao, Deepti","last_name":"Rao"},{"first_name":"Sophia","last_name":"Petraki","full_name":"Petraki, Sophia"},{"last_name":"Herboso","full_name":"Herboso, Leire","first_name":"Leire"},{"first_name":"Katelyn","last_name":"Kukar","full_name":"Kukar, Katelyn"},{"full_name":"Batool, Itrat","last_name":"Batool","first_name":"Itrat"},{"full_name":"Wachner, Stephanie","last_name":"Wachner","id":"2A95E7B0-F248-11E8-B48F-1D18A9856A87","first_name":"Stephanie"},{"full_name":"Gold, Katrina","last_name":"Gold","first_name":"Katrina"},{"first_name":"Corinna","full_name":"Wong, Corinna","last_name":"Wong"},{"first_name":"Michael","last_name":"O'Connor","full_name":"O'Connor, Michael"},{"first_name":"Katja","full_name":"Brückner, Katja","last_name":"Brückner"}],"external_id":{"isi":["000406360100001"]},"article_processing_charge":"No","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ista":"Makhijani K, Alexander B, Rao D, Petraki S, Herboso L, Kukar K, Batool I, Wachner S, Gold K, Wong C, O’Connor M, Brückner K. 2017. Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons. Nature Communications. 8, 15990.","chicago":"Makhijani, Kalpana, Brandy Alexander, Deepti Rao, Sophia Petraki, Leire Herboso, Katelyn Kukar, Itrat Batool, et al. “Regulation of Drosophila Hematopoietic Sites by Activin-β from Active Sensory Neurons.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms15990.","short":"K. Makhijani, B. Alexander, D. Rao, S. Petraki, L. Herboso, K. Kukar, I. Batool, S. Wachner, K. Gold, C. Wong, M. O’Connor, K. Brückner, Nature Communications 8 (2017).","ieee":"K. Makhijani et al., “Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons,” Nature Communications, vol. 8. Nature Publishing Group, 2017.","apa":"Makhijani, K., Alexander, B., Rao, D., Petraki, S., Herboso, L., Kukar, K., … Brückner, K. (2017). Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms15990","ama":"Makhijani K, Alexander B, Rao D, et al. Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons. Nature Communications. 2017;8. doi:10.1038/ncomms15990","mla":"Makhijani, Kalpana, et al. “Regulation of Drosophila Hematopoietic Sites by Activin-β from Active Sensory Neurons.” Nature Communications, vol. 8, 15990, Nature Publishing Group, 2017, doi:10.1038/ncomms15990."},"article_number":"15990","date_published":"2017-07-27T00:00:00Z","doi":"10.1038/ncomms15990","date_created":"2018-12-11T11:48:45Z","day":"27","publication":"Nature Communications","isi":1,"has_accepted_license":"1","year":"2017","publisher":"Nature Publishing Group","quality_controlled":"1","oa":1,"file_date_updated":"2020-07-14T12:48:12Z","extern":"1","ddc":["570","576","616"],"date_updated":"2023-09-26T15:51:28Z","status":"public","pubrep_id":"859","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"_id":"835","volume":8,"file":[{"access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"5153","checksum":"99a3d63308d4250eda0a35341171f80e","creator":"system","date_updated":"2020-07-14T12:48:12Z","file_size":3027104,"date_created":"2018-12-12T10:15:32Z","file_name":"IST-2017-859-v1+1_ncomms15990.pdf"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["20411723"]},"publication_status":"published","month":"07","intvolume":" 8","oa_version":"Published Version","abstract":[{"text":"An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs. During Drosophila larval development, hematopoietic sites are in direct contact with sensory neuron clusters of the peripheral nervous system (PNS), and blood cells (hemocytes) require the PNS for their survival and recruitment to these microenvironments, known as Hematopoietic Pockets. Here we report that Activin-β, a TGF-β family ligand, is expressed by sensory neurons of the PNS and regulates the proliferation and adhesion of hemocytes. These hemocyte responses depend on PNS activity, as shown by agonist treatment and transient silencing of sensory neurons. Activin-β has a key role in this regulation, which is apparent from reporter expression and mutant analyses. This mechanism of local sensory neurons controlling blood cell adaptation invites evolutionary parallels with vertebrate hematopoietic progenitors and the independent myeloid system of tissue macrophages, whose regulation by local microenvironments remain undefined.","lang":"eng"}]},{"citation":{"chicago":"Strüber, Michael, Jonas Sauer, Peter M Jonas, and Marlene Bartos. “Distance-Dependent Inhibition Facilitates Focality of Gamma Oscillations in the Dentate Gyrus.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/s41467-017-00936-3.","ista":"Strüber M, Sauer J, Jonas PM, Bartos M. 2017. Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus. Nature Communications. 8(1), 758.","mla":"Strüber, Michael, et al. “Distance-Dependent Inhibition Facilitates Focality of Gamma Oscillations in the Dentate Gyrus.” Nature Communications, vol. 8, no. 1, 758, Nature Publishing Group, 2017, doi:10.1038/s41467-017-00936-3.","ieee":"M. Strüber, J. Sauer, P. M. Jonas, and M. Bartos, “Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus,” Nature Communications, vol. 8, no. 1. Nature Publishing Group, 2017.","short":"M. Strüber, J. Sauer, P.M. Jonas, M. Bartos, Nature Communications 8 (2017).","apa":"Strüber, M., Sauer, J., Jonas, P. M., & Bartos, M. (2017). Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/s41467-017-00936-3","ama":"Strüber M, Sauer J, Jonas PM, Bartos M. Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus. Nature Communications. 2017;8(1). doi:10.1038/s41467-017-00936-3"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Strüber, Michael","last_name":"Strüber","first_name":"Michael"},{"first_name":"Jonas","full_name":"Sauer, Jonas","last_name":"Sauer"},{"last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"},{"full_name":"Bartos, Marlene","last_name":"Bartos","first_name":"Marlene"}],"publist_id":"6853","article_processing_charge":"No","external_id":{"isi":["000412053100004"]},"title":"Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus","article_number":"758","project":[{"_id":"25C0F108-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"268548","name":"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons"}],"isi":1,"has_accepted_license":"1","year":"2017","day":"02","publication":"Nature Communications","date_published":"2017-10-02T00:00:00Z","doi":"10.1038/s41467-017-00936-3","date_created":"2018-12-11T11:48:34Z","quality_controlled":"1","publisher":"Nature Publishing Group","oa":1,"date_updated":"2023-09-27T10:59:41Z","ddc":["571"],"file_date_updated":"2020-07-14T12:48:07Z","department":[{"_id":"PeJo"}],"_id":"800","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","pubrep_id":"914","publication_identifier":{"issn":["20411723"]},"publication_status":"published","file":[{"date_created":"2018-12-12T10:15:17Z","file_name":"IST-2017-914-v1+1_s41467-017-00936-3.pdf","date_updated":"2020-07-14T12:48:07Z","file_size":4261832,"creator":"system","checksum":"7e2c7621afd5f802338e92e8619f024d","file_id":"5135","content_type":"application/pdf","access_level":"open_access","relation":"main_file"}],"language":[{"iso":"eng"}],"volume":8,"issue":"1","ec_funded":1,"abstract":[{"text":"Gamma oscillations (30–150 Hz) in neuronal networks are associated with the processing and recall of information. We measured local field potentials in the dentate gyrus of freely moving mice and found that gamma activity occurs in bursts, which are highly heterogeneous in their spatial extensions, ranging from focal to global coherent events. Synaptic communication among perisomatic-inhibitory interneurons (PIIs) is thought to play an important role in the generation of hippocampal gamma patterns. However, how neuronal circuits can generate synchronous oscillations at different spatial scales is unknown. We analyzed paired recordings in dentate gyrus slices and show that synaptic signaling at interneuron-interneuron synapses is distance dependent. Synaptic strength declines whereas the duration of inhibitory signals increases with axonal distance among interconnected PIIs. Using neuronal network modeling, we show that distance-dependent inhibition generates multiple highly synchronous focal gamma bursts allowing the network to process complex inputs in parallel in flexibly organized neuronal centers.","lang":"eng"}],"oa_version":"Published Version","scopus_import":"1","month":"10","intvolume":" 8"},{"ddc":["571"],"date_updated":"2023-09-27T12:27:30Z","department":[{"_id":"RySh"}],"file_date_updated":"2020-07-14T12:47:58Z","_id":"746","pubrep_id":"915","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","checksum":"99ceee57549dc0461e3adfc037ec70a9","file_id":"5287","file_size":1841650,"date_updated":"2020-07-14T12:47:58Z","creator":"system","file_name":"IST-2017-915-v1+1_s41467-017-01191-2.pdf","date_created":"2018-12-12T10:17:32Z"}],"publication_status":"published","publication_identifier":{"issn":["20411723"]},"issue":"1","volume":8,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Metabotropic glutamate receptor subtype 5 (mGluR5) is crucially implicated in the pathophysiology of Fragile X Syndrome (FXS); however, its dysfunction at the sub-cellular level, and related synaptic and cognitive phenotypes are unexplored. Here, we probed the consequences of mGluR5/Homer scaffold disruption for mGluR5 cell-surface mobility, synaptic N-methyl-D-Aspartate receptor (NMDAR) function, and behavioral phenotypes in the second-generation Fmr1 knockout (KO) mouse. Using single-molecule tracking, we found that mGluR5 was significantly more mobile at synapses in hippocampal Fmr1 KO neurons, causing an increased synaptic surface co-clustering of mGluR5 and NMDAR. This correlated with a reduced amplitude of synaptic NMDAR currents, a lack of their mGluR5-Activated long-Term depression, and NMDAR/hippocampus dependent cognitive deficits. These synaptic and behavioral phenomena were reversed by knocking down Homer1a in Fmr1 KO mice. Our study provides a mechanistic link between changes of mGluR5 dynamics and pathological phenotypes of FXS, unveiling novel targets for mGluR5-based therapeutics."}],"intvolume":" 8","month":"12","scopus_import":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ista":"Aloisi E, Le Corf K, Dupuis J, Zhang P, Ginger M, Labrousse V, Spatuzza M, Georg Haberl M, Costa L, Shigemoto R, Tappe Theodor A, Drago F, Vincenzo Piazza P, Mulle C, Groc L, Ciranna L, Catania M, Frick A. 2017. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature Communications. 8(1), 1103.","chicago":"Aloisi, Elisabetta, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, et al. “Altered Surface MGluR5 Dynamics Provoke Synaptic NMDAR Dysfunction and Cognitive Defects in Fmr1 Knockout Mice.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/s41467-017-01191-2.","ama":"Aloisi E, Le Corf K, Dupuis J, et al. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature Communications. 2017;8(1). doi:10.1038/s41467-017-01191-2","apa":"Aloisi, E., Le Corf, K., Dupuis, J., Zhang, P., Ginger, M., Labrousse, V., … Frick, A. (2017). Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/s41467-017-01191-2","ieee":"E. Aloisi et al., “Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice,” Nature Communications, vol. 8, no. 1. Nature Publishing Group, 2017.","short":"E. Aloisi, K. Le Corf, J. Dupuis, P. Zhang, M. Ginger, V. Labrousse, M. Spatuzza, M. Georg Haberl, L. Costa, R. Shigemoto, A. Tappe Theodor, F. Drago, P. Vincenzo Piazza, C. Mulle, L. Groc, L. Ciranna, M. Catania, A. Frick, Nature Communications 8 (2017).","mla":"Aloisi, Elisabetta, et al. “Altered Surface MGluR5 Dynamics Provoke Synaptic NMDAR Dysfunction and Cognitive Defects in Fmr1 Knockout Mice.” Nature Communications, vol. 8, no. 1, 1103, Nature Publishing Group, 2017, doi:10.1038/s41467-017-01191-2."},"title":"Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice","external_id":{"isi":["000413571300004"]},"article_processing_charge":"No","author":[{"first_name":"Elisabetta","last_name":"Aloisi","full_name":"Aloisi, Elisabetta"},{"first_name":"Katy","last_name":"Le Corf","full_name":"Le Corf, Katy"},{"first_name":"Julien","full_name":"Dupuis, Julien","last_name":"Dupuis"},{"first_name":"Pei","last_name":"Zhang","full_name":"Zhang, Pei"},{"last_name":"Ginger","full_name":"Ginger, Melanie","first_name":"Melanie"},{"first_name":"Virginie","last_name":"Labrousse","full_name":"Labrousse, Virginie"},{"last_name":"Spatuzza","full_name":"Spatuzza, Michela","first_name":"Michela"},{"first_name":"Matthias","full_name":"Georg Haberl, Matthias","last_name":"Georg Haberl"},{"first_name":"Lara","last_name":"Costa","full_name":"Costa, Lara"},{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Anke","full_name":"Tappe Theodor, Anke","last_name":"Tappe Theodor"},{"first_name":"Fillippo","last_name":"Drago","full_name":"Drago, Fillippo"},{"first_name":"Pier","full_name":"Vincenzo Piazza, Pier","last_name":"Vincenzo Piazza"},{"first_name":"Christophe","last_name":"Mulle","full_name":"Mulle, Christophe"},{"first_name":"Laurent","full_name":"Groc, Laurent","last_name":"Groc"},{"full_name":"Ciranna, Lucia","last_name":"Ciranna","first_name":"Lucia"},{"first_name":"Maria","full_name":"Catania, Maria","last_name":"Catania"},{"last_name":"Frick","full_name":"Frick, Andreas","first_name":"Andreas"}],"publist_id":"6921","article_number":"1103","publication":"Nature Communications","day":"01","year":"2017","isi":1,"has_accepted_license":"1","date_created":"2018-12-11T11:48:17Z","date_published":"2017-12-01T00:00:00Z","doi":"10.1038/s41467-017-01191-2","oa":1,"quality_controlled":"1","publisher":"Nature Publishing Group"},{"publication":"Nature Communications","day":"01","year":"2017","has_accepted_license":"1","date_created":"2018-12-11T11:47:30Z","date_published":"2017-12-01T00:00:00Z","doi":"10.1038/s41467-017-01663-5","oa":1,"publisher":"Nature Publishing Group","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Fraisse, Christelle, et al. “The Deep Conservation of the Lepidoptera Z Chromosome Suggests a Non Canonical Origin of the W.” Nature Communications, vol. 8, no. 1, 1486, Nature Publishing Group, 2017, doi:10.1038/s41467-017-01663-5.","ama":"Fraisse C, Picard MAL, Vicoso B. The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W. Nature Communications. 2017;8(1). doi:10.1038/s41467-017-01663-5","apa":"Fraisse, C., Picard, M. A. L., & Vicoso, B. (2017). The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/s41467-017-01663-5","short":"C. Fraisse, M.A.L. Picard, B. Vicoso, Nature Communications 8 (2017).","ieee":"C. Fraisse, M. A. L. Picard, and B. Vicoso, “The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W,” Nature Communications, vol. 8, no. 1. Nature Publishing Group, 2017.","chicago":"Fraisse, Christelle, Marion A L Picard, and Beatriz Vicoso. “The Deep Conservation of the Lepidoptera Z Chromosome Suggests a Non Canonical Origin of the W.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/s41467-017-01663-5.","ista":"Fraisse C, Picard MAL, Vicoso B. 2017. The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W. Nature Communications. 8(1), 1486."},"title":"The deep conservation of the Lepidoptera Z chromosome suggests a non canonical origin of the W","external_id":{"pmid":["29133797"]},"article_processing_charge":"No","author":[{"id":"32DF5794-F248-11E8-B48F-1D18A9856A87","first_name":"Christelle","last_name":"Fraisse","orcid":"0000-0001-8441-5075","full_name":"Fraisse, Christelle"},{"last_name":"Picard","orcid":"0000-0002-8101-2518","full_name":"Picard, Marion A","id":"2C921A7A-F248-11E8-B48F-1D18A9856A87","first_name":"Marion A"},{"first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306"}],"publist_id":"7190","article_number":"1486","project":[{"call_identifier":"FWF","_id":"250ED89C-B435-11E9-9278-68D0E5697425","name":"Sex chromosome evolution under male- and female- heterogamety","grant_number":"P28842-B22"}],"language":[{"iso":"eng"}],"file":[{"file_id":"7562","checksum":"4da2651303c8afc2f7fc419be42a2433","content_type":"application/pdf","access_level":"open_access","relation":"main_file","date_created":"2020-03-03T15:55:50Z","file_name":"2017_NatureComm_Fraisse.pdf","date_updated":"2020-07-14T12:47:20Z","file_size":1201520,"creator":"dernst"}],"publication_status":"published","publication_identifier":{"issn":["20411723"]},"issue":"1","related_material":{"record":[{"relation":"popular_science","status":"public","id":"7163"}]},"volume":8,"pmid":1,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Moths and butterflies (Lepidoptera) usually have a pair of differentiated WZ sex chromosomes. However, in most lineages outside of the division Ditrysia, as well as in the sister order Trichoptera, females lack a W chromosome. The W is therefore thought to have been acquired secondarily. Here we compare the genomes of three Lepidoptera species (one Dytrisia and two non-Dytrisia) to test three models accounting for the origin of the W: (1) a Z-autosome fusion; (2) a sex chromosome turnover; and (3) a non-canonical mechanism (e.g., through the recruitment of a B chromosome). We show that the gene content of the Z is highly conserved across Lepidoptera (rejecting a sex chromosome turnover) and that very few genes moved onto the Z in the common ancestor of the Ditrysia (arguing against a Z-autosome fusion). Our comparative genomics analysis therefore supports the secondary acquisition of the Lepidoptera W by a non-canonical mechanism, and it confirms the extreme stability of well-differentiated sex chromosomes."}],"intvolume":" 8","month":"12","scopus_import":1,"ddc":["570","576"],"date_updated":"2024-02-21T13:47:47Z","department":[{"_id":"BeVi"},{"_id":"NiBa"}],"file_date_updated":"2020-07-14T12:47:20Z","_id":"614","pubrep_id":"910","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","type":"journal_article"}]