---
_id: '5408'
abstract:
- lang: eng
text: "We consider two-player partial-observation stochastic games where player
1 has partial observation and player 2 has perfect observation. The winning condition
we study are omega-regular conditions specified as parity objectives. The qualitative
analysis problem given a partial-observation stochastic game and a parity objective
asks whether there is a strategy to ensure that the objective is satisfied with
probability 1 (resp. positive probability). While the qualitative analysis problems
are known to be undecidable even for very special cases of parity objectives,
they were shown to be decidable in 2EXPTIME under finite-memory strategies. We
improve the complexity and show that the qualitative analysis problems for partial-observation
stochastic parity games under finite-memory strategies are \r\nEXPTIME-complete;
and also establish optimal (exponential) memory bounds for finite-memory strategies
required for qualitative analysis. "
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Laurent
full_name: Doyen, Laurent
last_name: Doyen
- first_name: Sumit
full_name: Nain, Sumit
last_name: Nain
- first_name: Moshe
full_name: Vardi, Moshe
last_name: Vardi
citation:
ama: Chatterjee K, Doyen L, Nain S, Vardi M. The Complexity of Partial-Observation
Stochastic Parity Games with Finite-Memory Strategies. IST Austria; 2013.
doi:10.15479/AT:IST-2013-141-v1-1
apa: Chatterjee, K., Doyen, L., Nain, S., & Vardi, M. (2013). The complexity
of partial-observation stochastic parity games with finite-memory strategies.
IST Austria. https://doi.org/10.15479/AT:IST-2013-141-v1-1
chicago: Chatterjee, Krishnendu, Laurent Doyen, Sumit Nain, and Moshe Vardi. The
Complexity of Partial-Observation Stochastic Parity Games with Finite-Memory Strategies.
IST Austria, 2013. https://doi.org/10.15479/AT:IST-2013-141-v1-1.
ieee: K. Chatterjee, L. Doyen, S. Nain, and M. Vardi, The complexity of partial-observation
stochastic parity games with finite-memory strategies. IST Austria, 2013.
ista: Chatterjee K, Doyen L, Nain S, Vardi M. 2013. The complexity of partial-observation
stochastic parity games with finite-memory strategies, IST Austria, 17p.
mla: Chatterjee, Krishnendu, et al. The Complexity of Partial-Observation Stochastic
Parity Games with Finite-Memory Strategies. IST Austria, 2013, doi:10.15479/AT:IST-2013-141-v1-1.
short: K. Chatterjee, L. Doyen, S. Nain, M. Vardi, The Complexity of Partial-Observation
Stochastic Parity Games with Finite-Memory Strategies, IST Austria, 2013.
date_created: 2018-12-12T11:39:10Z
date_published: 2013-09-12T00:00:00Z
date_updated: 2023-02-23T10:33:11Z
day: '12'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2013-141-v1-1
file:
- access_level: open_access
checksum: 226bc791124f8d3138379778ce834e86
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:16Z
date_updated: 2020-07-14T12:46:46Z
file_id: '5477'
file_name: IST-2013-141-v1+1_main-tech-rpt.pdf
file_size: 300481
relation: main_file
file_date_updated: 2020-07-14T12:46:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '17'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '141'
related_material:
record:
- id: '2213'
relation: later_version
status: public
status: public
title: The complexity of partial-observation stochastic parity games with finite-memory
strategies
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...
---
_id: '5410'
abstract:
- lang: eng
text: "Board games, like Tic-Tac-Toe and CONNECT-4, play an important role not only
in development of mathematical and logical skills, but also in emotional and social
development. In this paper, we address the problem of generating targeted starting
positions for such games. This can facilitate new approaches for bringing novice
players to mastery, and also leads to discovery of interesting game variants.
\r\nOur approach generates starting states of varying hardness levels for player
1 in a two-player board game, given rules of the board game, the desired number
of steps required for player 1 to win, and the expertise levels of the two players.
Our approach leverages symbolic methods and iterative simulation to efficiently
search the extremely large state space. We present experimental results that include
discovery of states of varying hardness levels for several simple grid-based board
games. Also, the presence of such states for standard game variants like Tic-Tac-Toe
on board size 4x4 opens up new games to be played that have not been played for
ages since the default start state is heavily biased. "
alternative_title:
- IST Austria Technical Report
author:
- first_name: Umair
full_name: Ahmed, Umair
last_name: Ahmed
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Sumit
full_name: Gulwani, Sumit
last_name: Gulwani
citation:
ama: Ahmed U, Chatterjee K, Gulwani S. Automatic Generation of Alternative Starting
Positions for Traditional Board Games. IST Austria; 2013. doi:10.15479/AT:IST-2013-146-v1-1
apa: Ahmed, U., Chatterjee, K., & Gulwani, S. (2013). Automatic generation
of alternative starting positions for traditional board games. IST Austria.
https://doi.org/10.15479/AT:IST-2013-146-v1-1
chicago: Ahmed, Umair, Krishnendu Chatterjee, and Sumit Gulwani. Automatic Generation
of Alternative Starting Positions for Traditional Board Games. IST Austria,
2013. https://doi.org/10.15479/AT:IST-2013-146-v1-1.
ieee: U. Ahmed, K. Chatterjee, and S. Gulwani, Automatic generation of alternative
starting positions for traditional board games. IST Austria, 2013.
ista: Ahmed U, Chatterjee K, Gulwani S. 2013. Automatic generation of alternative
starting positions for traditional board games, IST Austria, 13p.
mla: Ahmed, Umair, et al. Automatic Generation of Alternative Starting Positions
for Traditional Board Games. IST Austria, 2013, doi:10.15479/AT:IST-2013-146-v1-1.
short: U. Ahmed, K. Chatterjee, S. Gulwani, Automatic Generation of Alternative
Starting Positions for Traditional Board Games, IST Austria, 2013.
date_created: 2018-12-12T11:39:10Z
date_published: 2013-12-03T00:00:00Z
date_updated: 2023-02-23T10:00:50Z
day: '03'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2013-146-v1-1
file:
- access_level: open_access
checksum: 409f3aaaf1184e4057b89cbb449dac80
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:54:06Z
date_updated: 2020-07-14T12:46:46Z
file_id: '5528'
file_name: IST-2013-146-v1+1_main.pdf
file_size: 818189
relation: main_file
file_date_updated: 2020-07-14T12:46:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '13'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '146'
related_material:
record:
- id: '1481'
relation: later_version
status: public
status: public
title: Automatic generation of alternative starting positions for traditional board
games
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...
---
_id: '2329'
abstract:
- lang: eng
text: 'Two-player games on graphs are central in many problems in formal verification
and program analysis such as synthesis and verification of open systems. In this
work, we consider both finite-state game graphs, and recursive game graphs (or
pushdown game graphs) that model the control flow of sequential programs with
recursion. The objectives we study are multidimensional mean-payoff objectives,
where the goal of player 1 is to ensure that the mean-payoff is non-negative in
all dimensions. In pushdown games two types of strategies are relevant: (1) global
strategies, that depend on the entire global history; and (2) modular strategies,
that have only local memory and thus do not depend on the context of invocation.
Our main contributions are as follows: (1) We show that finite-state multidimensional
mean-payoff games can be solved in polynomial time if the number of dimensions
and the maximal absolute value of the weights are fixed; whereas if the number
of dimensions is arbitrary, then the problem is known to be coNP-complete. (2)
We show that pushdown graphs with multidimensional mean-payoff objectives can
be solved in polynomial time. For both (1) and (2) our algorithms are based on
hyperplane separation technique. (3) For pushdown games under global strategies
both one and multidimensional mean-payoff objectives problems are known to be
undecidable, and we show that under modular strategies the multidimensional problem
is also undecidable; under modular strategies the one-dimensional problem is NP-complete.
We show that if the number of modules, the number of exits, and the maximal absolute
value of the weights are fixed, then pushdown games under modular strategies with
one-dimensional mean-payoff objectives can be solved in polynomial time, and if
either the number of exits or the number of modules is unbounded, then the problem
is NP-hard. (4) Finally we show that a fixed parameter tractable algorithm for
finite-state multidimensional mean-payoff games or pushdown games under modular
strategies with one-dimensional mean-payoff objectives would imply the fixed parameter
tractability of parity games.'
alternative_title:
- LNCS
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Yaron
full_name: Velner, Yaron
last_name: Velner
citation:
ama: Chatterjee K, Velner Y. Hyperplane separation technique for multidimensional
mean-payoff games. 2013;8052:500-515. doi:10.1007/978-3-642-40184-8_35
apa: 'Chatterjee, K., & Velner, Y. (2013). Hyperplane separation technique for
multidimensional mean-payoff games. Presented at the CONCUR: Concurrency Theory,
Buenos Aires, Argentinia: Springer. https://doi.org/10.1007/978-3-642-40184-8_35'
chicago: Chatterjee, Krishnendu, and Yaron Velner. “Hyperplane Separation Technique
for Multidimensional Mean-Payoff Games.” Lecture Notes in Computer Science. Springer,
2013. https://doi.org/10.1007/978-3-642-40184-8_35.
ieee: K. Chatterjee and Y. Velner, “Hyperplane separation technique for multidimensional
mean-payoff games,” vol. 8052. Springer, pp. 500–515, 2013.
ista: Chatterjee K, Velner Y. 2013. Hyperplane separation technique for multidimensional
mean-payoff games. 8052, 500–515.
mla: Chatterjee, Krishnendu, and Yaron Velner. Hyperplane Separation Technique
for Multidimensional Mean-Payoff Games. Vol. 8052, Springer, 2013, pp. 500–15,
doi:10.1007/978-3-642-40184-8_35.
short: K. Chatterjee, Y. Velner, 8052 (2013) 500–515.
conference:
end_date: 2013-08-30
location: Buenos Aires, Argentinia
name: 'CONCUR: Concurrency Theory'
start_date: 2013-08-27
date_created: 2018-12-11T11:57:01Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2023-02-23T13:00:42Z
day: '01'
department:
- _id: KrCh
doi: 10.1007/978-3-642-40184-8_35
ec_funded: 1
external_id:
arxiv:
- '1210.3141'
intvolume: ' 8052'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1210.3141
month: '08'
oa: 1
oa_version: Preprint
page: 500 - 515
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication_status: published
publisher: Springer
publist_id: '4597'
quality_controlled: '1'
related_material:
record:
- id: '717'
relation: later_version
status: public
scopus_import: 1
series_title: Lecture Notes in Computer Science
status: public
title: Hyperplane separation technique for multidimensional mean-payoff games
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8052
year: '2013'
...
---
_id: '9749'
abstract:
- lang: eng
text: Cooperative behavior, where one individual incurs a cost to help another,
is a wide spread phenomenon. Here we study direct reciprocity in the context of
the alternating Prisoner's Dilemma. We consider all strategies that can be implemented
by one and two-state automata. We calculate the payoff matrix of all pairwise
encounters in the presence of noise. We explore deterministic selection dynamics
with and without mutation. Using different error rates and payoff values, we observe
convergence to a small number of distinct equilibria. Two of them are uncooperative
strict Nash equilibria representing always-defect (ALLD) and Grim. The third equilibrium
is mixed and represents a cooperative alliance of several strategies, dominated
by a strategy which we call Forgiver. Forgiver cooperates whenever the opponent
has cooperated; it defects once when the opponent has defected, but subsequently
Forgiver attempts to re-establish cooperation even if the opponent has defected
again. Forgiver is not an evolutionarily stable strategy, but the alliance, which
it rules, is asymptotically stable. For a wide range of parameter values the most
commonly observed outcome is convergence to the mixed equilibrium, dominated by
Forgiver. Our results show that although forgiving might incur a short-term loss
it can lead to a long-term gain. Forgiveness facilitates stable cooperation in
the presence of exploitation and noise.
article_processing_charge: No
author:
- first_name: Benjamin
full_name: Zagorsky, Benjamin
last_name: Zagorsky
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Zagorsky B, Reiter J, Chatterjee K, Nowak M. Forgiver triumphs in alternating
prisoner’s dilemma . 2013. doi:10.1371/journal.pone.0080814.s001
apa: Zagorsky, B., Reiter, J., Chatterjee, K., & Nowak, M. (2013). Forgiver
triumphs in alternating prisoner’s dilemma . Public Library of Science. https://doi.org/10.1371/journal.pone.0080814.s001
chicago: Zagorsky, Benjamin, Johannes Reiter, Krishnendu Chatterjee, and Martin
Nowak. “Forgiver Triumphs in Alternating Prisoner’s Dilemma .” Public Library
of Science, 2013. https://doi.org/10.1371/journal.pone.0080814.s001.
ieee: B. Zagorsky, J. Reiter, K. Chatterjee, and M. Nowak, “Forgiver triumphs in
alternating prisoner’s dilemma .” Public Library of Science, 2013.
ista: Zagorsky B, Reiter J, Chatterjee K, Nowak M. 2013. Forgiver triumphs in alternating
prisoner’s dilemma , Public Library of Science, 10.1371/journal.pone.0080814.s001.
mla: Zagorsky, Benjamin, et al. Forgiver Triumphs in Alternating Prisoner’s Dilemma
. Public Library of Science, 2013, doi:10.1371/journal.pone.0080814.s001.
short: B. Zagorsky, J. Reiter, K. Chatterjee, M. Nowak, (2013).
date_created: 2021-07-28T15:45:07Z
date_published: 2013-12-12T00:00:00Z
date_updated: 2023-02-23T10:34:39Z
day: '12'
department:
- _id: KrCh
doi: 10.1371/journal.pone.0080814.s001
month: '12'
oa_version: Published Version
publisher: Public Library of Science
related_material:
record:
- id: '2247'
relation: used_in_publication
status: public
status: public
title: 'Forgiver triumphs in alternating prisoner''s dilemma '
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2013'
...
---
_id: '10902'
abstract:
- lang: eng
text: We consider how to edit strings from a source language so that the edited
strings belong to a target language, where the languages are given as deterministic
finite automata. Non-streaming (or offline) transducers perform edits given the
whole source string. We show that the class of deterministic one-pass transducers
with registers along with increment and min operation suffices for computing optimal
edit distance, whereas the same class of transducers without the min operation
is not sufficient. Streaming (or online) transducers perform edits as the letters
of the source string are received. We present a polynomial time algorithm for
the partial-repair problem that given a bound α asks for the construction of a
deterministic streaming transducer (if one exists) that ensures that the ‘maximum
fraction’ η of the strings of the source language are edited, within cost α, to
the target language.
acknowledgement: 'The research was supported by Austrian Science Fund (FWF) Grant
No P 23499-N23, FWF NFN Grant No S11407-N23 (RiSE), ERC Start grant (279307: Graph
Games), and Microsoft faculty fellows award. Thanks to Gabriele Puppis for suggesting
the problem of identifying a deterministic transducer to compute the optimal cost,
and to Martin Chmelik for his comments on the introduction.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Siddhesh
full_name: Chaubal, Siddhesh
last_name: Chaubal
- first_name: Sasha
full_name: Rubin, Sasha
id: 2EC51194-F248-11E8-B48F-1D18A9856A87
last_name: Rubin
citation:
ama: 'Chatterjee K, Chaubal S, Rubin S. How to travel between languages. In: 7th
International Conference on Language and Automata Theory and Applications.
Vol 7810. LNCS. Berlin, Heidelberg: Springer Nature; 2013:214-225. doi:10.1007/978-3-642-37064-9_20'
apa: 'Chatterjee, K., Chaubal, S., & Rubin, S. (2013). How to travel between
languages. In 7th International Conference on Language and Automata Theory
and Applications (Vol. 7810, pp. 214–225). Berlin, Heidelberg: Springer Nature.
https://doi.org/10.1007/978-3-642-37064-9_20'
chicago: 'Chatterjee, Krishnendu, Siddhesh Chaubal, and Sasha Rubin. “How to Travel
between Languages.” In 7th International Conference on Language and Automata
Theory and Applications, 7810:214–25. LNCS. Berlin, Heidelberg: Springer Nature,
2013. https://doi.org/10.1007/978-3-642-37064-9_20.'
ieee: K. Chatterjee, S. Chaubal, and S. Rubin, “How to travel between languages,”
in 7th International Conference on Language and Automata Theory and Applications,
Bilbao, Spain, 2013, vol. 7810, pp. 214–225.
ista: 'Chatterjee K, Chaubal S, Rubin S. 2013. How to travel between languages.
7th International Conference on Language and Automata Theory and Applications.
LATA: Conference on Language and Automata Theory and ApplicationsLNCS, LNCS, vol.
7810, 214–225.'
mla: Chatterjee, Krishnendu, et al. “How to Travel between Languages.” 7th International
Conference on Language and Automata Theory and Applications, vol. 7810, Springer
Nature, 2013, pp. 214–25, doi:10.1007/978-3-642-37064-9_20.
short: K. Chatterjee, S. Chaubal, S. Rubin, in:, 7th International Conference on
Language and Automata Theory and Applications, Springer Nature, Berlin, Heidelberg,
2013, pp. 214–225.
conference:
end_date: 2013-04-05
location: Bilbao, Spain
name: 'LATA: Conference on Language and Automata Theory and Applications'
start_date: 2013-04-02
date_created: 2022-03-21T07:56:21Z
date_published: 2013-04-15T00:00:00Z
date_updated: 2023-09-05T15:10:38Z
day: '15'
department:
- _id: KrCh
doi: 10.1007/978-3-642-37064-9_20
ec_funded: 1
intvolume: ' 7810'
language:
- iso: eng
month: '04'
oa_version: None
page: 214-225
place: Berlin, Heidelberg
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: 7th International Conference on Language and Automata Theory and Applications
publication_identifier:
eisbn:
- '9783642370649'
eissn:
- 1611-3349
isbn:
- '9783642370632'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: LNCS
status: public
title: How to travel between languages
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7810
year: '2013'
...
---
_id: '2247'
abstract:
- lang: eng
text: Cooperative behavior, where one individual incurs a cost to help another,
is a wide spread phenomenon. Here we study direct reciprocity in the context of
the alternating Prisoner's Dilemma. We consider all strategies that can be implemented
by one and two-state automata. We calculate the payoff matrix of all pairwise
encounters in the presence of noise. We explore deterministic selection dynamics
with and without mutation. Using different error rates and payoff values, we observe
convergence to a small number of distinct equilibria. Two of them are uncooperative
strict Nash equilibria representing always-defect (ALLD) and Grim. The third equilibrium
is mixed and represents a cooperative alliance of several strategies, dominated
by a strategy which we call Forgiver. Forgiver cooperates whenever the opponent
has cooperated; it defects once when the opponent has defected, but subsequently
Forgiver attempts to re-establish cooperation even if the opponent has defected
again. Forgiver is not an evolutionarily stable strategy, but the alliance, which
it rules, is asymptotically stable. For a wide range of parameter values the most
commonly observed outcome is convergence to the mixed equilibrium, dominated by
Forgiver. Our results show that although forgiving might incur a short-term loss
it can lead to a long-term gain. Forgiveness facilitates stable cooperation in
the presence of exploitation and noise.
article_number: e80814
author:
- first_name: Benjamin
full_name: Zagorsky, Benjamin
last_name: Zagorsky
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Zagorsky B, Reiter J, Chatterjee K, Nowak M. Forgiver triumphs in alternating
prisoner’s dilemma . PLoS One. 2013;8(12). doi:10.1371/journal.pone.0080814
apa: Zagorsky, B., Reiter, J., Chatterjee, K., & Nowak, M. (2013). Forgiver
triumphs in alternating prisoner’s dilemma . PLoS One. Public Library of
Science. https://doi.org/10.1371/journal.pone.0080814
chicago: Zagorsky, Benjamin, Johannes Reiter, Krishnendu Chatterjee, and Martin
Nowak. “Forgiver Triumphs in Alternating Prisoner’s Dilemma .” PLoS One.
Public Library of Science, 2013. https://doi.org/10.1371/journal.pone.0080814.
ieee: B. Zagorsky, J. Reiter, K. Chatterjee, and M. Nowak, “Forgiver triumphs in
alternating prisoner’s dilemma ,” PLoS One, vol. 8, no. 12. Public Library
of Science, 2013.
ista: Zagorsky B, Reiter J, Chatterjee K, Nowak M. 2013. Forgiver triumphs in alternating
prisoner’s dilemma . PLoS One. 8(12), e80814.
mla: Zagorsky, Benjamin, et al. “Forgiver Triumphs in Alternating Prisoner’s Dilemma
.” PLoS One, vol. 8, no. 12, e80814, Public Library of Science, 2013, doi:10.1371/journal.pone.0080814.
short: B. Zagorsky, J. Reiter, K. Chatterjee, M. Nowak, PLoS One 8 (2013).
date_created: 2018-12-11T11:56:33Z
date_published: 2013-12-12T00:00:00Z
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name: 'Quantitative Graph Games: Theory and Applications'
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call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
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title: 'Forgiver triumphs in alternating prisoner''s dilemma '
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name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
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type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2013'
...
---
_id: '2858'
abstract:
- lang: eng
text: Tumor growth is caused by the acquisition of driver mutations, which enhance
the net reproductive rate of cells. Driver mutations may increase cell division,
reduce cell death, or allow cells to overcome density-limiting effects. We study
the dynamics of tumor growth as one additional driver mutation is acquired. Our
models are based on two-type branching processes that terminate in either tumor
disappearance or tumor detection. In our first model, both cell types grow exponentially,
with a faster rate for cells carrying the additional driver. We find that the
additional driver mutation does not affect the survival probability of the lesion,
but can substantially reduce the time to reach the detectable size if the lesion
is slow growing. In our second model, cells lacking the additional driver cannot
exceed a fixed carrying capacity, due to density limitations. In this case, the
time to detection depends strongly on this carrying capacity. Our model provides
a quantitative framework for studying tumor dynamics during different stages of
progression. We observe that early, small lesions need additional drivers, while
late stage metastases are only marginally affected by them. These results help
to explain why additional driver mutations are typically not detected in fast-growing
metastases.
author:
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Ivana
full_name: Božić, Ivana
last_name: Božić
- first_name: Benjamin
full_name: Allen, Benjamin
id: 135B5B70-E9D2-11E9-BD74-BB415DA2B523
last_name: Allen
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Reiter J, Božić I, Allen B, Chatterjee K, Nowak M. The effect of one additional
driver mutation on tumor progression. Evolutionary Applications. 2013;6(1):34-45.
doi:10.1111/eva.12020
apa: Reiter, J., Božić, I., Allen, B., Chatterjee, K., & Nowak, M. (2013). The
effect of one additional driver mutation on tumor progression. Evolutionary
Applications. Wiley-Blackwell. https://doi.org/10.1111/eva.12020
chicago: Reiter, Johannes, Ivana Božić, Benjamin Allen, Krishnendu Chatterjee, and
Martin Nowak. “The Effect of One Additional Driver Mutation on Tumor Progression.”
Evolutionary Applications. Wiley-Blackwell, 2013. https://doi.org/10.1111/eva.12020.
ieee: J. Reiter, I. Božić, B. Allen, K. Chatterjee, and M. Nowak, “The effect of
one additional driver mutation on tumor progression,” Evolutionary Applications,
vol. 6, no. 1. Wiley-Blackwell, pp. 34–45, 2013.
ista: Reiter J, Božić I, Allen B, Chatterjee K, Nowak M. 2013. The effect of one
additional driver mutation on tumor progression. Evolutionary Applications. 6(1),
34–45.
mla: Reiter, Johannes, et al. “The Effect of One Additional Driver Mutation on Tumor
Progression.” Evolutionary Applications, vol. 6, no. 1, Wiley-Blackwell,
2013, pp. 34–45, doi:10.1111/eva.12020.
short: J. Reiter, I. Božić, B. Allen, K. Chatterjee, M. Nowak, Evolutionary Applications
6 (2013) 34–45.
date_created: 2018-12-11T11:59:58Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2023-09-07T11:40:43Z
day: '01'
ddc:
- '570'
department:
- _id: KrCh
doi: 10.1111/eva.12020
ec_funded: 1
file:
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checksum: e2955b3889f8a823c3d5a72cb16f8957
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creator: system
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file_name: IST-2016-415-v1+1_Reiter_et_al-2013-Evolutionary_Applications.pdf
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month: '01'
oa: 1
oa_version: Published Version
page: 34 - 45
project:
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call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
publication: Evolutionary Applications
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3931'
pubrep_id: '415'
quality_controlled: '1'
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title: The effect of one additional driver mutation on tumor progression
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2013'
...
---
_id: '2816'
abstract:
- lang: eng
text: In solid tumors, targeted treatments can lead to dramatic regressions, but
responses are often short-lived because resistant cancer cells arise. The major
strategy proposed for overcoming resistance is combination therapy. We present
a mathematical model describing the evolutionary dynamics of lesions in response
to treatment. We first studied 20 melanoma patients receiving vemurafenib. We
then applied our model to an independent set of pancreatic, colorectal, and melanoma
cancer patients with metastatic disease. We find that dual therapy results in
long-term disease control for most patients, if there are no single mutations
that cause cross-resistance to both drugs; in patients with large disease burden,
triple therapy is needed. We also find that simultaneous therapy with two drugs
is much more effective than sequential therapy. Our results provide realistic
expectations for the efficacy of new drug combinations and inform the design of
trials for new cancer therapeutics.
article_number: e00747
author:
- first_name: Ivana
full_name: Božić, Ivana
last_name: Božić
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Benjamin
full_name: Allen, Benjamin
last_name: Allen
- first_name: Tibor
full_name: Antal, Tibor
last_name: Antal
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Preya
full_name: Shah, Preya
last_name: Shah
- first_name: Yo
full_name: Moon, Yo
last_name: Moon
- first_name: Amin
full_name: Yaqubie, Amin
last_name: Yaqubie
- first_name: Nicole
full_name: Kelly, Nicole
last_name: Kelly
- first_name: Dung
full_name: Le, Dung
last_name: Le
- first_name: Evan
full_name: Lipson, Evan
last_name: Lipson
- first_name: Paul
full_name: Chapman, Paul
last_name: Chapman
- first_name: Luis
full_name: Diaz, Luis
last_name: Diaz
- first_name: Bert
full_name: Vogelstein, Bert
last_name: Vogelstein
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Božić I, Reiter J, Allen B, et al. Evolutionary dynamics of cancer in response
to targeted combination therapy. eLife. 2013;2. doi:10.7554/eLife.00747
apa: Božić, I., Reiter, J., Allen, B., Antal, T., Chatterjee, K., Shah, P., … Nowak,
M. (2013). Evolutionary dynamics of cancer in response to targeted combination
therapy. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.00747
chicago: Božić, Ivana, Johannes Reiter, Benjamin Allen, Tibor Antal, Krishnendu
Chatterjee, Preya Shah, Yo Moon, et al. “Evolutionary Dynamics of Cancer in Response
to Targeted Combination Therapy.” ELife. eLife Sciences Publications, 2013.
https://doi.org/10.7554/eLife.00747.
ieee: I. Božić et al., “Evolutionary dynamics of cancer in response to targeted
combination therapy,” eLife, vol. 2. eLife Sciences Publications, 2013.
ista: Božić I, Reiter J, Allen B, Antal T, Chatterjee K, Shah P, Moon Y, Yaqubie
A, Kelly N, Le D, Lipson E, Chapman P, Diaz L, Vogelstein B, Nowak M. 2013. Evolutionary
dynamics of cancer in response to targeted combination therapy. eLife. 2, e00747.
mla: Božić, Ivana, et al. “Evolutionary Dynamics of Cancer in Response to Targeted
Combination Therapy.” ELife, vol. 2, e00747, eLife Sciences Publications,
2013, doi:10.7554/eLife.00747.
short: I. Božić, J. Reiter, B. Allen, T. Antal, K. Chatterjee, P. Shah, Y. Moon,
A. Yaqubie, N. Kelly, D. Le, E. Lipson, P. Chapman, L. Diaz, B. Vogelstein, M.
Nowak, ELife 2 (2013).
date_created: 2018-12-11T11:59:45Z
date_published: 2013-06-25T00:00:00Z
date_updated: 2023-09-07T11:40:43Z
day: '25'
ddc:
- '570'
- '610'
department:
- _id: KrCh
doi: 10.7554/eLife.00747
file:
- access_level: open_access
checksum: 2c38c47815eacd8fa66cb8b404cf7c61
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:48Z
date_updated: 2020-07-14T12:45:49Z
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language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '3985'
pubrep_id: '134'
quality_controlled: '1'
related_material:
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status: public
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status: public
title: Evolutionary dynamics of cancer in response to targeted combination therapy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2013'
...
---
_id: '2000'
abstract:
- lang: eng
text: In this work we present a flexible tool for tumor progression, which simulates
the evolutionary dynamics of cancer. Tumor progression implements a multi-type
branching process where the key parameters are the fitness landscape, the mutation
rate, and the average time of cell division. The fitness of a cancer cell depends
on the mutations it has accumulated. The input to our tool could be any fitness
landscape, mutation rate, and cell division time, and the tool produces the growth
dynamics and all relevant statistics.
alternative_title:
- LNCS
author:
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Ivana
full_name: Božić, Ivana
last_name: Božić
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: 'Reiter J, Božić I, Chatterjee K, Nowak M. TTP: Tool for tumor progression.
In: Proceedings of 25th Int. Conf. on Computer Aided Verification. Vol
8044. Lecture Notes in Computer Science. Springer; 2013:101-106. doi:10.1007/978-3-642-39799-8_6'
apa: 'Reiter, J., Božić, I., Chatterjee, K., & Nowak, M. (2013). TTP: Tool for
tumor progression. In Proceedings of 25th Int. Conf. on Computer Aided Verification
(Vol. 8044, pp. 101–106). St. Petersburg, Russia: Springer. https://doi.org/10.1007/978-3-642-39799-8_6'
chicago: 'Reiter, Johannes, Ivana Božić, Krishnendu Chatterjee, and Martin Nowak.
“TTP: Tool for Tumor Progression.” In Proceedings of 25th Int. Conf. on Computer
Aided Verification, 8044:101–6. Lecture Notes in Computer Science. Springer,
2013. https://doi.org/10.1007/978-3-642-39799-8_6.'
ieee: 'J. Reiter, I. Božić, K. Chatterjee, and M. Nowak, “TTP: Tool for tumor progression,”
in Proceedings of 25th Int. Conf. on Computer Aided Verification, St. Petersburg,
Russia, 2013, vol. 8044, pp. 101–106.'
ista: 'Reiter J, Božić I, Chatterjee K, Nowak M. 2013. TTP: Tool for tumor progression.
Proceedings of 25th Int. Conf. on Computer Aided Verification. CAV: Computer Aided
VerificationLecture Notes in Computer Science, LNCS, vol. 8044, 101–106.'
mla: 'Reiter, Johannes, et al. “TTP: Tool for Tumor Progression.” Proceedings
of 25th Int. Conf. on Computer Aided Verification, vol. 8044, Springer, 2013,
pp. 101–06, doi:10.1007/978-3-642-39799-8_6.'
short: J. Reiter, I. Božić, K. Chatterjee, M. Nowak, in:, Proceedings of 25th Int.
Conf. on Computer Aided Verification, Springer, 2013, pp. 101–106.
conference:
end_date: 2013-07-19
location: St. Petersburg, Russia
name: 'CAV: Computer Aided Verification'
start_date: 2013-07-13
date_created: 2018-12-11T11:55:08Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2023-09-07T11:40:43Z
day: '01'
department:
- _id: KrCh
doi: 10.1007/978-3-642-39799-8_6
ec_funded: 1
external_id:
arxiv:
- '1303.5251'
intvolume: ' 8044'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1303.5251
month: '01'
oa: 1
oa_version: Preprint
page: 101 - 106
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: Proceedings of 25th Int. Conf. on Computer Aided Verification
publication_status: published
publisher: Springer
publist_id: '5077'
quality_controlled: '1'
related_material:
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series_title: Lecture Notes in Computer Science
status: public
title: 'TTP: Tool for tumor progression'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8044
year: '2013'
...
---
_id: '2305'
abstract:
- lang: eng
text: We study the complexity of central controller synthesis problems for finite-state
Markov decision processes, where the objective is to optimize both the expected
mean-payoff performance of the system and its stability. e argue that the basic
theoretical notion of expressing the stability in terms of the variance of the
mean-payoff (called global variance in our paper) is not always sufficient, since
it ignores possible instabilities on respective runs. For this reason we propose
alernative definitions of stability, which we call local and hybrid variance,
and which express how rewards on each run deviate from the run's own mean-payoff
and from the expected mean-payoff, respectively. We show that a strategy ensuring
both the expected mean-payoff and the variance below given bounds requires randomization
and memory, under all the above semantics of variance. We then look at the problem
of determining whether there is a such a strategy. For the global variance, we
show that the problem is in PSPACE, and that the answer can be approximated in
pseudo-polynomial time. For the hybrid variance, the analogous decision problem
is in NP, and a polynomial-time approximating algorithm also exists. For local
variance, we show that the decision problem is in NP. Since the overall performance
can be traded for stability (and vice versa), we also present algorithms for approximating
the associated Pareto curve in all the three cases. Finally, we study a special
case of the decision problems, where we require a given expected mean-payoff together
with zero variance. Here we show that the problems can be all solved in polynomial
time.
author:
- first_name: Tomáš
full_name: Brázdil, Tomáš
last_name: Brázdil
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Vojtěch
full_name: Forejt, Vojtěch
last_name: Forejt
- first_name: Antonín
full_name: Kučera, Antonín
last_name: Kučera
citation:
ama: 'Brázdil T, Chatterjee K, Forejt V, Kučera A. Trading performance for stability
in Markov decision processes. In: 28th Annual ACM/IEEE Symposium. IEEE;
2013:331-340. doi:10.1109/LICS.2013.39'
apa: 'Brázdil, T., Chatterjee, K., Forejt, V., & Kučera, A. (2013). Trading
performance for stability in Markov decision processes. In 28th Annual ACM/IEEE
Symposium (pp. 331–340). New Orleans, LA, United States: IEEE. https://doi.org/10.1109/LICS.2013.39'
chicago: Brázdil, Tomáš, Krishnendu Chatterjee, Vojtěch Forejt, and Antonín Kučera.
“Trading Performance for Stability in Markov Decision Processes.” In 28th Annual
ACM/IEEE Symposium, 331–40. IEEE, 2013. https://doi.org/10.1109/LICS.2013.39.
ieee: T. Brázdil, K. Chatterjee, V. Forejt, and A. Kučera, “Trading performance
for stability in Markov decision processes,” in 28th Annual ACM/IEEE Symposium,
New Orleans, LA, United States, 2013, pp. 331–340.
ista: 'Brázdil T, Chatterjee K, Forejt V, Kučera A. 2013. Trading performance for
stability in Markov decision processes. 28th Annual ACM/IEEE Symposium. LICS:
Logic in Computer Science, 331–340.'
mla: Brázdil, Tomáš, et al. “Trading Performance for Stability in Markov Decision
Processes.” 28th Annual ACM/IEEE Symposium, IEEE, 2013, pp. 331–40, doi:10.1109/LICS.2013.39.
short: T. Brázdil, K. Chatterjee, V. Forejt, A. Kučera, in:, 28th Annual ACM/IEEE
Symposium, IEEE, 2013, pp. 331–340.
conference:
end_date: 2013-06-28
location: New Orleans, LA, United States
name: 'LICS: Logic in Computer Science'
start_date: 2013-06-25
date_created: 2018-12-11T11:56:53Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2023-09-20T11:15:30Z
day: '01'
department:
- _id: KrCh
doi: 10.1109/LICS.2013.39
ec_funded: 1
external_id:
arxiv:
- '1305.4103'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1305.4103
month: '08'
oa: 1
oa_version: Preprint
page: 331 - 340
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: 28th Annual ACM/IEEE Symposium
publication_status: published
publisher: IEEE
publist_id: '4622'
quality_controlled: '1'
related_material:
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relation: later_version
status: public
scopus_import: 1
status: public
title: Trading performance for stability in Markov decision processes
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...