---
_id: '324'
abstract:
- lang: eng
text: Neuronal networks in the brain consist of two main types of neuron, glutamatergic
principal neurons and GABAergic interneurons. Although these interneurons only
represent 10–20% of the whole population, they mediate feedback and feedforward
inhibition and are involved in the generation of high-frequency network oscillations.
A hallmark functional property of GABAergic interneurons, especially of the parvalbumin‑expressing
(PV+) subtypes, is the speed of signaling at their output synapse across species
and brain regions. Several molecular and subcellular factors may underlie the
submillisecond signaling at GABAergic synapses. Such as the selective use of P/Q
type Ca2+ channels and the tight coupling between Ca2+ channels and Ca2+ sensors
of exocytosis. However, whether the molecular identity of the release sensor contributes
to these signaling properties remains unclear. Besides, these interneurons are
mainly show depression in response to train of stimuli. How could they keep sufficient
release to control the activity of postsynaptic principal neurons during high
network activity, is largely elusive. For my Ph.D. work, we firstly examined the
Ca2+ sensor of exocytosis at the GABAergic basket cell (BC) to Purkinje cell (PC)
synapse in the cerebellum. Immunolabeling suggested that BC terminals selectively
expressed synaptotagmin 2 (Syt2), whereas synaptotagmin 1 (Syt1) was enriched
in excitatory terminals. Genetic elimination of Syt2 reduced action potential-evoked
release to ~10% compared to the wild-type control, identifying Syt2 as the major
Ca2+ sensor at BC‑PC synapses. Differential adenovirus-mediated rescue revealed
Syt2 triggered release with shorter latency and higher temporal precision, and
mediated faster vesicle pool replenishment than Syt1. Furthermore, deletion of
Syt2 severely reduced and delayed disynaptic inhibition following parallel fiber
stimulation. Thus, the selective use of Syt2 as the release sensor at BC–PC synapse
ensures fast feedforward inhibition in cerebellar microcircuits. Additionally,
we tested the function of another synaptotagmin member, Syt7, for inhibitory synaptic
transmission at the BC–PC synapse. Syt7 is thought to be a Ca2+ sensor that mediates
asynchronous transmitter release and facilitation at synapses. However, it is
strongly expressed in fast-spiking, PV+ GABAergic interneurons and the output
synapses of these neurons produce only minimal asynchronous release and show depression
rather than facilitation. How could Syt7, a facilitation sensor, contribute to
the depressed inhibitory synaptic transmission needs to be further investigated
and understood. Our results indicated that at the BC–PC synapse, Syt7 contributes
to asynchronous release, pool replenishment and facilitation. In combination,
these three effects ensure efficient transmitter release during high‑frequency
activity and guarantee frequency independence of inhibition. Taken together, our
results confirmed that Syt2, which has the fastest kinetic properties among all
synaptotagmin members, is mainly used by the inhibitory BC‑PC synapse for synaptic
transmission, contributing to the speed and temporal precision of transmitter
release. Furthermore, we showed that Syt7, another highly expressed synaptotagmin
member in the output synapses of cerebellar BCs, is used for ensuring efficient
inhibitor synaptic transmission during high activity.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Chong
full_name: Chen, Chong
id: 3DFD581A-F248-11E8-B48F-1D18A9856A87
last_name: Chen
citation:
ama: Chen C. Synaptotagmins ensure speed and efficiency of inhibitory neurotransmitter
release. 2018. doi:10.15479/AT:ISTA:th_997
apa: Chen, C. (2018). Synaptotagmins ensure speed and efficiency of inhibitory
neurotransmitter release. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:th_997
chicago: Chen, Chong. “Synaptotagmins Ensure Speed and Efficiency of Inhibitory
Neurotransmitter Release.” Institute of Science and Technology Austria, 2018.
https://doi.org/10.15479/AT:ISTA:th_997.
ieee: C. Chen, “Synaptotagmins ensure speed and efficiency of inhibitory neurotransmitter
release,” Institute of Science and Technology Austria, 2018.
ista: Chen C. 2018. Synaptotagmins ensure speed and efficiency of inhibitory neurotransmitter
release. Institute of Science and Technology Austria.
mla: Chen, Chong. Synaptotagmins Ensure Speed and Efficiency of Inhibitory Neurotransmitter
Release. Institute of Science and Technology Austria, 2018, doi:10.15479/AT:ISTA:th_997.
short: C. Chen, Synaptotagmins Ensure Speed and Efficiency of Inhibitory Neurotransmitter
Release, Institute of Science and Technology Austria, 2018.
date_created: 2018-12-11T11:45:49Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2023-09-27T12:26:03Z
day: '01'
ddc:
- '571'
degree_awarded: PhD
department:
- _id: PeJo
doi: 10.15479/AT:ISTA:th_997
file:
- access_level: open_access
checksum: 8e163ae9e927401b9fa7c1b3e6a3631a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:58Z
date_updated: 2020-07-14T12:46:04Z
file_id: '5046'
file_name: IST-2018-997-v1+1_Thesis_chong_a.pdf
file_size: 8719458
relation: main_file
- access_level: closed
checksum: f7d7260029a5fbb5c982db61328ade52
content_type: application/octet-stream
creator: dernst
date_created: 2019-04-05T09:25:26Z
date_updated: 2020-07-14T12:46:04Z
file_id: '6221'
file_name: 2018_Thesis_chong_source.pages
file_size: 47841940
relation: source_file
file_date_updated: 2020-07-14T12:46:04Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: '110'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '7541'
pubrep_id: '997'
related_material:
record:
- id: '1117'
relation: part_of_dissertation
status: public
- id: '749'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
title: Synaptotagmins ensure speed and efficiency of inhibitory neurotransmitter release
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '742'
abstract:
- lang: eng
text: 'We give a detailed and easily accessible proof of Gromov’s Topological Overlap
Theorem. Let X be a finite simplicial complex or, more generally, a finite polyhedral
cell complex of dimension d. Informally, the theorem states that if X has sufficiently
strong higher-dimensional expansion properties (which generalize edge expansion
of graphs and are defined in terms of cellular cochains of X) then X has the following
topological overlap property: for every continuous map (Formula presented.) there
exists a point (Formula presented.) that is contained in the images of a positive
fraction (Formula presented.) of the d-cells of X. More generally, the conclusion
holds if (Formula presented.) is replaced by any d-dimensional piecewise-linear
manifold M, with a constant (Formula presented.) that depends only on d and on
the expansion properties of X, but not on M.'
article_processing_charge: Yes (via OA deal)
author:
- first_name: Dominic
full_name: Dotterrer, Dominic
last_name: Dotterrer
- first_name: Tali
full_name: Kaufman, Tali
last_name: Kaufman
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: Dotterrer D, Kaufman T, Wagner U. On expansion and topological overlap. Geometriae
Dedicata. 2018;195(1):307–317. doi:10.1007/s10711-017-0291-4
apa: Dotterrer, D., Kaufman, T., & Wagner, U. (2018). On expansion and topological
overlap. Geometriae Dedicata. Springer. https://doi.org/10.1007/s10711-017-0291-4
chicago: Dotterrer, Dominic, Tali Kaufman, and Uli Wagner. “On Expansion and Topological
Overlap.” Geometriae Dedicata. Springer, 2018. https://doi.org/10.1007/s10711-017-0291-4.
ieee: D. Dotterrer, T. Kaufman, and U. Wagner, “On expansion and topological overlap,”
Geometriae Dedicata, vol. 195, no. 1. Springer, pp. 307–317, 2018.
ista: Dotterrer D, Kaufman T, Wagner U. 2018. On expansion and topological overlap.
Geometriae Dedicata. 195(1), 307–317.
mla: Dotterrer, Dominic, et al. “On Expansion and Topological Overlap.” Geometriae
Dedicata, vol. 195, no. 1, Springer, 2018, pp. 307–317, doi:10.1007/s10711-017-0291-4.
short: D. Dotterrer, T. Kaufman, U. Wagner, Geometriae Dedicata 195 (2018) 307–317.
date_created: 2018-12-11T11:48:16Z
date_published: 2018-08-01T00:00:00Z
date_updated: 2023-09-27T12:29:57Z
day: '01'
ddc:
- '514'
- '516'
department:
- _id: UlWa
doi: 10.1007/s10711-017-0291-4
external_id:
isi:
- '000437122700017'
file:
- access_level: open_access
checksum: d2f70fc132156504aa4c626aa378a7ab
content_type: application/pdf
creator: kschuh
date_created: 2019-01-15T13:44:05Z
date_updated: 2020-07-14T12:47:58Z
file_id: '5835'
file_name: s10711-017-0291-4.pdf
file_size: 412486
relation: main_file
file_date_updated: 2020-07-14T12:47:58Z
has_accepted_license: '1'
intvolume: ' 195'
isi: 1
issue: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 307–317
project:
- _id: 25FA3206-B435-11E9-9278-68D0E5697425
grant_number: PP00P2_138948
name: 'Embeddings in Higher Dimensions: Algorithms and Combinatorics'
publication: Geometriae Dedicata
publication_status: published
publisher: Springer
publist_id: '6925'
pubrep_id: '912'
quality_controlled: '1'
related_material:
record:
- id: '1378'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: On expansion and topological overlap
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 195
year: '2018'
...
---
_id: '70'
abstract:
- lang: eng
text: We consider the totally asymmetric simple exclusion process in a critical
scaling parametrized by a≥0, which creates a shock in the particle density of
order aT−1/3, T the observation time. When starting from step initial data, we
provide bounds on the limiting law which in particular imply that in the double
limit lima→∞limT→∞ one recovers the product limit law and the degeneration of
the correlation length observed at shocks of order 1. This result is shown to
apply to a general last-passage percolation model. We also obtain bounds on the
two-point functions of several airy processes.
article_processing_charge: No
article_type: original
author:
- first_name: Peter
full_name: Nejjar, Peter
id: 4BF426E2-F248-11E8-B48F-1D18A9856A87
last_name: Nejjar
citation:
ama: Nejjar P. Transition to shocks in TASEP and decoupling of last passage times.
Latin American Journal of Probability and Mathematical Statistics. 2018;15(2):1311-1334.
doi:10.30757/ALEA.v15-49
apa: Nejjar, P. (2018). Transition to shocks in TASEP and decoupling of last passage
times. Latin American Journal of Probability and Mathematical Statistics.
Instituto Nacional de Matematica Pura e Aplicada. https://doi.org/10.30757/ALEA.v15-49
chicago: Nejjar, Peter. “Transition to Shocks in TASEP and Decoupling of Last Passage
Times.” Latin American Journal of Probability and Mathematical Statistics.
Instituto Nacional de Matematica Pura e Aplicada, 2018. https://doi.org/10.30757/ALEA.v15-49.
ieee: P. Nejjar, “Transition to shocks in TASEP and decoupling of last passage times,”
Latin American Journal of Probability and Mathematical Statistics, vol.
15, no. 2. Instituto Nacional de Matematica Pura e Aplicada, pp. 1311–1334, 2018.
ista: Nejjar P. 2018. Transition to shocks in TASEP and decoupling of last passage
times. Latin American Journal of Probability and Mathematical Statistics. 15(2),
1311–1334.
mla: Nejjar, Peter. “Transition to Shocks in TASEP and Decoupling of Last Passage
Times.” Latin American Journal of Probability and Mathematical Statistics,
vol. 15, no. 2, Instituto Nacional de Matematica Pura e Aplicada, 2018, pp. 1311–34,
doi:10.30757/ALEA.v15-49.
short: P. Nejjar, Latin American Journal of Probability and Mathematical Statistics
15 (2018) 1311–1334.
date_created: 2018-12-11T11:44:28Z
date_published: 2018-10-01T00:00:00Z
date_updated: 2023-10-10T13:11:29Z
day: '01'
ddc:
- '510'
department:
- _id: LaEr
- _id: JaMa
doi: 10.30757/ALEA.v15-49
ec_funded: 1
external_id:
arxiv:
- '1705.08836'
isi:
- '000460475800022'
file:
- access_level: open_access
checksum: 2ded46aa284a836a8cbb34133a64f1cb
content_type: application/pdf
creator: kschuh
date_created: 2019-02-14T09:44:10Z
date_updated: 2020-07-14T12:47:46Z
file_id: '5981'
file_name: 2018_ALEA_Nejjar.pdf
file_size: 394851
relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: ' 15'
isi: 1
issue: '2'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 1311-1334
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
publication: Latin American Journal of Probability and Mathematical Statistics
publication_identifier:
issn:
- 1980-0436
publication_status: published
publisher: Instituto Nacional de Matematica Pura e Aplicada
quality_controlled: '1'
scopus_import: '1'
status: public
title: Transition to shocks in TASEP and decoupling of last passage times
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2018'
...
---
_id: '44'
abstract:
- lang: eng
text: 'Recent realization of a kinetically constrained chain of Rydberg atoms by
Bernien et al., [Nature (London) 551, 579 (2017)] resulted in the observation
of unusual revivals in the many-body quantum dynamics. In our previous work [C.
J. Turner et al., Nat. Phys. 14, 745 (2018)], such dynamics was attributed to
the existence of “quantum scarred” eigenstates in the many-body spectrum of the
experimentally realized model. Here, we present a detailed study of the eigenstate
properties of the same model. We find that the majority of the eigenstates exhibit
anomalous thermalization: the observable expectation values converge to their
Gibbs ensemble values, but parametrically slower compared to the predictions of
the eigenstate thermalization hypothesis (ETH). Amidst the thermalizing spectrum,
we identify nonergodic eigenstates that strongly violate the ETH, whose number
grows polynomially with system size. Previously, the same eigenstates were identified
via large overlaps with certain product states, and were used to explain the revivals
observed in experiment. Here, we find that these eigenstates, in addition to highly
atypical expectation values of local observables, also exhibit subthermal entanglement
entropy that scales logarithmically with the system size. Moreover, we identify
an additional class of quantum scarred eigenstates, and discuss their manifestations
in the dynamics starting from initial product states. We use forward scattering
approximation to describe the structure and physical properties of quantum scarred
eigenstates. Finally, we discuss the stability of quantum scars to various perturbations.
We observe that quantum scars remain robust when the introduced perturbation is
compatible with the forward scattering approximation. In contrast, the perturbations
which most efficiently destroy quantum scars also lead to the restoration of “canonical”
thermalization.'
acknowledged_ssus:
- _id: ScienComp
article_number: '155134'
article_processing_charge: No
author:
- first_name: C J
full_name: Turner, C J
last_name: Turner
- first_name: Alexios
full_name: Michailidis, Alexios
id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
last_name: Michailidis
orcid: 0000-0002-8443-1064
- first_name: D A
full_name: Abanin, D A
last_name: Abanin
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Z
full_name: Papić, Z
last_name: Papić
citation:
ama: 'Turner CJ, Michailidis A, Abanin DA, Serbyn M, Papić Z. Quantum scarred eigenstates
in a Rydberg atom chain: Entanglement, breakdown of thermalization, and stability
to perturbations. Physical Review B. 2018;98(15). doi:10.1103/PhysRevB.98.155134'
apa: 'Turner, C. J., Michailidis, A., Abanin, D. A., Serbyn, M., & Papić, Z.
(2018). Quantum scarred eigenstates in a Rydberg atom chain: Entanglement, breakdown
of thermalization, and stability to perturbations. Physical Review B. American
Physical Society. https://doi.org/10.1103/PhysRevB.98.155134'
chicago: 'Turner, C J, Alexios Michailidis, D A Abanin, Maksym Serbyn, and Z Papić.
“Quantum Scarred Eigenstates in a Rydberg Atom Chain: Entanglement, Breakdown
of Thermalization, and Stability to Perturbations.” Physical Review B.
American Physical Society, 2018. https://doi.org/10.1103/PhysRevB.98.155134.'
ieee: 'C. J. Turner, A. Michailidis, D. A. Abanin, M. Serbyn, and Z. Papić, “Quantum
scarred eigenstates in a Rydberg atom chain: Entanglement, breakdown of thermalization,
and stability to perturbations,” Physical Review B, vol. 98, no. 15. American
Physical Society, 2018.'
ista: 'Turner CJ, Michailidis A, Abanin DA, Serbyn M, Papić Z. 2018. Quantum scarred
eigenstates in a Rydberg atom chain: Entanglement, breakdown of thermalization,
and stability to perturbations. Physical Review B. 98(15), 155134.'
mla: 'Turner, C. J., et al. “Quantum Scarred Eigenstates in a Rydberg Atom Chain:
Entanglement, Breakdown of Thermalization, and Stability to Perturbations.” Physical
Review B, vol. 98, no. 15, 155134, American Physical Society, 2018, doi:10.1103/PhysRevB.98.155134.'
short: C.J. Turner, A. Michailidis, D.A. Abanin, M. Serbyn, Z. Papić, Physical Review
B 98 (2018).
date_created: 2018-12-11T11:44:19Z
date_published: 2018-10-22T00:00:00Z
date_updated: 2023-10-10T13:28:49Z
day: '22'
department:
- _id: MaSe
doi: 10.1103/PhysRevB.98.155134
external_id:
arxiv:
- '1806.10933'
isi:
- '000447919100001'
intvolume: ' 98'
isi: 1
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1806.10933
month: '10'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_status: published
publisher: American Physical Society
publist_id: '8010'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Quantum scarred eigenstates in a Rydberg atom chain: Entanglement, breakdown
of thermalization, and stability to perturbations'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 98
year: '2018'
...
---
_id: '328'
abstract:
- lang: eng
text: The drag of turbulent flows can be drastically decreased by adding small amounts
of high molecular weight polymers. While drag reduction initially increases with
polymer concentration, it eventually saturates to what is known as the maximum
drag reduction (MDR) asymptote; this asymptote is generally attributed to the
dynamics being reduced to a marginal yet persistent state of subdued turbulent
motion. Contrary to this accepted view, we show that, for an appropriate choice
of parameters, polymers can reduce the drag beyond the suggested asymptotic limit,
eliminating turbulence and giving way to laminar flow. At higher polymer concentrations,
however, the laminar state becomes unstable, resulting in a fluctuating flow with
the characteristic drag of the MDR asymptote. Our findings indicate that the asymptotic
state is hence dynamically disconnected from ordinary turbulence. © 2018 American
Physical Society.
acknowledged_ssus:
- _id: SSU
acknowledgement: The authors thank Philipp Maier and the IST Austria workshop for
their dedicated technical support.
article_number: '124501'
article_processing_charge: No
author:
- first_name: George H
full_name: Choueiri, George H
id: 448BD5BC-F248-11E8-B48F-1D18A9856A87
last_name: Choueiri
- first_name: Jose M
full_name: Lopez Alonso, Jose M
id: 40770848-F248-11E8-B48F-1D18A9856A87
last_name: Lopez Alonso
orcid: 0000-0002-0384-2022
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Choueiri GH, Lopez Alonso JM, Hof B. Exceeding the asymptotic limit of polymer
drag reduction. Physical Review Letters. 2018;120(12). doi:10.1103/PhysRevLett.120.124501
apa: Choueiri, G. H., Lopez Alonso, J. M., & Hof, B. (2018). Exceeding the asymptotic
limit of polymer drag reduction. Physical Review Letters. American Physical
Society. https://doi.org/10.1103/PhysRevLett.120.124501
chicago: Choueiri, George H, Jose M Lopez Alonso, and Björn Hof. “Exceeding the
Asymptotic Limit of Polymer Drag Reduction.” Physical Review Letters. American
Physical Society, 2018. https://doi.org/10.1103/PhysRevLett.120.124501.
ieee: G. H. Choueiri, J. M. Lopez Alonso, and B. Hof, “Exceeding the asymptotic
limit of polymer drag reduction,” Physical Review Letters, vol. 120, no.
12. American Physical Society, 2018.
ista: Choueiri GH, Lopez Alonso JM, Hof B. 2018. Exceeding the asymptotic limit
of polymer drag reduction. Physical Review Letters. 120(12), 124501.
mla: Choueiri, George H., et al. “Exceeding the Asymptotic Limit of Polymer Drag
Reduction.” Physical Review Letters, vol. 120, no. 12, 124501, American
Physical Society, 2018, doi:10.1103/PhysRevLett.120.124501.
short: G.H. Choueiri, J.M. Lopez Alonso, B. Hof, Physical Review Letters 120 (2018).
date_created: 2018-12-11T11:45:51Z
date_published: 2018-03-19T00:00:00Z
date_updated: 2023-10-10T13:27:44Z
day: '19'
department:
- _id: BjHo
doi: 10.1103/PhysRevLett.120.124501
ec_funded: 1
external_id:
isi:
- '000427804000005'
intvolume: ' 120'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1703.06271
month: '03'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '306589'
name: Decoding the complexity of turbulence at its origin
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '7537'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Exceeding the asymptotic limit of polymer drag reduction
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 120
year: '2018'
...
---
_id: '136'
abstract:
- lang: eng
text: Recent studies suggest that unstable, nonchaotic solutions of the Navier-Stokes
equation may provide deep insights into fluid turbulence. In this article, we
present a combined experimental and numerical study exploring the dynamical role
of unstable equilibrium solutions and their invariant manifolds in a weakly turbulent,
electromagnetically driven, shallow fluid layer. Identifying instants when turbulent
evolution slows down, we compute 31 unstable equilibria of a realistic two-dimensional
model of the flow. We establish the dynamical relevance of these unstable equilibria
by showing that they are closely visited by the turbulent flow. We also establish
the dynamical relevance of unstable manifolds by verifying that they are shadowed
by turbulent trajectories departing from the neighborhoods of unstable equilibria
over large distances in state space.
article_processing_charge: No
author:
- first_name: Balachandra
full_name: Suri, Balachandra
id: 47A5E706-F248-11E8-B48F-1D18A9856A87
last_name: Suri
- first_name: Jeffrey
full_name: Tithof, Jeffrey
last_name: Tithof
- first_name: Roman
full_name: Grigoriev, Roman
last_name: Grigoriev
- first_name: Michael
full_name: Schatz, Michael
last_name: Schatz
citation:
ama: Suri B, Tithof J, Grigoriev R, Schatz M. Unstable equilibria and invariant
manifolds in quasi-two-dimensional Kolmogorov-like flow. Physical Review E.
2018;98(2). doi:10.1103/PhysRevE.98.023105
apa: Suri, B., Tithof, J., Grigoriev, R., & Schatz, M. (2018). Unstable equilibria
and invariant manifolds in quasi-two-dimensional Kolmogorov-like flow. Physical
Review E. American Physical Society. https://doi.org/10.1103/PhysRevE.98.023105
chicago: Suri, Balachandra, Jeffrey Tithof, Roman Grigoriev, and Michael Schatz.
“Unstable Equilibria and Invariant Manifolds in Quasi-Two-Dimensional Kolmogorov-like
Flow.” Physical Review E. American Physical Society, 2018. https://doi.org/10.1103/PhysRevE.98.023105.
ieee: B. Suri, J. Tithof, R. Grigoriev, and M. Schatz, “Unstable equilibria and
invariant manifolds in quasi-two-dimensional Kolmogorov-like flow,” Physical
Review E, vol. 98, no. 2. American Physical Society, 2018.
ista: Suri B, Tithof J, Grigoriev R, Schatz M. 2018. Unstable equilibria and invariant
manifolds in quasi-two-dimensional Kolmogorov-like flow. Physical Review E. 98(2).
mla: Suri, Balachandra, et al. “Unstable Equilibria and Invariant Manifolds in Quasi-Two-Dimensional
Kolmogorov-like Flow.” Physical Review E, vol. 98, no. 2, American Physical
Society, 2018, doi:10.1103/PhysRevE.98.023105.
short: B. Suri, J. Tithof, R. Grigoriev, M. Schatz, Physical Review E 98 (2018).
date_created: 2018-12-11T11:44:49Z
date_published: 2018-08-13T00:00:00Z
date_updated: 2023-10-10T13:29:10Z
day: '13'
department:
- _id: BjHo
doi: 10.1103/PhysRevE.98.023105
external_id:
arxiv:
- '1808.02088'
isi:
- '000441466800010'
intvolume: ' 98'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1808.02088
month: '08'
oa: 1
oa_version: Submitted Version
publication: Physical Review E
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unstable equilibria and invariant manifolds in quasi-two-dimensional Kolmogorov-like
flow
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 98
year: '2018'
...
---
_id: '691'
abstract:
- lang: eng
text: "Background: Transport protein particle (TRAPP) is a multisubunit complex
that regulates membrane trafficking through the Golgi apparatus. The clinical
phenotype associated with mutations in various TRAPP subunits has allowed elucidation
of their functions in specific tissues. The role of some subunits in human disease,
however, has not been fully established, and their functions remain uncertain.\r\n\r\nObjective:
We aimed to expand the range of neurodevelopmental disorders associated with mutations
in TRAPP subunits by exome sequencing of consanguineous families.\r\n\r\nMethods:
Linkage and homozygosity mapping and candidate gene analysis were used to identify
homozygous mutations in families. Patient fibroblasts were used to study splicing
defect and zebrafish to model the disease.\r\n\r\nResults: We identified six individuals
from three unrelated families with a founder homozygous splice mutation in TRAPPC6B,
encoding a core subunit of the complex TRAPP I. Patients manifested a neurodevelopmental
disorder characterised by microcephaly, epilepsy and autistic features, and showed
splicing defect. Zebrafish trappc6b morphants replicated the human phenotype,
displaying decreased head size and neuronal hyperexcitability, leading to a lower
seizure threshold.\r\n\r\nConclusion: This study provides clinical and functional
evidence of the role of TRAPPC6B in brain development and function."
article_processing_charge: No
article_type: original
author:
- first_name: Isaac
full_name: Marin Valencia, Isaac
last_name: Marin Valencia
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Anide
full_name: Johansen, Anide
last_name: Johansen
- first_name: Başak
full_name: Rosti, Başak
last_name: Rosti
- first_name: Mahmoud
full_name: Issa, Mahmoud
last_name: Issa
- first_name: Damir
full_name: Musaev, Damir
last_name: Musaev
- first_name: Gifty
full_name: Bhat, Gifty
last_name: Bhat
- first_name: Eric
full_name: Scott, Eric
last_name: Scott
- first_name: Jennifer
full_name: Silhavy, Jennifer
last_name: Silhavy
- first_name: Valentina
full_name: Stanley, Valentina
last_name: Stanley
- first_name: Rasim
full_name: Rosti, Rasim
last_name: Rosti
- first_name: Jeremy
full_name: Gleeson, Jeremy
last_name: Gleeson
- first_name: Farhad
full_name: Imam, Farhad
last_name: Imam
- first_name: Maha
full_name: Zaki, Maha
last_name: Zaki
- first_name: Joseph
full_name: Gleeson, Joseph
last_name: Gleeson
citation:
ama: Marin Valencia I, Novarino G, Johansen A, et al. A homozygous founder mutation
in TRAPPC6B associates with a neurodevelopmental disorder characterised by microcephaly
epilepsy and autistic features. Journal of Medical Genetics. 2018;55(1):48-54.
doi:10.1136/jmedgenet-2017-104627
apa: Marin Valencia, I., Novarino, G., Johansen, A., Rosti, B., Issa, M., Musaev,
D., … Gleeson, J. (2018). A homozygous founder mutation in TRAPPC6B associates
with a neurodevelopmental disorder characterised by microcephaly epilepsy and
autistic features. Journal of Medical Genetics. BMJ Publishing Group. https://doi.org/10.1136/jmedgenet-2017-104627
chicago: Marin Valencia, Isaac, Gaia Novarino, Anide Johansen, Başak Rosti, Mahmoud
Issa, Damir Musaev, Gifty Bhat, et al. “A Homozygous Founder Mutation in TRAPPC6B
Associates with a Neurodevelopmental Disorder Characterised by Microcephaly Epilepsy
and Autistic Features.” Journal of Medical Genetics. BMJ Publishing Group,
2018. https://doi.org/10.1136/jmedgenet-2017-104627.
ieee: I. Marin Valencia et al., “A homozygous founder mutation in TRAPPC6B
associates with a neurodevelopmental disorder characterised by microcephaly epilepsy
and autistic features,” Journal of Medical Genetics, vol. 55, no. 1. BMJ
Publishing Group, pp. 48–54, 2018.
ista: Marin Valencia I, Novarino G, Johansen A, Rosti B, Issa M, Musaev D, Bhat
G, Scott E, Silhavy J, Stanley V, Rosti R, Gleeson J, Imam F, Zaki M, Gleeson
J. 2018. A homozygous founder mutation in TRAPPC6B associates with a neurodevelopmental
disorder characterised by microcephaly epilepsy and autistic features. Journal
of Medical Genetics. 55(1), 48–54.
mla: Marin Valencia, Isaac, et al. “A Homozygous Founder Mutation in TRAPPC6B Associates
with a Neurodevelopmental Disorder Characterised by Microcephaly Epilepsy and
Autistic Features.” Journal of Medical Genetics, vol. 55, no. 1, BMJ Publishing
Group, 2018, pp. 48–54, doi:10.1136/jmedgenet-2017-104627.
short: I. Marin Valencia, G. Novarino, A. Johansen, B. Rosti, M. Issa, D. Musaev,
G. Bhat, E. Scott, J. Silhavy, V. Stanley, R. Rosti, J. Gleeson, F. Imam, M. Zaki,
J. Gleeson, Journal of Medical Genetics 55 (2018) 48–54.
date_created: 2018-12-11T11:47:57Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2023-10-16T09:55:43Z
day: '01'
department:
- _id: GaNo
doi: 10.1136/jmedgenet-2017-104627
external_id:
isi:
- '000418199800007'
pmid:
- '28626029'
intvolume: ' 55'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056005/
month: '01'
oa: 1
oa_version: Submitted Version
page: 48 - 54
pmid: 1
project:
- _id: 254BA948-B435-11E9-9278-68D0E5697425
grant_number: '401299'
name: Probing development and reversibility of autism spectrum disorders
publication: Journal of Medical Genetics
publication_identifier:
issn:
- 0022-2593
publication_status: published
publisher: BMJ Publishing Group
publist_id: '7016'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A homozygous founder mutation in TRAPPC6B associates with a neurodevelopmental
disorder characterised by microcephaly epilepsy and autistic features
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2018'
...
---
_id: '284'
abstract:
- lang: eng
text: "Borel probability measures living on metric spaces are fundamental\r\nmathematical
objects. There are several meaningful distance functions that make the collection
of the probability measures living on a certain space a metric space. We are interested
in the description of the structure of the isometries of such metric spaces. We
overview some of the recent results of the topic and we also provide some new
ones concerning the Wasserstein distance. More specifically, we consider the space
of all Borel probability measures on the unit sphere of a Euclidean space endowed
with the Wasserstein metric W_p for arbitrary p >= 1, and we show that the
action of a Wasserstein isometry on the set of Dirac measures is induced by an
isometry of the underlying unit sphere."
acknowledgement: The author was supported by the ISTFELLOW program of the Institute
of Science and Technol- ogy Austria (project code IC1027FELL01) and partially supported
by the Hungarian National Research, Development and Innovation Office, NKFIH (grant
no. K124152).
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
full_name: Virosztek, Daniel
id: 48DB45DA-F248-11E8-B48F-1D18A9856A87
last_name: Virosztek
orcid: 0000-0003-1109-5511
citation:
ama: Virosztek D. Maps on probability measures preserving certain distances - a
survey and some new results. Acta Scientiarum Mathematicarum. 2018;84(1-2):65-80.
doi:10.14232/actasm-018-753-y
apa: Virosztek, D. (2018). Maps on probability measures preserving certain distances
- a survey and some new results. Acta Scientiarum Mathematicarum. Springer
Nature. https://doi.org/10.14232/actasm-018-753-y
chicago: Virosztek, Daniel. “Maps on Probability Measures Preserving Certain Distances
- a Survey and Some New Results.” Acta Scientiarum Mathematicarum. Springer
Nature, 2018. https://doi.org/10.14232/actasm-018-753-y.
ieee: D. Virosztek, “Maps on probability measures preserving certain distances -
a survey and some new results,” Acta Scientiarum Mathematicarum, vol. 84,
no. 1–2. Springer Nature, pp. 65–80, 2018.
ista: Virosztek D. 2018. Maps on probability measures preserving certain distances
- a survey and some new results. Acta Scientiarum Mathematicarum. 84(1–2), 65–80.
mla: Virosztek, Daniel. “Maps on Probability Measures Preserving Certain Distances
- a Survey and Some New Results.” Acta Scientiarum Mathematicarum, vol.
84, no. 1–2, Springer Nature, 2018, pp. 65–80, doi:10.14232/actasm-018-753-y.
short: D. Virosztek, Acta Scientiarum Mathematicarum 84 (2018) 65–80.
date_created: 2018-12-11T11:45:36Z
date_published: 2018-06-04T00:00:00Z
date_updated: 2023-10-16T10:29:22Z
day: '04'
department:
- _id: LaEr
doi: 10.14232/actasm-018-753-y
ec_funded: 1
external_id:
arxiv:
- '1802.03305'
intvolume: ' 84'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1802.03305
month: '06'
oa: 1
oa_version: Preprint
page: 65 - 80
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Acta Scientiarum Mathematicarum
publication_identifier:
eissn:
- 2064-8316
issn:
- 0001-6969
publication_status: published
publisher: Springer Nature
publist_id: '7615'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maps on probability measures preserving certain distances - a survey and some
new results
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 84
year: '2018'
...
---
_id: '180'
abstract:
- lang: eng
text: In this paper we define and study the classical Uniform Electron Gas (UEG),
a system of infinitely many electrons whose density is constant everywhere in
space. The UEG is defined differently from Jellium, which has a positive constant
background but no constraint on the density. We prove that the UEG arises in Density
Functional Theory in the limit of a slowly varying density, minimizing the indirect
Coulomb energy. We also construct the quantum UEG and compare it to the classical
UEG at low density.
acknowledgement: "This project has received funding from the European Research Council
(ERC) under the European\r\nUnion’s Horizon 2020 research and innovation programme
(grant agreement 694227 for R.S. and MDFT 725528 for M.L.). Financial support by
the Austrian Science Fund (FWF), project No P 27533-N27 (R.S.) and by the US National
Science Foundation, grant No PHY12-1265118 (E.H.L.) are gratefully acknowledged."
article_processing_charge: No
article_type: original
author:
- first_name: Mathieu
full_name: Lewi, Mathieu
last_name: Lewi
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Lewi M, Lieb É, Seiringer R. Statistical mechanics of the uniform electron
gas. Journal de l’Ecole Polytechnique - Mathematiques. 2018;5:79-116. doi:10.5802/jep.64
apa: Lewi, M., Lieb, É., & Seiringer, R. (2018). Statistical mechanics of the
uniform electron gas. Journal de l’Ecole Polytechnique - Mathematiques.
Ecole Polytechnique. https://doi.org/10.5802/jep.64
chicago: Lewi, Mathieu, Élliott Lieb, and Robert Seiringer. “Statistical Mechanics
of the Uniform Electron Gas.” Journal de l’Ecole Polytechnique - Mathematiques.
Ecole Polytechnique, 2018. https://doi.org/10.5802/jep.64.
ieee: M. Lewi, É. Lieb, and R. Seiringer, “Statistical mechanics of the uniform
electron gas,” Journal de l’Ecole Polytechnique - Mathematiques, vol. 5.
Ecole Polytechnique, pp. 79–116, 2018.
ista: Lewi M, Lieb É, Seiringer R. 2018. Statistical mechanics of the uniform electron
gas. Journal de l’Ecole Polytechnique - Mathematiques. 5, 79–116.
mla: Lewi, Mathieu, et al. “Statistical Mechanics of the Uniform Electron Gas.”
Journal de l’Ecole Polytechnique - Mathematiques, vol. 5, Ecole Polytechnique,
2018, pp. 79–116, doi:10.5802/jep.64.
short: M. Lewi, É. Lieb, R. Seiringer, Journal de l’Ecole Polytechnique - Mathematiques
5 (2018) 79–116.
date_created: 2018-12-11T11:45:03Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2023-10-17T08:05:28Z
day: '01'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.5802/jep.64
ec_funded: 1
external_id:
arxiv:
- '1705.10676'
file:
- access_level: open_access
checksum: 1ba7cccdf3900f42c4f715ae75d6813c
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T16:38:18Z
date_updated: 2020-07-14T12:45:16Z
file_id: '5726'
file_name: 2018_JournaldeLecoleMath_Lewi.pdf
file_size: 843938
relation: main_file
file_date_updated: 2020-07-14T12:45:16Z
has_accepted_license: '1'
intvolume: ' 5'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nd/4.0/
month: '07'
oa: 1
oa_version: Published Version
page: 79 - 116
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: 25C878CE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27533_N27
name: Structure of the Excitation Spectrum for Many-Body Quantum Systems
publication: Journal de l'Ecole Polytechnique - Mathematiques
publication_identifier:
eissn:
- 2270-518X
issn:
- 2429-7100
publication_status: published
publisher: Ecole Polytechnique
publist_id: '7741'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Statistical mechanics of the uniform electron gas
tmp:
image: /image/cc_by_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nd/4.0/legalcode
name: Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
short: CC BY-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2018'
...
---
_id: '163'
abstract:
- lang: eng
text: For ultrafast fixation of biological samples to avoid artifacts, high-pressure
freezing (HPF) followed by freeze substitution (FS) is preferred over chemical
fixation at room temperature. After HPF, samples are maintained at low temperature
during dehydration and fixation, while avoiding damaging recrystallization. This
is a notoriously slow process. McDonald and Webb demonstrated, in 2011, that sample
agitation during FS dramatically reduces the necessary time. Then, in 2015, we
(H.G. and S.R.) introduced an agitation module into the cryochamber of an automated
FS unit and demonstrated that the preparation of algae could be shortened from
days to a couple of hours. We argued that variability in the processing, reproducibility,
and safety issues are better addressed using automated FS units. For dissemination,
we started low-cost manufacturing of agitation modules for two of the most widely
used FS units, the Automatic Freeze Substitution Systems, AFS(1) and AFS2, from
Leica Microsystems, using three dimensional (3D)-printing of the major components.
To test them, several labs independently used the modules on a wide variety of
specimens that had previously been processed by manual agitation, or without agitation.
We demonstrate that automated processing with sample agitation saves time, increases
flexibility with respect to sample requirements and protocols, and produces data
of at least as good quality as other approaches.
article_processing_charge: No
article_type: original
author:
- first_name: Siegfried
full_name: Reipert, Siegfried
last_name: Reipert
- first_name: Helmuth
full_name: Goldammer, Helmuth
last_name: Goldammer
- first_name: Christine
full_name: Richardson, Christine
last_name: Richardson
- first_name: Martin
full_name: Goldberg, Martin
last_name: Goldberg
- first_name: Timothy
full_name: Hawkins, Timothy
last_name: Hawkins
- first_name: Elena
full_name: Hollergschwandtner, Elena
id: 3C054040-F248-11E8-B48F-1D18A9856A87
last_name: Hollergschwandtner
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Sebastian
full_name: Antreich, Sebastian
last_name: Antreich
- first_name: York
full_name: Stierhof, York
last_name: Stierhof
citation:
ama: 'Reipert S, Goldammer H, Richardson C, et al. Agitation modules: Flexible means
to accelerate automated freeze substitution. Journal of Histochemistry and
Cytochemistry. 2018;66(12):903-921. doi:10.1369/0022155418786698'
apa: 'Reipert, S., Goldammer, H., Richardson, C., Goldberg, M., Hawkins, T., Saeckl,
E., … Stierhof, Y. (2018). Agitation modules: Flexible means to accelerate automated
freeze substitution. Journal of Histochemistry and Cytochemistry. SAGE
Publications. https://doi.org/10.1369/0022155418786698'
chicago: 'Reipert, Siegfried, Helmuth Goldammer, Christine Richardson, Martin Goldberg,
Timothy Hawkins, Elena Saeckl, Walter Kaufmann, Sebastian Antreich, and York Stierhof.
“Agitation Modules: Flexible Means to Accelerate Automated Freeze Substitution.”
Journal of Histochemistry and Cytochemistry. SAGE Publications, 2018. https://doi.org/10.1369/0022155418786698.'
ieee: 'S. Reipert et al., “Agitation modules: Flexible means to accelerate
automated freeze substitution,” Journal of Histochemistry and Cytochemistry,
vol. 66, no. 12. SAGE Publications, pp. 903–921, 2018.'
ista: 'Reipert S, Goldammer H, Richardson C, Goldberg M, Hawkins T, Saeckl E, Kaufmann
W, Antreich S, Stierhof Y. 2018. Agitation modules: Flexible means to accelerate
automated freeze substitution. Journal of Histochemistry and Cytochemistry. 66(12),
903–921.'
mla: 'Reipert, Siegfried, et al. “Agitation Modules: Flexible Means to Accelerate
Automated Freeze Substitution.” Journal of Histochemistry and Cytochemistry,
vol. 66, no. 12, SAGE Publications, 2018, pp. 903–21, doi:10.1369/0022155418786698.'
short: S. Reipert, H. Goldammer, C. Richardson, M. Goldberg, T. Hawkins, E. Saeckl,
W. Kaufmann, S. Antreich, Y. Stierhof, Journal of Histochemistry and Cytochemistry
66 (2018) 903–921.
date_created: 2018-12-11T11:44:57Z
date_published: 2018-12-01T00:00:00Z
date_updated: 2023-10-17T08:42:24Z
day: '01'
department:
- _id: RySh
- _id: EM-Fac
doi: 10.1369/0022155418786698
external_id:
isi:
- '000452277700005'
pmid:
- '29969056'
intvolume: ' 66'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1369/0022155418786698
month: '12'
oa: 1
oa_version: Published Version
page: 903-921
pmid: 1
publication: Journal of Histochemistry and Cytochemistry
publication_identifier:
issn:
- 0022-1554
publication_status: published
publisher: SAGE Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Agitation modules: Flexible means to accelerate automated freeze substitution'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2018'
...