---
_id: '1359'
abstract:
- lang: eng
text: "The role of gene interactions in the evolutionary process has long\r\nbeen
controversial. Although some argue that they are not of\r\nimportance, because
most variation is additive, others claim that\r\ntheir effect in the long term
can be substantial. Here, we focus on\r\nthe long-term effects of genetic interactions
under directional\r\nselection assuming no mutation or dominance, and that epistasis
is\r\nsymmetrical overall. We ask by how much the mean of a complex\r\ntrait can
be increased by selection and analyze two extreme\r\nregimes, in which either
drift or selection dominate the dynamics\r\nof allele frequencies. In both scenarios,
epistatic interactions affect\r\nthe long-term response to selection by modulating
the additive\r\ngenetic variance. When drift dominates, we extend Robertson\r\n’\r\ns\r\n[Robertson
A (1960)\r\nProc R Soc Lond B Biol Sci\r\n153(951):234\r\n−\r\n249]\r\nargument
to show that, for any form of epistasis, the total response\r\nof a haploid population
is proportional to the initial total genotypic\r\nvariance. In contrast, the total
response of a diploid population is\r\nincreased by epistasis, for a given initial
genotypic variance. When\r\nselection dominates, we show that the total selection
response can\r\nonly be increased by epistasis when s\r\nome initially deleterious
alleles\r\nbecome favored as the genetic background changes. We find a sim-\r\nple
approximation for this effect and show that, in this regime, it is\r\nthe structure
of the genotype - phenotype map that matters and not\r\nthe variance components
of the population."
article_processing_charge: No
article_type: original
author:
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Paixao T, Barton NH. The effect of gene interactions on the long-term response
to selection. PNAS. 2016;113(16):4422-4427. doi:10.1073/pnas.1518830113
apa: Paixao, T., & Barton, N. H. (2016). The effect of gene interactions on
the long-term response to selection. PNAS. National Academy of Sciences.
https://doi.org/10.1073/pnas.1518830113
chicago: Paixao, Tiago, and Nicholas H Barton. “The Effect of Gene Interactions
on the Long-Term Response to Selection.” PNAS. National Academy of Sciences,
2016. https://doi.org/10.1073/pnas.1518830113.
ieee: T. Paixao and N. H. Barton, “The effect of gene interactions on the long-term
response to selection,” PNAS, vol. 113, no. 16. National Academy of Sciences,
pp. 4422–4427, 2016.
ista: Paixao T, Barton NH. 2016. The effect of gene interactions on the long-term
response to selection. PNAS. 113(16), 4422–4427.
mla: Paixao, Tiago, and Nicholas H. Barton. “The Effect of Gene Interactions on
the Long-Term Response to Selection.” PNAS, vol. 113, no. 16, National
Academy of Sciences, 2016, pp. 4422–27, doi:10.1073/pnas.1518830113.
short: T. Paixao, N.H. Barton, PNAS 113 (2016) 4422–4427.
date_created: 2018-12-11T11:51:34Z
date_published: 2016-04-19T00:00:00Z
date_updated: 2021-01-12T06:50:08Z
day: '19'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1073/pnas.1518830113
ec_funded: 1
external_id:
pmid:
- '27044080'
intvolume: ' 113'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843425/
month: '04'
oa: 1
oa_version: Published Version
page: 4422 - 4427
pmid: 1
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618091'
name: Speed of Adaptation in Population Genetics and Evolutionary Computation
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5886'
quality_controlled: '1'
scopus_import: 1
status: public
title: The effect of gene interactions on the long-term response to selection
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 113
year: '2016'
...
---
_id: '1356'
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Sewall Wright on evolution in Mendelian populations and the “Shifting
Balance.” Genetics. 2016;202(1):3-4. doi:10.1534/genetics.115.184796
apa: Barton, N. H. (2016). Sewall Wright on evolution in Mendelian populations and
the “Shifting Balance.” Genetics. Genetics Society of America. https://doi.org/10.1534/genetics.115.184796
chicago: Barton, Nicholas H. “Sewall Wright on Evolution in Mendelian Populations
and the ‘Shifting Balance.’” Genetics. Genetics Society of America, 2016.
https://doi.org/10.1534/genetics.115.184796.
ieee: N. H. Barton, “Sewall Wright on evolution in Mendelian populations and the
‘Shifting Balance,’” Genetics, vol. 202, no. 1. Genetics Society of America,
pp. 3–4, 2016.
ista: Barton NH. 2016. Sewall Wright on evolution in Mendelian populations and the
“Shifting Balance”. Genetics. 202(1), 3–4.
mla: Barton, Nicholas H. “Sewall Wright on Evolution in Mendelian Populations and
the ‘Shifting Balance.’” Genetics, vol. 202, no. 1, Genetics Society of
America, 2016, pp. 3–4, doi:10.1534/genetics.115.184796.
short: N.H. Barton, Genetics 202 (2016) 3–4.
date_created: 2018-12-11T11:51:33Z
date_published: 2016-01-05T00:00:00Z
date_updated: 2021-01-12T06:50:07Z
day: '05'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1534/genetics.115.184796
file:
- access_level: open_access
checksum: 3562b89c821a4be84edf2b6ebd870cf5
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:26Z
date_updated: 2020-07-14T12:44:46Z
file_id: '4687'
file_name: IST-2017-769-v1+1_SewallWright1931.pdf
file_size: 112674
relation: main_file
file_date_updated: 2020-07-14T12:44:46Z
has_accepted_license: '1'
intvolume: ' 202'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 3 - 4
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '5889'
pubrep_id: '769'
quality_controlled: '1'
scopus_import: 1
status: public
title: Sewall Wright on evolution in Mendelian populations and the “Shifting Balance”
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 202
year: '2016'
...
---
_id: '1357'
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Richard Hudson and Norman Kaplan on the coalescent process. Genetics.
2016;202(3):865-866. doi:10.1534/genetics.116.187542
apa: Barton, N. H. (2016). Richard Hudson and Norman Kaplan on the coalescent process.
Genetics. Genetics Society of America. https://doi.org/10.1534/genetics.116.187542
chicago: Barton, Nicholas H. “Richard Hudson and Norman Kaplan on the Coalescent
Process.” Genetics. Genetics Society of America, 2016. https://doi.org/10.1534/genetics.116.187542.
ieee: N. H. Barton, “Richard Hudson and Norman Kaplan on the coalescent process,”
Genetics, vol. 202, no. 3. Genetics Society of America, pp. 865–866, 2016.
ista: Barton NH. 2016. Richard Hudson and Norman Kaplan on the coalescent process.
Genetics. 202(3), 865–866.
mla: Barton, Nicholas H. “Richard Hudson and Norman Kaplan on the Coalescent Process.”
Genetics, vol. 202, no. 3, Genetics Society of America, 2016, pp. 865–66,
doi:10.1534/genetics.116.187542.
short: N.H. Barton, Genetics 202 (2016) 865–866.
date_created: 2018-12-11T11:51:33Z
date_published: 2016-03-01T00:00:00Z
date_updated: 2021-01-12T06:50:07Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1534/genetics.116.187542
file:
- access_level: open_access
checksum: b2174bab2de1d1142900062a150f35c9
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:09Z
date_updated: 2020-07-14T12:44:46Z
file_id: '5127'
file_name: IST-2017-768-v1+1_Hudson-Kaplan-1988.pdf
file_size: 130779
relation: main_file
file_date_updated: 2020-07-14T12:44:46Z
has_accepted_license: '1'
intvolume: ' 202'
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 865 - 866
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '5888'
pubrep_id: '768'
quality_controlled: '1'
scopus_import: 1
status: public
title: Richard Hudson and Norman Kaplan on the coalescent process
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 202
year: '2016'
...
---
_id: '1409'
author:
- first_name: Richard
full_name: Abbott, Richard
last_name: Abbott
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Jeffrey
full_name: Good, Jeffrey
last_name: Good
citation:
ama: Abbott R, Barton NH, Good J. Genomics of hybridization and its evolutionary
consequences. Molecular Ecology. 2016;25(11):2325-2332. doi:10.1111/mec.13685
apa: Abbott, R., Barton, N. H., & Good, J. (2016). Genomics of hybridization
and its evolutionary consequences. Molecular Ecology. Wiley-Blackwell.
https://doi.org/10.1111/mec.13685
chicago: Abbott, Richard, Nicholas H Barton, and Jeffrey Good. “Genomics of Hybridization
and Its Evolutionary Consequences.” Molecular Ecology. Wiley-Blackwell,
2016. https://doi.org/10.1111/mec.13685.
ieee: R. Abbott, N. H. Barton, and J. Good, “Genomics of hybridization and its evolutionary
consequences,” Molecular Ecology, vol. 25, no. 11. Wiley-Blackwell, pp.
2325–2332, 2016.
ista: Abbott R, Barton NH, Good J. 2016. Genomics of hybridization and its evolutionary
consequences. Molecular Ecology. 25(11), 2325–2332.
mla: Abbott, Richard, et al. “Genomics of Hybridization and Its Evolutionary Consequences.”
Molecular Ecology, vol. 25, no. 11, Wiley-Blackwell, 2016, pp. 2325–32,
doi:10.1111/mec.13685.
short: R. Abbott, N.H. Barton, J. Good, Molecular Ecology 25 (2016) 2325–2332.
date_created: 2018-12-11T11:51:51Z
date_published: 2016-06-08T00:00:00Z
date_updated: 2021-01-12T06:50:33Z
day: '08'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1111/mec.13685
file:
- access_level: open_access
checksum: ede7d0b8a471754f71f17e2b20f3135b
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:12Z
date_updated: 2020-07-14T12:44:53Z
file_id: '4797'
file_name: IST-2017-772-v1+1_AbbotEtAl2016-3.pdf
file_size: 226137
relation: main_file
file_date_updated: 2020-07-14T12:44:53Z
has_accepted_license: '1'
intvolume: ' 25'
issue: '11'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 2325 - 2332
publication: Molecular Ecology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5798'
pubrep_id: '772'
quality_controlled: '1'
scopus_import: 1
status: public
title: Genomics of hybridization and its evolutionary consequences
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2016'
...
---
_id: '1420'
abstract:
- lang: eng
text: 'Selection, mutation, and random drift affect the dynamics of allele frequencies
and consequently of quantitative traits. While the macroscopic dynamics of quantitative
traits can be measured, the underlying allele frequencies are typically unobserved.
Can we understand how the macroscopic observables evolve without following these
microscopic processes? This problem has been studied previously by analogy with
statistical mechanics: the allele frequency distribution at each time point is
approximated by the stationary form, which maximizes entropy. We explore the limitations
of this method when mutation is small (4Nμ < 1) so that populations are typically
close to fixation, and we extend the theory in this regime to account for changes
in mutation strength. We consider a single diallelic locus either under directional
selection or with overdominance and then generalize to multiple unlinked biallelic
loci with unequal effects. We find that the maximum-entropy approximation is remarkably
accurate, even when mutation and selection change rapidly. '
article_processing_charge: No
author:
- first_name: Katarína
full_name: Bod'ová, Katarína
id: 2BA24EA0-F248-11E8-B48F-1D18A9856A87
last_name: Bod'ová
orcid: 0000-0002-7214-0171
- first_name: Gasper
full_name: Tkacik, Gasper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkacik
orcid: 0000-0002-6699-1455
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Bodova K, Tkačik G, Barton NH. A general approximation for the dynamics of
quantitative traits. Genetics. 2016;202(4):1523-1548. doi:10.1534/genetics.115.184127
apa: Bodova, K., Tkačik, G., & Barton, N. H. (2016). A general approximation
for the dynamics of quantitative traits. Genetics. Genetics Society of
America. https://doi.org/10.1534/genetics.115.184127
chicago: Bodova, Katarina, Gašper Tkačik, and Nicholas H Barton. “A General Approximation
for the Dynamics of Quantitative Traits.” Genetics. Genetics Society of
America, 2016. https://doi.org/10.1534/genetics.115.184127.
ieee: K. Bodova, G. Tkačik, and N. H. Barton, “A general approximation for the dynamics
of quantitative traits,” Genetics, vol. 202, no. 4. Genetics Society of
America, pp. 1523–1548, 2016.
ista: Bodova K, Tkačik G, Barton NH. 2016. A general approximation for the dynamics
of quantitative traits. Genetics. 202(4), 1523–1548.
mla: Bodova, Katarina, et al. “A General Approximation for the Dynamics of Quantitative
Traits.” Genetics, vol. 202, no. 4, Genetics Society of America, 2016,
pp. 1523–48, doi:10.1534/genetics.115.184127.
short: K. Bodova, G. Tkačik, N.H. Barton, Genetics 202 (2016) 1523–1548.
date_created: 2018-12-11T11:51:55Z
date_published: 2016-04-06T00:00:00Z
date_updated: 2022-08-01T10:49:55Z
day: '06'
department:
- _id: GaTk
- _id: NiBa
doi: 10.1534/genetics.115.184127
ec_funded: 1
external_id:
arxiv:
- '1510.08344'
intvolume: ' 202'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1510.08344
month: '04'
oa: 1
oa_version: Preprint
page: 1523 - 1548
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
- _id: 255008E4-B435-11E9-9278-68D0E5697425
grant_number: RGP0065/2012
name: Information processing and computation in fish groups
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '5787'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A general approximation for the dynamics of quantitative traits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 202
year: '2016'
...