--- _id: '194' abstract: - lang: eng text: Ants are emerging model systems to study cellular signaling because distinct castes possess different physiologic phenotypes within the same colony. Here we studied the functionality of inotocin signaling, an insect ortholog of mammalian oxytocin (OT), which was recently discovered in ants. In Lasius ants, we determined that specialization within the colony, seasonal factors, and physiologic conditions down-regulated the expression of the OT-like signaling system. Given this natural variation, we interrogated its function using RNAi knockdowns. Next-generation RNA sequencing of OT-like precursor knock-down ants highlighted its role in the regulation of genes involved in metabolism. Knock-down ants exhibited higher walking activity and increased self-grooming in the brood chamber. We propose that OT-like signaling in ants is important for regulating metabolic processes and locomotion. article_processing_charge: No article_type: original author: - first_name: Zita full_name: Liutkeviciute, Zita last_name: Liutkeviciute - first_name: Esther full_name: Gil Mansilla, Esther last_name: Gil Mansilla - first_name: Thomas full_name: Eder, Thomas last_name: Eder - first_name: Barbara E full_name: Casillas Perez, Barbara E id: 351ED2AA-F248-11E8-B48F-1D18A9856A87 last_name: Casillas Perez - first_name: Maria full_name: Giulia Di Giglio, Maria last_name: Giulia Di Giglio - first_name: Edin full_name: Muratspahić, Edin last_name: Muratspahić - first_name: Florian full_name: Grebien, Florian last_name: Grebien - first_name: Thomas full_name: Rattei, Thomas last_name: Rattei - first_name: Markus full_name: Muttenthaler, Markus last_name: Muttenthaler - first_name: Sylvia full_name: Cremer, Sylvia id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87 last_name: Cremer orcid: 0000-0002-2193-3868 - first_name: Christian full_name: Gruber, Christian last_name: Gruber citation: ama: Liutkeviciute Z, Gil Mansilla E, Eder T, et al. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal. 2018;32(12):6808-6821. doi:10.1096/fj.201800443 apa: Liutkeviciute, Z., Gil Mansilla, E., Eder, T., Casillas Perez, B. E., Giulia Di Giglio, M., Muratspahić, E., … Gruber, C. (2018). Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal. FASEB. https://doi.org/10.1096/fj.201800443 chicago: Liutkeviciute, Zita, Esther Gil Mansilla, Thomas Eder, Barbara E Casillas Perez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, et al. “Oxytocin-like Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity.” The FASEB Journal. FASEB, 2018. https://doi.org/10.1096/fj.201800443. ieee: Z. Liutkeviciute et al., “Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity,” The FASEB Journal, vol. 32, no. 12. FASEB, pp. 6808–6821, 2018. ista: Liutkeviciute Z, Gil Mansilla E, Eder T, Casillas Perez BE, Giulia Di Giglio M, Muratspahić E, Grebien F, Rattei T, Muttenthaler M, Cremer S, Gruber C. 2018. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal. 32(12), 6808–6821. mla: Liutkeviciute, Zita, et al. “Oxytocin-like Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity.” The FASEB Journal, vol. 32, no. 12, FASEB, 2018, pp. 6808–21, doi:10.1096/fj.201800443. short: Z. Liutkeviciute, E. Gil Mansilla, T. Eder, B.E. Casillas Perez, M. Giulia Di Giglio, E. Muratspahić, F. Grebien, T. Rattei, M. Muttenthaler, S. Cremer, C. Gruber, The FASEB Journal 32 (2018) 6808–6821. date_created: 2018-12-11T11:45:08Z date_published: 2018-11-29T00:00:00Z date_updated: 2023-09-13T09:37:32Z day: '29' department: - _id: SyCr doi: 10.1096/fj.201800443 external_id: isi: - '000449359700035' pmid: - '29939785' intvolume: ' 32' isi: 1 issue: '12' language: - iso: eng main_file_link: - open_access: '1' url: ' https://doi.org/10.1096/fj.201800443' month: '11' oa: 1 oa_version: Published Version page: 6808-6821 pmid: 1 project: - _id: 25E3D34E-B435-11E9-9278-68D0E5697425 name: Individual function and social role of oxytocin-like neuropeptides in ants publication: The FASEB Journal publication_identifier: issn: - '08926638' publication_status: published publisher: FASEB publist_id: '7721' quality_controlled: '1' scopus_import: '1' status: public title: Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity type: journal_article user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 volume: 32 year: '2018' ...