[{"intvolume":" 543","month":"03","scopus_import":"1","oa_version":"None","abstract":[{"text":"Many organ surfaces are covered by a protective epithelial-cell layer. It emerges that such layers are maintained by cell stretching that triggers cell division mediated by the force-sensitive ion-channel protein Piezo1. See Letter p.118","lang":"eng"}],"volume":543,"issue":"7643","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["00280836"]},"status":"public","type":"journal_article","_id":"1025","department":[{"_id":"CaHe"}],"date_updated":"2023-09-22T09:26:59Z","publisher":"Nature Publishing Group","quality_controlled":"1","date_created":"2018-12-11T11:49:45Z","doi":"10.1038/nature21502","date_published":"2017-03-02T00:00:00Z","page":"43 - 44","publication":"Nature","day":"02","year":"2017","isi":1,"title":"Cell biology: Stretched divisions","article_processing_charge":"No","external_id":{"isi":["000395671500025"]},"publist_id":"6367","author":[{"first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"short":"C.-P.J. Heisenberg, Nature 543 (2017) 43–44.","ieee":"C.-P. J. Heisenberg, “Cell biology: Stretched divisions,” Nature, vol. 543, no. 7643. Nature Publishing Group, pp. 43–44, 2017.","ama":"Heisenberg C-PJ. Cell biology: Stretched divisions. Nature. 2017;543(7643):43-44. doi:10.1038/nature21502","apa":"Heisenberg, C.-P. J. (2017). Cell biology: Stretched divisions. Nature. Nature Publishing Group. https://doi.org/10.1038/nature21502","mla":"Heisenberg, Carl-Philipp J. “Cell Biology: Stretched Divisions.” Nature, vol. 543, no. 7643, Nature Publishing Group, 2017, pp. 43–44, doi:10.1038/nature21502.","ista":"Heisenberg C-PJ. 2017. Cell biology: Stretched divisions. Nature. 543(7643), 43–44.","chicago":"Heisenberg, Carl-Philipp J. “Cell Biology: Stretched Divisions.” Nature. Nature Publishing Group, 2017. https://doi.org/10.1038/nature21502."}},{"scopus_import":"1","month":"10","intvolume":" 84","abstract":[{"text":"The development of the vertebrate central nervous system is reliant on a complex cascade of biological processes that include mitotic division, relocation of migrating neurons, and the extension of dendritic and axonal processes. Each of these cellular events requires the diverse functional repertoire of the microtubule cytoskeleton for the generation of forces, assembly of macromolecular complexes and transport of molecules and organelles. The tubulins are a multi-gene family that encode for the constituents of microtubules, and have been implicated in a spectrum of neurological disorders. Evidence is building that different tubulins tune the functional properties of the microtubule cytoskeleton dependent on the cell type, developmental profile and subcellular localisation. Here we review of the origins of the functional specification of the tubulin gene family in the developing brain at a transcriptional, translational, and post-transcriptional level. We remind the reader that tubulins are not just loading controls for your average Western blot.","lang":"eng"}],"oa_version":"Published Version","volume":84,"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","publication_identifier":{"issn":["10447431"]},"publication_status":"published","file":[{"file_id":"4742","content_type":"application/pdf","access_level":"open_access","relation":"main_file","date_created":"2018-12-12T10:09:19Z","file_name":"IST-2017-806-v1+2_1-s2.0-S1044743116302500-main_1_.pdf","date_updated":"2018-12-12T10:09:19Z","file_size":1436377,"creator":"system"}],"language":[{"iso":"eng"}],"type":"journal_article","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"status":"public","pubrep_id":"806","_id":"1017","department":[{"_id":"SiHi"}],"file_date_updated":"2018-12-12T10:09:19Z","date_updated":"2023-09-22T09:42:15Z","ddc":["571"],"publisher":"Academic Press","quality_controlled":"1","oa":1,"page":"58 - 67","date_published":"2017-10-01T00:00:00Z","doi":"10.1016/j.mcn.2017.03.002","date_created":"2018-12-11T11:49:42Z","has_accepted_license":"1","isi":1,"year":"2017","day":"01","publication":"Molecular and Cellular Neuroscience","publist_id":"6377","author":[{"full_name":"Breuss, Martin","last_name":"Breuss","first_name":"Martin"},{"first_name":"Ines","full_name":"Leca, Ines","last_name":"Leca"},{"full_name":"Gstrein, Thomas","last_name":"Gstrein","first_name":"Thomas"},{"full_name":"Hansen, Andi H","last_name":"Hansen","first_name":"Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Keays","full_name":"Keays, David","first_name":"David"}],"article_processing_charge":"No","external_id":{"isi":["000415140700007"]},"title":"Tubulins and brain development: The origins of functional specification","citation":{"mla":"Breuss, Martin, et al. “Tubulins and Brain Development: The Origins of Functional Specification.” Molecular and Cellular Neuroscience, vol. 84, Academic Press, 2017, pp. 58–67, doi:10.1016/j.mcn.2017.03.002.","ieee":"M. Breuss, I. Leca, T. Gstrein, A. H. Hansen, and D. Keays, “Tubulins and brain development: The origins of functional specification,” Molecular and Cellular Neuroscience, vol. 84. Academic Press, pp. 58–67, 2017.","short":"M. Breuss, I. Leca, T. Gstrein, A.H. Hansen, D. Keays, Molecular and Cellular Neuroscience 84 (2017) 58–67.","ama":"Breuss M, Leca I, Gstrein T, Hansen AH, Keays D. Tubulins and brain development: The origins of functional specification. Molecular and Cellular Neuroscience. 2017;84:58-67. doi:10.1016/j.mcn.2017.03.002","apa":"Breuss, M., Leca, I., Gstrein, T., Hansen, A. H., & Keays, D. (2017). Tubulins and brain development: The origins of functional specification. Molecular and Cellular Neuroscience. Academic Press. https://doi.org/10.1016/j.mcn.2017.03.002","chicago":"Breuss, Martin, Ines Leca, Thomas Gstrein, Andi H Hansen, and David Keays. “Tubulins and Brain Development: The Origins of Functional Specification.” Molecular and Cellular Neuroscience. Academic Press, 2017. https://doi.org/10.1016/j.mcn.2017.03.002.","ista":"Breuss M, Leca I, Gstrein T, Hansen AH, Keays D. 2017. Tubulins and brain development: The origins of functional specification. Molecular and Cellular Neuroscience. 84, 58–67."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"article_number":"45702","title":"Vortices and antivortices in two-dimensional ultracold Fermi gases","article_processing_charge":"No","external_id":{"isi":["000398148100001"]},"author":[{"last_name":"Bighin","full_name":"Bighin, Giacomo","orcid":"0000-0001-8823-9777","id":"4CA96FD4-F248-11E8-B48F-1D18A9856A87","first_name":"Giacomo"},{"first_name":"Luca","full_name":"Salasnich, Luca","last_name":"Salasnich"}],"publist_id":"6380","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"chicago":"Bighin, Giacomo, and Luca Salasnich. “Vortices and Antivortices in Two-Dimensional Ultracold Fermi Gases.” Scientific Reports. Nature Publishing Group, 2017. https://doi.org/10.1038/srep45702.","ista":"Bighin G, Salasnich L. 2017. Vortices and antivortices in two-dimensional ultracold Fermi gases. Scientific Reports. 7, 45702.","mla":"Bighin, Giacomo, and Luca Salasnich. “Vortices and Antivortices in Two-Dimensional Ultracold Fermi Gases.” Scientific Reports, vol. 7, 45702, Nature Publishing Group, 2017, doi:10.1038/srep45702.","short":"G. Bighin, L. Salasnich, Scientific Reports 7 (2017).","ieee":"G. Bighin and L. Salasnich, “Vortices and antivortices in two-dimensional ultracold Fermi gases,” Scientific Reports, vol. 7. Nature Publishing Group, 2017.","apa":"Bighin, G., & Salasnich, L. (2017). Vortices and antivortices in two-dimensional ultracold Fermi gases. Scientific Reports. Nature Publishing Group. https://doi.org/10.1038/srep45702","ama":"Bighin G, Salasnich L. Vortices and antivortices in two-dimensional ultracold Fermi gases. Scientific Reports. 2017;7. doi:10.1038/srep45702"},"oa":1,"quality_controlled":"1","publisher":"Nature Publishing Group","date_created":"2018-12-11T11:49:42Z","doi":"10.1038/srep45702","date_published":"2017-04-04T00:00:00Z","publication":"Scientific Reports","day":"04","year":"2017","has_accepted_license":"1","isi":1,"pubrep_id":"809","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","_id":"1015","file_date_updated":"2018-12-12T10:12:32Z","department":[{"_id":"MiLe"}],"ddc":["539"],"date_updated":"2023-09-22T09:43:10Z","intvolume":" 7","month":"04","scopus_import":"1","oa_version":"Published Version","abstract":[{"text":"Vortices are commonly observed in the context of classical hydrodynamics: from whirlpools after stirring the coffee in a cup to a violent atmospheric phenomenon such as a tornado, all classical vortices are characterized by an arbitrary circulation value of the local velocity field. On the other hand the appearance of vortices with quantized circulation represents one of the fundamental signatures of macroscopic quantum phenomena. In two-dimensional superfluids quantized vortices play a key role in determining finite-temperature properties, as the superfluid phase and the normal state are separated by a vortex unbinding transition, the Berezinskii-Kosterlitz-Thouless transition. Very recent experiments with two-dimensional superfluid fermions motivate the present work: we present theoretical results based on the renormalization group showing that the universal jump of the superfluid density and the critical temperature crucially depend on the interaction strength, providing a strong benchmark for forthcoming investigations.","lang":"eng"}],"volume":7,"language":[{"iso":"eng"}],"file":[{"access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"4950","creator":"system","date_updated":"2018-12-12T10:12:32Z","file_size":478289,"date_created":"2018-12-12T10:12:32Z","file_name":"IST-2017-809-v1+1_srep45702.pdf"}],"publication_status":"published","publication_identifier":{"issn":["20452322"]}},{"_id":"1016","status":"public","type":"journal_article","date_updated":"2023-09-22T09:42:42Z","department":[{"_id":"SiHi"}],"oa_version":"None","abstract":[{"text":"The integrity and dynamic properties of the microtubule cytoskeleton are indispensable for the development of the mammalian brain. Consequently, mutations in the genes that encode the structural component (the α/β-tubulin heterodimer) can give rise to severe, sporadic neurodevelopmental disorders. These are commonly referred to as the tubulinopathies. Here we report the addition of recessive quadrupedalism, also known as Uner Tan syndrome (UTS), to the growing list of diseases caused by tubulin variants. Analysis of a consanguineous UTS family identified a biallelic TUBB2B mutation, resulting in a p.R390Q amino acid substitution. In addition to the identifying quadrupedal locomotion, all three patients showed severe cerebellar hypoplasia. None, however, displayed the basal ganglia malformations typically associated with TUBB2B mutations. Functional analysis of the R390Q substitution revealed that it did not affect the ability of β-tubulin to fold or become assembled into the α/β-heterodimer, nor did it influence the incorporation of mutant-containing heterodimers into microtubule polymers. The 390Q mutation in S. cerevisiae TUB2 did not affect growth under basal conditions, but did result in increased sensitivity to microtubule-depolymerizing drugs, indicative of a mild impact of this mutation on microtubule function. The TUBB2B mutation described here represents an unusual recessive mode of inheritance for missense-mediated tubulinopathies and reinforces the sensitivity of the developing cerebellum to microtubule defects.","lang":"eng"}],"month":"01","intvolume":" 26","scopus_import":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["09646906"]},"publication_status":"published","volume":26,"issue":"2","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"mla":"Breuss, Martin, et al. “Uner Tan Syndrome Caused by a Homozygous TUBB2B Mutation Affecting Microtubule Stability.” Human Molecular Genetics, vol. 26, no. 2, Oxford University Press, 2017, pp. 258–69, doi:10.1093/hmg/ddw383.","ama":"Breuss M, Nguyen T, Srivatsan A, et al. Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability. Human Molecular Genetics. 2017;26(2):258-269. doi:10.1093/hmg/ddw383","apa":"Breuss, M., Nguyen, T., Srivatsan, A., Leca, I., Tian, G., Fritz, T., … Gleeson, J. (2017). Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability. Human Molecular Genetics. Oxford University Press. https://doi.org/10.1093/hmg/ddw383","short":"M. Breuss, T. Nguyen, A. Srivatsan, I. Leca, G. Tian, T. Fritz, A.H. Hansen, D. Musaev, J. Mcevoy Venneri, J. Kiely, R. Rosti, E. Scott, U. Tan, R. Kolodner, N. Cowan, D. Keays, J. Gleeson, Human Molecular Genetics 26 (2017) 258–269.","ieee":"M. Breuss et al., “Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability,” Human Molecular Genetics, vol. 26, no. 2. Oxford University Press, pp. 258–269, 2017.","chicago":"Breuss, Martin, Thai Nguyen, Anjana Srivatsan, Ines Leca, Guoling Tian, Tanja Fritz, Andi H Hansen, et al. “Uner Tan Syndrome Caused by a Homozygous TUBB2B Mutation Affecting Microtubule Stability.” Human Molecular Genetics. Oxford University Press, 2017. https://doi.org/10.1093/hmg/ddw383.","ista":"Breuss M, Nguyen T, Srivatsan A, Leca I, Tian G, Fritz T, Hansen AH, Musaev D, Mcevoy Venneri J, Kiely J, Rosti R, Scott E, Tan U, Kolodner R, Cowan N, Keays D, Gleeson J. 2017. Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability. Human Molecular Genetics. 26(2), 258–269."},"title":"Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability","author":[{"first_name":"Martin","full_name":"Breuss, Martin","last_name":"Breuss"},{"first_name":"Thai","full_name":"Nguyen, Thai","last_name":"Nguyen"},{"full_name":"Srivatsan, Anjana","last_name":"Srivatsan","first_name":"Anjana"},{"first_name":"Ines","full_name":"Leca, Ines","last_name":"Leca"},{"first_name":"Guoling","last_name":"Tian","full_name":"Tian, Guoling"},{"first_name":"Tanja","last_name":"Fritz","full_name":"Fritz, Tanja"},{"last_name":"Hansen","full_name":"Hansen, Andi H","first_name":"Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Damir","full_name":"Musaev, Damir","last_name":"Musaev"},{"first_name":"Jennifer","last_name":"Mcevoy Venneri","full_name":"Mcevoy Venneri, Jennifer"},{"first_name":"James","last_name":"Kiely","full_name":"Kiely, James"},{"first_name":"Rasim","last_name":"Rosti","full_name":"Rosti, Rasim"},{"first_name":"Eric","full_name":"Scott, Eric","last_name":"Scott"},{"last_name":"Tan","full_name":"Tan, Uner","first_name":"Uner"},{"first_name":"Richard","last_name":"Kolodner","full_name":"Kolodner, Richard"},{"full_name":"Cowan, Nicholas","last_name":"Cowan","first_name":"Nicholas"},{"first_name":"David","last_name":"Keays","full_name":"Keays, David"},{"first_name":"Joseph","full_name":"Gleeson, Joseph","last_name":"Gleeson"}],"publist_id":"6379","article_processing_charge":"No","external_id":{"isi":["000397066400002"]},"publisher":"Oxford University Press","quality_controlled":"1","day":"01","publication":"Human Molecular Genetics","isi":1,"year":"2017","date_published":"2017-01-01T00:00:00Z","doi":"10.1093/hmg/ddw383","date_created":"2018-12-11T11:49:42Z","page":"258 - 269"},{"_id":"1018","type":"journal_article","status":"public","date_updated":"2023-09-22T09:41:48Z","department":[{"_id":"EvBe"}],"abstract":[{"lang":"eng","text":"In plants, the multistep phosphorelay (MSP) pathway mediates a range of regulatory processes, including those activated by cytokinins. The crosstalk between cytokinin response and light is known for a long time. However, the molecular mechanism underlying the interactionbetween light and cytokinin signaling remains elusive. In the screen for upstream regulators we identified a LONG PALE HYPOCOTYL (LPH) gene whose activity is indispensable for spatiotemporally correct expression of CYTOKININ INDEPENDENT-1 (CKI1), encoding the constitutively active sensor histidine kinase that activates MSP signaling. lph is a new allele of HEME OXYGENASE 1 (HY1) which encodes the key protein in the biosynthesis of phytochromobilin, a cofactor of photoconvertiblephytochromes. Our analysis confirmed the light-dependent regulation oftheCKI1 expression pattern. We show that CKI1 expression is under the control of phytochrome A (phyA), functioning as a dual (both positive and negative) regulator of CKI1 expression, presumably via the phyA-regulated transcription factors PHYTOCHROME INTERACTING FACTOR 3 (PIF3) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1). Changes in CKI1 expression observed in lph/hy1-7 and phy mutants correlatewithmisregulation of MSP signaling, changedcytokinin sensitivity and developmental aberrations,previously shown to be associated with cytokinin and/or CKI1 action. Besides that, we demonstrate novel role of phyA-dependent CKI1 expression in the hypocotyl elongation and hook development during skotomorphogenesis. Based on these results, we propose that the light-dependent regulation of CKI1 provides a plausible mechanistic link underlying the well-known interaction between light- and cytokinin-controlled plant development."}],"oa_version":"None","scopus_import":"1","intvolume":" 174","month":"05","publication_status":"published","language":[{"iso":"eng"}],"volume":174,"issue":"1","citation":{"ista":"Dobisova T, Hrdinova V, Cuesta C, Michlickova S, Urbankova I, Hejatkova R, Zadnikova P, Pernisová M, Benková E, Hejátko J. 2017. Light regulated expression of sensor histidine kinase CKI1 controls cytokinin related development. Plant Physiology. 174(1), 387–404.","chicago":"Dobisova, Tereza, Vendula Hrdinova, Candela Cuesta, Sarka Michlickova, Ivana Urbankova, Romana Hejatkova, Petra Zadnikova, Markéta Pernisová, Eva Benková, and Jan Hejátko. “Light Regulated Expression of Sensor Histidine Kinase CKI1 Controls Cytokinin Related Development.” Plant Physiology. American Society of Plant Biologists, 2017. https://doi.org/10.1104/pp.16.01964.","ama":"Dobisova T, Hrdinova V, Cuesta C, et al. Light regulated expression of sensor histidine kinase CKI1 controls cytokinin related development. Plant Physiology. 2017;174(1):387-404. doi:10.1104/pp.16.01964","apa":"Dobisova, T., Hrdinova, V., Cuesta, C., Michlickova, S., Urbankova, I., Hejatkova, R., … Hejátko, J. (2017). Light regulated expression of sensor histidine kinase CKI1 controls cytokinin related development. Plant Physiology. American Society of Plant Biologists. https://doi.org/10.1104/pp.16.01964","ieee":"T. Dobisova et al., “Light regulated expression of sensor histidine kinase CKI1 controls cytokinin related development,” Plant Physiology, vol. 174, no. 1. American Society of Plant Biologists, pp. 387–404, 2017.","short":"T. Dobisova, V. Hrdinova, C. Cuesta, S. Michlickova, I. Urbankova, R. Hejatkova, P. Zadnikova, M. Pernisová, E. Benková, J. Hejátko, Plant Physiology 174 (2017) 387–404.","mla":"Dobisova, Tereza, et al. “Light Regulated Expression of Sensor Histidine Kinase CKI1 Controls Cytokinin Related Development.” Plant Physiology, vol. 174, no. 1, American Society of Plant Biologists, 2017, pp. 387–404, doi:10.1104/pp.16.01964."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","external_id":{"isi":["000402057200028"]},"article_processing_charge":"No","publist_id":"6375","author":[{"first_name":"Tereza","full_name":"Dobisova, Tereza","last_name":"Dobisova"},{"last_name":"Hrdinova","full_name":"Hrdinova, Vendula","first_name":"Vendula"},{"orcid":"0000-0003-1923-2410","full_name":"Cuesta, Candela","last_name":"Cuesta","first_name":"Candela","id":"33A3C818-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Michlickova","full_name":"Michlickova, Sarka","first_name":"Sarka"},{"first_name":"Ivana","full_name":"Urbankova, Ivana","last_name":"Urbankova"},{"first_name":"Romana","last_name":"Hejatkova","full_name":"Hejatkova, Romana"},{"full_name":"Zadnikova, Petra","last_name":"Zadnikova","first_name":"Petra"},{"first_name":"Markéta","full_name":"Pernisová, Markéta","last_name":"Pernisová"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","last_name":"Benková","full_name":"Benková, Eva","orcid":"0000-0002-8510-9739"},{"first_name":"Jan","full_name":"Hejátko, Jan","last_name":"Hejátko"}],"title":"Light regulated expression of sensor histidine kinase CKI1 controls cytokinin related development","quality_controlled":"1","publisher":"American Society of Plant Biologists","year":"2017","isi":1,"publication":"Plant Physiology","day":"17","page":"387 - 404","date_created":"2018-12-11T11:49:43Z","date_published":"2017-05-17T00:00:00Z","doi":"10.1104/pp.16.01964"}]