---
_id: '12679'
abstract:
- lang: eng
text: How to generate a brain of correct size and with appropriate cell-type diversity
during development is a major question in Neuroscience. In the developing neocortex,
radial glial progenitor (RGP) cells are the main neural stem cells that produce
cortical excitatory projection neurons, glial cells, and establish the prospective
postnatal stem cell niche in the lateral ventricles. RGPs follow a tightly orchestrated
developmental program that when disrupted can result in severe cortical malformations
such as microcephaly and megalencephaly. The precise cellular and molecular mechanisms
instructing faithful RGP lineage progression are however not well understood.
This review will summarize recent conceptual advances that contribute to our understanding
of the general principles of RGP lineage progression.
acknowledgement: "I wish to thank all current and past members of the Hippenmeyer
laboratory at ISTA for exciting discussions on the subject of this review. I apologize
to colleagues whose work I could not cite and/or discuss in the frame of the available
space. Work in the Hippenmeyer laboratory on the\r\ndiscussed topic is supported
by ISTA institutional funds, FWF SFB F78 to S.H., and the European Research Council
(ERC) under the European Union’s Horizon 2020 Research and Innovation Programme
(grant agree-ment no. 725780 LinPro) to SH."
article_number: '102695'
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: 'Hippenmeyer S. Principles of neural stem cell lineage progression: Insights
from developing cerebral cortex. Current Opinion in Neurobiology. 2023;79(4).
doi:10.1016/j.conb.2023.102695'
apa: 'Hippenmeyer, S. (2023). Principles of neural stem cell lineage progression:
Insights from developing cerebral cortex. Current Opinion in Neurobiology.
Elsevier. https://doi.org/10.1016/j.conb.2023.102695'
chicago: 'Hippenmeyer, Simon. “Principles of Neural Stem Cell Lineage Progression:
Insights from Developing Cerebral Cortex.” Current Opinion in Neurobiology.
Elsevier, 2023. https://doi.org/10.1016/j.conb.2023.102695.'
ieee: 'S. Hippenmeyer, “Principles of neural stem cell lineage progression: Insights
from developing cerebral cortex,” Current Opinion in Neurobiology, vol.
79, no. 4. Elsevier, 2023.'
ista: 'Hippenmeyer S. 2023. Principles of neural stem cell lineage progression:
Insights from developing cerebral cortex. Current Opinion in Neurobiology. 79(4),
102695.'
mla: 'Hippenmeyer, Simon. “Principles of Neural Stem Cell Lineage Progression: Insights
from Developing Cerebral Cortex.” Current Opinion in Neurobiology, vol.
79, no. 4, 102695, Elsevier, 2023, doi:10.1016/j.conb.2023.102695.'
short: S. Hippenmeyer, Current Opinion in Neurobiology 79 (2023).
date_created: 2023-02-26T12:24:21Z
date_published: 2023-04-01T00:00:00Z
date_updated: 2023-08-16T12:30:25Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.conb.2023.102695
ec_funded: 1
external_id:
isi:
- '000953497700001'
pmid:
- '36842274'
file:
- access_level: open_access
checksum: 4d11c4ca87e6cbc4d2ac46d3225ea615
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T12:29:06Z
date_updated: 2023-08-16T12:29:06Z
file_id: '14071'
file_name: 2023_CurrentOpinionNeurobio_Hippenmeyer.pdf
file_size: 1787894
relation: main_file
success: 1
file_date_updated: 2023-08-16T12:29:06Z
has_accepted_license: '1'
intvolume: ' 79'
isi: 1
issue: '4'
keyword:
- General Neuroscience
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
grant_number: F07805
name: Molecular Mechanisms of Neural Stem Cell Lineage Progression
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Principles of neural stem cell lineage progression: Insights from developing
cerebral cortex'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 79
year: '2023'
...
---
_id: '8019'
abstract:
- lang: eng
text: Synaptic plasticity is essential for the function of neural systems. It sets
up initial circuitry and adjusts connection strengths according to the maintenance
requirements of its host networks. Like all things biological, synaptic plasticity
must rely on genetic programs to provide the molecular components of its machinery
to integrate ongoing, often multi-sensory experience without destabilising effects.
Because of its fundamental importance to healthy behaviour, understanding plasticity
is thought to hold the key to understanding the brain. There are innumerable ways
to approach this topic and a complete review of its status quo would be impossible.
In the current issue we dig into some of the finer points of synaptic plasticity,
starting small, at the level of genes, and slowly zooming out to synapses, populations
of synapses, and finally entire systems and brain regions. At each level, we tried
to represent different perspectives, different systems, and approaches to the
same questions to give a broad sampling of how synaptic plasticity is being studied.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: Leslie C
full_name: Griffith, Leslie C
last_name: Griffith
citation:
ama: 'Vogels TP, Griffith LC. Editorial overview: Neurobiology of learning and plasticity
2017. Current Opinion in Neurobiology. 2017;43:A1-A5. doi:10.1016/j.conb.2017.04.002'
apa: 'Vogels, T. P., & Griffith, L. C. (2017). Editorial overview: Neurobiology
of learning and plasticity 2017. Current Opinion in Neurobiology. Elsevier.
https://doi.org/10.1016/j.conb.2017.04.002'
chicago: 'Vogels, Tim P, and Leslie C Griffith. “Editorial Overview: Neurobiology
of Learning and Plasticity 2017.” Current Opinion in Neurobiology. Elsevier,
2017. https://doi.org/10.1016/j.conb.2017.04.002.'
ieee: 'T. P. Vogels and L. C. Griffith, “Editorial overview: Neurobiology of learning
and plasticity 2017,” Current Opinion in Neurobiology, vol. 43. Elsevier,
pp. A1–A5, 2017.'
ista: 'Vogels TP, Griffith LC. 2017. Editorial overview: Neurobiology of learning
and plasticity 2017. Current Opinion in Neurobiology. 43, A1–A5.'
mla: 'Vogels, Tim P., and Leslie C. Griffith. “Editorial Overview: Neurobiology
of Learning and Plasticity 2017.” Current Opinion in Neurobiology, vol.
43, Elsevier, 2017, pp. A1–5, doi:10.1016/j.conb.2017.04.002.'
short: T.P. Vogels, L.C. Griffith, Current Opinion in Neurobiology 43 (2017) A1–A5.
date_created: 2020-06-25T13:03:30Z
date_published: 2017-04-17T00:00:00Z
date_updated: 2021-01-12T08:16:33Z
day: '17'
doi: 10.1016/j.conb.2017.04.002
extern: '1'
external_id:
pmid:
- '28427877'
intvolume: ' 43'
language:
- iso: eng
month: '04'
oa_version: None
page: A1-A5
pmid: 1
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Editorial overview: Neurobiology of learning and plasticity 2017'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2017'
...
---
_id: '7699'
article_processing_charge: No
article_type: original
author:
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Darcy B
full_name: Kelley, Darcy B
last_name: Kelley
citation:
ama: Sweeney LB, Kelley DB. Harnessing vocal patterns for social communication.
Current Opinion in Neurobiology. 2014;28(10):34-41. doi:10.1016/j.conb.2014.06.006
apa: Sweeney, L. B., & Kelley, D. B. (2014). Harnessing vocal patterns for social
communication. Current Opinion in Neurobiology. Elsevier. https://doi.org/10.1016/j.conb.2014.06.006
chicago: Sweeney, Lora B., and Darcy B Kelley. “Harnessing Vocal Patterns for Social
Communication.” Current Opinion in Neurobiology. Elsevier, 2014. https://doi.org/10.1016/j.conb.2014.06.006.
ieee: L. B. Sweeney and D. B. Kelley, “Harnessing vocal patterns for social communication,”
Current Opinion in Neurobiology, vol. 28, no. 10. Elsevier, pp. 34–41,
2014.
ista: Sweeney LB, Kelley DB. 2014. Harnessing vocal patterns for social communication.
Current Opinion in Neurobiology. 28(10), 34–41.
mla: Sweeney, Lora B., and Darcy B. Kelley. “Harnessing Vocal Patterns for Social
Communication.” Current Opinion in Neurobiology, vol. 28, no. 10, Elsevier,
2014, pp. 34–41, doi:10.1016/j.conb.2014.06.006.
short: L.B. Sweeney, D.B. Kelley, Current Opinion in Neurobiology 28 (2014) 34–41.
date_created: 2020-04-30T10:35:39Z
date_published: 2014-10-01T00:00:00Z
date_updated: 2024-01-31T10:14:08Z
day: '01'
doi: 10.1016/j.conb.2014.06.006
extern: '1'
intvolume: ' 28'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 34-41
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Harnessing vocal patterns for social communication
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2014'
...
---
_id: '3460'
abstract:
- lang: eng
text: Excitatory postsynaptic currents in neurones of the central nervous system
have a dual-component time course that results from the co-activation of AMPA/kainate-type
and NMDA-type glutamate receptors. New approaches in electrophysiology and molecular
biology have provided a better understanding of the factors that determine the
kinectics of excitatory postsynaptic currents. Recent studies suggest that the
time course of neurotransmitter concentration in the synaptic cleft, the gating
properties of the native channels, and the glutamate receptor subunit composition
all appear to be important factors.
acknowledgement: 'We thank JGG Borst, N Burnashev, M Häusser, G Stuart and A Viilarroel
for critically reading the manuscript and E von Kitzing and A Roth for doing the
simulations and for many helpful discussions. Supported by the Deutsche Forschungsgemeinschaft
(SFB 317-B14) and the Alexander von Humboldt Foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Nelson
full_name: Spruston, Nelson
last_name: Spruston
citation:
ama: Jonas PM, Spruston N. Mechanisms shaping glutamate-mediated excitatory postsynaptic
currents in the CNS. Current Opinion in Neurobiology. 1994;4(3):366-372.
doi:10.1016/0959-4388(94)90098-1
apa: Jonas, P. M., & Spruston, N. (1994). Mechanisms shaping glutamate-mediated
excitatory postsynaptic currents in the CNS. Current Opinion in Neurobiology.
Elsevier. https://doi.org/10.1016/0959-4388(94)90098-1
chicago: Jonas, Peter M, and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated
Excitatory Postsynaptic Currents in the CNS.” Current Opinion in Neurobiology.
Elsevier, 1994. https://doi.org/10.1016/0959-4388(94)90098-1.
ieee: P. M. Jonas and N. Spruston, “Mechanisms shaping glutamate-mediated excitatory
postsynaptic currents in the CNS,” Current Opinion in Neurobiology, vol.
4, no. 3. Elsevier, pp. 366–372, 1994.
ista: Jonas PM, Spruston N. 1994. Mechanisms shaping glutamate-mediated excitatory
postsynaptic currents in the CNS. Current Opinion in Neurobiology. 4(3), 366–372.
mla: Jonas, Peter M., and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated
Excitatory Postsynaptic Currents in the CNS.” Current Opinion in Neurobiology,
vol. 4, no. 3, Elsevier, 1994, pp. 366–72, doi:10.1016/0959-4388(94)90098-1.
short: P.M. Jonas, N. Spruston, Current Opinion in Neurobiology 4 (1994) 366–372.
date_created: 2018-12-11T12:03:27Z
date_published: 1994-06-01T00:00:00Z
date_updated: 2022-06-03T11:26:52Z
day: '01'
doi: 10.1016/0959-4388(94)90098-1
extern: '1'
external_id:
pmid:
- '7522678 '
intvolume: ' 4'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0959438894900981?via%3Dihub
month: '06'
oa_version: None
page: 366 - 372
pmid: 1
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
publist_id: '2927'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the
CNS
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 4
year: '1994'
...