---
_id: '8602'
abstract:
- lang: eng
text: Collective cell migration offers a rich field of study for non-equilibrium
physics and cellular biology, revealing phenomena such as glassy dynamics, pattern
formation and active turbulence. However, how mechanical and chemical signalling
are integrated at the cellular level to give rise to such collective behaviours
remains unclear. We address this by focusing on the highly conserved phenomenon
of spatiotemporal waves of density and extracellular signal-regulated kinase (ERK)
activation, which appear both in vitro and in vivo during collective cell migration
and wound healing. First, we propose a biophysical theory, backed by mechanical
and optogenetic perturbation experiments, showing that patterns can be quantitatively
explained by a mechanochemical coupling between active cellular tensions and the
mechanosensitive ERK pathway. Next, we demonstrate how this biophysical mechanism
can robustly induce long-ranged order and migration in a desired orientation,
and we determine the theoretically optimal wavelength and period for inducing
maximal migration towards free edges, which fits well with experimentally observed
dynamics. We thereby provide a bridge between the biophysical origin of spatiotemporal
instabilities and the design principles of robust and efficient long-ranged migration.
acknowledgement: We would like to thank G. Tkacik and all of the members of the Hannezo
and Hirashima groups for useful discussions, X. Trepat for help on traction force
microscopy and M. Matsuda for use of the lab facility. E.H. acknowledges grants
from the Austrian Science Fund (FWF) (P 31639) and the European Research Council
(851288). T.H. acknowledges a grant from JST, PRESTO (JPMJPR1949). This project
has received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement no. 665385 (to D.B.),
from JSPS KAKENHI grant no. 17J02107 (to N.H.) and from the SPIRITS 2018 of Kyoto
University (to E.H. and T.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Daniel R
full_name: Boocock, Daniel R
id: 453AF628-F248-11E8-B48F-1D18A9856A87
last_name: Boocock
orcid: 0000-0002-1585-2631
- first_name: Naoya
full_name: Hino, Naoya
last_name: Hino
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
- first_name: Tsuyoshi
full_name: Hirashima, Tsuyoshi
last_name: Hirashima
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. Theory of mechanochemical
patterning and optimal migration in cell monolayers. Nature Physics. 2021;17:267-274.
doi:10.1038/s41567-020-01037-7
apa: Boocock, D. R., Hino, N., Ruzickova, N., Hirashima, T., & Hannezo, E. B.
(2021). Theory of mechanochemical patterning and optimal migration in cell monolayers.
Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-020-01037-7
chicago: Boocock, Daniel R, Naoya Hino, Natalia Ruzickova, Tsuyoshi Hirashima, and
Edouard B Hannezo. “Theory of Mechanochemical Patterning and Optimal Migration
in Cell Monolayers.” Nature Physics. Springer Nature, 2021. https://doi.org/10.1038/s41567-020-01037-7.
ieee: D. R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, and E. B. Hannezo, “Theory
of mechanochemical patterning and optimal migration in cell monolayers,” Nature
Physics, vol. 17. Springer Nature, pp. 267–274, 2021.
ista: Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. 2021. Theory of
mechanochemical patterning and optimal migration in cell monolayers. Nature Physics.
17, 267–274.
mla: Boocock, Daniel R., et al. “Theory of Mechanochemical Patterning and Optimal
Migration in Cell Monolayers.” Nature Physics, vol. 17, Springer Nature,
2021, pp. 267–74, doi:10.1038/s41567-020-01037-7.
short: D.R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, E.B. Hannezo, Nature Physics
17 (2021) 267–274.
date_created: 2020-10-04T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2023-08-04T11:02:41Z
day: '01'
department:
- _id: EdHa
doi: 10.1038/s41567-020-01037-7
ec_funded: 1
external_id:
isi:
- '000573519500002'
intvolume: ' 17'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.05.15.096479
month: '02'
oa: 1
oa_version: Preprint
page: 267-274
project:
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Nature Physics
publication_identifier:
eissn:
- '17452481'
issn:
- '17452473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/wound-healing-waves/
record:
- id: '12964'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Theory of mechanochemical patterning and optimal migration in cell monolayers
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2021'
...
---
_id: '8673'
abstract:
- lang: eng
text: In RuCl3, inelastic neutron scattering and Raman spectroscopy reveal a continuum
of non-spin-wave excitations that persists to high temperature, suggesting the
presence of a spin liquid state on a honeycomb lattice. In the context of the
Kitaev model, finite magnetic fields introduce interactions between the elementary
excitations, and thus the effects of high magnetic fields that are comparable
to the spin-exchange energy scale must be explored. Here, we report measurements
of the magnetotropic coefficient—the thermodynamic coefficient associated with
magnetic anisotropy—over a wide range of magnetic fields and temperatures. We
find that magnetic field and temperature compete to determine the magnetic response
in a way that is independent of the large intrinsic exchange-interaction energy.
This emergent scale-invariant magnetic anisotropy provides evidence for a high
degree of exchange frustration that favours the formation of a spin liquid state
in RuCl3.
acknowledgement: We thank M. Baenitz, A. Bangura, R. Coldea, G. Jackeli, S. Kivelson,
S. Nagler, R. Valenti, C. Varma, S. Winter and J. Zaanen for insightful discussions.
Samples were grown at the Max Planck Institute for Chemical Physics of Solids. The
d.c.-field measurements were made at the National High Magnetic Field Laboratory
(NHMFL) in Tallahassee, FL. The pulsed-field measurements were made in the Pulsed
Field Facility of the NHMFL in Los Alamos, NM. All work at the NHMFL is supported
through the National Science Foundation Cooperative Agreement nos. DMR-1157490 and
DMR-1644779, the US Department of Energy and the State of Florida. R.D.M. acknowledges
support from LANL LDRD-DR 20160085 Topology and Strong Correlations. M.C. acknowledges
support from the Department of Energy ‘Science of 100 tesla’ BES programme for high-field
experiments. X-ray data acquisition and analysis was performed at Cornell University.
Research conducted at the Cornell High Energy Synchrotron Source (CHESS) is supported
by the National Science Foundation under award no. DMR-1332208. B.J.R. acknowledges
support from the Institute for Quantum Matter, an Energy Frontier Research Center
funded by the US Department of Energy, Office of Science, Office of Basic Energy
Sciences under award no. DE-SC0019331. Y.L. acknowledges support from the US Department
of Energy through the LANL/LDRD programme and the G.T. Seaborg institute. J.C.P.
is supported by a Gabilan Stanford Graduate Fellowship and an NSF Graduate Research
Fellowship (grant no. DGE-114747). P.J.W.M. acknowledges funding from the Swiss
National Science Foundation through project no. PP00P2-176789.
article_processing_charge: No
article_type: original
author:
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: Ross D.
full_name: McDonald, Ross D.
last_name: McDonald
- first_name: J.P.C.
full_name: Ruff, J.P.C.
last_name: Ruff
- first_name: Maja D.
full_name: Bachmann, Maja D.
last_name: Bachmann
- first_name: You
full_name: Lai, You
last_name: Lai
- first_name: Johanna C.
full_name: Palmstrom, Johanna C.
last_name: Palmstrom
- first_name: David
full_name: Graf, David
last_name: Graf
- first_name: Mun K.
full_name: Chan, Mun K.
last_name: Chan
- first_name: F.F.
full_name: Balakirev, F.F.
last_name: Balakirev
- first_name: J.B.
full_name: Betts, J.B.
last_name: Betts
- first_name: G.S.
full_name: Boebinger, G.S.
last_name: Boebinger
- first_name: Marcus
full_name: Schmidt, Marcus
last_name: Schmidt
- first_name: Michael J.
full_name: Lawler, Michael J.
last_name: Lawler
- first_name: D.A.
full_name: Sokolov, D.A.
last_name: Sokolov
- first_name: Philip J.W.
full_name: Moll, Philip J.W.
last_name: Moll
- first_name: B.J.
full_name: Ramshaw, B.J.
last_name: Ramshaw
- first_name: Arkady
full_name: Shekhter, Arkady
last_name: Shekhter
citation:
ama: Modic KA, McDonald RD, Ruff JPC, et al. Scale-invariant magnetic anisotropy
in RuCl3 at high magnetic fields. Nature Physics. 2021;17:240-244. doi:10.1038/s41567-020-1028-0
apa: Modic, K. A., McDonald, R. D., Ruff, J. P. C., Bachmann, M. D., Lai, Y., Palmstrom,
J. C., … Shekhter, A. (2021). Scale-invariant magnetic anisotropy in RuCl3 at
high magnetic fields. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-020-1028-0
chicago: Modic, Kimberly A, Ross D. McDonald, J.P.C. Ruff, Maja D. Bachmann, You
Lai, Johanna C. Palmstrom, David Graf, et al. “Scale-Invariant Magnetic Anisotropy
in RuCl3 at High Magnetic Fields.” Nature Physics. Springer Nature, 2021.
https://doi.org/10.1038/s41567-020-1028-0.
ieee: K. A. Modic et al., “Scale-invariant magnetic anisotropy in RuCl3 at
high magnetic fields,” Nature Physics, vol. 17. Springer Nature, pp. 240–244,
2021.
ista: Modic KA, McDonald RD, Ruff JPC, Bachmann MD, Lai Y, Palmstrom JC, Graf D,
Chan MK, Balakirev FF, Betts JB, Boebinger GS, Schmidt M, Lawler MJ, Sokolov DA,
Moll PJW, Ramshaw BJ, Shekhter A. 2021. Scale-invariant magnetic anisotropy in
RuCl3 at high magnetic fields. Nature Physics. 17, 240–244.
mla: Modic, Kimberly A., et al. “Scale-Invariant Magnetic Anisotropy in RuCl3 at
High Magnetic Fields.” Nature Physics, vol. 17, Springer Nature, 2021,
pp. 240–44, doi:10.1038/s41567-020-1028-0.
short: K.A. Modic, R.D. McDonald, J.P.C. Ruff, M.D. Bachmann, Y. Lai, J.C. Palmstrom,
D. Graf, M.K. Chan, F.F. Balakirev, J.B. Betts, G.S. Boebinger, M. Schmidt, M.J.
Lawler, D.A. Sokolov, P.J.W. Moll, B.J. Ramshaw, A. Shekhter, Nature Physics 17
(2021) 240–244.
date_created: 2020-10-18T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2023-08-04T11:03:39Z
day: '01'
department:
- _id: KiMo
doi: 10.1038/s41567-020-1028-0
external_id:
arxiv:
- '2005.04228'
isi:
- '000575344700003'
intvolume: ' 17'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.04228
month: '02'
oa: 1
oa_version: Preprint
page: 240-244
publication: Nature Physics
publication_identifier:
eissn:
- '17452481'
issn:
- '17452473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2021'
...
---
_id: '7942'
abstract:
- lang: eng
text: An understanding of the missing antinodal electronic excitations in the pseudogap
state is essential for uncovering the physics of the underdoped cuprate high-temperature
superconductors1,2,3,4,5,6. The majority of high-temperature experiments performed
thus far, however, have been unable to discern whether the antinodal states are
rendered unobservable due to their damping or whether they vanish due to their
gapping7,8,9,10,11,12,13,14,15,16,17,18. Here, we distinguish between these two
scenarios by using quantum oscillations to examine whether the small Fermi surface
pocket, found to occupy only 2% of the Brillouin zone in the underdoped cuprates19,20,21,22,23,24,
exists in isolation against a majority of completely gapped density of states
spanning the antinodes, or whether it is thermodynamically coupled to a background
of ungapped antinodal states. We find that quantum oscillations associated with
the small Fermi surface pocket exhibit a signature sawtooth waveform characteristic
of an isolated two-dimensional Fermi surface pocket25,26,27,28,29,30,31,32. This
finding reveals that the antinodal states are destroyed by a hard gap that extends
over the majority of the Brillouin zone, placing strong constraints on a drastic
underlying origin of quasiparticle disappearance over almost the entire Brillouin
zone in the pseudogap regime7,8,9,10,11,12,13,14,15,16,17,18.
acknowledgement: M.H., Y.-T.H. and S.E.S. acknowledge support from the Royal Society,
the Winton Programme for the Physics of Sustainability, EPSRC (studentship, grant
no. EP/P024947/1 and EPSRC Strategic Equipment grant no. EP/M000524/1) and the European
Research Council (grant no. 772891). S.E.S. acknowledges support from the Leverhulme
Trust by way of the award of a Philip Leverhulme Prize. H.Z., J.W. and Z.Z. acknowledge
support from the National Key Research and Development Program of China (grant no.
2016YFA0401704). A portion of this work was performed at the National High Magnetic
Field Laboratory, which is supported by the National Science Foundation Cooperative
Agreement no. DMR-1644779, the state of Florida and the US Department of Energy.
Work performed by M.K.C., R.D.M. and N.H. was supported by the US DOE BES ‘Science
of 100 T’ programme.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Máté
full_name: Hartstein, Máté
last_name: Hartstein
- first_name: Yu Te
full_name: Hsu, Yu Te
last_name: Hsu
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: Juan
full_name: Porras, Juan
last_name: Porras
- first_name: Toshinao
full_name: Loew, Toshinao
last_name: Loew
- first_name: Matthieu Le
full_name: Tacon, Matthieu Le
last_name: Tacon
- first_name: Huakun
full_name: Zuo, Huakun
last_name: Zuo
- first_name: Jinhua
full_name: Wang, Jinhua
last_name: Wang
- first_name: Zengwei
full_name: Zhu, Zengwei
last_name: Zhu
- first_name: Mun K.
full_name: Chan, Mun K.
last_name: Chan
- first_name: Ross D.
full_name: Mcdonald, Ross D.
last_name: Mcdonald
- first_name: Gilbert G.
full_name: Lonzarich, Gilbert G.
last_name: Lonzarich
- first_name: Bernhard
full_name: Keimer, Bernhard
last_name: Keimer
- first_name: Suchitra E.
full_name: Sebastian, Suchitra E.
last_name: Sebastian
- first_name: Neil
full_name: Harrison, Neil
last_name: Harrison
citation:
ama: Hartstein M, Hsu YT, Modic KA, et al. Hard antinodal gap revealed by quantum
oscillations in the pseudogap regime of underdoped high-Tc superconductors. Nature
Physics. 2020;16:841-847. doi:10.1038/s41567-020-0910-0
apa: Hartstein, M., Hsu, Y. T., Modic, K. A., Porras, J., Loew, T., Tacon, M. L.,
… Harrison, N. (2020). Hard antinodal gap revealed by quantum oscillations in
the pseudogap regime of underdoped high-Tc superconductors. Nature Physics.
Springer Nature. https://doi.org/10.1038/s41567-020-0910-0
chicago: Hartstein, Máté, Yu Te Hsu, Kimberly A Modic, Juan Porras, Toshinao Loew,
Matthieu Le Tacon, Huakun Zuo, et al. “Hard Antinodal Gap Revealed by Quantum
Oscillations in the Pseudogap Regime of Underdoped High-Tc Superconductors.” Nature
Physics. Springer Nature, 2020. https://doi.org/10.1038/s41567-020-0910-0.
ieee: M. Hartstein et al., “Hard antinodal gap revealed by quantum oscillations
in the pseudogap regime of underdoped high-Tc superconductors,” Nature Physics,
vol. 16. Springer Nature, pp. 841–847, 2020.
ista: Hartstein M, Hsu YT, Modic KA, Porras J, Loew T, Tacon ML, Zuo H, Wang J,
Zhu Z, Chan MK, Mcdonald RD, Lonzarich GG, Keimer B, Sebastian SE, Harrison N.
2020. Hard antinodal gap revealed by quantum oscillations in the pseudogap regime
of underdoped high-Tc superconductors. Nature Physics. 16, 841–847.
mla: Hartstein, Máté, et al. “Hard Antinodal Gap Revealed by Quantum Oscillations
in the Pseudogap Regime of Underdoped High-Tc Superconductors.” Nature Physics,
vol. 16, Springer Nature, 2020, pp. 841–47, doi:10.1038/s41567-020-0910-0.
short: M. Hartstein, Y.T. Hsu, K.A. Modic, J. Porras, T. Loew, M.L. Tacon, H. Zuo,
J. Wang, Z. Zhu, M.K. Chan, R.D. Mcdonald, G.G. Lonzarich, B. Keimer, S.E. Sebastian,
N. Harrison, Nature Physics 16 (2020) 841–847.
date_created: 2020-06-07T22:00:56Z
date_published: 2020-08-01T00:00:00Z
date_updated: 2023-08-21T07:06:49Z
day: '01'
department:
- _id: KiMo
doi: 10.1038/s41567-020-0910-0
external_id:
arxiv:
- '2005.14123'
isi:
- '000535464400005'
intvolume: ' 16'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.14123
month: '08'
oa: 1
oa_version: Preprint
page: 841-847
publication: Nature Physics
publication_identifier:
eissn:
- '17452481'
issn:
- '17452473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '9708'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Hard antinodal gap revealed by quantum oscillations in the pseudogap regime
of underdoped high-Tc superconductors
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 16
year: '2020'
...