--- _id: '15166' abstract: - lang: eng text: Reducing defects boosts room-temperature performance of a thermoelectric device acknowledgement: The authors thank the Werner-Siemens-Stiftung and the Institute of Science and Technology Austria for financial support. article_processing_charge: No article_type: letter_note author: - first_name: Navita full_name: Navita, Navita id: 6ebe278d-ba0b-11ee-8184-f34cdc671de4 last_name: Navita - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 citation: ama: Jakhar N, Ibáñez M. Electron highways are cooler. Science. 2024;383(6688):1184. doi:10.1126/science.ado4077 apa: Jakhar, N., & Ibáñez, M. (2024). Electron highways are cooler. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.ado4077 chicago: Jakhar, Navita, and Maria Ibáñez. “Electron Highways Are Cooler.” Science. American Association for the Advancement of Science, 2024. https://doi.org/10.1126/science.ado4077. ieee: N. Jakhar and M. Ibáñez, “Electron highways are cooler,” Science, vol. 383, no. 6688. American Association for the Advancement of Science, p. 1184, 2024. ista: Jakhar N, Ibáñez M. 2024. Electron highways are cooler. Science. 383(6688), 1184. mla: Jakhar, Navita, and Maria Ibáñez. “Electron Highways Are Cooler.” Science, vol. 383, no. 6688, American Association for the Advancement of Science, 2024, p. 1184, doi:10.1126/science.ado4077. short: N. Jakhar, M. Ibáñez, Science 383 (2024) 1184. date_created: 2024-03-24T23:00:58Z date_published: 2024-03-14T00:00:00Z date_updated: 2024-03-25T10:31:20Z day: '14' department: - _id: MaIb doi: 10.1126/science.ado4077 intvolume: ' 383' issue: '6688' language: - iso: eng month: '03' oa_version: None page: '1184' project: - _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery' publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: Electron highways are cooler type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 383 year: '2024' ... --- _id: '13106' abstract: - lang: eng text: Quantum entanglement is a key resource in currently developed quantum technologies. Sharing this fragile property between superconducting microwave circuits and optical or atomic systems would enable new functionalities, but this has been hindered by an energy scale mismatch of >104 and the resulting mutually imposed loss and noise. In this work, we created and verified entanglement between microwave and optical fields in a millikelvin environment. Using an optically pulsed superconducting electro-optical device, we show entanglement between propagating microwave and optical fields in the continuous variable domain. This achievement not only paves the way for entanglement between superconducting circuits and telecom wavelength light, but also has wide-ranging implications for hybrid quantum networks in the context of modularization, scaling, sensing, and cross-platform verification. acknowledgement: This work was supported by the European Research Council (grant no. 758053, ERC StG QUNNECT) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 899354, FETopen SuperQuLAN). L.Q. acknowledges generous support from the ISTFELLOW program. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 Research and Innovation Program (Marie Sklodowska-Curie grant no. 754411). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (grant no. F7105) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 862644, FETopen QUARTET). article_processing_charge: No article_type: original author: - first_name: Rishabh full_name: Sahu, Rishabh id: 47D26E34-F248-11E8-B48F-1D18A9856A87 last_name: Sahu orcid: 0000-0001-6264-2162 - first_name: Liu full_name: Qiu, Liu id: 45e99c0d-1eb1-11eb-9b96-ed8ab2983cac last_name: Qiu orcid: 0000-0003-4345-4267 - first_name: William J full_name: Hease, William J id: 29705398-F248-11E8-B48F-1D18A9856A87 last_name: Hease - first_name: Georg M full_name: Arnold, Georg M id: 3770C838-F248-11E8-B48F-1D18A9856A87 last_name: Arnold - first_name: Y. full_name: Minoguchi, Y. last_name: Minoguchi - first_name: P. full_name: Rabl, P. last_name: Rabl - first_name: Johannes M full_name: Fink, Johannes M id: 4B591CBA-F248-11E8-B48F-1D18A9856A87 last_name: Fink orcid: 0000-0001-8112-028X citation: ama: Sahu R, Qiu L, Hease WJ, et al. Entangling microwaves with light. Science. 2023;380(6646):718-721. doi:10.1126/science.adg3812 apa: Sahu, R., Qiu, L., Hease, W. J., Arnold, G. M., Minoguchi, Y., Rabl, P., & Fink, J. M. (2023). Entangling microwaves with light. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.adg3812 chicago: Sahu, Rishabh, Liu Qiu, William J Hease, Georg M Arnold, Y. Minoguchi, P. Rabl, and Johannes M Fink. “Entangling Microwaves with Light.” Science. American Association for the Advancement of Science, 2023. https://doi.org/10.1126/science.adg3812. ieee: R. Sahu et al., “Entangling microwaves with light,” Science, vol. 380, no. 6646. American Association for the Advancement of Science, pp. 718–721, 2023. ista: Sahu R, Qiu L, Hease WJ, Arnold GM, Minoguchi Y, Rabl P, Fink JM. 2023. Entangling microwaves with light. Science. 380(6646), 718–721. mla: Sahu, Rishabh, et al. “Entangling Microwaves with Light.” Science, vol. 380, no. 6646, American Association for the Advancement of Science, 2023, pp. 718–21, doi:10.1126/science.adg3812. short: R. Sahu, L. Qiu, W.J. Hease, G.M. Arnold, Y. Minoguchi, P. Rabl, J.M. Fink, Science 380 (2023) 718–721. date_created: 2023-05-31T11:39:24Z date_published: 2023-05-18T00:00:00Z date_updated: 2023-08-02T06:08:57Z day: '18' department: - _id: JoFi doi: 10.1126/science.adg3812 ec_funded: 1 external_id: arxiv: - '2301.03315' isi: - '000996515200004' intvolume: ' 380' isi: 1 issue: '6646' keyword: - Multidisciplinary language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2301.03315 month: '05' oa: 1 oa_version: Preprint page: 718-721 project: - _id: 26336814-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '758053' name: A Fiber Optic Transceiver for Superconducting Qubits - _id: 9B868D20-BA93-11EA-9121-9846C619BF3A call_identifier: H2020 grant_number: '899354' name: Quantum Local Area Networks with Superconducting Qubits - _id: 260C2330-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '754411' name: ISTplus - Postdoctoral Fellowships - _id: 26927A52-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: F07105 name: Integrating superconducting quantum circuits - _id: 237CBA6C-32DE-11EA-91FC-C7463DDC885E call_identifier: H2020 grant_number: '862644' name: Quantum readout techniques and technologies - _id: 2671EB66-B435-11E9-9278-68D0E5697425 name: Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' related_material: link: - description: News on ISTA Website relation: press_release url: https://ista.ac.at/en/news/wiring-up-quantum-circuits-with-light/ record: - id: '13122' relation: research_data status: public status: public title: Entangling microwaves with light type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 380 year: '2023' ... --- _id: '14281' abstract: - lang: eng text: In nature, proteins that switch between two conformations in response to environmental stimuli structurally transduce biochemical information in a manner analogous to how transistors control information flow in computing devices. Designing proteins with two distinct but fully structured conformations is a challenge for protein design as it requires sculpting an energy landscape with two distinct minima. Here we describe the design of “hinge” proteins that populate one designed state in the absence of ligand and a second designed state in the presence of ligand. X-ray crystallography, electron microscopy, double electron-electron resonance spectroscopy, and binding measurements demonstrate that despite the significant structural differences the two states are designed with atomic level accuracy and that the conformational and binding equilibria are closely coupled. article_processing_charge: No article_type: original author: - first_name: Florian M full_name: Praetorius, Florian M id: dfec9381-4341-11ee-8fd8-faa02bba7d62 last_name: Praetorius - first_name: Philip J. Y. full_name: Leung, Philip J. Y. last_name: Leung - first_name: Maxx H. full_name: Tessmer, Maxx H. last_name: Tessmer - first_name: Adam full_name: Broerman, Adam last_name: Broerman - first_name: Cullen full_name: Demakis, Cullen last_name: Demakis - first_name: Acacia F. full_name: Dishman, Acacia F. last_name: Dishman - first_name: Arvind full_name: Pillai, Arvind last_name: Pillai - first_name: Abbas full_name: Idris, Abbas last_name: Idris - first_name: David full_name: Juergens, David last_name: Juergens - first_name: Justas full_name: Dauparas, Justas last_name: Dauparas - first_name: Xinting full_name: Li, Xinting last_name: Li - first_name: Paul M. full_name: Levine, Paul M. last_name: Levine - first_name: Mila full_name: Lamb, Mila last_name: Lamb - first_name: Ryanne K. full_name: Ballard, Ryanne K. last_name: Ballard - first_name: Stacey R. full_name: Gerben, Stacey R. last_name: Gerben - first_name: Hannah full_name: Nguyen, Hannah last_name: Nguyen - first_name: Alex full_name: Kang, Alex last_name: Kang - first_name: Banumathi full_name: Sankaran, Banumathi last_name: Sankaran - first_name: Asim K. full_name: Bera, Asim K. last_name: Bera - first_name: Brian F. full_name: Volkman, Brian F. last_name: Volkman - first_name: Jeff full_name: Nivala, Jeff last_name: Nivala - first_name: Stefan full_name: Stoll, Stefan last_name: Stoll - first_name: David full_name: Baker, David last_name: Baker citation: ama: Praetorius FM, Leung PJY, Tessmer MH, et al. Design of stimulus-responsive two-state hinge proteins. Science. 2023;381(6659):754-760. doi:10.1126/science.adg7731 apa: Praetorius, F. M., Leung, P. J. Y., Tessmer, M. H., Broerman, A., Demakis, C., Dishman, A. F., … Baker, D. (2023). Design of stimulus-responsive two-state hinge proteins. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.adg7731 chicago: Praetorius, Florian M, Philip J. Y. Leung, Maxx H. Tessmer, Adam Broerman, Cullen Demakis, Acacia F. Dishman, Arvind Pillai, et al. “Design of Stimulus-Responsive Two-State Hinge Proteins.” Science. American Association for the Advancement of Science, 2023. https://doi.org/10.1126/science.adg7731. ieee: F. M. Praetorius et al., “Design of stimulus-responsive two-state hinge proteins,” Science, vol. 381, no. 6659. American Association for the Advancement of Science, pp. 754–760, 2023. ista: Praetorius FM, Leung PJY, Tessmer MH, Broerman A, Demakis C, Dishman AF, Pillai A, Idris A, Juergens D, Dauparas J, Li X, Levine PM, Lamb M, Ballard RK, Gerben SR, Nguyen H, Kang A, Sankaran B, Bera AK, Volkman BF, Nivala J, Stoll S, Baker D. 2023. Design of stimulus-responsive two-state hinge proteins. Science. 381(6659), 754–760. mla: Praetorius, Florian M., et al. “Design of Stimulus-Responsive Two-State Hinge Proteins.” Science, vol. 381, no. 6659, American Association for the Advancement of Science, 2023, pp. 754–60, doi:10.1126/science.adg7731. short: F.M. Praetorius, P.J.Y. Leung, M.H. Tessmer, A. Broerman, C. Demakis, A.F. Dishman, A. Pillai, A. Idris, D. Juergens, J. Dauparas, X. Li, P.M. Levine, M. Lamb, R.K. Ballard, S.R. Gerben, H. Nguyen, A. Kang, B. Sankaran, A.K. Bera, B.F. Volkman, J. Nivala, S. Stoll, D. Baker, Science 381 (2023) 754–760. date_created: 2023-09-06T12:04:23Z date_published: 2023-08-17T00:00:00Z date_updated: 2023-11-07T12:42:09Z day: '17' doi: 10.1126/science.adg7731 extern: '1' external_id: pmid: - '37590357' intvolume: ' 381' issue: '6659' language: - iso: eng month: '08' oa_version: None page: 754-760 pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: Design of stimulus-responsive two-state hinge proteins type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 381 year: '2023' ... --- _id: '15085' abstract: - lang: eng text: The hydrogen-rich outer layers of massive stars can be removed by interactions with a binary companion. Theoretical models predict that this stripping produces a population of hot helium stars of ~2 to 8 solar masses (M☉), however, only one such system has been identified thus far. We used ultraviolet photometry to identify potential stripped helium stars then investigated 25 of them using optical spectroscopy. We identified stars with high temperatures (~60,000 to 100,000 kelvin), high surface gravities, and hydrogen-depleted surfaces; 16 stars also showed binary motion. These properties match expectations for stars with initial masses of 8 to 25 M☉ that were stripped by binary interaction. Their masses fall in the gap between subdwarf helium stars and Wolf-Rayet stars. We propose that these stars could be progenitors of stripped-envelope supernovae. article_processing_charge: No article_type: original author: - first_name: M. R. full_name: Drout, M. R. last_name: Drout - first_name: Ylva Louise Linsdotter full_name: Götberg, Ylva Louise Linsdotter id: d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d last_name: Götberg orcid: 0000-0002-6960-6911 - first_name: B. A. full_name: Ludwig, B. A. last_name: Ludwig - first_name: J. H. full_name: Groh, J. H. last_name: Groh - first_name: S. E. full_name: de Mink, S. E. last_name: de Mink - first_name: A. J. G. full_name: O’Grady, A. J. G. last_name: O’Grady - first_name: N. full_name: Smith, N. last_name: Smith citation: ama: Drout MR, Götberg YLL, Ludwig BA, et al. An observed population of intermediate-mass helium stars that have been stripped in binaries. Science. 2023;382(6676):1287-1291. doi:10.1126/science.ade4970 apa: Drout, M. R., Götberg, Y. L. L., Ludwig, B. A., Groh, J. H., de Mink, S. E., O’Grady, A. J. G., & Smith, N. (2023). An observed population of intermediate-mass helium stars that have been stripped in binaries. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.ade4970 chicago: Drout, M. R., Ylva Louise Linsdotter Götberg, B. A. Ludwig, J. H. Groh, S. E. de Mink, A. J. G. O’Grady, and N. Smith. “An Observed Population of Intermediate-Mass Helium Stars That Have Been Stripped in Binaries.” Science. American Association for the Advancement of Science, 2023. https://doi.org/10.1126/science.ade4970. ieee: M. R. Drout et al., “An observed population of intermediate-mass helium stars that have been stripped in binaries,” Science, vol. 382, no. 6676. American Association for the Advancement of Science, pp. 1287–1291, 2023. ista: Drout MR, Götberg YLL, Ludwig BA, Groh JH, de Mink SE, O’Grady AJG, Smith N. 2023. An observed population of intermediate-mass helium stars that have been stripped in binaries. Science. 382(6676), 1287–1291. mla: Drout, M. R., et al. “An Observed Population of Intermediate-Mass Helium Stars That Have Been Stripped in Binaries.” Science, vol. 382, no. 6676, American Association for the Advancement of Science, 2023, pp. 1287–91, doi:10.1126/science.ade4970. short: M.R. Drout, Y.L.L. Götberg, B.A. Ludwig, J.H. Groh, S.E. de Mink, A.J.G. O’Grady, N. Smith, Science 382 (2023) 1287–1291. date_created: 2024-03-05T09:40:28Z date_published: 2023-12-14T00:00:00Z date_updated: 2024-03-13T07:40:04Z day: '14' doi: 10.1126/science.ade4970 extern: '1' external_id: arxiv: - '2307.00061' pmid: - '38096420' intvolume: ' 382' issue: '6676' keyword: - Stellar Astrophysics language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2307.00061 month: '12' oa: 1 oa_version: None page: 1287-1291 pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' related_material: link: - description: News on ISTA Website relation: press_release url: https://ista.ac.at/en/news/reaching-for-the-invisible-stars/ scopus_import: '1' status: public title: An observed population of intermediate-mass helium stars that have been stripped in binaries type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 382 year: '2023' ... --- _id: '11996' abstract: - lang: eng text: If you mix fruit syrups with alcohol to make a schnapps, the two liquids will remain perfectly blended forever. But if you mix oil with vinegar to make a vinaigrette, the oil and vinegar will soon separate back into their previous selves. Such liquid-liquid phase separation is a thermodynamically driven phenomenon and plays an important role in many biological processes (1). Although energy injection at the macroscale can reverse the phase separation—a strong shake is the normal response to a separated vinaigrette—little is known about the effect of energy added at the microscopic level on phase separation. This fundamental question has deep ramifications, notably in biology, because active processes also make the interior of a living cell different from a dead one. On page 768 of this issue, Adkins et al. (2) examine how mechanical activity at the microscopic scale affects liquid-liquid phase separation and allows liquids to climb surfaces. article_processing_charge: No article_type: letter_note author: - first_name: Jérémie A full_name: Palacci, Jérémie A id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d last_name: Palacci orcid: 0000-0002-7253-9465 citation: ama: Palacci JA. A soft active matter that can climb walls. Science. 2022;377(6607):710-711. doi:10.1126/science.adc9202 apa: Palacci, J. A. (2022). A soft active matter that can climb walls. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.adc9202 chicago: Palacci, Jérémie A. “A Soft Active Matter That Can Climb Walls.” Science. American Association for the Advancement of Science, 2022. https://doi.org/10.1126/science.adc9202. ieee: J. A. Palacci, “A soft active matter that can climb walls,” Science, vol. 377, no. 6607. American Association for the Advancement of Science, pp. 710–711, 2022. ista: Palacci JA. 2022. A soft active matter that can climb walls. Science. 377(6607), 710–711. mla: Palacci, Jérémie A. “A Soft Active Matter That Can Climb Walls.” Science, vol. 377, no. 6607, American Association for the Advancement of Science, 2022, pp. 710–11, doi:10.1126/science.adc9202. short: J.A. Palacci, Science 377 (2022) 710–711. date_created: 2022-08-28T22:02:00Z date_published: 2022-08-12T00:00:00Z date_updated: 2022-09-05T07:37:37Z day: '12' department: - _id: JePa doi: 10.1126/science.adc9202 external_id: pmid: - '35951689 ' intvolume: ' 377' issue: '6607' language: - iso: eng month: '08' oa_version: None page: 710-711 pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: A soft active matter that can climb walls type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 377 year: '2022' ... --- _id: '10713' abstract: - lang: eng text: Cells migrate through crowded microenvironments within tissues during normal development, immune response, and cancer metastasis. Although migration through pores and tracks in the extracellular matrix (ECM) has been well studied, little is known about cellular traversal into confining cell-dense tissues. We find that embryonic tissue invasion by Drosophila macrophages requires division of an epithelial ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM attachment formed by integrin-mediated focal adhesions next to mesodermal cells, allowing macrophages to move their nuclei ahead and invade between two immediately adjacent tissues. Invasion efficiency depends on division frequency, but reduction of adhesion strength allows macrophage entry independently of division. This work demonstrates that tissue dynamics can regulate cellular infiltration. acknowledged_ssus: - _id: Bio acknowledgement: 'We thank J. Friml, C. Guet, T. Hurd, M. Fendrych and members of the laboratory for comments on the manuscript; the Bioimaging Facility of IST Austria for excellent support and T. Lecuit, E. Hafen, R. Levayer and A. Martin for fly strains. This work was supported by a grant from the Austrian Science Fund FWF: Lise Meitner Fellowship M2379-B28 to M.A and D.S., and internal funding from IST Austria to D.S. and EMBL to S.D.R.' article_processing_charge: No article_type: original author: - first_name: Maria full_name: Akhmanova, Maria id: 3425EC26-F248-11E8-B48F-1D18A9856A87 last_name: Akhmanova orcid: 0000-0003-1522-3162 - first_name: Shamsi full_name: Emtenani, Shamsi id: 49D32318-F248-11E8-B48F-1D18A9856A87 last_name: Emtenani orcid: 0000-0001-6981-6938 - first_name: Daniel full_name: Krueger, Daniel last_name: Krueger - first_name: Attila full_name: György, Attila id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87 last_name: György orcid: 0000-0002-1819-198X - first_name: Mariana full_name: Pereira Guarda, Mariana id: 6de81d9d-e2f2-11eb-945a-af8bc2a60b26 last_name: Pereira Guarda - first_name: Mikhail full_name: Vlasov, Mikhail last_name: Vlasov - first_name: Fedor full_name: Vlasov, Fedor last_name: Vlasov - first_name: Andrei full_name: Akopian, Andrei last_name: Akopian - first_name: Aparna full_name: Ratheesh, Aparna id: 2F064CFE-F248-11E8-B48F-1D18A9856A87 last_name: Ratheesh - first_name: Stefano full_name: De Renzis, Stefano last_name: De Renzis - first_name: Daria E full_name: Siekhaus, Daria E id: 3D224B9E-F248-11E8-B48F-1D18A9856A87 last_name: Siekhaus orcid: 0000-0001-8323-8353 citation: ama: Akhmanova M, Emtenani S, Krueger D, et al. Cell division in tissues enables macrophage infiltration. Science. 2022;376(6591):394-396. doi:10.1126/science.abj0425 apa: Akhmanova, M., Emtenani, S., Krueger, D., György, A., Pereira Guarda, M., Vlasov, M., … Siekhaus, D. E. (2022). Cell division in tissues enables macrophage infiltration. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.abj0425 chicago: Akhmanova, Maria, Shamsi Emtenani, Daniel Krueger, Attila György, Mariana Pereira Guarda, Mikhail Vlasov, Fedor Vlasov, et al. “Cell Division in Tissues Enables Macrophage Infiltration.” Science. American Association for the Advancement of Science, 2022. https://doi.org/10.1126/science.abj0425. ieee: M. Akhmanova et al., “Cell division in tissues enables macrophage infiltration,” Science, vol. 376, no. 6591. American Association for the Advancement of Science, pp. 394–396, 2022. ista: Akhmanova M, Emtenani S, Krueger D, György A, Pereira Guarda M, Vlasov M, Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. 2022. Cell division in tissues enables macrophage infiltration. Science. 376(6591), 394–396. mla: Akhmanova, Maria, et al. “Cell Division in Tissues Enables Macrophage Infiltration.” Science, vol. 376, no. 6591, American Association for the Advancement of Science, 2022, pp. 394–96, doi:10.1126/science.abj0425. short: M. Akhmanova, S. Emtenani, D. Krueger, A. György, M. Pereira Guarda, M. Vlasov, F. Vlasov, A. Akopian, A. Ratheesh, S. De Renzis, D.E. Siekhaus, Science 376 (2022) 394–396. date_created: 2022-02-01T11:23:18Z date_published: 2022-04-22T00:00:00Z date_updated: 2023-08-02T14:06:15Z day: '22' department: - _id: DaSi doi: 10.1126/science.abj0425 external_id: isi: - '000788553700039' pmid: - '35446632' intvolume: ' 376' isi: 1 issue: '6591' language: - iso: eng license: https://creativecommons.org/licenses/by-nc-nd/4.0/ main_file_link: - open_access: '1' url: https://doi.org/10.1101/2021.04.19.438995 month: '04' oa: 1 oa_version: Preprint page: 394-396 pmid: 1 project: - _id: 264CBBAC-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: M02379 name: Modeling epithelial tissue mechanics during cell invasion publication: Science publication_identifier: issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' status: public title: Cell division in tissues enables macrophage infiltration tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 376 year: '2022' ... --- _id: '12116' abstract: - lang: eng text: Russia’s unprovoked attack on Ukraine has destroyed civilian infrastructure, including universities, research centers, and other academic infrastructure (1). Many Ukrainian scholars and researchers remain in Ukraine, and their work has suffered from major setbacks (2–4). We call on international scientists and institutions to support them. article_processing_charge: No article_type: letter_note author: - first_name: Karishma full_name: Chhugani, Karishma last_name: Chhugani - first_name: Alina full_name: Frolova, Alina last_name: Frolova - first_name: Yuriy full_name: Salyha, Yuriy last_name: Salyha - first_name: Andrada full_name: Fiscutean, Andrada last_name: Fiscutean - first_name: Oksana full_name: Zlenko, Oksana last_name: Zlenko - first_name: Sanita full_name: Reinsone, Sanita last_name: Reinsone - first_name: Walter W. full_name: Wolfsberger, Walter W. last_name: Wolfsberger - first_name: Oleksandra V. full_name: Ivashchenko, Oleksandra V. last_name: Ivashchenko - first_name: Megi full_name: Maci, Megi last_name: Maci - first_name: Dmytro full_name: Dziuba, Dmytro last_name: Dziuba - first_name: Andrii full_name: Parkhomenko, Andrii last_name: Parkhomenko - first_name: Eric full_name: Bortz, Eric last_name: Bortz - first_name: Fyodor full_name: Kondrashov, Fyodor id: 44FDEF62-F248-11E8-B48F-1D18A9856A87 last_name: Kondrashov orcid: 0000-0001-8243-4694 - first_name: Paweł P. full_name: Łabaj, Paweł P. last_name: Łabaj - first_name: Veronika full_name: Romero, Veronika last_name: Romero - first_name: Jakub full_name: Hlávka, Jakub last_name: Hlávka - first_name: Taras K. full_name: Oleksyk, Taras K. last_name: Oleksyk - first_name: Serghei full_name: Mangul, Serghei last_name: Mangul citation: ama: Chhugani K, Frolova A, Salyha Y, et al. Remote opportunities for scholars in Ukraine. Science. 2022;378(6626):1285-1286. doi:10.1126/science.adg0797 apa: Chhugani, K., Frolova, A., Salyha, Y., Fiscutean, A., Zlenko, O., Reinsone, S., … Mangul, S. (2022). Remote opportunities for scholars in Ukraine. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.adg0797 chicago: Chhugani, Karishma, Alina Frolova, Yuriy Salyha, Andrada Fiscutean, Oksana Zlenko, Sanita Reinsone, Walter W. Wolfsberger, et al. “Remote Opportunities for Scholars in Ukraine.” Science. American Association for the Advancement of Science, 2022. https://doi.org/10.1126/science.adg0797. ieee: K. Chhugani et al., “Remote opportunities for scholars in Ukraine,” Science, vol. 378, no. 6626. American Association for the Advancement of Science, pp. 1285–1286, 2022. ista: Chhugani K, Frolova A, Salyha Y, Fiscutean A, Zlenko O, Reinsone S, Wolfsberger WW, Ivashchenko OV, Maci M, Dziuba D, Parkhomenko A, Bortz E, Kondrashov F, Łabaj PP, Romero V, Hlávka J, Oleksyk TK, Mangul S. 2022. Remote opportunities for scholars in Ukraine. Science. 378(6626), 1285–1286. mla: Chhugani, Karishma, et al. “Remote Opportunities for Scholars in Ukraine.” Science, vol. 378, no. 6626, American Association for the Advancement of Science, 2022, pp. 1285–86, doi:10.1126/science.adg0797. short: K. Chhugani, A. Frolova, Y. Salyha, A. Fiscutean, O. Zlenko, S. Reinsone, W.W. Wolfsberger, O.V. Ivashchenko, M. Maci, D. Dziuba, A. Parkhomenko, E. Bortz, F. Kondrashov, P.P. Łabaj, V. Romero, J. Hlávka, T.K. Oleksyk, S. Mangul, Science 378 (2022) 1285–1286. date_created: 2023-01-12T11:56:30Z date_published: 2022-12-22T00:00:00Z date_updated: 2023-10-03T11:01:06Z day: '22' department: - _id: FyKo doi: 10.1126/science.adg0797 external_id: isi: - '000963463700023' intvolume: ' 378' isi: 1 issue: '6626' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1126/science.adg0797 month: '12' oa: 1 oa_version: Published Version page: 1285-1286 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: Remote opportunities for scholars in Ukraine type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 378 year: '2022' ... --- _id: '14282' abstract: - lang: eng text: Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must not only contain interfaces that enable reversible association but also be stable and well behaved in isolation. We use implicit negative design to generate β sheet–mediated heterodimers that can be assembled into a wide variety of complexes. The designs are stable, folded, and soluble in isolation and rapidly assemble upon mixing, and crystal structures are close to the computational models. We construct linearly arranged hetero-oligomers with up to six different components, branched hetero-oligomers, closed C4-symmetric two-component rings, and hetero-oligomers assembled on a cyclic homo-oligomeric central hub and demonstrate that such complexes can readily reconfigure through subunit exchange. Our approach provides a general route to designing asymmetric reconfigurable protein systems. article_number: abj7662 article_processing_charge: No article_type: original author: - first_name: Danny D. full_name: Sahtoe, Danny D. last_name: Sahtoe - first_name: Florian M full_name: Praetorius, Florian M id: dfec9381-4341-11ee-8fd8-faa02bba7d62 last_name: Praetorius - first_name: Alexis full_name: Courbet, Alexis last_name: Courbet - first_name: Yang full_name: Hsia, Yang last_name: Hsia - first_name: Basile I. M. full_name: Wicky, Basile I. M. last_name: Wicky - first_name: Natasha I. full_name: Edman, Natasha I. last_name: Edman - first_name: Lauren M. full_name: Miller, Lauren M. last_name: Miller - first_name: Bart J. R. full_name: Timmermans, Bart J. R. last_name: Timmermans - first_name: Justin full_name: Decarreau, Justin last_name: Decarreau - first_name: Hana M. full_name: Morris, Hana M. last_name: Morris - first_name: Alex full_name: Kang, Alex last_name: Kang - first_name: Asim K. full_name: Bera, Asim K. last_name: Bera - first_name: David full_name: Baker, David last_name: Baker citation: ama: Sahtoe DD, Praetorius FM, Courbet A, et al. Reconfigurable asymmetric protein assemblies through implicit negative design. Science. 2022;375(6578). doi:10.1126/science.abj7662 apa: Sahtoe, D. D., Praetorius, F. M., Courbet, A., Hsia, Y., Wicky, B. I. M., Edman, N. I., … Baker, D. (2022). Reconfigurable asymmetric protein assemblies through implicit negative design. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.abj7662 chicago: Sahtoe, Danny D., Florian M Praetorius, Alexis Courbet, Yang Hsia, Basile I. M. Wicky, Natasha I. Edman, Lauren M. Miller, et al. “Reconfigurable Asymmetric Protein Assemblies through Implicit Negative Design.” Science. American Association for the Advancement of Science, 2022. https://doi.org/10.1126/science.abj7662. ieee: D. D. Sahtoe et al., “Reconfigurable asymmetric protein assemblies through implicit negative design,” Science, vol. 375, no. 6578. American Association for the Advancement of Science, 2022. ista: Sahtoe DD, Praetorius FM, Courbet A, Hsia Y, Wicky BIM, Edman NI, Miller LM, Timmermans BJR, Decarreau J, Morris HM, Kang A, Bera AK, Baker D. 2022. Reconfigurable asymmetric protein assemblies through implicit negative design. Science. 375(6578), abj7662. mla: Sahtoe, Danny D., et al. “Reconfigurable Asymmetric Protein Assemblies through Implicit Negative Design.” Science, vol. 375, no. 6578, abj7662, American Association for the Advancement of Science, 2022, doi:10.1126/science.abj7662. short: D.D. Sahtoe, F.M. Praetorius, A. Courbet, Y. Hsia, B.I.M. Wicky, N.I. Edman, L.M. Miller, B.J.R. Timmermans, J. Decarreau, H.M. Morris, A. Kang, A.K. Bera, D. Baker, Science 375 (2022). date_created: 2023-09-06T12:05:42Z date_published: 2022-01-21T00:00:00Z date_updated: 2023-11-07T12:39:56Z day: '21' doi: 10.1126/science.abj7662 extern: '1' external_id: pmid: - '35050655' intvolume: ' 375' issue: '6578' language: - iso: eng month: '01' oa_version: None pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: Reconfigurable asymmetric protein assemblies through implicit negative design type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 375 year: '2022' ... --- _id: '10616' abstract: - lang: eng text: Electrons in moiré flat band systems can spontaneously break time-reversal symmetry, giving rise to a quantized anomalous Hall effect. In this study, we use a superconducting quantum interference device to image stray magnetic fields in twisted bilayer graphene aligned to hexagonal boron nitride. We find a magnetization of several Bohr magnetons per charge carrier, demonstrating that the magnetism is primarily orbital in nature. Our measurements reveal a large change in the magnetization as the chemical potential is swept across the quantum anomalous Hall gap, consistent with the expected contribution of chiral edge states to the magnetization of an orbital Chern insulator. Mapping the spatial evolution of field-driven magnetic reversal, we find a series of reproducible micrometer-scale domains pinned to structural disorder. acknowledgement: 'We thank A. H. Macdonald, J. Zhu, M. Zaletel, and D. Xiao for discussions of the results and E. Lachman for comments on the manuscript. Funding: The work was primarily funded by the US Department of Energy under DE-SC0020043, with additional support for instrumentation development supported by the Army Research Office under grant W911NF-16-1-0361. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by MEXT, Japan, grant JPMXP0112101001; JSPS KAKENHI grant JP20H00354 and CREST grant JPMJCR15F3, JST. C.L.T. acknowledges support from the Hertz Foundation and from the National Science Foundation Graduate Research Fellowship Program under grant 1650114. This project is funded in part by the Gordon and Betty Moore Foundation’s EPiQS Initiative, grant GBMF9471 to A.F.Y.' article_processing_charge: No article_type: original author: - first_name: C. L. full_name: Tschirhart, C. L. last_name: Tschirhart - first_name: M. full_name: Serlin, M. last_name: Serlin - first_name: Hryhoriy full_name: Polshyn, Hryhoriy id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48 last_name: Polshyn orcid: 0000-0001-8223-8896 - first_name: A. full_name: Shragai, A. last_name: Shragai - first_name: Z. full_name: Xia, Z. last_name: Xia - first_name: J. full_name: Zhu, J. last_name: Zhu - first_name: Y. full_name: Zhang, Y. last_name: Zhang - first_name: K. full_name: Watanabe, K. last_name: Watanabe - first_name: T. full_name: Taniguchi, T. last_name: Taniguchi - first_name: M. E. full_name: Huber, M. E. last_name: Huber - first_name: A. F. full_name: Young, A. F. last_name: Young citation: ama: Tschirhart CL, Serlin M, Polshyn H, et al. Imaging orbital ferromagnetism in a moiré Chern insulator. Science. 2021;372(6548):1323-1327. doi:10.1126/science.abd3190 apa: Tschirhart, C. L., Serlin, M., Polshyn, H., Shragai, A., Xia, Z., Zhu, J., … Young, A. F. (2021). Imaging orbital ferromagnetism in a moiré Chern insulator. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.abd3190 chicago: Tschirhart, C. L., M. Serlin, Hryhoriy Polshyn, A. Shragai, Z. Xia, J. Zhu, Y. Zhang, et al. “Imaging Orbital Ferromagnetism in a Moiré Chern Insulator.” Science. American Association for the Advancement of Science, 2021. https://doi.org/10.1126/science.abd3190. ieee: C. L. Tschirhart et al., “Imaging orbital ferromagnetism in a moiré Chern insulator,” Science, vol. 372, no. 6548. American Association for the Advancement of Science, pp. 1323–1327, 2021. ista: Tschirhart CL, Serlin M, Polshyn H, Shragai A, Xia Z, Zhu J, Zhang Y, Watanabe K, Taniguchi T, Huber ME, Young AF. 2021. Imaging orbital ferromagnetism in a moiré Chern insulator. Science. 372(6548), 1323–1327. mla: Tschirhart, C. L., et al. “Imaging Orbital Ferromagnetism in a Moiré Chern Insulator.” Science, vol. 372, no. 6548, American Association for the Advancement of Science, 2021, pp. 1323–27, doi:10.1126/science.abd3190. short: C.L. Tschirhart, M. Serlin, H. Polshyn, A. Shragai, Z. Xia, J. Zhu, Y. Zhang, K. Watanabe, T. Taniguchi, M.E. Huber, A.F. Young, Science 372 (2021) 1323–1327. date_created: 2022-01-13T12:17:45Z date_published: 2021-05-27T00:00:00Z date_updated: 2022-01-13T14:11:36Z day: '27' doi: 10.1126/science.abd3190 extern: '1' external_id: arxiv: - '2006.08053' pmid: - '34045322' intvolume: ' 372' issue: '6548' keyword: - multidisciplinary language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/2006.08053 month: '05' oa: 1 oa_version: Preprint page: 1323-1327 pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: Imaging orbital ferromagnetism in a moiré Chern insulator type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 372 year: '2021' ... --- _id: '12187' abstract: - lang: eng text: Genomes of germ cells present an existential vulnerability to organisms because germ cell mutations will propagate to future generations. Transposable elements are one source of such mutations. In the small flowering plant Arabidopsis, Long et al. found that genome methylation in the male germline is directed by small interfering RNAs (siRNAs) imperfectly transcribed from transposons (see the Perspective by Mosher). These germline siRNAs silence germline transposons and establish inherited methylation patterns in sperm, thus maintaining the integrity of the plant genome across generations. acknowledgement: 'We thank the John Innes Centre Bioimaging Facility (S. Lopez, E. Wegel, and K. Findlay) for their assistance with microscopy and the Norwich BioScience Institute Partnership Computing Infrastructure for Science Group for high-performance computing resources. Funding: This work was funded by a European Research Council Starting Grant (“SexMeth” 804981; J.L., J.W., and X.F.), a Sainsbury Charitable Foundation studentship (J.W.), two Biotechnology and Biological Sciences Research Council (BBSRC) grants (BBS0096201 and BBP0135111; W.S., M.V., and X.F.), two John Innes Foundation studentships (B.A. and S.D.), and a BBSRC David Phillips Fellowship (BBL0250431; H.G. and X.F.). Author contributions: J.L., J.W., and X.F. designed the study and wrote the manuscript; J.L., W.S., B.A., H.G., and S.D. performed the experiments; and J.L., J.W., B.A., H.G., S.D., M.V., and X.F. analyzed the data. Competing interests: The authors declare no competing interests. Data and material availability: All sequencing data have been deposited in the Gene Expression Omnibus (GEO) under accession no. GSE161625. Accession nos. of published datasets used in this study are listed in table S6. Published software used in this study include Bowtie v1.2.2 (https://doi.org/10.1002/0471250953.bi1107s32), Bismark v0.22.2 (https://doi.org/10.1093/bioinformatics/btr167), Kallisto v0.43.0 (https://doi.org/10.1038/nbt0816-888d), Shortstack v3.8.5 (https://doi.org/10.1534/g3.116.030452), and Cutadapt v1.15 (https://doi.org/10.1089/cmb.2017.0096). TrimGalore v0.4.1 and MarkDuplicates v1.141 are available from https://github.com/FelixKrueger/TrimGalore and https://github.com/broadinstitute/picard, respectively. All remaining data are in the main paper or the supplementary materials.' article_processing_charge: No article_type: original author: - first_name: Jincheng full_name: Long, Jincheng last_name: Long - first_name: James full_name: Walker, James last_name: Walker - first_name: Wenjing full_name: She, Wenjing last_name: She - first_name: Billy full_name: Aldridge, Billy last_name: Aldridge - first_name: Hongbo full_name: Gao, Hongbo last_name: Gao - first_name: Samuel full_name: Deans, Samuel last_name: Deans - first_name: Martin full_name: Vickers, Martin last_name: Vickers - first_name: Xiaoqi full_name: Feng, Xiaoqi id: e0164712-22ee-11ed-b12a-d80fcdf35958 last_name: Feng orcid: 0000-0002-4008-1234 citation: ama: Long J, Walker J, She W, et al. Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. Science. 2021;373(6550). doi:10.1126/science.abh0556 apa: Long, J., Walker, J., She, W., Aldridge, B., Gao, H., Deans, S., … Feng, X. (2021). Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. Science. American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/science.abh0556 chicago: Long, Jincheng, James Walker, Wenjing She, Billy Aldridge, Hongbo Gao, Samuel Deans, Martin Vickers, and Xiaoqi Feng. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic Inheritance in Arabidopsis.” Science. American Association for the Advancement of Science (AAAS), 2021. https://doi.org/10.1126/science.abh0556. ieee: J. Long et al., “Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis,” Science, vol. 373, no. 6550. American Association for the Advancement of Science (AAAS), 2021. ista: Long J, Walker J, She W, Aldridge B, Gao H, Deans S, Vickers M, Feng X. 2021. Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. Science. 373(6550). mla: Long, Jincheng, et al. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic Inheritance in Arabidopsis.” Science, vol. 373, no. 6550, American Association for the Advancement of Science (AAAS), 2021, doi:10.1126/science.abh0556. short: J. Long, J. Walker, W. She, B. Aldridge, H. Gao, S. Deans, M. Vickers, X. Feng, Science 373 (2021). date_created: 2023-01-16T09:15:14Z date_published: 2021-07-02T00:00:00Z date_updated: 2023-05-08T10:56:39Z day: '02' department: - _id: XiFe doi: 10.1126/science.abh0556 extern: '1' external_id: pmid: - '34210850' intvolume: ' 373' issue: '6550' keyword: - Multidisciplinary language: - iso: eng month: '07' oa_version: None pmid: 1 publication: Science publication_identifier: issn: - 0036-8075 - 1095-9203 publication_status: published publisher: American Association for the Advancement of Science (AAAS) quality_controlled: '1' scopus_import: '1' status: public title: Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 373 year: '2021' ...