---
_id: '8966'
abstract:
- lang: eng
text: During development, a single cell is transformed into a highly complex organism
through progressive cell division, specification and rearrangement. An important
prerequisite for the emergence of patterns within the developing organism is to
establish asymmetries at various scales, ranging from individual cells to the
entire embryo, eventually giving rise to the different body structures. This becomes
especially apparent during gastrulation, when the earliest major lineage restriction
events lead to the formation of the different germ layers. Traditionally, the
unfolding of the developmental program from symmetry breaking to germ layer formation
has been studied by dissecting the contributions of different signaling pathways
and cellular rearrangements in the in vivo context of intact embryos. Recent efforts,
using the intrinsic capacity of embryonic stem cells to self-assemble and generate
embryo-like structures de novo, have opened new avenues for understanding the
many ways by which an embryo can be built and the influence of extrinsic factors
therein. Here, we discuss and compare divergent and conserved strategies leading
to germ layer formation in embryos as compared to in vitro systems, their upstream
molecular cascades and the role of extrinsic factors in this process.
acknowledgement: We thank Nicoletta Petridou, Diana Pinheiro, Cornelia Schwayer and
Stefania Tavano for feedback on the manuscript. Research in the Heisenberg lab is
supported by an ERC Advanced Grant (MECSPEC 742573) to C.-P.H. A.S. is a recipient
of a DOC Fellowship of the Austrian Academy of Science.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Alexandra
full_name: Schauer, Alexandra
id: 30A536BA-F248-11E8-B48F-1D18A9856A87
last_name: Schauer
orcid: 0000-0001-7659-9142
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Schauer A, Heisenberg C-PJ. Reassembling gastrulation. Developmental Biology.
2021;474:71-81. doi:10.1016/j.ydbio.2020.12.014
apa: Schauer, A., & Heisenberg, C.-P. J. (2021). Reassembling gastrulation.
Developmental Biology. Elsevier. https://doi.org/10.1016/j.ydbio.2020.12.014
chicago: Schauer, Alexandra, and Carl-Philipp J Heisenberg. “Reassembling Gastrulation.”
Developmental Biology. Elsevier, 2021. https://doi.org/10.1016/j.ydbio.2020.12.014.
ieee: A. Schauer and C.-P. J. Heisenberg, “Reassembling gastrulation,” Developmental
Biology, vol. 474. Elsevier, pp. 71–81, 2021.
ista: Schauer A, Heisenberg C-PJ. 2021. Reassembling gastrulation. Developmental
Biology. 474, 71–81.
mla: Schauer, Alexandra, and Carl-Philipp J. Heisenberg. “Reassembling Gastrulation.”
Developmental Biology, vol. 474, Elsevier, 2021, pp. 71–81, doi:10.1016/j.ydbio.2020.12.014.
short: A. Schauer, C.-P.J. Heisenberg, Developmental Biology 474 (2021) 71–81.
date_created: 2020-12-22T09:53:34Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2023-08-07T13:30:01Z
day: '01'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1016/j.ydbio.2020.12.014
ec_funded: 1
external_id:
isi:
- '000639461800008'
file:
- access_level: open_access
checksum: fa2a5731fd16ab171b029f32f031c440
content_type: application/pdf
creator: kschuh
date_created: 2021-08-11T10:28:06Z
date_updated: 2021-08-11T10:28:06Z
file_id: '9880'
file_name: 2021_DevBiology_Schauer.pdf
file_size: 1440321
relation: main_file
success: 1
file_date_updated: 2021-08-11T10:28:06Z
has_accepted_license: '1'
intvolume: ' 474'
isi: 1
keyword:
- Developmental Biology
- Cell Biology
- Molecular Biology
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '06'
oa: 1
oa_version: Published Version
page: 71-81
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
- _id: 26B1E39C-B435-11E9-9278-68D0E5697425
grant_number: '25239'
name: 'Mesendoderm specification in zebrafish: The role of extraembryonic tissues'
publication: Developmental Biology
publication_identifier:
issn:
- 0012-1606
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '12891'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Reassembling gastrulation
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 474
year: '2021'
...
---
_id: '7545'
abstract:
- lang: eng
text: Neuronal activity often leads to alterations in gene expression and cellular
architecture. The nematode Caenorhabditis elegans, owing to its compact translucent
nervous system, is a powerful system in which to study conserved aspects of the
development and plasticity of neuronal morphology. Here we focus on one pair of
sensory neurons, termed URX, which the worm uses to sense and avoid high levels
of environmental oxygen. Previous studies have reported that the URX neuron pair
has variable branched endings at its dendritic sensory tip. By controlling oxygen
levels and analyzing mutants, we found that these microtubule-rich branched endings
grow over time as a consequence of neuronal activity in adulthood. We also find
that the growth of these branches correlates with an increase in cellular sensitivity
to particular ranges of oxygen that is observable in the behavior of older worms.
Given the strengths of C. elegans as a model organism, URX may serve as a potent
system for uncovering genes and mechanisms involved in activity-dependent morphological
changes in neurons and possible adaptive changes in the aging nervous system.
article_processing_charge: No
article_type: original
author:
- first_name: Jesse A.
full_name: Cohn, Jesse A.
last_name: Cohn
- first_name: Elizabeth R.
full_name: Cebul, Elizabeth R.
last_name: Cebul
- first_name: Giulio
full_name: Valperga, Giulio
last_name: Valperga
- first_name: Lotti
full_name: Brose, Lotti
last_name: Brose
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: Maxwell G.
full_name: Heiman, Maxwell G.
last_name: Heiman
- first_name: Jonathan T.
full_name: Pierce, Jonathan T.
last_name: Pierce
citation:
ama: Cohn JA, Cebul ER, Valperga G, et al. Long-term activity drives dendritic branch
elaboration of a C. elegans sensory neuron. Developmental Biology. 2020;461(1):66-74.
doi:10.1016/j.ydbio.2020.01.005
apa: Cohn, J. A., Cebul, E. R., Valperga, G., Brose, L., de Bono, M., Heiman, M.
G., & Pierce, J. T. (2020). Long-term activity drives dendritic branch elaboration
of a C. elegans sensory neuron. Developmental Biology. Elsevier. https://doi.org/10.1016/j.ydbio.2020.01.005
chicago: Cohn, Jesse A., Elizabeth R. Cebul, Giulio Valperga, Lotti Brose, Mario
de Bono, Maxwell G. Heiman, and Jonathan T. Pierce. “Long-Term Activity Drives
Dendritic Branch Elaboration of a C. Elegans Sensory Neuron.” Developmental
Biology. Elsevier, 2020. https://doi.org/10.1016/j.ydbio.2020.01.005.
ieee: J. A. Cohn et al., “Long-term activity drives dendritic branch elaboration
of a C. elegans sensory neuron,” Developmental Biology, vol. 461, no. 1.
Elsevier, pp. 66–74, 2020.
ista: Cohn JA, Cebul ER, Valperga G, Brose L, de Bono M, Heiman MG, Pierce JT. 2020.
Long-term activity drives dendritic branch elaboration of a C. elegans sensory
neuron. Developmental Biology. 461(1), 66–74.
mla: Cohn, Jesse A., et al. “Long-Term Activity Drives Dendritic Branch Elaboration
of a C. Elegans Sensory Neuron.” Developmental Biology, vol. 461, no. 1,
Elsevier, 2020, pp. 66–74, doi:10.1016/j.ydbio.2020.01.005.
short: J.A. Cohn, E.R. Cebul, G. Valperga, L. Brose, M. de Bono, M.G. Heiman, J.T.
Pierce, Developmental Biology 461 (2020) 66–74.
date_created: 2020-02-28T10:38:32Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2021-01-12T08:14:06Z
day: '01'
doi: 10.1016/j.ydbio.2020.01.005
extern: '1'
intvolume: ' 461'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/685339
month: '05'
oa: 1
oa_version: Preprint
page: 66-74
publication: Developmental Biology
publication_identifier:
issn:
- 0012-1606
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Long-term activity drives dendritic branch elaboration of a C. elegans sensory
neuron
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 461
year: '2020'
...