--- _id: '11051' abstract: - lang: eng text: Nuclear pore complexes (NPCs) bridge the nucleus and the cytoplasm and are indispensable for crucial cellular activities, such as bidirectional molecular trafficking and gene transcription regulation. The discovery of long-lived proteins (LLPs) in NPCs from postmitotic cells raises the exciting possibility that the maintenance of NPC integrity might play an inherent role in lifelong cell function. Age-dependent deterioration of NPCs and loss of nuclear integrity have been linked to age-related decline in postmitotic cell function and degenerative diseases. In this review, we discuss our current understanding of NPC maintenance in proliferating and postmitotic cells, and how malfunction of nucleoporins (Nups) might contribute to the pathogenesis of various neurodegenerative and cardiovascular diseases. article_processing_charge: No article_type: review author: - first_name: Jinqiang full_name: Liu, Jinqiang last_name: Liu - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Liu J, Hetzer M. Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. 2022;32(3):P216-227. doi:10.1016/j.tcb.2021.10.001 apa: Liu, J., & Hetzer, M. (2022). Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. Elsevier. https://doi.org/10.1016/j.tcb.2021.10.001 chicago: Liu, Jinqiang, and Martin Hetzer. “Nuclear Pore Complex Maintenance and Implications for Age-Related Diseases.” Trends in Cell Biology. Elsevier, 2022. https://doi.org/10.1016/j.tcb.2021.10.001. ieee: J. Liu and M. Hetzer, “Nuclear pore complex maintenance and implications for age-related diseases,” Trends in Cell Biology, vol. 32, no. 3. Elsevier, pp. P216-227, 2022. ista: Liu J, Hetzer M. 2022. Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. 32(3), P216-227. mla: Liu, Jinqiang, and Martin Hetzer. “Nuclear Pore Complex Maintenance and Implications for Age-Related Diseases.” Trends in Cell Biology, vol. 32, no. 3, Elsevier, 2022, pp. P216-227, doi:10.1016/j.tcb.2021.10.001. short: J. Liu, M. Hetzer, Trends in Cell Biology 32 (2022) P216-227. date_created: 2022-04-07T07:43:01Z date_published: 2022-03-01T00:00:00Z date_updated: 2022-07-18T08:58:33Z day: '01' doi: 10.1016/j.tcb.2021.10.001 extern: '1' external_id: pmid: - '34782239' intvolume: ' 32' issue: '3' keyword: - Cell Biology language: - iso: eng month: '03' oa_version: None page: P216-227 pmid: 1 publication: Trends in Cell Biology publication_identifier: issn: - 0962-8924 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Nuclear pore complex maintenance and implications for age-related diseases type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 32 year: '2022' ... --- _id: '10705' abstract: - lang: eng text: Although rigidity and jamming transitions have been widely studied in physics and material science, their importance in a number of biological processes, including embryo development, tissue homeostasis, wound healing, and disease progression, has only begun to be recognized in the past few years. The hypothesis that biological systems can undergo rigidity/jamming transitions is attractive, as it would allow these systems to change their material properties rapidly and strongly. However, whether such transitions indeed occur in biological systems, how they are being regulated, and what their physiological relevance might be, is still being debated. Here, we review theoretical and experimental advances from the past few years, focusing on the regulation and role of potential tissue rigidity transitions in different biological processes. acknowledgement: We thank present and former members of the Heisenberg and Hannezo groups, in particular Bernat Corominas-Murtra and Nicoletta Petridou, for helpful discussions, and Claudia Flandoli for the artwork. We apologize for not being able to cite a number of highly relevant studies, to stay within the maximum allowed number of citations. article_processing_charge: No article_type: original author: - first_name: Edouard B full_name: Hannezo, Edouard B id: 3A9DB764-F248-11E8-B48F-1D18A9856A87 last_name: Hannezo orcid: 0000-0001-6005-1561 - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: Hannezo EB, Heisenberg C-PJ. Rigidity transitions in development and disease. Trends in Cell Biology. 2022;32(5):P433-444. doi:10.1016/j.tcb.2021.12.006 apa: Hannezo, E. B., & Heisenberg, C.-P. J. (2022). Rigidity transitions in development and disease. Trends in Cell Biology. Cell Press. https://doi.org/10.1016/j.tcb.2021.12.006 chicago: Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Rigidity Transitions in Development and Disease.” Trends in Cell Biology. Cell Press, 2022. https://doi.org/10.1016/j.tcb.2021.12.006. ieee: E. B. Hannezo and C.-P. J. Heisenberg, “Rigidity transitions in development and disease,” Trends in Cell Biology, vol. 32, no. 5. Cell Press, pp. P433-444, 2022. ista: Hannezo EB, Heisenberg C-PJ. 2022. Rigidity transitions in development and disease. Trends in Cell Biology. 32(5), P433-444. mla: Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Rigidity Transitions in Development and Disease.” Trends in Cell Biology, vol. 32, no. 5, Cell Press, 2022, pp. P433-444, doi:10.1016/j.tcb.2021.12.006. short: E.B. Hannezo, C.-P.J. Heisenberg, Trends in Cell Biology 32 (2022) P433-444. date_created: 2022-01-30T23:01:34Z date_published: 2022-05-01T00:00:00Z date_updated: 2023-08-02T14:03:53Z day: '01' department: - _id: EdHa - _id: CaHe doi: 10.1016/j.tcb.2021.12.006 external_id: isi: - '000795773900009' pmid: - '35058104' intvolume: ' 32' isi: 1 issue: '5' language: - iso: eng month: '05' oa_version: None page: P433-444 pmid: 1 publication: Trends in Cell Biology publication_identifier: eissn: - 1879-3088 issn: - 0962-8924 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: Rigidity transitions in development and disease type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 32 year: '2022' ... --- _id: '11083' abstract: - lang: eng text: Nuclear pore complex (NPC) proteins are known for their critical roles in regulating nucleocytoplasmic traffic of macromolecules across the nuclear envelope. However, recent findings suggest that some nucleoporins (Nups), including Nup98, have additional functions in developmental gene regulation. Nup98, which exhibits transcription-dependent mobility at the NPC but can also bind chromatin away from the nuclear envelope, is frequently involved in chromosomal translocations in a subset of patients suffering from acute myeloid leukemia (AML). A common paradigm suggests that Nup98 translocations cause aberrant transcription when they are recuited to aberrant genomic loci. Importantly, this model fails to account for the potential loss of wild type (WT) Nup98 function in the presence of Nup98 translocation mutants. Here we examine how the cell might regulate Nup98 nucleoplasmic protein levels to control transcription in healthy cells. In addition, we discuss the possibility that dominant negative Nup98 fusion proteins disrupt the transcriptional activity of WT Nup98 in the nucleoplasm to drive AML. article_processing_charge: No article_type: letter_note author: - first_name: Tobias M. full_name: Franks, Tobias M. last_name: Franks - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Franks TM, Hetzer M. The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biology. 2013;23(3):112-117. doi:10.1016/j.tcb.2012.10.013 apa: Franks, T. M., & Hetzer, M. (2013). The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biology. Elsevier. https://doi.org/10.1016/j.tcb.2012.10.013 chicago: Franks, Tobias M., and Martin Hetzer. “The Role of Nup98 in Transcription Regulation in Healthy and Diseased Cells.” Trends in Cell Biology. Elsevier, 2013. https://doi.org/10.1016/j.tcb.2012.10.013. ieee: T. M. Franks and M. Hetzer, “The role of Nup98 in transcription regulation in healthy and diseased cells,” Trends in Cell Biology, vol. 23, no. 3. Elsevier, pp. 112–117, 2013. ista: Franks TM, Hetzer M. 2013. The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biology. 23(3), 112–117. mla: Franks, Tobias M., and Martin Hetzer. “The Role of Nup98 in Transcription Regulation in Healthy and Diseased Cells.” Trends in Cell Biology, vol. 23, no. 3, Elsevier, 2013, pp. 112–17, doi:10.1016/j.tcb.2012.10.013. short: T.M. Franks, M. Hetzer, Trends in Cell Biology 23 (2013) 112–117. date_created: 2022-04-07T07:50:33Z date_published: 2013-03-01T00:00:00Z date_updated: 2022-07-18T08:45:34Z day: '01' doi: 10.1016/j.tcb.2012.10.013 extern: '1' external_id: pmid: - '23246429' intvolume: ' 23' issue: '3' keyword: - Cell Biology language: - iso: eng month: '03' oa_version: None page: 112-117 pmid: 1 publication: Trends in Cell Biology publication_identifier: issn: - 0962-8924 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: The role of Nup98 in transcription regulation in healthy and diseased cells type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 23 year: '2013' ... --- _id: '11110' abstract: - lang: eng text: Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario is inaccurate and that nuclear pore complexes are highly dynamic multiprotein assemblies involved in diverse cellular processes ranging from the organization of the cytoskeleton to gene expression. In this review, we discuss the most recent developments in the nuclear-pore-complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure. article_processing_charge: No article_type: review author: - first_name: Maximiliano A. full_name: D’Angelo, Maximiliano A. last_name: D’Angelo - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: D’Angelo MA, Hetzer M. Structure, dynamics and function of nuclear pore complexes. Trends in Cell Biology. 2008;18(10):456-466. doi:10.1016/j.tcb.2008.07.009 apa: D’Angelo, M. A., & Hetzer, M. (2008). Structure, dynamics and function of nuclear pore complexes. Trends in Cell Biology. Elsevier. https://doi.org/10.1016/j.tcb.2008.07.009 chicago: D’Angelo, Maximiliano A., and Martin Hetzer. “Structure, Dynamics and Function of Nuclear Pore Complexes.” Trends in Cell Biology. Elsevier, 2008. https://doi.org/10.1016/j.tcb.2008.07.009. ieee: M. A. D’Angelo and M. Hetzer, “Structure, dynamics and function of nuclear pore complexes,” Trends in Cell Biology, vol. 18, no. 10. Elsevier, pp. 456–466, 2008. ista: D’Angelo MA, Hetzer M. 2008. Structure, dynamics and function of nuclear pore complexes. Trends in Cell Biology. 18(10), 456–466. mla: D’Angelo, Maximiliano A., and Martin Hetzer. “Structure, Dynamics and Function of Nuclear Pore Complexes.” Trends in Cell Biology, vol. 18, no. 10, Elsevier, 2008, pp. 456–66, doi:10.1016/j.tcb.2008.07.009. short: M.A. D’Angelo, M. Hetzer, Trends in Cell Biology 18 (2008) 456–466. date_created: 2022-04-07T07:55:10Z date_published: 2008-10-01T00:00:00Z date_updated: 2022-07-18T08:55:33Z day: '01' doi: 10.1016/j.tcb.2008.07.009 extern: '1' external_id: pmid: - '18786826' intvolume: ' 18' issue: '10' keyword: - Cell Biology language: - iso: eng month: '10' oa_version: None page: 456-466 pmid: 1 publication: Trends in Cell Biology publication_identifier: issn: - 0962-8924 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Structure, dynamics and function of nuclear pore complexes type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 18 year: '2008' ...