---
_id: '6451'
abstract:
- lang: eng
text: Epidermal growth factor receptor (EGFR) signaling controls skin development
and homeostasis inmice and humans, and its deficiency causes severe skin inflammation,
which might affect epidermalstem cell behavior. Here, we describe the inflammation-independent
effects of EGFR deficiency dur-ing skin morphogenesis and in adult hair follicle
stem cells. Expression and alternative splicing analysisof RNA sequencing data
from interfollicular epidermis and outer root sheath indicate that EGFR con-trols
genes involved in epidermal differentiation and also in centrosome function, DNA
damage, cellcycle, and apoptosis. Genetic experiments employingp53deletion in
EGFR-deficient epidermis revealthat EGFR signaling exhibitsp53-dependent functions
in proliferative epidermal compartments, aswell asp53-independent functions in
differentiated hair shaft keratinocytes. Loss of EGFR leads toabsence of LEF1
protein specifically in the innermost epithelial hair layers, resulting in disorganizationof
medulla cells. Thus, our results uncover important spatial and temporal features
of cell-autonomousEGFR functions in the epidermis.
article_processing_charge: No
author:
- first_name: Nicole
full_name: Amberg, Nicole
id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
last_name: Amberg
orcid: 0000-0002-3183-8207
- first_name: Panagiota A.
full_name: Sotiropoulou, Panagiota A.
last_name: Sotiropoulou
- first_name: Gerwin
full_name: Heller, Gerwin
last_name: Heller
- first_name: Beate M.
full_name: Lichtenberger, Beate M.
last_name: Lichtenberger
- first_name: Martin
full_name: Holcmann, Martin
last_name: Holcmann
- first_name: Bahar
full_name: Camurdanoglu, Bahar
last_name: Camurdanoglu
- first_name: Temenuschka
full_name: Baykuscheva-Gentscheva, Temenuschka
last_name: Baykuscheva-Gentscheva
- first_name: Cedric
full_name: Blanpain, Cedric
last_name: Blanpain
- first_name: Maria
full_name: Sibilia, Maria
last_name: Sibilia
citation:
ama: Amberg N, Sotiropoulou PA, Heller G, et al. EGFR controls hair shaft differentiation
in a p53-independent manner. iScience. 2019;15:243-256. doi:10.1016/j.isci.2019.04.018
apa: Amberg, N., Sotiropoulou, P. A., Heller, G., Lichtenberger, B. M., Holcmann,
M., Camurdanoglu, B., … Sibilia, M. (2019). EGFR controls hair shaft differentiation
in a p53-independent manner. IScience. Elsevier. https://doi.org/10.1016/j.isci.2019.04.018
chicago: Amberg, Nicole, Panagiota A. Sotiropoulou, Gerwin Heller, Beate M. Lichtenberger,
Martin Holcmann, Bahar Camurdanoglu, Temenuschka Baykuscheva-Gentscheva, Cedric
Blanpain, and Maria Sibilia. “EGFR Controls Hair Shaft Differentiation in a P53-Independent
Manner.” IScience. Elsevier, 2019. https://doi.org/10.1016/j.isci.2019.04.018.
ieee: N. Amberg et al., “EGFR controls hair shaft differentiation in a p53-independent
manner,” iScience, vol. 15. Elsevier, pp. 243–256, 2019.
ista: Amberg N, Sotiropoulou PA, Heller G, Lichtenberger BM, Holcmann M, Camurdanoglu
B, Baykuscheva-Gentscheva T, Blanpain C, Sibilia M. 2019. EGFR controls hair shaft
differentiation in a p53-independent manner. iScience. 15, 243–256.
mla: Amberg, Nicole, et al. “EGFR Controls Hair Shaft Differentiation in a P53-Independent
Manner.” IScience, vol. 15, Elsevier, 2019, pp. 243–56, doi:10.1016/j.isci.2019.04.018.
short: N. Amberg, P.A. Sotiropoulou, G. Heller, B.M. Lichtenberger, M. Holcmann,
B. Camurdanoglu, T. Baykuscheva-Gentscheva, C. Blanpain, M. Sibilia, IScience
15 (2019) 243–256.
date_created: 2019-05-14T11:47:40Z
date_published: 2019-05-31T00:00:00Z
date_updated: 2023-09-08T11:38:04Z
day: '31'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.isci.2019.04.018
external_id:
isi:
- '000470104600022'
file:
- access_level: open_access
checksum: a9ad2296726c9474ad5860c9c2f53622
content_type: application/pdf
creator: dernst
date_created: 2019-05-14T11:51:51Z
date_updated: 2020-07-14T12:47:30Z
file_id: '6452'
file_name: 2019_iScience_Amberg.pdf
file_size: 8365970
relation: main_file
file_date_updated: 2020-07-14T12:47:30Z
has_accepted_license: '1'
intvolume: ' 15'
isi: 1
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 243-256
publication: iScience
publication_identifier:
issn:
- 2589-0042
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: EGFR controls hair shaft differentiation in a p53-independent manner
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 15
year: '2019'
...
---
_id: '10879'
abstract:
- lang: eng
text: We study effects of a bounded and compactly supported perturbation on multidimensional
continuum random Schrödinger operators in the region of complete localisation.
Our main emphasis is on Anderson orthogonality for random Schrödinger operators.
Among others, we prove that Anderson orthogonality does occur for Fermi energies
in the region of complete localisation with a non-zero probability. This partially
confirms recent non-rigorous findings [V. Khemani et al., Nature Phys. 11 (2015),
560–565]. The spectral shift function plays an important role in our analysis
of Anderson orthogonality. We identify it with the index of the corresponding
pair of spectral projections and explore the consequences thereof. All our results
rely on the main technical estimate of this paper which guarantees separate exponential
decay of the disorder-averaged Schatten p-norm of χa(f(H)−f(Hτ))χb in a and b.
Here, Hτ is a perturbation of the random Schrödinger operator H, χa is the multiplication
operator corresponding to the indicator function of a unit cube centred about
a∈Rd, and f is in a suitable class of functions of bounded variation with distributional
derivative supported in the region of complete localisation for H.
acknowledgement: M.G. was supported by the DFG under grant GE 2871/1-1.
article_processing_charge: No
article_type: original
author:
- first_name: Adrian M
full_name: Dietlein, Adrian M
id: 317CB464-F248-11E8-B48F-1D18A9856A87
last_name: Dietlein
- first_name: Martin
full_name: Gebert, Martin
last_name: Gebert
- first_name: Peter
full_name: Müller, Peter
last_name: Müller
citation:
ama: Dietlein AM, Gebert M, Müller P. Perturbations of continuum random Schrödinger
operators with applications to Anderson orthogonality and the spectral shift function.
Journal of Spectral Theory. 2019;9(3):921-965. doi:10.4171/jst/267
apa: Dietlein, A. M., Gebert, M., & Müller, P. (2019). Perturbations of continuum
random Schrödinger operators with applications to Anderson orthogonality and the
spectral shift function. Journal of Spectral Theory. European Mathematical
Society Publishing House. https://doi.org/10.4171/jst/267
chicago: Dietlein, Adrian M, Martin Gebert, and Peter Müller. “Perturbations of
Continuum Random Schrödinger Operators with Applications to Anderson Orthogonality
and the Spectral Shift Function.” Journal of Spectral Theory. European
Mathematical Society Publishing House, 2019. https://doi.org/10.4171/jst/267.
ieee: A. M. Dietlein, M. Gebert, and P. Müller, “Perturbations of continuum random
Schrödinger operators with applications to Anderson orthogonality and the spectral
shift function,” Journal of Spectral Theory, vol. 9, no. 3. European Mathematical
Society Publishing House, pp. 921–965, 2019.
ista: Dietlein AM, Gebert M, Müller P. 2019. Perturbations of continuum random Schrödinger
operators with applications to Anderson orthogonality and the spectral shift function.
Journal of Spectral Theory. 9(3), 921–965.
mla: Dietlein, Adrian M., et al. “Perturbations of Continuum Random Schrödinger
Operators with Applications to Anderson Orthogonality and the Spectral Shift Function.”
Journal of Spectral Theory, vol. 9, no. 3, European Mathematical Society
Publishing House, 2019, pp. 921–65, doi:10.4171/jst/267.
short: A.M. Dietlein, M. Gebert, P. Müller, Journal of Spectral Theory 9 (2019)
921–965.
date_created: 2022-03-18T12:36:42Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2023-09-08T11:35:31Z
day: '01'
department:
- _id: LaEr
doi: 10.4171/jst/267
external_id:
arxiv:
- '1701.02956'
isi:
- '000484709400006'
intvolume: ' 9'
isi: 1
issue: '3'
keyword:
- Random Schrödinger operators
- spectral shift function
- Anderson orthogonality
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1701.02956
month: '03'
oa: 1
oa_version: Preprint
page: 921-965
publication: Journal of Spectral Theory
publication_identifier:
issn:
- 1664-039X
publication_status: published
publisher: European Mathematical Society Publishing House
quality_controlled: '1'
scopus_import: '1'
status: public
title: Perturbations of continuum random Schrödinger operators with applications to
Anderson orthogonality and the spectral shift function
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 9
year: '2019'
...
---
_id: '10878'
abstract:
- lang: eng
text: Starting from a microscopic model for a system of neurons evolving in time
which individually follow a stochastic integrate-and-fire type model, we study
a mean-field limit of the system. Our model is described by a system of SDEs with
discontinuous coefficients for the action potential of each neuron and takes into
account the (random) spatial configuration of neurons allowing the interaction
to depend on it. In the limit as the number of particles tends to infinity, we
obtain a nonlinear Fokker-Planck type PDE in two variables, with derivatives only
with respect to one variable and discontinuous coefficients. We also study strong
well-posedness of the system of SDEs and prove the existence and uniqueness of
a weak measure-valued solution to the PDE, obtained as the limit of the laws of
the empirical measures for the system of particles.
acknowledgement: "The second author has been partially supported by INdAM through
the GNAMPA Research\r\nProject (2017) “Sistemi stocastici singolari: buona posizione
e problemi di controllo”. The third\r\nauthor was partly funded by the Austrian
Science Fund (FWF) project F 65."
article_processing_charge: No
article_type: original
author:
- first_name: Franco
full_name: Flandoli, Franco
last_name: Flandoli
- first_name: Enrico
full_name: Priola, Enrico
last_name: Priola
- first_name: Giovanni A
full_name: Zanco, Giovanni A
id: 47491882-F248-11E8-B48F-1D18A9856A87
last_name: Zanco
citation:
ama: Flandoli F, Priola E, Zanco GA. A mean-field model with discontinuous coefficients
for neurons with spatial interaction. Discrete and Continuous Dynamical Systems.
2019;39(6):3037-3067. doi:10.3934/dcds.2019126
apa: Flandoli, F., Priola, E., & Zanco, G. A. (2019). A mean-field model with
discontinuous coefficients for neurons with spatial interaction. Discrete and
Continuous Dynamical Systems. American Institute of Mathematical Sciences.
https://doi.org/10.3934/dcds.2019126
chicago: Flandoli, Franco, Enrico Priola, and Giovanni A Zanco. “A Mean-Field Model
with Discontinuous Coefficients for Neurons with Spatial Interaction.” Discrete
and Continuous Dynamical Systems. American Institute of Mathematical Sciences,
2019. https://doi.org/10.3934/dcds.2019126.
ieee: F. Flandoli, E. Priola, and G. A. Zanco, “A mean-field model with discontinuous
coefficients for neurons with spatial interaction,” Discrete and Continuous
Dynamical Systems, vol. 39, no. 6. American Institute of Mathematical Sciences,
pp. 3037–3067, 2019.
ista: Flandoli F, Priola E, Zanco GA. 2019. A mean-field model with discontinuous
coefficients for neurons with spatial interaction. Discrete and Continuous Dynamical
Systems. 39(6), 3037–3067.
mla: Flandoli, Franco, et al. “A Mean-Field Model with Discontinuous Coefficients
for Neurons with Spatial Interaction.” Discrete and Continuous Dynamical Systems,
vol. 39, no. 6, American Institute of Mathematical Sciences, 2019, pp. 3037–67,
doi:10.3934/dcds.2019126.
short: F. Flandoli, E. Priola, G.A. Zanco, Discrete and Continuous Dynamical Systems
39 (2019) 3037–3067.
date_created: 2022-03-18T12:33:34Z
date_published: 2019-06-01T00:00:00Z
date_updated: 2023-09-08T11:34:45Z
day: '01'
department:
- _id: JaMa
doi: 10.3934/dcds.2019126
external_id:
arxiv:
- '1708.04156'
isi:
- '000459954800003'
intvolume: ' 39'
isi: 1
issue: '6'
keyword:
- Applied Mathematics
- Discrete Mathematics and Combinatorics
- Analysis
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1708.04156
month: '06'
oa: 1
oa_version: Preprint
page: 3037-3067
project:
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
grant_number: F6504
name: Taming Complexity in Partial Differential Systems
publication: Discrete and Continuous Dynamical Systems
publication_identifier:
issn:
- 1553-5231
publication_status: published
publisher: American Institute of Mathematical Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: A mean-field model with discontinuous coefficients for neurons with spatial
interaction
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 39
year: '2019'
...
---
_id: '6935'
abstract:
- lang: eng
text: "This paper investigates the power of preprocessing in the CONGEST model.
Schmid and Suomela (ACM HotSDN 2013) introduced the SUPPORTED CONGEST model to
study the application of distributed algorithms in Software-Defined Networks (SDNs).
In this paper, we show that a large class of lower bounds in the CONGEST model
still hold in the SUPPORTED model, highlighting the robustness of these bounds.
This also raises the question how much does\r\npreprocessing help in the CONGEST
model."
article_processing_charge: No
author:
- first_name: Klaus-Tycho
full_name: Foerster, Klaus-Tycho
last_name: Foerster
- first_name: Janne
full_name: Korhonen, Janne
id: C5402D42-15BC-11E9-A202-CA2BE6697425
last_name: Korhonen
- first_name: Joel
full_name: Rybicki, Joel
id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
last_name: Rybicki
orcid: 0000-0002-6432-6646
- first_name: Stefan
full_name: Schmid, Stefan
last_name: Schmid
citation:
ama: 'Foerster K-T, Korhonen J, Rybicki J, Schmid S. Does preprocessing help under
congestion? In: Proceedings of the 2019 ACM Symposium on Principles of Distributed
Computing. ACM; 2019:259-261. doi:10.1145/3293611.3331581'
apa: 'Foerster, K.-T., Korhonen, J., Rybicki, J., & Schmid, S. (2019). Does
preprocessing help under congestion? In Proceedings of the 2019 ACM Symposium
on Principles of Distributed Computing (pp. 259–261). Toronto, ON, Canada:
ACM. https://doi.org/10.1145/3293611.3331581'
chicago: Foerster, Klaus-Tycho, Janne Korhonen, Joel Rybicki, and Stefan Schmid.
“Does Preprocessing Help under Congestion?” In Proceedings of the 2019 ACM
Symposium on Principles of Distributed Computing, 259–61. ACM, 2019. https://doi.org/10.1145/3293611.3331581.
ieee: K.-T. Foerster, J. Korhonen, J. Rybicki, and S. Schmid, “Does preprocessing
help under congestion?,” in Proceedings of the 2019 ACM Symposium on Principles
of Distributed Computing, Toronto, ON, Canada, 2019, pp. 259–261.
ista: 'Foerster K-T, Korhonen J, Rybicki J, Schmid S. 2019. Does preprocessing help
under congestion? Proceedings of the 2019 ACM Symposium on Principles of Distributed
Computing. PODC: Symposium on Principles of Distributed Computing, 259–261.'
mla: Foerster, Klaus-Tycho, et al. “Does Preprocessing Help under Congestion?” Proceedings
of the 2019 ACM Symposium on Principles of Distributed Computing, ACM, 2019,
pp. 259–61, doi:10.1145/3293611.3331581.
short: K.-T. Foerster, J. Korhonen, J. Rybicki, S. Schmid, in:, Proceedings of the
2019 ACM Symposium on Principles of Distributed Computing, ACM, 2019, pp. 259–261.
conference:
end_date: 2019-08-02
location: Toronto, ON, Canada
name: 'PODC: Symposium on Principles of Distributed Computing'
start_date: 2019-07-29
date_created: 2019-10-08T12:57:14Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2023-09-08T11:37:22Z
day: '01'
department:
- _id: DaAl
doi: 10.1145/3293611.3331581
ec_funded: 1
external_id:
arxiv:
- '1905.03012'
isi:
- '000570442000037'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.03012
month: '08'
oa: 1
oa_version: Preprint
page: 259-261
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Proceedings of the 2019 ACM Symposium on Principles of Distributed Computing
publication_identifier:
isbn:
- '9781450362177'
publication_status: published
publisher: ACM
quality_controlled: '1'
scopus_import: '1'
status: public
title: Does preprocessing help under congestion?
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '138'
abstract:
- lang: eng
text: Autoregulation is the direct modulation of gene expression by the product
of the corresponding gene. Autoregulation of bacterial gene expression has been
mostly studied at the transcriptional level, when a protein acts as the cognate
transcriptional repressor. A recent study investigating dynamics of the bacterial
toxin–antitoxin MazEF system has shown how autoregulation at both the transcriptional
and post-transcriptional levels affects the heterogeneity of Escherichia coli
populations. Toxin–antitoxin systems hold a crucial but still elusive part in
bacterial response to stress. This perspective highlights how these modules can
also serve as a great model system for investigating basic concepts in gene regulation.
However, as the genomic background and environmental conditions substantially
influence toxin activation, it is important to study (auto)regulation of toxin–antitoxin
systems in well-defined setups as well as in conditions that resemble the environmental
niche.
article_processing_charge: Yes (via OA deal)
author:
- first_name: Nela
full_name: Nikolic, Nela
id: 42D9CABC-F248-11E8-B48F-1D18A9856A87
last_name: Nikolic
orcid: 0000-0001-9068-6090
citation:
ama: 'Nikolic N. Autoregulation of bacterial gene expression: lessons from the MazEF
toxin–antitoxin system. Current Genetics. 2019;65(1):133-138. doi:10.1007/s00294-018-0879-8'
apa: 'Nikolic, N. (2019). Autoregulation of bacterial gene expression: lessons from
the MazEF toxin–antitoxin system. Current Genetics. Springer. https://doi.org/10.1007/s00294-018-0879-8'
chicago: 'Nikolic, Nela. “Autoregulation of Bacterial Gene Expression: Lessons from
the MazEF Toxin–Antitoxin System.” Current Genetics. Springer, 2019. https://doi.org/10.1007/s00294-018-0879-8.'
ieee: 'N. Nikolic, “Autoregulation of bacterial gene expression: lessons from the
MazEF toxin–antitoxin system,” Current Genetics, vol. 65, no. 1. Springer,
pp. 133–138, 2019.'
ista: 'Nikolic N. 2019. Autoregulation of bacterial gene expression: lessons from
the MazEF toxin–antitoxin system. Current Genetics. 65(1), 133–138.'
mla: 'Nikolic, Nela. “Autoregulation of Bacterial Gene Expression: Lessons from
the MazEF Toxin–Antitoxin System.” Current Genetics, vol. 65, no. 1, Springer,
2019, pp. 133–38, doi:10.1007/s00294-018-0879-8.'
short: N. Nikolic, Current Genetics 65 (2019) 133–138.
date_created: 2018-12-11T11:44:50Z
date_published: 2019-02-01T00:00:00Z
date_updated: 2023-09-08T13:23:42Z
day: '01'
ddc:
- '570'
department:
- _id: CaGu
doi: 10.1007/s00294-018-0879-8
ec_funded: 1
external_id:
isi:
- '000456958800017'
file:
- access_level: open_access
checksum: 6779708b0b632a1a6ed28c56f5161142
content_type: application/pdf
creator: dernst
date_created: 2019-02-06T07:50:58Z
date_updated: 2020-07-14T12:44:47Z
file_id: '5930'
file_name: 2019_CurrentGenetics_Nikolic.pdf
file_size: 776399
relation: main_file
file_date_updated: 2020-07-14T12:44:47Z
has_accepted_license: '1'
intvolume: ' 65'
isi: 1
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 133-138
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Current Genetics
publication_status: published
publisher: Springer
publist_id: '7785'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin
system'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 65
year: '2019'
...