--- _id: '12940' abstract: - lang: eng text: Desorption electrospray ionization (DESI), easy ambient sonic-spray ionization (EASI) and low-temperature plasma (LTP) ionization are powerful ambient ionization techniques for mass spectrometry. However, every single method has its limitation in terms of polarity and molecular weight of analyte molecules. After the miniaturization of every possible component of the different ion sources, we finally were able to embed two emitters and an ion transfer tubing into a small, hand-held device. The pen-like interface is connected to the mass spectrometer and a separate control unit via a bundle of flexible tubing and cables. The novel device allows the user to ionize an extended range of chemicals by simple switching between DESI, voltage-free EASI, or LTP ionization as well as to freely move the interface over a surface of interest. A mini camera, which is mounted on the tip of the pen, magnifies the desorption area and enables a simple positioning of the pen. The interface was successfully tested using different types of chemicals, pharmaceuticals, and real life samples. Moreover, the combination of optical data from the camera module and chemical data obtained by mass analysis facilitates a novel type of imaging mass spectrometry, which we name “interactive mass spectrometry imaging (IMSI)”. article_processing_charge: No article_type: letter_note author: - first_name: Christina full_name: Meisenbichler, Christina last_name: Meisenbichler - first_name: Florian full_name: Kluibenschedl, Florian id: 7499e70e-eb2c-11ec-b98b-f925648bc9d9 last_name: Kluibenschedl - first_name: Thomas full_name: Müller, Thomas last_name: Müller citation: ama: Meisenbichler C, Kluibenschedl F, Müller T. A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. 2020;92(21):14314-14318. doi:10.1021/acs.analchem.0c02615 apa: Meisenbichler, C., Kluibenschedl, F., & Müller, T. (2020). A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. American Chemical Society. https://doi.org/10.1021/acs.analchem.0c02615 chicago: Meisenbichler, Christina, Florian Kluibenschedl, and Thomas Müller. “A 3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D Localization of Chemicals on Surfaces.” Analytical Chemistry. American Chemical Society, 2020. https://doi.org/10.1021/acs.analchem.0c02615. ieee: C. Meisenbichler, F. Kluibenschedl, and T. Müller, “A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces,” Analytical Chemistry, vol. 92, no. 21. American Chemical Society, pp. 14314–14318, 2020. ista: Meisenbichler C, Kluibenschedl F, Müller T. 2020. A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. 92(21), 14314–14318. mla: Meisenbichler, Christina, et al. “A 3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D Localization of Chemicals on Surfaces.” Analytical Chemistry, vol. 92, no. 21, American Chemical Society, 2020, pp. 14314–18, doi:10.1021/acs.analchem.0c02615. short: C. Meisenbichler, F. Kluibenschedl, T. Müller, Analytical Chemistry 92 (2020) 14314–14318. date_created: 2023-05-10T14:50:19Z date_published: 2020-10-16T00:00:00Z date_updated: 2023-05-15T08:01:20Z day: '16' doi: 10.1021/acs.analchem.0c02615 extern: '1' external_id: pmid: - '33063994' intvolume: ' 92' issue: '21' keyword: - Analytical Chemistry language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1021/acs.analchem.0c02615 month: '10' oa: 1 oa_version: Published Version page: 14314-14318 pmid: 1 publication: Analytical Chemistry publication_identifier: issn: - 0003-2700 - 1520-6882 publication_status: published publisher: American Chemical Society quality_controlled: '1' scopus_import: '1' status: public title: A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 92 year: '2020' ... --- _id: '7300' abstract: - lang: eng text: Photoinduced electron transfer (PET), which causes pH-dependent quenching of fluorescent dyes, is more effectively introduced by phenolic groups than by amino groups which have been much more commonly used so far. That is demonstrated by fluorescence measurements involving several classes of fluorophores. Electrochemical measurements show that PET in several amino-modified dyes is thermodynamically favorable, even though it was not experimentally found, underlining the importance of kinetic aspects to the process. Consequently, the attachment of phenolic groups allows for fast and simple preparation of a wide selection of fluorescent pH-probes with tailor-made spectral properties, sensitive ranges, and individual advantages, so that a large number of applications can be realized. Fluorophores carrying phenolic groups may also be used for sensing analytes other than pH or molecular switching and signaling. article_processing_charge: No article_type: original author: - first_name: Daniel full_name: Aigner, Daniel last_name: Aigner - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 - first_name: Martin full_name: Wilkening, Martin last_name: Wilkening - first_name: Robert full_name: Saf, Robert last_name: Saf - first_name: Sergey M. full_name: Borisov, Sergey M. last_name: Borisov - first_name: Ingo full_name: Klimant, Ingo last_name: Klimant citation: ama: Aigner D, Freunberger SA, Wilkening M, Saf R, Borisov SM, Klimant I. Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes with halogenated phenols. Analytical Chemistry. 2014;86(18):9293-9300. doi:10.1021/ac502513g apa: Aigner, D., Freunberger, S. A., Wilkening, M., Saf, R., Borisov, S. M., & Klimant, I. (2014). Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes with halogenated phenols. Analytical Chemistry. ACS. https://doi.org/10.1021/ac502513g chicago: Aigner, Daniel, Stefan Alexander Freunberger, Martin Wilkening, Robert Saf, Sergey M. Borisov, and Ingo Klimant. “Enhancing Photoinduced Electron Transfer Efficiency of Fluorescent PH-Probes with Halogenated Phenols.” Analytical Chemistry. ACS, 2014. https://doi.org/10.1021/ac502513g. ieee: D. Aigner, S. A. Freunberger, M. Wilkening, R. Saf, S. M. Borisov, and I. Klimant, “Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes with halogenated phenols,” Analytical Chemistry, vol. 86, no. 18. ACS, pp. 9293–9300, 2014. ista: Aigner D, Freunberger SA, Wilkening M, Saf R, Borisov SM, Klimant I. 2014. Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes with halogenated phenols. Analytical Chemistry. 86(18), 9293–9300. mla: Aigner, Daniel, et al. “Enhancing Photoinduced Electron Transfer Efficiency of Fluorescent PH-Probes with Halogenated Phenols.” Analytical Chemistry, vol. 86, no. 18, ACS, 2014, pp. 9293–300, doi:10.1021/ac502513g. short: D. Aigner, S.A. Freunberger, M. Wilkening, R. Saf, S.M. Borisov, I. Klimant, Analytical Chemistry 86 (2014) 9293–9300. date_created: 2020-01-15T12:17:17Z date_published: 2014-08-14T00:00:00Z date_updated: 2021-01-12T08:12:53Z day: '14' doi: 10.1021/ac502513g extern: '1' intvolume: ' 86' issue: '18' language: - iso: eng month: '08' oa_version: None page: 9293-9300 publication: Analytical Chemistry publication_identifier: issn: - 0003-2700 - 1520-6882 publication_status: published publisher: ACS quality_controlled: '1' status: public title: Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes with halogenated phenols type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 86 year: '2014' ...