[{"type":"journal_article","abstract":[{"text":"The immune response relies on the migration of leukocytes and on their ability to stop in precise anatomical locations to fulfil their task. How leukocyte migration and function are coordinated is unknown. Here we show that in immature dendritic cells, which patrol their environment by engulfing extracellular material, cell migration and antigen capture are antagonistic. This antagonism results from transient enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting antigen capture. We further highlight that myosin IIA enrichment at the cell front requires the MHC class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization, Ii imposes on dendritic cells an intermittent antigen capture behaviour that might facilitate environment patrolling. We propose that the requirement for myosin II in both cell migration and specific cell functions may provide a general mechanism for their coordination in time and space.","lang":"eng"}],"_id":"1575","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells","status":"public","ddc":["570"],"intvolume":" 6","pubrep_id":"476","file":[{"file_name":"IST-2016-476-v1+1_ncomms8526.pdf","access_level":"open_access","creator":"system","file_size":4530215,"content_type":"application/pdf","file_id":"4915","relation":"main_file","date_created":"2018-12-12T10:11:58Z","date_updated":"2020-07-14T12:45:02Z","checksum":"bae12e86be2adb28253f890b8bba8315"}],"oa_version":"Published Version","scopus_import":1,"day":"25","has_accepted_license":"1","publication":"Nature Communications","citation":{"mla":"Chabaud, Mélanie, et al. “Cell Migration and Antigen Capture Are Antagonistic Processes Coupled by Myosin II in Dendritic Cells.” Nature Communications, vol. 6, 7526, Nature Publishing Group, 2015, doi:10.1038/ncomms8526.","short":"M. Chabaud, M. Heuzé, M. Bretou, P. Vargas, P. Maiuri, P. Solanes, M. Maurin, E. Terriac, M. Le Berre, D. Lankar, T. Piolot, R. Adelstein, Y. Zhang, M.K. Sixt, J. Jacobelli, O. Bénichou, R. Voituriez, M. Piel, A. Lennon Duménil, Nature Communications 6 (2015).","chicago":"Chabaud, Mélanie, Mélina Heuzé, Marine Bretou, Pablo Vargas, Paolo Maiuri, Paola Solanes, Mathieu Maurin, et al. “Cell Migration and Antigen Capture Are Antagonistic Processes Coupled by Myosin II in Dendritic Cells.” Nature Communications. Nature Publishing Group, 2015. https://doi.org/10.1038/ncomms8526.","ama":"Chabaud M, Heuzé M, Bretou M, et al. Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nature Communications. 2015;6. doi:10.1038/ncomms8526","ista":"Chabaud M, Heuzé M, Bretou M, Vargas P, Maiuri P, Solanes P, Maurin M, Terriac E, Le Berre M, Lankar D, Piolot T, Adelstein R, Zhang Y, Sixt MK, Jacobelli J, Bénichou O, Voituriez R, Piel M, Lennon Duménil A. 2015. Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nature Communications. 6, 7526.","apa":"Chabaud, M., Heuzé, M., Bretou, M., Vargas, P., Maiuri, P., Solanes, P., … Lennon Duménil, A. (2015). Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms8526","ieee":"M. Chabaud et al., “Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells,” Nature Communications, vol. 6. Nature Publishing Group, 2015."},"date_published":"2015-06-25T00:00:00Z","article_number":"7526","file_date_updated":"2020-07-14T12:45:02Z","publist_id":"5596","license":"https://creativecommons.org/licenses/by/4.0/","year":"2015","acknowledgement":"M.C. and M.L.H. were supported by fellowships from the Fondation pour la Recherche Médicale and the Association pour la Recherche contre le Cancer, respectively. This work was funded by grants from the City of Paris and the European Research Council to A.-M.L.-D. (Strapacemi 243103), the Association Nationale pour la Recherche (ANR-09-PIRI-0027-PCVI) and the InnaBiosanté foundation (Micemico) to A.-M.L.-D., M.P. and R.V., and the DCBIOL Labex from the French Government (ANR-10-IDEX-0001-02-PSL* and ANR-11-LABX-0043). The super-resolution SIM microscope was funded through an ERC Advanced Investigator Grant (250367) to Edith Heard (CNRS UMR3215/Inserm U934, Institut Curie).","publication_status":"published","publisher":"Nature Publishing Group","department":[{"_id":"MiSi"}],"author":[{"full_name":"Chabaud, Mélanie","first_name":"Mélanie","last_name":"Chabaud"},{"full_name":"Heuzé, Mélina","last_name":"Heuzé","first_name":"Mélina"},{"first_name":"Marine","last_name":"Bretou","full_name":"Bretou, Marine"},{"last_name":"Vargas","first_name":"Pablo","full_name":"Vargas, Pablo"},{"last_name":"Maiuri","first_name":"Paolo","full_name":"Maiuri, Paolo"},{"last_name":"Solanes","first_name":"Paola","full_name":"Solanes, Paola"},{"full_name":"Maurin, Mathieu","last_name":"Maurin","first_name":"Mathieu"},{"last_name":"Terriac","first_name":"Emmanuel","full_name":"Terriac, Emmanuel"},{"full_name":"Le Berre, Maël","first_name":"Maël","last_name":"Le Berre"},{"full_name":"Lankar, Danielle","last_name":"Lankar","first_name":"Danielle"},{"full_name":"Piolot, Tristan","last_name":"Piolot","first_name":"Tristan"},{"full_name":"Adelstein, Robert","last_name":"Adelstein","first_name":"Robert"},{"full_name":"Zhang, Yingfan","last_name":"Zhang","first_name":"Yingfan"},{"full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","first_name":"Michael K"},{"last_name":"Jacobelli","first_name":"Jordan","full_name":"Jacobelli, Jordan"},{"first_name":"Olivier","last_name":"Bénichou","full_name":"Bénichou, Olivier"},{"full_name":"Voituriez, Raphaël","last_name":"Voituriez","first_name":"Raphaël"},{"first_name":"Matthieu","last_name":"Piel","full_name":"Piel, Matthieu"},{"full_name":"Lennon Duménil, Ana","last_name":"Lennon Duménil","first_name":"Ana"}],"date_updated":"2021-01-12T06:51:42Z","date_created":"2018-12-11T11:52:48Z","volume":6,"month":"06","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"quality_controlled":"1","doi":"10.1038/ncomms8526","language":[{"iso":"eng"}]},{"scopus_import":1,"month":"10","day":"01","citation":{"chicago":"Sixt, Michael K, and Erez Raz. “Editorial Overview: Cell Adhesion and Migration.” Current Opinion in Cell Biology. Elsevier, 2015. https://doi.org/10.1016/j.ceb.2015.09.004.","short":"M.K. Sixt, E. Raz, Current Opinion in Cell Biology 36 (2015) 4–6.","mla":"Sixt, Michael K., and Erez Raz. “Editorial Overview: Cell Adhesion and Migration.” Current Opinion in Cell Biology, vol. 36, no. 10, Elsevier, 2015, pp. 4–6, doi:10.1016/j.ceb.2015.09.004.","apa":"Sixt, M. K., & Raz, E. (2015). Editorial overview: Cell adhesion and migration. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2015.09.004","ieee":"M. K. Sixt and E. Raz, “Editorial overview: Cell adhesion and migration,” Current Opinion in Cell Biology, vol. 36, no. 10. Elsevier, pp. 4–6, 2015.","ista":"Sixt MK, Raz E. 2015. Editorial overview: Cell adhesion and migration. Current Opinion in Cell Biology. 36(10), 4–6.","ama":"Sixt MK, Raz E. Editorial overview: Cell adhesion and migration. Current Opinion in Cell Biology. 2015;36(10):4-6. doi:10.1016/j.ceb.2015.09.004"},"publication":"Current Opinion in Cell Biology","page":"4 - 6","date_published":"2015-10-01T00:00:00Z","doi":"10.1016/j.ceb.2015.09.004","language":[{"iso":"eng"}],"type":"journal_article","publist_id":"5473","issue":"10","_id":"1676","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2015","intvolume":" 36","publisher":"Elsevier","department":[{"_id":"MiSi"}],"publication_status":"published","status":"public","title":"Editorial overview: Cell adhesion and migration","author":[{"full_name":"Sixt, Michael K","last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Raz, Erez","first_name":"Erez","last_name":"Raz"}],"volume":36,"oa_version":"None","date_updated":"2021-01-12T06:52:27Z","date_created":"2018-12-11T11:53:25Z"},{"volume":36,"date_created":"2018-12-11T11:53:28Z","date_updated":"2021-01-12T06:52:31Z","author":[{"first_name":"Milka","last_name":"Sarris","full_name":"Sarris, Milka"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","full_name":"Sixt, Michael K"}],"publisher":"Elsevier","department":[{"_id":"MiSi"}],"publication_status":"published","year":"2015","publist_id":"5458","ec_funded":1,"file_date_updated":"2020-07-14T12:45:12Z","language":[{"iso":"eng"}],"doi":"10.1016/j.ceb.2015.08.001","project":[{"grant_number":"281556","_id":"25A603A2-B435-11E9-9278-68D0E5697425","name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)","call_identifier":"FP7"}],"quality_controlled":"1","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"month":"10","oa_version":"Published Version","file":[{"file_id":"4875","relation":"main_file","checksum":"c29973924b790aab02fdd91857759cfb","date_updated":"2020-07-14T12:45:12Z","date_created":"2018-12-12T10:11:21Z","access_level":"open_access","file_name":"IST-2016-445-v1+1_1-s2.0-S0955067415001064-main.pdf","creator":"system","file_size":797964,"content_type":"application/pdf"}],"pubrep_id":"445","intvolume":" 36","ddc":["570"],"title":"Navigating in tissue mazes: Chemoattractant interpretation in complex environments","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"1687","issue":"10","abstract":[{"lang":"eng","text":"Guided cell movement is essential for development and integrity of animals and crucially involved in cellular immune responses. Leukocytes are professional migratory cells that can navigate through most types of tissues and sense a wide range of directional cues. The responses of these cells to attractants have been mainly explored in tissue culture settings. How leukocytes make directional decisions in situ, within the challenging environment of a tissue maze, is less understood. Here we review recent advances in how leukocytes sense chemical cues in complex tissue settings and make links with paradigms of directed migration in development and Dictyostelium discoideum amoebae."}],"type":"journal_article","date_published":"2015-10-01T00:00:00Z","page":"93 - 102","citation":{"mla":"Sarris, Milka, and Michael K. Sixt. “Navigating in Tissue Mazes: Chemoattractant Interpretation in Complex Environments.” Current Opinion in Cell Biology, vol. 36, no. 10, Elsevier, 2015, pp. 93–102, doi:10.1016/j.ceb.2015.08.001.","short":"M. Sarris, M.K. Sixt, Current Opinion in Cell Biology 36 (2015) 93–102.","chicago":"Sarris, Milka, and Michael K Sixt. “Navigating in Tissue Mazes: Chemoattractant Interpretation in Complex Environments.” Current Opinion in Cell Biology. Elsevier, 2015. https://doi.org/10.1016/j.ceb.2015.08.001.","ama":"Sarris M, Sixt MK. Navigating in tissue mazes: Chemoattractant interpretation in complex environments. Current Opinion in Cell Biology. 2015;36(10):93-102. doi:10.1016/j.ceb.2015.08.001","ista":"Sarris M, Sixt MK. 2015. Navigating in tissue mazes: Chemoattractant interpretation in complex environments. Current Opinion in Cell Biology. 36(10), 93–102.","apa":"Sarris, M., & Sixt, M. K. (2015). Navigating in tissue mazes: Chemoattractant interpretation in complex environments. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2015.08.001","ieee":"M. Sarris and M. K. Sixt, “Navigating in tissue mazes: Chemoattractant interpretation in complex environments,” Current Opinion in Cell Biology, vol. 36, no. 10. Elsevier, pp. 93–102, 2015."},"publication":"Current Opinion in Cell Biology","has_accepted_license":"1","day":"01","scopus_import":1},{"month":"09","day":"04","scopus_import":1,"date_published":"2015-09-04T00:00:00Z","doi":"10.1126/science.aad0867","language":[{"iso":"eng"}],"publication":"Science","citation":{"chicago":"Kiermaier, Eva, and Michael K Sixt. “Fragmented Communication between Immune Cells: Neutrophils Blaze a Trail with Migratory Cues for T Cells to Follow to Sites of Infection.” Science. American Association for the Advancement of Science, 2015. https://doi.org/10.1126/science.aad0867.","mla":"Kiermaier, Eva, and Michael K. Sixt. “Fragmented Communication between Immune Cells: Neutrophils Blaze a Trail with Migratory Cues for T Cells to Follow to Sites of Infection.” Science, vol. 349, no. 6252, American Association for the Advancement of Science, 2015, pp. 1055–56, doi:10.1126/science.aad0867.","short":"E. Kiermaier, M.K. Sixt, Science 349 (2015) 1055–1056.","ista":"Kiermaier E, Sixt MK. 2015. Fragmented communication between immune cells: Neutrophils blaze a trail with migratory cues for T cells to follow to sites of infection. Science. 349(6252), 1055–1056.","apa":"Kiermaier, E., & Sixt, M. K. (2015). Fragmented communication between immune cells: Neutrophils blaze a trail with migratory cues for T cells to follow to sites of infection. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aad0867","ieee":"E. Kiermaier and M. K. Sixt, “Fragmented communication between immune cells: Neutrophils blaze a trail with migratory cues for T cells to follow to sites of infection,” Science, vol. 349, no. 6252. American Association for the Advancement of Science, pp. 1055–1056, 2015.","ama":"Kiermaier E, Sixt MK. Fragmented communication between immune cells: Neutrophils blaze a trail with migratory cues for T cells to follow to sites of infection. Science. 2015;349(6252):1055-1056. doi:10.1126/science.aad0867"},"quality_controlled":"1","page":"1055 - 1056","issue":"6252","publist_id":"5459","type":"journal_article","author":[{"id":"3EB04B78-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6165-5738","first_name":"Eva","last_name":"Kiermaier","full_name":"Kiermaier, Eva"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","full_name":"Sixt, Michael K"}],"date_created":"2018-12-11T11:53:28Z","date_updated":"2021-01-12T06:52:31Z","oa_version":"None","volume":349,"year":"2015","_id":"1686","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","publication_status":"published","title":"Fragmented communication between immune cells: Neutrophils blaze a trail with migratory cues for T cells to follow to sites of infection","department":[{"_id":"MiSi"}],"publisher":"American Association for the Advancement of Science","intvolume":" 349"},{"scopus_import":1,"month":"06","day":"15","citation":{"chicago":"Holst, Katrin, Daria Guseva, Susann Schindler, Michael K Sixt, Armin Braun, Himpriya Chopra, Oliver Pabst, and Evgeni Ponimaskin. “The Serotonin Receptor 5-HT7R Regulates the Morphology and Migratory Properties of Dendritic Cells.” Journal of Cell Science. Company of Biologists, 2015. https://doi.org/10.1242/jcs.167999.","short":"K. Holst, D. Guseva, S. Schindler, M.K. Sixt, A. Braun, H. Chopra, O. Pabst, E. Ponimaskin, Journal of Cell Science 128 (2015) 2866–2880.","mla":"Holst, Katrin, et al. “The Serotonin Receptor 5-HT7R Regulates the Morphology and Migratory Properties of Dendritic Cells.” Journal of Cell Science, vol. 128, no. 15, Company of Biologists, 2015, pp. 2866–80, doi:10.1242/jcs.167999.","ieee":"K. Holst et al., “The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells,” Journal of Cell Science, vol. 128, no. 15. Company of Biologists, pp. 2866–2880, 2015.","apa":"Holst, K., Guseva, D., Schindler, S., Sixt, M. K., Braun, A., Chopra, H., … Ponimaskin, E. (2015). The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells. Journal of Cell Science. Company of Biologists. https://doi.org/10.1242/jcs.167999","ista":"Holst K, Guseva D, Schindler S, Sixt MK, Braun A, Chopra H, Pabst O, Ponimaskin E. 2015. The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells. Journal of Cell Science. 128(15), 2866–2880.","ama":"Holst K, Guseva D, Schindler S, et al. The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells. Journal of Cell Science. 2015;128(15):2866-2880. doi:10.1242/jcs.167999"},"publication":"Journal of Cell Science","page":"2866 - 2880","quality_controlled":"1","date_published":"2015-06-15T00:00:00Z","doi":"10.1242/jcs.167999","language":[{"iso":"eng"}],"type":"journal_article","issue":"15","publist_id":"7343","abstract":[{"text":"Dendritic cells are potent antigen-presenting cells endowed with the unique ability to initiate adaptive immune responses upon inflammation. Inflammatory processes are often associated with an increased production of serotonin, which operates by activating specific receptors. However, the functional role of serotonin receptors in regulation of dendritic cell functions is poorly understood. Here, we demonstrate that expression of serotonin receptor 5-HT7 (5-HT7TR) as well as its downstream effector Cdc42 is upregulated in dendritic cells upon maturation. Although dendritic cell maturation was independent of 5-HT7TR, receptor stimulation affected dendritic cell morphology through Cdc42-mediated signaling. In addition, basal activity of 5-HT7TR was required for the proper expression of the chemokine receptor CCR7, which is a key factor that controls dendritic cell migration. Consistent with this, we observed that 5-HT7TR enhances chemotactic motility of dendritic cells in vitro by modulating their directionality and migration velocity. Accordingly, migration of dendritic cells in murine colon explants was abolished after pharmacological receptor inhibition. Our results indicate that there is a crucial role for 5-HT7TR-Cdc42-mediated signaling in the regulation of dendritic cell morphology and motility, suggesting that 5-HT7TR could be a new target for treatment of a variety of inflammatory and immune disorders.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"477","year":"2015","publisher":"Company of Biologists","department":[{"_id":"MiSi"}],"intvolume":" 128","title":"The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells","status":"public","publication_status":"published","author":[{"full_name":"Holst, Katrin","first_name":"Katrin","last_name":"Holst"},{"last_name":"Guseva","first_name":"Daria","full_name":"Guseva, Daria"},{"full_name":"Schindler, Susann","first_name":"Susann","last_name":"Schindler"},{"full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt"},{"full_name":"Braun, Armin","last_name":"Braun","first_name":"Armin"},{"first_name":"Himpriya","last_name":"Chopra","full_name":"Chopra, Himpriya"},{"full_name":"Pabst, Oliver","first_name":"Oliver","last_name":"Pabst"},{"first_name":"Evgeni","last_name":"Ponimaskin","full_name":"Ponimaskin, Evgeni"}],"volume":128,"oa_version":"None","date_created":"2018-12-11T11:46:41Z","date_updated":"2021-01-12T08:00:54Z"},{"quality_controlled":"1","project":[{"grant_number":"281556","_id":"25A603A2-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)"}],"external_id":{"pmid":["26115234"]},"oa":1,"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809050/"}],"language":[{"iso":"eng"}],"doi":"10.1021/acs.biochem.5b00560","month":"06","publication_status":"published","department":[{"_id":"MiSi"}],"publisher":"American Chemical Society","year":"2015","pmid":1,"date_created":"2018-12-11T11:53:03Z","date_updated":"2023-03-30T11:32:57Z","volume":54,"author":[{"last_name":"Veldkamp","first_name":"Christopher","full_name":"Veldkamp, Christopher"},{"last_name":"Kiermaier","first_name":"Eva","orcid":"0000-0001-6165-5738","id":"3EB04B78-F248-11E8-B48F-1D18A9856A87","full_name":"Kiermaier, Eva"},{"last_name":"Gabel Eissens","first_name":"Skylar","full_name":"Gabel Eissens, Skylar"},{"full_name":"Gillitzer, Miranda","last_name":"Gillitzer","first_name":"Miranda"},{"last_name":"Lippner","first_name":"David","full_name":"Lippner, David"},{"full_name":"Disilvio, Frank","first_name":"Frank","last_name":"Disilvio"},{"full_name":"Mueller, Casey","first_name":"Casey","last_name":"Mueller"},{"full_name":"Wantuch, Paeton","first_name":"Paeton","last_name":"Wantuch"},{"full_name":"Chaffee, Gary","last_name":"Chaffee","first_name":"Gary"},{"full_name":"Famiglietti, Michael","last_name":"Famiglietti","first_name":"Michael"},{"last_name":"Zgoba","first_name":"Danielle","full_name":"Zgoba, Danielle"},{"full_name":"Bailey, Asha","first_name":"Asha","last_name":"Bailey"},{"full_name":"Bah, Yaya","last_name":"Bah","first_name":"Yaya"},{"full_name":"Engebretson, Samantha","last_name":"Engebretson","first_name":"Samantha"},{"full_name":"Graupner, David","last_name":"Graupner","first_name":"David"},{"last_name":"Lackner","first_name":"Emily","full_name":"Lackner, Emily"},{"full_name":"Larosa, Vincent","last_name":"Larosa","first_name":"Vincent"},{"last_name":"Medeiros","first_name":"Tysha","full_name":"Medeiros, Tysha"},{"full_name":"Olson, Michael","last_name":"Olson","first_name":"Michael"},{"full_name":"Phillips, Andrew","last_name":"Phillips","first_name":"Andrew"},{"full_name":"Pyles, Harley","first_name":"Harley","last_name":"Pyles"},{"full_name":"Richard, Amanda","last_name":"Richard","first_name":"Amanda"},{"full_name":"Schoeller, Scott","first_name":"Scott","last_name":"Schoeller"},{"last_name":"Touzeau","first_name":"Boris","full_name":"Touzeau, Boris"},{"first_name":"Larry","last_name":"Williams","full_name":"Williams, Larry"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","full_name":"Sixt, Michael K"},{"last_name":"Peterson","first_name":"Francis","full_name":"Peterson, Francis"}],"ec_funded":1,"publist_id":"5548","page":"4163 - 4166","publication":"Biochemistry","citation":{"chicago":"Veldkamp, Christopher, Eva Kiermaier, Skylar Gabel Eissens, Miranda Gillitzer, David Lippner, Frank Disilvio, Casey Mueller, et al. “Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.” Biochemistry. American Chemical Society, 2015. https://doi.org/10.1021/acs.biochem.5b00560.","short":"C. Veldkamp, E. Kiermaier, S. Gabel Eissens, M. Gillitzer, D. Lippner, F. Disilvio, C. Mueller, P. Wantuch, G. Chaffee, M. Famiglietti, D. Zgoba, A. Bailey, Y. Bah, S. Engebretson, D. Graupner, E. Lackner, V. Larosa, T. Medeiros, M. Olson, A. Phillips, H. Pyles, A. Richard, S. Schoeller, B. Touzeau, L. Williams, M.K. Sixt, F. Peterson, Biochemistry 54 (2015) 4163–4166.","mla":"Veldkamp, Christopher, et al. “Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.” Biochemistry, vol. 54, no. 27, American Chemical Society, 2015, pp. 4163–66, doi:10.1021/acs.biochem.5b00560.","apa":"Veldkamp, C., Kiermaier, E., Gabel Eissens, S., Gillitzer, M., Lippner, D., Disilvio, F., … Peterson, F. (2015). Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites. Biochemistry. American Chemical Society. https://doi.org/10.1021/acs.biochem.5b00560","ieee":"C. Veldkamp et al., “Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites,” Biochemistry, vol. 54, no. 27. American Chemical Society, pp. 4163–4166, 2015.","ista":"Veldkamp C, Kiermaier E, Gabel Eissens S, Gillitzer M, Lippner D, Disilvio F, Mueller C, Wantuch P, Chaffee G, Famiglietti M, Zgoba D, Bailey A, Bah Y, Engebretson S, Graupner D, Lackner E, Larosa V, Medeiros T, Olson M, Phillips A, Pyles H, Richard A, Schoeller S, Touzeau B, Williams L, Sixt MK, Peterson F. 2015. Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites. Biochemistry. 54(27), 4163–4166.","ama":"Veldkamp C, Kiermaier E, Gabel Eissens S, et al. Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites. Biochemistry. 2015;54(27):4163-4166. doi:10.1021/acs.biochem.5b00560"},"date_published":"2015-06-26T00:00:00Z","scopus_import":"1","day":"26","article_processing_charge":"No","status":"public","title":"Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites","intvolume":" 54","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"1618","oa_version":"Submitted Version","type":"journal_article","abstract":[{"text":"CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by CCL19 and CCL21. Here the solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive. Implications for the mechanism of PSGL-1's enhancement of resting T-cell recruitment are discussed.","lang":"eng"}],"issue":"27"},{"file_date_updated":"2020-07-14T12:45:01Z","publist_id":"5634","publication_status":"published","publisher":"Cell Press","department":[{"_id":"CaHe"},{"_id":"MiSi"}],"year":"2015","acknowledgement":"We would like to thank R. Hausschild and E. Papusheva for technical assistance and the service facilities at the IST Austria for continuous support. The caRhoA plasmid was a kind gift of T. Kudoh and A. Takesono. We thank M. Piel and E. Paluch for exchanging unpublished data. ","date_created":"2018-12-11T11:52:35Z","date_updated":"2023-09-07T12:05:08Z","volume":160,"author":[{"id":"4D71A03A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4088-8633","first_name":"Verena","last_name":"Ruprecht","full_name":"Ruprecht, Verena"},{"full_name":"Wieser, Stefan","orcid":"0000-0002-2670-2217","id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","last_name":"Wieser","first_name":"Stefan"},{"first_name":"Andrew","last_name":"Callan Jones","full_name":"Callan Jones, Andrew"},{"full_name":"Smutny, Michael","id":"3FE6E4E8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5920-9090","first_name":"Michael","last_name":"Smutny"},{"full_name":"Morita, Hitoshi","last_name":"Morita","first_name":"Hitoshi","id":"4C6E54C6-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-6453-8075","id":"3BED66BE-F248-11E8-B48F-1D18A9856A87","last_name":"Sako","first_name":"Keisuke","full_name":"Sako, Keisuke"},{"id":"419EECCC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2676-3367","first_name":"Vanessa","last_name":"Barone","full_name":"Barone, Vanessa"},{"full_name":"Ritsch Marte, Monika","last_name":"Ritsch Marte","first_name":"Monika"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","full_name":"Sixt, Michael K"},{"first_name":"Raphaël","last_name":"Voituriez","full_name":"Voituriez, Raphaël"},{"full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"related_material":{"record":[{"id":"961","relation":"dissertation_contains","status":"public"}]},"month":"02","quality_controlled":"1","project":[{"_id":"2529486C-B435-11E9-9278-68D0E5697425","grant_number":"T 560-B17","name":"Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation","call_identifier":"FWF"},{"_id":"2527D5CC-B435-11E9-9278-68D0E5697425","grant_number":"I 812-B12","call_identifier":"FWF","name":"Cell Cortex and Germ Layer Formation in Zebrafish Gastrulation"}],"oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"acknowledged_ssus":[{"_id":"SSU"}],"language":[{"iso":"eng"}],"doi":"10.1016/j.cell.2015.01.008","type":"journal_article","abstract":[{"text":"3D amoeboid cell migration is central to many developmental and disease-related processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid cell migration mode in early zebrafish embryos, termed stable-bleb migration. Stable-bleb cells display an invariant polarized balloon-like shape with exceptional migration speed and persistence. Progenitor cells can be reversibly transformed into stable-bleb cells irrespective of their primary fate and motile characteristics by increasing myosin II activity through biochemical or mechanical stimuli. Using a combination of theory and experiments, we show that, in stable-bleb cells, cortical contractility fluctuations trigger a stochastic switch into amoeboid motility, and a positive feedback between cortical flows and gradients in contractility maintains stable-bleb cell polarization. We further show that rearward cortical flows drive stable-bleb cell migration in various adhesive and non-adhesive environments, unraveling a highly versatile amoeboid migration phenotype.","lang":"eng"}],"issue":"4","status":"public","title":"Cortical contractility triggers a stochastic switch to fast amoeboid cell motility","ddc":["570"],"intvolume":" 160","_id":"1537","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","file":[{"file_name":"IST-2016-484-v1+1_1-s2.0-S0092867415000094-main.pdf","access_level":"open_access","creator":"system","file_size":4362653,"content_type":"application/pdf","file_id":"5003","relation":"main_file","date_updated":"2020-07-14T12:45:01Z","date_created":"2018-12-12T10:13:21Z","checksum":"228d3edf40627d897b3875088a0ac51f"}],"oa_version":"Published Version","pubrep_id":"484","scopus_import":1,"day":"12","has_accepted_license":"1","page":"673 - 685","publication":"Cell","citation":{"apa":"Ruprecht, V., Wieser, S., Callan Jones, A., Smutny, M., Morita, H., Sako, K., … Heisenberg, C.-P. J. (2015). Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. Cell. Cell Press. https://doi.org/10.1016/j.cell.2015.01.008","ieee":"V. Ruprecht et al., “Cortical contractility triggers a stochastic switch to fast amoeboid cell motility,” Cell, vol. 160, no. 4. Cell Press, pp. 673–685, 2015.","ista":"Ruprecht V, Wieser S, Callan Jones A, Smutny M, Morita H, Sako K, Barone V, Ritsch Marte M, Sixt MK, Voituriez R, Heisenberg C-PJ. 2015. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. Cell. 160(4), 673–685.","ama":"Ruprecht V, Wieser S, Callan Jones A, et al. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. Cell. 2015;160(4):673-685. doi:10.1016/j.cell.2015.01.008","chicago":"Ruprecht, Verena, Stefan Wieser, Andrew Callan Jones, Michael Smutny, Hitoshi Morita, Keisuke Sako, Vanessa Barone, et al. “Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility.” Cell. Cell Press, 2015. https://doi.org/10.1016/j.cell.2015.01.008.","short":"V. Ruprecht, S. Wieser, A. Callan Jones, M. Smutny, H. Morita, K. Sako, V. Barone, M. Ritsch Marte, M.K. Sixt, R. Voituriez, C.-P.J. Heisenberg, Cell 160 (2015) 673–685.","mla":"Ruprecht, Verena, et al. “Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility.” Cell, vol. 160, no. 4, Cell Press, 2015, pp. 673–85, doi:10.1016/j.cell.2015.01.008."},"date_published":"2015-02-12T00:00:00Z"},{"type":"journal_article","abstract":[{"lang":"eng","text":"During inflammation, lymph nodes swell with an influx of immune cells. New findings identify a signalling pathway that induces relaxation in the contractile cells that give structure to these organs."}],"publist_id":"5219","issue":"7523","_id":"1877","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2014","publication_status":"published","status":"public","title":"Physiology: Relax and come in","publisher":"Springer Nature","department":[{"_id":"MiSi"}],"intvolume":" 514","author":[{"last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"},{"orcid":"0000-0001-7829-3518","id":"368EE576-F248-11E8-B48F-1D18A9856A87","last_name":"Vaahtomeri","first_name":"Kari","full_name":"Vaahtomeri, Kari"}],"date_created":"2018-12-11T11:54:30Z","date_updated":"2021-01-12T06:53:47Z","oa_version":"None","volume":514,"scopus_import":1,"day":"23","month":"10","publication":"Nature","citation":{"chicago":"Sixt, Michael K, and Kari Vaahtomeri. “Physiology: Relax and Come In.” Nature. Springer Nature, 2014. https://doi.org/10.1038/514441a.","mla":"Sixt, Michael K., and Kari Vaahtomeri. “Physiology: Relax and Come In.” Nature, vol. 514, no. 7523, Springer Nature, 2014, pp. 441–42, doi:10.1038/514441a.","short":"M.K. Sixt, K. Vaahtomeri, Nature 514 (2014) 441–442.","ista":"Sixt MK, Vaahtomeri K. 2014. Physiology: Relax and come in. Nature. 514(7523), 441–442.","ieee":"M. K. Sixt and K. Vaahtomeri, “Physiology: Relax and come in,” Nature, vol. 514, no. 7523. Springer Nature, pp. 441–442, 2014.","apa":"Sixt, M. K., & Vaahtomeri, K. (2014). Physiology: Relax and come in. Nature. Springer Nature. https://doi.org/10.1038/514441a","ama":"Sixt MK, Vaahtomeri K. Physiology: Relax and come in. Nature. 2014;514(7523):441-442. doi:10.1038/514441a"},"article_type":"letter_note","quality_controlled":"1","page":"441 - 442","doi":"10.1038/514441a","date_published":"2014-10-23T00:00:00Z","language":[{"iso":"eng"}]},{"author":[{"first_name":"Sabine","last_name":"Konradi","full_name":"Konradi, Sabine"},{"full_name":"Yasmin, Nighat","first_name":"Nighat","last_name":"Yasmin"},{"full_name":"Haslwanter, Denise","first_name":"Denise","last_name":"Haslwanter"},{"full_name":"Weber, Michele","id":"3A3FC708-F248-11E8-B48F-1D18A9856A87","first_name":"Michele","last_name":"Weber"},{"last_name":"Gesslbauer","first_name":"Bernd","full_name":"Gesslbauer, Bernd"},{"first_name":"Michael K","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K"},{"last_name":"Strobl","first_name":"Herbert","full_name":"Strobl, Herbert"}],"date_updated":"2021-01-12T06:54:01Z","date_created":"2018-12-11T11:54:40Z","oa_version":"None","volume":44,"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","_id":"1910","year":"2014","acknowledgement":"FWF. Grant Number: P22058-B20","title":"Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2","publication_status":"published","status":"public","intvolume":" 44","department":[{"_id":"MiSi"}],"publisher":"Wiley-Blackwell","abstract":[{"lang":"eng","text":"angerhans cells (LCs) are a unique subset of dendritic cells (DCs) that express epithelial adhesion molecules, allowing them to form contacts with epithelial cells and reside in epidermal/epithelial tissues. The dynamic regulation of epithelial adhesion plays a decisive role in the life cycle of LCs. It controls whether LCs remain immature and sessile within the epidermis or mature and egress to initiate immune responses. So far, the molecular machinery regulating epithelial adhesion molecules during LC maturation remains elusive. Here, we generated pure populations of immature human LCs in vitro to systematically probe for gene-expression changes during LC maturation. LCs down-regulate a set of epithelial genes including E-cadherin, while they upregulate the mesenchymal marker N-cadherin known to facilitate cell migration. In addition, N-cadherin is constitutively expressed by monocyte-derived DCs known to exhibit characteristics of both inflammatory-type and interstitial/dermal DCs. Moreover, the transcription factors ZEB1 and ZEB2 (ZEB is zinc-finger E-box-binding homeobox) are upregulated in migratory LCs. ZEB1 and ZEB2 have been shown to induce epithelial-to-mesenchymal transition (EMT) and invasive behavior in cancer cells undergoing metastasis. Our results provide the first hint that the molecular EMT machinery might facilitate LC mobilization. Moreover, our study suggests that N-cadherin plays a role during DC migration."}],"issue":"2","publist_id":"5185","type":"journal_article","date_published":"2014-02-01T00:00:00Z","doi":"10.1002/eji.201343681","language":[{"iso":"eng"}],"publication":"European Journal of Immunology","citation":{"short":"S. Konradi, N. Yasmin, D. Haslwanter, M. Weber, B. Gesslbauer, M.K. Sixt, H. Strobl, European Journal of Immunology 44 (2014) 553–560.","mla":"Konradi, Sabine, et al. “Langerhans Cell Maturation Is Accompanied by Induction of N-Cadherin and the Transcriptional Regulators of Epithelial-Mesenchymal Transition ZEB1/2.” European Journal of Immunology, vol. 44, no. 2, Wiley-Blackwell, 2014, pp. 553–60, doi:10.1002/eji.201343681.","chicago":"Konradi, Sabine, Nighat Yasmin, Denise Haslwanter, Michele Weber, Bernd Gesslbauer, Michael K Sixt, and Herbert Strobl. “Langerhans Cell Maturation Is Accompanied by Induction of N-Cadherin and the Transcriptional Regulators of Epithelial-Mesenchymal Transition ZEB1/2.” European Journal of Immunology. Wiley-Blackwell, 2014. https://doi.org/10.1002/eji.201343681.","ama":"Konradi S, Yasmin N, Haslwanter D, et al. Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2. European Journal of Immunology. 2014;44(2):553-560. doi:10.1002/eji.201343681","ieee":"S. Konradi et al., “Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2,” European Journal of Immunology, vol. 44, no. 2. Wiley-Blackwell, pp. 553–560, 2014.","apa":"Konradi, S., Yasmin, N., Haslwanter, D., Weber, M., Gesslbauer, B., Sixt, M. K., & Strobl, H. (2014). Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2. European Journal of Immunology. Wiley-Blackwell. https://doi.org/10.1002/eji.201343681","ista":"Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt MK, Strobl H. 2014. Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2. European Journal of Immunology. 44(2), 553–560."},"page":"553 - 560","day":"01","month":"02","scopus_import":1},{"scopus_import":1,"day":"28","article_processing_charge":"No","has_accepted_license":"1","article_type":"original","publication":"Nanotechnology","citation":{"apa":"Lamprecht, C., Plochberger, B., Ruprecht, V., Wieser, S., Rankl, C., Heister, E., … Ebner, A. (2014). A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. Nanotechnology. IOP Publishing. https://doi.org/10.1088/0957-4484/25/12/125704","ieee":"C. Lamprecht et al., “A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes,” Nanotechnology, vol. 25, no. 12. IOP Publishing, 2014.","ista":"Lamprecht C, Plochberger B, Ruprecht V, Wieser S, Rankl C, Heister E, Unterauer B, Brameshuber M, Danzberger J, Lukanov P, Flahaut E, Schütz G, Hinterdorfer P, Ebner A. 2014. A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. Nanotechnology. 25(12), 125704.","ama":"Lamprecht C, Plochberger B, Ruprecht V, et al. A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. Nanotechnology. 2014;25(12). doi:10.1088/0957-4484/25/12/125704","chicago":"Lamprecht, Constanze, Birgit Plochberger, Verena Ruprecht, Stefan Wieser, Christian Rankl, Elena Heister, Barbara Unterauer, et al. “A Single-Molecule Approach to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” Nanotechnology. IOP Publishing, 2014. https://doi.org/10.1088/0957-4484/25/12/125704.","short":"C. Lamprecht, B. Plochberger, V. Ruprecht, S. Wieser, C. Rankl, E. Heister, B. Unterauer, M. Brameshuber, J. Danzberger, P. Lukanov, E. Flahaut, G. Schütz, P. Hinterdorfer, A. Ebner, Nanotechnology 25 (2014).","mla":"Lamprecht, Constanze, et al. “A Single-Molecule Approach to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” Nanotechnology, vol. 25, no. 12, 125704, IOP Publishing, 2014, doi:10.1088/0957-4484/25/12/125704."},"date_published":"2014-03-28T00:00:00Z","type":"journal_article","abstract":[{"text":"In the past decade carbon nanotubes (CNTs) have been widely studied as a potential drug-delivery system, especially with functionality for cellular targeting. Yet, little is known about the actual process of docking to cell receptors and transport dynamics after internalization. Here we performed single-particle studies of folic acid (FA) mediated CNT binding to human carcinoma cells and their transport inside the cytosol. In particular, we employed molecular recognition force spectroscopy, an atomic force microscopy based method, to visualize and quantify docking of FA functionalized CNTs to FA binding receptors in terms of binding probability and binding force. We then traced individual fluorescently labeled, FA functionalized CNTs after specific uptake, and created a dynamic 'roadmap' that clearly showed trajectories of directed diffusion and areas of nanotube confinement in the cytosol. Our results demonstrate the potential of a single-molecule approach for investigation of drug-delivery vehicles and their targeting capacity.","lang":"eng"}],"issue":"12","ddc":["570"],"status":"public","title":"A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes","intvolume":" 25","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"1925","oa_version":"Submitted Version","file":[{"checksum":"df4e03d225a19179e7790f6d87a12332","date_created":"2020-05-15T09:21:19Z","date_updated":"2020-07-14T12:45:21Z","file_id":"7856","relation":"main_file","creator":"dernst","file_size":3804152,"content_type":"application/pdf","access_level":"open_access","file_name":"2014_Nanotechnology_Lamprecht.pdf"}],"month":"03","oa":1,"language":[{"iso":"eng"}],"doi":"10.1088/0957-4484/25/12/125704","article_number":"125704","file_date_updated":"2020-07-14T12:45:21Z","publist_id":"5169","publication_status":"published","department":[{"_id":"CaHe"},{"_id":"MiSi"}],"publisher":"IOP Publishing","acknowledgement":"This work was supported by EC grant Marie Curie RTN-CT-2006-035616, CARBIO 'Carbon nanotubes for biomedical applications' and Austrian FFG grant mnt-era.net 823980, 'IntelliTip'.\r\n","year":"2014","date_created":"2018-12-11T11:54:45Z","date_updated":"2021-01-12T06:54:07Z","volume":25,"author":[{"first_name":"Constanze","last_name":"Lamprecht","full_name":"Lamprecht, Constanze"},{"full_name":"Plochberger, Birgit","last_name":"Plochberger","first_name":"Birgit"},{"full_name":"Ruprecht, Verena","orcid":"0000-0003-4088-8633","id":"4D71A03A-F248-11E8-B48F-1D18A9856A87","last_name":"Ruprecht","first_name":"Verena"},{"orcid":"0000-0002-2670-2217","id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","last_name":"Wieser","first_name":"Stefan","full_name":"Wieser, Stefan"},{"full_name":"Rankl, Christian","first_name":"Christian","last_name":"Rankl"},{"full_name":"Heister, Elena","first_name":"Elena","last_name":"Heister"},{"full_name":"Unterauer, Barbara","first_name":"Barbara","last_name":"Unterauer"},{"last_name":"Brameshuber","first_name":"Mario","full_name":"Brameshuber, Mario"},{"last_name":"Danzberger","first_name":"Jürgen","full_name":"Danzberger, Jürgen"},{"last_name":"Lukanov","first_name":"Petar","full_name":"Lukanov, Petar"},{"last_name":"Flahaut","first_name":"Emmanuel","full_name":"Flahaut, Emmanuel"},{"last_name":"Schütz","first_name":"Gerhard","full_name":"Schütz, Gerhard"},{"full_name":"Hinterdorfer, Peter","first_name":"Peter","last_name":"Hinterdorfer"},{"first_name":"Andreas","last_name":"Ebner","full_name":"Ebner, Andreas"}]}]