---
_id: '15171'
abstract:
- lang: eng
text: The brain’s functionality is developed and maintained through synaptic plasticity.
As synapses undergo plasticity, they also affect each other. The nature of such
‘co-dependency’ is difficult to disentangle experimentally, because multiple synapses
must be monitored simultaneously. To help understand the experimentally observed
phenomena, we introduce a framework that formalizes synaptic co-dependency between
different connection types. The resulting model explains how inhibition can gate
excitatory plasticity while neighboring excitatory–excitatory interactions determine
the strength of long-term potentiation. Furthermore, we show how the interplay
between excitatory and inhibitory synapses can account for the quick rise and
long-term stability of a variety of synaptic weight profiles, such as orientation
tuning and dendritic clustering of co-active synapses. In recurrent neuronal networks,
co-dependent plasticity produces rich and stable motor cortex-like dynamics with
high input sensitivity. Our results suggest an essential role for the neighborly
synaptic interaction during learning, connecting micro-level physiology with network-wide
phenomena.
acknowledgement: We thank C. Currin, B. Podlaski and the members of the Vogels group
for fruitful discussions. E.J.A. and T.P.V. were supported by a Research Project
Grant from the Leverhulme Trust (RPG-2016-446; TPV), a Sir Henry Dale Fellowship
from the Wellcome Trust and the Royal Society (WT100000; T.P.V.), a Wellcome Trust
Senior Research Fellowship (214316/Z/18/Z; T.P.V.) and a European Research Council
Consolidator Grant (SYNAPSEEK, 819603; T.P.V.). For the purpose of open access,
the authors have applied a CC BY public copyright license to any author accepted
manuscript version arising from this submission. Open access funding provided by
University of Basel.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Everton J.
full_name: Agnes, Everton J.
last_name: Agnes
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
citation:
ama: Agnes EJ, Vogels TP. Co-dependent excitatory and inhibitory plasticity accounts
for quick, stable and long-lasting memories in biological networks. Nature
Neuroscience. 2024. doi:10.1038/s41593-024-01597-4
apa: Agnes, E. J., & Vogels, T. P. (2024). Co-dependent excitatory and inhibitory
plasticity accounts for quick, stable and long-lasting memories in biological
networks. Nature Neuroscience. Springer Nature. https://doi.org/10.1038/s41593-024-01597-4
chicago: Agnes, Everton J., and Tim P Vogels. “Co-Dependent Excitatory and Inhibitory
Plasticity Accounts for Quick, Stable and Long-Lasting Memories in Biological
Networks.” Nature Neuroscience. Springer Nature, 2024. https://doi.org/10.1038/s41593-024-01597-4.
ieee: E. J. Agnes and T. P. Vogels, “Co-dependent excitatory and inhibitory plasticity
accounts for quick, stable and long-lasting memories in biological networks,”
Nature Neuroscience. Springer Nature, 2024.
ista: Agnes EJ, Vogels TP. 2024. Co-dependent excitatory and inhibitory plasticity
accounts for quick, stable and long-lasting memories in biological networks. Nature
Neuroscience.
mla: Agnes, Everton J., and Tim P. Vogels. “Co-Dependent Excitatory and Inhibitory
Plasticity Accounts for Quick, Stable and Long-Lasting Memories in Biological
Networks.” Nature Neuroscience, Springer Nature, 2024, doi:10.1038/s41593-024-01597-4.
short: E.J. Agnes, T.P. Vogels, Nature Neuroscience (2024).
date_created: 2024-03-24T23:01:00Z
date_published: 2024-03-20T00:00:00Z
date_updated: 2024-03-25T07:04:05Z
day: '20'
department:
- _id: TiVo
doi: 10.1038/s41593-024-01597-4
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41593-024-01597-4
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 0aacfa84-070f-11eb-9043-d7eb2c709234
call_identifier: H2020
grant_number: '819603'
name: Learning the shape of synaptic plasticity rules for neuronal architectures
and function through machine learning.
publication: Nature Neuroscience
publication_identifier:
eissn:
- 1546-1726
issn:
- 1097-6256
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Co-dependent excitatory and inhibitory plasticity accounts for quick, stable
and long-lasting memories in biological networks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
_id: '15172'
abstract:
- lang: eng
text: 'We propose a novel approach to concentration for non-independent random variables.
The main idea is to “pretend” that the random variables are independent and pay
a multiplicative price measuring how far they are from actually being independent.
This price is encapsulated in the Hellinger integral between the joint and the
product of the marginals, which is then upper bounded leveraging tensorisation
properties. Our bounds represent a natural generalisation of concentration inequalities
in the presence of dependence: we recover exactly the classical bounds (McDiarmid’s
inequality) when the random variables are independent. Furthermore, in a “large
deviations” regime, we obtain the same decay in the probability as for the independent
case, even when the random variables display non-trivial dependencies. To show
this, we consider a number of applications of interest. First, we provide a bound
for Markov chains with finite state space. Then, we consider the Simple Symmetric
Random Walk, which is a non-contracting Markov chain, and a non-Markovian setting
in which the stochastic process depends on its entire past. To conclude, we propose
an application to Markov Chain Monte Carlo methods, where our approach leads to
an improved lower bound on the minimum burn-in period required to reach a certain
accuracy. In all of these settings, we provide a regime of parameters in which
our bound fares better than what the state of the art can provide.'
article_processing_charge: No
article_type: original
author:
- first_name: Amedeo Roberto
full_name: Esposito, Amedeo Roberto
id: 9583e921-e1ad-11ec-9862-cef099626dc9
last_name: Esposito
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
citation:
ama: Esposito AR, Mondelli M. Concentration without independence via information
measures. IEEE Transactions on Information Theory. doi:10.1109/TIT.2024.3367767
apa: Esposito, A. R., & Mondelli, M. (n.d.). Concentration without independence
via information measures. IEEE Transactions on Information Theory. IEEE.
https://doi.org/10.1109/TIT.2024.3367767
chicago: Esposito, Amedeo Roberto, and Marco Mondelli. “Concentration without Independence
via Information Measures.” IEEE Transactions on Information Theory. IEEE,
n.d. https://doi.org/10.1109/TIT.2024.3367767.
ieee: A. R. Esposito and M. Mondelli, “Concentration without independence via information
measures,” IEEE Transactions on Information Theory. IEEE.
ista: Esposito AR, Mondelli M. Concentration without independence via information
measures. IEEE Transactions on Information Theory.
mla: Esposito, Amedeo Roberto, and Marco Mondelli. “Concentration without Independence
via Information Measures.” IEEE Transactions on Information Theory, IEEE,
doi:10.1109/TIT.2024.3367767.
short: A.R. Esposito, M. Mondelli, IEEE Transactions on Information Theory (n.d.).
date_created: 2024-03-24T23:01:00Z
date_published: 2024-02-20T00:00:00Z
date_updated: 2024-03-25T07:15:51Z
day: '20'
department:
- _id: MaMo
doi: 10.1109/TIT.2024.3367767
external_id:
arxiv:
- '2303.07245'
language:
- iso: eng
month: '02'
oa_version: None
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: IEEE Transactions on Information Theory
publication_identifier:
eissn:
- 1557-9654
issn:
- 0018-9448
publication_status: inpress
publisher: IEEE
quality_controlled: '1'
related_material:
record:
- id: '14922'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Concentration without independence via information measures
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
_id: '15170'
abstract:
- lang: eng
text: 'The James Webb Space Telescope is revealing a new population of dust-reddened
broad-line active galactic nuclei (AGN) at redshifts z ≳ 5. Here we present deep
NIRSpec/Prism spectroscopy from the Cycle 1 Treasury program Ultradeep NIRSpec
and NIRCam ObserVations before the Epoch of Reionization (UNCOVER) of 15 AGN candidates
selected to be compact, with red continua in the rest-frame optical but with blue
slopes in the UV. From NIRCam photometry alone, they could have been dominated
by dusty star formation or an AGN. Here we show that the majority of the compact
red sources in UNCOVER are dust-reddened AGN: 60% show definitive evidence for
broad-line Hα with a FWHM > 2000 km s −1, 20% of the current data are inconclusive,
and 20% are brown dwarf stars. We propose an updated photometric criterion to
select red z > 5 AGN that excludes brown dwarfs and is expected to yield >80%
AGN. Remarkably, among all zphot > 5 galaxies with F277W – F444W > 1 in UNCOVER
at least 33% are AGN regardless of compactness, climbing to at least 80% AGN for
sources with F277W – F444W > 1.6. The confirmed AGN have black hole masses of
107–109M⊙. While their UV luminosities (−16 > MUV > −20 AB mag) are low compared
to UV-selected AGN at these epochs, consistent with percent-level scattered AGN
light or low levels of unobscured star formation, the inferred bolometric luminosities
are typical of 107–109M⊙ black holes radiating at ∼10%–40% the Eddington limit.
The number densities are surprisingly high at ∼10−5 Mpc−3 mag−1, 100 times more
common than the faintest UV-selected quasars, while accounting for ∼1% of the
UV-selected galaxies. While their UV faintness suggests they may not contribute
strongly to reionization, their ubiquity poses challenges to models of black hole
growth.'
acknowledgement: J.E.G. and A.D.G acknowledge support from NSF/AAG grant No. 1007094,
and J.E.G. also acknowledges support from NSF/AAG grant No. 1007052. A.Z. acknowledges
support by grant No. 2020750 from the United States-Israel Binational Science Foundation
(BSF) and grant No. 2109066 from the United States National Science Foundation (NSF),
and by the Ministry of Science & Technology of Israel. The Cosmic Dawn Center is
funded by the Danish National Research Foundation (DNRF) under grant No. 140. This
work has received funding from the Swiss State Secretariat for Education, Research
and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss
National Science Foundation (SNSF) through project grant 200020_207349. P.D. acknowledges
support from the NWO grant 016.VIDI.189.162 ("ODIN") and from the European Commission's
and University of Groningen's CO-FUND Rosalind Franklin program. K.G. and T.N. acknowledge
support from Australian Research Council Laureate Fellowship FL180100060. H.A. and
I.C. acknowledge support from CNES, focused on the JWST mission, and the Programme
National Cosmology and Galaxies (PNCG) of CNRS/INSU with INP and IN2P3, cofunded
by CEA and CNES. R.P.N. acknowledges funding from JWST programs GO-1933 and GO-2279.
Support for this work was provided by NASA through the NASA Hubble Fellowship grant
HST-HF2-51515.001-A awarded by the Space Telescope Science Institute, which is operated
by the Association of Universities for Research in Astronomy, Incorporated, under
NASA contract NAS5-26555. The research of C.C.W. is supported by NOIRLab, which
is managed by the Association of Universities for Research in Astronomy (AURA) under
a cooperative agreement with the National Science Foundation. B.W. acknowledges
support from JWST-GO-02561.022-A. A.J.B. acknowledges funding support from NASA/ADAP
grant 21-ADAP21-0187. Support for this work was provided by The Brinson Foundation
through a Brinson Prize Fellowship grant. R.P.N. acknowledges support for this work
provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded
by the Space Telescope Science Institute, which is operated by the Association of
Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555.
C.P. thanks Marsha and Ralph Schilling for the generous support of this research.
article_number: '39'
article_processing_charge: Yes
article_type: original
author:
- first_name: Jenny E.
full_name: Greene, Jenny E.
last_name: Greene
- first_name: Ivo
full_name: Labbe, Ivo
last_name: Labbe
- first_name: Andy D.
full_name: Goulding, Andy D.
last_name: Goulding
- first_name: Lukas J.
full_name: Furtak, Lukas J.
last_name: Furtak
- first_name: Iryna
full_name: Chemerynska, Iryna
last_name: Chemerynska
- first_name: Vasily
full_name: Kokorev, Vasily
last_name: Kokorev
- first_name: Pratika
full_name: Dayal, Pratika
last_name: Dayal
- first_name: Marta
full_name: Volonteri, Marta
last_name: Volonteri
- first_name: Christina C.
full_name: Williams, Christina C.
last_name: Williams
- first_name: Bingjie
full_name: Wang, Bingjie
last_name: Wang
- first_name: David J.
full_name: Setton, David J.
last_name: Setton
- first_name: Adam J.
full_name: Burgasser, Adam J.
last_name: Burgasser
- first_name: Rachel
full_name: Bezanson, Rachel
last_name: Bezanson
- first_name: Hakim
full_name: Atek, Hakim
last_name: Atek
- first_name: Gabriel
full_name: Brammer, Gabriel
last_name: Brammer
- first_name: Sam E.
full_name: Cutler, Sam E.
last_name: Cutler
- first_name: Robert
full_name: Feldmann, Robert
last_name: Feldmann
- first_name: Seiji
full_name: Fujimoto, Seiji
last_name: Fujimoto
- first_name: Karl
full_name: Glazebrook, Karl
last_name: Glazebrook
- first_name: Anna
full_name: De Graaff, Anna
last_name: De Graaff
- first_name: Gourav
full_name: Khullar, Gourav
last_name: Khullar
- first_name: Joel
full_name: Leja, Joel
last_name: Leja
- first_name: Danilo
full_name: Marchesini, Danilo
last_name: Marchesini
- first_name: Michael V.
full_name: Maseda, Michael V.
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Tim B.
full_name: Miller, Tim B.
last_name: Miller
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Pascal A.
full_name: Oesch, Pascal A.
last_name: Oesch
- first_name: Richard
full_name: Pan, Richard
last_name: Pan
- first_name: Casey
full_name: Papovich, Casey
last_name: Papovich
- first_name: Sedona H.
full_name: Price, Sedona H.
last_name: Price
- first_name: Pieter
full_name: Van Dokkum, Pieter
last_name: Van Dokkum
- first_name: John R.
full_name: Weaver, John R.
last_name: Weaver
- first_name: Katherine E.
full_name: Whitaker, Katherine E.
last_name: Whitaker
- first_name: Adi
full_name: Zitrin, Adi
last_name: Zitrin
citation:
ama: Greene JE, Labbe I, Goulding AD, et al. UNCOVER spectroscopy confirms the surprising
ubiquity of active galactic nuclei in red sources at z > 5. Astrophysical
Journal. 2024;964. doi:10.3847/1538-4357/ad1e5f
apa: Greene, J. E., Labbe, I., Goulding, A. D., Furtak, L. J., Chemerynska, I.,
Kokorev, V., … Zitrin, A. (2024). UNCOVER spectroscopy confirms the surprising
ubiquity of active galactic nuclei in red sources at z > 5. Astrophysical
Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ad1e5f
chicago: Greene, Jenny E., Ivo Labbe, Andy D. Goulding, Lukas J. Furtak, Iryna Chemerynska,
Vasily Kokorev, Pratika Dayal, et al. “UNCOVER Spectroscopy Confirms the Surprising
Ubiquity of Active Galactic Nuclei in Red Sources at z > 5.” Astrophysical
Journal. IOP Publishing, 2024. https://doi.org/10.3847/1538-4357/ad1e5f.
ieee: J. E. Greene et al., “UNCOVER spectroscopy confirms the surprising
ubiquity of active galactic nuclei in red sources at z > 5,” Astrophysical
Journal, vol. 964. IOP Publishing, 2024.
ista: Greene JE, Labbe I, Goulding AD, Furtak LJ, Chemerynska I, Kokorev V, Dayal
P, Volonteri M, Williams CC, Wang B, Setton DJ, Burgasser AJ, Bezanson R, Atek
H, Brammer G, Cutler SE, Feldmann R, Fujimoto S, Glazebrook K, De Graaff A, Khullar
G, Leja J, Marchesini D, Maseda MV, Matthee JJ, Miller TB, Naidu RP, Nanayakkara
T, Oesch PA, Pan R, Papovich C, Price SH, Van Dokkum P, Weaver JR, Whitaker KE,
Zitrin A. 2024. UNCOVER spectroscopy confirms the surprising ubiquity of active
galactic nuclei in red sources at z > 5. Astrophysical Journal. 964, 39.
mla: Greene, Jenny E., et al. “UNCOVER Spectroscopy Confirms the Surprising Ubiquity
of Active Galactic Nuclei in Red Sources at z > 5.” Astrophysical Journal,
vol. 964, 39, IOP Publishing, 2024, doi:10.3847/1538-4357/ad1e5f.
short: J.E. Greene, I. Labbe, A.D. Goulding, L.J. Furtak, I. Chemerynska, V. Kokorev,
P. Dayal, M. Volonteri, C.C. Williams, B. Wang, D.J. Setton, A.J. Burgasser, R.
Bezanson, H. Atek, G. Brammer, S.E. Cutler, R. Feldmann, S. Fujimoto, K. Glazebrook,
A. De Graaff, G. Khullar, J. Leja, D. Marchesini, M.V. Maseda, J.J. Matthee, T.B.
Miller, R.P. Naidu, T. Nanayakkara, P.A. Oesch, R. Pan, C. Papovich, S.H. Price,
P. Van Dokkum, J.R. Weaver, K.E. Whitaker, A. Zitrin, Astrophysical Journal 964
(2024).
date_created: 2024-03-24T23:00:59Z
date_published: 2024-03-01T00:00:00Z
date_updated: 2024-03-25T08:04:13Z
day: '01'
ddc:
- '550'
department:
- _id: JoMa
doi: 10.3847/1538-4357/ad1e5f
external_id:
arxiv:
- '2309.05714'
file:
- access_level: open_access
checksum: 389a880e176799d5c062ea7cb82d08c9
content_type: application/pdf
creator: dernst
date_created: 2024-03-25T08:02:43Z
date_updated: 2024-03-25T08:02:43Z
file_id: '15176'
file_name: 2024_AstrophysicalJourn_Greene.pdf
file_size: 2700137
relation: main_file
success: 1
file_date_updated: 2024-03-25T08:02:43Z
has_accepted_license: '1'
intvolume: ' 964'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: UNCOVER spectroscopy confirms the surprising ubiquity of active galactic nuclei
in red sources at z > 5
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 964
year: '2024'
...
---
_id: '15168'
abstract:
- lang: eng
text: 'A linearly ordered (LO) k-colouring of a hypergraph is a colouring of its
vertices with colours 1, … , k such that each edge contains a unique maximal colour.
Deciding whether an input hypergraph admits LO k-colouring with a fixed number
of colours is NP-complete (and in the special case of graphs, LO colouring coincides
with the usual graph colouring). Here, we investigate the complexity of approximating
the "linearly ordered chromatic number" of a hypergraph. We prove that the following
promise problem is NP-complete: Given a 3-uniform hypergraph, distinguish between
the case that it is LO 3-colourable, and the case that it is not even LO 4-colourable.
We prove this result by a combination of algebraic, topological, and combinatorial
methods, building on and extending a topological approach for studying approximate
graph colouring introduced by Krokhin, Opršal, Wrochna, and Živný (2023).'
acknowledgement: "Marek Filakovský: This research was supported by Charles University
(project PRIMUS/\r\n21/SCI/014), the Austrian Science Fund (FWF project P31312-N35),
and MSCAfellow5_MUNI\r\n(CZ.02.01.01/00/22_010/0003229). Tamio-Vesa Nakajima: This
research was funded by UKRI EP/X024431/1 and by a Clarendon Fund Scholarship. All
data is provided in full in the results section of this paper. Jakub Opršal: This
project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie Grant Agreement No 101034413.
Uli Wagner: This research was supported by the Austrian Science Fund (FWF project
P31312-N35)."
alternative_title:
- LIPIcs
article_number: '34'
article_processing_charge: No
author:
- first_name: Marek
full_name: Filakovský, Marek
id: 3E8AF77E-F248-11E8-B48F-1D18A9856A87
last_name: Filakovský
- first_name: Tamio Vesa
full_name: Nakajima, Tamio Vesa
last_name: Nakajima
- first_name: Jakub
full_name: Opršal, Jakub
id: ec596741-c539-11ec-b829-c79322a91242
last_name: Opršal
orcid: 0000-0003-1245-3456
- first_name: Gianluca
full_name: Tasinato, Gianluca
id: 0433290C-AF8F-11E9-A4C7-F729E6697425
last_name: Tasinato
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: 'Filakovský M, Nakajima TV, Opršal J, Tasinato G, Wagner U. Hardness of linearly
ordered 4-colouring of 3-colourable 3-uniform hypergraphs. In: 41st International
Symposium on Theoretical Aspects of Computer Science. Vol 289. Schloss Dagstuhl
- Leibniz-Zentrum für Informatik; 2024. doi:10.4230/LIPIcs.STACS.2024.34'
apa: 'Filakovský, M., Nakajima, T. V., Opršal, J., Tasinato, G., & Wagner, U.
(2024). Hardness of linearly ordered 4-colouring of 3-colourable 3-uniform hypergraphs.
In 41st International Symposium on Theoretical Aspects of Computer Science
(Vol. 289). Clermont-Ferrand, France: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
https://doi.org/10.4230/LIPIcs.STACS.2024.34'
chicago: Filakovský, Marek, Tamio Vesa Nakajima, Jakub Opršal, Gianluca Tasinato,
and Uli Wagner. “Hardness of Linearly Ordered 4-Colouring of 3-Colourable 3-Uniform
Hypergraphs.” In 41st International Symposium on Theoretical Aspects of Computer
Science, Vol. 289. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024.
https://doi.org/10.4230/LIPIcs.STACS.2024.34.
ieee: M. Filakovský, T. V. Nakajima, J. Opršal, G. Tasinato, and U. Wagner, “Hardness
of linearly ordered 4-colouring of 3-colourable 3-uniform hypergraphs,” in 41st
International Symposium on Theoretical Aspects of Computer Science, Clermont-Ferrand,
France, 2024, vol. 289.
ista: 'Filakovský M, Nakajima TV, Opršal J, Tasinato G, Wagner U. 2024. Hardness
of linearly ordered 4-colouring of 3-colourable 3-uniform hypergraphs. 41st International
Symposium on Theoretical Aspects of Computer Science. STACS: Symposium on Theoretical
Aspects of Computer Science, LIPIcs, vol. 289, 34.'
mla: Filakovský, Marek, et al. “Hardness of Linearly Ordered 4-Colouring of 3-Colourable
3-Uniform Hypergraphs.” 41st International Symposium on Theoretical Aspects
of Computer Science, vol. 289, 34, Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 2024, doi:10.4230/LIPIcs.STACS.2024.34.
short: M. Filakovský, T.V. Nakajima, J. Opršal, G. Tasinato, U. Wagner, in:, 41st
International Symposium on Theoretical Aspects of Computer Science, Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 2024.
conference:
end_date: 2024-03-14
location: Clermont-Ferrand, France
name: 'STACS: Symposium on Theoretical Aspects of Computer Science'
start_date: 2024-03-12
date_created: 2024-03-24T23:00:59Z
date_published: 2024-03-01T00:00:00Z
date_updated: 2024-03-25T07:45:54Z
day: '01'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.STACS.2024.34
ec_funded: 1
external_id:
arxiv:
- '2312.12981'
file:
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date_created: 2024-03-25T07:44:30Z
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file_name: 2024_LIPICs_Filakovsky.pdf
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file_date_updated: 2024-03-25T07:44:30Z
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language:
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month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 26611F5C-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31312
name: Algorithms for Embeddings and Homotopy Theory
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: 41st International Symposium on Theoretical Aspects of Computer Science
publication_identifier:
eissn:
- 1868-8969
isbn:
- '9783959773119'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hardness of linearly ordered 4-colouring of 3-colourable 3-uniform hypergraphs
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 289
year: '2024'
...
---
_id: '15164'
abstract:
- lang: eng
text: Primary implant stability, which refers to the stability of the implant during
the initial healing period is a crucial factor in determining the long-term success
of the implant and lays the foundation for secondary implant stability achieved
through osseointegration. Factors affecting primary stability include implant
design, surgical technique, and patient-specific factors like bone quality and
morphology. In vivo, the cyclic nature of anatomical loading puts osteosynthesis
locking screws under dynamic loads, which can lead to the formation of micro cracks
and defects that slowly degrade the mechanical connection between the bone and
screw, thus compromising the initial stability and secondary stability of the
implant. Monotonic quasi-static loading used for testing the holding capacity
of implanted screws is not well suited to capture this behavior since it cannot
capture the progressive deterioration of peri‑implant bone at small displacements.
In order to address this issue, this study aims to determine a critical point
of loss of primary implant stability in osteosynthesis locking screws under cyclic
overloading by investigating the evolution of damage, dissipated energy, and permanent
deformation. A custom-made test setup was used to test implanted 2.5 mm locking
screws under cyclic overloading test. For each loading cycle, maximum forces and
displacement were recorded as well as initial and final cycle displacements and
used to calculate damage and energy dissipation evolution. The results of this
study demonstrate that for axial, shear, and mixed loading significant damage
and energy dissipation can be observed at approximately 20 % of the failure force.
Additionally, at this load level, permanent deformations on the screw-bone interface
were found to be in the range of 50 to 150 mm which promotes osseointegration
and secondary implant stability. This research can assist surgeons in making informed
preoperative decisions by providing a better understanding of the critical point
of loss of primary implant stability, thus improving the long-term success of
the implant and overall patient satisfaction.
acknowledgement: The authors declare no conflict of interest related to this study.
This project was funded by the Gesellschaft fuer Forschungsfoerderung Niederoesterreich
m.b.H. Life Science Call 2017 Grant No. LS17004 and Science call 2019 Dissertationen
Grant No. SC19014. No ethical approval was required for this study.
article_number: '104143'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Juan D.
full_name: Silva-Henao, Juan D.
last_name: Silva-Henao
- first_name: Sophie
full_name: Schober, Sophie
id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8
last_name: Schober
- first_name: Dieter H.
full_name: Pahr, Dieter H.
last_name: Pahr
- first_name: Andreas G.
full_name: Reisinger, Andreas G.
last_name: Reisinger
citation:
ama: Silva-Henao JD, Schober S, Pahr DH, Reisinger AG. Critical loss of primary
implant stability in osteosynthesis locking screws under cyclic overloading. Medical
Engineering and Physics. 2024;126. doi:10.1016/j.medengphy.2024.104143
apa: Silva-Henao, J. D., Schober, S., Pahr, D. H., & Reisinger, A. G. (2024).
Critical loss of primary implant stability in osteosynthesis locking screws under
cyclic overloading. Medical Engineering and Physics. Elsevier. https://doi.org/10.1016/j.medengphy.2024.104143
chicago: Silva-Henao, Juan D., Sophie Schober, Dieter H. Pahr, and Andreas G. Reisinger.
“Critical Loss of Primary Implant Stability in Osteosynthesis Locking Screws under
Cyclic Overloading.” Medical Engineering and Physics. Elsevier, 2024. https://doi.org/10.1016/j.medengphy.2024.104143.
ieee: J. D. Silva-Henao, S. Schober, D. H. Pahr, and A. G. Reisinger, “Critical
loss of primary implant stability in osteosynthesis locking screws under cyclic
overloading,” Medical Engineering and Physics, vol. 126. Elsevier, 2024.
ista: Silva-Henao JD, Schober S, Pahr DH, Reisinger AG. 2024. Critical loss of primary
implant stability in osteosynthesis locking screws under cyclic overloading. Medical
Engineering and Physics. 126, 104143.
mla: Silva-Henao, Juan D., et al. “Critical Loss of Primary Implant Stability in
Osteosynthesis Locking Screws under Cyclic Overloading.” Medical Engineering
and Physics, vol. 126, 104143, Elsevier, 2024, doi:10.1016/j.medengphy.2024.104143.
short: J.D. Silva-Henao, S. Schober, D.H. Pahr, A.G. Reisinger, Medical Engineering
and Physics 126 (2024).
date_created: 2024-03-24T23:00:58Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2024-03-25T08:31:01Z
day: '01'
ddc:
- '610'
department:
- _id: PreCl
doi: 10.1016/j.medengphy.2024.104143
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checksum: 974acbf2731e7382dcf5920ac762e551
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creator: dernst
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date_updated: 2024-03-25T08:29:52Z
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file_name: 2024_MedEngineeringPhysics_SilvaHenao.pdf
file_size: 10039402
relation: main_file
success: 1
file_date_updated: 2024-03-25T08:29:52Z
has_accepted_license: '1'
intvolume: ' 126'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Medical Engineering and Physics
publication_identifier:
eissn:
- 1873-4030
issn:
- 1350-4533
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Critical loss of primary implant stability in osteosynthesis locking screws
under cyclic overloading
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 126
year: '2024'
...