---
_id: '10301'
abstract:
- lang: eng
text: De novo protein synthesis is required for synapse modifications underlying
stable memory encoding. Yet neurons are highly compartmentalized cells and how
protein synthesis can be regulated at the synapse level is unknown. Here, we characterize
neuronal signaling complexes formed by the postsynaptic scaffold GIT1, the mechanistic
target of rapamycin (mTOR) kinase, and Raptor that couple synaptic stimuli to
mTOR-dependent protein synthesis; and identify NMDA receptors containing GluN3A
subunits as key negative regulators of GIT1 binding to mTOR. Disruption of GIT1/mTOR
complexes by enhancing GluN3A expression or silencing GIT1 inhibits synaptic mTOR
activation and restricts the mTOR-dependent translation of specific activity-regulated
mRNAs. Conversely, GluN3A removal enables complex formation, potentiates mTOR-dependent
protein synthesis, and facilitates the consolidation of associative and spatial
memories in mice. The memory enhancement becomes evident with light or spaced
training, can be achieved by selectively deleting GluN3A from excitatory neurons
during adulthood, and does not compromise other aspects of cognition such as memory
flexibility or extinction. Our findings provide mechanistic insight into synaptic
translational control and reveal a potentially selective target for cognitive
enhancement.
acknowledgement: We thank Stuart Lipton and Nobuki Nakanishi for providing the Grin3a
knockout mice, Beverly Davidson for the AAV-caRheb, Jose Esteban for help with behavioral
and biochemical experiments, and Noelia Campillo, Rebeca Martínez-Turrillas, and
Ana Navarro for expert technical help. Work was funded by the UTE project CIMA;
fellowships from the Fundación Tatiana Pérez de Guzmán el Bueno, FEBS, and IBRO
(to M.J.C.D.), Generalitat Valenciana (to O.E.-Z.), Juan de la Cierva (to L.G.R.),
FPI-MINECO (to E.R.V., to S.N.) and Intertalentum postdoctoral program (to V.B.);
ANR (GluBrain3A) and ERC Advanced Grants (#693021) (to P.P.); Ramón y Cajal program
RYC2014-15784, RETOS-MINECO SAF2016-76565-R, ERANET-Neuron JTC 2019 ISCIII AC19/00077
FEDER funds (to R.A.); RETOS-MINECO SAF2017-87928-R (to A.B.); an NIH grant (NS76637)
and UTHSC College of Medicine funds (to S.J.T.); and NARSAD Independent Investigator
Award and grants from the MINECO (CSD2008-00005, SAF2013-48983R, SAF2016-80895-R),
Generalitat Valenciana (PROMETEO 2019/020)(to I.P.O.) and Severo-Ochoa Excellence
Awards (SEV-2013-0317, SEV-2017-0723).
article_number: e71575
article_processing_charge: No
article_type: original
author:
- first_name: María J
full_name: Conde-Dusman, María J
last_name: Conde-Dusman
- first_name: Partha N
full_name: Dey, Partha N
last_name: Dey
- first_name: Óscar
full_name: Elía-Zudaire, Óscar
last_name: Elía-Zudaire
- first_name: Luis E
full_name: Garcia Rabaneda, Luis E
id: 33D1B084-F248-11E8-B48F-1D18A9856A87
last_name: Garcia Rabaneda
- first_name: Carmen
full_name: García-Lira, Carmen
last_name: García-Lira
- first_name: Teddy
full_name: Grand, Teddy
last_name: Grand
- first_name: Victor
full_name: Briz, Victor
last_name: Briz
- first_name: Eric R
full_name: Velasco, Eric R
last_name: Velasco
- first_name: Raül
full_name: Andero Galí, Raül
last_name: Andero Galí
- first_name: Sergio
full_name: Niñerola, Sergio
last_name: Niñerola
- first_name: Angel
full_name: Barco, Angel
last_name: Barco
- first_name: Pierre
full_name: Paoletti, Pierre
last_name: Paoletti
- first_name: John F
full_name: Wesseling, John F
last_name: Wesseling
- first_name: Fabrizio
full_name: Gardoni, Fabrizio
last_name: Gardoni
- first_name: Steven J
full_name: Tavalin, Steven J
last_name: Tavalin
- first_name: Isabel
full_name: Perez-Otaño, Isabel
last_name: Perez-Otaño
citation:
ama: Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, et al. Control of protein synthesis
and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
eLife. 2021;10. doi:10.7554/elife.71575
apa: Conde-Dusman, M. J., Dey, P. N., Elía-Zudaire, Ó., Garcia Rabaneda, L. E.,
García-Lira, C., Grand, T., … Perez-Otaño, I. (2021). Control of protein synthesis
and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.71575
chicago: Conde-Dusman, María J, Partha N Dey, Óscar Elía-Zudaire, Luis E Garcia
Rabaneda, Carmen García-Lira, Teddy Grand, Victor Briz, et al. “Control of Protein
Synthesis and Memory by GluN3A-NMDA Receptors through Inhibition of GIT1/MTORC1
Assembly.” ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.71575.
ieee: M. J. Conde-Dusman et al., “Control of protein synthesis and memory
by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly,” eLife,
vol. 10. eLife Sciences Publications, 2021.
ista: Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, Garcia Rabaneda LE, García-Lira C,
Grand T, Briz V, Velasco ER, Andero Galí R, Niñerola S, Barco A, Paoletti P, Wesseling
JF, Gardoni F, Tavalin SJ, Perez-Otaño I. 2021. Control of protein synthesis and
memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. eLife.
10, e71575.
mla: Conde-Dusman, María J., et al. “Control of Protein Synthesis and Memory by
GluN3A-NMDA Receptors through Inhibition of GIT1/MTORC1 Assembly.” ELife,
vol. 10, e71575, eLife Sciences Publications, 2021, doi:10.7554/elife.71575.
short: M.J. Conde-Dusman, P.N. Dey, Ó. Elía-Zudaire, L.E. Garcia Rabaneda, C. García-Lira,
T. Grand, V. Briz, E.R. Velasco, R. Andero Galí, S. Niñerola, A. Barco, P. Paoletti,
J.F. Wesseling, F. Gardoni, S.J. Tavalin, I. Perez-Otaño, ELife 10 (2021).
date_created: 2021-11-18T06:59:45Z
date_published: 2021-11-17T00:00:00Z
date_updated: 2023-08-14T11:50:50Z
day: '17'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.7554/elife.71575
external_id:
isi:
- '000720945900001'
file:
- access_level: open_access
checksum: 59318e9e41507cec83c2f4070e6ad540
content_type: application/pdf
creator: lgarciar
date_created: 2021-11-18T07:02:02Z
date_updated: 2021-11-18T07:02:02Z
file_id: '10302'
file_name: elife-71575-v1.pdf
file_size: 2477302
relation: main_file
success: 1
file_date_updated: 2021-11-18T07:02:02Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- general immunology and microbiology
- general biochemistry
- genetics and molecular biology
- general medicine
- general neuroscience
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
status: public
title: Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition
of GIT1/mTORC1 assembly
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '10283'
abstract:
- lang: eng
text: 'During the past decade, the scientific community and outside observers have
noted a concerning lack of rigor and transparency in preclinical research that
led to talk of a “reproducibility crisis” in the life sciences (Baker, 2016; Bespalov
& Steckler, 2018; Heddleston et al, 2021). Various measures have been proposed
to address the problem: from better training of scientists to more oversight to
expanded publishing practices such as preregistration of studies. The recently
published EQIPD (Enhancing Quality in Preclinical Data) System is, to date, the
largest initiative that aims to establish a systematic approach for increasing
the robustness and reliability of biomedical research (Bespalov et al, 2021).
However, promoting a cultural change in research practices warrants a broad adoption
of the Quality System and its underlying philosophy. It is here that academic
Core Facilities (CF), research service providers at universities and research
institutions, can make a difference. It is fair to assume that a significant fraction
of published data originated from experiments that were designed, run, or analyzed
in CFs. These academic services play an important role in the research ecosystem
by offering access to cutting-edge equipment and by developing and testing novel
techniques and methods that impact research in the academic and private sectors
alike (Bikovski et al, 2020). Equipment and infrastructure are not the only value:
CFs employ competent personnel with profound knowledge and practical experience
of the specific field of interest: animal behavior, imaging, crystallography,
genomics, and so on. Thus, CFs are optimally positioned to address concerns about
the quality and robustness of preclinical research.'
acknowledgement: This EQIPD project has received funding from the Innovative Medicines
Initiative 2 Joint Undertaking under grant agreement no. 777364. This Joint Undertaking
receives support from the European Union’s Horizon 2020 research and innovation
program and EFPIA. LR was supported by the Faculty of Biology and Medicine, University
of Lausanne. VV was supported by Biocenter Finland and the Jane and Aatos Erkko
Foundation. CP and IKB received funding from the Federal Ministry of Education and
Research (BMBF, grant 01PW18001). SB from the Vienna BioCenter Core Facilities (VBCF)
Preclinical Phenotyping Facility acknowledges funding from the Austrian Federal
Ministry of Education, Science & Research; and the City of Vienna. MT is an incumbent
of the Carolito Stiftung Research Fellow Chair in Neurodegenerative Diseases. We
thank Dr. Katja Kivinen (Helsinki Institute of Life Science) for discussions and
feedback.
article_number: e53824
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Leonardo
full_name: Restivo, Leonardo
last_name: Restivo
- first_name: Björn
full_name: Gerlach, Björn
last_name: Gerlach
- first_name: Michael
full_name: Tsoory, Michael
last_name: Tsoory
- first_name: Lior
full_name: Bikovski, Lior
last_name: Bikovski
- first_name: Sylvia
full_name: Badurek, Sylvia
last_name: Badurek
- first_name: Claudia
full_name: Pitzer, Claudia
last_name: Pitzer
- first_name: Isabelle C.
full_name: Kos-Braun, Isabelle C.
last_name: Kos-Braun
- first_name: Anne Laure Mj
full_name: Mausset-Bonnefont, Anne Laure Mj
last_name: Mausset-Bonnefont
- first_name: Jonathan
full_name: Ward, Jonathan
last_name: Ward
- first_name: Michael
full_name: Schunn, Michael
id: 4272DB4A-F248-11E8-B48F-1D18A9856A87
last_name: Schunn
orcid: 0000-0003-4326-5300
- first_name: Lucas P.J.J.
full_name: Noldus, Lucas P.J.J.
last_name: Noldus
- first_name: Anton
full_name: Bespalov, Anton
last_name: Bespalov
- first_name: Vootele
full_name: Voikar, Vootele
last_name: Voikar
citation:
ama: 'Restivo L, Gerlach B, Tsoory M, et al. Towards best practices in research:
Role of academic core facilities. EMBO Reports. 2021;22. doi:10.15252/embr.202153824'
apa: 'Restivo, L., Gerlach, B., Tsoory, M., Bikovski, L., Badurek, S., Pitzer, C.,
… Voikar, V. (2021). Towards best practices in research: Role of academic core
facilities. EMBO Reports. EMBO Press. https://doi.org/10.15252/embr.202153824'
chicago: 'Restivo, Leonardo, Björn Gerlach, Michael Tsoory, Lior Bikovski, Sylvia
Badurek, Claudia Pitzer, Isabelle C. Kos-Braun, et al. “Towards Best Practices
in Research: Role of Academic Core Facilities.” EMBO Reports. EMBO Press,
2021. https://doi.org/10.15252/embr.202153824.'
ieee: 'L. Restivo et al., “Towards best practices in research: Role of academic
core facilities,” EMBO Reports, vol. 22. EMBO Press, 2021.'
ista: 'Restivo L, Gerlach B, Tsoory M, Bikovski L, Badurek S, Pitzer C, Kos-Braun
IC, Mausset-Bonnefont ALM, Ward J, Schunn M, Noldus LPJJ, Bespalov A, Voikar V.
2021. Towards best practices in research: Role of academic core facilities. EMBO
Reports. 22, e53824.'
mla: 'Restivo, Leonardo, et al. “Towards Best Practices in Research: Role of Academic
Core Facilities.” EMBO Reports, vol. 22, e53824, EMBO Press, 2021, doi:10.15252/embr.202153824.'
short: L. Restivo, B. Gerlach, M. Tsoory, L. Bikovski, S. Badurek, C. Pitzer, I.C.
Kos-Braun, A.L.M. Mausset-Bonnefont, J. Ward, M. Schunn, L.P.J.J. Noldus, A. Bespalov,
V. Voikar, EMBO Reports 22 (2021).
date_created: 2021-11-14T23:01:24Z
date_published: 2021-11-04T00:00:00Z
date_updated: 2023-08-14T11:47:35Z
day: '04'
ddc:
- '570'
department:
- _id: PreCl
doi: 10.15252/embr.202153824
external_id:
isi:
- '000714350000001'
file:
- access_level: open_access
checksum: 74743baa6ef431ef60c3de3bc4da045a
content_type: application/pdf
creator: dernst
date_created: 2022-05-16T07:07:41Z
date_updated: 2022-05-16T07:07:41Z
file_id: '11381'
file_name: 2021_EmboReports_Restivo.pdf
file_size: 488583
relation: main_file
success: 1
file_date_updated: 2022-05-16T07:07:41Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '11'
oa: 1
oa_version: Published Version
publication: EMBO Reports
publication_identifier:
eissn:
- 1469-3178
issn:
- 1469-221X
publication_status: published
publisher: EMBO Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Towards best practices in research: Role of academic core facilities'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2021'
...
---
_id: '10310'
abstract:
- lang: eng
text: A high-resolution structure of trimeric cyanobacterial Photosystem I (PSI)
from Thermosynechococcus elongatus was reported as the first atomic model of PSI
almost 20 years ago. However, the monomeric PSI structure has not yet been reported
despite long-standing interest in its structure and extensive spectroscopic characterization
of the loss of red chlorophylls upon monomerization. Here, we describe the structure
of monomeric PSI from Thermosynechococcus elongatus BP-1. Comparison with the
trimer structure gave detailed insights into monomerization-induced changes in
both the central trimerization domain and the peripheral regions of the complex.
Monomerization-induced loss of red chlorophylls is assigned to a cluster of chlorophylls
adjacent to PsaX. Based on our findings, we propose a role of PsaX in the stabilization
of red chlorophylls and that lipids of the surrounding membrane present a major
source of thermal energy for uphill excitation energy transfer from red chlorophylls
to P700.
acknowledgement: We are grateful for additional support and valuable scientific input
for this project by Yuko Misumi, Jiannan Li, Hisako Kubota-Kawai, Takeshi Kawabata,
Mian Wu, Eiki Yamashita, Atsushi Nakagawa, Volker Hartmann, Melanie Völkel and Matthias
Rögner. Parts of this research were funded by the German Research Council (DFG)
within the framework of GRK 2341 (Microbial Substrate Conversion) to M.M.N., the
Platform Project for Supporting Drug Discovery and Life Science Research [Basis
for Supporting Innovative Drug Discovery and Life Science Research (BINDS)] from
AMED under grant number JP20am0101117 (K.N.), JP16K07266 to Atsunori Oshima and
C.G., a Grants-in-Aid for Scientific Research under grant number JP 25000013 (K.N.),
17H03647 (C.G.) and 16H06560 (G.K.) from MEXT-KAKENHI, the International Joint Research
Promotion Program from Osaka University to M.M.N., C.G. and G.K., and the Cyclic
Innovation for Clinical Empowerment (CiCLE) Grant Number JP17pc0101020 from AMED
to K.N. and G.K.
article_number: '304'
article_processing_charge: No
article_type: original
author:
- first_name: Mehmet Orkun
full_name: Çoruh, Mehmet Orkun
id: d25163e5-8d53-11eb-a251-e6dd8ea1b8ef
last_name: Çoruh
orcid: 0000-0002-3219-2022
- first_name: Anna
full_name: Frank, Anna
last_name: Frank
- first_name: Hideaki
full_name: Tanaka, Hideaki
last_name: Tanaka
- first_name: Akihiro
full_name: Kawamoto, Akihiro
last_name: Kawamoto
- first_name: Eithar
full_name: El-Mohsnawy, Eithar
last_name: El-Mohsnawy
- first_name: Takayuki
full_name: Kato, Takayuki
last_name: Kato
- first_name: Keiichi
full_name: Namba, Keiichi
last_name: Namba
- first_name: Christoph
full_name: Gerle, Christoph
last_name: Gerle
- first_name: Marc M.
full_name: Nowaczyk, Marc M.
last_name: Nowaczyk
- first_name: Genji
full_name: Kurisu, Genji
last_name: Kurisu
citation:
ama: Çoruh MO, Frank A, Tanaka H, et al. Cryo-EM structure of a functional monomeric
Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster.
Communications Biology. 2021;4(1). doi:10.1038/s42003-021-01808-9
apa: Çoruh, M. O., Frank, A., Tanaka, H., Kawamoto, A., El-Mohsnawy, E., Kato, T.,
… Kurisu, G. (2021). Cryo-EM structure of a functional monomeric Photosystem I
from Thermosynechococcus elongatus reveals red chlorophyll cluster. Communications
Biology. Springer . https://doi.org/10.1038/s42003-021-01808-9
chicago: Çoruh, Mehmet Orkun, Anna Frank, Hideaki Tanaka, Akihiro Kawamoto, Eithar
El-Mohsnawy, Takayuki Kato, Keiichi Namba, Christoph Gerle, Marc M. Nowaczyk,
and Genji Kurisu. “Cryo-EM Structure of a Functional Monomeric Photosystem I from
Thermosynechococcus Elongatus Reveals Red Chlorophyll Cluster.” Communications
Biology. Springer , 2021. https://doi.org/10.1038/s42003-021-01808-9.
ieee: M. O. Çoruh et al., “Cryo-EM structure of a functional monomeric Photosystem
I from Thermosynechococcus elongatus reveals red chlorophyll cluster,” Communications
Biology, vol. 4, no. 1. Springer , 2021.
ista: Çoruh MO, Frank A, Tanaka H, Kawamoto A, El-Mohsnawy E, Kato T, Namba K, Gerle
C, Nowaczyk MM, Kurisu G. 2021. Cryo-EM structure of a functional monomeric Photosystem
I from Thermosynechococcus elongatus reveals red chlorophyll cluster. Communications
Biology. 4(1), 304.
mla: Çoruh, Mehmet Orkun, et al. “Cryo-EM Structure of a Functional Monomeric Photosystem
I from Thermosynechococcus Elongatus Reveals Red Chlorophyll Cluster.” Communications
Biology, vol. 4, no. 1, 304, Springer , 2021, doi:10.1038/s42003-021-01808-9.
short: M.O. Çoruh, A. Frank, H. Tanaka, A. Kawamoto, E. El-Mohsnawy, T. Kato, K.
Namba, C. Gerle, M.M. Nowaczyk, G. Kurisu, Communications Biology 4 (2021).
date_created: 2021-11-19T11:37:29Z
date_published: 2021-03-08T00:00:00Z
date_updated: 2023-08-14T11:51:19Z
day: '08'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1038/s42003-021-01808-9
external_id:
isi:
- '000627440700001'
pmid:
- '33686186'
file:
- access_level: open_access
checksum: 8ffd39f2bba7152a2441802ff313bf0b
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-19T15:09:18Z
date_updated: 2021-11-19T15:09:18Z
file_id: '10318'
file_name: 2021_CommBio_Çoruh.pdf
file_size: 6030261
relation: main_file
success: 1
file_date_updated: 2021-11-19T15:09:18Z
has_accepted_license: '1'
intvolume: ' 4'
isi: 1
issue: '1'
keyword:
- general agricultural and biological Sciences
- general biochemistry
- genetics and molecular biology
- medicine (miscellaneous)
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Communications Biology
publication_identifier:
issn:
- 2399-3642
publication_status: published
publisher: 'Springer '
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus
elongatus reveals red chlorophyll cluster
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 4
year: '2021'
...
---
_id: '10270'
abstract:
- lang: eng
text: Plants develop new organs to adjust their bodies to dynamic changes in the
environment. How independent organs achieve anisotropic shapes and polarities
is poorly understood. To address this question, we constructed a mechano-biochemical
model for Arabidopsis root meristem growth that integrates biologically plausible
principles. Computer model simulations demonstrate how differential growth of
neighboring tissues results in the initial symmetry-breaking leading to anisotropic
root growth. Furthermore, the root growth feeds back on a polar transport network
of the growth regulator auxin. Model, predictions are in close agreement with
in vivo patterns of anisotropic growth, auxin distribution, and cell polarity,
as well as several root phenotypes caused by chemical, mechanical, or genetic
perturbations. Our study demonstrates that the combination of tissue mechanics
and polar auxin transport organizes anisotropic root growth and cell polarities
during organ outgrowth. Therefore, a mobile auxin signal transported through immobile
cells drives polarity and growth mechanics to coordinate complex organ development.
acknowledgement: 'e are grateful Richard Smith, Anne-Lise Routier, Crisanto Gutierrez
and Juergen Kleine-Vehn for providing critical comments on the manuscript. Funding:
This work was supported by the Programa de Atraccion de Talento 2017 (Comunidad
de Madrid, 2017-T1/BIO-5654 to KW), Severo Ochoa (SO) Programme for Centres of Excellence
in R&D from the Agencia Estatal de Investigacion of Spain (grant SEV-2016–0672 (2017–2021)
to KW via the CBGP). In the frame of SEV-2016–0672 funding MM is supported with
a postdoctoral contract. KW was supported by Programa Estatal de Generacion del
Conocimiento y Fortalecimiento Cientıfico y Tecnologico del Sistema de I + D + I
2019 (PGC2018-093387-A-I00) from MICIU (to KW). MG is recipient of an IST Interdisciplinary
Project (IC1022IPC03).'
article_number: '72132'
article_processing_charge: Yes
article_type: original
author:
- first_name: Marco
full_name: Marconi, Marco
last_name: Marconi
- first_name: Marçal
full_name: Gallemi, Marçal
id: 460C6802-F248-11E8-B48F-1D18A9856A87
last_name: Gallemi
orcid: 0000-0003-4675-6893
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Krzysztof
full_name: Wabnik, Krzysztof
last_name: Wabnik
citation:
ama: Marconi M, Gallemi M, Benková E, Wabnik K. A coupled mechano-biochemical model
for cell polarity guided anisotropic root growth. eLife. 2021;10. doi:10.7554/elife.72132
apa: Marconi, M., Gallemi, M., Benková, E., & Wabnik, K. (2021). A coupled mechano-biochemical
model for cell polarity guided anisotropic root growth. ELife. eLife Sciences
Publications. https://doi.org/10.7554/elife.72132
chicago: Marconi, Marco, Marçal Gallemi, Eva Benková, and Krzysztof Wabnik. “A Coupled
Mechano-Biochemical Model for Cell Polarity Guided Anisotropic Root Growth.” ELife.
eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.72132.
ieee: M. Marconi, M. Gallemi, E. Benková, and K. Wabnik, “A coupled mechano-biochemical
model for cell polarity guided anisotropic root growth,” eLife, vol. 10.
eLife Sciences Publications, 2021.
ista: Marconi M, Gallemi M, Benková E, Wabnik K. 2021. A coupled mechano-biochemical
model for cell polarity guided anisotropic root growth. eLife. 10, 72132.
mla: Marconi, Marco, et al. “A Coupled Mechano-Biochemical Model for Cell Polarity
Guided Anisotropic Root Growth.” ELife, vol. 10, 72132, eLife Sciences
Publications, 2021, doi:10.7554/elife.72132.
short: M. Marconi, M. Gallemi, E. Benková, K. Wabnik, ELife 10 (2021).
date_created: 2021-11-11T10:05:18Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2023-08-14T11:49:23Z
day: '01'
ddc:
- '570'
department:
- _id: EvBe
doi: 10.7554/elife.72132
external_id:
isi:
- '000734671200001'
pmid:
- '34723798'
file:
- access_level: open_access
checksum: fad13c509b53bb7a2bef9c946a7ca60a
content_type: application/pdf
creator: dernst
date_created: 2022-05-13T09:00:29Z
date_updated: 2022-05-13T09:00:29Z
file_id: '11372'
file_name: 2021_eLife_Marconi.pdf
file_size: 14137503
relation: main_file
success: 1
file_date_updated: 2022-05-13T09:00:29Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: A coupled mechano-biochemical model for cell polarity guided anisotropic root
growth
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '10299'
abstract:
- lang: eng
text: Turbulence generally arises in shear flows if velocities and hence, inertial
forces are sufficiently large. In striking contrast, viscoelastic fluids can exhibit
disordered motion even at vanishing inertia. Intermediate between these cases,
a state of chaotic motion, “elastoinertial turbulence” (EIT), has been observed
in a narrow Reynolds number interval. We here determine the origin of EIT in experiments
and show that characteristic EIT structures can be detected across an unexpectedly
wide range of parameters. Close to onset, a pattern of chevron-shaped streaks
emerges in qualitative agreement with linear and weakly nonlinear theory. However,
in experiments, the dynamics remain weakly chaotic, and the instability can be
traced to far lower Reynolds numbers than permitted by theory. For increasing
inertia, the flow undergoes a transformation to a wall mode composed of inclined
near-wall streaks and shear layers. This mode persists to what is known as the
“maximum drag reduction limit,” and overall EIT is found to dominate viscoelastic
flows across more than three orders of magnitude in Reynolds number.
acknowledgement: We thank Y. Dubief, R. Kerswell, E. Marensi, V. Shankar, V. Steinberg,
and V. Terrapon for discussions and helpful comments. A.V. and B.H. acknowledge
funding from the Austrian Science Fund, grant I4188-N30, within the Deutsche Forschungsgemeinschaft
research unit FOR 2688.
article_number: e2102350118
article_processing_charge: No
article_type: original
author:
- first_name: George H
full_name: Choueiri, George H
id: 448BD5BC-F248-11E8-B48F-1D18A9856A87
last_name: Choueiri
- first_name: Jose M
full_name: Lopez Alonso, Jose M
id: 40770848-F248-11E8-B48F-1D18A9856A87
last_name: Lopez Alonso
orcid: 0000-0002-0384-2022
- first_name: Atul
full_name: Varshney, Atul
id: 2A2006B2-F248-11E8-B48F-1D18A9856A87
last_name: Varshney
orcid: 0000-0002-3072-5999
- first_name: Sarath
full_name: Sankar, Sarath
last_name: Sankar
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Choueiri GH, Lopez Alonso JM, Varshney A, Sankar S, Hof B. Experimental observation
of the origin and structure of elastoinertial turbulence. Proceedings of the
National Academy of Sciences. 2021;118(45). doi:10.1073/pnas.2102350118
apa: Choueiri, G. H., Lopez Alonso, J. M., Varshney, A., Sankar, S., & Hof,
B. (2021). Experimental observation of the origin and structure of elastoinertial
turbulence. Proceedings of the National Academy of Sciences. National Academy
of Sciences. https://doi.org/10.1073/pnas.2102350118
chicago: Choueiri, George H, Jose M Lopez Alonso, Atul Varshney, Sarath Sankar,
and Björn Hof. “Experimental Observation of the Origin and Structure of Elastoinertial
Turbulence.” Proceedings of the National Academy of Sciences. National
Academy of Sciences, 2021. https://doi.org/10.1073/pnas.2102350118.
ieee: G. H. Choueiri, J. M. Lopez Alonso, A. Varshney, S. Sankar, and B. Hof, “Experimental
observation of the origin and structure of elastoinertial turbulence,” Proceedings
of the National Academy of Sciences, vol. 118, no. 45. National Academy of
Sciences, 2021.
ista: Choueiri GH, Lopez Alonso JM, Varshney A, Sankar S, Hof B. 2021. Experimental
observation of the origin and structure of elastoinertial turbulence. Proceedings
of the National Academy of Sciences. 118(45), e2102350118.
mla: Choueiri, George H., et al. “Experimental Observation of the Origin and Structure
of Elastoinertial Turbulence.” Proceedings of the National Academy of Sciences,
vol. 118, no. 45, e2102350118, National Academy of Sciences, 2021, doi:10.1073/pnas.2102350118.
short: G.H. Choueiri, J.M. Lopez Alonso, A. Varshney, S. Sankar, B. Hof, Proceedings
of the National Academy of Sciences 118 (2021).
date_created: 2021-11-17T13:24:24Z
date_published: 2021-11-03T00:00:00Z
date_updated: 2023-08-14T11:50:10Z
day: '03'
department:
- _id: BjHo
doi: 10.1073/pnas.2102350118
external_id:
arxiv:
- '2103.00023'
isi:
- '000720926900019'
pmid:
- ' 34732570'
intvolume: ' 118'
isi: 1
issue: '45'
keyword:
- multidisciplinary
- elastoinertial turbulence
- viscoelastic flows
- elastic instability
- drag reduction
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2103.00023
month: '11'
oa: 1
oa_version: Preprint
pmid: 1
project:
- _id: 238B8092-32DE-11EA-91FC-C7463DDC885E
call_identifier: FWF
grant_number: I04188
name: Instabilities in pulsating pipe flow of Newtonian and complex fluids
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Experimental observation of the origin and structure of elastoinertial turbulence
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 118
year: '2021'
...
---
_id: '10280'
abstract:
- lang: eng
text: 'Machines enabled the Industrial Revolution and are central to modern technological
progress: A machine’s parts transmit forces, motion, and energy to one another
in a predetermined manner. Today’s engineering frontier, building artificial micromachines
that emulate the biological machinery of living organisms, requires faithful assembly
and energy consumption at the microscale. Here, we demonstrate the programmable
assembly of active particles into autonomous metamachines using optical templates.
Metamachines, or machines made of machines, are stable, mobile and autonomous
architectures, whose dynamics stems from the geometry. We use the interplay between
anisotropic force generation of the active colloids with the control of their
orientation by local geometry. This allows autonomous reprogramming of active
particles of the metamachines to achieve multiple functions. It permits the modular
assembly of metamachines by fusion, reconfiguration of metamachines and, we anticipate,
a shift in focus of self-assembly towards active matter and reprogrammable materials.'
acknowledgement: The authors thank R. Jazzar for useful advice regarding the synthesis
of heterodimers. We thank S. Sacanna for critical reading. This material is based
upon work supported by the National Science Foundation under Grant No. DMR-1554724
and Department of Army Research under grant W911NF-20-1-0112.
article_number: '6398'
article_processing_charge: Yes
article_type: original
author:
- first_name: Antoine
full_name: Aubret, Antoine
last_name: Aubret
- first_name: Quentin
full_name: Martinet, Quentin
id: b37485a8-d343-11eb-a0e9-df8c484ef8ab
last_name: Martinet
orcid: 0000-0002-2916-6632
- first_name: Jérémie A
full_name: Palacci, Jérémie A
id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d
last_name: Palacci
orcid: 0000-0002-7253-9465
citation:
ama: Aubret A, Martinet Q, Palacci JA. Metamachines of pluripotent colloids. Nature
Communications. 2021;12(1). doi:10.1038/s41467-021-26699-6
apa: Aubret, A., Martinet, Q., & Palacci, J. A. (2021). Metamachines of pluripotent
colloids. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-021-26699-6
chicago: Aubret, Antoine, Quentin Martinet, and Jérémie A Palacci. “Metamachines
of Pluripotent Colloids.” Nature Communications. Springer Nature, 2021.
https://doi.org/10.1038/s41467-021-26699-6.
ieee: A. Aubret, Q. Martinet, and J. A. Palacci, “Metamachines of pluripotent colloids,”
Nature Communications, vol. 12, no. 1. Springer Nature, 2021.
ista: Aubret A, Martinet Q, Palacci JA. 2021. Metamachines of pluripotent colloids.
Nature Communications. 12(1), 6398.
mla: Aubret, Antoine, et al. “Metamachines of Pluripotent Colloids.” Nature Communications,
vol. 12, no. 1, 6398, Springer Nature, 2021, doi:10.1038/s41467-021-26699-6.
short: A. Aubret, Q. Martinet, J.A. Palacci, Nature Communications 12 (2021).
date_created: 2021-11-14T23:01:23Z
date_published: 2021-11-04T00:00:00Z
date_updated: 2023-08-14T11:48:37Z
day: '04'
ddc:
- '530'
department:
- _id: JePa
doi: 10.1038/s41467-021-26699-6
external_id:
isi:
- '000714754400010'
pmid:
- '34737315'
file:
- access_level: open_access
checksum: 1c392b12b9b7b615d422d9fabe19cdb9
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-15T13:25:52Z
date_updated: 2021-11-15T13:25:52Z
file_id: '10292'
file_name: 2021_NatComm_Aubret.pdf
file_size: 6282703
relation: main_file
success: 1
file_date_updated: 2021-11-15T13:25:52Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Metamachines of pluripotent colloids
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2021'
...
---
_id: '10322'
abstract:
- lang: eng
text: To survive elevated temperatures, ectotherms adjust the fluidity of membranes
by fine-tuning lipid desaturation levels in a process previously described to
be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal
heat shock factor 1 (HSF-1), the conserved master regulator of the heat shock
response (HSR), causes extensive fat remodeling in peripheral tissues. These changes
include a decrease in fat desaturase and acid lipase expression in the intestine
and a global shift in the saturation levels of plasma membrane’s phospholipids.
The observed remodeling of plasma membrane is in line with ectothermic adaptive
responses and gives worms a cumulative advantage to warm temperatures. We have
determined that at least 6 TAX-2/TAX-4 cyclic guanosine monophosphate (cGMP) gated
channel expressing sensory neurons, and transforming growth factor ß (TGF-β)/bone
morphogenetic protein (BMP) are required for signaling across tissues to modulate
fat desaturation. We also find neuronal hsf-1 is not only sufficient but also
partially necessary to control the fat remodeling response and for survival at
warm temperatures. This is the first study to show that a thermostat-based mechanism
can cell nonautonomously coordinate membrane saturation and composition across
tissues in a multicellular animal.
acknowledgement: We dedicate this work to the memory of Michael J.O. Wakelam. We would
like to acknowledge Michael Fasseas (Invermis, Magnitude Biosciences) for plasmid
injections and Sunny Biotech for transgenics; Catalina Vallejos and John Marioni
for statistical advice at the beginning of the work; Simon Walker, Imaging, Bioinformatics
and Lipidomics Facilities at Babraham Institute for technical support; and Cindy
Voisine, Michael Witting, Jon Houseley, Len Stephens, Carmen Nussbaum Krammer, Rebeca
Aldunate, Patricija van Oosten-Hawle, Jean-Louis Bessereau, and Jane Alfred for
feedback on the manuscript. We thank Andy Dillin, Atsushi Kuhara, Amy Walker, Andrew
Leifer, Yun Zhang, and Michalis Barkoulas for reagents and Julie Ahringer, Anne
Ferguson-Smith, and Anne Corcoran for support and helpful discussions. We also acknowledge
Babraham Institute Facilities.
article_number: e3001431
article_processing_charge: No
article_type: original
author:
- first_name: Laetitia
full_name: Chauve, Laetitia
last_name: Chauve
- first_name: Francesca
full_name: Hodge, Francesca
last_name: Hodge
- first_name: Sharlene
full_name: Murdoch, Sharlene
last_name: Murdoch
- first_name: Fatemah
full_name: Masoudzadeh, Fatemah
last_name: Masoudzadeh
- first_name: Harry Jack
full_name: Mann, Harry Jack
last_name: Mann
- first_name: Andrea
full_name: Lopez-Clavijo, Andrea
last_name: Lopez-Clavijo
- first_name: Hanneke
full_name: Okkenhaug, Hanneke
last_name: Okkenhaug
- first_name: Greg
full_name: West, Greg
last_name: West
- first_name: Bebiana C.
full_name: Sousa, Bebiana C.
last_name: Sousa
- first_name: Anne
full_name: Segonds-Pichon, Anne
last_name: Segonds-Pichon
- first_name: Cheryl
full_name: Li, Cheryl
last_name: Li
- first_name: Steven
full_name: Wingett, Steven
last_name: Wingett
- first_name: Hermine
full_name: Kienberger, Hermine
last_name: Kienberger
- first_name: Karin
full_name: Kleigrewe, Karin
last_name: Kleigrewe
- first_name: Mario
full_name: De Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: De Bono
orcid: 0000-0001-8347-0443
- first_name: Michael
full_name: Wakelam, Michael
last_name: Wakelam
- first_name: Olivia
full_name: Casanueva, Olivia
last_name: Casanueva
citation:
ama: Chauve L, Hodge F, Murdoch S, et al. Neuronal HSF-1 coordinates the propagation
of fat desaturation across tissues to enable adaptation to high temperatures in
C. elegans. PLoS Biology. 2021;19(11). doi:10.1371/journal.pbio.3001431
apa: Chauve, L., Hodge, F., Murdoch, S., Masoudzadeh, F., Mann, H. J., Lopez-Clavijo,
A., … Casanueva, O. (2021). Neuronal HSF-1 coordinates the propagation of fat
desaturation across tissues to enable adaptation to high temperatures in C. elegans.
PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.3001431
chicago: Chauve, Laetitia, Francesca Hodge, Sharlene Murdoch, Fatemah Masoudzadeh,
Harry Jack Mann, Andrea Lopez-Clavijo, Hanneke Okkenhaug, et al. “Neuronal HSF-1
Coordinates the Propagation of Fat Desaturation across Tissues to Enable Adaptation
to High Temperatures in C. Elegans.” PLoS Biology. Public Library of Science,
2021. https://doi.org/10.1371/journal.pbio.3001431.
ieee: L. Chauve et al., “Neuronal HSF-1 coordinates the propagation of fat
desaturation across tissues to enable adaptation to high temperatures in C. elegans,”
PLoS Biology, vol. 19, no. 11. Public Library of Science, 2021.
ista: Chauve L, Hodge F, Murdoch S, Masoudzadeh F, Mann HJ, Lopez-Clavijo A, Okkenhaug
H, West G, Sousa BC, Segonds-Pichon A, Li C, Wingett S, Kienberger H, Kleigrewe
K, de Bono M, Wakelam M, Casanueva O. 2021. Neuronal HSF-1 coordinates the propagation
of fat desaturation across tissues to enable adaptation to high temperatures in
C. elegans. PLoS Biology. 19(11), e3001431.
mla: Chauve, Laetitia, et al. “Neuronal HSF-1 Coordinates the Propagation of Fat
Desaturation across Tissues to Enable Adaptation to High Temperatures in C. Elegans.”
PLoS Biology, vol. 19, no. 11, e3001431, Public Library of Science, 2021,
doi:10.1371/journal.pbio.3001431.
short: L. Chauve, F. Hodge, S. Murdoch, F. Masoudzadeh, H.J. Mann, A. Lopez-Clavijo,
H. Okkenhaug, G. West, B.C. Sousa, A. Segonds-Pichon, C. Li, S. Wingett, H. Kienberger,
K. Kleigrewe, M. de Bono, M. Wakelam, O. Casanueva, PLoS Biology 19 (2021).
date_created: 2021-11-21T23:01:28Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2023-08-14T11:53:27Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1371/journal.pbio.3001431
external_id:
isi:
- '000715818400001'
pmid:
- '34723964'
file:
- access_level: open_access
checksum: 0c61b667f814fd9435b3ac42036fc36d
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-22T09:34:03Z
date_updated: 2021-11-22T09:34:03Z
file_id: '10330'
file_name: 2021_PLoSBio_Chauve.pdf
file_size: 4069215
relation: main_file
success: 1
file_date_updated: 2021-11-22T09:34:03Z
has_accepted_license: '1'
intvolume: ' 19'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLoS Biology
publication_identifier:
eissn:
- 1545-7885
issn:
- 1544-9173
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
record:
- id: '13069'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues
to enable adaptation to high temperatures in C. elegans
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 19
year: '2021'
...
---
_id: '10222'
abstract:
- lang: eng
text: Consider a random set of points on the unit sphere in ℝd, which can be either
uniformly sampled or a Poisson point process. Its convex hull is a random inscribed
polytope, whose boundary approximates the sphere. We focus on the case d = 3,
for which there are elementary proofs and fascinating formulas for metric properties.
In particular, we study the fraction of acute facets, the expected intrinsic volumes,
the total edge length, and the distance to a fixed point. Finally we generalize
the results to the ellipsoid with homeoid density.
acknowledgement: "This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme,
grant no. 788183, from the Wittgenstein Prize, Austrian Science Fund (FWF), grant
no. Z 342-N31, and from the DFG Collaborative Research Center TRR 109, ‘Discretization
in Geometry and Dynamics’, Austrian Science Fund (FWF), grant no. I 02979-N35.\r\nWe
are grateful to Dmitry Zaporozhets and Christoph Thäle for valuable comments and
for directing us to relevant references. We also thank to Anton Mellit for a useful
discussion on Bessel functions."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Arseniy
full_name: Akopyan, Arseniy
id: 430D2C90-F248-11E8-B48F-1D18A9856A87
last_name: Akopyan
orcid: 0000-0002-2548-617X
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Anton
full_name: Nikitenko, Anton
id: 3E4FF1BA-F248-11E8-B48F-1D18A9856A87
last_name: Nikitenko
orcid: 0000-0002-0659-3201
citation:
ama: Akopyan A, Edelsbrunner H, Nikitenko A. The beauty of random polytopes inscribed
in the 2-sphere. Experimental Mathematics. 2021:1-15. doi:10.1080/10586458.2021.1980459
apa: Akopyan, A., Edelsbrunner, H., & Nikitenko, A. (2021). The beauty of random
polytopes inscribed in the 2-sphere. Experimental Mathematics. Taylor and
Francis. https://doi.org/10.1080/10586458.2021.1980459
chicago: Akopyan, Arseniy, Herbert Edelsbrunner, and Anton Nikitenko. “The Beauty
of Random Polytopes Inscribed in the 2-Sphere.” Experimental Mathematics.
Taylor and Francis, 2021. https://doi.org/10.1080/10586458.2021.1980459.
ieee: A. Akopyan, H. Edelsbrunner, and A. Nikitenko, “The beauty of random polytopes
inscribed in the 2-sphere,” Experimental Mathematics. Taylor and Francis,
pp. 1–15, 2021.
ista: Akopyan A, Edelsbrunner H, Nikitenko A. 2021. The beauty of random polytopes
inscribed in the 2-sphere. Experimental Mathematics., 1–15.
mla: Akopyan, Arseniy, et al. “The Beauty of Random Polytopes Inscribed in the 2-Sphere.”
Experimental Mathematics, Taylor and Francis, 2021, pp. 1–15, doi:10.1080/10586458.2021.1980459.
short: A. Akopyan, H. Edelsbrunner, A. Nikitenko, Experimental Mathematics (2021)
1–15.
date_created: 2021-11-07T23:01:25Z
date_published: 2021-10-25T00:00:00Z
date_updated: 2023-08-14T11:57:07Z
day: '25'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1080/10586458.2021.1980459
ec_funded: 1
external_id:
arxiv:
- '2007.07783'
isi:
- '000710893500001'
file:
- access_level: open_access
checksum: 3514382e3a1eb87fa6c61ad622874415
content_type: application/pdf
creator: dernst
date_created: 2023-08-14T11:55:10Z
date_updated: 2023-08-14T11:55:10Z
file_id: '14053'
file_name: 2023_ExperimentalMath_Akopyan.pdf
file_size: 1966019
relation: main_file
success: 1
file_date_updated: 2023-08-14T11:55:10Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 1-15
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
- _id: 268116B8-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00342
name: The Wittgenstein Prize
- _id: 0aa4bc98-070f-11eb-9043-e6fff9c6a316
grant_number: I4887
name: Discretization in Geometry and Dynamics
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I02979-N35
name: Persistence and stability of geometric complexes
publication: Experimental Mathematics
publication_identifier:
eissn:
- 1944-950X
issn:
- 1058-6458
publication_status: published
publisher: Taylor and Francis
quality_controlled: '1'
scopus_import: '1'
status: public
title: The beauty of random polytopes inscribed in the 2-sphere
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '10323'
abstract:
- lang: eng
text: Molecular chaperones are central to cellular protein homeostasis. Dynamic
disorder is a key feature of the complexes of molecular chaperones and their client
proteins, and it facilitates the client release towards a folded state or the
handover to downstream components. The dynamic nature also implies that a given
chaperone can interact with many different client proteins, based on physico-chemical
sequence properties rather than on structural complementarity of their (folded)
3D structure. Yet, the balance between this promiscuity and some degree of client
specificity is poorly understood. Here, we review recent atomic-level descriptions
of chaperones with client proteins, including chaperones in complex with intrinsically
disordered proteins, with membrane-protein precursors, or partially folded client
proteins. We focus hereby on chaperone-client interactions that are independent
of ATP. The picture emerging from these studies highlights the importance of dynamics
in these complexes, whereby several interaction types, not only hydrophobic ones,
contribute to the complex formation. We discuss these features of chaperone-client
complexes and possible factors that may contribute to this balance of promiscuity
and specificity.
acknowledgement: We thank Juan C. Fontecilla-Camps for insightful discussions related
to ATP-driven machineries, and Elif Karagöz for providing the structural model of
the Hsp90-Tau complex. This study was supported by the European Research Council
(StG-2012-311318-ProtDyn2Function) and the Agence Nationale de la Recherche (ANR-18-CE92-0032-MitoMemProtImp).
article_number: '762005'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Iva
full_name: Sučec, Iva
last_name: Sučec
- first_name: Beate
full_name: Bersch, Beate
last_name: Bersch
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Sučec I, Bersch B, Schanda P. How do chaperones bind (partly) unfolded client
proteins? Frontiers in Molecular Biosciences. 2021;8. doi:10.3389/fmolb.2021.762005
apa: Sučec, I., Bersch, B., & Schanda, P. (2021). How do chaperones bind (partly)
unfolded client proteins? Frontiers in Molecular Biosciences. Frontiers.
https://doi.org/10.3389/fmolb.2021.762005
chicago: Sučec, Iva, Beate Bersch, and Paul Schanda. “How Do Chaperones Bind (Partly)
Unfolded Client Proteins?” Frontiers in Molecular Biosciences. Frontiers,
2021. https://doi.org/10.3389/fmolb.2021.762005.
ieee: I. Sučec, B. Bersch, and P. Schanda, “How do chaperones bind (partly) unfolded
client proteins?,” Frontiers in Molecular Biosciences, vol. 8. Frontiers,
2021.
ista: Sučec I, Bersch B, Schanda P. 2021. How do chaperones bind (partly) unfolded
client proteins? Frontiers in Molecular Biosciences. 8, 762005.
mla: Sučec, Iva, et al. “How Do Chaperones Bind (Partly) Unfolded Client Proteins?”
Frontiers in Molecular Biosciences, vol. 8, 762005, Frontiers, 2021, doi:10.3389/fmolb.2021.762005.
short: I. Sučec, B. Bersch, P. Schanda, Frontiers in Molecular Biosciences 8 (2021).
date_created: 2021-11-21T23:01:29Z
date_published: 2021-10-25T00:00:00Z
date_updated: 2023-08-14T11:55:04Z
day: '25'
ddc:
- '547'
department:
- _id: PaSc
doi: 10.3389/fmolb.2021.762005
external_id:
isi:
- '000717241700001'
pmid:
- '34760928'
file:
- access_level: open_access
checksum: a5c9dbf80dc2c5aaa737f456c941d964
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-23T15:06:58Z
date_updated: 2021-11-23T15:06:58Z
file_id: '10333'
file_name: 2021_FrontiersMolBioSc_Sučec.pdf
file_size: 4700798
relation: main_file
success: 1
file_date_updated: 2021-11-23T15:06:58Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Molecular Biosciences
publication_identifier:
eissn:
- 2296-889X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: How do chaperones bind (partly) unfolded client proteins?
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 8
year: '2021'
...
---
_id: '10326'
abstract:
- lang: eng
text: Strigolactones (SLs) are carotenoid-derived plant hormones that control shoot
branching and communications between host plants and symbiotic fungi or root parasitic
plants. Extensive studies have identified the key components participating in
SL biosynthesis and signalling, whereas the catabolism or deactivation of endogenous
SLs in planta remains largely unknown. Here, we report that the Arabidopsis carboxylesterase
15 (AtCXE15) and its orthologues function as efficient hydrolases of SLs. We show
that overexpression of AtCXE15 promotes shoot branching by dampening SL-inhibited
axillary bud outgrowth. We further demonstrate that AtCXE15 could bind and efficiently
hydrolyse SLs both in vitro and in planta. We also provide evidence that AtCXE15
is capable of catalysing hydrolysis of diverse SL analogues and that such CXE15-dependent
catabolism of SLs is evolutionarily conserved in seed plants. These results disclose
a catalytic mechanism underlying homoeostatic regulation of SLs in plants, which
also provides a rational approach to spatial-temporally manipulate the endogenous
SLs and thus architecture of crops and ornamental plants.
acknowledgement: We thank J. Li (Institute of Genetics and Developmental Biology,
China) for providing the at14-1, atmax2-1, atmax3-9, atmax4-1, atmax1-1, kai2-2
(Col-0 background) mutants and B. Xu for providing the complementary DNA of P. patens.
We are grateful to L. Wang for assistance with MST, B. Han for assistance with UPLC–MS,
J. Li for assistance with confocal microscopy and B. Mikael and J. Zhang for their
comments on the manuscript. This work was supported by grants from Strategic Priority
Research Program of Chinese Academy of Sciences (Y.H., XDB27030102) and the National
Natural Science Foundation of China (E.X., 31700253; Y.H., 31830055).
article_processing_charge: No
article_type: original
author:
- first_name: Enjun
full_name: Xu, Enjun
last_name: Xu
- first_name: Liang
full_name: Chai, Liang
last_name: Chai
- first_name: Shiqi
full_name: Zhang, Shiqi
last_name: Zhang
- first_name: Ruixue
full_name: Yu, Ruixue
last_name: Yu
- first_name: Xixi
full_name: Zhang, Xixi
id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
last_name: Zhang
orcid: 0000-0001-7048-4627
- first_name: Chongyi
full_name: Xu, Chongyi
last_name: Xu
- first_name: Yuxin
full_name: Hu, Yuxin
last_name: Hu
citation:
ama: Xu E, Chai L, Zhang S, et al. Catabolism of strigolactones by a carboxylesterase.
Nature Plants. 2021;7:1495–1504. doi:10.1038/s41477-021-01011-y
apa: Xu, E., Chai, L., Zhang, S., Yu, R., Zhang, X., Xu, C., & Hu, Y. (2021).
Catabolism of strigolactones by a carboxylesterase. Nature Plants. Springer
Nature. https://doi.org/10.1038/s41477-021-01011-y
chicago: Xu, Enjun, Liang Chai, Shiqi Zhang, Ruixue Yu, Xixi Zhang, Chongyi Xu,
and Yuxin Hu. “Catabolism of Strigolactones by a Carboxylesterase.” Nature
Plants. Springer Nature, 2021. https://doi.org/10.1038/s41477-021-01011-y.
ieee: E. Xu et al., “Catabolism of strigolactones by a carboxylesterase,”
Nature Plants, vol. 7. Springer Nature, pp. 1495–1504, 2021.
ista: Xu E, Chai L, Zhang S, Yu R, Zhang X, Xu C, Hu Y. 2021. Catabolism of strigolactones
by a carboxylesterase. Nature Plants. 7, 1495–1504.
mla: Xu, Enjun, et al. “Catabolism of Strigolactones by a Carboxylesterase.” Nature
Plants, vol. 7, Springer Nature, 2021, pp. 1495–1504, doi:10.1038/s41477-021-01011-y.
short: E. Xu, L. Chai, S. Zhang, R. Yu, X. Zhang, C. Xu, Y. Hu, Nature Plants 7
(2021) 1495–1504.
date_created: 2021-11-21T23:01:30Z
date_published: 2021-11-11T00:00:00Z
date_updated: 2023-08-14T11:54:02Z
day: '11'
department:
- _id: JiFr
doi: 10.1038/s41477-021-01011-y
external_id:
isi:
- '000717408000002'
pmid:
- '34764442'
intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '11'
oa_version: None
page: '1495–1504 '
pmid: 1
publication: Nature Plants
publication_identifier:
eissn:
- 2055-0278
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Catabolism of strigolactones by a carboxylesterase
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 7
year: '2021'
...
---
_id: '13069'
abstract:
- lang: eng
text: To survive elevated temperatures, ectotherms adjust the fluidity of membranes
by fine-tuning lipid desaturation levels in a process previously described to
be cell-autonomous. We have discovered that, in Caenorhabditis elegans, neuronal
Heat shock Factor 1 (HSF-1), the conserved master regulator of the heat shock
response (HSR)- causes extensive fat remodelling in peripheral tissues. These
changes include a decrease in fat desaturase and acid lipase expression in the
intestine, and a global shift in the saturation levels of plasma membrane’s phospholipids.
The observed remodelling of plasma membrane is in line with ectothermic adaptive
responses and gives worms a cumulative advantage to warm temperatures. We have
determined that at least six TAX-2/TAX-4 cGMP gated channel expressing sensory
neurons and TGF-β/BMP are required for signalling across tissues to modulate fat
desaturation. We also find neuronal hsf-1 is not only sufficient but also partially
necessary to control the fat remodelling response and for survival at warm temperatures.
This is the first study to show that a thermostat-based mechanism can cell non-autonomously
coordinate membrane saturation and composition across tissues in a multicellular
animal.
article_processing_charge: No
author:
- first_name: Laetitia
full_name: Chauve, Laetitia
last_name: Chauve
- first_name: Francesca
full_name: Hodge, Francesca
last_name: Hodge
- first_name: Sharlene
full_name: Murdoch, Sharlene
last_name: Murdoch
- first_name: Fatemah
full_name: Masoudzadeh, Fatemah
last_name: Masoudzadeh
- first_name: Harry-Jack
full_name: Mann, Harry-Jack
last_name: Mann
- first_name: Andrea
full_name: Lopez-Clavijo, Andrea
last_name: Lopez-Clavijo
- first_name: Hanneke
full_name: Okkenhaug, Hanneke
last_name: Okkenhaug
- first_name: Greg
full_name: West, Greg
last_name: West
- first_name: Bebiana C.
full_name: Sousa, Bebiana C.
last_name: Sousa
- first_name: Anne
full_name: Segonds-Pichon, Anne
last_name: Segonds-Pichon
- first_name: Cheryl
full_name: Li, Cheryl
last_name: Li
- first_name: Steven
full_name: Wingett, Steven
last_name: Wingett
- first_name: Hermine
full_name: Kienberger, Hermine
last_name: Kienberger
- first_name: Karin
full_name: Kleigrewe, Karin
last_name: Kleigrewe
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: Michael
full_name: Wakelam, Michael
last_name: Wakelam
- first_name: Olivia
full_name: Casanueva, Olivia
last_name: Casanueva
citation:
ama: Chauve L, Hodge F, Murdoch S, et al. Neuronal HSF-1 coordinates the propagation
of fat desaturation across tissues to enable adaptation to high temperatures in
C. elegans. 2021. doi:10.5281/ZENODO.5519410
apa: Chauve, L., Hodge, F., Murdoch, S., Masoudzadeh, F., Mann, H.-J., Lopez-Clavijo,
A., … Casanueva, O. (2021). Neuronal HSF-1 coordinates the propagation of fat
desaturation across tissues to enable adaptation to high temperatures in C. elegans.
Zenodo. https://doi.org/10.5281/ZENODO.5519410
chicago: Chauve, Laetitia, Francesca Hodge, Sharlene Murdoch, Fatemah Masoudzadeh,
Harry-Jack Mann, Andrea Lopez-Clavijo, Hanneke Okkenhaug, et al. “Neuronal HSF-1
Coordinates the Propagation of Fat Desaturation across Tissues to Enable Adaptation
to High Temperatures in C. Elegans.” Zenodo, 2021. https://doi.org/10.5281/ZENODO.5519410.
ieee: L. Chauve et al., “Neuronal HSF-1 coordinates the propagation of fat
desaturation across tissues to enable adaptation to high temperatures in C. elegans.”
Zenodo, 2021.
ista: Chauve L, Hodge F, Murdoch S, Masoudzadeh F, Mann H-J, Lopez-Clavijo A, Okkenhaug
H, West G, Sousa BC, Segonds-Pichon A, Li C, Wingett S, Kienberger H, Kleigrewe
K, de Bono M, Wakelam M, Casanueva O. 2021. Neuronal HSF-1 coordinates the propagation
of fat desaturation across tissues to enable adaptation to high temperatures in
C. elegans, Zenodo, 10.5281/ZENODO.5519410.
mla: Chauve, Laetitia, et al. Neuronal HSF-1 Coordinates the Propagation of Fat
Desaturation across Tissues to Enable Adaptation to High Temperatures in C. Elegans.
Zenodo, 2021, doi:10.5281/ZENODO.5519410.
short: L. Chauve, F. Hodge, S. Murdoch, F. Masoudzadeh, H.-J. Mann, A. Lopez-Clavijo,
H. Okkenhaug, G. West, B.C. Sousa, A. Segonds-Pichon, C. Li, S. Wingett, H. Kienberger,
K. Kleigrewe, M. de Bono, M. Wakelam, O. Casanueva, (2021).
date_created: 2023-05-23T16:40:56Z
date_published: 2021-12-25T00:00:00Z
date_updated: 2023-08-14T11:53:26Z
day: '25'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.5281/ZENODO.5519410
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/zenodo.5547464
month: '12'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '10322'
relation: used_in_publication
status: public
status: public
title: Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues
to enable adaptation to high temperatures in C. elegans
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '10325'
abstract:
- lang: eng
text: Since the inception of Bitcoin, a plethora of distributed ledgers differing
in design and purpose has been created. While by design, blockchains provide no
means to securely communicate with external systems, numerous attempts towards
trustless cross-chain communication have been proposed over the years. Today,
cross-chain communication (CCC) plays a fundamental role in cryptocurrency exchanges,
scalability efforts via sharding, extension of existing systems through sidechains,
and bootstrapping of new blockchains. Unfortunately, existing proposals are designed
ad-hoc for specific use-cases, making it hard to gain confidence in their correctness
and composability. We provide the first systematic exposition of cross-chain communication
protocols. We formalize the underlying research problem and show that CCC is impossible
without a trusted third party, contrary to common beliefs in the blockchain community.
With this result in mind, we develop a framework to design new and evaluate existing
CCC protocols, focusing on the inherent trust assumptions thereof, and derive
a classification covering the field of cross-chain communication to date. We conclude
by discussing open challenges for CCC research and the implications of interoperability
on the security and privacy of blockchains.
acknowledgement: 'We would like express our gratitude to Georgia Avarikioti, Daniel
Perez and Dominik Harz for helpful comments and feedback on earlier versions of
this manuscript. We also thank Nicholas Stifter, Aljosha Judmayer, Philipp Schindler,
Edgar Weippl, and Alistair Stewart for insightful discussions during the early stages
of this research. We also wish to thank the anonymous reviewers for their valuable
comments that helped improve the presentation of our results. This research was
funded by Bridge 1 858561 SESC; Bridge 1 864738 PR4DLT (all FFG); the Christian
Doppler Laboratory for Security and Quality Improvement in the Production System
Lifecycle (CDL-SQI); the competence center SBA-K1 funded by COMET; Chaincode Labs
through the project SLN: Scalability for the Lightning Network; and by the Austrian
Science Fund (FWF) through the Meitner program (project M-2608). Mustafa Al-Bassam
is funded by a scholarship from the Alan Turing Institute. Alexei Zamyatin conducted
the early stages of this work during his time at SBA Research, and was supported
by a Binance Research Fellowship.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Alexei
full_name: Zamyatin, Alexei
last_name: Zamyatin
- first_name: Mustafa
full_name: Al-Bassam, Mustafa
last_name: Al-Bassam
- first_name: Dionysis
full_name: Zindros, Dionysis
last_name: Zindros
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Pedro
full_name: Moreno-Sanchez, Pedro
last_name: Moreno-Sanchez
- first_name: Aggelos
full_name: Kiayias, Aggelos
last_name: Kiayias
- first_name: William J.
full_name: Knottenbelt, William J.
last_name: Knottenbelt
citation:
ama: 'Zamyatin A, Al-Bassam M, Zindros D, et al. SoK: Communication across distributed
ledgers. In: 25th International Conference on Financial Cryptography and Data
Security. Vol 12675. Springer Nature; 2021:3-36. doi:10.1007/978-3-662-64331-0_1'
apa: 'Zamyatin, A., Al-Bassam, M., Zindros, D., Kokoris Kogias, E., Moreno-Sanchez,
P., Kiayias, A., & Knottenbelt, W. J. (2021). SoK: Communication across distributed
ledgers. In 25th International Conference on Financial Cryptography and Data
Security (Vol. 12675, pp. 3–36). Virtual: Springer Nature. https://doi.org/10.1007/978-3-662-64331-0_1'
chicago: 'Zamyatin, Alexei, Mustafa Al-Bassam, Dionysis Zindros, Eleftherios Kokoris
Kogias, Pedro Moreno-Sanchez, Aggelos Kiayias, and William J. Knottenbelt. “SoK:
Communication across Distributed Ledgers.” In 25th International Conference
on Financial Cryptography and Data Security, 12675:3–36. Springer Nature,
2021. https://doi.org/10.1007/978-3-662-64331-0_1.'
ieee: 'A. Zamyatin et al., “SoK: Communication across distributed ledgers,”
in 25th International Conference on Financial Cryptography and Data Security,
Virtual, 2021, vol. 12675, pp. 3–36.'
ista: 'Zamyatin A, Al-Bassam M, Zindros D, Kokoris Kogias E, Moreno-Sanchez P, Kiayias
A, Knottenbelt WJ. 2021. SoK: Communication across distributed ledgers. 25th International
Conference on Financial Cryptography and Data Security. FC: Financial Cryptography,
LNCS, vol. 12675, 3–36.'
mla: 'Zamyatin, Alexei, et al. “SoK: Communication across Distributed Ledgers.”
25th International Conference on Financial Cryptography and Data Security,
vol. 12675, Springer Nature, 2021, pp. 3–36, doi:10.1007/978-3-662-64331-0_1.'
short: A. Zamyatin, M. Al-Bassam, D. Zindros, E. Kokoris Kogias, P. Moreno-Sanchez,
A. Kiayias, W.J. Knottenbelt, in:, 25th International Conference on Financial
Cryptography and Data Security, Springer Nature, 2021, pp. 3–36.
conference:
end_date: 2021-03-05
location: Virtual
name: 'FC: Financial Cryptography'
start_date: 2021-03-01
date_created: 2021-11-21T23:01:29Z
date_published: 2021-10-23T00:00:00Z
date_updated: 2023-08-14T12:59:26Z
day: '23'
department:
- _id: ElKo
doi: 10.1007/978-3-662-64331-0_1
external_id:
isi:
- '000712016200001'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2019/1128
month: '10'
oa: 1
oa_version: Preprint
page: 3-36
publication: 25th International Conference on Financial Cryptography and Data Security
publication_identifier:
eisbn:
- 978-3-662-64331-0
eissn:
- 1611-3349
isbn:
- 9-783-6626-4330-3
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'SoK: Communication across distributed ledgers'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: '12675 '
year: '2021'
...
---
_id: '10324'
abstract:
- lang: eng
text: Off-chain protocols (channels) are a promising solution to the scalability
and privacy challenges of blockchain payments. Current proposals, however, require
synchrony assumptions to preserve the safety of a channel, leaking to an adversary
the exact amount of time needed to control the network for a successful attack.
In this paper, we introduce Brick, the first payment channel that remains secure
under network asynchrony and concurrently provides correct incentives. The core
idea is to incorporate the conflict resolution process within the channel by introducing
a rational committee of external parties, called wardens. Hence, if a party wants
to close a channel unilaterally, it can only get the committee’s approval for
the last valid state. Additionally, Brick provides sub-second latency because
it does not employ heavy-weight consensus. Instead, Brick uses consistent broadcast
to announce updates and close the channel, a light-weight abstraction that is
powerful enough to preserve safety and liveness to any rational parties. We formally
define and prove for Brick the properties a payment channel construction should
fulfill. We also design incentives for Brick such that honest and rational behavior
aligns. Finally, we provide a reference implementation of the smart contracts
in Solidity.
acknowledgement: We would like to thank Kaoutar Elkhiyaoui for her valuable feedback
as well as Jakub Sliwinski for his impactful contribution to this work.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Zeta
full_name: Avarikioti, Zeta
last_name: Avarikioti
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Roger
full_name: Wattenhofer, Roger
last_name: Wattenhofer
- first_name: Dionysis
full_name: Zindros, Dionysis
last_name: Zindros
citation:
ama: 'Avarikioti Z, Kokoris Kogias E, Wattenhofer R, Zindros D. Brick: Asynchronous
incentive-compatible payment channels. In: 25th International Conference on
Financial Cryptography and Data Security. Vol 12675. Springer Nature; 2021:209-230.
doi:10.1007/978-3-662-64331-0_11'
apa: 'Avarikioti, Z., Kokoris Kogias, E., Wattenhofer, R., & Zindros, D. (2021).
Brick: Asynchronous incentive-compatible payment channels. In 25th International
Conference on Financial Cryptography and Data Security (Vol. 12675, pp. 209–230).
Virtual: Springer Nature. https://doi.org/10.1007/978-3-662-64331-0_11'
chicago: 'Avarikioti, Zeta, Eleftherios Kokoris Kogias, Roger Wattenhofer, and Dionysis
Zindros. “Brick: Asynchronous Incentive-Compatible Payment Channels.” In 25th
International Conference on Financial Cryptography and Data Security, 12675:209–30.
Springer Nature, 2021. https://doi.org/10.1007/978-3-662-64331-0_11.'
ieee: 'Z. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, and D. Zindros, “Brick:
Asynchronous incentive-compatible payment channels,” in 25th International
Conference on Financial Cryptography and Data Security, Virtual, 2021, vol.
12675, pp. 209–230.'
ista: 'Avarikioti Z, Kokoris Kogias E, Wattenhofer R, Zindros D. 2021. Brick: Asynchronous
incentive-compatible payment channels. 25th International Conference on Financial
Cryptography and Data Security. FC: Financial Cryptography, LNCS, vol. 12675,
209–230.'
mla: 'Avarikioti, Zeta, et al. “Brick: Asynchronous Incentive-Compatible Payment
Channels.” 25th International Conference on Financial Cryptography and Data
Security, vol. 12675, Springer Nature, 2021, pp. 209–30, doi:10.1007/978-3-662-64331-0_11.'
short: Z. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, D. Zindros, in:, 25th International
Conference on Financial Cryptography and Data Security, Springer Nature, 2021,
pp. 209–230.
conference:
end_date: 2021-03-05
location: Virtual
name: 'FC: Financial Cryptography'
start_date: 2021-03-01
date_created: 2021-11-21T23:01:29Z
date_published: 2021-10-23T00:00:00Z
date_updated: 2023-08-14T12:59:58Z
day: '23'
department:
- _id: ElKo
doi: 10.1007/978-3-662-64331-0_11
external_id:
arxiv:
- '1905.11360'
isi:
- '000712016200011'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.11360
month: '10'
oa: 1
oa_version: Preprint
page: 209-230
publication: 25th International Conference on Financial Cryptography and Data Security
publication_identifier:
eisbn:
- 978-3-662-64331-0
eissn:
- 1611-3349
isbn:
- 9-783-6626-4330-3
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Brick: Asynchronous incentive-compatible payment channels'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: '12675 '
year: '2021'
...
---
_id: '10363'
abstract:
- lang: eng
text: Erythropoietin enhances oxygen delivery and reduces hypoxia-induced cell death,
but its pro-thrombotic activity is problematic for use of erythropoietin in treating
hypoxia. We constructed a fusion protein that stimulates red blood cell production
and neuroprotection without triggering platelet production, a marker for thrombosis.
The protein consists of an anti-glycophorin A nanobody and an erythropoietin mutant
(L108A). The mutation reduces activation of erythropoietin receptor homodimers
that induce erythropoiesis and thrombosis, but maintains the tissue-protective
signaling. The binding of the nanobody element to glycophorin A rescues homodimeric
erythropoietin receptor activation on red blood cell precursors. In a cell proliferation
assay, the fusion protein is active at 10−14 M, allowing an estimate of the number
of receptor–ligand complexes needed for signaling. This fusion protein stimulates
erythroid cell proliferation in vitro and in mice, and shows neuroprotective activity
in vitro. Our erythropoietin fusion protein presents a novel molecule for treating
hypoxia.
acknowledgement: This work was supported by funds from the Wyss Institute for Biologically
Inspired Engineering and the Boston Biomedical Innovation Center (Pilot Award 112475;
Drive Award U54HL119145). J.L., K.M.K., D.R.B., J.C.W. and P.A.S. were supported
by the Harvard Medical School Department of Systems Biology. J.C.W. was further
supported by the Harvard Medical School Laboratory of Systems Pharmacology. A.V.,
D.R.B. and P.A.S. were further supported by the Wyss Institute for Biologically
Inspired Engineering. N.G.G. was sponsored by the Army Research Office under Grant
Number W911NF-17-2-0092. The views and conclusions contained in this document are
those of the authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Office or the U.S. Government.
The U.S. Government is authorized to reproduce and distribute reprints for Government
purposes notwithstanding any copyright notation herein. We sincerely thank Amanda
Graveline and the Wyss Institute at Harvard for their scientific support.
article_number: gzab025
article_processing_charge: No
article_type: original
author:
- first_name: Jungmin
full_name: Lee, Jungmin
last_name: Lee
- first_name: Andyna
full_name: Vernet, Andyna
last_name: Vernet
- first_name: Nathalie
full_name: Gruber, Nathalie
id: 2C9C8316-AA17-11E9-B5C2-8BC2E5697425
last_name: Gruber
- first_name: Kasia M.
full_name: Kready, Kasia M.
last_name: Kready
- first_name: Devin R.
full_name: Burrill, Devin R.
last_name: Burrill
- first_name: Jeffrey C.
full_name: Way, Jeffrey C.
last_name: Way
- first_name: Pamela A.
full_name: Silver, Pamela A.
last_name: Silver
citation:
ama: Lee J, Vernet A, Gruber N, et al. Rational engineering of an erythropoietin
fusion protein to treat hypoxia. Protein Engineering, Design and Selection.
2021;34. doi:10.1093/protein/gzab025
apa: Lee, J., Vernet, A., Gruber, N., Kready, K. M., Burrill, D. R., Way, J. C.,
& Silver, P. A. (2021). Rational engineering of an erythropoietin fusion protein
to treat hypoxia. Protein Engineering, Design and Selection. Oxford University
Press. https://doi.org/10.1093/protein/gzab025
chicago: Lee, Jungmin, Andyna Vernet, Nathalie Gruber, Kasia M. Kready, Devin R.
Burrill, Jeffrey C. Way, and Pamela A. Silver. “Rational Engineering of an Erythropoietin
Fusion Protein to Treat Hypoxia.” Protein Engineering, Design and Selection.
Oxford University Press, 2021. https://doi.org/10.1093/protein/gzab025.
ieee: J. Lee et al., “Rational engineering of an erythropoietin fusion protein
to treat hypoxia,” Protein Engineering, Design and Selection, vol. 34.
Oxford University Press, 2021.
ista: Lee J, Vernet A, Gruber N, Kready KM, Burrill DR, Way JC, Silver PA. 2021.
Rational engineering of an erythropoietin fusion protein to treat hypoxia. Protein
Engineering, Design and Selection. 34, gzab025.
mla: Lee, Jungmin, et al. “Rational Engineering of an Erythropoietin Fusion Protein
to Treat Hypoxia.” Protein Engineering, Design and Selection, vol. 34,
gzab025, Oxford University Press, 2021, doi:10.1093/protein/gzab025.
short: J. Lee, A. Vernet, N. Gruber, K.M. Kready, D.R. Burrill, J.C. Way, P.A. Silver,
Protein Engineering, Design and Selection 34 (2021).
date_created: 2021-11-28T23:01:28Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2023-08-14T13:01:38Z
day: '01'
department:
- _id: CaGu
doi: 10.1093/protein/gzab025
external_id:
isi:
- '000746596900001'
pmid:
- '34725710'
intvolume: ' 34'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1093/protein/gzab025
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Protein Engineering, Design and Selection
publication_identifier:
eissn:
- 1741-0134
issn:
- 1741-0126
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rational engineering of an erythropoietin fusion protein to treat hypoxia
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 34
year: '2021'
...
---
_id: '10366'
article_number: '203758'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Ana Maria
full_name: Lennon, Ana Maria
last_name: Lennon
- first_name: Roberto
full_name: Mayor, Roberto
last_name: Mayor
- first_name: Guillaume
full_name: Salbreux, Guillaume
last_name: Salbreux
citation:
ama: 'Heisenberg C-PJ, Lennon AM, Mayor R, Salbreux G. Special rebranding issue:
“Quantitative cell and developmental biology.” Cells and Development. 2021;168(12).
doi:10.1016/j.cdev.2021.203758'
apa: 'Heisenberg, C.-P. J., Lennon, A. M., Mayor, R., & Salbreux, G. (2021).
Special rebranding issue: “Quantitative cell and developmental biology.” Cells
and Development. Elsevier. https://doi.org/10.1016/j.cdev.2021.203758'
chicago: 'Heisenberg, Carl-Philipp J, Ana Maria Lennon, Roberto Mayor, and Guillaume
Salbreux. “Special Rebranding Issue: ‘Quantitative Cell and Developmental Biology.’”
Cells and Development. Elsevier, 2021. https://doi.org/10.1016/j.cdev.2021.203758.'
ieee: 'C.-P. J. Heisenberg, A. M. Lennon, R. Mayor, and G. Salbreux, “Special rebranding
issue: ‘Quantitative cell and developmental biology,’” Cells and Development,
vol. 168, no. 12. Elsevier, 2021.'
ista: 'Heisenberg C-PJ, Lennon AM, Mayor R, Salbreux G. 2021. Special rebranding
issue: “Quantitative cell and developmental biology”. Cells and Development. 168(12),
203758.'
mla: 'Heisenberg, Carl-Philipp J., et al. “Special Rebranding Issue: ‘Quantitative
Cell and Developmental Biology.’” Cells and Development, vol. 168, no.
12, 203758, Elsevier, 2021, doi:10.1016/j.cdev.2021.203758.'
short: C.-P.J. Heisenberg, A.M. Lennon, R. Mayor, G. Salbreux, Cells and Development
168 (2021).
date_created: 2021-11-28T23:01:30Z
date_published: 2021-11-17T00:00:00Z
date_updated: 2023-08-14T13:02:40Z
day: '17'
department:
- _id: CaHe
doi: 10.1016/j.cdev.2021.203758
external_id:
isi:
- '000974771600028'
pmid:
- '34800748'
intvolume: ' 168'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cdev.2021.203758
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cells and Development
publication_identifier:
issn:
- 2667-2901
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Special rebranding issue: “Quantitative cell and developmental biology”'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 168
year: '2021'
...
---
_id: '10402'
abstract:
- lang: eng
text: Branching morphogenesis governs the formation of many organs such as lung,
kidney, and the neurovascular system. Many studies have explored system-specific
molecular and cellular regulatory mechanisms, as well as self-organizing rules
underlying branching morphogenesis. However, in addition to local cues, branched
tissue growth can also be influenced by global guidance. Here, we develop a theoretical
framework for a stochastic self-organized branching process in the presence of
external cues. Combining analytical theory with numerical simulations, we predict
differential signatures of global vs. local regulatory mechanisms on the branching
pattern, such as angle distributions, domain size, and space-filling efficiency.
We find that branch alignment follows a generic scaling law determined by the
strength of global guidance, while local interactions influence the tissue density
but not its overall territory. Finally, using zebrafish innervation as a model
system, we test these key features of the model experimentally. Our work thus
provides quantitative predictions to disentangle the role of different types of
cues in shaping branched structures across scales.
acknowledgement: We thank all members of our respective groups for helpful discussion
on the paper. The authors are also grateful to Prof. Abdel El. Manira for support
and sharing Tg(HUC:Gal4;UAS:Synaptohysin-GFP), to Haohao Wu for discussion, and
thank Elena Zabalueva for the zebrafish schematic. The authors also acknowledge
Zebrafish core facility, Genome Engineering Zebrafish and Biomedicum Imaging Core
from the Karolinska Institutet for technical support. This work received funding
from the ERC under the European Union’s Horizon 2020 research and innovation programme
(grant agreement No. 851288 to E.H.) and under the Marie Skłodowska-Curie grant
agreement No. 754411 (to M.C.U.); Swedish Research Council (to F.L., I.A. and S.H.);
Knut and Alice Wallenberg Foundation (F.L. and I.A.); Swedish Brain Foundation (F.L.
and S.H.); Ming Wai Lau Foundation (to F.L.); StratRegen (to F.L.); ERC Consolidator
grant STEMMING-FROM-NERVE and ERC Synergy Grant KILL-OR-DIFFERENTIATE (to I.A.);
Bertil Hallsten Research Foundation (to I.A.); Cancerfonden (to I.A.); the Paradifference
Foundation (to I.A.); Austrian Science Fund (to I.A.); and StratNeuro (to S.H.).
article_number: '6830'
article_processing_charge: No
article_type: original
author:
- first_name: Mehmet C
full_name: Ucar, Mehmet C
id: 50B2A802-6007-11E9-A42B-EB23E6697425
last_name: Ucar
orcid: 0000-0003-0506-4217
- first_name: Dmitrii
full_name: Kamenev, Dmitrii
last_name: Kamenev
- first_name: Kazunori
full_name: Sunadome, Kazunori
last_name: Sunadome
- first_name: Dominik C
full_name: Fachet, Dominik C
id: 14FDD550-AA41-11E9-A0E5-1ACCE5697425
last_name: Fachet
- first_name: Francois
full_name: Lallemend, Francois
last_name: Lallemend
- first_name: Igor
full_name: Adameyko, Igor
last_name: Adameyko
- first_name: Saida
full_name: Hadjab, Saida
last_name: Hadjab
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Ucar MC, Kamenev D, Sunadome K, et al. Theory of branching morphogenesis by
local interactions and global guidance. Nature Communications. 2021;12.
doi:10.1038/s41467-021-27135-5
apa: Ucar, M. C., Kamenev, D., Sunadome, K., Fachet, D. C., Lallemend, F., Adameyko,
I., … Hannezo, E. B. (2021). Theory of branching morphogenesis by local interactions
and global guidance. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-021-27135-5
chicago: Ucar, Mehmet C, Dmitrii Kamenev, Kazunori Sunadome, Dominik C Fachet, Francois
Lallemend, Igor Adameyko, Saida Hadjab, and Edouard B Hannezo. “Theory of Branching
Morphogenesis by Local Interactions and Global Guidance.” Nature Communications.
Springer Nature, 2021. https://doi.org/10.1038/s41467-021-27135-5.
ieee: M. C. Ucar et al., “Theory of branching morphogenesis by local interactions
and global guidance,” Nature Communications, vol. 12. Springer Nature,
2021.
ista: Ucar MC, Kamenev D, Sunadome K, Fachet DC, Lallemend F, Adameyko I, Hadjab
S, Hannezo EB. 2021. Theory of branching morphogenesis by local interactions and
global guidance. Nature Communications. 12, 6830.
mla: Ucar, Mehmet C., et al. “Theory of Branching Morphogenesis by Local Interactions
and Global Guidance.” Nature Communications, vol. 12, 6830, Springer Nature,
2021, doi:10.1038/s41467-021-27135-5.
short: M.C. Ucar, D. Kamenev, K. Sunadome, D.C. Fachet, F. Lallemend, I. Adameyko,
S. Hadjab, E.B. Hannezo, Nature Communications 12 (2021).
date_created: 2021-12-05T23:01:40Z
date_published: 2021-11-24T00:00:00Z
date_updated: 2023-08-14T13:18:46Z
day: '24'
ddc:
- '573'
department:
- _id: EdHa
doi: 10.1038/s41467-021-27135-5
ec_funded: 1
external_id:
isi:
- '000722322900020'
pmid:
- '34819507'
file:
- access_level: open_access
checksum: 63c56ec75314a71e63e7dd2920b3c5b5
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-10T08:54:09Z
date_updated: 2021-12-10T08:54:09Z
file_id: '10529'
file_name: 2021_NatComm_Ucar.pdf
file_size: 2303405
relation: main_file
success: 1
file_date_updated: 2021-12-10T08:54:09Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '13058'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Theory of branching morphogenesis by local interactions and global guidance
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2021'
...
---
_id: '10407'
abstract:
- lang: eng
text: Digital hardware Trojans are integrated circuits whose implementation differ
from the specification in an arbitrary and malicious way. For example, the circuit
can differ from its specified input/output behavior after some fixed number of
queries (known as “time bombs”) or on some particular input (known as “cheat codes”).
To detect such Trojans, countermeasures using multiparty computation (MPC) or
verifiable computation (VC) have been proposed. On a high level, to realize a
circuit with specification F one has more sophisticated circuits F⋄ manufactured
(where F⋄ specifies a MPC or VC of F ), and then embeds these F⋄ ’s into
a master circuit which must be trusted but is relatively simple compared to F
. Those solutions impose a significant overhead as F⋄ is much more complex
than F , also the master circuits are not exactly trivial. In this work, we
show that in restricted settings, where F has no evolving state and is queried
on independent inputs, we can achieve a relaxed security notion using very simple
constructions. In particular, we do not change the specification of the circuit
at all (i.e., F=F⋄ ). Moreover the master circuit basically just queries a subset
of its manufactured circuits and checks if they’re all the same. The security
we achieve guarantees that, if the manufactured circuits are initially tested
on up to T inputs, the master circuit will catch Trojans that try to deviate on
significantly more than a 1/T fraction of the inputs. This bound is optimal for
the type of construction considered, and we provably achieve it using a construction
where 12 instantiations of F need to be embedded into the master. We also discuss
an extremely simple construction with just 2 instantiations for which we conjecture
that it already achieves the optimal bound.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Suvradip
full_name: Chakraborty, Suvradip
id: B9CD0494-D033-11E9-B219-A439E6697425
last_name: Chakraborty
- first_name: Stefan
full_name: Dziembowski, Stefan
last_name: Dziembowski
- first_name: Małgorzata
full_name: Gałązka, Małgorzata
last_name: Gałązka
- first_name: Tomasz
full_name: Lizurej, Tomasz
last_name: Lizurej
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
- first_name: Michelle X
full_name: Yeo, Michelle X
id: 2D82B818-F248-11E8-B48F-1D18A9856A87
last_name: Yeo
citation:
ama: 'Chakraborty S, Dziembowski S, Gałązka M, Lizurej T, Pietrzak KZ, Yeo MX. Trojan-resilience
without cryptography. In: Vol 13043. Springer Nature; 2021:397-428. doi:10.1007/978-3-030-90453-1_14'
apa: 'Chakraborty, S., Dziembowski, S., Gałązka, M., Lizurej, T., Pietrzak, K. Z.,
& Yeo, M. X. (2021). Trojan-resilience without cryptography (Vol. 13043, pp.
397–428). Presented at the TCC: Theory of Cryptography Conference, Raleigh, NC,
United States: Springer Nature. https://doi.org/10.1007/978-3-030-90453-1_14'
chicago: Chakraborty, Suvradip, Stefan Dziembowski, Małgorzata Gałązka, Tomasz Lizurej,
Krzysztof Z Pietrzak, and Michelle X Yeo. “Trojan-Resilience without Cryptography,”
13043:397–428. Springer Nature, 2021. https://doi.org/10.1007/978-3-030-90453-1_14.
ieee: 'S. Chakraborty, S. Dziembowski, M. Gałązka, T. Lizurej, K. Z. Pietrzak, and
M. X. Yeo, “Trojan-resilience without cryptography,” presented at the TCC: Theory
of Cryptography Conference, Raleigh, NC, United States, 2021, vol. 13043, pp.
397–428.'
ista: 'Chakraborty S, Dziembowski S, Gałązka M, Lizurej T, Pietrzak KZ, Yeo MX.
2021. Trojan-resilience without cryptography. TCC: Theory of Cryptography Conference,
LNCS, vol. 13043, 397–428.'
mla: Chakraborty, Suvradip, et al. Trojan-Resilience without Cryptography.
Vol. 13043, Springer Nature, 2021, pp. 397–428, doi:10.1007/978-3-030-90453-1_14.
short: S. Chakraborty, S. Dziembowski, M. Gałązka, T. Lizurej, K.Z. Pietrzak, M.X.
Yeo, in:, Springer Nature, 2021, pp. 397–428.
conference:
end_date: 2021-11-11
location: Raleigh, NC, United States
name: 'TCC: Theory of Cryptography Conference'
start_date: 2021-11-08
date_created: 2021-12-05T23:01:42Z
date_published: 2021-11-04T00:00:00Z
date_updated: 2023-08-14T13:07:46Z
day: '04'
department:
- _id: KrPi
doi: 10.1007/978-3-030-90453-1_14
ec_funded: 1
external_id:
isi:
- '000728364000014'
intvolume: ' 13043'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2021/1224
month: '11'
oa: 1
oa_version: Preprint
page: 397-428
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
publication_identifier:
eissn:
- 1611-3349
isbn:
- 9-783-0309-0452-4
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Trojan-resilience without cryptography
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13043
year: '2021'
...
---
_id: '10403'
abstract:
- lang: eng
text: Synaptic transmission, connectivity, and dendritic morphology mature in parallel
during brain development and are often disrupted in neurodevelopmental disorders.
Yet how these changes influence the neuronal computations necessary for normal
brain function are not well understood. To identify cellular mechanisms underlying
the maturation of synaptic integration in interneurons, we combined patch-clamp
recordings of excitatory inputs in mouse cerebellar stellate cells (SCs), three-dimensional
reconstruction of SC morphology with excitatory synapse location, and biophysical
modeling. We found that postnatal maturation of postsynaptic strength was homogeneously
reduced along the somatodendritic axis, but dendritic integration was always sublinear.
However, dendritic branching increased without changes in synapse density, leading
to a substantial gain in distal inputs. Thus, changes in synapse distribution,
rather than dendrite cable properties, are the dominant mechanism underlying the
maturation of neuronal computation. These mechanisms favor the emergence of a
spatially compartmentalized two-stage integration model promoting location-dependent
integration within dendritic subunits.
acknowledgement: This study was supported by the Centre National de la Recherche Scientifique
and the Agence Nationale de la Recherche (ANR-13-BSV4-00166, to LC and DAD). TA
was supported by fellowships from the Fondation pour la Recherche Medicale and the
Swedish Research Council. We thank Dmitry Ershov from the Image Analysis Hub of
the Institut Pasteur, Elodie Le Monnier, Elena Hollergschwandtner, Vanessa Zheden,
and Corinne Nantet for technical support and Haining Zhong for providing the Venus-tagged
PSD95 mouse line. We would like to thank Alberto Bacci, Ann Lohof, and Nelson Rebola
for comments on the manuscript.
article_number: e65954
article_processing_charge: No
article_type: original
author:
- first_name: Celia
full_name: Biane, Celia
last_name: Biane
- first_name: Florian
full_name: Rückerl, Florian
last_name: Rückerl
- first_name: Therese
full_name: Abrahamsson, Therese
last_name: Abrahamsson
- first_name: Cécile
full_name: Saint-Cloment, Cécile
last_name: Saint-Cloment
- first_name: Jean
full_name: Mariani, Jean
last_name: Mariani
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: David A.
full_name: Digregorio, David A.
last_name: Digregorio
- first_name: Rachel M.
full_name: Sherrard, Rachel M.
last_name: Sherrard
- first_name: Laurence
full_name: Cathala, Laurence
last_name: Cathala
citation:
ama: Biane C, Rückerl F, Abrahamsson T, et al. Developmental emergence of two-stage
nonlinear synaptic integration in cerebellar interneurons. eLife. 2021;10.
doi:10.7554/eLife.65954
apa: Biane, C., Rückerl, F., Abrahamsson, T., Saint-Cloment, C., Mariani, J., Shigemoto,
R., … Cathala, L. (2021). Developmental emergence of two-stage nonlinear synaptic
integration in cerebellar interneurons. ELife. eLife Sciences Publications.
https://doi.org/10.7554/eLife.65954
chicago: Biane, Celia, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment,
Jean Mariani, Ryuichi Shigemoto, David A. Digregorio, Rachel M. Sherrard, and
Laurence Cathala. “Developmental Emergence of Two-Stage Nonlinear Synaptic Integration
in Cerebellar Interneurons.” ELife. eLife Sciences Publications, 2021.
https://doi.org/10.7554/eLife.65954.
ieee: C. Biane et al., “Developmental emergence of two-stage nonlinear synaptic
integration in cerebellar interneurons,” eLife, vol. 10. eLife Sciences
Publications, 2021.
ista: Biane C, Rückerl F, Abrahamsson T, Saint-Cloment C, Mariani J, Shigemoto R,
Digregorio DA, Sherrard RM, Cathala L. 2021. Developmental emergence of two-stage
nonlinear synaptic integration in cerebellar interneurons. eLife. 10, e65954.
mla: Biane, Celia, et al. “Developmental Emergence of Two-Stage Nonlinear Synaptic
Integration in Cerebellar Interneurons.” ELife, vol. 10, e65954, eLife
Sciences Publications, 2021, doi:10.7554/eLife.65954.
short: C. Biane, F. Rückerl, T. Abrahamsson, C. Saint-Cloment, J. Mariani, R. Shigemoto,
D.A. Digregorio, R.M. Sherrard, L. Cathala, ELife 10 (2021).
date_created: 2021-12-05T23:01:40Z
date_published: 2021-11-03T00:00:00Z
date_updated: 2023-08-14T13:12:07Z
day: '03'
ddc:
- '570'
department:
- _id: RySh
doi: 10.7554/eLife.65954
external_id:
isi:
- '000715789500001'
file:
- access_level: open_access
checksum: c7c33c3319428d56e332e22349c50ed3
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-10T08:31:41Z
date_updated: 2021-12-10T08:31:41Z
file_id: '10528'
file_name: 2021_eLife_Biane.pdf
file_size: 13131322
relation: main_file
success: 1
file_date_updated: 2021-12-10T08:31:41Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmental emergence of two-stage nonlinear synaptic integration in cerebellar
interneurons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '10401'
abstract:
- lang: eng
text: Theoretical and experimental studies of the interaction between spins and
temperature are vital for the development of spin caloritronics, as they dictate
the design of future devices. In this work, we propose a two-terminal cold-atom
simulator to study that interaction. The proposed quantum simulator consists of
strongly interacting atoms that occupy two temperature reservoirs connected by
a one-dimensional link. First, we argue that the dynamics in the link can be described
using an inhomogeneous Heisenberg spin chain whose couplings are defined by the
local temperature. Second, we show the existence of a spin current in a system
with a temperature difference by studying the dynamics that follows the spin-flip
of an atom in the link. A temperature gradient accelerates the impurity in one
direction more than in the other, leading to an overall spin current similar to
the spin Seebeck effect.
acknowledgement: The authors acknowledge support from the European QuantERA ERA-NET
Cofund in Quantum Technologies (Project QTFLAG Grant Agreement No. 731473) (R.E.B),
CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) Brazil (A.F.),
the European Union’s Horizon 2020 research and innovation programme under the Marie
Skłodowska-Curie Grant Agreement No. 754411 (A.G.V.), the Independent Research Fund
Denmark, the Carlsberg Foundation, and Aarhus University Research Foundation under
the Jens Christian Skou fellowship program (N.T.Z).
article_number: '252'
article_processing_charge: No
article_type: original
author:
- first_name: Rafael E.
full_name: Barfknecht, Rafael E.
last_name: Barfknecht
- first_name: Angela
full_name: Foerster, Angela
last_name: Foerster
- first_name: Nikolaj T.
full_name: Zinner, Nikolaj T.
last_name: Zinner
- first_name: Artem
full_name: Volosniev, Artem
id: 37D278BC-F248-11E8-B48F-1D18A9856A87
last_name: Volosniev
orcid: 0000-0003-0393-5525
citation:
ama: Barfknecht RE, Foerster A, Zinner NT, Volosniev A. Generation of spin currents
by a temperature gradient in a two-terminal device. Communications Physics.
2021;4(1). doi:10.1038/s42005-021-00753-7
apa: Barfknecht, R. E., Foerster, A., Zinner, N. T., & Volosniev, A. (2021).
Generation of spin currents by a temperature gradient in a two-terminal device.
Communications Physics. Springer Nature. https://doi.org/10.1038/s42005-021-00753-7
chicago: Barfknecht, Rafael E., Angela Foerster, Nikolaj T. Zinner, and Artem Volosniev.
“Generation of Spin Currents by a Temperature Gradient in a Two-Terminal Device.”
Communications Physics. Springer Nature, 2021. https://doi.org/10.1038/s42005-021-00753-7.
ieee: R. E. Barfknecht, A. Foerster, N. T. Zinner, and A. Volosniev, “Generation
of spin currents by a temperature gradient in a two-terminal device,” Communications
Physics, vol. 4, no. 1. Springer Nature, 2021.
ista: Barfknecht RE, Foerster A, Zinner NT, Volosniev A. 2021. Generation of spin
currents by a temperature gradient in a two-terminal device. Communications Physics.
4(1), 252.
mla: Barfknecht, Rafael E., et al. “Generation of Spin Currents by a Temperature
Gradient in a Two-Terminal Device.” Communications Physics, vol. 4, no.
1, 252, Springer Nature, 2021, doi:10.1038/s42005-021-00753-7.
short: R.E. Barfknecht, A. Foerster, N.T. Zinner, A. Volosniev, Communications Physics
4 (2021).
date_created: 2021-12-05T23:01:39Z
date_published: 2021-11-26T00:00:00Z
date_updated: 2023-08-14T13:04:34Z
day: '26'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1038/s42005-021-00753-7
ec_funded: 1
external_id:
arxiv:
- '2101.02020'
isi:
- 10.1038/s42005-021-00753-7
file:
- access_level: open_access
checksum: 9097319952cb9a3d96e7fd3aa9813a03
content_type: application/pdf
creator: alisjak
date_created: 2021-12-06T14:53:41Z
date_updated: 2021-12-06T14:53:41Z
file_id: '10420'
file_name: 2021_NatComm_Barfknecht.pdf
file_size: 1068984
relation: main_file
success: 1
file_date_updated: 2021-12-06T14:53:41Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Communications Physics
publication_identifier:
eissn:
- '23993650'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Generation of spin currents by a temperature gradient in a two-terminal device
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 4
year: '2021'
...
---
_id: '10404'
abstract:
- lang: eng
text: While convolutional neural networks (CNNs) have found wide adoption as state-of-the-art
models for image-related tasks, their predictions are often highly sensitive to
small input perturbations, which the human vision is robust against. This paper
presents Perturber, a web-based application that allows users to instantaneously
explore how CNN activations and predictions evolve when a 3D input scene is interactively
perturbed. Perturber offers a large variety of scene modifications, such as camera
controls, lighting and shading effects, background modifications, object morphing,
as well as adversarial attacks, to facilitate the discovery of potential vulnerabilities.
Fine-tuned model versions can be directly compared for qualitative evaluation
of their robustness. Case studies with machine learning experts have shown that
Perturber helps users to quickly generate hypotheses about model vulnerabilities
and to qualitatively compare model behavior. Using quantitative analyses, we could
replicate users’ insights with other CNN architectures and input images, yielding
new insights about the vulnerability of adversarially trained models.
acknowledgement: "We thank Robert Geirhos and Roland Zimmermann for their participation
in the case study and valuable feedback, Chris Olah and Nick Cammarata for valuable
discussions in the early phase of the project, as well as the Distill Slack workspace
as a platform for discussions. M.L. is supported in part by the Austrian Science
Fund (FWF) under grant Z211-N23 (Wittgenstein Award). J.B. is supported by the German
Federal Ministry of Education and Research\r\n(BMBF) through the Competence Center
for Machine Learning (TUE.AI, FKZ 01IS18039A) and the International Max Planck Research
School for Intelligent Systems (IMPRS-IS). R.H. is partially supported by Boeing
and Horizon-2020 ECSEL (grant 783163, iDev40).\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Stefan
full_name: Sietzen, Stefan
last_name: Sietzen
- first_name: Mathias
full_name: Lechner, Mathias
id: 3DC22916-F248-11E8-B48F-1D18A9856A87
last_name: Lechner
- first_name: Judy
full_name: Borowski, Judy
last_name: Borowski
- first_name: Ramin
full_name: Hasani, Ramin
last_name: Hasani
- first_name: Manuela
full_name: Waldner, Manuela
last_name: Waldner
citation:
ama: Sietzen S, Lechner M, Borowski J, Hasani R, Waldner M. Interactive analysis
of CNN robustness. Computer Graphics Forum. 2021;40(7):253-264. doi:10.1111/cgf.14418
apa: Sietzen, S., Lechner, M., Borowski, J., Hasani, R., & Waldner, M. (2021).
Interactive analysis of CNN robustness. Computer Graphics Forum. Wiley.
https://doi.org/10.1111/cgf.14418
chicago: Sietzen, Stefan, Mathias Lechner, Judy Borowski, Ramin Hasani, and Manuela
Waldner. “Interactive Analysis of CNN Robustness.” Computer Graphics Forum.
Wiley, 2021. https://doi.org/10.1111/cgf.14418.
ieee: S. Sietzen, M. Lechner, J. Borowski, R. Hasani, and M. Waldner, “Interactive
analysis of CNN robustness,” Computer Graphics Forum, vol. 40, no. 7. Wiley,
pp. 253–264, 2021.
ista: Sietzen S, Lechner M, Borowski J, Hasani R, Waldner M. 2021. Interactive analysis
of CNN robustness. Computer Graphics Forum. 40(7), 253–264.
mla: Sietzen, Stefan, et al. “Interactive Analysis of CNN Robustness.” Computer
Graphics Forum, vol. 40, no. 7, Wiley, 2021, pp. 253–64, doi:10.1111/cgf.14418.
short: S. Sietzen, M. Lechner, J. Borowski, R. Hasani, M. Waldner, Computer Graphics
Forum 40 (2021) 253–264.
date_created: 2021-12-05T23:01:40Z
date_published: 2021-11-27T00:00:00Z
date_updated: 2023-08-14T13:11:42Z
day: '27'
department:
- _id: ToHe
doi: 10.1111/cgf.14418
external_id:
arxiv:
- '2110.07667'
isi:
- '000722952000024'
intvolume: ' 40'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2110.07667
month: '11'
oa: 1
oa_version: Preprint
page: 253-264
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: Computer Graphics Forum
publication_identifier:
eissn:
- 1467-8659
issn:
- 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactive analysis of CNN robustness
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 40
year: '2021'
...
---
_id: '10406'
abstract:
- lang: eng
text: Multicellular organisms develop complex shapes from much simpler, single-celled
zygotes through a process commonly called morphogenesis. Morphogenesis involves
an interplay between several factors, ranging from the gene regulatory networks
determining cell fate and differentiation to the mechanical processes underlying
cell and tissue shape changes. Thus, the study of morphogenesis has historically
been based on multidisciplinary approaches at the interface of biology with physics
and mathematics. Recent technological advances have further improved our ability
to study morphogenesis by bridging the gap between the genetic and biophysical
factors through the development of new tools for visualizing, analyzing, and perturbing
these factors and their biochemical intermediaries. Here, we review how a combination
of genetic, microscopic, biophysical, and biochemical approaches has aided our
attempts to understand morphogenesis and discuss potential approaches that may
be beneficial to such an inquiry in the future.
acknowledgement: The authors would like to thank Feyza Nur Arslan, Suyash Naik, Diana
Pinheiro, Alexandra Schauer, and Shayan Shamipour for their comments on the draft.
N.M. is supported by an ISTplus postdoctoral fellowship (H2020 Marie-Sklodowska-Curie
COFUND Action).
article_processing_charge: No
article_type: original
author:
- first_name: Nikhil
full_name: Mishra, Nikhil
id: C4D70E82-1081-11EA-B3ED-9A4C3DDC885E
last_name: Mishra
orcid: 0000-0002-6425-5788
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Mishra N, Heisenberg C-PJ. Dissecting organismal morphogenesis by bridging
genetics and biophysics. Annual Review of Genetics. 2021;55:209-233. doi:10.1146/annurev-genet-071819-103748
apa: Mishra, N., & Heisenberg, C.-P. J. (2021). Dissecting organismal morphogenesis
by bridging genetics and biophysics. Annual Review of Genetics. Annual
Reviews. https://doi.org/10.1146/annurev-genet-071819-103748
chicago: Mishra, Nikhil, and Carl-Philipp J Heisenberg. “Dissecting Organismal Morphogenesis
by Bridging Genetics and Biophysics.” Annual Review of Genetics. Annual
Reviews, 2021. https://doi.org/10.1146/annurev-genet-071819-103748.
ieee: N. Mishra and C.-P. J. Heisenberg, “Dissecting organismal morphogenesis by
bridging genetics and biophysics,” Annual Review of Genetics, vol. 55.
Annual Reviews, pp. 209–233, 2021.
ista: Mishra N, Heisenberg C-PJ. 2021. Dissecting organismal morphogenesis by bridging
genetics and biophysics. Annual Review of Genetics. 55, 209–233.
mla: Mishra, Nikhil, and Carl-Philipp J. Heisenberg. “Dissecting Organismal Morphogenesis
by Bridging Genetics and Biophysics.” Annual Review of Genetics, vol. 55,
Annual Reviews, 2021, pp. 209–33, doi:10.1146/annurev-genet-071819-103748.
short: N. Mishra, C.-P.J. Heisenberg, Annual Review of Genetics 55 (2021) 209–233.
date_created: 2021-12-05T23:01:41Z
date_published: 2021-08-30T00:00:00Z
date_updated: 2023-08-14T13:05:13Z
day: '30'
department:
- _id: CaHe
doi: 10.1146/annurev-genet-071819-103748
ec_funded: 1
external_id:
isi:
- '000747220900010'
pmid:
- '34460295'
intvolume: ' 55'
isi: 1
keyword:
- morphogenesis
- forward genetics
- high-resolution microscopy
- biophysics
- biochemistry
- patterning
language:
- iso: eng
month: '08'
oa_version: None
page: 209-233
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Annual Review of Genetics
publication_identifier:
eissn:
- 1545-2948
issn:
- 0066-4197
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dissecting organismal morphogenesis by bridging genetics and biophysics
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 55
year: '2021'
...
---
_id: '13058'
abstract:
- lang: eng
text: The zip file includes source data used in the main text of the manuscript
"Theory of branching morphogenesis by local interactions and global guidance",
as well as a representative Jupyter notebook to reproduce the main figures. A
sample script for the simulations of branching and annihilating random walks is
also included (Sample_script_for_simulations_of_BARWs.ipynb) to generate exemplary
branched networks under external guidance. A detailed description of the simulation
setup is provided in the supplementary information of the manuscipt.
article_processing_charge: No
author:
- first_name: Mehmet C
full_name: Ucar, Mehmet C
id: 50B2A802-6007-11E9-A42B-EB23E6697425
last_name: Ucar
orcid: 0000-0003-0506-4217
citation:
ama: Ucar MC. Source data for the manuscript “Theory of branching morphogenesis
by local interactions and global guidance.” 2021. doi:10.5281/ZENODO.5257160
apa: Ucar, M. C. (2021). Source data for the manuscript “Theory of branching morphogenesis
by local interactions and global guidance.” Zenodo. https://doi.org/10.5281/ZENODO.5257160
chicago: Ucar, Mehmet C. “Source Data for the Manuscript ‘Theory of Branching Morphogenesis
by Local Interactions and Global Guidance.’” Zenodo, 2021. https://doi.org/10.5281/ZENODO.5257160.
ieee: M. C. Ucar, “Source data for the manuscript ‘Theory of branching morphogenesis
by local interactions and global guidance.’” Zenodo, 2021.
ista: Ucar MC. 2021. Source data for the manuscript ‘Theory of branching morphogenesis
by local interactions and global guidance’, Zenodo, 10.5281/ZENODO.5257160.
mla: Ucar, Mehmet C. Source Data for the Manuscript “Theory of Branching Morphogenesis
by Local Interactions and Global Guidance.” Zenodo, 2021, doi:10.5281/ZENODO.5257160.
short: M.C. Ucar, (2021).
date_created: 2023-05-23T13:46:34Z
date_published: 2021-08-25T00:00:00Z
date_updated: 2023-08-14T13:18:46Z
day: '25'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.5281/ZENODO.5257160
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/zenodo.5257161
month: '08'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '10402'
relation: used_in_publication
status: public
status: public
title: Source data for the manuscript "Theory of branching morphogenesis by local
interactions and global guidance"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '10408'
abstract:
- lang: eng
text: 'Key trees are often the best solution in terms of transmission cost and storage
requirements for managing keys in a setting where a group needs to share a secret
key, while being able to efficiently rotate the key material of users (in order
to recover from a potential compromise, or to add or remove users). Applications
include multicast encryption protocols like LKH (Logical Key Hierarchies) or group
messaging like the current IETF proposal TreeKEM. A key tree is a (typically balanced)
binary tree, where each node is identified with a key: leaf nodes hold users’
secret keys while the root is the shared group key. For a group of size N, each
user just holds log(N) keys (the keys on the path from its leaf to the root)
and its entire key material can be rotated by broadcasting 2log(N) ciphertexts
(encrypting each fresh key on the path under the keys of its parents). In this
work we consider the natural setting where we have many groups with partially
overlapping sets of users, and ask if we can find solutions where the cost of
rotating a key is better than in the trivial one where we have a separate key
tree for each group. We show that in an asymptotic setting (where the number m
of groups is fixed while the number N of users grows) there exist more general
key graphs whose cost converges to the cost of a single group, thus saving a factor
linear in the number of groups over the trivial solution. As our asymptotic “solution”
converges very slowly and performs poorly on concrete examples, we propose an
algorithm that uses a natural heuristic to compute a key graph for any given group
structure. Our algorithm combines two greedy algorithms, and is thus very efficient:
it first converts the group structure into a “lattice graph”, which is then turned
into a key graph by repeatedly applying the algorithm for constructing a Huffman
code. To better understand how far our proposal is from an optimal solution, we
prove lower bounds on the update cost of continuous group-key agreement and multicast
encryption in a symbolic model admitting (asymmetric) encryption, pseudorandom
generators, and secret sharing as building blocks.'
acknowledgement: B. Auerbach, M.A. Baig and K. Pietrzak—received funding from the
European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme (682815 - TOCNeT); Karen Klein was supported in part by
ERC CoG grant 724307 and conducted part of this work at IST Austria, funded by the
ERC under the European Union’s Horizon 2020 research and innovation programme (682815
- TOCNeT); Guillermo Pascual-Perez was funded by the European Union’s Horizon 2020
research and innovation programme under the Marie Skłodowska-Curie Grant Agreement
No. 665385; Michael Walter conducted part of this work at IST Austria, funded by
the ERC under the European Union’s Horizon 2020 research and innovation programme
(682815 - TOCNeT).
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Joel F
full_name: Alwen, Joel F
id: 2A8DFA8C-F248-11E8-B48F-1D18A9856A87
last_name: Alwen
- first_name: Benedikt
full_name: Auerbach, Benedikt
id: D33D2B18-E445-11E9-ABB7-15F4E5697425
last_name: Auerbach
orcid: 0000-0002-7553-6606
- first_name: Mirza Ahad
full_name: Baig, Mirza Ahad
id: 3EDE6DE4-AA5A-11E9-986D-341CE6697425
last_name: Baig
- first_name: Miguel
full_name: Cueto Noval, Miguel
id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
last_name: Cueto Noval
- first_name: Karen
full_name: Klein, Karen
id: 3E83A2F8-F248-11E8-B48F-1D18A9856A87
last_name: Klein
- first_name: Guillermo
full_name: Pascual Perez, Guillermo
id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87
last_name: Pascual Perez
orcid: 0000-0001-8630-415X
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
- first_name: Michael
full_name: Walter, Michael
id: 488F98B0-F248-11E8-B48F-1D18A9856A87
last_name: Walter
orcid: 0000-0003-3186-2482
citation:
ama: 'Alwen JF, Auerbach B, Baig MA, et al. Grafting key trees: Efficient key management
for overlapping groups. In: 19th International Conference. Vol 13044. Springer
Nature; 2021:222-253. doi:10.1007/978-3-030-90456-2_8'
apa: 'Alwen, J. F., Auerbach, B., Baig, M. A., Cueto Noval, M., Klein, K., Pascual
Perez, G., … Walter, M. (2021). Grafting key trees: Efficient key management for
overlapping groups. In 19th International Conference (Vol. 13044, pp. 222–253).
Raleigh, NC, United States: Springer Nature. https://doi.org/10.1007/978-3-030-90456-2_8'
chicago: 'Alwen, Joel F, Benedikt Auerbach, Mirza Ahad Baig, Miguel Cueto Noval,
Karen Klein, Guillermo Pascual Perez, Krzysztof Z Pietrzak, and Michael Walter.
“Grafting Key Trees: Efficient Key Management for Overlapping Groups.” In 19th
International Conference, 13044:222–53. Springer Nature, 2021. https://doi.org/10.1007/978-3-030-90456-2_8.'
ieee: 'J. F. Alwen et al., “Grafting key trees: Efficient key management
for overlapping groups,” in 19th International Conference, Raleigh, NC,
United States, 2021, vol. 13044, pp. 222–253.'
ista: 'Alwen JF, Auerbach B, Baig MA, Cueto Noval M, Klein K, Pascual Perez G, Pietrzak
KZ, Walter M. 2021. Grafting key trees: Efficient key management for overlapping
groups. 19th International Conference. TCC: Theory of Cryptography, LNCS, vol.
13044, 222–253.'
mla: 'Alwen, Joel F., et al. “Grafting Key Trees: Efficient Key Management for Overlapping
Groups.” 19th International Conference, vol. 13044, Springer Nature, 2021,
pp. 222–53, doi:10.1007/978-3-030-90456-2_8.'
short: J.F. Alwen, B. Auerbach, M.A. Baig, M. Cueto Noval, K. Klein, G. Pascual
Perez, K.Z. Pietrzak, M. Walter, in:, 19th International Conference, Springer
Nature, 2021, pp. 222–253.
conference:
end_date: 2021-11-11
location: Raleigh, NC, United States
name: 'TCC: Theory of Cryptography'
start_date: 2021-11-08
date_created: 2021-12-05T23:01:42Z
date_published: 2021-11-04T00:00:00Z
date_updated: 2023-08-14T13:19:39Z
day: '04'
department:
- _id: KrPi
doi: 10.1007/978-3-030-90456-2_8
ec_funded: 1
external_id:
isi:
- '000728363700008'
intvolume: ' 13044'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2021/1158
month: '11'
oa: 1
oa_version: Preprint
page: 222-253
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: 19th International Conference
publication_identifier:
eisbn:
- 978-3-030-90456-2
eissn:
- 1611-3349
isbn:
- 9-783-0309-0455-5
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Grafting key trees: Efficient key management for overlapping groups'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13044
year: '2021'
...
---
_id: '10527'
abstract:
- lang: eng
text: We show that in a two-dimensional electron gas with an annular Fermi surface,
long-range Coulomb interactions can lead to unconventional superconductivity by
the Kohn-Luttinger mechanism. Superconductivity is strongly enhanced when the
inner and outer Fermi surfaces are close to each other. The most prevalent state
has chiral p-wave symmetry, but d-wave and extended s-wave pairing are also possible.
We discuss these results in the context of rhombohedral trilayer graphene, where
superconductivity was recently discovered in regimes where the normal state has
an annular Fermi surface. Using realistic parameters, our mechanism can account
for the order of magnitude of Tc, as well as its trends as a function of electron
density and perpendicular displacement field. Moreover, it naturally explains
some of the outstanding puzzles in this material, that include the weak temperature
dependence of the resistivity above Tc, and the proximity of spin singlet superconductivity
to the ferromagnetic phase.
acknowledgement: We thank Yang-Zhi Chou, Andrey Chubukov, Johannes Hofmann, Steve
Kivelson, Sri Raghu, and Sankar das Sarma, Jay Sau, Fengcheng Wu, and Andrea Young
for many stimulating discussions and for their comments on the manuscript. E.B.
thanks S. Chatterjee, T. Wang, and M. Zaletel for a collaboration on a related topic.
A.G. acknowledges support by the European Unions Horizon 2020 research and innovation
program under the Marie Sklodowska-Curie Grant Agreement No. 754411. E.B. and T.H.
were supported by the European Research Council (ERC) under grant HQMAT (Grant Agreement
No. 817799), by the Israel-USA Binational Science Foundation (BSF), and by a Research
grant from Irving and Cherna Moskowitz.
article_number: '247001'
article_processing_charge: No
article_type: original
author:
- first_name: Areg
full_name: Ghazaryan, Areg
id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
last_name: Ghazaryan
orcid: 0000-0001-9666-3543
- first_name: Tobias
full_name: Holder, Tobias
last_name: Holder
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Erez
full_name: Berg, Erez
last_name: Berg
citation:
ama: 'Ghazaryan A, Holder T, Serbyn M, Berg E. Unconventional superconductivity
in systems with annular Fermi surfaces: Application to rhombohedral trilayer graphene.
Physical Review Letters. 2021;127(24). doi:10.1103/physrevlett.127.247001'
apa: 'Ghazaryan, A., Holder, T., Serbyn, M., & Berg, E. (2021). Unconventional
superconductivity in systems with annular Fermi surfaces: Application to rhombohedral
trilayer graphene. Physical Review Letters. American Physical Society.
https://doi.org/10.1103/physrevlett.127.247001'
chicago: 'Ghazaryan, Areg, Tobias Holder, Maksym Serbyn, and Erez Berg. “Unconventional
Superconductivity in Systems with Annular Fermi Surfaces: Application to Rhombohedral
Trilayer Graphene.” Physical Review Letters. American Physical Society,
2021. https://doi.org/10.1103/physrevlett.127.247001.'
ieee: 'A. Ghazaryan, T. Holder, M. Serbyn, and E. Berg, “Unconventional superconductivity
in systems with annular Fermi surfaces: Application to rhombohedral trilayer graphene,”
Physical Review Letters, vol. 127, no. 24. American Physical Society, 2021.'
ista: 'Ghazaryan A, Holder T, Serbyn M, Berg E. 2021. Unconventional superconductivity
in systems with annular Fermi surfaces: Application to rhombohedral trilayer graphene.
Physical Review Letters. 127(24), 247001.'
mla: 'Ghazaryan, Areg, et al. “Unconventional Superconductivity in Systems with
Annular Fermi Surfaces: Application to Rhombohedral Trilayer Graphene.” Physical
Review Letters, vol. 127, no. 24, 247001, American Physical Society, 2021,
doi:10.1103/physrevlett.127.247001.'
short: A. Ghazaryan, T. Holder, M. Serbyn, E. Berg, Physical Review Letters 127
(2021).
date_created: 2021-12-10T07:51:33Z
date_published: 2021-12-09T00:00:00Z
date_updated: 2023-08-14T13:19:13Z
day: '09'
department:
- _id: MaSe
doi: 10.1103/physrevlett.127.247001
ec_funded: 1
external_id:
arxiv:
- '2109.00011'
isi:
- '000923819400004'
intvolume: ' 127'
isi: 1
issue: '24'
keyword:
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2109.00011
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
link:
- description: News on IST Webpage
relation: press_release
url: https://ist.ac.at/en/news/resolving-the-puzzles-of-graphene-superconductivity/
scopus_import: '1'
status: public
title: 'Unconventional superconductivity in systems with annular Fermi surfaces: Application
to rhombohedral trilayer graphene'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 127
year: '2021'
...
---
_id: '10534'
abstract:
- lang: eng
text: For many years, fullerene derivatives have been the main n-type material of
organic electronics and optoelectronics. Recently, fullerene derivatives functionalized
with ethylene glycol (EG) side chains have been showing important properties such
as enhanced dielectric constants, facile doping and enhanced self-assembly capabilities.
Here, we have prepared field-effect transistors using a series of these fullerene
derivatives equipped with EG side chains of different lengths. Transport data
show the beneficial effect of increasing the EG side chain. In order to understand
the material properties, full structural determination of these fullerene derivatives
has been achieved by coupling the X-ray data with molecular dynamics (MD) simulations.
The increase in transport properties is paired with the formation of extended
layered structures, efficient molecular packing and an increase in the crystallite
alignment. The layer-like structure is composed of conducting layers, containing
of closely packed C60 balls approaching the inter-distance of 1 nm, that are separated
by well-defined EG layers, where the EG chains are rather splayed with the chain
direction almost perpendicular to the layer normal. Such a layered structure appears
highly ordered and highly aligned with the C60 planes oriented parallel to the
substrate in the thin film configuration. The order inside the thin film increases
with the EG chain length, allowing the systems to achieve mobilities as high as
0.053 cm2 V−1 s−1. Our work elucidates the structure of these interesting semiconducting
organic molecules and shows that the synergistic use of X-ray structural analysis
and MD simulations is a powerful tool to identify the structure of thin organic
films for optoelectronic applications.
acknowledgement: J. D. gratefully acknowledges the China Scholarship Council (CSC
No. 201606340158) for supporting his PhD studies. S. S. thanks J. Antoja-Lleonart
for insightful discussions on simulating the X-ray diffraction patterns. Part of
the work was sponsored by NWO Exact and Natural Sciences for the use of supercomputer
facilities (Contract no. 17197 7095). Regarding S. S., R. A., R. W. A. H., J. C.
H., and M. A. L., this is a publication by the FOM Focus Group “Next Generation
Organic Photovoltaics”, participating in the Dutch Institute for Fundamental Energy
Research (DIFFER). The ESRF is acknowledged for providing the beamtime. J. D. and
G. P. are grateful to the BM26B staff for their great support during the beamtime.
M. A. L., D. M. B. are grateful for the financial support of the European Research
Council via a Starting Grant (HySPOD, No. 306983).
article_processing_charge: No
article_type: original
author:
- first_name: Jingjin
full_name: Dong, Jingjin
last_name: Dong
- first_name: Selim
full_name: Sami, Selim
last_name: Sami
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Riccardo
full_name: Alessandri, Riccardo
last_name: Alessandri
- first_name: Fatimeh
full_name: Jahani, Fatimeh
last_name: Jahani
- first_name: Li
full_name: Qiu, Li
last_name: Qiu
- first_name: Siewert J.
full_name: Marrink, Siewert J.
last_name: Marrink
- first_name: Remco W.A.
full_name: Havenith, Remco W.A.
last_name: Havenith
- first_name: Jan C.
full_name: Hummelen, Jan C.
last_name: Hummelen
- first_name: Maria A.
full_name: Loi, Maria A.
last_name: Loi
- first_name: Giuseppe
full_name: Portale, Giuseppe
last_name: Portale
citation:
ama: 'Dong J, Sami S, Balazs D, et al. Fullerene derivatives with oligoethylene-glycol
side chains: An investigation on the origin of their outstanding transport properties.
Journal of Materials Chemistry C. 2021;9(45):16217-16225. doi:10.1039/d1tc02753k'
apa: 'Dong, J., Sami, S., Balazs, D., Alessandri, R., Jahani, F., Qiu, L., … Portale,
G. (2021). Fullerene derivatives with oligoethylene-glycol side chains: An investigation
on the origin of their outstanding transport properties. Journal of Materials
Chemistry C. Royal Society of Chemistry. https://doi.org/10.1039/d1tc02753k'
chicago: 'Dong, Jingjin, Selim Sami, Daniel Balazs, Riccardo Alessandri, Fatimeh
Jahani, Li Qiu, Siewert J. Marrink, et al. “Fullerene Derivatives with Oligoethylene-Glycol
Side Chains: An Investigation on the Origin of Their Outstanding Transport Properties.”
Journal of Materials Chemistry C. Royal Society of Chemistry, 2021. https://doi.org/10.1039/d1tc02753k.'
ieee: 'J. Dong et al., “Fullerene derivatives with oligoethylene-glycol side
chains: An investigation on the origin of their outstanding transport properties,”
Journal of Materials Chemistry C, vol. 9, no. 45. Royal Society of Chemistry,
pp. 16217–16225, 2021.'
ista: 'Dong J, Sami S, Balazs D, Alessandri R, Jahani F, Qiu L, Marrink SJ, Havenith
RWA, Hummelen JC, Loi MA, Portale G. 2021. Fullerene derivatives with oligoethylene-glycol
side chains: An investigation on the origin of their outstanding transport properties.
Journal of Materials Chemistry C. 9(45), 16217–16225.'
mla: 'Dong, Jingjin, et al. “Fullerene Derivatives with Oligoethylene-Glycol Side
Chains: An Investigation on the Origin of Their Outstanding Transport Properties.”
Journal of Materials Chemistry C, vol. 9, no. 45, Royal Society of Chemistry,
2021, pp. 16217–25, doi:10.1039/d1tc02753k.'
short: J. Dong, S. Sami, D. Balazs, R. Alessandri, F. Jahani, L. Qiu, S.J. Marrink,
R.W.A. Havenith, J.C. Hummelen, M.A. Loi, G. Portale, Journal of Materials Chemistry
C 9 (2021) 16217–16225.
date_created: 2021-12-12T23:01:27Z
date_published: 2021-12-07T00:00:00Z
date_updated: 2023-08-17T06:18:44Z
day: '07'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1039/d1tc02753k
external_id:
isi:
- '000688135700001'
file:
- access_level: open_access
checksum: 6b73c214ce54a6894a5854b4364413d7
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-13T09:24:42Z
date_updated: 2021-12-13T09:24:42Z
file_id: '10538'
file_name: 2021_JMaterChemC_Dong.pdf
file_size: 4979390
relation: main_file
success: 1
file_date_updated: 2021-12-13T09:24:42Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '45'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 16217-16225
publication: Journal of Materials Chemistry C
publication_identifier:
eissn:
- 2050-7526
issn:
- 2050-7534
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Fullerene derivatives with oligoethylene-glycol side chains: An investigation
on the origin of their outstanding transport properties'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2021'
...
---
_id: '10533'
abstract:
- lang: eng
text: Flowering plants utilize small RNA molecules to guide DNA methyltransferases
to genomic sequences. This RNA-directed DNA methylation (RdDM) pathway preferentially
targets euchromatic transposable elements. However, RdDM is thought to be recruited
by methylation of histone H3 at lysine 9 (H3K9me), a hallmark of heterochromatin.
How RdDM is targeted to euchromatin despite an affinity for H3K9me is unclear.
Here we show that loss of histone H1 enhances heterochromatic RdDM, preferentially
at nucleosome linker DNA. Surprisingly, this does not require SHH1, the RdDM component
that binds H3K9me. Furthermore, H3K9me is dispensable for RdDM, as is CG DNA methylation.
Instead, we find that non-CG methylation is specifically associated with small
RNA biogenesis, and without H1 small RNA production quantitatively expands to
non-CG methylated loci. Our results demonstrate that H1 enforces the separation
of euchromatic and heterochromatic DNA methylation pathways by excluding the small
RNA-generating branch of RdDM from non-CG methylated heterochromatin.
acknowledgement: We thank X Feng for helpful comments on the manuscript. This work
was supported by a European Research Council grant MaintainMeth (725746) to DZ.
article_number: e72676
article_processing_charge: No
article_type: original
author:
- first_name: Jaemyung
full_name: Choi, Jaemyung
last_name: Choi
- first_name: David B
full_name: Lyons, David B
last_name: Lyons
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
citation:
ama: Choi J, Lyons DB, Zilberman D. Histone H1 prevents non-CG methylation-mediated
small RNA biogenesis in Arabidopsis heterochromatin. eLife. 2021;10. doi:10.7554/elife.72676
apa: Choi, J., Lyons, D. B., & Zilberman, D. (2021). Histone H1 prevents non-CG
methylation-mediated small RNA biogenesis in Arabidopsis heterochromatin. ELife.
eLife Sciences Publications. https://doi.org/10.7554/elife.72676
chicago: Choi, Jaemyung, David B Lyons, and Daniel Zilberman. “Histone H1 Prevents
Non-CG Methylation-Mediated Small RNA Biogenesis in Arabidopsis Heterochromatin.”
ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.72676.
ieee: J. Choi, D. B. Lyons, and D. Zilberman, “Histone H1 prevents non-CG methylation-mediated
small RNA biogenesis in Arabidopsis heterochromatin,” eLife, vol. 10. eLife
Sciences Publications, 2021.
ista: Choi J, Lyons DB, Zilberman D. 2021. Histone H1 prevents non-CG methylation-mediated
small RNA biogenesis in Arabidopsis heterochromatin. eLife. 10, e72676.
mla: Choi, Jaemyung, et al. “Histone H1 Prevents Non-CG Methylation-Mediated Small
RNA Biogenesis in Arabidopsis Heterochromatin.” ELife, vol. 10, e72676,
eLife Sciences Publications, 2021, doi:10.7554/elife.72676.
short: J. Choi, D.B. Lyons, D. Zilberman, ELife 10 (2021).
date_created: 2021-12-10T13:12:08Z
date_published: 2021-12-01T00:00:00Z
date_updated: 2023-08-17T06:21:08Z
day: '01'
ddc:
- '570'
department:
- _id: DaZi
doi: 10.7554/elife.72676
ec_funded: 1
external_id:
isi:
- '000754832000001'
pmid:
- '34850679'
file:
- access_level: open_access
checksum: 22ed4c55fb550f6da02ae55c359be651
content_type: application/pdf
creator: dernst
date_created: 2022-05-16T10:42:22Z
date_updated: 2022-05-16T10:42:22Z
file_id: '11384'
file_name: 2021_eLife_Choi.pdf
file_size: 2715200
relation: main_file
success: 1
file_date_updated: 2022-05-16T10:42:22Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- genetics and molecular biology
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 62935a00-2b32-11ec-9570-eff30fa39068
call_identifier: H2020
grant_number: '725746'
name: Quantitative analysis of DNA methylation maintenance with chromatin
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Histone H1 prevents non-CG methylation-mediated small RNA biogenesis in Arabidopsis
heterochromatin
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '10536'
abstract:
- lang: eng
text: TGFβ overexpression is commonly detected in cancer patients and correlates
with poor prognosis and metastasis. Cancer progression is often associated with
an enhanced recruitment of myeloid-derived cells to the tumor microenvironment.
Here we show that functional TGFβ-signaling in myeloid cells is required for metastasis
to the lungs and the liver. Myeloid-specific deletion of Tgfbr2 resulted in reduced
spontaneous lung metastasis, which was associated with a reduction of proinflammatory
cytokines in the metastatic microenvironment. Notably, CD8+ T cell depletion in
myeloid-specific Tgfbr2-deficient mice rescued lung metastasis. Myeloid-specific
Tgfbr2-deficiency resulted in reduced liver metastasis with an almost complete
absence of myeloid cells within metastatic foci. On contrary, an accumulation
of Tgfβ-responsive myeloid cells was associated with an increased recruitment
of monocytes and granulocytes and higher proinflammatory cytokine levels in control
mice. Monocytic cells isolated from metastatic livers of Tgfbr2-deficient mice
showed increased polarization towards the M1 phenotype, Tnfα and Il-1β expression,
reduced levels of M2 markers and reduced production of chemokines responsible
for myeloid-cell recruitment. No significant differences in Tgfβ levels were observed
at metastatic sites of any model. These data demonstrate that Tgfβ signaling in
monocytic myeloid cells suppresses CD8+ T cell activity during lung metastasis,
while these cells actively contribute to tumor growth during liver metastasis.
Thus, myeloid cells modulate metastasis through different mechanisms in a tissue-specific
manner.
acknowledgement: The authors acknowledge the assistance of the Laboratory Animal Services
Center (LASC) – UZH, Center for Microscopy and Image Analysis, and the Flow Cytometry
Center of the University of Zurich.
article_number: '765151'
article_processing_charge: No
article_type: original
author:
- first_name: Cristina
full_name: Stefanescu, Cristina
last_name: Stefanescu
- first_name: Merel
full_name: Van Gogh, Merel
last_name: Van Gogh
- first_name: Marko
full_name: Roblek, Marko
id: 3047D808-F248-11E8-B48F-1D18A9856A87
last_name: Roblek
orcid: 0000-0001-9588-1389
- first_name: Mathias
full_name: Heikenwalder, Mathias
last_name: Heikenwalder
- first_name: Lubor
full_name: Borsig, Lubor
last_name: Borsig
citation:
ama: Stefanescu C, Van Gogh M, Roblek M, Heikenwalder M, Borsig L. TGFβ signaling
in myeloid cells promotes lung and liver metastasis through different mechanisms.
Frontiers in Oncology. 2021;11. doi:10.3389/fonc.2021.765151
apa: Stefanescu, C., Van Gogh, M., Roblek, M., Heikenwalder, M., & Borsig, L.
(2021). TGFβ signaling in myeloid cells promotes lung and liver metastasis through
different mechanisms. Frontiers in Oncology. Frontiers. https://doi.org/10.3389/fonc.2021.765151
chicago: Stefanescu, Cristina, Merel Van Gogh, Marko Roblek, Mathias Heikenwalder,
and Lubor Borsig. “TGFβ Signaling in Myeloid Cells Promotes Lung and Liver Metastasis
through Different Mechanisms.” Frontiers in Oncology. Frontiers, 2021.
https://doi.org/10.3389/fonc.2021.765151.
ieee: C. Stefanescu, M. Van Gogh, M. Roblek, M. Heikenwalder, and L. Borsig, “TGFβ
signaling in myeloid cells promotes lung and liver metastasis through different
mechanisms,” Frontiers in Oncology, vol. 11. Frontiers, 2021.
ista: Stefanescu C, Van Gogh M, Roblek M, Heikenwalder M, Borsig L. 2021. TGFβ signaling
in myeloid cells promotes lung and liver metastasis through different mechanisms.
Frontiers in Oncology. 11, 765151.
mla: Stefanescu, Cristina, et al. “TGFβ Signaling in Myeloid Cells Promotes Lung
and Liver Metastasis through Different Mechanisms.” Frontiers in Oncology,
vol. 11, 765151, Frontiers, 2021, doi:10.3389/fonc.2021.765151.
short: C. Stefanescu, M. Van Gogh, M. Roblek, M. Heikenwalder, L. Borsig, Frontiers
in Oncology 11 (2021).
date_created: 2021-12-12T23:01:27Z
date_published: 2021-11-18T00:00:00Z
date_updated: 2023-08-17T06:20:32Z
day: '18'
ddc:
- '610'
department:
- _id: DaSi
doi: 10.3389/fonc.2021.765151
external_id:
isi:
- '000726603400001'
pmid:
- '34868988'
file:
- access_level: open_access
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content_type: application/pdf
creator: alisjak
date_created: 2021-12-13T13:32:37Z
date_updated: 2021-12-13T13:32:37Z
file_id: '10539'
file_name: 2021_Frontiers_Stefanescu.pdf
file_size: 9245199
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success: 1
file_date_updated: 2021-12-13T13:32:37Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Oncology
publication_identifier:
eissn:
- 2234-943X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: TGFβ signaling in myeloid cells promotes lung and liver metastasis through
different mechanisms
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2021'
...
---
_id: '10537'
abstract:
- lang: eng
text: We consider the quantum many-body evolution of a homogeneous Fermi gas in
three dimensions in the coupled semiclassical and mean-field scaling regime. We
study a class of initial data describing collective particle–hole pair excitations
on the Fermi ball. Using a rigorous version of approximate bosonization, we prove
that the many-body evolution can be approximated in Fock space norm by a quasi-free
bosonic evolution of the collective particle–hole excitations.
acknowledgement: NB was supported by Gruppo Nazionale per la Fisica Matematica (GNFM).
RS was supported by the European Research Council (ERC) under the European Union’s
Horizon 2020 research and innovation program (Grant Agreement No. 694227). PTN was
supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
under Germany’s Excellence Strategy (EXC-2111-390814868). MP was supported by the
European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation program (ERC StG MaMBoQ, Grant Agreement No. 802901). BS was supported
by the NCCR SwissMAP, the Swiss National Science Foundation through the Grant “Dynamical
and energetic properties of Bose-Einstein condensates,” and the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation program
through the ERC-AdG CLaQS (Grant Agreement No. 834782).
article_processing_charge: No
article_type: original
author:
- first_name: Niels P
full_name: Benedikter, Niels P
id: 3DE6C32A-F248-11E8-B48F-1D18A9856A87
last_name: Benedikter
orcid: 0000-0002-1071-6091
- first_name: Phan Thành
full_name: Nam, Phan Thành
last_name: Nam
- first_name: Marcello
full_name: Porta, Marcello
last_name: Porta
- first_name: Benjamin
full_name: Schlein, Benjamin
last_name: Schlein
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Benedikter NP, Nam PT, Porta M, Schlein B, Seiringer R. Bosonization of fermionic
many-body dynamics. Annales Henri Poincaré. 2021. doi:10.1007/s00023-021-01136-y
apa: Benedikter, N. P., Nam, P. T., Porta, M., Schlein, B., & Seiringer, R.
(2021). Bosonization of fermionic many-body dynamics. Annales Henri Poincaré.
Springer Nature. https://doi.org/10.1007/s00023-021-01136-y
chicago: Benedikter, Niels P, Phan Thành Nam, Marcello Porta, Benjamin Schlein,
and Robert Seiringer. “Bosonization of Fermionic Many-Body Dynamics.” Annales
Henri Poincaré. Springer Nature, 2021. https://doi.org/10.1007/s00023-021-01136-y.
ieee: N. P. Benedikter, P. T. Nam, M. Porta, B. Schlein, and R. Seiringer, “Bosonization
of fermionic many-body dynamics,” Annales Henri Poincaré. Springer Nature,
2021.
ista: Benedikter NP, Nam PT, Porta M, Schlein B, Seiringer R. 2021. Bosonization
of fermionic many-body dynamics. Annales Henri Poincaré.
mla: Benedikter, Niels P., et al. “Bosonization of Fermionic Many-Body Dynamics.”
Annales Henri Poincaré, Springer Nature, 2021, doi:10.1007/s00023-021-01136-y.
short: N.P. Benedikter, P.T. Nam, M. Porta, B. Schlein, R. Seiringer, Annales Henri
Poincaré (2021).
date_created: 2021-12-12T23:01:28Z
date_published: 2021-12-02T00:00:00Z
date_updated: 2023-08-17T06:19:14Z
day: '02'
department:
- _id: RoSe
doi: 10.1007/s00023-021-01136-y
ec_funded: 1
external_id:
arxiv:
- '2103.08224'
isi:
- '000725405700001'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2103.08224
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication: Annales Henri Poincaré
publication_identifier:
issn:
- 1424-0637
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bosonization of fermionic many-body dynamics
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2021'
...
---
_id: '10549'
abstract:
- lang: eng
text: We derive optimal-order homogenization rates for random nonlinear elliptic
PDEs with monotone nonlinearity in the uniformly elliptic case. More precisely,
for a random monotone operator on \mathbb {R}^d with stationary law (that is spatially
homogeneous statistics) and fast decay of correlations on scales larger than the
microscale \varepsilon >0, we establish homogenization error estimates of the
order \varepsilon in case d\geqq 3, and of the order \varepsilon |\log \varepsilon
|^{1/2} in case d=2. Previous results in nonlinear stochastic homogenization have
been limited to a small algebraic rate of convergence \varepsilon ^\delta . We
also establish error estimates for the approximation of the homogenized operator
by the method of representative volumes of the order (L/\varepsilon )^{-d/2} for
a representative volume of size L. Our results also hold in the case of systems
for which a (small-scale) C^{1,\alpha } regularity theory is available.
acknowledgement: Open access funding provided by Institute of Science and Technology
(IST Austria). SN acknowledges partial support by the Deutsche Forschungsgemeinschaft
(DFG, German Research Foundation) – project number 405009441.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
- first_name: Stefan
full_name: Neukamm, Stefan
last_name: Neukamm
citation:
ama: Fischer JL, Neukamm S. Optimal homogenization rates in stochastic homogenization
of nonlinear uniformly elliptic equations and systems. Archive for Rational
Mechanics and Analysis. 2021;242(1):343-452. doi:10.1007/s00205-021-01686-9
apa: Fischer, J. L., & Neukamm, S. (2021). Optimal homogenization rates in stochastic
homogenization of nonlinear uniformly elliptic equations and systems. Archive
for Rational Mechanics and Analysis. Springer Nature. https://doi.org/10.1007/s00205-021-01686-9
chicago: Fischer, Julian L, and Stefan Neukamm. “Optimal Homogenization Rates in
Stochastic Homogenization of Nonlinear Uniformly Elliptic Equations and Systems.”
Archive for Rational Mechanics and Analysis. Springer Nature, 2021. https://doi.org/10.1007/s00205-021-01686-9.
ieee: J. L. Fischer and S. Neukamm, “Optimal homogenization rates in stochastic
homogenization of nonlinear uniformly elliptic equations and systems,” Archive
for Rational Mechanics and Analysis, vol. 242, no. 1. Springer Nature, pp.
343–452, 2021.
ista: Fischer JL, Neukamm S. 2021. Optimal homogenization rates in stochastic homogenization
of nonlinear uniformly elliptic equations and systems. Archive for Rational Mechanics
and Analysis. 242(1), 343–452.
mla: Fischer, Julian L., and Stefan Neukamm. “Optimal Homogenization Rates in Stochastic
Homogenization of Nonlinear Uniformly Elliptic Equations and Systems.” Archive
for Rational Mechanics and Analysis, vol. 242, no. 1, Springer Nature, 2021,
pp. 343–452, doi:10.1007/s00205-021-01686-9.
short: J.L. Fischer, S. Neukamm, Archive for Rational Mechanics and Analysis 242
(2021) 343–452.
date_created: 2021-12-16T12:12:33Z
date_published: 2021-06-30T00:00:00Z
date_updated: 2023-08-17T06:23:21Z
day: '30'
ddc:
- '530'
department:
- _id: JuFi
doi: 10.1007/s00205-021-01686-9
external_id:
arxiv:
- '1908.02273'
isi:
- '000668431200001'
file:
- access_level: open_access
checksum: cc830b739aed83ca2e32c4e0ce266a4c
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-16T14:58:08Z
date_updated: 2021-12-16T14:58:08Z
file_id: '10558'
file_name: 2021_ArchRatMechAnalysis_Fischer.pdf
file_size: 1640121
relation: main_file
success: 1
file_date_updated: 2021-12-16T14:58:08Z
has_accepted_license: '1'
intvolume: ' 242'
isi: 1
issue: '1'
keyword:
- Mechanical Engineering
- Mathematics (miscellaneous)
- Analysis
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 343-452
publication: Archive for Rational Mechanics and Analysis
publication_identifier:
eissn:
- 1432-0673
issn:
- 0003-9527
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optimal homogenization rates in stochastic homogenization of nonlinear uniformly
elliptic equations and systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 242
year: '2021'
...
---
_id: '10409'
abstract:
- lang: eng
text: We show that Yao’s garbling scheme is adaptively indistinguishable for the
class of Boolean circuits of size S and treewidth w with only a SO(w) loss
in security. For instance, circuits with constant treewidth are as a result adaptively
indistinguishable with only a polynomial loss. This (partially) complements a
negative result of Applebaum et al. (Crypto 2013), which showed (assuming one-way
functions) that Yao’s garbling scheme cannot be adaptively simulatable. As main
technical contributions, we introduce a new pebble game that abstracts out our
security reduction and then present a pebbling strategy for this game where the
number of pebbles used is roughly O(δwlog(S)) , δ being the fan-out of the
circuit. The design of the strategy relies on separators, a graph-theoretic notion
with connections to circuit complexity. with only a SO(w) loss in security.
For instance, circuits with constant treewidth are as a result adaptively indistinguishable
with only a polynomial loss. This (partially) complements a negative result of
Applebaum et al. (Crypto 2013), which showed (assuming one-way functions) that
Yao’s garbling scheme cannot be adaptively simulatable. As main technical contributions,
we introduce a new pebble game that abstracts out our security reduction and then
present a pebbling strategy for this game where the number of pebbles used is
roughly O(δwlog(S)) , δ being the fan-out of the circuit. The design of the
strategy relies on separators, a graph-theoretic notion with connections to circuit
complexity.
acknowledgement: We are grateful to Daniel Wichs for helpful discussions on the landscape
of adaptive security of Yao’s garbling. We would also like to thank Crypto 2021
and TCC 2021 reviewers for their detailed review and suggestions, which helped improve
presentation considerably.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Chethan
full_name: Kamath Hosdurg, Chethan
id: 4BD3F30E-F248-11E8-B48F-1D18A9856A87
last_name: Kamath Hosdurg
- first_name: Karen
full_name: Klein, Karen
id: 3E83A2F8-F248-11E8-B48F-1D18A9856A87
last_name: Klein
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
citation:
ama: 'Kamath Hosdurg C, Klein K, Pietrzak KZ. On treewidth, separators and Yao’s
garbling. In: 19th International Conference. Vol 13043. Springer Nature;
2021:486-517. doi:10.1007/978-3-030-90453-1_17'
apa: 'Kamath Hosdurg, C., Klein, K., & Pietrzak, K. Z. (2021). On treewidth,
separators and Yao’s garbling. In 19th International Conference (Vol. 13043,
pp. 486–517). Raleigh, NC, United States: Springer Nature. https://doi.org/10.1007/978-3-030-90453-1_17'
chicago: Kamath Hosdurg, Chethan, Karen Klein, and Krzysztof Z Pietrzak. “On Treewidth,
Separators and Yao’s Garbling.” In 19th International Conference, 13043:486–517.
Springer Nature, 2021. https://doi.org/10.1007/978-3-030-90453-1_17.
ieee: C. Kamath Hosdurg, K. Klein, and K. Z. Pietrzak, “On treewidth, separators
and Yao’s garbling,” in 19th International Conference, Raleigh, NC, United
States, 2021, vol. 13043, pp. 486–517.
ista: 'Kamath Hosdurg C, Klein K, Pietrzak KZ. 2021. On treewidth, separators and
Yao’s garbling. 19th International Conference. TCC: Theory of Cryptography, LNCS,
vol. 13043, 486–517.'
mla: Kamath Hosdurg, Chethan, et al. “On Treewidth, Separators and Yao’s Garbling.”
19th International Conference, vol. 13043, Springer Nature, 2021, pp. 486–517,
doi:10.1007/978-3-030-90453-1_17.
short: C. Kamath Hosdurg, K. Klein, K.Z. Pietrzak, in:, 19th International Conference,
Springer Nature, 2021, pp. 486–517.
conference:
end_date: 2021-11-11
location: Raleigh, NC, United States
name: 'TCC: Theory of Cryptography'
start_date: 2021-11-08
date_created: 2021-12-05T23:01:43Z
date_published: 2021-11-04T00:00:00Z
date_updated: 2023-08-17T06:21:38Z
day: '04'
department:
- _id: KrPi
doi: 10.1007/978-3-030-90453-1_17
ec_funded: 1
external_id:
isi:
- '000728364000017'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2021/926
month: '11'
oa: 1
oa_version: Preprint
page: 486-517
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
publication: 19th International Conference
publication_identifier:
eissn:
- 1611-3349
isbn:
- 9-783-0309-0452-4
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '10044'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: On treewidth, separators and Yao’s garbling
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: '13043 '
year: '2021'
...
---
_id: '10545'
abstract:
- lang: eng
text: Classical models with complex energy landscapes represent a perspective avenue
for the near-term application of quantum simulators. Until now, many theoretical
works studied the performance of quantum algorithms for models with a unique ground
state. However, when the classical problem is in a so-called clustering phase,
the ground state manifold is highly degenerate. As an example, we consider a 3-XORSAT
model defined on simple hypergraphs. The degeneracy of classical ground state
manifold translates into the emergence of an extensive number of Z2 symmetries,
which remain intact even in the presence of a quantum transverse magnetic field.
We establish a general duality approach that restricts the quantum problem to
a given sector of conserved Z2 charges and use it to study how the outcome of
the quantum adiabatic algorithm depends on the hypergraph geometry. We show that
the tree hypergraph which corresponds to a classically solvable instance of the
3-XORSAT problem features a constant gap, whereas the closed hypergraph encounters
a second-order phase transition with a gap vanishing as a power-law in the problem
size. The duality developed in this work provides a practical tool for studies
of quantum models with classically degenerate energy manifold and reveals potential
connections between glasses and gauge theories.
acknowledgement: We would like to thank S. De Nicola, A. Michaidilis, T. Gulden, Y.
Nez-Fernndez, P. Brighi, and S. Sack for fruitful discussions and valuable feedback
on the manuscript. M.S. acknowledges useful discussions with E. Altman, L. Cugliandolo,
and C. Laumann. We acknowledge support from the European Research Council (ERC)
under the European Union's Horizon 2020 Research and Innovation Programme Grant
Agreement No. 850899.
article_number: '062423'
article_processing_charge: No
article_type: original
author:
- first_name: Raimel A
full_name: Medina Ramos, Raimel A
id: CE680B90-D85A-11E9-B684-C920E6697425
last_name: Medina Ramos
orcid: 0000-0002-5383-2869
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Medina Ramos RA, Serbyn M. Duality approach to quantum annealing of the 3-variable
exclusive-or satisfiability problem (3-XORSAT). Physical Review A. 2021;104(6).
doi:10.1103/physreva.104.062423
apa: Medina Ramos, R. A., & Serbyn, M. (2021). Duality approach to quantum annealing
of the 3-variable exclusive-or satisfiability problem (3-XORSAT). Physical
Review A. American Physical Society. https://doi.org/10.1103/physreva.104.062423
chicago: Medina Ramos, Raimel A, and Maksym Serbyn. “Duality Approach to Quantum
Annealing of the 3-Variable Exclusive-or Satisfiability Problem (3-XORSAT).” Physical
Review A. American Physical Society, 2021. https://doi.org/10.1103/physreva.104.062423.
ieee: R. A. Medina Ramos and M. Serbyn, “Duality approach to quantum annealing of
the 3-variable exclusive-or satisfiability problem (3-XORSAT),” Physical Review
A, vol. 104, no. 6. American Physical Society, 2021.
ista: Medina Ramos RA, Serbyn M. 2021. Duality approach to quantum annealing of
the 3-variable exclusive-or satisfiability problem (3-XORSAT). Physical Review
A. 104(6), 062423.
mla: Medina Ramos, Raimel A., and Maksym Serbyn. “Duality Approach to Quantum Annealing
of the 3-Variable Exclusive-or Satisfiability Problem (3-XORSAT).” Physical
Review A, vol. 104, no. 6, 062423, American Physical Society, 2021, doi:10.1103/physreva.104.062423.
short: R.A. Medina Ramos, M. Serbyn, Physical Review A 104 (2021).
date_created: 2021-12-14T20:46:07Z
date_published: 2021-12-14T00:00:00Z
date_updated: 2023-08-17T06:22:49Z
day: '14'
department:
- _id: MaSe
doi: 10.1103/physreva.104.062423
ec_funded: 1
external_id:
arxiv:
- '2106.06344'
isi:
- '000753659200004'
intvolume: ' 104'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2106.06344
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review A
publication_identifier:
eissn:
- 2469-9934
issn:
- 2469-9926
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Duality approach to quantum annealing of the 3-variable exclusive-or satisfiability
problem (3-XORSAT)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 104
year: '2021'
...
---
_id: '10554'
abstract:
- lang: eng
text: 'We present DAG-Rider, the first asynchronous Byzantine Atomic Broadcast protocol
that achieves optimal resilience, optimal amortized communication complexity,
and optimal time complexity. DAG-Rider is post-quantum safe and ensures that all
values proposed by correct processes eventually get delivered. We construct DAG-Rider
in two layers: In the first layer, processes reliably broadcast their proposals
and build a structured Directed Acyclic Graph (DAG) of the communication among
them. In the second layer, processes locally observe their DAGs and totally order
all proposals with no extra communication.'
acknowledgement: "Oded Naor is grateful to the Technion Hiroshi Fujiwara Cyber-Security
Research Center for providing a research grant. Part of Oded’s work was done while
at Novi Research. This work was funded by the Novi team at Facebook. We also wish
to thank the Novi Research team for valuable feedback, and in particular George
Danezis, Alberto Sonnino, and Dahlia Malkhi.\r\n"
article_processing_charge: No
author:
- first_name: Idit
full_name: Keidar, Idit
last_name: Keidar
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Oded
full_name: Naor, Oded
last_name: Naor
- first_name: Alexander
full_name: Spiegelman, Alexander
last_name: Spiegelman
citation:
ama: 'Keidar I, Kokoris Kogias E, Naor O, Spiegelman A. All You Need is DAG. In:
Proceedings of the 2021 ACM Symposium on Principles of Distributed Computing.
Association for Computing Machinery; 2021:165-175. doi:10.1145/3465084.3467905'
apa: 'Keidar, I., Kokoris Kogias, E., Naor, O., & Spiegelman, A. (2021). All
You Need is DAG. In Proceedings of the 2021 ACM Symposium on Principles of
Distributed Computing (pp. 165–175). Virtual, Italy: Association for Computing
Machinery. https://doi.org/10.1145/3465084.3467905'
chicago: Keidar, Idit, Eleftherios Kokoris Kogias, Oded Naor, and Alexander Spiegelman.
“All You Need Is DAG.” In Proceedings of the 2021 ACM Symposium on Principles
of Distributed Computing, 165–75. Association for Computing Machinery, 2021.
https://doi.org/10.1145/3465084.3467905.
ieee: I. Keidar, E. Kokoris Kogias, O. Naor, and A. Spiegelman, “All You Need is
DAG,” in Proceedings of the 2021 ACM Symposium on Principles of Distributed
Computing, Virtual, Italy, 2021, pp. 165–175.
ista: 'Keidar I, Kokoris Kogias E, Naor O, Spiegelman A. 2021. All You Need is DAG.
Proceedings of the 2021 ACM Symposium on Principles of Distributed Computing.
PODC: Principles of Distributed Computing, 165–175.'
mla: Keidar, Idit, et al. “All You Need Is DAG.” Proceedings of the 2021 ACM
Symposium on Principles of Distributed Computing, Association for Computing
Machinery, 2021, pp. 165–75, doi:10.1145/3465084.3467905.
short: I. Keidar, E. Kokoris Kogias, O. Naor, A. Spiegelman, in:, Proceedings of
the 2021 ACM Symposium on Principles of Distributed Computing, Association for
Computing Machinery, 2021, pp. 165–175.
conference:
end_date: 2021-07-30
location: Virtual, Italy
name: 'PODC: Principles of Distributed Computing'
start_date: 2021-07-26
date_created: 2021-12-16T13:21:13Z
date_published: 2021-07-21T00:00:00Z
date_updated: 2023-08-17T06:24:44Z
day: '21'
department:
- _id: ElKo
doi: 10.1145/3465084.3467905
external_id:
arxiv:
- '2102.08325'
isi:
- '000744439800016'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2102.08325
month: '07'
oa: 1
oa_version: Preprint
page: 165-175
publication: Proceedings of the 2021 ACM Symposium on Principles of Distributed Computing
publication_identifier:
isbn:
- 978-1-4503-8548-0
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: All You Need is DAG
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2021'
...
---
_id: '10568'
abstract:
- lang: eng
text: Genetic adaptation and phenotypic plasticity facilitate the migration into
new habitats and enable organisms to cope with a rapidly changing environment.
In contrast to genetic adaptation that spans multiple generations as an evolutionary
process, phenotypic plasticity allows acclimation within the life-time of an organism.
Genetic adaptation and phenotypic plasticity are usually studied in isolation,
however, only by including their interactive impact, we can understand acclimation
and adaptation in nature. We aimed to explore the contribution of adaptation and
plasticity in coping with an abiotic (salinity) and a biotic (Vibrio bacteria)
stressor using six different populations of the broad-nosed pipefish Syngnathus
typhle that originated from either high [14–17 Practical Salinity Unit (PSU)]
or low (7–11 PSU) saline environments along the German coastline of the Baltic
Sea. We exposed wild caught animals, to either high (15 PSU) or low (7 PSU) salinity,
representing native and novel salinity conditions and allowed animals to mate.
After male pregnancy, offspring was split and each half was exposed to one of
the two salinities and infected with Vibrio alginolyticus bacteria that were evolved
at either of the two salinities in a fully reciprocal design. We investigated
life-history traits of fathers and expression of 47 target genes in mothers and
offspring. Pregnant males originating from high salinity exposed to low salinity
were highly susceptible to opportunistic fungi infections resulting in decreased
offspring size and number. In contrast, no signs of fungal infection were identified
in fathers originating from low saline conditions suggesting that genetic adaptation
has the potential to overcome the challenges encountered at low salinity. Offspring
from parents with low saline origin survived better at low salinity suggesting
genetic adaptation to low salinity. In addition, gene expression analyses of juveniles
indicated patterns of local adaptation, trans-generational plasticity and developmental
plasticity. In conclusion, our study suggests that pipefish are locally adapted
to the low salinity in their environment, however, they are retaining phenotypic
plasticity, which allows them to also cope with ancestral salinity levels and
prevailing pathogens.
acknowledgement: We are grateful for the help of Kristina Dauven, Andreas Ebner, Janina
Röckner, and Paulina Urban for fish collection in the field and fish maintenance.
Furthermore, we thank Fabian Wendt for setting up the aquaria system and Tatjana
Liese, Paulina Urban, Jakob Gismann, and Thorsten Reusch for support with DNA extraction
and analysis of pipefish population structure. The authors acknowledge support of
Isabel Tanger, Agnes Piecyk, Jonas Müller, Grace Walls, Sebastian Albrecht, Julia
Böge, and Julia Stefanschitz for their support in preparing cDNA and running of
Fluidigm chips. A special thank goes to Diana Gill for general lab support, ordering
materials and just being the good spirit of our molecular lab, to Till Bayer for
bioinformatics support and to Melanie Heckwolf for fruitful discussion and feedback
on the manuscript. HG is very grateful for inspirational office space with ocean
view provided by Lisa Hentschel and family. This manuscript has been released as
a pre-print at BIORXIV.
article_number: '626442'
article_processing_charge: No
article_type: original
author:
- first_name: Henry
full_name: Goehlich, Henry
last_name: Goehlich
- first_name: Linda
full_name: Sartoris, Linda
id: 2B9284CA-F248-11E8-B48F-1D18A9856A87
last_name: Sartoris
- first_name: Kim-Sara
full_name: Wagner, Kim-Sara
last_name: Wagner
- first_name: Carolin C.
full_name: Wendling, Carolin C.
last_name: Wendling
- first_name: Olivia
full_name: Roth, Olivia
last_name: Roth
citation:
ama: Goehlich H, Sartoris L, Wagner K-S, Wendling CC, Roth O. Pipefish locally adapted
to low salinity in the Baltic Sea retain phenotypic plasticity to cope with ancestral
salinity levels. Frontiers in Ecology and Evolution. 2021;9. doi:10.3389/fevo.2021.626442
apa: Goehlich, H., Sartoris, L., Wagner, K.-S., Wendling, C. C., & Roth, O.
(2021). Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic
plasticity to cope with ancestral salinity levels. Frontiers in Ecology and
Evolution. Frontiers Media. https://doi.org/10.3389/fevo.2021.626442
chicago: Goehlich, Henry, Linda Sartoris, Kim-Sara Wagner, Carolin C. Wendling,
and Olivia Roth. “Pipefish Locally Adapted to Low Salinity in the Baltic Sea Retain
Phenotypic Plasticity to Cope with Ancestral Salinity Levels.” Frontiers in
Ecology and Evolution. Frontiers Media, 2021. https://doi.org/10.3389/fevo.2021.626442.
ieee: H. Goehlich, L. Sartoris, K.-S. Wagner, C. C. Wendling, and O. Roth, “Pipefish
locally adapted to low salinity in the Baltic Sea retain phenotypic plasticity
to cope with ancestral salinity levels,” Frontiers in Ecology and Evolution,
vol. 9. Frontiers Media, 2021.
ista: Goehlich H, Sartoris L, Wagner K-S, Wendling CC, Roth O. 2021. Pipefish locally
adapted to low salinity in the Baltic Sea retain phenotypic plasticity to cope
with ancestral salinity levels. Frontiers in Ecology and Evolution. 9, 626442.
mla: Goehlich, Henry, et al. “Pipefish Locally Adapted to Low Salinity in the Baltic
Sea Retain Phenotypic Plasticity to Cope with Ancestral Salinity Levels.” Frontiers
in Ecology and Evolution, vol. 9, 626442, Frontiers Media, 2021, doi:10.3389/fevo.2021.626442.
short: H. Goehlich, L. Sartoris, K.-S. Wagner, C.C. Wendling, O. Roth, Frontiers
in Ecology and Evolution 9 (2021).
date_created: 2021-12-20T07:53:19Z
date_published: 2021-03-25T00:00:00Z
date_updated: 2023-08-17T06:27:22Z
day: '25'
ddc:
- '597'
department:
- _id: SyCr
doi: 10.3389/fevo.2021.626442
external_id:
isi:
- '000637736300001'
file:
- access_level: open_access
checksum: 8d6e2b767bb0240a9b5a3a3555be51fd
content_type: application/pdf
creator: alisjak
date_created: 2021-12-20T10:44:20Z
date_updated: 2021-12-20T10:44:20Z
file_id: '10572'
file_name: 2021_Frontiers_Goehlich.pdf
file_size: 3175085
relation: main_file
success: 1
file_date_updated: 2021-12-20T10:44:20Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
keyword:
- ecology
- evolution
- behavior and systematics
- trans-generational plasticity
- genetic adaptation
- local adaptation
- phenotypic plasticity
- Baltic Sea
- climate change
- salinity
- syngnathids
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Frontiers in Ecology and Evolution
publication_identifier:
issn:
- 2296-701X
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic
plasticity to cope with ancestral salinity levels
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2021'
...
---
_id: '10586'
abstract:
- lang: eng
text: A facile approach for developing an interfacial solar evaporator by heat localization
of solar-thermal energy conversion at water-air liquid composed by in-situ polymerization
of Fe2O3 nanoparticles (Fe2O3@PPy) deposited over a facial sponge is proposed.
The demonstrated system consists of a floating solar receiver having a vertically
cross-linked microchannel for wicking up saline water. The in situ polymerized
Fe2O3@PPy interfacial layer promotes diffuse reflection and its rough black surface
allows Omni-directional solar absorption (94%) and facilitates efficient thermal
localization at the water/air interface and offers a defect-rich surface to promote
heat localization (41.9 °C) and excellent thermal management due to cellulosic
content. The self-floating composite foam reveals continuous vapors generation
at a rate of 1.52 kg m−2 h−1 under one 1 kW m−2 and profound evaporating efficiency
(95%) without heat losses that dissipates in its surroundings. Indeed, long-term
evaporation experiments reveal the negligible disparity in continuous evaporation
rate (33.84 kg m−2/8.3 h) receiving two sun solar intensity, and ensures the stability
of the device under intense seawater conditions synchronized with excellent salt
rejection potential. More importantly, Raman spectroscopy investigation validates
the orange dye rejection via Fe2O3@PPy solar evaporator. The combined advantages
of high efficiency, self-floating capability, multimedia rejection, low cost,
and this configuration are promising for producing large-scale solar steam generating
systems appropriate for commercial clean water yield due to their scalable fabrication.
acknowledgement: The authors extend their appreciation to King Saud University for
funding this work through Researchers Supporting Project number (RSP-2021/387),
King Saud University, Riyadh, Saudi Arabia.
alternative_title:
- Hybrid and Composite Crystalline Materials
article_number: '1509'
article_processing_charge: No
article_type: original
author:
- first_name: Yuzheng
full_name: Lu, Yuzheng
last_name: Lu
- first_name: Naila
full_name: Arshad, Naila
last_name: Arshad
- first_name: Muhammad Sultan
full_name: Irshad, Muhammad Sultan
last_name: Irshad
- first_name: Iftikhar
full_name: Ahmed, Iftikhar
last_name: Ahmed
- first_name: Shafiq
full_name: Ahmad, Shafiq
last_name: Ahmad
- first_name: Lina Abdullah
full_name: Alshahrani, Lina Abdullah
last_name: Alshahrani
- first_name: Muhammad
full_name: Yousaf, Muhammad
last_name: Yousaf
- first_name: Abdelaty Edrees
full_name: Sayed, Abdelaty Edrees
last_name: Sayed
- first_name: Muhammad
full_name: Nauman, Muhammad
id: 32c21954-2022-11eb-9d5f-af9f93c24e71
last_name: Nauman
orcid: 0000-0002-2111-4846
citation:
ama: Lu Y, Arshad N, Irshad MS, et al. Fe2O3 nanoparticles deposited over self-floating
facial sponge for facile interfacial seawater solar desalination. Crystals.
2021;11(12). doi:10.3390/cryst11121509
apa: Lu, Y., Arshad, N., Irshad, M. S., Ahmed, I., Ahmad, S., Alshahrani, L. A.,
… Nauman, M. (2021). Fe2O3 nanoparticles deposited over self-floating facial sponge
for facile interfacial seawater solar desalination. Crystals. MDPI. https://doi.org/10.3390/cryst11121509
chicago: Lu, Yuzheng, Naila Arshad, Muhammad Sultan Irshad, Iftikhar Ahmed, Shafiq
Ahmad, Lina Abdullah Alshahrani, Muhammad Yousaf, Abdelaty Edrees Sayed, and Muhammad
Nauman. “Fe2O3 Nanoparticles Deposited over Self-Floating Facial Sponge for Facile
Interfacial Seawater Solar Desalination.” Crystals. MDPI, 2021. https://doi.org/10.3390/cryst11121509.
ieee: Y. Lu et al., “Fe2O3 nanoparticles deposited over self-floating facial
sponge for facile interfacial seawater solar desalination,” Crystals, vol.
11, no. 12. MDPI, 2021.
ista: Lu Y, Arshad N, Irshad MS, Ahmed I, Ahmad S, Alshahrani LA, Yousaf M, Sayed
AE, Nauman M. 2021. Fe2O3 nanoparticles deposited over self-floating facial sponge
for facile interfacial seawater solar desalination. Crystals. 11(12), 1509.
mla: Lu, Yuzheng, et al. “Fe2O3 Nanoparticles Deposited over Self-Floating Facial
Sponge for Facile Interfacial Seawater Solar Desalination.” Crystals, vol.
11, no. 12, 1509, MDPI, 2021, doi:10.3390/cryst11121509.
short: Y. Lu, N. Arshad, M.S. Irshad, I. Ahmed, S. Ahmad, L.A. Alshahrani, M. Yousaf,
A.E. Sayed, M. Nauman, Crystals 11 (2021).
date_created: 2022-01-02T23:01:34Z
date_published: 2021-12-03T00:00:00Z
date_updated: 2023-08-17T06:31:20Z
day: '03'
ddc:
- '620'
department:
- _id: KiMo
doi: 10.3390/cryst11121509
external_id:
isi:
- '000736602200001'
file:
- access_level: open_access
checksum: 668e9d777608ce0a3bc2e305133bd06b
content_type: application/pdf
creator: alisjak
date_created: 2022-01-03T09:46:53Z
date_updated: 2022-01-03T09:46:53Z
file_id: '10591'
file_name: 2021_Crystals_Yuzheng.pdf
file_size: 4569639
relation: main_file
success: 1
file_date_updated: 2022-01-03T09:46:53Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Crystals
publication_identifier:
eissn:
- 2073-4352
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fe2O3 nanoparticles deposited over self-floating facial sponge for facile interfacial
seawater solar desalination
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2021'
...
---
_id: '10569'
abstract:
- lang: eng
text: 'For animals to survive until reproduction, it is crucial that juveniles successfully
detect potential predators and respond with appropriate behavior. The recognition
of cues originating from predators can be innate or learned. Cues of various modalities
might be used alone or in multi-modal combinations to detect and distinguish predators
but studies investigating multi-modal integration in predator avoidance are scarce.
Here, we used wild, naive tadpoles of the Neotropical poison frog Allobates femoralis
( Boulenger, 1884) to test their reaction to cues with two modalities from two
different sympatrically occurring potential predators: heterospecific predatory
Dendrobates tinctorius tadpoles and dragonfly larvae. We presented A. femoralis
tadpoles with olfactory or visual cues, or a combination of the two, and compared
their reaction to a water control in a between-individual design. In our trials,
A. femoralis tadpoles reacted to multi-modal stimuli (a combination of visual
and chemical information) originating from dragonfly larvae with avoidance but
showed no reaction to uni-modal cues or cues from heterospecific tadpoles. In
addition, visual cues from conspecifics increased swimming activity while cues
from predators had no effect on tadpole activity. Our results show that A. femoralis
tadpoles can innately recognize some predators and probably need both visual and
chemical information to effectively avoid them. This is the first study looking
at anti-predator behavior in poison frog tadpoles. We discuss how parental care
might influence the expression of predator avoidance responses in tadpoles.'
acknowledgement: We are grateful to Véronique Helfer, Walter Hödl, Lisa Schretzmeyer
and Julia Wotke, who assisted with fieldwork in French Guiana. This work was supported
by the Austrian Science Fund (FWF) [P24788, T699 and P31518 to E.R.; P33728 to M.R.;
J3827 to Thomas Bugnyar, Tecumseh Fitch and Ludwig Huber]; and by the Austrian Bundesministerium
für Wissenschaft, Forschung und Wirtschaft [IS761001 to J.O. (Tecumseh Fitch, Thomas
Bugnyar and Ludwig Huber)]. A.P. was supported by the European Union's Horizon 2020
research and innovation programme under the Marie Sklodowska-Curie grant agreement
no. 835530. S.A.R. was supported by the HT faculty, Lund University. We thank the
CNRS Nouragues Ecological Research Station, which benefited from the ‘Investissement
d'Avenir’ grants managed by the Agence Nationale de la Recherche (AnaEE France ANR-11-INBS-0001;
Labex CEBA ANR-10-LABX-25-01). Open access funding provided by University of Vienna.
Deposited in PMC for immediate release.
article_number: jeb243647
article_processing_charge: No
article_type: original
author:
- first_name: B
full_name: Szabo, B
last_name: Szabo
- first_name: R
full_name: Mangione, R
last_name: Mangione
- first_name: M
full_name: Rath, M
last_name: Rath
- first_name: A
full_name: Pašukonis, A
last_name: Pašukonis
- first_name: SA
full_name: Reber, SA
last_name: Reber
- first_name: Jinook
full_name: Oh, Jinook
id: 403169A4-080F-11EA-9993-BF3F3DDC885E
last_name: Oh
orcid: 0000-0001-7425-2372
- first_name: M
full_name: Ringler, M
last_name: Ringler
- first_name: E
full_name: Ringler, E
last_name: Ringler
citation:
ama: Szabo B, Mangione R, Rath M, et al. Naïve poison frog tadpoles use bi-modal
cues to avoid insect predators but not heterospecific predatory tadpoles. Journal
of Experimental Biology. 2021;224(24). doi:10.1242/jeb.243647
apa: Szabo, B., Mangione, R., Rath, M., Pašukonis, A., Reber, S., Oh, J., … Ringler,
E. (2021). Naïve poison frog tadpoles use bi-modal cues to avoid insect predators
but not heterospecific predatory tadpoles. Journal of Experimental Biology.
The Company of Biologists. https://doi.org/10.1242/jeb.243647
chicago: Szabo, B, R Mangione, M Rath, A Pašukonis, SA Reber, Jinook Oh, M Ringler,
and E Ringler. “Naïve Poison Frog Tadpoles Use Bi-Modal Cues to Avoid Insect Predators
but Not Heterospecific Predatory Tadpoles.” Journal of Experimental Biology.
The Company of Biologists, 2021. https://doi.org/10.1242/jeb.243647.
ieee: B. Szabo et al., “Naïve poison frog tadpoles use bi-modal cues to avoid
insect predators but not heterospecific predatory tadpoles,” Journal of Experimental
Biology, vol. 224, no. 24. The Company of Biologists, 2021.
ista: Szabo B, Mangione R, Rath M, Pašukonis A, Reber S, Oh J, Ringler M, Ringler
E. 2021. Naïve poison frog tadpoles use bi-modal cues to avoid insect predators
but not heterospecific predatory tadpoles. Journal of Experimental Biology. 224(24),
jeb243647.
mla: Szabo, B., et al. “Naïve Poison Frog Tadpoles Use Bi-Modal Cues to Avoid Insect
Predators but Not Heterospecific Predatory Tadpoles.” Journal of Experimental
Biology, vol. 224, no. 24, jeb243647, The Company of Biologists, 2021, doi:10.1242/jeb.243647.
short: B. Szabo, R. Mangione, M. Rath, A. Pašukonis, S. Reber, J. Oh, M. Ringler,
E. Ringler, Journal of Experimental Biology 224 (2021).
date_created: 2021-12-20T07:54:22Z
date_published: 2021-12-16T00:00:00Z
date_updated: 2023-08-17T06:26:15Z
day: '16'
ddc:
- '573'
department:
- _id: SyCr
doi: 10.1242/jeb.243647
external_id:
isi:
- '000738259300013'
pmid:
- '34845497'
file:
- access_level: open_access
checksum: 75d13a5ec8e3b90e3bc02bd8a9c17eef
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-20T10:14:14Z
date_updated: 2021-12-20T10:14:14Z
file_id: '10571'
file_name: 2021_JExpBio_Szabo.pdf
file_size: 607096
relation: main_file
success: 1
file_date_updated: 2021-12-20T10:14:14Z
has_accepted_license: '1'
intvolume: ' 224'
isi: 1
issue: '24'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Experimental Biology
publication_identifier:
eissn:
- 1477-9145
issn:
- 0022-0949
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
status: public
title: Naïve poison frog tadpoles use bi-modal cues to avoid insect predators but
not heterospecific predatory tadpoles
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 224
year: '2021'
...
---
_id: '10575'
abstract:
- lang: eng
text: The choice of the boundary conditions in mechanical problems has to reflect
the interaction of the considered material with the surface. Still the assumption
of the no-slip condition is preferred in order to avoid boundary terms in the
analysis and slipping effects are usually overlooked. Besides the “static slip
models”, there are phenomena that are not accurately described by them, e.g. at
the moment when the slip changes rapidly, the wall shear stress and the slip can
exhibit a sudden overshoot and subsequent relaxation. When these effects become
significant, the so-called dynamic slip phenomenon occurs. We develop a mathematical
analysis of Navier–Stokes-like problems with a dynamic slip boundary condition,
which requires a proper generalization of the Gelfand triplet and the corresponding
function space setting.
acknowledgement: The research of A. Abbatiello is supported by Einstein Foundation,
Berlin. A. Abbatiello is also member of the Italian National Group for the Mathematical
Physics (GNFM) of INdAM. M. Bulíček acknowledges the support of the project No.
20-11027X financed by Czech Science Foundation (GACR). M. Bulíček is member of the
Jindřich Nečas Center for Mathematical Modelling. E. Maringová acknowledges support
from Charles University Research program UNCE/SCI/023, the grant SVV-2020-260583
by the Ministry of Education, Youth and Sports, Czech Republic and from the Austrian
Science Fund (FWF), grants P30000, W1245, and F65.
article_processing_charge: No
article_type: original
author:
- first_name: Anna
full_name: Abbatiello, Anna
last_name: Abbatiello
- first_name: Miroslav
full_name: Bulíček, Miroslav
last_name: Bulíček
- first_name: Erika
full_name: Maringová, Erika
id: dbabca31-66eb-11eb-963a-fb9c22c880b4
last_name: Maringová
citation:
ama: Abbatiello A, Bulíček M, Maringová E. On the dynamic slip boundary condition
for Navier-Stokes-like problems. Mathematical Models and Methods in Applied
Sciences. 2021;31(11):2165-2212. doi:10.1142/S0218202521500470
apa: Abbatiello, A., Bulíček, M., & Maringová, E. (2021). On the dynamic slip
boundary condition for Navier-Stokes-like problems. Mathematical Models and
Methods in Applied Sciences. World Scientific Publishing. https://doi.org/10.1142/S0218202521500470
chicago: Abbatiello, Anna, Miroslav Bulíček, and Erika Maringová. “On the Dynamic
Slip Boundary Condition for Navier-Stokes-like Problems.” Mathematical Models
and Methods in Applied Sciences. World Scientific Publishing, 2021. https://doi.org/10.1142/S0218202521500470.
ieee: A. Abbatiello, M. Bulíček, and E. Maringová, “On the dynamic slip boundary
condition for Navier-Stokes-like problems,” Mathematical Models and Methods
in Applied Sciences, vol. 31, no. 11. World Scientific Publishing, pp. 2165–2212,
2021.
ista: Abbatiello A, Bulíček M, Maringová E. 2021. On the dynamic slip boundary condition
for Navier-Stokes-like problems. Mathematical Models and Methods in Applied Sciences.
31(11), 2165–2212.
mla: Abbatiello, Anna, et al. “On the Dynamic Slip Boundary Condition for Navier-Stokes-like
Problems.” Mathematical Models and Methods in Applied Sciences, vol. 31,
no. 11, World Scientific Publishing, 2021, pp. 2165–212, doi:10.1142/S0218202521500470.
short: A. Abbatiello, M. Bulíček, E. Maringová, Mathematical Models and Methods
in Applied Sciences 31 (2021) 2165–2212.
date_created: 2021-12-26T23:01:27Z
date_published: 2021-10-13T00:00:00Z
date_updated: 2023-08-17T06:29:01Z
day: '13'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1142/S0218202521500470
external_id:
arxiv:
- '2009.09057'
isi:
- '000722309400001'
file:
- access_level: open_access
checksum: 8c0a9396335f0b70e1f5cbfe450a987a
content_type: application/pdf
creator: dernst
date_created: 2022-05-16T10:55:45Z
date_updated: 2022-05-16T10:55:45Z
file_id: '11385'
file_name: 2021_MathModelsMethods_Abbatiello.pdf
file_size: 795483
relation: main_file
success: 1
file_date_updated: 2022-05-16T10:55:45Z
has_accepted_license: '1'
intvolume: ' 31'
isi: 1
issue: '11'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 2165-2212
project:
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
grant_number: F6504
name: Taming Complexity in Partial Differential Systems
- _id: 260788DE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
name: Dissipation and Dispersion in Nonlinear Partial Differential Equations
publication: Mathematical Models and Methods in Applied Sciences
publication_identifier:
eissn:
- 1793-6314
issn:
- 0218-2025
publication_status: published
publisher: World Scientific Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the dynamic slip boundary condition for Navier-Stokes-like problems
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 31
year: '2021'
...
---
_id: '10574'
abstract:
- lang: eng
text: 'The understanding of material appearance perception is a complex problem
due to interactions between material reflectance, surface geometry, and illumination.
Recently, Serrano et al. collected the largest dataset to date with subjective
ratings of material appearance attributes, including glossiness, metallicness,
sharpness and contrast of reflections. In this work, we make use of their dataset
to investigate for the first time the impact of the interactions between illumination,
geometry, and eight different material categories in perceived appearance attributes.
After an initial analysis, we select for further analysis the four material categories
that cover the largest range for all perceptual attributes: fabric, plastic, ceramic,
and metal. Using a cumulative link mixed model (CLMM) for robust regression, we
discover interactions between these material categories and four representative
illuminations and object geometries. We believe that our findings contribute to
expanding the knowledge on material appearance perception and can be useful for
many applications, such as scene design, where any particular material in a given
shape can be aligned with dominant classes of illumination, so that a desired
strength of appearance attributes can be achieved.'
acknowledgement: This project has received funding from the European Union’s Horizon
2020 research and innovation programme under the Marie Sklodowska-Curie, grant agreement
N∘ 765911 (RealVision) and from the European Research Council (ERC), grant agreement
N∘ 804226 (PERDY). Open Access funding enabled and organized by Projekt DEAL.
article_processing_charge: Yes
article_type: original
author:
- first_name: Bin
full_name: Chen, Bin
last_name: Chen
- first_name: Chao
full_name: Wang, Chao
last_name: Wang
- first_name: Michael
full_name: Piovarci, Michael
id: 62E473F4-5C99-11EA-A40E-AF823DDC885E
last_name: Piovarci
orcid: 0000-0002-5062-4474
- first_name: Hans Peter
full_name: Seidel, Hans Peter
last_name: Seidel
- first_name: Piotr
full_name: Didyk, Piotr
last_name: Didyk
- first_name: Karol
full_name: Myszkowski, Karol
last_name: Myszkowski
- first_name: Ana
full_name: Serrano, Ana
last_name: Serrano
citation:
ama: Chen B, Wang C, Piovarci M, et al. The effect of geometry and illumination
on appearance perception of different material categories. Visual Computer.
2021;37(12):2975-2987. doi:10.1007/s00371-021-02227-x
apa: Chen, B., Wang, C., Piovarci, M., Seidel, H. P., Didyk, P., Myszkowski, K.,
& Serrano, A. (2021). The effect of geometry and illumination on appearance
perception of different material categories. Visual Computer. Springer
Nature. https://doi.org/10.1007/s00371-021-02227-x
chicago: Chen, Bin, Chao Wang, Michael Piovarci, Hans Peter Seidel, Piotr Didyk,
Karol Myszkowski, and Ana Serrano. “The Effect of Geometry and Illumination on
Appearance Perception of Different Material Categories.” Visual Computer.
Springer Nature, 2021. https://doi.org/10.1007/s00371-021-02227-x.
ieee: B. Chen et al., “The effect of geometry and illumination on appearance
perception of different material categories,” Visual Computer, vol. 37,
no. 12. Springer Nature, pp. 2975–2987, 2021.
ista: Chen B, Wang C, Piovarci M, Seidel HP, Didyk P, Myszkowski K, Serrano A. 2021.
The effect of geometry and illumination on appearance perception of different
material categories. Visual Computer. 37(12), 2975–2987.
mla: Chen, Bin, et al. “The Effect of Geometry and Illumination on Appearance Perception
of Different Material Categories.” Visual Computer, vol. 37, no. 12, Springer
Nature, 2021, pp. 2975–87, doi:10.1007/s00371-021-02227-x.
short: B. Chen, C. Wang, M. Piovarci, H.P. Seidel, P. Didyk, K. Myszkowski, A. Serrano,
Visual Computer 37 (2021) 2975–2987.
date_created: 2021-12-26T23:01:26Z
date_published: 2021-12-01T00:00:00Z
date_updated: 2023-08-17T06:29:34Z
day: '01'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1007/s00371-021-02227-x
external_id:
isi:
- '000673536600003'
file:
- access_level: open_access
checksum: 244cfcac0479ca6e3444c098ab2860a1
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-27T13:51:08Z
date_updated: 2021-12-27T13:51:08Z
file_id: '10578'
file_name: 2021_VisComput_Chen.pdf
file_size: 5741094
relation: main_file
success: 1
file_date_updated: 2021-12-27T13:51:08Z
has_accepted_license: '1'
intvolume: ' 37'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 2975-2987
publication: Visual Computer
publication_identifier:
eissn:
- 1432-2315
issn:
- 0178-2789
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effect of geometry and illumination on appearance perception of different
material categories
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 37
year: '2021'
...
---
_id: '10573'
abstract:
- lang: eng
text: How tissues acquire complex shapes is a fundamental question in biology and
regenerative medicine. Zebrafish semicircular canals form from invaginations in
the otic epithelium (buds) that extend and fuse to form the hubs of each canal.
We find that conventional actomyosin-driven behaviors are not required. Instead,
local secretion of hyaluronan, made by the enzymes uridine 5′-diphosphate dehydrogenase
(ugdh) and hyaluronan synthase 3 (has3), drives canal morphogenesis. Charged hyaluronate
polymers osmotically swell with water and generate isotropic extracellular pressure
to deform the overlying epithelium into buds. The mechanical anisotropy needed
to shape buds into tubes is conferred by a polarized distribution of actomyosin
and E-cadherin-rich membrane tethers, which we term cytocinches. Most work on
tissue morphogenesis ascribes actomyosin contractility as the driving force, while
the extracellular matrix shapes tissues through differential stiffness. Our work
inverts this expectation. Hyaluronate pressure shaped by anisotropic tissue stiffness
may be a widespread mechanism for powering morphological change in organogenesis
and tissue engineering.
acknowledgement: We thank Ian Swinburne, Sandy Nandagopal, and Toru Kawanishi for
support, discussions, and reagents. We thank Vanessa Barone, Joseph Nasser, and
members of the Megason lab for useful comments on the manuscript and general feedback.
We are grateful to the Heisenberg and Knaut labs for transgenic fish. Diagrams on
the right in the graphical abstract were created using BioRender. This work was
supported by NIH R01DC015478 and NIH R01GM107733 to S.G.M. A.M. was supported by
Human Frontiers Science Program LTF and NIH K99HD098918.
article_processing_charge: No
article_type: original
author:
- first_name: Akankshi
full_name: Munjal, Akankshi
last_name: Munjal
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Tony Y.C.
full_name: Tsai, Tony Y.C.
last_name: Tsai
- first_name: Timothy J.
full_name: Mitchison, Timothy J.
last_name: Mitchison
- first_name: Sean G.
full_name: Megason, Sean G.
last_name: Megason
citation:
ama: Munjal A, Hannezo EB, Tsai TYC, Mitchison TJ, Megason SG. Extracellular hyaluronate
pressure shaped by cellular tethers drives tissue morphogenesis. Cell.
2021;184(26):6313-6325.e18. doi:10.1016/j.cell.2021.11.025
apa: Munjal, A., Hannezo, E. B., Tsai, T. Y. C., Mitchison, T. J., & Megason,
S. G. (2021). Extracellular hyaluronate pressure shaped by cellular tethers drives
tissue morphogenesis. Cell. Elsevier ; Cell Press. https://doi.org/10.1016/j.cell.2021.11.025
chicago: Munjal, Akankshi, Edouard B Hannezo, Tony Y.C. Tsai, Timothy J. Mitchison,
and Sean G. Megason. “Extracellular Hyaluronate Pressure Shaped by Cellular Tethers
Drives Tissue Morphogenesis.” Cell. Elsevier ; Cell Press, 2021. https://doi.org/10.1016/j.cell.2021.11.025.
ieee: A. Munjal, E. B. Hannezo, T. Y. C. Tsai, T. J. Mitchison, and S. G. Megason,
“Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis,”
Cell, vol. 184, no. 26. Elsevier ; Cell Press, p. 6313–6325.e18, 2021.
ista: Munjal A, Hannezo EB, Tsai TYC, Mitchison TJ, Megason SG. 2021. Extracellular
hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Cell.
184(26), 6313–6325.e18.
mla: Munjal, Akankshi, et al. “Extracellular Hyaluronate Pressure Shaped by Cellular
Tethers Drives Tissue Morphogenesis.” Cell, vol. 184, no. 26, Elsevier ;
Cell Press, 2021, p. 6313–6325.e18, doi:10.1016/j.cell.2021.11.025.
short: A. Munjal, E.B. Hannezo, T.Y.C. Tsai, T.J. Mitchison, S.G. Megason, Cell
184 (2021) 6313–6325.e18.
date_created: 2021-12-26T23:01:26Z
date_published: 2021-12-22T00:00:00Z
date_updated: 2023-08-17T06:28:25Z
day: '22'
department:
- _id: EdHa
doi: 10.1016/j.cell.2021.11.025
external_id:
isi:
- '000735387500002'
intvolume: ' 184'
isi: 1
issue: '26'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.09.28.316042
month: '12'
oa: 1
oa_version: Preprint
page: 6313-6325.e18
publication: Cell
publication_identifier:
eissn:
- 1097-4172
issn:
- 0092-8674
publication_status: published
publisher: Elsevier ; Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extracellular hyaluronate pressure shaped by cellular tethers drives tissue
morphogenesis
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 184
year: '2021'
...
---
_id: '10674'
abstract:
- lang: eng
text: 'In two-player games on graphs, the players move a token through a graph to
produce an infinite path, which determines the winner of the game. Such games
are central in formal methods since they model the interaction between a non-terminating
system and its environment. In bidding games the players bid for the right to
move the token: in each round, the players simultaneously submit bids, and the
higher bidder moves the token and pays the other player. Bidding games are known
to have a clean and elegant mathematical structure that relies on the ability
of the players to submit arbitrarily small bids. Many applications, however, require
a fixed granularity for the bids, which can represent, for example, the monetary
value expressed in cents. We study, for the first time, the combination of discrete-bidding
and infinite-duration games. Our most important result proves that these games
form a large determined subclass of concurrent games, where determinacy is the
strong property that there always exists exactly one player who can guarantee
winning the game. In particular, we show that, in contrast to non-discrete bidding
games, the mechanism with which tied bids are resolved plays an important role
in discrete-bidding games. We study several natural tie-breaking mechanisms and
show that, while some do not admit determinacy, most natural mechanisms imply
determinacy for every pair of initial budgets.'
acknowledgement: "This research was supported in part by the Austrian Science Fund
(FWF) under grants S11402-N23 (RiSE/SHiNE), Z211-N23 (Wittgenstein Award), and M
2369-N33 (Meitner fellowship).\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Milad
full_name: Aghajohari, Milad
last_name: Aghajohari
- first_name: Guy
full_name: Avni, Guy
id: 463C8BC2-F248-11E8-B48F-1D18A9856A87
last_name: Avni
orcid: 0000-0001-5588-8287
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
citation:
ama: Aghajohari M, Avni G, Henzinger TA. Determinacy in discrete-bidding infinite-duration
games. Logical Methods in Computer Science. 2021;17(1):10:1-10:23. doi:10.23638/LMCS-17(1:10)2021
apa: Aghajohari, M., Avni, G., & Henzinger, T. A. (2021). Determinacy in discrete-bidding
infinite-duration games. Logical Methods in Computer Science. International
Federation for Computational Logic. https://doi.org/10.23638/LMCS-17(1:10)2021
chicago: Aghajohari, Milad, Guy Avni, and Thomas A Henzinger. “Determinacy in Discrete-Bidding
Infinite-Duration Games.” Logical Methods in Computer Science. International
Federation for Computational Logic, 2021. https://doi.org/10.23638/LMCS-17(1:10)2021.
ieee: M. Aghajohari, G. Avni, and T. A. Henzinger, “Determinacy in discrete-bidding
infinite-duration games,” Logical Methods in Computer Science, vol. 17,
no. 1. International Federation for Computational Logic, p. 10:1-10:23, 2021.
ista: Aghajohari M, Avni G, Henzinger TA. 2021. Determinacy in discrete-bidding
infinite-duration games. Logical Methods in Computer Science. 17(1), 10:1-10:23.
mla: Aghajohari, Milad, et al. “Determinacy in Discrete-Bidding Infinite-Duration
Games.” Logical Methods in Computer Science, vol. 17, no. 1, International
Federation for Computational Logic, 2021, p. 10:1-10:23, doi:10.23638/LMCS-17(1:10)2021.
short: M. Aghajohari, G. Avni, T.A. Henzinger, Logical Methods in Computer Science
17 (2021) 10:1-10:23.
date_created: 2022-01-25T16:32:13Z
date_published: 2021-02-03T00:00:00Z
date_updated: 2023-08-17T06:56:42Z
day: '03'
ddc:
- '510'
department:
- _id: ToHe
doi: 10.23638/LMCS-17(1:10)2021
external_id:
arxiv:
- '1905.03588'
isi:
- '000658724600010'
file:
- access_level: open_access
checksum: b35586a50ed1ca8f44767de116d18d81
content_type: application/pdf
creator: alisjak
date_created: 2022-01-26T08:04:50Z
date_updated: 2022-01-26T08:04:50Z
file_id: '10690'
file_name: 2021_LMCS_AGHAJOHAR.pdf
file_size: 819878
relation: main_file
success: 1
file_date_updated: 2022-01-26T08:04:50Z
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
issue: '1'
keyword:
- computer science
- computer science and game theory
- logic in computer science
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 10:1-10:23
project:
- _id: 264B3912-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02369
name: Formal Methods meets Algorithmic Game Theory
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: Logical Methods in Computer Science
publication_identifier:
eissn:
- 1860-5974
publication_status: published
publisher: International Federation for Computational Logic
quality_controlled: '1'
scopus_import: '1'
status: public
title: Determinacy in discrete-bidding infinite-duration games
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2021'
...
---
_id: '10609'
abstract:
- lang: eng
text: "We study Multi-party computation (MPC) in the setting of subversion, where
the adversary tampers with the machines of honest parties. Our goal is to construct
actively secure MPC protocols where parties are corrupted adaptively by an adversary
(as in the standard adaptive security setting), and in addition, honest parties’
machines are compromised.\r\nThe idea of reverse firewalls (RF) was introduced
at EUROCRYPT’15 by Mironov and Stephens-Davidowitz as an approach to protecting
protocols against corruption of honest parties’ devices. Intuitively, an RF for
a party P is an external entity that sits between P and the outside world
and whose scope is to sanitize P ’s incoming and outgoing messages in the face
of subversion of their computer. Mironov and Stephens-Davidowitz constructed a
protocol for passively-secure two-party computation. At CRYPTO’20, Chakraborty,
Dziembowski and Nielsen constructed a protocol for secure computation with firewalls
that improved on this result, both by extending it to multi-party computation
protocol, and considering active security in the presence of static corruptions.
In this paper, we initiate the study of RF for MPC in the adaptive setting. We
put forward a definition for adaptively secure MPC in the reverse firewall setting,
explore relationships among the security notions, and then construct reverse firewalls
for MPC in this stronger setting of adaptive security. We also resolve the open
question of Chakraborty, Dziembowski and Nielsen by removing the need for a trusted
setup in constructing RF for MPC. Towards this end, we construct reverse firewalls
for adaptively secure augmented coin tossing and adaptively secure zero-knowledge
protocols and obtain a constant round adaptively secure MPC protocol in the reverse
firewall setting without setup. Along the way, we propose a new multi-party adaptively
secure coin tossing protocol in the plain model, that is of independent interest."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Suvradip
full_name: Chakraborty, Suvradip
id: B9CD0494-D033-11E9-B219-A439E6697425
last_name: Chakraborty
- first_name: Chaya
full_name: Ganesh, Chaya
last_name: Ganesh
- first_name: Mahak
full_name: Pancholi, Mahak
last_name: Pancholi
- first_name: Pratik
full_name: Sarkar, Pratik
last_name: Sarkar
citation:
ama: 'Chakraborty S, Ganesh C, Pancholi M, Sarkar P. Reverse firewalls for adaptively
secure MPC without setup. In: 27th International Conference on the Theory and
Application of Cryptology and Information Security. Vol 13091. Springer Nature;
2021:335-364. doi:10.1007/978-3-030-92075-3_12'
apa: 'Chakraborty, S., Ganesh, C., Pancholi, M., & Sarkar, P. (2021). Reverse
firewalls for adaptively secure MPC without setup. In 27th International Conference
on the Theory and Application of Cryptology and Information Security (Vol.
13091, pp. 335–364). Virtual, Singapore: Springer Nature. https://doi.org/10.1007/978-3-030-92075-3_12'
chicago: Chakraborty, Suvradip, Chaya Ganesh, Mahak Pancholi, and Pratik Sarkar.
“Reverse Firewalls for Adaptively Secure MPC without Setup.” In 27th International
Conference on the Theory and Application of Cryptology and Information Security,
13091:335–64. Springer Nature, 2021. https://doi.org/10.1007/978-3-030-92075-3_12.
ieee: S. Chakraborty, C. Ganesh, M. Pancholi, and P. Sarkar, “Reverse firewalls
for adaptively secure MPC without setup,” in 27th International Conference
on the Theory and Application of Cryptology and Information Security, Virtual,
Singapore, 2021, vol. 13091, pp. 335–364.
ista: 'Chakraborty S, Ganesh C, Pancholi M, Sarkar P. 2021. Reverse firewalls for
adaptively secure MPC without setup. 27th International Conference on the Theory
and Application of Cryptology and Information Security. ASIACRYPT: International
Conference on Cryptology in Asia, LNCS, vol. 13091, 335–364.'
mla: Chakraborty, Suvradip, et al. “Reverse Firewalls for Adaptively Secure MPC
without Setup.” 27th International Conference on the Theory and Application
of Cryptology and Information Security, vol. 13091, Springer Nature, 2021,
pp. 335–64, doi:10.1007/978-3-030-92075-3_12.
short: S. Chakraborty, C. Ganesh, M. Pancholi, P. Sarkar, in:, 27th International
Conference on the Theory and Application of Cryptology and Information Security,
Springer Nature, 2021, pp. 335–364.
conference:
end_date: 2021-12-10
location: Virtual, Singapore
name: 'ASIACRYPT: International Conference on Cryptology in Asia'
start_date: 2021-12-06
date_created: 2022-01-09T23:01:27Z
date_published: 2021-12-01T00:00:00Z
date_updated: 2023-08-17T06:34:41Z
day: '01'
department:
- _id: KrPi
doi: 10.1007/978-3-030-92075-3_12
ec_funded: 1
external_id:
isi:
- '000927876200012'
intvolume: ' 13091'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2021/1262
month: '12'
oa: 1
oa_version: Preprint
page: 335-364
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
publication: 27th International Conference on the Theory and Application of Cryptology
and Information Security
publication_identifier:
eisbn:
- 978-3-030-92075-3
eissn:
- 1611-3349
isbn:
- 978-3-030-92074-6
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reverse firewalls for adaptively secure MPC without setup
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13091
year: '2021'
...
---
_id: '10606'
abstract:
- lang: eng
text: Cell division orientation is thought to result from a competition between
cell geometry and polarity domains controlling the position of the mitotic spindle
during mitosis. Depending on the level of cell shape anisotropy or the strength
of the polarity domain, one dominates the other and determines the orientation
of the spindle. Whether and how such competition is also at work to determine
unequal cell division (UCD), producing daughter cells of different size, remains
unclear. Here, we show that cell geometry and polarity domains cooperate, rather
than compete, in positioning the cleavage plane during UCDs in early ascidian
embryos. We found that the UCDs and their orientation at the ascidian third cleavage
rely on the spindle tilting in an anisotropic cell shape, and cortical polarity
domains exerting different effects on spindle astral microtubules. By systematically
varying mitotic cell shape, we could modulate the effect of attractive and repulsive
polarity domains and consequently generate predicted daughter cell size asymmetries
and position. We therefore propose that the spindle position during UCD is set
by the combined activities of cell geometry and polarity domains, where cell geometry
modulates the effect of cortical polarity domain(s).
acknowledged_ssus:
- _id: NanoFab
- _id: Bio
acknowledgement: 'We thank members of the Heisenberg and McDougall groups for technical
advice and discussion. We are grateful to the Bioimaging and Nanofabrication facilities
of IST Austria and the Imaging Platform (PIM) and animal facility (CRB) of Institut
de la Mer de Villefranche (IMEV), which is supported by EMBRC-France, whose French
state funds are managed by the ANR within the Investments of the Future program
under reference ANR-10-INBS-0, for continuous support. This work was supported by
a collaborative grant from the French Government funding agency Agence National
de la Recherche to McDougall (ANR ''MorCell'': ANR-17-CE 13-0028) and the Austrian
Science Fund to Heisenberg (FWF: I 3601-B27).'
article_number: e75639
article_processing_charge: No
article_type: original
author:
- first_name: Benoit G
full_name: Godard, Benoit G
id: 33280250-F248-11E8-B48F-1D18A9856A87
last_name: Godard
- first_name: Remi
full_name: Dumollard, Remi
last_name: Dumollard
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Alex
full_name: Mcdougall, Alex
last_name: Mcdougall
citation:
ama: Godard BG, Dumollard R, Heisenberg C-PJ, Mcdougall A. Combined effect of cell
geometry and polarity domains determines the orientation of unequal division.
eLife. 2021;10. doi:10.7554/eLife.75639
apa: Godard, B. G., Dumollard, R., Heisenberg, C.-P. J., & Mcdougall, A. (2021).
Combined effect of cell geometry and polarity domains determines the orientation
of unequal division. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.75639
chicago: Godard, Benoit G, Remi Dumollard, Carl-Philipp J Heisenberg, and Alex Mcdougall.
“Combined Effect of Cell Geometry and Polarity Domains Determines the Orientation
of Unequal Division.” ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/eLife.75639.
ieee: B. G. Godard, R. Dumollard, C.-P. J. Heisenberg, and A. Mcdougall, “Combined
effect of cell geometry and polarity domains determines the orientation of unequal
division,” eLife, vol. 10. eLife Sciences Publications, 2021.
ista: Godard BG, Dumollard R, Heisenberg C-PJ, Mcdougall A. 2021. Combined effect
of cell geometry and polarity domains determines the orientation of unequal division.
eLife. 10, e75639.
mla: Godard, Benoit G., et al. “Combined Effect of Cell Geometry and Polarity Domains
Determines the Orientation of Unequal Division.” ELife, vol. 10, e75639,
eLife Sciences Publications, 2021, doi:10.7554/eLife.75639.
short: B.G. Godard, R. Dumollard, C.-P.J. Heisenberg, A. Mcdougall, ELife 10 (2021).
date_created: 2022-01-09T23:01:26Z
date_published: 2021-12-21T00:00:00Z
date_updated: 2023-08-17T06:32:44Z
day: '21'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.7554/eLife.75639
external_id:
isi:
- '000733610100001'
file:
- access_level: open_access
checksum: 759c7a873d554c48a6639e6350746ca6
content_type: application/pdf
creator: alisjak
date_created: 2022-01-10T09:40:37Z
date_updated: 2022-01-10T09:40:37Z
file_id: '10611'
file_name: 2021_eLife_Godard.pdf
file_size: 7769934
relation: main_file
success: 1
file_date_updated: 2022-01-10T09:40:37Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 2646861A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03601
name: Control of embryonic cleavage pattern
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combined effect of cell geometry and polarity domains determines the orientation
of unequal division
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '10607'
abstract:
- lang: eng
text: The evidence linking innate immunity mechanisms and neurodegenerative diseases
is growing, but the specific mechanisms are incompletely understood. Experimental
data suggest that microglial TLR4 mediates the uptake and clearance of α-synuclein
also termed synucleinophagy. The accumulation of misfolded α-synuclein throughout
the brain is central to Parkinson's disease (PD). The distribution and progression
of the pathology is often attributed to the propagation of α-synuclein. Here,
we apply a classical α-synuclein propagation model of prodromal PD in wild type
and TLR4 deficient mice to study the role of TLR4 in the progression of the disease.
Our data suggest that TLR4 deficiency facilitates the α-synuclein seed spreading
associated with reduced lysosomal activity of microglia. Three months after seed
inoculation, more pronounced proteinase K-resistant α-synuclein inclusion pathology
is observed in mice with TLR4 deficiency. The facilitated propagation of α-synuclein
is associated with early loss of dopamine transporter (DAT) signal in the striatum
and loss of dopaminergic neurons in substantia nigra pars compacta of TLR4 deficient
mice. These new results support TLR4 signaling as a putative target for disease
modification to slow the progression of PD and related disorders.
acknowledgement: This study was supported by grants of the Austrian Science Fund (FWF)
F4414 and W1206-08. Electron microscopy was performed at the Scientific Service
Units (SSU) of IST-Austria through resources provided by the Electron Microscopy
Facility.
article_processing_charge: No
article_type: original
author:
- first_name: Serena
full_name: Venezia, Serena
last_name: Venezia
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Gregor K.
full_name: Wenning, Gregor K.
last_name: Wenning
- first_name: Nadia
full_name: Stefanova, Nadia
last_name: Stefanova
citation:
ama: Venezia S, Kaufmann W, Wenning GK, Stefanova N. Toll-like receptor 4 deficiency
facilitates α-synuclein propagation and neurodegeneration in a mouse model of
prodromal Parkinson’s disease. Parkinsonism & Related Disorders. 2021;91:59-65.
doi:10.1016/j.parkreldis.2021.09.007
apa: Venezia, S., Kaufmann, W., Wenning, G. K., & Stefanova, N. (2021). Toll-like
receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration
in a mouse model of prodromal Parkinson’s disease. Parkinsonism & Related
Disorders. Elsevier. https://doi.org/10.1016/j.parkreldis.2021.09.007
chicago: Venezia, Serena, Walter Kaufmann, Gregor K. Wenning, and Nadia Stefanova.
“Toll-like Receptor 4 Deficiency Facilitates α-Synuclein Propagation and Neurodegeneration
in a Mouse Model of Prodromal Parkinson’s Disease.” Parkinsonism & Related
Disorders. Elsevier, 2021. https://doi.org/10.1016/j.parkreldis.2021.09.007.
ieee: S. Venezia, W. Kaufmann, G. K. Wenning, and N. Stefanova, “Toll-like receptor
4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse
model of prodromal Parkinson’s disease,” Parkinsonism & Related Disorders,
vol. 91. Elsevier, pp. 59–65, 2021.
ista: Venezia S, Kaufmann W, Wenning GK, Stefanova N. 2021. Toll-like receptor 4
deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse
model of prodromal Parkinson’s disease. Parkinsonism & Related Disorders.
91, 59–65.
mla: Venezia, Serena, et al. “Toll-like Receptor 4 Deficiency Facilitates α-Synuclein
Propagation and Neurodegeneration in a Mouse Model of Prodromal Parkinson’s Disease.”
Parkinsonism & Related Disorders, vol. 91, Elsevier, 2021, pp. 59–65,
doi:10.1016/j.parkreldis.2021.09.007.
short: S. Venezia, W. Kaufmann, G.K. Wenning, N. Stefanova, Parkinsonism & Related
Disorders 91 (2021) 59–65.
date_created: 2022-01-09T23:01:26Z
date_published: 2021-10-01T00:00:00Z
date_updated: 2023-08-17T06:36:01Z
day: '01'
ddc:
- '610'
department:
- _id: EM-Fac
doi: 10.1016/j.parkreldis.2021.09.007
external_id:
isi:
- '000701142900012'
pmid:
- '34530328'
file:
- access_level: open_access
checksum: 360681585acb51e80d17c6b213c56b55
content_type: application/pdf
creator: alisjak
date_created: 2022-01-10T13:41:40Z
date_updated: 2022-01-10T13:41:40Z
file_id: '10612'
file_name: 2021_Parkinsonism_Venezia.pdf
file_size: 6848513
relation: main_file
success: 1
file_date_updated: 2022-01-10T13:41:40Z
has_accepted_license: '1'
intvolume: ' 91'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 59-65
pmid: 1
publication: Parkinsonism & Related Disorders
publication_identifier:
eissn:
- 1873-5126
issn:
- 1353-8020
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration
in a mouse model of prodromal Parkinson's disease
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 91
year: '2021'
...
---
_id: '10628'
abstract:
- lang: eng
text: The surface states of 3D topological insulators in general have negligible
quantum oscillations (QOs) when the chemical potential is tuned to the Dirac points.
In contrast, we find that topological Kondo insulators (TKIs) can support surface
states with an arbitrarily large Fermi surface (FS) when the chemical potential
is pinned to the Dirac point. We illustrate that these FSs give rise to finite-frequency
QOs, which can become comparable to the extremal area of the unhybridized bulk
bands. We show that this occurs when the crystal symmetry is lowered from cubic
to tetragonal in a minimal two-orbital model. We label such surface modes as 'shadow
surface states'. Moreover, we show that the sufficient next-nearest neighbor out-of-plane
hybridization leading to shadow surface states can be self-consistently stabilized
for tetragonal TKIs. Consequently, shadow surface states provide an important
example of high-frequency QOs beyond the context of cubic TKIs.
acknowledgement: PG acknowledges support from National Science Foundation Awards No.
DMR-1824265 for this work. AG acknowledges support from the European Union's Horizon
2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement
No. 754411. EMN is supported by ASU startup grant. OE is in part supported by NSF-DMR-1904716.
article_number: '123042'
article_processing_charge: No
article_type: original
author:
- first_name: Areg
full_name: Ghazaryan, Areg
id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
last_name: Ghazaryan
orcid: 0000-0001-9666-3543
- first_name: Emilian M.
full_name: Nica, Emilian M.
last_name: Nica
- first_name: Onur
full_name: Erten, Onur
last_name: Erten
- first_name: Pouyan
full_name: Ghaemi, Pouyan
last_name: Ghaemi
citation:
ama: Ghazaryan A, Nica EM, Erten O, Ghaemi P. Shadow surface states in topological
Kondo insulators. New Journal of Physics. 2021;23(12). doi:10.1088/1367-2630/ac4124
apa: Ghazaryan, A., Nica, E. M., Erten, O., & Ghaemi, P. (2021). Shadow surface
states in topological Kondo insulators. New Journal of Physics. IOP Publishing.
https://doi.org/10.1088/1367-2630/ac4124
chicago: Ghazaryan, Areg, Emilian M. Nica, Onur Erten, and Pouyan Ghaemi. “Shadow
Surface States in Topological Kondo Insulators.” New Journal of Physics.
IOP Publishing, 2021. https://doi.org/10.1088/1367-2630/ac4124.
ieee: A. Ghazaryan, E. M. Nica, O. Erten, and P. Ghaemi, “Shadow surface states
in topological Kondo insulators,” New Journal of Physics, vol. 23, no.
12. IOP Publishing, 2021.
ista: Ghazaryan A, Nica EM, Erten O, Ghaemi P. 2021. Shadow surface states in topological
Kondo insulators. New Journal of Physics. 23(12), 123042.
mla: Ghazaryan, Areg, et al. “Shadow Surface States in Topological Kondo Insulators.”
New Journal of Physics, vol. 23, no. 12, 123042, IOP Publishing, 2021,
doi:10.1088/1367-2630/ac4124.
short: A. Ghazaryan, E.M. Nica, O. Erten, P. Ghaemi, New Journal of Physics 23 (2021).
date_created: 2022-01-16T23:01:28Z
date_published: 2021-12-23T00:00:00Z
date_updated: 2023-08-17T06:54:54Z
day: '23'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1088/1367-2630/ac4124
ec_funded: 1
external_id:
arxiv:
- '2012.11625'
isi:
- '000734063700001'
file:
- access_level: open_access
checksum: 0c3cb6816242fa8afd1cc87a5fe77821
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-17T10:01:58Z
date_updated: 2022-01-17T10:01:58Z
file_id: '10632'
file_name: 2021_NewJourPhys_Ghazaryan.pdf
file_size: 2533102
relation: main_file
success: 1
file_date_updated: 2022-01-17T10:01:58Z
has_accepted_license: '1'
intvolume: ' 23'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: New Journal of Physics
publication_identifier:
issn:
- 1367-2630
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Shadow surface states in topological Kondo insulators
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 23
year: '2021'
...
---
_id: '10631'
abstract:
- lang: eng
text: We combine experimental and theoretical approaches to explore excited rotational
states of molecules embedded in helium nanodroplets using CS2 and I2 as examples.
Laser-induced nonadiabatic molecular alignment is employed to measure spectral
lines for rotational states extending beyond those initially populated at the
0.37 K droplet temperature. We construct a simple quantum-mechanical model, based
on a linear rotor coupled to a single-mode bosonic bath, to determine the rotational
energy structure in its entirety. The calculated and measured spectral lines are
in good agreement. We show that the effect of the surrounding superfluid on molecular
rotation can be rationalized by a single quantity, the angular momentum, transferred
from the molecule to the droplet.
acknowledgement: I.C. acknowledges the support by the European Union’s Horizon 2020
research and innovation programme under the Marie Sklodowska-Curie Grant Agreement
No. 665385. G.B. acknowledges support from the Austrian Science Fund (FWF), under
project No. M2461-N27. M.L. acknowledges support by the Austrian Science Fund (FWF),
under project No. P29902-N27, and by the European Research Council (ERC) Starting
Grant No. 801770 (ANGULON). H.S acknowledges support from the European Research
Council-AdG (Project No. 320459, DropletControl) and from The Villum Foundation
through a Villum Investigator grant no. 25886.
article_number: L061303
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Cherepanov, Igor
id: 339C7E5A-F248-11E8-B48F-1D18A9856A87
last_name: Cherepanov
- first_name: Giacomo
full_name: Bighin, Giacomo
id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
last_name: Bighin
orcid: 0000-0001-8823-9777
- first_name: Constant A.
full_name: Schouder, Constant A.
last_name: Schouder
- first_name: Adam S.
full_name: Chatterley, Adam S.
last_name: Chatterley
- first_name: Simon H.
full_name: Albrechtsen, Simon H.
last_name: Albrechtsen
- first_name: Alberto Viñas
full_name: Muñoz, Alberto Viñas
last_name: Muñoz
- first_name: Lars
full_name: Christiansen, Lars
last_name: Christiansen
- first_name: Henrik
full_name: Stapelfeldt, Henrik
last_name: Stapelfeldt
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
citation:
ama: Cherepanov I, Bighin G, Schouder CA, et al. Excited rotational states of molecules
in a superfluid. Physical Review A. 2021;104(6). doi:10.1103/PhysRevA.104.L061303
apa: Cherepanov, I., Bighin, G., Schouder, C. A., Chatterley, A. S., Albrechtsen,
S. H., Muñoz, A. V., … Lemeshko, M. (2021). Excited rotational states of molecules
in a superfluid. Physical Review A. American Physical Society. https://doi.org/10.1103/PhysRevA.104.L061303
chicago: Cherepanov, Igor, Giacomo Bighin, Constant A. Schouder, Adam S. Chatterley,
Simon H. Albrechtsen, Alberto Viñas Muñoz, Lars Christiansen, Henrik Stapelfeldt,
and Mikhail Lemeshko. “Excited Rotational States of Molecules in a Superfluid.”
Physical Review A. American Physical Society, 2021. https://doi.org/10.1103/PhysRevA.104.L061303.
ieee: I. Cherepanov et al., “Excited rotational states of molecules in a
superfluid,” Physical Review A, vol. 104, no. 6. American Physical Society,
2021.
ista: Cherepanov I, Bighin G, Schouder CA, Chatterley AS, Albrechtsen SH, Muñoz
AV, Christiansen L, Stapelfeldt H, Lemeshko M. 2021. Excited rotational states
of molecules in a superfluid. Physical Review A. 104(6), L061303.
mla: Cherepanov, Igor, et al. “Excited Rotational States of Molecules in a Superfluid.”
Physical Review A, vol. 104, no. 6, L061303, American Physical Society,
2021, doi:10.1103/PhysRevA.104.L061303.
short: I. Cherepanov, G. Bighin, C.A. Schouder, A.S. Chatterley, S.H. Albrechtsen,
A.V. Muñoz, L. Christiansen, H. Stapelfeldt, M. Lemeshko, Physical Review A 104
(2021).
date_created: 2022-01-16T23:01:29Z
date_published: 2021-12-30T00:00:00Z
date_updated: 2023-08-17T06:52:17Z
day: '30'
department:
- _id: MiLe
doi: 10.1103/PhysRevA.104.L061303
ec_funded: 1
external_id:
arxiv:
- '2107.00468'
isi:
- '000739618300001'
intvolume: ' 104'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://128.84.4.18/abs/2107.00468
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 26031614-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29902
name: Quantum rotations in the presence of a many-body environment
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '801770'
name: 'Angulon: physics and applications of a new quasiparticle'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 26986C82-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02641
name: A path-integral approach to composite impurities
publication: Physical Review A
publication_identifier:
eissn:
- 2469-9934
issn:
- 2469-9926
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Excited rotational states of molecules in a superfluid
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 104
year: '2021'
...
---
_id: '10597'
abstract:
- lang: eng
text: We thank Emmanuel Abbe and Min Ye for providing us the implementation of RPA
decoding. D. Fathollahi and M. Mondelli are partially supported by the 2019 Lopez-Loreta
Prize. N. Farsad is supported by Discovery Grant from the Natural Sciences and
Engineering Research Council of Canada (NSERC) and Canada Foundation for Innovation
(CFI), John R. Evans Leader Fund. S. A. Hashemi is supported by a Postdoctoral
Fellowship from NSERC.
article_processing_charge: No
author:
- first_name: Dorsa
full_name: Fathollahi, Dorsa
last_name: Fathollahi
- first_name: Nariman
full_name: Farsad, Nariman
last_name: Farsad
- first_name: Seyyed Ali
full_name: Hashemi, Seyyed Ali
last_name: Hashemi
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
citation:
ama: 'Fathollahi D, Farsad N, Hashemi SA, Mondelli M. Sparse multi-decoder recursive
projection aggregation for Reed-Muller codes. In: 2021 IEEE International Symposium
on Information Theory. Institute of Electrical and Electronics Engineers;
2021:1082-1087. doi:10.1109/isit45174.2021.9517887'
apa: 'Fathollahi, D., Farsad, N., Hashemi, S. A., & Mondelli, M. (2021). Sparse
multi-decoder recursive projection aggregation for Reed-Muller codes. In 2021
IEEE International Symposium on Information Theory (pp. 1082–1087). Virtual,
Melbourne, Australia: Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/isit45174.2021.9517887'
chicago: Fathollahi, Dorsa, Nariman Farsad, Seyyed Ali Hashemi, and Marco Mondelli.
“Sparse Multi-Decoder Recursive Projection Aggregation for Reed-Muller Codes.”
In 2021 IEEE International Symposium on Information Theory, 1082–87. Institute
of Electrical and Electronics Engineers, 2021. https://doi.org/10.1109/isit45174.2021.9517887.
ieee: D. Fathollahi, N. Farsad, S. A. Hashemi, and M. Mondelli, “Sparse multi-decoder
recursive projection aggregation for Reed-Muller codes,” in 2021 IEEE International
Symposium on Information Theory, Virtual, Melbourne, Australia, 2021, pp.
1082–1087.
ista: 'Fathollahi D, Farsad N, Hashemi SA, Mondelli M. 2021. Sparse multi-decoder
recursive projection aggregation for Reed-Muller codes. 2021 IEEE International
Symposium on Information Theory. ISIT: International Symposium on Information
Theory, 1082–1087.'
mla: Fathollahi, Dorsa, et al. “Sparse Multi-Decoder Recursive Projection Aggregation
for Reed-Muller Codes.” 2021 IEEE International Symposium on Information Theory,
Institute of Electrical and Electronics Engineers, 2021, pp. 1082–87, doi:10.1109/isit45174.2021.9517887.
short: D. Fathollahi, N. Farsad, S.A. Hashemi, M. Mondelli, in:, 2021 IEEE International
Symposium on Information Theory, Institute of Electrical and Electronics Engineers,
2021, pp. 1082–1087.
conference:
end_date: 2021-07-20
location: Virtual, Melbourne, Australia
name: 'ISIT: International Symposium on Information Theory'
start_date: 2021-07-12
date_created: 2022-01-03T11:31:26Z
date_published: 2021-09-01T00:00:00Z
date_updated: 2023-08-17T06:32:06Z
day: '01'
department:
- _id: MaMo
doi: 10.1109/isit45174.2021.9517887
external_id:
arxiv:
- '2011.12882'
isi:
- '000701502201029'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2011.12882
month: '09'
oa: 1
oa_version: Preprint
page: 1082-1087
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: 2021 IEEE International Symposium on Information Theory
publication_identifier:
eisbn:
- 978-1-5386-8209-8
isbn:
- 978-1-5386-8210-4
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sparse multi-decoder recursive projection aggregation for Reed-Muller codes
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2021'
...
---
_id: '10666'
abstract:
- lang: eng
text: Adversarial training is an effective method to train deep learning models
that are resilient to norm-bounded perturbations, with the cost of nominal performance
drop. While adversarial training appears to enhance the robustness and safety
of a deep model deployed in open-world decision-critical applications, counterintuitively,
it induces undesired behaviors in robot learning settings. In this paper, we show
theoretically and experimentally that neural controllers obtained via adversarial
training are subjected to three types of defects, namely transient, systematic,
and conditional errors. We first generalize adversarial training to a safety-domain
optimization scheme allowing for more generic specifications. We then prove that
such a learning process tends to cause certain error profiles. We support our
theoretical results by a thorough experimental safety analysis in a robot-learning
task. Our results suggest that adversarial training is not yet ready for robot
learning.
acknowledgement: M.L. and T.A.H. are supported in part by the Austrian Science Fund
(FWF) under grant Z211-N23 (Wittgenstein Award). R.H. and D.R. are supported by
Boeing and R.G. by Horizon-2020 ECSEL Project grant no. 783163 (iDev40).
article_processing_charge: No
author:
- first_name: Mathias
full_name: Lechner, Mathias
id: 3DC22916-F248-11E8-B48F-1D18A9856A87
last_name: Lechner
- first_name: Ramin
full_name: Hasani, Ramin
last_name: Hasani
- first_name: Radu
full_name: Grosu, Radu
last_name: Grosu
- first_name: Daniela
full_name: Rus, Daniela
last_name: Rus
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
citation:
ama: 'Lechner M, Hasani R, Grosu R, Rus D, Henzinger TA. Adversarial training is
not ready for robot learning. In: 2021 IEEE International Conference on Robotics
and Automation. ICRA. ; 2021:4140-4147. doi:10.1109/ICRA48506.2021.9561036'
apa: Lechner, M., Hasani, R., Grosu, R., Rus, D., & Henzinger, T. A. (2021).
Adversarial training is not ready for robot learning. In 2021 IEEE International
Conference on Robotics and Automation (pp. 4140–4147). Xi’an, China. https://doi.org/10.1109/ICRA48506.2021.9561036
chicago: Lechner, Mathias, Ramin Hasani, Radu Grosu, Daniela Rus, and Thomas A Henzinger.
“Adversarial Training Is Not Ready for Robot Learning.” In 2021 IEEE International
Conference on Robotics and Automation, 4140–47. ICRA, 2021. https://doi.org/10.1109/ICRA48506.2021.9561036.
ieee: M. Lechner, R. Hasani, R. Grosu, D. Rus, and T. A. Henzinger, “Adversarial
training is not ready for robot learning,” in 2021 IEEE International Conference
on Robotics and Automation, Xi’an, China, 2021, pp. 4140–4147.
ista: 'Lechner M, Hasani R, Grosu R, Rus D, Henzinger TA. 2021. Adversarial training
is not ready for robot learning. 2021 IEEE International Conference on Robotics
and Automation. ICRA: International Conference on Robotics and AutomationICRA,
4140–4147.'
mla: Lechner, Mathias, et al. “Adversarial Training Is Not Ready for Robot Learning.”
2021 IEEE International Conference on Robotics and Automation, 2021, pp.
4140–47, doi:10.1109/ICRA48506.2021.9561036.
short: M. Lechner, R. Hasani, R. Grosu, D. Rus, T.A. Henzinger, in:, 2021 IEEE International
Conference on Robotics and Automation, 2021, pp. 4140–4147.
conference:
end_date: 2021-06-05
location: Xi'an, China
name: 'ICRA: International Conference on Robotics and Automation'
start_date: 2021-05-30
date_created: 2022-01-25T15:44:54Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-08-17T06:58:38Z
ddc:
- '000'
department:
- _id: GradSch
- _id: ToHe
doi: 10.1109/ICRA48506.2021.9561036
external_id:
arxiv:
- '2103.08187'
isi:
- '000765738803040'
has_accepted_license: '1'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/3.0/
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2103.08187
oa: 1
oa_version: None
page: 4140-4147
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: 2021 IEEE International Conference on Robotics and Automation
publication_identifier:
eisbn:
- 978-1-7281-9077-8
eissn:
- 2577-087X
isbn:
- 978-1-7281-9078-5
issn:
- 1050-4729
publication_status: published
quality_controlled: '1'
related_material:
record:
- id: '11362'
relation: dissertation_contains
status: public
series_title: ICRA
status: public
title: Adversarial training is not ready for robot learning
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND
3.0)
short: CC BY-NC-ND (3.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2021'
...
---
_id: '10711'
abstract:
- lang: eng
text: In this paper, we investigate the distribution of the maximum of partial sums
of families of m -periodic complex-valued functions satisfying certain conditions.
We obtain precise uniform estimates for the distribution function of this maximum
in a near-optimal range. Our results apply to partial sums of Kloosterman sums
and other families of ℓ -adic trace functions, and are as strong as those obtained
by Bober, Goldmakher, Granville and Koukoulopoulos for character sums. In particular,
we improve on the recent work of the third author for Birch sums. However, unlike
character sums, we are able to construct families of m -periodic complex-valued
functions which satisfy our conditions, but for which the Pólya–Vinogradov inequality
is sharp.
acknowledgement: We would like to thank the anonymous referees for carefully reading
the paper and for their remarks and suggestions.
article_processing_charge: No
article_type: original
author:
- first_name: Pascal
full_name: Autissier, Pascal
last_name: Autissier
- first_name: Dante
full_name: Bonolis, Dante
id: 6A459894-5FDD-11E9-AF35-BB24E6697425
last_name: Bonolis
- first_name: Youness
full_name: Lamzouri, Youness
last_name: Lamzouri
citation:
ama: Autissier P, Bonolis D, Lamzouri Y. The distribution of the maximum of partial
sums of Kloosterman sums and other trace functions. Compositio Mathematica.
2021;157(7):1610-1651. doi:10.1112/s0010437x21007351
apa: Autissier, P., Bonolis, D., & Lamzouri, Y. (2021). The distribution of
the maximum of partial sums of Kloosterman sums and other trace functions. Compositio
Mathematica. Cambridge University Press. https://doi.org/10.1112/s0010437x21007351
chicago: Autissier, Pascal, Dante Bonolis, and Youness Lamzouri. “The Distribution
of the Maximum of Partial Sums of Kloosterman Sums and Other Trace Functions.”
Compositio Mathematica. Cambridge University Press, 2021. https://doi.org/10.1112/s0010437x21007351.
ieee: P. Autissier, D. Bonolis, and Y. Lamzouri, “The distribution of the maximum
of partial sums of Kloosterman sums and other trace functions,” Compositio
Mathematica, vol. 157, no. 7. Cambridge University Press, pp. 1610–1651, 2021.
ista: Autissier P, Bonolis D, Lamzouri Y. 2021. The distribution of the maximum
of partial sums of Kloosterman sums and other trace functions. Compositio Mathematica.
157(7), 1610–1651.
mla: Autissier, Pascal, et al. “The Distribution of the Maximum of Partial Sums
of Kloosterman Sums and Other Trace Functions.” Compositio Mathematica,
vol. 157, no. 7, Cambridge University Press, 2021, pp. 1610–51, doi:10.1112/s0010437x21007351.
short: P. Autissier, D. Bonolis, Y. Lamzouri, Compositio Mathematica 157 (2021)
1610–1651.
date_created: 2022-02-01T08:10:43Z
date_published: 2021-06-28T00:00:00Z
date_updated: 2023-08-17T06:59:16Z
day: '28'
department:
- _id: TiBr
doi: 10.1112/s0010437x21007351
external_id:
arxiv:
- '1909.03266'
isi:
- '000667289300001'
intvolume: ' 157'
isi: 1
issue: '7'
keyword:
- Algebra and Number Theory
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1909.03266
month: '06'
oa: 1
oa_version: Preprint
page: 1610-1651
publication: Compositio Mathematica
publication_identifier:
eissn:
- 1570-5846
issn:
- 0010-437X
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: The distribution of the maximum of partial sums of Kloosterman sums and other
trace functions
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 157
year: '2021'
...
---
_id: '10809'
abstract:
- lang: eng
text: Thermoelectric materials are engines that convert heat into an electrical
current. Intuitively, the efficiency of this process depends on how many electrons
(charge carriers) can move and how easily they do so, how much energy those moving
electrons transport, and how easily the temperature gradient is maintained. In
terms of material properties, an excellent thermoelectric material requires a
high electrical conductivity σ, a high Seebeck coefficient S (a measure of the
induced thermoelectric voltage as a function of temperature gradient), and a low
thermal conductivity κ. The challenge is that these three properties are strongly
interrelated in a conflicting manner (1). On page 722 of this issue, Roychowdhury
et al. (2) have found a way to partially break these ties in silver antimony telluride
(AgSbTe2) with the addition of cadmium (Cd) cations, which increase the ordering
in this inherently disordered thermoelectric material.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
citation:
ama: Liu Y, Ibáñez M. Tidying up the mess. Science. 2021;371(6530):678-679.
doi:10.1126/science.abg0886
apa: Liu, Y., & Ibáñez, M. (2021). Tidying up the mess. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.abg0886
chicago: Liu, Yu, and Maria Ibáñez. “Tidying up the Mess.” Science. American
Association for the Advancement of Science, 2021. https://doi.org/10.1126/science.abg0886.
ieee: Y. Liu and M. Ibáñez, “Tidying up the mess,” Science, vol. 371, no.
6530. American Association for the Advancement of Science, pp. 678–679, 2021.
ista: Liu Y, Ibáñez M. 2021. Tidying up the mess. Science. 371(6530), 678–679.
mla: Liu, Yu, and Maria Ibáñez. “Tidying up the Mess.” Science, vol. 371,
no. 6530, American Association for the Advancement of Science, 2021, pp. 678–79,
doi:10.1126/science.abg0886.
short: Y. Liu, M. Ibáñez, Science 371 (2021) 678–679.
date_created: 2022-03-03T09:51:48Z
date_published: 2021-02-12T00:00:00Z
date_updated: 2023-08-17T07:00:35Z
day: '12'
department:
- _id: MaIb
doi: 10.1126/science.abg0886
external_id:
isi:
- '000617551600027'
pmid:
- '33574201'
intvolume: ' 371'
isi: 1
issue: '6530'
keyword:
- multidisciplinary
language:
- iso: eng
month: '02'
oa_version: None
page: 678-679
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tidying up the mess
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 371
year: '2021'
...
---
_id: '10858'
abstract:
- lang: eng
text: The cost-effective conversion of low-grade heat into electricity using thermoelectric
devices requires developing alternative materials and material processing technologies
able to reduce the currently high device manufacturing costs. In this direction,
thermoelectric materials that do not rely on rare or toxic elements such as tellurium
or lead need to be produced using high-throughput technologies not involving high
temperatures and long processes. Bi2Se3 is an obvious possible Te-free alternative
to Bi2Te3 for ambient temperature thermoelectric applications, but its performance
is still low for practical applications, and additional efforts toward finding
proper dopants are required. Here, we report a scalable method to produce Bi2Se3
nanosheets at low synthesis temperatures. We studied the influence of different
dopants on the thermoelectric properties of this material. Among the elements
tested, we demonstrated that Sn doping resulted in the best performance. Sn incorporation
resulted in a significant improvement to the Bi2Se3 Seebeck coefficient and a
reduction in the thermal conductivity in the direction of the hot-press axis,
resulting in an overall 60% improvement in the thermoelectric figure of merit
of Bi2Se3.
acknowledgement: "M.L., Y.Z., T.Z. and K.X. thank the China Scholarship Council for
their scholarship\r\nsupport. Y.L. acknowledges funding from the European Union’s
Horizon 2020 research and\r\ninnovation program under the Marie Sklodowska-Curie
grant agreement No. 754411. J.L. thanks the ICREA Academia program and projects
MICINN/FEDER RTI2018-093996-B-C31 and G.C. 2017 SGR 128. ICN2 acknowledges funding
from the Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO ENE2017-85087-C3."
article_number: '1827'
article_processing_charge: No
article_type: original
author:
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Ting
full_name: Zhang, Ting
last_name: Zhang
- first_name: Yong
full_name: Zuo, Yong
last_name: Zuo
- first_name: Ke
full_name: Xiao, Ke
last_name: Xiao
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Jordi
full_name: Llorca, Jordi
last_name: Llorca
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: Li M, Zhang Y, Zhang T, et al. Enhanced thermoelectric performance of n-type
Bi2Se3 nanosheets through Sn doping. Nanomaterials. 2021;11(7). doi:10.3390/nano11071827
apa: Li, M., Zhang, Y., Zhang, T., Zuo, Y., Xiao, K., Arbiol, J., … Cabot, A. (2021).
Enhanced thermoelectric performance of n-type Bi2Se3 nanosheets through Sn doping.
Nanomaterials. MDPI. https://doi.org/10.3390/nano11071827
chicago: Li, Mengyao, Yu Zhang, Ting Zhang, Yong Zuo, Ke Xiao, Jordi Arbiol, Jordi
Llorca, Yu Liu, and Andreu Cabot. “Enhanced Thermoelectric Performance of N-Type
Bi2Se3 Nanosheets through Sn Doping.” Nanomaterials. MDPI, 2021. https://doi.org/10.3390/nano11071827.
ieee: M. Li et al., “Enhanced thermoelectric performance of n-type Bi2Se3
nanosheets through Sn doping,” Nanomaterials, vol. 11, no. 7. MDPI, 2021.
ista: Li M, Zhang Y, Zhang T, Zuo Y, Xiao K, Arbiol J, Llorca J, Liu Y, Cabot A.
2021. Enhanced thermoelectric performance of n-type Bi2Se3 nanosheets through
Sn doping. Nanomaterials. 11(7), 1827.
mla: Li, Mengyao, et al. “Enhanced Thermoelectric Performance of N-Type Bi2Se3 Nanosheets
through Sn Doping.” Nanomaterials, vol. 11, no. 7, 1827, MDPI, 2021, doi:10.3390/nano11071827.
short: M. Li, Y. Zhang, T. Zhang, Y. Zuo, K. Xiao, J. Arbiol, J. Llorca, Y. Liu,
A. Cabot, Nanomaterials 11 (2021).
date_created: 2022-03-18T09:45:02Z
date_published: 2021-07-14T00:00:00Z
date_updated: 2023-08-17T07:08:30Z
day: '14'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.3390/nano11071827
ec_funded: 1
external_id:
isi:
- '000676570000001'
file:
- access_level: open_access
checksum: f28a8b5cf80f5605828359bb398463b0
content_type: application/pdf
creator: dernst
date_created: 2022-03-18T09:53:15Z
date_updated: 2022-03-18T09:53:15Z
file_id: '10859'
file_name: 2021_Nanomaterials_Li.pdf
file_size: 4867547
relation: main_file
success: 1
file_date_updated: 2022-03-18T09:53:15Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '7'
keyword:
- General Materials Science
- General Chemical Engineering
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nanomaterials
publication_identifier:
issn:
- 2079-4991
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Enhanced thermoelectric performance of n-type Bi2Se3 nanosheets through Sn
doping
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2021'
...
---
_id: '10834'
abstract:
- lang: eng
text: Hematopoietic-specific protein 1 (Hem1) is an essential subunit of the WAVE
regulatory complex (WRC) in immune cells. WRC is crucial for Arp2/3 complex activation
and the protrusion of branched actin filament networks. Moreover, Hem1 loss of
function in immune cells causes autoimmune diseases in humans. Here, we show that
genetic removal of Hem1 in macrophages diminishes frequency and efficacy of phagocytosis
as well as phagocytic cup formation in addition to defects in lamellipodial protrusion
and migration. Moreover, Hem1-null macrophages displayed strong defects in cell
adhesion despite unaltered podosome formation and concomitant extracellular matrix
degradation. Specifically, dynamics of both adhesion and de-adhesion as well as
concomitant phosphorylation of paxillin and focal adhesion kinase (FAK) were significantly
compromised. Accordingly, disruption of WRC function in non-hematopoietic cells
coincided with both defects in adhesion turnover and altered FAK and paxillin
phosphorylation. Consistently, platelets exhibited reduced adhesion and diminished
integrin αIIbβ3 activation upon WRC removal. Interestingly, adhesion phenotypes,
but not lamellipodia formation, were partially rescued by small molecule activation
of FAK. A full rescue of the phenotype, including lamellipodia formation, required
not only the presence of WRCs but also their binding to and activation by Rac.
Collectively, our results uncover that WRC impacts on integrin-dependent processes
in a FAK-dependent manner, controlling formation and dismantling of adhesions,
relevant for properly grabbing onto extracellular surfaces and particles during
cell edge expansion, like in migration or phagocytosis.
acknowledgement: We are grateful to Silvia Prettin, Ina Schleicher, and Petra Hagendorff
for expert technical assistance; David Dettbarn for animal keeping and breeding;
and Lothar Gröbe and Maria Höxter for cell sorting. We also thank Werner Tegge for
peptides and Giorgio Scita for antibodies. This work was supported, in part, by
the Deutsche Forschungsgemeinschaft (DFG), Priority Programm SPP1150 (to T.E.B.S.,
K.R., and M. Sixt), and by DFG grant GRK2223/1 (to K.R.). T.E.B.S. acknowledges
support by the Helmholtz Society through HGF impulse fund W2/W3-066 and M. Schnoor
by the Mexican Council for Science and Technology (CONACyT, 284292 ), Fund SEP-Cinvestav
( 108 ), and the Royal Society, UK (Newton Advanced Fellowship, NAF/R1/180017 ).
article_processing_charge: No
article_type: original
author:
- first_name: Stephanie
full_name: Stahnke, Stephanie
last_name: Stahnke
- first_name: Hermann
full_name: Döring, Hermann
last_name: Döring
- first_name: Charly
full_name: Kusch, Charly
last_name: Kusch
- first_name: David J.J.
full_name: de Gorter, David J.J.
last_name: de Gorter
- first_name: Sebastian
full_name: Dütting, Sebastian
last_name: Dütting
- first_name: Aleks
full_name: Guledani, Aleks
last_name: Guledani
- first_name: Irina
full_name: Pleines, Irina
last_name: Pleines
- first_name: Michael
full_name: Schnoor, Michael
last_name: Schnoor
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Robert
full_name: Geffers, Robert
last_name: Geffers
- first_name: Manfred
full_name: Rohde, Manfred
last_name: Rohde
- first_name: Mathias
full_name: Müsken, Mathias
last_name: Müsken
- first_name: Frieda
full_name: Kage, Frieda
last_name: Kage
- first_name: Anika
full_name: Steffen, Anika
last_name: Steffen
- first_name: Jan
full_name: Faix, Jan
last_name: Faix
- first_name: Bernhard
full_name: Nieswandt, Bernhard
last_name: Nieswandt
- first_name: Klemens
full_name: Rottner, Klemens
last_name: Rottner
- first_name: Theresia E.B.
full_name: Stradal, Theresia E.B.
last_name: Stradal
citation:
ama: Stahnke S, Döring H, Kusch C, et al. Loss of Hem1 disrupts macrophage function
and impacts migration, phagocytosis, and integrin-mediated adhesion. Current
Biology. 2021;31(10):2051-2064.e8. doi:10.1016/j.cub.2021.02.043
apa: Stahnke, S., Döring, H., Kusch, C., de Gorter, D. J. J., Dütting, S., Guledani,
A., … Stradal, T. E. B. (2021). Loss of Hem1 disrupts macrophage function and
impacts migration, phagocytosis, and integrin-mediated adhesion. Current Biology.
Elsevier. https://doi.org/10.1016/j.cub.2021.02.043
chicago: Stahnke, Stephanie, Hermann Döring, Charly Kusch, David J.J. de Gorter,
Sebastian Dütting, Aleks Guledani, Irina Pleines, et al. “Loss of Hem1 Disrupts
Macrophage Function and Impacts Migration, Phagocytosis, and Integrin-Mediated
Adhesion.” Current Biology. Elsevier, 2021. https://doi.org/10.1016/j.cub.2021.02.043.
ieee: S. Stahnke et al., “Loss of Hem1 disrupts macrophage function and impacts
migration, phagocytosis, and integrin-mediated adhesion,” Current Biology,
vol. 31, no. 10. Elsevier, p. 2051–2064.e8, 2021.
ista: Stahnke S, Döring H, Kusch C, de Gorter DJJ, Dütting S, Guledani A, Pleines
I, Schnoor M, Sixt MK, Geffers R, Rohde M, Müsken M, Kage F, Steffen A, Faix J,
Nieswandt B, Rottner K, Stradal TEB. 2021. Loss of Hem1 disrupts macrophage function
and impacts migration, phagocytosis, and integrin-mediated adhesion. Current Biology.
31(10), 2051–2064.e8.
mla: Stahnke, Stephanie, et al. “Loss of Hem1 Disrupts Macrophage Function and Impacts
Migration, Phagocytosis, and Integrin-Mediated Adhesion.” Current Biology,
vol. 31, no. 10, Elsevier, 2021, p. 2051–2064.e8, doi:10.1016/j.cub.2021.02.043.
short: S. Stahnke, H. Döring, C. Kusch, D.J.J. de Gorter, S. Dütting, A. Guledani,
I. Pleines, M. Schnoor, M.K. Sixt, R. Geffers, M. Rohde, M. Müsken, F. Kage, A.
Steffen, J. Faix, B. Nieswandt, K. Rottner, T.E.B. Stradal, Current Biology 31
(2021) 2051–2064.e8.
date_created: 2022-03-08T07:51:04Z
date_published: 2021-05-24T00:00:00Z
date_updated: 2023-08-17T07:01:14Z
day: '24'
department:
- _id: MiSi
doi: 10.1016/j.cub.2021.02.043
external_id:
isi:
- '000654652200002'
pmid:
- '33711252'
intvolume: ' 31'
isi: 1
issue: '10'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.03.24.005835
month: '05'
oa: 1
oa_version: Preprint
page: 2051-2064.e8
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis,
and integrin-mediated adhesion
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 31
year: '2021'
...