[{"file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","success":1,"checksum":"310748d140c8838335c1314431095898","file_id":"9370","file_size":3379349,"date_updated":"2021-05-04T12:41:38Z","creator":"kschuh","file_name":"2021_mSphere_Gast.pdf","date_created":"2021-05-04T12:41:38Z"}],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["23795042"]},"publication_status":"published","issue":"2","volume":6,"license":"https://creativecommons.org/licenses/by/4.0/","pmid":1,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"The multimeric matrix (M) protein of clinically relevant paramyxoviruses orchestrates assembly and budding activity of viral particles at the plasma membrane (PM). We identified within the canine distemper virus (CDV) M protein two microdomains, potentially assuming α-helix structures, which are essential for membrane budding activity. Remarkably, while two rationally designed microdomain M mutants (E89R, microdomain 1 and L239D, microdomain 2) preserved proper folding, dimerization, interaction with the nucleocapsid protein, localization at and deformation of the PM, the virus-like particle formation, as well as production of infectious virions (as monitored using a membrane budding-complementation system), were, in sharp contrast, strongly impaired. Of major importance, raster image correlation spectroscopy (RICS) revealed that both microdomains contributed to finely tune M protein mobility specifically at the PM. Collectively, our data highlighted the cornerstone membrane budding-priming activity of two spatially discrete M microdomains, potentially by coordinating the assembly of productive higher oligomers at the PM."}],"month":"04","intvolume":" 6","scopus_import":"1","ddc":["570"],"date_updated":"2023-08-08T13:26:12Z","file_date_updated":"2021-05-04T12:41:38Z","department":[{"_id":"Bio"}],"_id":"9361","status":"public","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"day":"14","publication":"mSphere","isi":1,"has_accepted_license":"1","year":"2021","date_published":"2021-04-14T00:00:00Z","doi":"10.1128/mSphere.01024-20","date_created":"2021-05-02T22:01:28Z","acknowledgement":"This work was supported by the Swiss National Science Foundation (referencenumber 310030_173185 to P. P.).","publisher":"American Society for Microbiology","quality_controlled":"1","oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"mla":"Gast, Matthieu, et al. “Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein.” MSphere, vol. 6, no. 2, e01024-20, American Society for Microbiology, 2021, doi:10.1128/mSphere.01024-20.","ama":"Gast M, Kadzioch NP, Milius D, Origgi F, Plattet P. Oligomerization and cell egress controlled by two microdomains of canine distemper virus matrix protein. mSphere. 2021;6(2). doi:10.1128/mSphere.01024-20","apa":"Gast, M., Kadzioch, N. P., Milius, D., Origgi, F., & Plattet, P. (2021). Oligomerization and cell egress controlled by two microdomains of canine distemper virus matrix protein. MSphere. American Society for Microbiology. https://doi.org/10.1128/mSphere.01024-20","short":"M. Gast, N.P. Kadzioch, D. Milius, F. Origgi, P. Plattet, MSphere 6 (2021).","ieee":"M. Gast, N. P. Kadzioch, D. Milius, F. Origgi, and P. Plattet, “Oligomerization and cell egress controlled by two microdomains of canine distemper virus matrix protein,” mSphere, vol. 6, no. 2. American Society for Microbiology, 2021.","chicago":"Gast, Matthieu, Nicole P. Kadzioch, Doreen Milius, Francesco Origgi, and Philippe Plattet. “Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein.” MSphere. American Society for Microbiology, 2021. https://doi.org/10.1128/mSphere.01024-20.","ista":"Gast M, Kadzioch NP, Milius D, Origgi F, Plattet P. 2021. Oligomerization and cell egress controlled by two microdomains of canine distemper virus matrix protein. mSphere. 6(2), e01024-20."},"title":"Oligomerization and cell egress controlled by two microdomains of canine distemper virus matrix protein","author":[{"first_name":"Matthieu","full_name":"Gast, Matthieu","last_name":"Gast"},{"full_name":"Kadzioch, Nicole P.","last_name":"Kadzioch","first_name":"Nicole P."},{"last_name":"Milius","full_name":"Milius, Doreen","first_name":"Doreen","id":"384050BC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Origgi","full_name":"Origgi, Francesco","first_name":"Francesco"},{"first_name":"Philippe","full_name":"Plattet, Philippe","last_name":"Plattet"}],"external_id":{"isi":["000663823400025"],"pmid":["33853875"]},"article_processing_charge":"No","article_number":"e01024-20"},{"ddc":["000"],"date_updated":"2023-08-08T13:31:38Z","file_date_updated":"2021-12-17T08:13:51Z","department":[{"_id":"BeBi"}],"_id":"9376","status":"public","keyword":["multistability","mechanism","computational design","rigidity"],"article_type":"original","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"file_size":18926557,"date_updated":"2021-05-08T17:36:59Z","creator":"bbickel","file_name":"Multistable-authorversion.pdf","date_created":"2021-05-08T17:36:59Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_id":"9377","checksum":"8564b3118457d4c8939a8ef2b1a2f16c"},{"creator":"bbickel","file_size":76542901,"date_updated":"2021-05-08T17:38:22Z","file_name":"multistable-video.mp4","date_created":"2021-05-08T17:38:22Z","relation":"main_file","access_level":"open_access","content_type":"video/mp4","success":1,"checksum":"3b6e874e30bfa1bfc3ad3498710145a1","file_id":"9378"},{"description":"This document provides additional results and analyzes the robustness and limitations of our approach.","content_type":"application/pdf","access_level":"open_access","relation":"supplementary_material","file_id":"10562","checksum":"20dc3bc42e1a912a5b0247c116772098","date_updated":"2021-12-17T08:13:51Z","file_size":3367072,"creator":"bbickel","title":"Supplementary Material for “Computational Design of Planar Multistable Compliant Structures”","date_created":"2021-12-17T08:13:51Z","file_name":"multistable-supplementary material.pdf"}],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1557-7368"],"issn":["0730-0301"]},"publication_status":"published","issue":"5","volume":40,"ec_funded":1,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"This paper presents a method for designing planar multistable compliant structures. Given a sequence of desired stable states and the corresponding poses of the structure, we identify the topology and geometric realization of a mechanism—consisting of bars and joints—that is able to physically reproduce the desired multistable behavior. In order to solve this problem efficiently, we build on insights from minimally rigid graph theory to identify simple but effective topologies for the mechanism. We then optimize its geometric parameters, such as joint positions and bar lengths, to obtain correct transitions between the given poses. Simultaneously, we ensure adequate stability of each pose based on an effective approximate error metric related to the elastic energy Hessian of the bars in the mechanism. As demonstrated by our results, we obtain functional multistable mechanisms of manageable complexity that can be fabricated using 3D printing. Further, we evaluated the effectiveness of our method on a large number of examples in the simulation and fabricated several physical prototypes."}],"acknowledged_ssus":[{"_id":"M-Shop"}],"month":"10","intvolume":" 40","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ama":"Zhang R, Auzinger T, Bickel B. Computational design of planar multistable compliant structures. ACM Transactions on Graphics. 2021;40(5). doi:10.1145/3453477","apa":"Zhang, R., Auzinger, T., & Bickel, B. (2021). Computational design of planar multistable compliant structures. ACM Transactions on Graphics. Association for Computing Machinery. https://doi.org/10.1145/3453477","ieee":"R. Zhang, T. Auzinger, and B. Bickel, “Computational design of planar multistable compliant structures,” ACM Transactions on Graphics, vol. 40, no. 5. Association for Computing Machinery, 2021.","short":"R. Zhang, T. Auzinger, B. Bickel, ACM Transactions on Graphics 40 (2021).","mla":"Zhang, Ran, et al. “Computational Design of Planar Multistable Compliant Structures.” ACM Transactions on Graphics, vol. 40, no. 5, 186, Association for Computing Machinery, 2021, doi:10.1145/3453477.","ista":"Zhang R, Auzinger T, Bickel B. 2021. Computational design of planar multistable compliant structures. ACM Transactions on Graphics. 40(5), 186.","chicago":"Zhang, Ran, Thomas Auzinger, and Bernd Bickel. “Computational Design of Planar Multistable Compliant Structures.” ACM Transactions on Graphics. Association for Computing Machinery, 2021. https://doi.org/10.1145/3453477."},"title":"Computational design of planar multistable compliant structures","author":[{"last_name":"Zhang","orcid":"0000-0002-3808-281X","full_name":"Zhang, Ran","id":"4DDBCEB0-F248-11E8-B48F-1D18A9856A87","first_name":"Ran"},{"id":"4718F954-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas","last_name":"Auzinger","orcid":"0000-0002-1546-3265","full_name":"Auzinger, Thomas"},{"full_name":"Bickel, Bernd","orcid":"0000-0001-6511-9385","last_name":"Bickel","id":"49876194-F248-11E8-B48F-1D18A9856A87","first_name":"Bernd"}],"article_processing_charge":"No","external_id":{"isi":["000752079300003"]},"article_number":"186","project":[{"_id":"2508E324-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Distributed 3D Object Design","grant_number":"642841"},{"call_identifier":"H2020","_id":"24F9549A-B435-11E9-9278-68D0E5697425","grant_number":"715767","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling"}],"day":"08","publication":"ACM Transactions on Graphics","has_accepted_license":"1","isi":1,"year":"2021","date_published":"2021-10-08T00:00:00Z","doi":"10.1145/3453477","date_created":"2021-05-08T17:37:08Z","acknowledgement":"We would like to thank everyone who contributed to this paper, the authors of artworks for all the examples, including @macrovec-tor_official and Wikimedia for the FLAG semaphore, and @pikisuper-star for the FIGURINE. The photos of iconic poses in the teaser were supplied by (from left to right): Mike Hewitt/Olympics Day 8 - Athletics/Gettty Images, Oneinchpunch/Basketball player training on acourt in New york city/Shutterstock, and Andrew Redington/TigerWoods/Getty Images. We also want to express our gratitude to Christian Hafner for insightful discussions, the IST Austria machine shop SSU, all proof-readers, and anonymous reviewers. This project has received funding from the European Union’s Horizon 2020 research and innovation programme, under the Marie Skłodowska-Curie grant agreement No 642841 (DISTRO), and under the European Research Council grant agreement No 715767 (MATERIALIZABLE).","publisher":"Association for Computing Machinery","quality_controlled":"1","oa":1},{"_id":"9375","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"type":"journal_article","article_type":"original","status":"public","date_updated":"2023-08-08T13:33:09Z","ddc":["570"],"file_date_updated":"2022-03-08T08:18:16Z","department":[{"_id":"NiBa"}],"abstract":[{"lang":"eng","text":"Genetic variation segregates as linked sets of variants, or haplotypes. Haplotypes and linkage are central to genetics and underpin virtually all genetic and selection analysis. And yet, genomic data often lack haplotype information, due to constraints in sequencing technologies. Here we present “haplotagging”, a simple, low-cost linked-read sequencing technique that allows sequencing of hundreds of individuals while retaining linkage information. We apply haplotagging to construct megabase-size haplotypes for over 600 individual butterflies (Heliconius erato and H. melpomene), which form overlapping hybrid zones across an elevational gradient in Ecuador. Haplotagging identifies loci controlling distinctive high- and lowland wing color patterns. Divergent haplotypes are found at the same major loci in both species, while chromosome rearrangements show no parallelism. Remarkably, in both species the geographic clines for the major wing pattern loci are displaced by 18 km, leading to the rise of a novel hybrid morph in the centre of the hybrid zone. We propose that shared warning signalling (Müllerian mimicry) may couple the cline shifts seen in both species, and facilitate the parallel co-emergence of a novel hybrid morph in both co-mimetic species. Our results show the power of efficient haplotyping methods when combined with large-scale sequencing data from natural populations."}],"oa_version":"Published Version","pmid":1,"scopus_import":"1","intvolume":" 118","month":"06","publication_status":"published","publication_identifier":{"eissn":["0027-8424"]},"language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","success":1,"file_id":"10835","checksum":"cb30c6166b2132ee60d616b31a1a7c29","file_size":20592929,"date_updated":"2022-03-08T08:18:16Z","creator":"dernst","file_name":"2021_PNAS_Meier.pdf","date_created":"2022-03-08T08:18:16Z"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","issue":"25","volume":118,"article_number":"e2015005118","citation":{"ista":"Meier JI, Salazar PA, Kučka M, Davies RW, Dréau A, Aldás I, Power OB, Nadeau NJ, Bridle JR, Rolian C, Barton NH, McMillan WO, Jiggins CD, Chan YF. 2021. Haplotype tagging reveals parallel formation of hybrid races in two butterfly species. PNAS. 118(25), e2015005118.","chicago":"Meier, Joana I., Patricio A. Salazar, Marek Kučka, Robert William Davies, Andreea Dréau, Ismael Aldás, Olivia Box Power, et al. “Haplotype Tagging Reveals Parallel Formation of Hybrid Races in Two Butterfly Species.” PNAS. Proceedings of the National Academy of Sciences, 2021. https://doi.org/10.1073/pnas.2015005118.","short":"J.I. Meier, P.A. Salazar, M. Kučka, R.W. Davies, A. Dréau, I. Aldás, O.B. Power, N.J. Nadeau, J.R. Bridle, C. Rolian, N.H. Barton, W.O. McMillan, C.D. Jiggins, Y.F. Chan, PNAS 118 (2021).","ieee":"J. I. Meier et al., “Haplotype tagging reveals parallel formation of hybrid races in two butterfly species,” PNAS, vol. 118, no. 25. Proceedings of the National Academy of Sciences, 2021.","ama":"Meier JI, Salazar PA, Kučka M, et al. Haplotype tagging reveals parallel formation of hybrid races in two butterfly species. PNAS. 2021;118(25). doi:10.1073/pnas.2015005118","apa":"Meier, J. I., Salazar, P. A., Kučka, M., Davies, R. W., Dréau, A., Aldás, I., … Chan, Y. F. (2021). Haplotype tagging reveals parallel formation of hybrid races in two butterfly species. PNAS. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2015005118","mla":"Meier, Joana I., et al. “Haplotype Tagging Reveals Parallel Formation of Hybrid Races in Two Butterfly Species.” PNAS, vol. 118, no. 25, e2015005118, Proceedings of the National Academy of Sciences, 2021, doi:10.1073/pnas.2015005118."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000671755600001"],"pmid":["34155138"]},"article_processing_charge":"No","author":[{"first_name":"Joana I.","last_name":"Meier","full_name":"Meier, Joana I."},{"last_name":"Salazar","full_name":"Salazar, Patricio A.","first_name":"Patricio A."},{"full_name":"Kučka, Marek","last_name":"Kučka","first_name":"Marek"},{"full_name":"Davies, Robert William","last_name":"Davies","first_name":"Robert William"},{"first_name":"Andreea","full_name":"Dréau, Andreea","last_name":"Dréau"},{"first_name":"Ismael","last_name":"Aldás","full_name":"Aldás, Ismael"},{"first_name":"Olivia Box","last_name":"Power","full_name":"Power, Olivia Box"},{"first_name":"Nicola J.","full_name":"Nadeau, Nicola J.","last_name":"Nadeau"},{"full_name":"Bridle, Jon R.","last_name":"Bridle","first_name":"Jon R."},{"first_name":"Campbell","full_name":"Rolian, Campbell","last_name":"Rolian"},{"last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"},{"first_name":"W. Owen","full_name":"McMillan, W. Owen","last_name":"McMillan"},{"first_name":"Chris D.","full_name":"Jiggins, Chris D.","last_name":"Jiggins"},{"first_name":"Yingguang Frank","full_name":"Chan, Yingguang Frank","last_name":"Chan"}],"title":"Haplotype tagging reveals parallel formation of hybrid races in two butterfly species","acknowledgement":"We thank Felicity Jones for input into experimental design, helpful discussion and improving the manuscript. We thank the Rolian, Jiggins, Chan and Jones Labs members for support, insightful scientific discussion and improving the manuscript. We thank the Rolian lab members, the Animal Resource Centre staff at the University of Calgary, and Caroline Schmid and Ann-Katrin Geysel at the Friedrich Miescher Laboratory for animal husbandry. We thank Christa Lanz, Rebecca Schwab and Ilja Bezrukov for assistance with high-throughput sequencing and associated data processing; Andre Noll and the MPI Tübingen IT team for computational support. We thank Ben Haller and Richard Durbin for helpful discussions. We thank David M. Kingsley for thoughtful input that has greatly improved our manuscript. J.I.M. is supported by a Research Fellowship from St. John’s College, Cambridge. A.D. was supported by a European Research Council Consolidator Grant (No. 617279 “EvolRecombAdapt”, P/I Felicity Jones). C.R. is supported by Discovery Grant #4181932 from the Natural Sciences and Engineering Research Council of Canada and by the Faculty of Veterinary Medicine at the University of Calgary. C.D.J. is supported by a BBSRC grant BB/R007500 and a European Research Council Advanced Grant (No. 339873 “SpeciationGenetics”). M.K. and Y.F.C. are supported by the Max Planck Society and a European Research Council Starting Grant (No. 639096 “HybridMiX”).","oa":1,"publisher":"Proceedings of the National Academy of Sciences","quality_controlled":"1","year":"2021","isi":1,"has_accepted_license":"1","publication":"PNAS","day":"21","date_created":"2021-05-07T17:10:21Z","doi":"10.1073/pnas.2015005118","date_published":"2021-06-21T00:00:00Z"},{"oa":1,"publisher":"Wiley","quality_controlled":"1","acknowledgement":"We are very grateful to Irena Senčić for technical assistance and to Michelle Kortyna and Sean Holland at the Center for Anchored Phylogenomics for assistance with data collection. RKB was funded by the Natural Environment Research Council and by the European Research Council. KJ was funded by the Swedish Research Councils VR and Formas (Linnaeus Grant: 217‐2008‐1719). JL was funded by a studentship from the Leverhulme Centre for Advanced Biological Modelling. AMW was funded by the European Union's Horizon 2020 research and innovation program under Marie Skłodowska‐Curie Grant agreement no. 797747. RF was funded by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska‐Curie Grant agreement No. 706376 and by FEDER Funds through the Operational Competitiveness Factors Program—COMPETE and by National Funds through FCT—Foundation for Science and Technology within the scope of the project “Hybrabbid” (PTDC/BIA‐EVL/30628/2017‐ POCI‐01‐0145‐FEDER‐030628). We are grateful to other members of the Littorina research group for helpful discussions. We thank Claire Mérot and an anonymous referee for insightful comments on an earlier version. ","date_created":"2021-05-16T22:01:47Z","date_published":"2021-05-07T00:00:00Z","doi":"10.1002/evl3.227","page":"196-213","publication":"Evolution Letters","day":"07","year":"2021","has_accepted_license":"1","isi":1,"project":[{"name":"Theoretical and empirical approaches to understanding Parallel Adaptation","grant_number":"797747","_id":"265B41B8-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"title":"Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis","article_processing_charge":"No","external_id":{"isi":["000647846200001"]},"author":[{"first_name":"Eva L.","last_name":"Koch","full_name":"Koch, Eva L."},{"first_name":"Hernán E.","last_name":"Morales","full_name":"Morales, Hernán E."},{"full_name":"Larsson, Jenny","last_name":"Larsson","first_name":"Jenny"},{"id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M","orcid":"0000-0003-1050-4969","full_name":"Westram, Anja M","last_name":"Westram"},{"last_name":"Faria","full_name":"Faria, Rui","first_name":"Rui"},{"last_name":"Lemmon","full_name":"Lemmon, Alan R.","first_name":"Alan R."},{"full_name":"Lemmon, E. Moriarty","last_name":"Lemmon","first_name":"E. Moriarty"},{"first_name":"Kerstin","full_name":"Johannesson, Kerstin","last_name":"Johannesson"},{"first_name":"Roger K.","last_name":"Butlin","full_name":"Butlin, Roger K."}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Koch, Eva L., Hernán E. Morales, Jenny Larsson, Anja M Westram, Rui Faria, Alan R. Lemmon, E. Moriarty Lemmon, Kerstin Johannesson, and Roger K. Butlin. “Genetic Variation for Adaptive Traits Is Associated with Polymorphic Inversions in Littorina Saxatilis.” Evolution Letters. Wiley, 2021. https://doi.org/10.1002/evl3.227.","ista":"Koch EL, Morales HE, Larsson J, Westram AM, Faria R, Lemmon AR, Lemmon EM, Johannesson K, Butlin RK. 2021. Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. Evolution Letters. 5(3), 196–213.","mla":"Koch, Eva L., et al. “Genetic Variation for Adaptive Traits Is Associated with Polymorphic Inversions in Littorina Saxatilis.” Evolution Letters, vol. 5, no. 3, Wiley, 2021, pp. 196–213, doi:10.1002/evl3.227.","short":"E.L. Koch, H.E. Morales, J. Larsson, A.M. Westram, R. Faria, A.R. Lemmon, E.M. Lemmon, K. Johannesson, R.K. Butlin, Evolution Letters 5 (2021) 196–213.","ieee":"E. L. Koch et al., “Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis,” Evolution Letters, vol. 5, no. 3. Wiley, pp. 196–213, 2021.","apa":"Koch, E. L., Morales, H. E., Larsson, J., Westram, A. M., Faria, R., Lemmon, A. R., … Butlin, R. K. (2021). Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. Evolution Letters. Wiley. https://doi.org/10.1002/evl3.227","ama":"Koch EL, Morales HE, Larsson J, et al. Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. Evolution Letters. 2021;5(3):196-213. doi:10.1002/evl3.227"},"intvolume":" 5","month":"05","scopus_import":"1","oa_version":"Published Version","abstract":[{"text":"Chromosomal inversions have long been recognized for their role in local adaptation. By suppressing recombination in heterozygous individuals, they can maintain coadapted gene complexes and protect them from homogenizing effects of gene flow. However, to fully understand their importance for local adaptation we need to know their influence on phenotypes under divergent selection. For this, the marine snail Littorina saxatilis provides an ideal study system. Divergent ecotypes adapted to wave action and crab predation occur in close proximity on intertidal shores with gene flow between them. Here, we used F2 individuals obtained from crosses between the ecotypes to test for associations between genomic regions and traits distinguishing the Crab‐/Wave‐adapted ecotypes including size, shape, shell thickness, and behavior. We show that most of these traits are influenced by two previously detected inversion regions that are divergent between ecotypes. We thus gain a better understanding of one important underlying mechanism responsible for the rapid and repeated formation of ecotypes: divergent selection acting on inversions. We also found that some inversions contributed to more than one trait suggesting that they may contain several loci involved in adaptation, consistent with the hypothesis that suppression of recombination within inversions facilitates differentiation in the presence of gene flow.","lang":"eng"}],"ec_funded":1,"related_material":{"record":[{"id":"12987","status":"public","relation":"research_data"}]},"volume":5,"issue":"3","language":[{"iso":"eng"}],"file":[{"file_name":"2021_EvolutionLetters_Koch.pdf","date_created":"2021-10-15T08:26:02Z","creator":"cchlebak","file_size":3021108,"date_updated":"2021-10-15T08:26:02Z","success":1,"checksum":"023b1608e311f0fda30593ba3d0a4e0b","file_id":"10142","relation":"main_file","access_level":"open_access","content_type":"application/pdf"}],"publication_status":"published","publication_identifier":{"eissn":["2056-3744"]},"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","type":"journal_article","_id":"9394","file_date_updated":"2021-10-15T08:26:02Z","department":[{"_id":"NiBa"}],"ddc":["570"],"date_updated":"2023-08-08T13:34:08Z"},{"oa_version":"Published Version","abstract":[{"text":"A game of rock-paper-scissors is an interesting example of an interaction where none of the pure strategies strictly dominates all others, leading to a cyclic pattern. In this work, we consider an unstable version of rock-paper-scissors dynamics and allow individuals to make behavioural mistakes during the strategy execution. We show that such an assumption can break a cyclic relationship leading to a stable equilibrium emerging with only one strategy surviving. We consider two cases: completely random mistakes when individuals have no bias towards any strategy and a general form of mistakes. Then, we determine conditions for a strategy to dominate all other strategies. However, given that individuals who adopt a dominating strategy are still prone to behavioural mistakes in the observed behaviour, we may still observe extinct strategies. That is, behavioural mistakes in strategy execution stabilise evolutionary dynamics leading to an evolutionary stable and, potentially, mixed co-existence equilibrium.","lang":"eng"}],"month":"04","intvolume":" 17","scopus_import":"1","file":[{"date_updated":"2021-05-11T13:50:06Z","file_size":1323820,"creator":"kschuh","date_created":"2021-05-11T13:50:06Z","file_name":"2021_pcbi_Kleshnina.pdf","content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"a94ebe0c4116f5047eaa6029e54d2dac","file_id":"9385","success":1}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["1553734X"],"eissn":["15537358"]},"publication_status":"published","volume":17,"issue":"4","ec_funded":1,"_id":"9381","status":"public","type":"journal_article","article_type":"original","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["000"],"date_updated":"2023-08-08T13:31:08Z","file_date_updated":"2021-05-11T13:50:06Z","department":[{"_id":"KrCh"}],"acknowledgement":"Authors would like to thank Christian Hilbe and Martin Nowak for their inspiring and very helpful feedback on the manuscript.","publisher":"Public Library of Science","quality_controlled":"1","oa":1,"day":"01","publication":"PLoS Computational Biology","has_accepted_license":"1","isi":1,"year":"2021","doi":"10.1371/journal.pcbi.1008523","date_published":"2021-04-01T00:00:00Z","date_created":"2021-05-09T22:01:38Z","article_number":"e1008523","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020","name":"Formal Methods for Stochastic Models: Algorithms and Applications","grant_number":"863818"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"mla":"Kleshnina, Maria, et al. “Mistakes Can Stabilise the Dynamics of Rock-Paper-Scissors Games.” PLoS Computational Biology, vol. 17, no. 4, e1008523, Public Library of Science, 2021, doi:10.1371/journal.pcbi.1008523.","short":"M. Kleshnina, S.S. Streipert, J.A. Filar, K. Chatterjee, PLoS Computational Biology 17 (2021).","ieee":"M. Kleshnina, S. S. Streipert, J. A. Filar, and K. Chatterjee, “Mistakes can stabilise the dynamics of rock-paper-scissors games,” PLoS Computational Biology, vol. 17, no. 4. Public Library of Science, 2021.","ama":"Kleshnina M, Streipert SS, Filar JA, Chatterjee K. Mistakes can stabilise the dynamics of rock-paper-scissors games. PLoS Computational Biology. 2021;17(4). doi:10.1371/journal.pcbi.1008523","apa":"Kleshnina, M., Streipert, S. S., Filar, J. A., & Chatterjee, K. (2021). Mistakes can stabilise the dynamics of rock-paper-scissors games. PLoS Computational Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1008523","chicago":"Kleshnina, Maria, Sabrina S. Streipert, Jerzy A. Filar, and Krishnendu Chatterjee. “Mistakes Can Stabilise the Dynamics of Rock-Paper-Scissors Games.” PLoS Computational Biology. Public Library of Science, 2021. https://doi.org/10.1371/journal.pcbi.1008523.","ista":"Kleshnina M, Streipert SS, Filar JA, Chatterjee K. 2021. Mistakes can stabilise the dynamics of rock-paper-scissors games. PLoS Computational Biology. 17(4), e1008523."},"title":"Mistakes can stabilise the dynamics of rock-paper-scissors games","author":[{"id":"4E21749C-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","last_name":"Kleshnina","full_name":"Kleshnina, Maria"},{"last_name":"Streipert","full_name":"Streipert, Sabrina S.","first_name":"Sabrina S."},{"first_name":"Jerzy A.","last_name":"Filar","full_name":"Filar, Jerzy A."},{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee"}],"article_processing_charge":"No","external_id":{"isi":["000639711200001"]}}]