---
_id: '12940'
abstract:
- lang: eng
text: Desorption electrospray ionization (DESI), easy ambient sonic-spray ionization
(EASI) and low-temperature plasma (LTP) ionization are powerful ambient ionization
techniques for mass spectrometry. However, every single method has its limitation
in terms of polarity and molecular weight of analyte molecules. After the miniaturization
of every possible component of the different ion sources, we finally were able
to embed two emitters and an ion transfer tubing into a small, hand-held device.
The pen-like interface is connected to the mass spectrometer and a separate control
unit via a bundle of flexible tubing and cables. The novel device allows the user
to ionize an extended range of chemicals by simple switching between DESI, voltage-free
EASI, or LTP ionization as well as to freely move the interface over a surface
of interest. A mini camera, which is mounted on the tip of the pen, magnifies
the desorption area and enables a simple positioning of the pen. The interface
was successfully tested using different types of chemicals, pharmaceuticals, and
real life samples. Moreover, the combination of optical data from the camera module
and chemical data obtained by mass analysis facilitates a novel type of imaging
mass spectrometry, which we name “interactive mass spectrometry imaging (IMSI)”.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Christina
full_name: Meisenbichler, Christina
last_name: Meisenbichler
- first_name: Florian
full_name: Kluibenschedl, Florian
id: 7499e70e-eb2c-11ec-b98b-f925648bc9d9
last_name: Kluibenschedl
- first_name: Thomas
full_name: Müller, Thomas
last_name: Müller
citation:
ama: Meisenbichler C, Kluibenschedl F, Müller T. A 3-in-1 hand-held ambient mass
spectrometry interface for identification and 2D localization of chemicals on
surfaces. Analytical Chemistry. 2020;92(21):14314-14318. doi:10.1021/acs.analchem.0c02615
apa: Meisenbichler, C., Kluibenschedl, F., & Müller, T. (2020). A 3-in-1 hand-held
ambient mass spectrometry interface for identification and 2D localization of
chemicals on surfaces. Analytical Chemistry. American Chemical Society.
https://doi.org/10.1021/acs.analchem.0c02615
chicago: Meisenbichler, Christina, Florian Kluibenschedl, and Thomas Müller. “A
3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D
Localization of Chemicals on Surfaces.” Analytical Chemistry. American
Chemical Society, 2020. https://doi.org/10.1021/acs.analchem.0c02615.
ieee: C. Meisenbichler, F. Kluibenschedl, and T. Müller, “A 3-in-1 hand-held ambient
mass spectrometry interface for identification and 2D localization of chemicals
on surfaces,” Analytical Chemistry, vol. 92, no. 21. American Chemical
Society, pp. 14314–14318, 2020.
ista: Meisenbichler C, Kluibenschedl F, Müller T. 2020. A 3-in-1 hand-held ambient
mass spectrometry interface for identification and 2D localization of chemicals
on surfaces. Analytical Chemistry. 92(21), 14314–14318.
mla: Meisenbichler, Christina, et al. “A 3-in-1 Hand-Held Ambient Mass Spectrometry
Interface for Identification and 2D Localization of Chemicals on Surfaces.” Analytical
Chemistry, vol. 92, no. 21, American Chemical Society, 2020, pp. 14314–18,
doi:10.1021/acs.analchem.0c02615.
short: C. Meisenbichler, F. Kluibenschedl, T. Müller, Analytical Chemistry 92 (2020)
14314–14318.
date_created: 2023-05-10T14:50:19Z
date_published: 2020-10-16T00:00:00Z
date_updated: 2023-05-15T08:01:20Z
day: '16'
doi: 10.1021/acs.analchem.0c02615
extern: '1'
external_id:
pmid:
- '33063994'
intvolume: ' 92'
issue: '21'
keyword:
- Analytical Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1021/acs.analchem.0c02615
month: '10'
oa: 1
oa_version: Published Version
page: 14314-14318
pmid: 1
publication: Analytical Chemistry
publication_identifier:
issn:
- 0003-2700
- 1520-6882
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: A 3-in-1 hand-held ambient mass spectrometry interface for identification and
2D localization of chemicals on surfaces
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 92
year: '2020'
...
---
_id: '7300'
abstract:
- lang: eng
text: Photoinduced electron transfer (PET), which causes pH-dependent quenching
of fluorescent dyes, is more effectively introduced by phenolic groups than by
amino groups which have been much more commonly used so far. That is demonstrated
by fluorescence measurements involving several classes of fluorophores. Electrochemical
measurements show that PET in several amino-modified dyes is thermodynamically
favorable, even though it was not experimentally found, underlining the importance
of kinetic aspects to the process. Consequently, the attachment of phenolic groups
allows for fast and simple preparation of a wide selection of fluorescent pH-probes
with tailor-made spectral properties, sensitive ranges, and individual advantages,
so that a large number of applications can be realized. Fluorophores carrying
phenolic groups may also be used for sensing analytes other than pH or molecular
switching and signaling.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
full_name: Aigner, Daniel
last_name: Aigner
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Martin
full_name: Wilkening, Martin
last_name: Wilkening
- first_name: Robert
full_name: Saf, Robert
last_name: Saf
- first_name: Sergey M.
full_name: Borisov, Sergey M.
last_name: Borisov
- first_name: Ingo
full_name: Klimant, Ingo
last_name: Klimant
citation:
ama: Aigner D, Freunberger SA, Wilkening M, Saf R, Borisov SM, Klimant I. Enhancing
photoinduced electron transfer efficiency of fluorescent pH-probes with halogenated
phenols. Analytical Chemistry. 2014;86(18):9293-9300. doi:10.1021/ac502513g
apa: Aigner, D., Freunberger, S. A., Wilkening, M., Saf, R., Borisov, S. M., &
Klimant, I. (2014). Enhancing photoinduced electron transfer efficiency of fluorescent
pH-probes with halogenated phenols. Analytical Chemistry. ACS. https://doi.org/10.1021/ac502513g
chicago: Aigner, Daniel, Stefan Alexander Freunberger, Martin Wilkening, Robert
Saf, Sergey M. Borisov, and Ingo Klimant. “Enhancing Photoinduced Electron Transfer
Efficiency of Fluorescent PH-Probes with Halogenated Phenols.” Analytical Chemistry.
ACS, 2014. https://doi.org/10.1021/ac502513g.
ieee: D. Aigner, S. A. Freunberger, M. Wilkening, R. Saf, S. M. Borisov, and I.
Klimant, “Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes
with halogenated phenols,” Analytical Chemistry, vol. 86, no. 18. ACS,
pp. 9293–9300, 2014.
ista: Aigner D, Freunberger SA, Wilkening M, Saf R, Borisov SM, Klimant I. 2014.
Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes with
halogenated phenols. Analytical Chemistry. 86(18), 9293–9300.
mla: Aigner, Daniel, et al. “Enhancing Photoinduced Electron Transfer Efficiency
of Fluorescent PH-Probes with Halogenated Phenols.” Analytical Chemistry,
vol. 86, no. 18, ACS, 2014, pp. 9293–300, doi:10.1021/ac502513g.
short: D. Aigner, S.A. Freunberger, M. Wilkening, R. Saf, S.M. Borisov, I. Klimant,
Analytical Chemistry 86 (2014) 9293–9300.
date_created: 2020-01-15T12:17:17Z
date_published: 2014-08-14T00:00:00Z
date_updated: 2021-01-12T08:12:53Z
day: '14'
doi: 10.1021/ac502513g
extern: '1'
intvolume: ' 86'
issue: '18'
language:
- iso: eng
month: '08'
oa_version: None
page: 9293-9300
publication: Analytical Chemistry
publication_identifier:
issn:
- 0003-2700
- 1520-6882
publication_status: published
publisher: ACS
quality_controlled: '1'
status: public
title: Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes
with halogenated phenols
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 86
year: '2014'
...