---
_id: '12205'
abstract:
- lang: eng
text: "Background: This study seeks to evaluate the impact of breast cancer (BRCA)
gene status on tumor dissemination pattern, surgical outcome and survival in a
multicenter cohort of paired primary ovarian cancer (pOC) and recurrent ovarian
cancer (rOC).\r\n\r\nPatients and Methods: Medical records and follow-up data
from 190 patients were gathered retrospectively. All patients had surgery at pOC
and at least one further rOC surgery at four European high-volume centers. Patients
were divided into one cohort with confirmed mutation for BRCA1 and/or BRCA2 (BRCAmut)
and a second cohort with BRCA wild type or unknown (BRCAwt). Patterns of tumor
presentation, surgical outcome and survival data were analyzed between the two
groups.\r\n\r\nResults: Patients with BRCAmut disease were on average 4 years
younger and had significantly more tumor involvement upon diagnosis. Patients
with BRCAmut disease showed higher debulking rates at all stages. Multivariate
analysis showed that only patient age had significant predictive value for complete
tumor resection in pOC. At rOC, however, only BRCAmut status significantly correlated
with optimal debulking. Patients with BRCAmut disease showed significantly prolonged
overall survival (OS) by 24.3 months. Progression-free survival (PFS) was prolonged
in the BRCAmut group at all stages as well, reaching statistical significance
during recurrence.\r\n\r\nConclusions: Patients with BRCAmut disease showed a
more aggressive course of disease with earlier onset and more extensive tumor
dissemination at pOC. However, surgical outcome and OS were significantly better
in patients with BRCAmut disease compared with patients with BRCAwt disease. We
therefore propose to consider BRCAmut status in regard to patient selection for
cytoreductive surgery, especially in rOC."
acknowledgement: "E.I.B. is a Feodor Lynen fellow of the Humboldt Foundation and a
participant of the Charité Clinical Scientist Program funded by the Charité Universitätsmedizin
Berlin and the Berlin Institute of Health. This work was supported by European Commission’s
Seventh Framework Programme under grant agreement no. 279113 (OCTIPS; www.octips.eu).\r\nOpen
Access funding enabled and organized by Projekt DEAL."
article_processing_charge: No
article_type: original
author:
- first_name: Jacek
full_name: Glajzer, Jacek
last_name: Glajzer
- first_name: Dan Cacsire
full_name: Castillo-Tong, Dan Cacsire
last_name: Castillo-Tong
- first_name: Rolf
full_name: Richter, Rolf
last_name: Richter
- first_name: Ignace
full_name: Vergote, Ignace
last_name: Vergote
- first_name: Hagen
full_name: Kulbe, Hagen
last_name: Kulbe
- first_name: Adriaan
full_name: Vanderstichele, Adriaan
last_name: Vanderstichele
- first_name: Ilary
full_name: Ruscito, Ilary
last_name: Ruscito
- first_name: Fabian
full_name: Trillsch, Fabian
last_name: Trillsch
- first_name: Alexander
full_name: Mustea, Alexander
last_name: Mustea
- first_name: Caroline
full_name: Kreuzinger, Caroline
id: 382077BA-F248-11E8-B48F-1D18A9856A87
last_name: Kreuzinger
- first_name: Charlie
full_name: Gourley, Charlie
last_name: Gourley
- first_name: Hani
full_name: Gabra, Hani
last_name: Gabra
- first_name: Eliane T.
full_name: Taube, Eliane T.
last_name: Taube
- first_name: Oliver
full_name: Dorigo, Oliver
last_name: Dorigo
- first_name: David
full_name: Horst, David
last_name: Horst
- first_name: Carlotta
full_name: Keunecke, Carlotta
last_name: Keunecke
- first_name: Joanna
full_name: Baum, Joanna
last_name: Baum
- first_name: Timothy
full_name: Angelotti, Timothy
last_name: Angelotti
- first_name: Jalid
full_name: Sehouli, Jalid
last_name: Sehouli
- first_name: Elena Ioana
full_name: Braicu, Elena Ioana
last_name: Braicu
citation:
ama: 'Glajzer J, Castillo-Tong DC, Richter R, et al. Impact of BRCA mutation status
on tumor dissemination pattern, surgical outcome and patient survival in primary
and recurrent high-grade serous ovarian cancer: A multicenter retrospective study
by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) consortium.
Annals of Surgical Oncology. 2023;30:35-45. doi:10.1245/s10434-022-12459-3'
apa: 'Glajzer, J., Castillo-Tong, D. C., Richter, R., Vergote, I., Kulbe, H., Vanderstichele,
A., … Braicu, E. I. (2023). Impact of BRCA mutation status on tumor dissemination
pattern, surgical outcome and patient survival in primary and recurrent high-grade
serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer
Therapy-Innovative Models Prolong Survival (OCTIPS) consortium. Annals of Surgical
Oncology. Springer Nature. https://doi.org/10.1245/s10434-022-12459-3'
chicago: 'Glajzer, Jacek, Dan Cacsire Castillo-Tong, Rolf Richter, Ignace Vergote,
Hagen Kulbe, Adriaan Vanderstichele, Ilary Ruscito, et al. “Impact of BRCA Mutation
Status on Tumor Dissemination Pattern, Surgical Outcome and Patient Survival in
Primary and Recurrent High-Grade Serous Ovarian Cancer: A Multicenter Retrospective
Study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium.”
Annals of Surgical Oncology. Springer Nature, 2023. https://doi.org/10.1245/s10434-022-12459-3.'
ieee: 'J. Glajzer et al., “Impact of BRCA mutation status on tumor dissemination
pattern, surgical outcome and patient survival in primary and recurrent high-grade
serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer
Therapy-Innovative Models Prolong Survival (OCTIPS) consortium,” Annals of
Surgical Oncology, vol. 30. Springer Nature, pp. 35–45, 2023.'
ista: 'Glajzer J, Castillo-Tong DC, Richter R, Vergote I, Kulbe H, Vanderstichele
A, Ruscito I, Trillsch F, Mustea A, Kreuzinger C, Gourley C, Gabra H, Taube ET,
Dorigo O, Horst D, Keunecke C, Baum J, Angelotti T, Sehouli J, Braicu EI. 2023.
Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome
and patient survival in primary and recurrent high-grade serous ovarian cancer:
A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models
Prolong Survival (OCTIPS) consortium. Annals of Surgical Oncology. 30, 35–45.'
mla: 'Glajzer, Jacek, et al. “Impact of BRCA Mutation Status on Tumor Dissemination
Pattern, Surgical Outcome and Patient Survival in Primary and Recurrent High-Grade
Serous Ovarian Cancer: A Multicenter Retrospective Study by the Ovarian Cancer
Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium.” Annals of
Surgical Oncology, vol. 30, Springer Nature, 2023, pp. 35–45, doi:10.1245/s10434-022-12459-3.'
short: J. Glajzer, D.C. Castillo-Tong, R. Richter, I. Vergote, H. Kulbe, A. Vanderstichele,
I. Ruscito, F. Trillsch, A. Mustea, C. Kreuzinger, C. Gourley, H. Gabra, E.T.
Taube, O. Dorigo, D. Horst, C. Keunecke, J. Baum, T. Angelotti, J. Sehouli, E.I.
Braicu, Annals of Surgical Oncology 30 (2023) 35–45.
date_created: 2023-01-16T09:44:36Z
date_published: 2023-01-01T00:00:00Z
date_updated: 2023-09-05T15:18:37Z
day: '01'
ddc:
- '610'
department:
- _id: JoDa
doi: 10.1245/s10434-022-12459-3
external_id:
isi:
- '000852125500006'
file:
- access_level: open_access
checksum: 36a1200e1011f4b2155a8041d0308f34
content_type: application/pdf
creator: dernst
date_created: 2023-02-02T13:01:20Z
date_updated: 2023-02-02T13:01:20Z
file_id: '12490'
file_name: 2023_AnnalsSurgicalOncology_Glajzer.pdf
file_size: 365865
relation: main_file
success: 1
file_date_updated: 2023-02-02T13:01:20Z
has_accepted_license: '1'
intvolume: ' 30'
isi: 1
keyword:
- Oncology
- Surgery
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 35-45
publication: Annals of Surgical Oncology
publication_identifier:
eissn:
- 1534-4681
issn:
- 1068-9265
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '12115'
relation: other
status: public
scopus_import: '1'
status: public
title: 'Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome
and patient survival in primary and recurrent high-grade serous ovarian cancer:
A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models
Prolong Survival (OCTIPS) consortium'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 30
year: '2023'
...
---
_id: '12115'
acknowledgement: This work was supported by European Commission’s Seventh Framework
Programme under Grant Agreement No. 279113 (OCTIPS; www.octips.eu).
article_processing_charge: No
article_type: original
author:
- first_name: Jacek
full_name: Glajzer, Jacek
last_name: Glajzer
- first_name: Dan Cacsire
full_name: Castillo-Tong, Dan Cacsire
last_name: Castillo-Tong
- first_name: Rolf
full_name: Richter, Rolf
last_name: Richter
- first_name: Ignace
full_name: Vergote, Ignace
last_name: Vergote
- first_name: Hagen
full_name: Kulbe, Hagen
last_name: Kulbe
- first_name: Adriaan
full_name: Vanderstichele, Adriaan
last_name: Vanderstichele
- first_name: Ilary
full_name: Ruscito, Ilary
last_name: Ruscito
- first_name: Fabian
full_name: Trillsch, Fabian
last_name: Trillsch
- first_name: Alexander
full_name: Mustea, Alexander
last_name: Mustea
- first_name: Caroline
full_name: Kreuzinger, Caroline
id: 382077BA-F248-11E8-B48F-1D18A9856A87
last_name: Kreuzinger
- first_name: Charlie
full_name: Gourley, Charlie
last_name: Gourley
- first_name: Hani
full_name: Gabra, Hani
last_name: Gabra
- first_name: Eliane T.
full_name: Taube, Eliane T.
last_name: Taube
- first_name: Oliver
full_name: Dorigo, Oliver
last_name: Dorigo
- first_name: David
full_name: Horst, David
last_name: Horst
- first_name: Carlotta
full_name: Keunecke, Carlotta
last_name: Keunecke
- first_name: Joanna
full_name: Baum, Joanna
last_name: Baum
- first_name: Timothy
full_name: Angelotti, Timothy
last_name: Angelotti
- first_name: Jalid
full_name: Sehouli, Jalid
last_name: Sehouli
- first_name: Elena Ioana
full_name: Braicu, Elena Ioana
last_name: Braicu
citation:
ama: 'Glajzer J, Castillo-Tong DC, Richter R, et al. ASO Visual Abstract: Impact
of BRCA mutation status on tumor dissemination pattern, surgical outcome, and
patient survival in primary and recurrent high-grade serous ovarian cancer (HGSOC).
A multicenter, retrospective study of the ovarian cancer therapy—innovative models
prolong survival (OCTIPS) consortium. Annals of Surgical Oncology. 2023;30:46-47.
doi:10.1245/s10434-022-12681-z'
apa: 'Glajzer, J., Castillo-Tong, D. C., Richter, R., Vergote, I., Kulbe, H., Vanderstichele,
A., … Braicu, E. I. (2023). ASO Visual Abstract: Impact of BRCA mutation status
on tumor dissemination pattern, surgical outcome, and patient survival in primary
and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective
study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS)
consortium. Annals of Surgical Oncology. Springer Nature. https://doi.org/10.1245/s10434-022-12681-z'
chicago: 'Glajzer, Jacek, Dan Cacsire Castillo-Tong, Rolf Richter, Ignace Vergote,
Hagen Kulbe, Adriaan Vanderstichele, Ilary Ruscito, et al. “ASO Visual Abstract:
Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome,
and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer
(HGSOC). A Multicenter, Retrospective Study of the Ovarian Cancer Therapy—Innovative
Models Prolong Survival (OCTIPS) Consortium.” Annals of Surgical Oncology.
Springer Nature, 2023. https://doi.org/10.1245/s10434-022-12681-z.'
ieee: 'J. Glajzer et al., “ASO Visual Abstract: Impact of BRCA mutation status
on tumor dissemination pattern, surgical outcome, and patient survival in primary
and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective
study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS)
consortium,” Annals of Surgical Oncology, vol. 30. Springer Nature, pp.
46–47, 2023.'
ista: 'Glajzer J, Castillo-Tong DC, Richter R, Vergote I, Kulbe H, Vanderstichele
A, Ruscito I, Trillsch F, Mustea A, Kreuzinger C, Gourley C, Gabra H, Taube ET,
Dorigo O, Horst D, Keunecke C, Baum J, Angelotti T, Sehouli J, Braicu EI. 2023.
ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination pattern,
surgical outcome, and patient survival in primary and recurrent high-grade serous
ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian cancer
therapy—innovative models prolong survival (OCTIPS) consortium. Annals of Surgical
Oncology. 30, 46–47.'
mla: 'Glajzer, Jacek, et al. “ASO Visual Abstract: Impact of BRCA Mutation Status
on Tumor Dissemination Pattern, Surgical Outcome, and Patient Survival in Primary
and Recurrent High-Grade Serous Ovarian Cancer (HGSOC). A Multicenter, Retrospective
Study of the Ovarian Cancer Therapy—Innovative Models Prolong Survival (OCTIPS)
Consortium.” Annals of Surgical Oncology, vol. 30, Springer Nature, 2023,
pp. 46–47, doi:10.1245/s10434-022-12681-z.'
short: J. Glajzer, D.C. Castillo-Tong, R. Richter, I. Vergote, H. Kulbe, A. Vanderstichele,
I. Ruscito, F. Trillsch, A. Mustea, C. Kreuzinger, C. Gourley, H. Gabra, E.T.
Taube, O. Dorigo, D. Horst, C. Keunecke, J. Baum, T. Angelotti, J. Sehouli, E.I.
Braicu, Annals of Surgical Oncology 30 (2023) 46–47.
date_created: 2023-01-12T11:56:22Z
date_published: 2023-01-01T00:00:00Z
date_updated: 2023-09-05T15:18:36Z
day: '01'
department:
- _id: JoDa
doi: 10.1245/s10434-022-12681-z
external_id:
isi:
- '000879151800001'
intvolume: ' 30'
isi: 1
keyword:
- Oncology
- Surgery
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1245/s10434-022-12681-z
month: '01'
oa: 1
oa_version: Published Version
page: 46-47
publication: Annals of Surgical Oncology
publication_identifier:
eissn:
- 1534-4681
issn:
- 1068-9265
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '12205'
relation: other
status: public
scopus_import: '1'
status: public
title: 'ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination
pattern, surgical outcome, and patient survival in primary and recurrent high-grade
serous ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian
cancer therapy—innovative models prolong survival (OCTIPS) consortium'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 30
year: '2023'
...
---
_id: '12817'
abstract:
- lang: eng
text: 3D-reconstruction of living brain tissue down to individual synapse level
would create opportunities for decoding the dynamics and structure-function relationships
of the brain’s complex and dense information processing network. However, it has
been hindered by insufficient 3D-resolution, inadequate signal-to-noise-ratio,
and prohibitive light burden in optical imaging, whereas electron microscopy is
inherently static. Here we solved these challenges by developing an integrated
optical/machine learning technology, LIONESS (Live Information-Optimized Nanoscopy
Enabling Saturated Segmentation). It leverages optical modifications to stimulated
emission depletion (STED) microscopy in comprehensively, extracellularly labelled
tissue and prior information on sample structure via machine learning to simultaneously
achieve isotropic super-resolution, high signal-to-noise-ratio, and compatibility
with living tissue. This allows dense deep-learning-based instance segmentation
and 3D-reconstruction at synapse level incorporating molecular, activity, and
morphodynamic information. LIONESS opens up avenues for studying the dynamic functional
(nano-)architecture of living brain tissue.
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
- _id: PreCl
- _id: LifeSc
- _id: M-Shop
- _id: E-Lib
acknowledgement: 'We thank J. Vorlaufer, N. Agudelo, A. Wartak for microscope maintenance
and troubleshooting, C. Kreuzinger and A. Freeman for technical assistance, and
M. Šuplata for hardware control support, and Márcia Cunha dos Santos for initial
exploration of software. We thank Paul Henderson for advice on deep-learning training
and Michael Sixt, Scott Boyd, and Tamara Weiss for discussions and critical reading
of the manuscript. Luke Lavis (Janelia Research Campus) generously provided JF585-HaloTag
ligand. '
article_processing_charge: No
author:
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
citation:
ama: Danzl JG. Research data for the publication “Dense 4D nanoscale reconstruction
of living brain tissue.” 2023. doi:10.15479/AT:ISTA:12817
apa: Danzl, J. G. (2023). Research data for the publication “Dense 4D nanoscale
reconstruction of living brain tissue.” Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:12817
chicago: Danzl, Johann G. “Research Data for the Publication ‘Dense 4D Nanoscale
Reconstruction of Living Brain Tissue.’” Institute of Science and Technology Austria,
2023. https://doi.org/10.15479/AT:ISTA:12817.
ieee: J. G. Danzl, “Research data for the publication ‘Dense 4D nanoscale reconstruction
of living brain tissue.’” Institute of Science and Technology Austria, 2023.
ista: Danzl JG. 2023. Research data for the publication ‘Dense 4D nanoscale reconstruction
of living brain tissue’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:12817.
mla: Danzl, Johann G. Research Data for the Publication “Dense 4D Nanoscale Reconstruction
of Living Brain Tissue.” Institute of Science and Technology Austria, 2023,
doi:10.15479/AT:ISTA:12817.
short: J.G. Danzl, (2023).
contributor:
- first_name: Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Eder
id: 3FB91342-F248-11E8-B48F-1D18A9856A87
last_name: Miguel Villalba
- first_name: Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
- first_name: Julia
id: 46E28B80-F248-11E8-B48F-1D18A9856A87
last_name: Lyudchik
- first_name: Donglai
last_name: Wei
- first_name: Zudi
last_name: Lin
- first_name: Jake
id: 63836096-4690-11EA-BD4E-32803DDC885E
last_name: Watson
orcid: 0000-0002-8698-3823
- first_name: Jakob
last_name: Troidl
- first_name: Johanna
last_name: Beyer
- first_name: Yoav
id: 43DF3136-F248-11E8-B48F-1D18A9856A87
last_name: Ben Simon
- first_name: Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Wiebke
id: 425C1CE8-F248-11E8-B48F-1D18A9856A87
last_name: Jahr
- first_name: Alban
id: 9ac8f577-2357-11eb-997a-e566c5550886
last_name: Cenameri
- first_name: Johannes
last_name: Broichhagen
- first_name: 'Seth G. N. '
last_name: Grant
- first_name: Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Hanspeter
last_name: Pfister
- first_name: Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
date_created: 2023-04-07T11:37:40Z
date_published: 2023-05-19T00:00:00Z
date_updated: 2024-01-10T08:37:48Z
day: '19'
ddc:
- '570'
department:
- _id: JoDa
doi: 10.15479/AT:ISTA:12817
file:
- access_level: open_access
checksum: c1819889e72ec86ee1bba809e19739e0
content_type: text/plain
creator: jdanzl
date_created: 2023-05-18T17:06:12Z
date_updated: 2023-05-18T17:06:12Z
file_id: '13030'
file_name: Readme.txt
file_size: 651
relation: main_file
success: 1
- access_level: open_access
checksum: 8f6259fc5128ffcc0cd89d25d51995c1
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T19:51:52Z
date_updated: 2023-05-18T19:51:52Z
file_id: '13031'
file_name: Fig1a_LIONESS.tif
file_size: 347448884
relation: main_file
success: 1
- access_level: open_access
checksum: 204e8ef763b5a122fa95a594f5217d83
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:48:26Z
date_updated: 2023-05-18T16:48:26Z
file_id: '13029'
file_name: Fig_1b.tif
file_size: 91626
relation: main_file
success: 1
- access_level: open_access
checksum: dc521a4e6e80a57c100a06ba1e87c766
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:48:26Z
date_updated: 2023-05-18T16:48:26Z
file_id: '13028'
file_name: Fig_1c.tif
file_size: 90300
relation: main_file
success: 1
- access_level: open_access
checksum: 56d3d5dbe7e1f54dbecc32ad2d2cc6df
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:00:06Z
date_updated: 2023-05-18T16:00:06Z
file_id: '13022'
file_name: Figure2a_low_exposure_input.tif
file_size: 18391928
relation: main_file
success: 1
- access_level: open_access
checksum: 2c30dbd6c4db079f7fdc2eaeea5f9710
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:59:30Z
date_updated: 2023-05-18T15:59:30Z
file_id: '13021'
file_name: Figure2a_LIONESS.tif
file_size: 18392017
relation: main_file
success: 1
- access_level: open_access
checksum: 799868024bf734fecaf36f4ffd843ed2
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:58:54Z
date_updated: 2023-05-18T15:58:54Z
file_id: '13020'
file_name: Figure2a_merge_LIONESS_EGFP.tif
file_size: 36785440
relation: main_file
success: 1
- access_level: open_access
checksum: 522fe0fe505e437d6f637f9b8059dfaa
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:44:45Z
date_updated: 2023-05-18T16:44:45Z
file_id: '13025'
file_name: Fig2c_LIONESS.tif
file_size: 670051576
relation: main_file
success: 1
- access_level: open_access
checksum: c9c0d873341d2f974ba799fa71a1b789
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:23:10Z
date_updated: 2023-05-18T16:23:10Z
file_id: '13024'
file_name: Fig2de_LIONESS_1.tif
file_size: 412478217
relation: main_file
success: 1
- access_level: open_access
checksum: ff86ad8642c56ba1c67c814e20925a85
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T19:48:02Z
date_updated: 2023-05-18T19:48:02Z
file_id: '13032'
file_name: Fig2de_LIONESS_2.tif
file_size: 637360217
relation: main_file
success: 1
- access_level: open_access
checksum: 32681bd33673088193fad9f9c7b79090
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T14:39:05Z
date_updated: 2023-05-18T14:39:05Z
file_id: '12995'
file_name: Fig_3_LIONESS.zip
file_size: 46563159
relation: main_file
success: 1
- access_level: open_access
checksum: 17239ed0f54ac7495e2b1daa5d0864ef
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T15:04:40Z
date_updated: 2023-05-18T15:04:40Z
file_id: '13001'
file_name: Fig_4_LIONESS_synaptic_markers.zip
file_size: 29159397
relation: main_file
success: 1
- access_level: open_access
checksum: c060c898f2bf93312a4c07dfdcb745cb
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T14:58:09Z
date_updated: 2023-05-18T14:58:09Z
file_id: '12997'
file_name: Fig_5a_time_series_Ca2+_imaging.zip
file_size: 16563855
relation: main_file
success: 1
- access_level: open_access
checksum: 85b4c0cd099212ecf0beec3a78bb35c5
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:55:44Z
date_updated: 2023-05-18T15:55:44Z
file_id: '13017'
file_name: Fig5b_LIONESS_T1.tif
file_size: 30632526
relation: main_file
success: 1
- access_level: open_access
checksum: eb83649a0ebc2f5ea7a0308324ebf308
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:57:40Z
date_updated: 2023-05-18T15:57:40Z
file_id: '13018'
file_name: Fig5b_LIONESS_T2.tif
file_size: 57634426
relation: main_file
success: 1
- access_level: open_access
checksum: 40a2d93a34f83ce37043d8414d981b3d
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:14:33Z
date_updated: 2023-05-18T15:14:33Z
file_id: '13005'
file_name: Extended_Data_Figure 3a_low_exposure.tif
file_size: 12512676
relation: main_file
success: 1
- access_level: open_access
checksum: 516521bb400f5c058184994b57165f8b
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:15:01Z
date_updated: 2023-05-18T15:15:01Z
file_id: '13006'
file_name: Extended_Data_Figure 3a_high_exposure.tif
file_size: 12512678
relation: main_file
success: 1
- access_level: open_access
checksum: 1d3a21970307de2d84b614985ec0706d
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:17:08Z
date_updated: 2023-05-18T15:17:08Z
file_id: '13007'
file_name: Extended_Data_Figure 3a_restored.tif
file_size: 50038242
relation: main_file
success: 1
- access_level: open_access
checksum: 441575853bf667ed89cc218079cc397b
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:56:57Z
date_updated: 2023-05-18T15:56:57Z
file_id: '13016'
file_name: Extended_Data_Figure 3b_example dataset_low_exposure_input.tif
file_size: 68298045
relation: main_file
success: 1
- access_level: open_access
checksum: e499355760270e14bcf12bdc7960bd7a
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:54:43Z
date_updated: 2023-05-18T15:54:43Z
file_id: '13015'
file_name: Extended_Data_Figure 3b_example dataset_merge_LIONESS_EGFP.tif
file_size: 136597524
relation: main_file
success: 1
- access_level: open_access
checksum: add9f1adc6763091233dbe8504f1c396
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:50:19Z
date_updated: 2023-05-18T15:50:19Z
file_id: '13014'
file_name: Extended_Data_Figure 3b_dataset_1_merge_LIONESS_EGFP.tif
file_size: 76103800
relation: main_file
success: 1
- access_level: open_access
checksum: 311719efb1c68d7243be557b779173f2
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:51:20Z
date_updated: 2023-05-18T15:51:20Z
file_id: '13013'
file_name: Extended_Data_Figure 3b_dataset_2_merge_LIONESS_EGFP.tif
file_size: 49810007
relation: main_file
success: 1
- access_level: open_access
checksum: 8d5d9d859f8d099bb3b877c4e455f699
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:32:55Z
date_updated: 2023-05-18T15:32:55Z
file_id: '13010'
file_name: Extended_Data_Figure 3b_dataset_3_merge_LIONESS_EGFP.tif
file_size: 169060658
relation: main_file
success: 1
- access_level: open_access
checksum: 79eca23cc5e2fc1fe26e03e1bba2e90f
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:47:03Z
date_updated: 2023-05-18T15:47:03Z
file_id: '13011'
file_name: Extended_Data_Figure 3b_dataset_4_merge_LIONESS_EGFP.tif
file_size: 169060658
relation: main_file
success: 1
- access_level: open_access
checksum: 107bf2e0f8a14b4bd0169c9104765171
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:47:47Z
date_updated: 2023-05-18T15:47:47Z
file_id: '13012'
file_name: Extended_Data_Figure 3b_dataset_5_merge_LIONESS_EGFP.tif
file_size: 244861000
relation: main_file
success: 1
- access_level: open_access
checksum: b71e4a090dd9a8048aee847ae47624f0
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T14:36:34Z
date_updated: 2023-05-18T14:36:34Z
file_id: '12994'
file_name: Extended_Data_Fig_4_LIONESS_TIF_stacks.zip
file_size: 76795968
relation: main_file
success: 1
- access_level: open_access
checksum: ea011c3d1966ba79a62e8cf775e595c5
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:09:31Z
date_updated: 2023-05-18T16:09:31Z
file_id: '13023'
file_name: Extended_Data_Fig5b.tif
file_size: 288330201
relation: main_file
success: 1
- access_level: open_access
checksum: 1c56b5b324b6270b0df72a77e1e9d6f1
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T15:21:29Z
date_updated: 2023-05-18T15:21:29Z
file_id: '13003'
file_name: Extended_Data_Fig_6_TIF_stacks.zip
file_size: 255976297
relation: main_file
success: 1
- access_level: open_access
checksum: 89150ebb0044ead282b9048e55cd3961
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T15:08:20Z
date_updated: 2023-05-18T15:08:20Z
file_id: '13002'
file_name: Extended_Data_Fig_7.zip
file_size: 70694476
relation: main_file
success: 1
- access_level: open_access
checksum: 81e79a6d4e6745dce63cdad94bfcdca4
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:46:36Z
date_updated: 2023-05-18T16:46:36Z
file_id: '13026'
file_name: Extended_Data_Fig_8b_T1.tif
file_size: 57634426
relation: main_file
success: 1
- access_level: open_access
checksum: 53da2b10969a185239b317be0ffa61ef
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:48:26Z
date_updated: 2023-05-18T16:48:26Z
file_id: '13027'
file_name: Extended_Data_Fig_8b_T2.tif
file_size: 57634426
relation: main_file
success: 1
- access_level: open_access
checksum: 9a97ccd3eb0c75a5c4f142e5dadc0fb3
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T15:02:09Z
date_updated: 2023-05-18T15:02:09Z
file_id: '12999'
file_name: Extended_Data_Fig_8c_png.zip
file_size: 2942961
relation: main_file
success: 1
- access_level: open_access
checksum: baaee60e695160118ea2167c6cb91775
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:17:38Z
date_updated: 2023-05-18T15:17:38Z
file_id: '13008'
file_name: Extended_Data_Fig9c_LIONESS.tif
file_size: 11949362
relation: main_file
success: 1
- access_level: open_access
checksum: 095a980d0d746bc2277b0586dbb9d652
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T15:02:00Z
date_updated: 2023-05-18T15:02:00Z
file_id: '12998'
file_name: Extended_Data_Fig_10_LIONESS_tif_xy_view.zip
file_size: 72553526
relation: main_file
success: 1
- access_level: open_access
checksum: 343b87c4842eab9e5086f248668dec84
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T14:22:43Z
date_updated: 2023-05-18T14:22:43Z
file_id: '12992'
file_name: Extended_Data_Fig_10_LIONESS_tif_xz_view.zip
file_size: 72906090
relation: main_file
success: 1
- access_level: open_access
checksum: c3d4970e5185f72cb89f36005e83a556
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T15:14:01Z
date_updated: 2023-05-18T15:14:01Z
file_id: '13004'
file_name: Supplementary_Fig_4.zip
file_size: 428208
relation: main_file
success: 1
- access_level: open_access
checksum: f451852622f8ba8992582ab9b57c49e5
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T14:32:29Z
date_updated: 2023-05-18T14:32:29Z
file_id: '12991'
file_name: Supplementary_Fig_8.zip
file_size: 230506869
relation: main_file
success: 1
- access_level: open_access
checksum: 874b524f38fad6b86be14326bb5aa706
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T16:00:15Z
date_updated: 2023-05-18T16:00:15Z
file_id: '13019'
file_name: Suppl_Fig_11_LIONESS.tif
file_size: 40406386
relation: main_file
success: 1
- access_level: open_access
checksum: 7ab5cc6c581c463d1d7e430399b8b384
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T14:57:18Z
date_updated: 2023-05-18T14:57:18Z
file_id: '12996'
file_name: Supplementary_Fig_12.zip
file_size: 357705621
relation: main_file
success: 1
- access_level: open_access
checksum: 9763330288c2d544a3e1d7bc12657ee8
content_type: image/tiff
creator: jdanzl
date_created: 2023-05-18T15:39:45Z
date_updated: 2023-05-18T15:39:45Z
file_id: '13009'
file_name: Supplementary_Fig_13.tif
file_size: 617709326
relation: main_file
success: 1
- access_level: open_access
checksum: 1e83b64e220694942ccf0ca70f17e33b
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T14:19:48Z
date_updated: 2023-05-18T14:19:48Z
file_id: '12990'
file_name: GCaMP_recording_overview_time_series_Suppl_Video_5.zip
file_size: 9387873
relation: main_file
success: 1
- access_level: open_access
checksum: fc7208299e6393e69b31a0051fa5ac2e
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T15:13:55Z
date_updated: 2023-05-18T15:13:55Z
file_id: '12993'
file_name: CARE model.zip
file_size: 1218458059
relation: main_file
success: 1
- access_level: open_access
checksum: 47db2185ff2c6ba9b059c9b1a8882832
content_type: application/zip
creator: jdanzl
date_created: 2023-05-18T15:03:10Z
date_updated: 2023-05-18T15:03:10Z
file_id: '13000'
file_name: Segmentation model.zip
file_size: 19052980
relation: main_file
success: 1
file_date_updated: 2023-05-18T19:51:52Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-sa/4.0/
month: '05'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '13267'
relation: used_in_publication
status: public
status: public
title: Research data for the publication "Dense 4D nanoscale reconstruction of living
brain tissue"
tmp:
image: /images/cc_by_sa.png
legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
BY-SA 4.0)
short: CC BY-SA (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '13267'
abstract:
- lang: eng
text: Three-dimensional (3D) reconstruction of living brain tissue down to an individual
synapse level would create opportunities for decoding the dynamics and structure–function
relationships of the brain’s complex and dense information processing network;
however, this has been hindered by insufficient 3D resolution, inadequate signal-to-noise
ratio and prohibitive light burden in optical imaging, whereas electron microscopy
is inherently static. Here we solved these challenges by developing an integrated
optical/machine-learning technology, LIONESS (live information-optimized nanoscopy
enabling saturated segmentation). This leverages optical modifications to stimulated
emission depletion microscopy in comprehensively, extracellularly labeled tissue
and previous information on sample structure via machine learning to simultaneously
achieve isotropic super-resolution, high signal-to-noise ratio and compatibility
with living tissue. This allows dense deep-learning-based instance segmentation
and 3D reconstruction at a synapse level, incorporating molecular, activity and
morphodynamic information. LIONESS opens up avenues for studying the dynamic functional
(nano-)architecture of living brain tissue.
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
- _id: PreCl
- _id: E-Lib
- _id: LifeSc
- _id: M-Shop
acknowledgement: "We thank J. Vorlaufer, N. Agudelo and A. Wartak for microscope maintenance
and troubleshooting, C. Kreuzinger and A. Freeman for technical assistance, M. Šuplata
for hardware control support and M. Cunha dos Santos for initial exploration of
software. We\r\nthank P. Henderson for advice on deep-learning training and M. Sixt,
S. Boyd and T. Weiss for discussions and critical reading of the manuscript. L.
Lavis (Janelia Research Campus) generously provided the JF585-HaloTag ligand. We
acknowledge expert support by IST\r\nAustria’s scientific computing, imaging and
optics, preclinical, library and laboratory support facilities and by the Miba machine
shop. We gratefully acknowledge funding by the following sources: Austrian Science
Fund (F.W.F.) grant no. I3600-B27 (J.G.D.), grant no. DK W1232\r\n(J.G.D. and J.M.M.)
and grant no. Z 312-B27, Wittgenstein award (P.J.); the Gesellschaft für Forschungsförderung
NÖ grant no. LSC18-022 (J.G.D.); an ISTA Interdisciplinary project grant (J.G.D.
and B.B.); the European Union’s Horizon 2020 research and innovation programme,\r\nMarie-Skłodowska
Curie grant 665385 (J.M.M. and J.L.); the European Union’s Horizon 2020 research
and innovation programme, European Research Council grant no. 715767, MATERIALIZABLE
(B.B.); grant no. 715508, REVERSEAUTISM (G.N.); grant no. 695568, SYNNOVATE (S.G.N.G.);
and grant no. 692692, GIANTSYN (P.J.); the Simons\r\nFoundation Autism Research
Initiative grant no. 529085 (S.G.N.G.); the Wellcome Trust Technology Development
grant no. 202932 (S.G.N.G.); the Marie Skłodowska-Curie Actions Individual Fellowship
no. 101026635 under the EU Horizon 2020 program (J.F.W.);\r\nthe Human Frontier
Science Program postdoctoral fellowship LT000557/2018 (W.J.); and the National Science
Foundation grant no. IIS-1835231 (H.P.) and NCS-FO-2124179 (H.P.)."
article_processing_charge: Yes
article_type: original
author:
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Eder
full_name: Miguel Villalba, Eder
id: 3FB91342-F248-11E8-B48F-1D18A9856A87
last_name: Miguel Villalba
orcid: 0000-0001-5665-0430
- first_name: Julia M
full_name: Michalska, Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
orcid: 0000-0003-3862-1235
- first_name: Julia
full_name: Lyudchik, Julia
id: 46E28B80-F248-11E8-B48F-1D18A9856A87
last_name: Lyudchik
- first_name: Donglai
full_name: Wei, Donglai
last_name: Wei
- first_name: Zudi
full_name: Lin, Zudi
last_name: Lin
- first_name: Jake
full_name: Watson, Jake
id: 63836096-4690-11EA-BD4E-32803DDC885E
last_name: Watson
orcid: 0000-0002-8698-3823
- first_name: Jakob
full_name: Troidl, Jakob
last_name: Troidl
- first_name: Johanna
full_name: Beyer, Johanna
last_name: Beyer
- first_name: Yoav
full_name: Ben Simon, Yoav
id: 43DF3136-F248-11E8-B48F-1D18A9856A87
last_name: Ben Simon
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Wiebke
full_name: Jahr, Wiebke
id: 425C1CE8-F248-11E8-B48F-1D18A9856A87
last_name: Jahr
- first_name: Alban
full_name: Cenameri, Alban
id: 9ac8f577-2357-11eb-997a-e566c5550886
last_name: Cenameri
- first_name: Johannes
full_name: Broichhagen, Johannes
last_name: Broichhagen
- first_name: Seth G.N.
full_name: Grant, Seth G.N.
last_name: Grant
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Hanspeter
full_name: Pfister, Hanspeter
last_name: Pfister
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
citation:
ama: Velicky P, Miguel Villalba E, Michalska JM, et al. Dense 4D nanoscale reconstruction
of living brain tissue. Nature Methods. 2023;20:1256-1265. doi:10.1038/s41592-023-01936-6
apa: Velicky, P., Miguel Villalba, E., Michalska, J. M., Lyudchik, J., Wei, D.,
Lin, Z., … Danzl, J. G. (2023). Dense 4D nanoscale reconstruction of living brain
tissue. Nature Methods. Springer Nature. https://doi.org/10.1038/s41592-023-01936-6
chicago: Velicky, Philipp, Eder Miguel Villalba, Julia M Michalska, Julia Lyudchik,
Donglai Wei, Zudi Lin, Jake Watson, et al. “Dense 4D Nanoscale Reconstruction
of Living Brain Tissue.” Nature Methods. Springer Nature, 2023. https://doi.org/10.1038/s41592-023-01936-6.
ieee: P. Velicky et al., “Dense 4D nanoscale reconstruction of living brain
tissue,” Nature Methods, vol. 20. Springer Nature, pp. 1256–1265, 2023.
ista: Velicky P, Miguel Villalba E, Michalska JM, Lyudchik J, Wei D, Lin Z, Watson
J, Troidl J, Beyer J, Ben Simon Y, Sommer CM, Jahr W, Cenameri A, Broichhagen
J, Grant SGN, Jonas PM, Novarino G, Pfister H, Bickel B, Danzl JG. 2023. Dense
4D nanoscale reconstruction of living brain tissue. Nature Methods. 20, 1256–1265.
mla: Velicky, Philipp, et al. “Dense 4D Nanoscale Reconstruction of Living Brain
Tissue.” Nature Methods, vol. 20, Springer Nature, 2023, pp. 1256–65, doi:10.1038/s41592-023-01936-6.
short: P. Velicky, E. Miguel Villalba, J.M. Michalska, J. Lyudchik, D. Wei, Z. Lin,
J. Watson, J. Troidl, J. Beyer, Y. Ben Simon, C.M. Sommer, W. Jahr, A. Cenameri,
J. Broichhagen, S.G.N. Grant, P.M. Jonas, G. Novarino, H. Pfister, B. Bickel,
J.G. Danzl, Nature Methods 20 (2023) 1256–1265.
date_created: 2023-07-23T22:01:13Z
date_published: 2023-08-01T00:00:00Z
date_updated: 2024-01-10T08:37:48Z
day: '01'
department:
- _id: PeJo
- _id: GaNo
- _id: BeBi
- _id: JoDa
- _id: Bio
doi: 10.1038/s41592-023-01936-6
ec_funded: 1
external_id:
isi:
- '001025621500001'
pmid:
- '37429995'
intvolume: ' 20'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41592-023-01936-6
month: '08'
oa: 1
oa_version: Published Version
page: 1256-1265
pmid: 1
project:
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03600
name: Optical control of synaptic function via adhesion molecules
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
- _id: 23889792-32DE-11EA-91FC-C7463DDC885E
name: High content imaging to decode human immune cell interactions in health and
allergic disease
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
- _id: 25444568-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715508'
name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo
and in vitro Models
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9
call_identifier: H2020
grant_number: '101026635'
name: Synaptic computations of the hippocampal CA3 circuitry
- _id: 2668BFA0-B435-11E9-9278-68D0E5697425
grant_number: LT00057
name: High-speed 3D-nanoscopy to study the role of adhesion during 3D cell migration
publication: Nature Methods
publication_identifier:
eissn:
- 1548-7105
issn:
- 1548-7091
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/danzllab/LIONESS
record:
- id: '12817'
relation: research_data
status: public
- id: '14770'
relation: shorter_version
status: public
scopus_import: '1'
status: public
title: Dense 4D nanoscale reconstruction of living brain tissue
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2023'
...
---
_id: '14770'
abstract:
- lang: eng
text: We developed LIONESS, a technology that leverages improvements to optical
super-resolution microscopy and prior information on sample structure via machine
learning to overcome the limitations (in 3D-resolution, signal-to-noise ratio
and light exposure) of optical microscopy of living biological specimens. LIONESS
enables dense reconstruction of living brain tissue and morphodynamics visualization
at the nanoscale.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
citation:
ama: Danzl JG, Velicky P. LIONESS enables 4D nanoscale reconstruction of living
brain tissue. Nature Methods. 2023;20(8):1141-1142. doi:10.1038/s41592-023-01937-5
apa: Danzl, J. G., & Velicky, P. (2023). LIONESS enables 4D nanoscale reconstruction
of living brain tissue. Nature Methods. Springer Nature. https://doi.org/10.1038/s41592-023-01937-5
chicago: Danzl, Johann G, and Philipp Velicky. “LIONESS Enables 4D Nanoscale Reconstruction
of Living Brain Tissue.” Nature Methods. Springer Nature, 2023. https://doi.org/10.1038/s41592-023-01937-5.
ieee: J. G. Danzl and P. Velicky, “LIONESS enables 4D nanoscale reconstruction of
living brain tissue,” Nature Methods, vol. 20, no. 8. Springer Nature,
pp. 1141–1142, 2023.
ista: Danzl JG, Velicky P. 2023. LIONESS enables 4D nanoscale reconstruction of
living brain tissue. Nature Methods. 20(8), 1141–1142.
mla: Danzl, Johann G., and Philipp Velicky. “LIONESS Enables 4D Nanoscale Reconstruction
of Living Brain Tissue.” Nature Methods, vol. 20, no. 8, Springer Nature,
2023, pp. 1141–42, doi:10.1038/s41592-023-01937-5.
short: J.G. Danzl, P. Velicky, Nature Methods 20 (2023) 1141–1142.
date_created: 2024-01-10T08:07:15Z
date_published: 2023-08-01T00:00:00Z
date_updated: 2024-01-10T08:37:48Z
day: '01'
department:
- _id: JoDa
doi: 10.1038/s41592-023-01937-5
external_id:
isi:
- '001025621500002'
intvolume: ' 20'
isi: 1
issue: '8'
keyword:
- Cell Biology
- Molecular Biology
- Biochemistry
- Biotechnology
language:
- iso: eng
month: '08'
oa_version: None
page: 1141-1142
publication: Nature Methods
publication_identifier:
eissn:
- 1548-7105
issn:
- 1548-7091
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '13267'
relation: extended_version
status: public
scopus_import: '1'
status: public
title: LIONESS enables 4D nanoscale reconstruction of living brain tissue
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2023'
...
---
_id: '13126'
abstract:
- lang: eng
text: Mapping the complex and dense arrangement of cells and their connectivity
in brain tissue demands nanoscale spatial resolution imaging. Super-resolution
optical microscopy excels at visualizing specific molecules and individual cells
but fails to provide tissue context. Here, we developed Comprehensive Analysis
of Tissues across Scales (CATS), a technology to densely map brain tissue architecture
from millimeter regional to nanometer synaptic scales in diverse chemically fixed
brain preparations, including rodent and human. CATS uses fixation-compatible
extracellular labeling and optical imaging, including stimulated emission depletion
or expansion microscopy, to comprehensively delineate cellular structures. It
enables three-dimensional reconstruction of single synapses and mapping of synaptic
connectivity by identification and analysis of putative synaptic cleft regions.
Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed
and quantified the synaptic input and output structure of identified neurons.
We furthermore demonstrate applicability to clinically derived human tissue samples,
including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing
the cellular architecture of brain tissue in health and disease.
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
- _id: PreCl
- _id: LifeSc
- _id: M-Shop
- _id: E-Lib
acknowledgement: "We thank Jakob Vorlaufer, Nathalie Agudelo-Dueñas, Wiebke Jahr,
Andreas Wartak for microscope maintenance and troubleshooting, Caroline Kreuzinger,
Anna Freeman, and Irene Erber for technical assistance and Matthias Tomschik for
support with obtaining human samples. We gratefully acknowledge Eder Miguel for
setting up webKnossos and Marek Šuplata for computational support and hardware control.
We are grateful to Ryuichi Shigemoto and Bernd Bickel for generous support, and
Michael Sixt and Scott Boyd (Stanford University) for discussions and critical reading
of the manuscript. PSD95-HaloTag mice were kindly provided by Seth Grant (University
of Edinburgh). We acknowledge expert support by IST Austria’s scientific computing,
imaging and optics, preclinical, and lab support facilities, and by the Library
and Miba machine shop.\r\nWe gratefully acknowledge funding by the following sources:
\r\nAustrian Science Fund (FWF) grant I3600-B27 (JGD)\r\nAustrian Science Fund (FWF)
grant DK W1232 (JGD, JMM)\r\nAustrian Science Fund (FWF) grant Z 312-B27, Wittgenstein
award (PJ)\r\nAustrian Science Funds (FWF) projects I4685-B, I6565-B (SYNABS) and
DOC 33-B27 (RH)\r\nGesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022
(JGD)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European
Research Council (ERC) grant 715508 – REVERSEAUTISM (GN)\r\nEuropean Union’s Horizon
2020 research and innovation programme, European Research Council (ERC) grant 692692
– GIANTSYN (PJ)\r\nMarie Skłodowska-Curie Actions Fellowship GA no. 665385 under
the EU Horizon 2020 program (JMM, JL)\r\nMarie Skłodowska-Curie Actions Individual
Fellowship 101026635 under the EU Horizon 2020 program (JFW)"
article_processing_charge: No
author:
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
citation:
ama: Danzl JG. Research data for the publication “Imaging brain tissue architecture
across millimeter to nanometer scales.” 2023. doi:10.15479/AT:ISTA:13126
apa: Danzl, J. G. (2023). Research data for the publication “Imaging brain tissue
architecture across millimeter to nanometer scales.” Institute of Science and
Technology Austria. https://doi.org/10.15479/AT:ISTA:13126
chicago: Danzl, Johann G. “Research Data for the Publication ‘Imaging Brain Tissue
Architecture across Millimeter to Nanometer Scales.’” Institute of Science and
Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:13126.
ieee: J. G. Danzl, “Research data for the publication ‘Imaging brain tissue architecture
across millimeter to nanometer scales.’” Institute of Science and Technology Austria,
2023.
ista: Danzl JG. 2023. Research data for the publication ‘Imaging brain tissue architecture
across millimeter to nanometer scales’, Institute of Science and Technology Austria,
10.15479/AT:ISTA:13126.
mla: Danzl, Johann G. Research Data for the Publication “Imaging Brain Tissue
Architecture across Millimeter to Nanometer Scales.” Institute of Science
and Technology Austria, 2023, doi:10.15479/AT:ISTA:13126.
short: J.G. Danzl, (2023).
contributor:
- first_name: Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
- first_name: Julia
id: 46E28B80-F248-11E8-B48F-1D18A9856A87
last_name: Lyudchik
- first_name: Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Hana
id: ee3cb6ca-ec98-11ea-ae11-ff703e2254ed
last_name: Stefanickova
- first_name: Jake
id: 63836096-4690-11EA-BD4E-32803DDC885E
last_name: Watson
orcid: 0000-0002-8698-3823
- first_name: Alban
id: 9ac8f577-2357-11eb-997a-e566c5550886
last_name: Cenameri
- first_name: Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Nicole
id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
last_name: Amberg
orcid: 0000-0002-3183-8207
- first_name: Alessandro
id: 41CB84B2-F248-11E8-B48F-1D18A9856A87
last_name: Venturino
orcid: 0000-0003-2356-9403
- first_name: Karl
last_name: Roessler
- first_name: Thomas
last_name: Czech
- first_name: Romana
last_name: Höftberger
- first_name: Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
- first_name: Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
date_created: 2023-06-07T07:15:12Z
date_published: 2023-08-04T00:00:00Z
date_updated: 2024-02-21T12:18:19Z
day: '04'
ddc:
- '610'
department:
- _id: JoDa
- _id: SaSi
- _id: GaNo
- _id: PeJo
- _id: Bio
- _id: RySh
doi: 10.15479/AT:ISTA:13126
ec_funded: 1
file:
- access_level: open_access
checksum: 6f18ce9b89b47ce5abeb379869ff5c49
content_type: text/plain
creator: jdanzl
date_created: 2023-08-04T13:19:47Z
date_updated: 2023-08-04T13:19:47Z
file_id: '13961'
file_name: Readme_Michalska_2023.txt
file_size: 541
relation: main_file
success: 1
- access_level: open_access
checksum: 2098e8c5285c5e86cb69075e1b5dcf39
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:29Z
date_updated: 2023-08-03T11:29:29Z
file_id: '13482'
file_name: Fig1_b_top-left.tif
file_size: 64582744
relation: main_file
success: 1
- access_level: open_access
checksum: 9affab3dacf847096cc8e8d5ff99467e
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:28Z
date_updated: 2023-08-03T11:29:28Z
file_id: '13483'
file_name: Fig1_b_top-right.tif
file_size: 1442113
relation: main_file
success: 1
- access_level: open_access
checksum: d7fec0296123a17f6bcdbfee17411424
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:29Z
date_updated: 2023-08-03T11:29:29Z
file_id: '13484'
file_name: Fig1_c_1.tif
file_size: 40078276
relation: main_file
success: 1
- access_level: open_access
checksum: 5195a180c4f26a7adc994bad0b3c53c7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:29Z
date_updated: 2023-08-03T11:29:29Z
file_id: '13485'
file_name: Fig1_c_2.tif
file_size: 7984315
relation: main_file
success: 1
- access_level: open_access
checksum: df1105d8f41ebd5373cacc597ffa91f3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:29Z
date_updated: 2023-08-03T11:29:29Z
file_id: '13486'
file_name: Fig1_c_3.tif
file_size: 8693320
relation: main_file
success: 1
- access_level: open_access
checksum: 00edbb0c9f42032c830d2291ec55c4c0
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:30Z
date_updated: 2023-08-03T11:29:30Z
file_id: '13487'
file_name: Fig1_c_4.tif
file_size: 6003063
relation: main_file
success: 1
- access_level: open_access
checksum: a58399e98ec4b6506a5dae13e387f391
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:30Z
date_updated: 2023-08-03T11:29:30Z
file_id: '13488'
file_name: Fig1_d.tif
file_size: 24003063
relation: main_file
success: 1
- access_level: open_access
checksum: 699df4bc104df14607359678963b3d2d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:30Z
date_updated: 2023-08-03T11:29:30Z
file_id: '13489'
file_name: Fig1_e_zoom.tif
file_size: 18063
relation: main_file
success: 1
- access_level: open_access
checksum: ea7b1278da490d221fc7698fd6bc39a4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:29:30Z
date_updated: 2023-08-03T11:29:30Z
file_id: '13490'
file_name: Fig1_e.tif
file_size: 186813
relation: main_file
success: 1
- access_level: open_access
checksum: 37b05ef3a36b9f6bf4ec46199230874a
content_type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
creator: jdanzl
date_created: 2023-08-03T11:29:30Z
date_updated: 2023-08-03T11:29:30Z
file_id: '13491'
file_name: Fig1_f.xlsx
file_size: 17494
relation: main_file
success: 1
- access_level: open_access
checksum: 872eb3dc1a94afb26947a365bfae581a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:40:43Z
date_updated: 2023-08-03T11:40:43Z
file_id: '13492'
file_name: Fig2_a_1.tif
file_size: 816786862
relation: main_file
success: 1
- access_level: open_access
checksum: cab6f72d7d546a81c105c229747949ef
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:40:13Z
date_updated: 2023-08-03T11:40:13Z
file_id: '13493'
file_name: Fig2_a_2.tif
file_size: 8654692
relation: main_file
success: 1
- access_level: open_access
checksum: c85bc3ffe7f6bdf16a81290761ed6253
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:40:14Z
date_updated: 2023-08-03T11:40:14Z
file_id: '13494'
file_name: Fig2_a_3.tif
file_size: 8654692
relation: main_file
success: 1
- access_level: open_access
checksum: 5a3fd5484e566c34e210a4acb2b97791
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:40:24Z
date_updated: 2023-08-03T11:40:24Z
file_id: '13495'
file_name: Fig2_a_4.tif
file_size: 272262438
relation: main_file
success: 1
- access_level: open_access
checksum: ae5cbacf56e3fdf934a6d6fd489f5fe0
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:40:37Z
date_updated: 2023-08-03T11:40:37Z
file_id: '13496'
file_name: Fig2_a_5.tif
file_size: 272262438
relation: main_file
success: 1
- access_level: open_access
checksum: e6da436b83bbe3a34138b52e5de49d69
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:40:44Z
date_updated: 2023-08-03T11:40:44Z
file_id: '13497'
file_name: Fig2_a_6.tif
file_size: 204301228
relation: main_file
success: 1
- access_level: open_access
checksum: 855f0a0bcf5b3d7cc7d50561f2c8f625
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:40:49Z
date_updated: 2023-08-03T11:40:49Z
file_id: '13498'
file_name: Fig2_a_7-8.tif
file_size: 68094350
relation: main_file
success: 1
- access_level: open_access
checksum: ff709f9f8ebaa8cf50a4b2fca5ce9813
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T11:40:48Z
date_updated: 2023-08-03T11:40:48Z
file_id: '13499'
file_name: Fig2_a_roi.roi
file_size: 156
relation: main_file
success: 1
- access_level: open_access
checksum: ce9b774ff5163ebfa4e3fb162f4cfffe
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:41:37Z
date_updated: 2023-08-03T11:41:37Z
file_id: '13500'
file_name: Fig2_c-i_1_n2v.tif
file_size: 1036927887
relation: main_file
success: 1
- access_level: open_access
checksum: 21f1bb8d2a00c88bdd6febe6285acc2a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:41:25Z
date_updated: 2023-08-03T11:41:25Z
file_id: '13501'
file_name: Fig2_c-i_1.tif
file_size: 518519275
relation: main_file
success: 1
- access_level: open_access
checksum: 9af5b66b74c2ff4b2b99b0d94f2864e6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:42:48Z
date_updated: 2023-08-03T11:42:48Z
file_id: '13502'
file_name: Fig2_c-i_3_n2v.tif
file_size: 1444202302
relation: main_file
success: 1
- access_level: open_access
checksum: c83261e88821747b301197314d92f2b2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:42:57Z
date_updated: 2023-08-03T11:42:57Z
file_id: '13503'
file_name: Fig2_c-i_3.tif
file_size: 1075338708
relation: main_file
success: 1
- access_level: open_access
checksum: 5d1278ba4b7e085c0c186ea49fce535b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:05Z
date_updated: 2023-08-03T11:44:05Z
file_id: '13504'
file_name: Fig2_c-i_2_n2v.tif
file_size: 851145493
relation: main_file
success: 1
- access_level: open_access
checksum: 5aaf1eba65582cf437ff3ce753eba4d7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:43:47Z
date_updated: 2023-08-03T11:43:47Z
file_id: '13505'
file_name: Fig2_c-i_2.tif
file_size: 432099834
relation: main_file
success: 1
- access_level: open_access
checksum: ce9b774ff5163ebfa4e3fb162f4cfffe
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:41Z
date_updated: 2023-08-03T11:44:41Z
file_id: '13506'
file_name: Fig2_h_n2v.tif
file_size: 1036927887
relation: main_file
success: 1
- access_level: open_access
checksum: 21f1bb8d2a00c88bdd6febe6285acc2a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:36Z
date_updated: 2023-08-03T11:44:36Z
file_id: '13507'
file_name: Fig2_h.tif
file_size: 518519275
relation: main_file
success: 1
- access_level: open_access
checksum: b37f25a90ef42fa4358649fdd6b41f35
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:40Z
date_updated: 2023-08-03T11:44:40Z
file_id: '13508'
file_name: Fig2_j_1.tif
file_size: 19287397
relation: main_file
success: 1
- access_level: open_access
checksum: 50f0969c6c2c1209ff776bec4861030a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:41Z
date_updated: 2023-08-03T11:44:41Z
file_id: '13509'
file_name: Fig2_j_2.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: 2a8cc93471378ac4c3b640e4318d89eb
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:41Z
date_updated: 2023-08-03T11:44:41Z
file_id: '13510'
file_name: Fig2_j_3.tif
file_size: 19287392
relation: main_file
success: 1
- access_level: open_access
checksum: b90965d20133fea73c99050c32eb7695
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:42Z
date_updated: 2023-08-03T11:44:42Z
file_id: '13511'
file_name: Fig2_j_4.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: 568a1e0efaa62527b51e66a7aabfd05c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:43Z
date_updated: 2023-08-03T11:44:43Z
file_id: '13512'
file_name: Fig2_j_coCATS_N2V.tif
file_size: 19287339
relation: main_file
success: 1
- access_level: open_access
checksum: c70447cebe073dd78e0ac34ecc36ad85
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T11:44:44Z
date_updated: 2023-08-03T11:44:44Z
file_id: '13513'
file_name: Fig2_j_roi.roi
file_size: 148
relation: main_file
success: 1
- access_level: open_access
checksum: 505252cc4b443b76c2e41ecf5879a542
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:44:52Z
date_updated: 2023-08-03T11:44:52Z
file_id: '13514'
file_name: Fig3_a_n2v.tif
file_size: 316842690
relation: main_file
success: 1
- access_level: open_access
checksum: 35463183611e8ee4fba2025772c40eb2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:45:01Z
date_updated: 2023-08-03T11:45:01Z
file_id: '13515'
file_name: Fig3_a.tif
file_size: 172839057
relation: main_file
success: 1
- access_level: open_access
checksum: e0469102a87332b46904b4ba35b8fb2f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:45:05Z
date_updated: 2023-08-03T11:45:05Z
file_id: '13516'
file_name: Fig3_g_n2v.tif
file_size: 309407894
relation: main_file
success: 1
- access_level: open_access
checksum: 854c8fe02acd920f8e8f6a3173458e86
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:15Z
date_updated: 2023-08-03T11:51:15Z
file_id: '13517'
file_name: Fig4_a_MIP.tif
file_size: 11327792
relation: main_file
success: 1
- access_level: open_access
checksum: ab35811ffbe3f40733d0e054d9d6c4e6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:18Z
date_updated: 2023-08-03T11:51:18Z
file_id: '13518'
file_name: Fig4_c_dghilus_bouton2_n2v.tif
file_size: 106696700
relation: main_file
success: 1
- access_level: open_access
checksum: e3b6410d68e42004ef3857967707aeb3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:17Z
date_updated: 2023-08-03T11:51:17Z
file_id: '13519'
file_name: Fig4_c_dghilus_bouton2.tif
file_size: 53367287
relation: main_file
success: 1
- access_level: open_access
checksum: 9ef0e3f3ec6f0b7b2666e3a0d7e6f355
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:20Z
date_updated: 2023-08-03T11:51:20Z
file_id: '13520'
file_name: Fig4_c_dghilus_bouton5_n2v.tif
file_size: 103816699
relation: main_file
success: 1
- access_level: open_access
checksum: d5d846a4edaf0168ca6cc53d8cc39dde
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:21Z
date_updated: 2023-08-03T11:51:21Z
file_id: '13521'
file_name: Fig4_c_dghilus_bouton5.tif
file_size: 51927287
relation: main_file
success: 1
- access_level: open_access
checksum: 690a87182441c9742da2550189641e5a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:24Z
date_updated: 2023-08-03T11:51:24Z
file_id: '13522'
file_name: Fig4_c_stratum_bouton11_n2v.tif
file_size: 76391971
relation: main_file
success: 1
- access_level: open_access
checksum: 4dc575424729c5ba181bd9a3962d4781
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:23Z
date_updated: 2023-08-03T11:51:23Z
file_id: '13523'
file_name: Fig4_c_stratum_bouton11.tif
file_size: 38217920
relation: main_file
success: 1
- access_level: open_access
checksum: 9fdd51636928f45e8e534cc5a37a48ff
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:29Z
date_updated: 2023-08-03T11:51:29Z
file_id: '13524'
file_name: Fig4_c_stratum_bouton13_n2v.tif
file_size: 154149020
relation: main_file
success: 1
- access_level: open_access
checksum: 643169464252d67753ac6f8493668f34
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:28Z
date_updated: 2023-08-03T11:51:28Z
file_id: '13525'
file_name: Fig4_c_stratum_bouton13.tif
file_size: 77099447
relation: main_file
success: 1
- access_level: open_access
checksum: ab35811ffbe3f40733d0e054d9d6c4e6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:32Z
date_updated: 2023-08-03T11:51:32Z
file_id: '13526'
file_name: Fig4_d.tif
file_size: 106696700
relation: main_file
success: 1
- access_level: open_access
checksum: 9fdd51636928f45e8e534cc5a37a48ff
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:35Z
date_updated: 2023-08-03T11:51:35Z
file_id: '13527'
file_name: Fig4_e.tif
file_size: 154149020
relation: main_file
success: 1
- access_level: open_access
checksum: 5380d0a98e97d7d8462b38bd0a96644c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:32Z
date_updated: 2023-08-03T11:51:32Z
file_id: '13528'
file_name: Fig4_f_1_top.tif
file_size: 5986760
relation: main_file
success: 1
- access_level: open_access
checksum: 7d1309e806eb31588ebafcf40388e13f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:33Z
date_updated: 2023-08-03T11:51:33Z
file_id: '13529'
file_name: Fig4_f_2_top.tif
file_size: 6001178
relation: main_file
success: 1
- access_level: open_access
checksum: a71c80207655d508cbc7626bc144d7a1
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:33Z
date_updated: 2023-08-03T11:51:33Z
file_id: '13530'
file_name: Fig4_f_3_top.tif
file_size: 6023318
relation: main_file
success: 1
- access_level: open_access
checksum: 5d76b2ad7d7acbb1afa27cf52194b1cb
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:34Z
date_updated: 2023-08-03T11:51:34Z
file_id: '13531'
file_name: Fig4_f_4_top.tif
file_size: 6038186
relation: main_file
success: 1
- access_level: open_access
checksum: 9cee6b3387bd880843f2c6cdfa0d4a8d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:51:34Z
date_updated: 2023-08-03T11:51:34Z
file_id: '13532'
file_name: Fig4_f_5_top.tif
file_size: 2324158
relation: main_file
success: 1
- access_level: open_access
checksum: a48fc9e1bb2710cf28466ae6d2a20c19
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T11:51:34Z
date_updated: 2023-08-03T11:51:34Z
file_id: '13533'
file_name: Fig4_f_1_bottom.png
file_size: 1150264
relation: main_file
success: 1
- access_level: open_access
checksum: ff47ca30f814e17561974b73b0913a1a
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T11:51:34Z
date_updated: 2023-08-03T11:51:34Z
file_id: '13534'
file_name: Fig4_f_2_bottom.png
file_size: 1157424
relation: main_file
success: 1
- access_level: open_access
checksum: 2ea3fb8d79cee8ae9de7ca31d003910f
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T11:51:34Z
date_updated: 2023-08-03T11:51:34Z
file_id: '13535'
file_name: Fig4_f_3_bottom.png
file_size: 1152715
relation: main_file
success: 1
- access_level: open_access
checksum: d25e5ecf2f0c3be7c20a7e25a7a334b8
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T11:51:34Z
date_updated: 2023-08-03T11:51:34Z
file_id: '13536'
file_name: Fig4_f_4_bottom.png
file_size: 1105240
relation: main_file
success: 1
- access_level: open_access
checksum: 76535f569a57b967e378df89b7d2982a
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T11:51:35Z
date_updated: 2023-08-03T11:51:35Z
file_id: '13537'
file_name: Fig4_f_5_bottom.png
file_size: 1228157
relation: main_file
success: 1
- access_level: open_access
checksum: d46fefe73daa3ec08b847631e9de6828
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:52Z
date_updated: 2023-08-03T11:53:52Z
file_id: '13538'
file_name: Fig5_a_1.tif
file_size: 91181184
relation: main_file
success: 1
- access_level: open_access
checksum: 354c0ba876a33672eca37cd61dac7073
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:54Z
date_updated: 2023-08-03T11:53:54Z
file_id: '13539'
file_name: Fig5_a_2.tif
file_size: 176024124
relation: main_file
success: 1
- access_level: open_access
checksum: d07925040ef0c3c51edbdca8cf3ec1fa
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:53Z
date_updated: 2023-08-03T11:53:53Z
file_id: '13540'
file_name: Fig5_a_3.tif
file_size: 15812494
relation: main_file
success: 1
- access_level: open_access
checksum: 7c34b19a1764e2f501f11dcabd442ce2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:53Z
date_updated: 2023-08-03T11:53:53Z
file_id: '13541'
file_name: Fig5_a_4.tif
file_size: 11117689
relation: main_file
success: 1
- access_level: open_access
checksum: c49af4b96532e00b3a51574a2a94decb
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:53Z
date_updated: 2023-08-03T11:53:53Z
file_id: '13542'
file_name: Fig5_a_5.tif
file_size: 111665
relation: main_file
success: 1
- access_level: open_access
checksum: 1b42eadcdd71f2dc00d82784673aa577
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:54Z
date_updated: 2023-08-03T11:53:54Z
file_id: '13543'
file_name: Fig5_b_1.tif
file_size: 16676449
relation: main_file
success: 1
- access_level: open_access
checksum: 0d27266bf216f71fcb5496731ce76dd5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:54Z
date_updated: 2023-08-03T11:53:54Z
file_id: '13544'
file_name: Fig5_b_2-4.tif
file_size: 427651
relation: main_file
success: 1
- access_level: open_access
checksum: c4232930068a0a8f7c8a70ce0ea48dc2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:55Z
date_updated: 2023-08-03T11:53:55Z
file_id: '13545'
file_name: Fig5_c_1-3.tif
file_size: 11117705
relation: main_file
success: 1
- access_level: open_access
checksum: c9caad749be0ef04ef8013cfdb69f8fc
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:55Z
date_updated: 2023-08-03T11:53:55Z
file_id: '13546'
file_name: Fig5_c_2-4.tif
file_size: 254153
relation: main_file
success: 1
- access_level: open_access
checksum: 5c6d36b96bde1e090cc428b269aba6ec
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:54:14Z
date_updated: 2023-08-03T11:54:14Z
file_id: '13547'
file_name: Fig5_e_1.tif
file_size: 737290746
relation: main_file
success: 1
- access_level: open_access
checksum: f97632984b6a73e06cc0c8c947cdcc71
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:57Z
date_updated: 2023-08-03T11:53:57Z
file_id: '13548'
file_name: Fig5_e_2.tif
file_size: 31366288
relation: main_file
success: 1
- access_level: open_access
checksum: 8c471eeaa59008eed9e91afe5e1f1698
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:57Z
date_updated: 2023-08-03T11:53:57Z
file_id: '13549'
file_name: Fig5_e_3.tif
file_size: 1216304
relation: main_file
success: 1
- access_level: open_access
checksum: 31c10c3a1d874b5028e35e2dd8800a68
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:59Z
date_updated: 2023-08-03T11:53:59Z
file_id: '13550'
file_name: Fig5_g.tif
file_size: 35669193
relation: main_file
success: 1
- access_level: open_access
checksum: 0e9fe7b7ee06a630837e9d3c41b80e01
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:53:59Z
date_updated: 2023-08-03T11:53:59Z
file_id: '13551'
file_name: Fig5_h.tif
file_size: 7492349
relation: main_file
success: 1
- access_level: open_access
checksum: d25b3d04bb8364089cafdf8deb6846b6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:18Z
date_updated: 2023-08-03T11:59:18Z
file_id: '13552'
file_name: Fig6_a_1.tif
file_size: 121446390
relation: main_file
success: 1
- access_level: open_access
checksum: 4361e10db6ec48c2d4579ac089ff3ca3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:22Z
date_updated: 2023-08-03T11:59:22Z
file_id: '13553'
file_name: Fig6_a_2.tif
file_size: 264412158
relation: main_file
success: 1
- access_level: open_access
checksum: fe3a00ae75fb3388438e53ced92a9498
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:21Z
date_updated: 2023-08-03T11:59:21Z
file_id: '13554'
file_name: Fig6_a_3.tif
file_size: 57399051
relation: main_file
success: 1
- access_level: open_access
checksum: 4372c13d6dd2274aa749799b8e96bf06
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:21Z
date_updated: 2023-08-03T11:59:21Z
file_id: '13555'
file_name: Fig6_b_left.tif
file_size: 6003163
relation: main_file
success: 1
- access_level: open_access
checksum: f7ae4e50f2f4d414c598bddd691b722a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:21Z
date_updated: 2023-08-03T11:59:21Z
file_id: '13556'
file_name: Fig6_b_right.tif
file_size: 511265
relation: main_file
success: 1
- access_level: open_access
checksum: cde658a9ca666bdef1b29613ab72092d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:39Z
date_updated: 2023-08-03T11:59:39Z
file_id: '13557'
file_name: Fig6_c_n2v.tif
file_size: 467125933
relation: main_file
success: 1
- access_level: open_access
checksum: 57e73c1fedcee4bd8ab62518baa0e0e5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:36Z
date_updated: 2023-08-03T11:59:36Z
file_id: '13558'
file_name: Fig6_c.tif
file_size: 322251440
relation: main_file
success: 1
- access_level: open_access
checksum: 53175073b83ab569241ae64ef7f180b3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:38Z
date_updated: 2023-08-03T11:59:38Z
file_id: '13559'
file_name: Fig6_d_1.tif
file_size: 37641738
relation: main_file
success: 1
- access_level: open_access
checksum: af97423e1077af85465a5e39fa25d1e4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:40Z
date_updated: 2023-08-03T11:59:40Z
file_id: '13560'
file_name: Fig6_d_2.tif
file_size: 70596929
relation: main_file
success: 1
- access_level: open_access
checksum: f1fd7a9fa2a12a930fe35bdf53ba3ff7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:42Z
date_updated: 2023-08-03T11:59:42Z
file_id: '13561'
file_name: Fig6_d_3.tif
file_size: 15303146
relation: main_file
success: 1
- access_level: open_access
checksum: 95655df5cdb05f09912298de9a3711b4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:41Z
date_updated: 2023-08-03T11:59:41Z
file_id: '13562'
file_name: Fig6_d_4.tif
file_size: 893051
relation: main_file
success: 1
- access_level: open_access
checksum: 4d722b4e09ce617252d284f78ea2ee30
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:58Z
date_updated: 2023-08-03T11:59:58Z
file_id: '13563'
file_name: Fig6_e.tif
file_size: 381232200
relation: main_file
success: 1
- access_level: open_access
checksum: d1eda9599f422a614404dd112f0c3185
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T11:59:58Z
date_updated: 2023-08-03T11:59:58Z
file_id: '13564'
file_name: Fig6_f.tif
file_size: 345804470
relation: main_file
success: 1
- access_level: open_access
checksum: 1cd202570f964b78e1f55c987d5d5de1
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:00:08Z
date_updated: 2023-08-03T12:00:08Z
file_id: '13565'
file_name: Fig6_g.tif
file_size: 346119927
relation: main_file
success: 1
- access_level: open_access
checksum: 78cbf1906ff8746ed524c62f8f580f52
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:00:02Z
date_updated: 2023-08-03T12:00:02Z
file_id: '13566'
file_name: Fig6_h.tif
file_size: 7064977
relation: main_file
success: 1
- access_level: open_access
checksum: 21635ce59f1ae5a334aaad3f4c0b171c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:00:03Z
date_updated: 2023-08-03T12:00:03Z
file_id: '13567'
file_name: Fig6_i.tif
file_size: 7110129
relation: main_file
success: 1
- access_level: open_access
checksum: 704962856f2a024ce1f321a1785556e3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:00:07Z
date_updated: 2023-08-03T12:00:07Z
file_id: '13568'
file_name: Fig6_j.tif
file_size: 110297540
relation: main_file
success: 1
- access_level: open_access
checksum: 4b74ba5ae1e2bb2201bf51c74d733268
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:00:07Z
date_updated: 2023-08-03T12:00:07Z
file_id: '13569'
file_name: Fig6_k.tif
file_size: 11117689
relation: main_file
success: 1
- access_level: open_access
checksum: a8efa3007df4e9e0f80c7a2bbc451178
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13570'
file_name: Extdata_01_a_1.tif
file_size: 1287107
relation: main_file
success: 1
- access_level: open_access
checksum: 7f24b6c84ce96a67347eb5ef4c43fac1
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13571'
file_name: Extdata_01_a_2.tif
file_size: 58307
relation: main_file
success: 1
- access_level: open_access
checksum: fa7ae4eefc11b9b60c4ab80f6e839b73
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13572'
file_name: Extdata_01_a_3.tif
file_size: 1283209
relation: main_file
success: 1
- access_level: open_access
checksum: cec9a5eb87f1b56e64626a00c6d0e53d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13573'
file_name: Extdata_01_a_4.tif
file_size: 54409
relation: main_file
success: 1
- access_level: open_access
checksum: 450e4786d66d5059028420153908a4dc
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13574'
file_name: Extdata_01_c_1.png
file_size: 2431
relation: main_file
success: 1
- access_level: open_access
checksum: feb758609b399cf644dd3ae7cd75fb96
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13575'
file_name: Extdata_01_c_2.png
file_size: 612
relation: main_file
success: 1
- access_level: open_access
checksum: 52f43300a50f83f9a6ff1409324086ee
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13576'
file_name: Extdata_01_d_1.tif
file_size: 433981
relation: main_file
success: 1
- access_level: open_access
checksum: 28925dcf8792f524e286beb16b0c532c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13577'
file_name: Extdata_01_d_2.tif
file_size: 19649
relation: main_file
success: 1
- access_level: open_access
checksum: c93b2f0426c80d18e252435f1e146568
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13578'
file_name: Extdata_01_d_3.tif
file_size: 433981
relation: main_file
success: 1
- access_level: open_access
checksum: c0ed722a768001431f47646ef98c44da
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13579'
file_name: Extdata_01_d_4.tif
file_size: 19649
relation: main_file
success: 1
- access_level: open_access
checksum: db9d386276b985b8e702f797e910bd0b
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13580'
file_name: Extdata_01_f_1.png
file_size: 4752
relation: main_file
success: 1
- access_level: open_access
checksum: 244f6645d191c50d997c0dc6a15535ec
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T12:05:41Z
date_updated: 2023-08-03T12:05:41Z
file_id: '13581'
file_name: Extdata_01_f_2.png
file_size: 2698
relation: main_file
success: 1
- access_level: open_access
checksum: 3d6100b836d850b38e66e0f5a7919495
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:07:27Z
date_updated: 2023-08-03T12:07:27Z
file_id: '13582'
file_name: Extdata_02_a.tif
file_size: 24003247
relation: main_file
success: 1
- access_level: open_access
checksum: 3cd6a3b7bf2061cf5c7810c0001236e5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:07:27Z
date_updated: 2023-08-03T12:07:27Z
file_id: '13583'
file_name: Extdata_02_b.tif
file_size: 1164723
relation: main_file
success: 1
- access_level: open_access
checksum: d87c82d663ffea379cc86c56981e2e16
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:10:32Z
date_updated: 2023-08-03T12:10:32Z
file_id: '13584'
file_name: Extdata_03_SYPH1_xy_1.tif
file_size: 7109763
relation: main_file
success: 1
- access_level: open_access
checksum: a3703d0d26393578d4ba466681fc6be8
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:10:32Z
date_updated: 2023-08-03T12:10:32Z
file_id: '13585'
file_name: Extdata_03_SYPH1_xz_1-2.tif
file_size: 27791
relation: main_file
success: 1
- access_level: open_access
checksum: f653ac7d531cf9896cbd6a9edf2a7759
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:10:32Z
date_updated: 2023-08-03T12:10:32Z
file_id: '13586'
file_name: Extdata_03_SYPH1_xz_3-4.tif
file_size: 27721
relation: main_file
success: 1
- access_level: open_access
checksum: 04edbb337df4d5470e033a4f53c07300
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:10:33Z
date_updated: 2023-08-03T12:10:33Z
file_id: '13587'
file_name: Extdata_03_SYPH1_xz_n2v.tif
file_size: 57657482
relation: main_file
success: 1
- access_level: open_access
checksum: 09e1fe2dd3a1e8349693fda55d0985ca
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:10:34Z
date_updated: 2023-08-03T12:10:34Z
file_id: '13588'
file_name: Extdata_03_SYPH1_xz.tif
file_size: 57657527
relation: main_file
success: 1
- access_level: open_access
checksum: 458f8d486cb63876c6664cde4a9be27c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:12:25Z
date_updated: 2023-08-03T12:12:25Z
file_id: '13589'
file_name: Extdata_03_SYP1_xy_1.tif
file_size: 7109763
relation: main_file
success: 1
- access_level: open_access
checksum: e2dfccc882d85b660d65a596e1a8cbac
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:12:25Z
date_updated: 2023-08-03T12:12:25Z
file_id: '13590'
file_name: Extdata_03_SYP1_xy_2-3.tif
file_size: 72963
relation: main_file
success: 1
- access_level: open_access
checksum: a331be6052c68cc027cdb79f15447d9a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:12:25Z
date_updated: 2023-08-03T12:12:25Z
file_id: '13591'
file_name: Extdata_03_SYP1_xz_1-2.tif
file_size: 27724
relation: main_file
success: 1
- access_level: open_access
checksum: 4de626b035b43feaacd923fca411e6a2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:12:25Z
date_updated: 2023-08-03T12:12:25Z
file_id: '13592'
file_name: Extdata_03_SYP1_xz_3-4.tif
file_size: 27724
relation: main_file
success: 1
- access_level: open_access
checksum: d8076e927a074f024924d9bdb6fdd5e6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:12:30Z
date_updated: 2023-08-03T12:12:30Z
file_id: '13593'
file_name: Extdata_03_SYP1_xz_n2v.tif
file_size: 214613644
relation: main_file
success: 1
- access_level: open_access
checksum: 79cf7d0f450c397caa877dd06b52f8df
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:12:30Z
date_updated: 2023-08-03T12:12:30Z
file_id: '13594'
file_name: Extdata_03_SYP1_xz.tif
file_size: 214613687
relation: main_file
success: 1
- access_level: open_access
checksum: 60ac6ea988d9b8bdaba2f09e0e1ef370
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:14:29Z
date_updated: 2023-08-03T12:14:29Z
file_id: '13595'
file_name: Extdata03_VAMP2_xy_1.tif
file_size: 7109747
relation: main_file
success: 1
- access_level: open_access
checksum: 92bf312da2dd356aa4fc9a0e7d811af2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:14:29Z
date_updated: 2023-08-03T12:14:29Z
file_id: '13596'
file_name: Extdata03_VAMP2_xy_2-3.tif
file_size: 72947
relation: main_file
success: 1
- access_level: open_access
checksum: 9319e293092eeee24e3c658fc178af1a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:14:29Z
date_updated: 2023-08-03T12:14:29Z
file_id: '13597'
file_name: Extdata03_VAMP2_xz_1-2.tif
file_size: 27724
relation: main_file
success: 1
- access_level: open_access
checksum: a627d7fd9a89bdde968e6d9bff846254
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:14:29Z
date_updated: 2023-08-03T12:14:29Z
file_id: '13598'
file_name: Extdata03_VAMP2_xz_3-4.tif
file_size: 27708
relation: main_file
success: 1
- access_level: open_access
checksum: 7a5363a185edce59ce57535f7d855092
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:14:32Z
date_updated: 2023-08-03T12:14:32Z
file_id: '13599'
file_name: Extdata03_VAMP2_xz_n2v.tif
file_size: 102457485
relation: main_file
success: 1
- access_level: open_access
checksum: 8e7fc4d00fff8ec6d9340e969f37e176
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:14:32Z
date_updated: 2023-08-03T12:14:32Z
file_id: '13600'
file_name: Extdata03_VAMP2_xz.tif
file_size: 102457527
relation: main_file
success: 1
- access_level: open_access
checksum: be17472f73ed8cd02a700b861f1dbac0
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:16:08Z
date_updated: 2023-08-03T12:16:08Z
file_id: '13601'
file_name: Extdata04_VGLUT_xy_1.tif
file_size: 11117763
relation: main_file
success: 1
- access_level: open_access
checksum: dbc3ec477f491ce3e98ab40475bd90ca
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:16:08Z
date_updated: 2023-08-03T12:16:08Z
file_id: '13602'
file_name: Extdata04_VGLUT_xy_2-3.tif
file_size: 72947
relation: main_file
success: 1
- access_level: open_access
checksum: 8ee877e6b843bb0e38febb0481962d69
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:16:08Z
date_updated: 2023-08-03T12:16:08Z
file_id: '13603'
file_name: Extdata04_VGLUT_xz_1-2.tif
file_size: 53367
relation: main_file
success: 1
- access_level: open_access
checksum: 9873f54d50955a2c204d0559c87aa13d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:16:08Z
date_updated: 2023-08-03T12:16:08Z
file_id: '13604'
file_name: Extdata04_VGLUT_xz_3-4.tif
file_size: 53358
relation: main_file
success: 1
- access_level: open_access
checksum: 8eda08ae5981fcfa3758d0320b1923af
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:16:11Z
date_updated: 2023-08-03T12:16:11Z
file_id: '13605'
file_name: Extdata04_VGLUT_xz_n2v.tif
file_size: 144076208
relation: main_file
success: 1
- access_level: open_access
checksum: bc0b10229d498f60996a5b05cb87c428
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:16:10Z
date_updated: 2023-08-03T12:16:10Z
file_id: '13606'
file_name: Extdata04_VGLUT_xz.tif
file_size: 72071440
relation: main_file
success: 1
- access_level: open_access
checksum: e8d093ce7d98ea5647d8a80e3084c40b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:32:32Z
date_updated: 2023-08-03T12:32:32Z
file_id: '13607'
file_name: Extdata03_VGAT_xy_1.tif
file_size: 7109763
relation: main_file
success: 1
- access_level: open_access
checksum: 36590ca7a586de7ad76d3ad659c38995
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:32:32Z
date_updated: 2023-08-03T12:32:32Z
file_id: '13608'
file_name: Extdata03_VGAT_xy_2-3.tif
file_size: 72947
relation: main_file
success: 1
- access_level: open_access
checksum: 3914c7709f69d4d18f23a9fb6dc64572
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:32:32Z
date_updated: 2023-08-03T12:32:32Z
file_id: '13609'
file_name: Extdata03_VGAT_xz_1-2.tif
file_size: 53355
relation: main_file
success: 1
- access_level: open_access
checksum: fa98aa521adaefb9e4476fe519e88e59
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:32:32Z
date_updated: 2023-08-03T12:32:32Z
file_id: '13610'
file_name: Extdata03_VGAT_xz_3-4.tif
file_size: 53339
relation: main_file
success: 1
- access_level: open_access
checksum: cd6f384c51756977e37f45043c913252
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:32:36Z
date_updated: 2023-08-03T12:32:36Z
file_id: '13611'
file_name: Extdata03_VGAT_xz_n2v.tif
file_size: 204861338
relation: main_file
success: 1
- access_level: open_access
checksum: fb7e46feda5ac07877a91ad963da0e31
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:32:35Z
date_updated: 2023-08-03T12:32:35Z
file_id: '13612'
file_name: Extdata03_VGAT_xz.tif
file_size: 102457527
relation: main_file
success: 1
- access_level: open_access
checksum: fe033e0a377d391cd8e4af04987d9900
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T12:36:46Z
date_updated: 2023-08-03T12:36:46Z
file_id: '13613'
file_name: Extdata04_MUNC_xy_1.png
file_size: 4348932
relation: main_file
success: 1
- access_level: open_access
checksum: 771d8e2b9192b6620f54ab30e4fad594
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:35:58Z
date_updated: 2023-08-03T12:35:58Z
file_id: '13614'
file_name: Extdata04_MUNC_xy_2-3.tif
file_size: 72947
relation: main_file
success: 1
- access_level: open_access
checksum: 4256d8f06fa2077b352776cf76b46618
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:35:58Z
date_updated: 2023-08-03T12:35:58Z
file_id: '13615'
file_name: Extdata04_MUNC_xz_1-2.tif
file_size: 53435
relation: main_file
success: 1
- access_level: open_access
checksum: 0b9365638c81d545e773170cf04b04b8
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:35:58Z
date_updated: 2023-08-03T12:35:58Z
file_id: '13616'
file_name: Extdata04_MUNC_xz_3-4.tif
file_size: 55941
relation: main_file
success: 1
- access_level: open_access
checksum: 9fa62688dab03c592cec47bf5d1c304d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:36:04Z
date_updated: 2023-08-03T12:36:04Z
file_id: '13617'
file_name: Extdata04_MUNC_xz_n2v.tif
file_size: 204861404
relation: main_file
success: 1
- access_level: open_access
checksum: 39f710080a26136dbbe4c8916b434c65
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:36:02Z
date_updated: 2023-08-03T12:36:02Z
file_id: '13618'
file_name: Extdata04_MUNC_xz.tif
file_size: 102457527
relation: main_file
success: 1
- access_level: open_access
checksum: eaabc8112645a73f4326e621b4e6ad0a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:38:39Z
date_updated: 2023-08-03T12:38:39Z
file_id: '13619'
file_name: Extdata04_BASSOON_xy_1.tif
file_size: 11117757
relation: main_file
success: 1
- access_level: open_access
checksum: 15f624d29c473ce6e0ae7e466efc059a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:38:39Z
date_updated: 2023-08-03T12:38:39Z
file_id: '13620'
file_name: Extdata04_BASSOON_xy_2-3.tif
file_size: 74041
relation: main_file
success: 1
- access_level: open_access
checksum: 1cb4b4d219767a30072c804a07140240
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:38:39Z
date_updated: 2023-08-03T12:38:39Z
file_id: '13621'
file_name: Extdata04_BASSOON_xz_1-2.tif
file_size: 53435
relation: main_file
success: 1
- access_level: open_access
checksum: 1bac9c192da9375d81cb3747f48c9be4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:38:39Z
date_updated: 2023-08-03T12:38:39Z
file_id: '13622'
file_name: Extdata04_BASSOON_xz_3-4.tif
file_size: 53362
relation: main_file
success: 1
- access_level: open_access
checksum: 57fa91bfb1e2937e3449e57096b6fc74
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:38:50Z
date_updated: 2023-08-03T12:38:50Z
file_id: '13623'
file_name: Extdata04_BASSOON_xz_n2v.tif
file_size: 576071410
relation: main_file
success: 1
- access_level: open_access
checksum: ac51a734dcf7d1b94afcd4a471f10626
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:38:46Z
date_updated: 2023-08-03T12:38:46Z
file_id: '13624'
file_name: Extdata04_BASSOON_xz.tif
file_size: 288066640
relation: main_file
success: 1
- access_level: open_access
checksum: 244043f7acba250d560e29123702dcd7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:40:57Z
date_updated: 2023-08-03T12:40:57Z
file_id: '13625'
file_name: Extdata04_HOMER1_xy_1.tif
file_size: 7109763
relation: main_file
success: 1
- access_level: open_access
checksum: eff51ff97539f6491989bfc3d3f88860
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:40:57Z
date_updated: 2023-08-03T12:40:57Z
file_id: '13626'
file_name: Extdata04_HOMER1_xy_2-3.tif
file_size: 72963
relation: main_file
success: 1
- access_level: open_access
checksum: df35046d9bca4e97a5625c5a55218cfb
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:40:57Z
date_updated: 2023-08-03T12:40:57Z
file_id: '13627'
file_name: Extdata04_HOMER1_xz_1-2.tif
file_size: 53375
relation: main_file
success: 1
- access_level: open_access
checksum: 5dc7536f7aaea084dfc329537d8412ce
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:40:57Z
date_updated: 2023-08-03T12:40:57Z
file_id: '13628'
file_name: Extdata04_HOMER1_xz_3-4.tif
file_size: 53359
relation: main_file
success: 1
- access_level: open_access
checksum: 0b407669a26b9d7730a41361ceffda9a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:41:00Z
date_updated: 2023-08-03T12:41:00Z
file_id: '13629'
file_name: Extdata04_HOMER1_xz_n2v.tif
file_size: 204861339
relation: main_file
success: 1
- access_level: open_access
checksum: f95a0da9bea8b605fc2ed310190836b3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:40:59Z
date_updated: 2023-08-03T12:40:59Z
file_id: '13630'
file_name: Extdata04_HOMER1_xz.tif
file_size: 102457527
relation: main_file
success: 1
- access_level: open_access
checksum: cf74307696548e7aa90e59a0935a74a1
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:45:08Z
date_updated: 2023-08-03T12:45:08Z
file_id: '13631'
file_name: Extdata04_SHANK2_xy_1.tif
file_size: 7120361
relation: main_file
success: 1
- access_level: open_access
checksum: 7b3490246df4f5bb68d0df682161820f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:45:08Z
date_updated: 2023-08-03T12:45:08Z
file_id: '13632'
file_name: Extdata04_SHANK2_xy_2-3.tif
file_size: 72973
relation: main_file
success: 1
- access_level: open_access
checksum: c599d6830e61c386219e266f4717fe7c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:45:08Z
date_updated: 2023-08-03T12:45:08Z
file_id: '13633'
file_name: Extdata04_SHANK2_xz_1-2.tif
file_size: 53443
relation: main_file
success: 1
- access_level: open_access
checksum: 5b9912b2a408d224ad669f39dc8d5bc6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:45:08Z
date_updated: 2023-08-03T12:45:08Z
file_id: '13634'
file_name: Extdata04_SHANK2_xz_3-4.tif
file_size: 53362
relation: main_file
success: 1
- access_level: open_access
checksum: 17f2064ceeb99cbb51208c27b1961ed5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:45:30Z
date_updated: 2023-08-03T12:45:30Z
file_id: '13635'
file_name: Extdata04_SHANK2_xz_n2v.tif
file_size: 691291157
relation: main_file
success: 1
- access_level: open_access
checksum: 21f1bb8d2a00c88bdd6febe6285acc2a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:45:26Z
date_updated: 2023-08-03T12:45:26Z
file_id: '13636'
file_name: Extdata04_SHANK2_xz.tif
file_size: 518519275
relation: main_file
success: 1
- access_level: open_access
checksum: 47597ca873f1ea81cd4f7e9bfbb34aa4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:46:25Z
date_updated: 2023-08-03T12:46:25Z
file_id: '13637'
file_name: Extdata04_GEPHYRIN_xy_1.tif
file_size: 752109
relation: main_file
success: 1
- access_level: open_access
checksum: 14ed7ae64eb783e6b30f824f21959d0f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:46:25Z
date_updated: 2023-08-03T12:46:25Z
file_id: '13638'
file_name: Extdata04_GEPHYRIN_xy_2-3.tif
file_size: 72909
relation: main_file
success: 1
- access_level: open_access
checksum: e361e226428d7b23618eed35b1cad080
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:46:25Z
date_updated: 2023-08-03T12:46:25Z
file_id: '13639'
file_name: Extdata04_GEPHYRIN_xz_1-2.tif
file_size: 53375
relation: main_file
success: 1
- access_level: open_access
checksum: abe7cee22f69fc2bf1a3ff9955ccf45a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:46:25Z
date_updated: 2023-08-03T12:46:25Z
file_id: '13640'
file_name: Extdata04_GEPHYRIN_xz_3-4.tif
file_size: 53360
relation: main_file
success: 1
- access_level: open_access
checksum: 59b49b451a63c5ac06fa31a17640c1a2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:46:27Z
date_updated: 2023-08-03T12:46:27Z
file_id: '13641'
file_name: Extdata04_GEPHYRIN_xz_n2v.tif
file_size: 73174939
relation: main_file
success: 1
- access_level: open_access
checksum: 1ee1feea85c8319ebc6c49147502e412
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:46:26Z
date_updated: 2023-08-03T12:46:26Z
file_id: '13642'
file_name: Extdata04_GEPHYRIN_xz.tif
file_size: 36614327
relation: main_file
success: 1
- access_level: open_access
checksum: 64d9d868ef89c5cfc65cb199aff831b4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:52:23Z
date_updated: 2023-08-03T12:52:23Z
file_id: '13643'
file_name: Extdata06_a-b_n2v.tif
file_size: 2195652677
relation: main_file
success: 1
- access_level: open_access
checksum: df41d97987798715b1f66e6e72be169b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:51:41Z
date_updated: 2023-08-03T12:51:41Z
file_id: '13644'
file_name: Extdata06_a-b.tif
file_size: 1097875840
relation: main_file
success: 1
- access_level: open_access
checksum: 95a3eaa3b70e964f6871a5765a53659b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:52:57Z
date_updated: 2023-08-03T12:52:57Z
file_id: '13645'
file_name: Extdata07_01_bottom.tif
file_size: 3564577
relation: main_file
success: 1
- access_level: open_access
checksum: 80b41ad0de73fd61eb67a35262627fac
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:52:57Z
date_updated: 2023-08-03T12:52:57Z
file_id: '13646'
file_name: Extdata07_01_top.tif
file_size: 11958844
relation: main_file
success: 1
- access_level: open_access
checksum: f694a0f11e2f782702cb4c411941873a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:27Z
date_updated: 2023-08-03T12:54:27Z
file_id: '13647'
file_name: Extdata07_2_bottom.tif
file_size: 3564581
relation: main_file
success: 1
- access_level: open_access
checksum: b8b1a1339a25806615c0aa7906a032ff
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:27Z
date_updated: 2023-08-03T12:54:27Z
file_id: '13648'
file_name: Extdata07_2_top.tif
file_size: 11973592
relation: main_file
success: 1
- access_level: open_access
checksum: 8a24eb623d65d809fe8afbd527528a77
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:27Z
date_updated: 2023-08-03T12:54:27Z
file_id: '13649'
file_name: Extdata07_3_bottom.tif
file_size: 1281901
relation: main_file
success: 1
- access_level: open_access
checksum: 816b35def703bc48d55b0293fcd8212f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:27Z
date_updated: 2023-08-03T12:54:27Z
file_id: '13650'
file_name: Extdata07_3_top.tif
file_size: 16569776
relation: main_file
success: 1
- access_level: open_access
checksum: 7f1375ab8cf28cd136e2e44d1fdfd87d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:27Z
date_updated: 2023-08-03T12:54:27Z
file_id: '13651'
file_name: Extdata07_04_bottom.tif
file_size: 3564595
relation: main_file
success: 1
- access_level: open_access
checksum: b1dbda28e2a010968716c0411568f139
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:27Z
date_updated: 2023-08-03T12:54:27Z
file_id: '13652'
file_name: Extdata07_04_top.tif
file_size: 5896404
relation: main_file
success: 1
- access_level: open_access
checksum: d6e96b7c8e6a7084c14eda83a4dd778a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13653'
file_name: Extdata07_5_bottom.tif
file_size: 3564609
relation: main_file
success: 1
- access_level: open_access
checksum: a647f89a3048f71512cc58c9e53ec022
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13654'
file_name: Extdata07_5_top.tif
file_size: 15555618
relation: main_file
success: 1
- access_level: open_access
checksum: 66becb046fe591914df572617d720202
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13655'
file_name: Extdata07_6_bottom.tif
file_size: 3564577
relation: main_file
success: 1
- access_level: open_access
checksum: 5d76b2ad7d7acbb1afa27cf52194b1cb
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13656'
file_name: Extdata07_6_top.tif
file_size: 6038186
relation: main_file
success: 1
- access_level: open_access
checksum: 7f137bdea0f0acb3db75c983ce44ab44
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13657'
file_name: Extdata07_7_bottom.tif
file_size: 3560937
relation: main_file
success: 1
- access_level: open_access
checksum: 479e26106280eb61a2d74e29137a2e43
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13658'
file_name: Extdata07_7_top.tif
file_size: 12031850
relation: main_file
success: 1
- access_level: open_access
checksum: 8426197ad283c1bc83e3193f323d5f5a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13659'
file_name: Extdata07_8_bottom.tif
file_size: 3560937
relation: main_file
success: 1
- access_level: open_access
checksum: b9f75a82b564e1c5c363a495d078f6b7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13660'
file_name: Extdata07_8_top.tif
file_size: 22877176
relation: main_file
success: 1
- access_level: open_access
checksum: 7f1a9f3bb9611362995ae832b2607f4d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13661'
file_name: Extdata07_9_bottom.tif
file_size: 3564605
relation: main_file
success: 1
- access_level: open_access
checksum: 40286bcb876b655d7421534d0215e86b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T12:54:28Z
date_updated: 2023-08-03T12:54:28Z
file_id: '13662'
file_name: Extdata07_9_top.tif
file_size: 2744190
relation: main_file
success: 1
- access_level: open_access
checksum: 4af220986cc94d412c2354aa7e6c8cce
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:00:03Z
date_updated: 2023-08-03T13:00:03Z
file_id: '13663'
file_name: Extdata08_6_left.png
file_size: 7243611
relation: main_file
success: 1
- access_level: open_access
checksum: af9c2299f1005a3ccc39f41082cea642
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:03Z
date_updated: 2023-08-03T13:00:03Z
file_id: '13664'
file_name: Extdata08_6_right.tif
file_size: 5562487
relation: main_file
success: 1
- access_level: open_access
checksum: 63ef28a174215c70e31d2cabf67d90fc
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:04Z
date_updated: 2023-08-03T13:00:04Z
file_id: '13665'
file_name: Extdata08_7_left.tif
file_size: 34745956
relation: main_file
success: 1
- access_level: open_access
checksum: 46de918dfe5f3c23e497ee3daa608dd9
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:03Z
date_updated: 2023-08-03T13:00:03Z
file_id: '13666'
file_name: Extdata08_7_right.tif
file_size: 5562483
relation: main_file
success: 1
- access_level: open_access
checksum: 8243a7985d2902446183adc35519a0c8
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:04Z
date_updated: 2023-08-03T13:00:04Z
file_id: '13667'
file_name: Extdata08_b_1_left.tif
file_size: 31506150
relation: main_file
success: 1
- access_level: open_access
checksum: 857cffa31569efcd5917f9802a106d58
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:04Z
date_updated: 2023-08-03T13:00:04Z
file_id: '13668'
file_name: Extdata08_b_1_right.tif
file_size: 11117705
relation: main_file
success: 1
- access_level: open_access
checksum: e34902de9119d2cd9f1910f610627c5f
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:00:04Z
date_updated: 2023-08-03T13:00:04Z
file_id: '13669'
file_name: Extdata08_b_2_left.png
file_size: 3540493
relation: main_file
success: 1
- access_level: open_access
checksum: 1247d636ac5af22e8950ffd2ff213fea
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:05Z
date_updated: 2023-08-03T13:00:05Z
file_id: '13670'
file_name: Extdata08_b_2_right.tif
file_size: 5562553
relation: main_file
success: 1
- access_level: open_access
checksum: f47c2d3f6824e08853ae2631f6ee7c5f
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:00:05Z
date_updated: 2023-08-03T13:00:05Z
file_id: '13671'
file_name: Extdata08_b_3_left.png
file_size: 3541547
relation: main_file
success: 1
- access_level: open_access
checksum: 1247d636ac5af22e8950ffd2ff213fea
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:05Z
date_updated: 2023-08-03T13:00:05Z
file_id: '13672'
file_name: Extdata08_b_3_right.tif
file_size: 5562553
relation: main_file
success: 1
- access_level: open_access
checksum: e90a95ec902a683678acd70336852fd9
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:05Z
date_updated: 2023-08-03T13:00:05Z
file_id: '13673'
file_name: Extdata08_b_4_left.tif
file_size: 25819844
relation: main_file
success: 1
- access_level: open_access
checksum: 94cd44cd1c8c7a87ffd5861bf88561a1
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:05Z
date_updated: 2023-08-03T13:00:05Z
file_id: '13674'
file_name: Extdata08_b_4_right.tif
file_size: 5561131
relation: main_file
success: 1
- access_level: open_access
checksum: fd4ca56dc5c48ad4546df22daef04efc
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:06Z
date_updated: 2023-08-03T13:00:06Z
file_id: '13675'
file_name: Extdata08_b_5_left.tif
file_size: 38786287
relation: main_file
success: 1
- access_level: open_access
checksum: 52c04890160c4e0f23d3fe2d3ed0c8e7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:00:06Z
date_updated: 2023-08-03T13:00:06Z
file_id: '13676'
file_name: Extdata08_b_5_right.tif
file_size: 5562487
relation: main_file
success: 1
- access_level: open_access
checksum: 47ee6f4b083130d5bb720bcf8a832443
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:52Z
date_updated: 2023-08-03T13:04:52Z
file_id: '13677'
file_name: Extdata08_a_1-1.png
file_size: 2133527
relation: main_file
success: 1
- access_level: open_access
checksum: 5ca2279c372b3b7dbce3ea5658a68399
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:52Z
date_updated: 2023-08-03T13:04:52Z
file_id: '13678'
file_name: Extdata08_a_1-2.png
file_size: 1782607
relation: main_file
success: 1
- access_level: open_access
checksum: 34b7781e3e4abf9f30a0c85db156b6d5
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:52Z
date_updated: 2023-08-03T13:04:52Z
file_id: '13679'
file_name: Extdata08_a_2.png
file_size: 5117469
relation: main_file
success: 1
- access_level: open_access
checksum: 25717007393682098d2208bd0676a0f7
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:52Z
date_updated: 2023-08-03T13:04:52Z
file_id: '13680'
file_name: Extdata08_a_3.png
file_size: 6911658
relation: main_file
success: 1
- access_level: open_access
checksum: b4b003809acec33c71628066744c7ea9
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:53Z
date_updated: 2023-08-03T13:04:53Z
file_id: '13681'
file_name: Extdata08_a_4.png
file_size: 8579427
relation: main_file
success: 1
- access_level: open_access
checksum: 4410976cf867ecacf8f197dbd28cc5a0
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:53Z
date_updated: 2023-08-03T13:04:53Z
file_id: '13682'
file_name: Extdata08_a_5.png
file_size: 9675065
relation: main_file
success: 1
- access_level: open_access
checksum: a235dd204f28d3323883e044b031b984
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:53Z
date_updated: 2023-08-03T13:04:53Z
file_id: '13683'
file_name: Extdata08_a_6.png
file_size: 9769588
relation: main_file
success: 1
- access_level: open_access
checksum: 0e2b768e4eb7200cf6fe28ba511a5ef6
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:53Z
date_updated: 2023-08-03T13:04:53Z
file_id: '13684'
file_name: Extdata08_a_7.png
file_size: 9114791
relation: main_file
success: 1
- access_level: open_access
checksum: df4a01c62233ee8ed601c4b90d7780d0
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:04:57Z
date_updated: 2023-08-03T13:04:57Z
file_id: '13685'
file_name: Extdata08_a_8.png
file_size: 124540688
relation: main_file
success: 1
- access_level: open_access
checksum: 1f407c7915e2717a56fec258708e7b7a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:11:30Z
date_updated: 2023-08-03T13:11:30Z
file_id: '13686'
file_name: Exdata09_c_n2v.tif
file_size: 204861336
relation: main_file
success: 1
- access_level: open_access
checksum: 9089dc7c9914edf9750eebd65819708d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:11:26Z
date_updated: 2023-08-03T13:11:26Z
file_id: '13687'
file_name: Extdata09_a_zoom.tif
file_size: 252149
relation: main_file
success: 1
- access_level: open_access
checksum: 62d295a62cb8dd36c268b28cf0251322
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:11:26Z
date_updated: 2023-08-03T13:11:26Z
file_id: '13688'
file_name: Extdata09_a.tif
file_size: 11117705
relation: main_file
success: 1
- access_level: open_access
checksum: e874d8ee287f924c1076134b5b06bdb2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:11:31Z
date_updated: 2023-08-03T13:11:31Z
file_id: '13689'
file_name: Extdata09_b_n2v.tif
file_size: 256074660
relation: main_file
success: 1
- access_level: open_access
checksum: 488068fff7b42bcf5728739e2a06d742
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:12:53Z
date_updated: 2023-08-03T13:12:53Z
file_id: '13690'
file_name: Extdata10_n2v_CLAHE.tif
file_size: 127914854
relation: main_file
success: 1
- access_level: open_access
checksum: 35351f5af21ce854d41577813a7bdb57
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13691'
file_name: Supplfig01_a_1.png
file_size: 430878
relation: main_file
success: 1
- access_level: open_access
checksum: 36204e9e604206366ffc6f61ec91915b
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13692'
file_name: Supplfig01_a_2.png
file_size: 438843
relation: main_file
success: 1
- access_level: open_access
checksum: 92ccc934c4603b29f4f7a96573e49c83
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13693'
file_name: Supplfig01_a_3.png
file_size: 426713
relation: main_file
success: 1
- access_level: open_access
checksum: e71faa54934bee8ac3e66ce692f542ab
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13694'
file_name: Supplfig01_a_4.tif
file_size: 723221
relation: main_file
success: 1
- access_level: open_access
checksum: 95dc33563f48b650e5ac020bdfd10c48
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13695'
file_name: Supplfig01_a_5.tif
file_size: 723235
relation: main_file
success: 1
- access_level: open_access
checksum: c62df0a9faf1c47af121d77eb1582edd
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13696'
file_name: Supplfig01_b_1.tif
file_size: 1442129
relation: main_file
success: 1
- access_level: open_access
checksum: 8ae157c5a4a543da1193cb8ca12b1919
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13697'
file_name: Supplfig01_b_2.tif
file_size: 725407
relation: main_file
success: 1
- access_level: open_access
checksum: 388370d954ce842781c0d62edfb448a7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13698'
file_name: Supplfig01_c_1.tif
file_size: 721641
relation: main_file
success: 1
- access_level: open_access
checksum: 6cae58ba3c98bc8253e1c769e93657a7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13699'
file_name: Supplfig01_c_2.tif
file_size: 6003079
relation: main_file
success: 1
- access_level: open_access
checksum: 85cf013232c72895aefc07f5411a765a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13700'
file_name: Supplfig01_c_3.tif
file_size: 2003311
relation: main_file
success: 1
- access_level: open_access
checksum: dfb33b91066e3f34d3803f59a4105aba
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13701'
file_name: Supplfig01_c_4.tif
file_size: 723271
relation: main_file
success: 1
- access_level: open_access
checksum: 8b899826fe48d7e7536b0b02a2645e87
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13702'
file_name: Supplfig01_d_1.tif
file_size: 721901
relation: main_file
success: 1
- access_level: open_access
checksum: 67529fa6e0f12c272275e823f6045f6d
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13703'
file_name: Supplfig01_d_2.tif
file_size: 721901
relation: main_file
success: 1
- access_level: open_access
checksum: 111a9231f63c775340d3356109715cb0
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13704'
file_name: Supplfig01_e_1.tif
file_size: 723223
relation: main_file
success: 1
- access_level: open_access
checksum: 7685bf02408dcb095a00854ff22763ed
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:21:35Z
date_updated: 2023-08-03T13:21:35Z
file_id: '13705'
file_name: Supplfig01_e_2.tif
file_size: 723223
relation: main_file
success: 1
- access_level: open_access
checksum: 455f5cb9aa8a87b91586a27aca122610
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:00Z
date_updated: 2023-08-03T13:26:00Z
file_id: '13706'
file_name: Supplfig02_b_01.tif
file_size: 34821298
relation: main_file
success: 1
- access_level: open_access
checksum: 311545b39aaa2c72755fd8ae190803a5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:00Z
date_updated: 2023-08-03T13:26:00Z
file_id: '13707'
file_name: Supplfig02_b_02.tif
file_size: 32131123
relation: main_file
success: 1
- access_level: open_access
checksum: 682deb61f57d9ca54716160ddd52a6cf
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:01Z
date_updated: 2023-08-03T13:26:01Z
file_id: '13708'
file_name: Supplfig02_b_03.tif
file_size: 36872674
relation: main_file
success: 1
- access_level: open_access
checksum: 4f9579c91b2a3f36ff6e66b592907973
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:01Z
date_updated: 2023-08-03T13:26:01Z
file_id: '13709'
file_name: Supplfig02_b_04.tif
file_size: 39964115
relation: main_file
success: 1
- access_level: open_access
checksum: 7ae7053673b53dbed59ffb92618f969a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:02Z
date_updated: 2023-08-03T13:26:02Z
file_id: '13710'
file_name: Supplfig02_b_05.tif
file_size: 43053091
relation: main_file
success: 1
- access_level: open_access
checksum: 827b26d3d2b6ddc9bced9d6113023ced
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:02Z
date_updated: 2023-08-03T13:26:02Z
file_id: '13711'
file_name: Supplfig02_b_06.tif
file_size: 46998147
relation: main_file
success: 1
- access_level: open_access
checksum: bc2e7e8badb42f8e1facc8b7bc96fdda
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:03Z
date_updated: 2023-08-03T13:26:03Z
file_id: '13712'
file_name: Supplfig02_b_07.tif
file_size: 45179219
relation: main_file
success: 1
- access_level: open_access
checksum: c2b78aa0f433928afa10a743c5fb73b8
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:03Z
date_updated: 2023-08-03T13:26:03Z
file_id: '13713'
file_name: Supplfig02_b_08.tif
file_size: 46978802
relation: main_file
success: 1
- access_level: open_access
checksum: 9cd1ab61cced2c0981e813aeae930855
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:04Z
date_updated: 2023-08-03T13:26:04Z
file_id: '13714'
file_name: Supplfig02_b_09.tif
file_size: 48840915
relation: main_file
success: 1
- access_level: open_access
checksum: 3086126338aee6ec4ebc1d3350551197
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:04Z
date_updated: 2023-08-03T13:26:04Z
file_id: '13715'
file_name: Supplfig02_b_10.tif
file_size: 45907059
relation: main_file
success: 1
- access_level: open_access
checksum: 69f52c2b3bb5b5f9fef057860b3386fa
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:05Z
date_updated: 2023-08-03T13:26:05Z
file_id: '13716'
file_name: Supplfig02_b_11.tif
file_size: 32231538
relation: main_file
success: 1
- access_level: open_access
checksum: defdbeab1e672456bfeafdd1983e779e
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:26:05Z
date_updated: 2023-08-03T13:26:05Z
file_id: '13717'
file_name: Supplfig02_b_12.tif
file_size: 35264963
relation: main_file
success: 1
- access_level: open_access
checksum: 02c566f781b9ad44f04ce0088a1fa27a
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:28:40Z
date_updated: 2023-08-03T13:28:40Z
file_id: '13718'
file_name: Supplfig03_a_std_xy.png
file_size: 63326
relation: main_file
success: 1
- access_level: open_access
checksum: c6c3630ee9a6ed5d207cb68e330da566
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:28:40Z
date_updated: 2023-08-03T13:28:40Z
file_id: '13719'
file_name: Supplfig03_a_std_xz.png
file_size: 50211
relation: main_file
success: 1
- access_level: open_access
checksum: 0dcd4d19e83a7ff259d6aa04d746cd90
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:28:41Z
date_updated: 2023-08-03T13:28:41Z
file_id: '13720'
file_name: Supplfig03_b_std_xy.png
file_size: 52629
relation: main_file
success: 1
- access_level: open_access
checksum: 4785de4a6dcb23b25a06b0da29df5bb5
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:28:41Z
date_updated: 2023-08-03T13:28:41Z
file_id: '13721'
file_name: Supplfig03_b_std_xz.png
file_size: 72245
relation: main_file
success: 1
- access_level: open_access
checksum: 19d0f198bd8a25073e45e7950d7a78c2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:28:45Z
date_updated: 2023-08-03T13:28:45Z
file_id: '13722'
file_name: Supplfig03_model1.tif
file_size: 98570368
relation: main_file
success: 1
- access_level: open_access
checksum: 51ff687df4a0867f39b69c2c7a4ee3ca
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:28:45Z
date_updated: 2023-08-03T13:28:45Z
file_id: '13723'
file_name: Supplfig03_model2.tif
file_size: 98570367
relation: main_file
success: 1
- access_level: open_access
checksum: ec9d9a041ca85fe632c612baf981fcc5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:28:49Z
date_updated: 2023-08-03T13:28:49Z
file_id: '13724'
file_name: Supplfig03_model3.tif
file_size: 98570365
relation: main_file
success: 1
- access_level: open_access
checksum: a988b15a9529094f1b5519a72871e98e
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:28:49Z
date_updated: 2023-08-03T13:28:49Z
file_id: '13725'
file_name: Supplfig03_model4.tif
file_size: 98570365
relation: main_file
success: 1
- access_level: open_access
checksum: 4a4fe88fcfd87fcfe118a5a73d81d6b0
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:28:52Z
date_updated: 2023-08-03T13:28:52Z
file_id: '13726'
file_name: Supplfig03_model5.tif
file_size: 98570369
relation: main_file
success: 1
- access_level: open_access
checksum: ce9b774ff5163ebfa4e3fb162f4cfffe
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:27Z
date_updated: 2023-08-03T13:34:27Z
file_id: '13727'
file_name: Supplfig04_a_n2v.tif
file_size: 1036927887
relation: main_file
success: 1
- access_level: open_access
checksum: 21f1bb8d2a00c88bdd6febe6285acc2a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:13Z
date_updated: 2023-08-03T13:34:13Z
file_id: '13728'
file_name: Supplfig04_a.tif
file_size: 518519275
relation: main_file
success: 1
- access_level: open_access
checksum: 503820214ab994c01b18a241f3b62434
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:22Z
date_updated: 2023-08-03T13:34:22Z
file_id: '13729'
file_name: Supplfig04_b.tif
file_size: 158440069
relation: main_file
success: 1
- access_level: open_access
checksum: e0469102a87332b46904b4ba35b8fb2f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:37Z
date_updated: 2023-08-03T13:34:37Z
file_id: '13730'
file_name: Supplfig04_c_n2v.tif
file_size: 309407894
relation: main_file
success: 1
- access_level: open_access
checksum: c30a0d18c43045a8fbc5501a37061bd2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:38Z
date_updated: 2023-08-03T13:34:38Z
file_id: '13731'
file_name: Supplfig04_c.tif
file_size: 154728887
relation: main_file
success: 1
- access_level: open_access
checksum: 69c706710d642b30cda6951494702139
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:43Z
date_updated: 2023-08-03T13:34:43Z
file_id: '13732'
file_name: Supplfig04_d_n2v.tif
file_size: 106696749
relation: main_file
success: 1
- access_level: open_access
checksum: 7dbd2e881ebf049352913188fa10224a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:41Z
date_updated: 2023-08-03T13:34:41Z
file_id: '13733'
file_name: Supplfig04_d.tif
file_size: 53367343
relation: main_file
success: 1
- access_level: open_access
checksum: fd0d1ec674dabbb499fab383b7eb4d58
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:46Z
date_updated: 2023-08-03T13:34:46Z
file_id: '13734'
file_name: Supplfig04_e_n2v.tiff
file_size: 127917734
relation: main_file
success: 1
- access_level: open_access
checksum: 86de309d9cd434afbe371da283d8adb6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:34:46Z
date_updated: 2023-08-03T13:34:46Z
file_id: '13735'
file_name: Supplfig04_e.tif
file_size: 63974204
relation: main_file
success: 1
- access_level: open_access
checksum: ada99b2b5900cb198d1de3cc9e37ebd1
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13736'
file_name: Supplfig05_a_xy_1.png
file_size: 8403
relation: main_file
success: 1
- access_level: open_access
checksum: f2e382925a972b98560614016ae3bc55
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13737'
file_name: Supplfig05_a_xy_2.png
file_size: 10087
relation: main_file
success: 1
- access_level: open_access
checksum: ef22b640f33d677add1a7b5153f95420
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13738'
file_name: Supplfig05_a_xy_3.png
file_size: 24561
relation: main_file
success: 1
- access_level: open_access
checksum: b854cc4a5224b8a6f5d59c74f5740ccd
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13739'
file_name: Supplfig05_a_xy_4.png
file_size: 8353
relation: main_file
success: 1
- access_level: open_access
checksum: 446b0362c5ea6e2a5f0e1f8359422358
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13740'
file_name: Supplfig05_a_xy_5.png
file_size: 8337
relation: main_file
success: 1
- access_level: open_access
checksum: 5585f7b62fa09ed5a63090b679383601
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13741'
file_name: Supplfig05_a_xz_1.png
file_size: 7399
relation: main_file
success: 1
- access_level: open_access
checksum: 190d88bcacbd11d41f4a0e2bbd140862
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13742'
file_name: Supplfig05_a_xz_2.png
file_size: 10887
relation: main_file
success: 1
- access_level: open_access
checksum: 0c89010651862f21032a303e159b7a1c
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13743'
file_name: Supplfig05_a_xz_3.png
file_size: 21654
relation: main_file
success: 1
- access_level: open_access
checksum: 94e61e553aa2280721acce7d407ff24a
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13744'
file_name: Supplfig05_a_xz_4.png
file_size: 7248
relation: main_file
success: 1
- access_level: open_access
checksum: ef9157274686ff5d7056f5a519d413dd
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13745'
file_name: Supplfig05_a_xz_5.png
file_size: 7214
relation: main_file
success: 1
- access_level: open_access
checksum: 4b389473cbf769e6e34670dae2224af1
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13746'
file_name: Supplfig05_b_xy_1.png
file_size: 8544
relation: main_file
success: 1
- access_level: open_access
checksum: b05aa1e201758a5d55e35d719452fafc
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13747'
file_name: Supplfig05_b_xy_2.png
file_size: 11135
relation: main_file
success: 1
- access_level: open_access
checksum: 890f3516930251a367066c049141d6bb
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13748'
file_name: Supplfig05_b_xy_3.png
file_size: 26762
relation: main_file
success: 1
- access_level: open_access
checksum: 36345c1d582758ff463072fd04578c0c
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13749'
file_name: Supplfig05_b_xy_4.png
file_size: 8438
relation: main_file
success: 1
- access_level: open_access
checksum: c9499ad8914c405a07fc4469b19e8987
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13750'
file_name: Supplfig05_b_xy_5.png
file_size: 8434
relation: main_file
success: 1
- access_level: open_access
checksum: 7e7a7c900ce1fc3187ab648f207f9425
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13751'
file_name: Supplfig05_b_xz_1.png
file_size: 8269
relation: main_file
success: 1
- access_level: open_access
checksum: b645d1e2422ef3f05344ccd3f955468d
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13752'
file_name: Supplfig05_b_xz_2.png
file_size: 12762
relation: main_file
success: 1
- access_level: open_access
checksum: ef0b83b49cf47ca7d8ffe3bdc609fe38
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13753'
file_name: Supplfig05_b_xz_3.png
file_size: 24819
relation: main_file
success: 1
- access_level: open_access
checksum: 68719d4d464a2ffc198cb6ad070c4579
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:37Z
date_updated: 2023-08-03T13:35:37Z
file_id: '13754'
file_name: Supplfig05_b_xz_4.png
file_size: 8126
relation: main_file
success: 1
- access_level: open_access
checksum: 18370f47177ef37a477c6fd7bda3fea0
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13755'
file_name: Supplfig05_b_xz_5.png
file_size: 8114
relation: main_file
success: 1
- access_level: open_access
checksum: 013d4bd9704ace490810b9ef21b12454
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13756'
file_name: Supplfig05_c_xy_1.png
file_size: 8273
relation: main_file
success: 1
- access_level: open_access
checksum: bb431f827386e79c54452d6284f501b9
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13757'
file_name: Supplfig05_c_xy_2.png
file_size: 12639
relation: main_file
success: 1
- access_level: open_access
checksum: 4cd54f58c5afff88832a508655f913bb
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13758'
file_name: Supplfig05_c_xy_3.png
file_size: 25288
relation: main_file
success: 1
- access_level: open_access
checksum: 07f86f98f6a65eac8608cec8c567309e
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13759'
file_name: Supplfig05_c_xz_1.png
file_size: 6786
relation: main_file
success: 1
- access_level: open_access
checksum: 492f699b71761214272b17432e3a54fa
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13760'
file_name: Supplfig05_c_xz_2.png
file_size: 9781
relation: main_file
success: 1
- access_level: open_access
checksum: af617da5638db849bea6ff51a08227c6
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13761'
file_name: Supplfig05_c_xz_3.png
file_size: 20728
relation: main_file
success: 1
- access_level: open_access
checksum: 5e5d5694af4a22297046d697a01fa4d6
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13762'
file_name: Supplfig05_d_xy_1.png
file_size: 8428
relation: main_file
success: 1
- access_level: open_access
checksum: 38bf7b75f3dedd0a3722faae05aa0233
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13763'
file_name: Supplfig05_d_xy_2.png
file_size: 10813
relation: main_file
success: 1
- access_level: open_access
checksum: e4ea966553f158ec2cfbdc696780390e
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13764'
file_name: Supplfig05_d_xy_3.png
file_size: 26552
relation: main_file
success: 1
- access_level: open_access
checksum: 356f424d9f5f608e9aea962bb63672f1
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13765'
file_name: Supplfig05_d_xz_1.png
file_size: 7876
relation: main_file
success: 1
- access_level: open_access
checksum: 05068476beee0f394e28b98209686394
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13766'
file_name: Supplfig05_d_xz_2.png
file_size: 11634
relation: main_file
success: 1
- access_level: open_access
checksum: 78b3a0d93df22383a384a2f3acc80401
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13767'
file_name: Supplfig05_d_xz_3.png
file_size: 25006
relation: main_file
success: 1
- access_level: open_access
checksum: f5ee6a817f11a42c9db82ad6325f58b9
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13768'
file_name: Supplfig05_e_xy_1.png
file_size: 7895
relation: main_file
success: 1
- access_level: open_access
checksum: 019ca89e892d6e19589609bc99eab331
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13769'
file_name: Supplfig05_e_xy_2.png
file_size: 6180
relation: main_file
success: 1
- access_level: open_access
checksum: 0e1a5cbbd70dc245edaecaca70d974cb
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13770'
file_name: Supplfig05_e_xy_3.png
file_size: 18326
relation: main_file
success: 1
- access_level: open_access
checksum: 4d4d64a5bb7b096aaf8130ece4512bc2
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13771'
file_name: Supplfig05_e_xz_1.png
file_size: 6295
relation: main_file
success: 1
- access_level: open_access
checksum: 607302aec5ec2a14a271dbffd3465261
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13772'
file_name: Supplfig05_e_xz_2.png
file_size: 4335
relation: main_file
success: 1
- access_level: open_access
checksum: a673e17ead1fd2e776b9a5f560a289ab
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T13:35:38Z
date_updated: 2023-08-03T13:35:38Z
file_id: '13773'
file_name: Supplfig05_e_xz_3.png
file_size: 23243
relation: main_file
success: 1
- access_level: open_access
checksum: 4349e511fc86a8bddb790a7be7175c75
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:13Z
date_updated: 2023-08-03T13:46:13Z
file_id: '13774'
file_name: Supplfig06_a_1.tif
file_size: 4002153
relation: main_file
success: 1
- access_level: open_access
checksum: cd12977e4c1a472d80193be01f69a895
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:13Z
date_updated: 2023-08-03T13:46:13Z
file_id: '13775'
file_name: Supplfig06_a_2.tif
file_size: 2252137
relation: main_file
success: 1
- access_level: open_access
checksum: 575e32b8c25ce658e20f0c86a5f1b9b7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:13Z
date_updated: 2023-08-03T13:46:13Z
file_id: '13776'
file_name: Supplfig06_a_3.tif
file_size: 2252137
relation: main_file
success: 1
- access_level: open_access
checksum: b06f775e0210e7a16cb4b58aed32118c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:13Z
date_updated: 2023-08-03T13:46:13Z
file_id: '13777'
file_name: Supplfig06_a_i.tif
file_size: 78329
relation: main_file
success: 1
- access_level: open_access
checksum: 56854c1a05c721c36877fe7c7454b7d7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:13Z
date_updated: 2023-08-03T13:46:13Z
file_id: '13778'
file_name: Supplfig06_a_ii.tif
file_size: 78329
relation: main_file
success: 1
- access_level: open_access
checksum: 9aff42ea5138931fedb5a00643ae7a22
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:13Z
date_updated: 2023-08-03T13:46:13Z
file_id: '13779'
file_name: Supplfig06_a_iii.tif
file_size: 78329
relation: main_file
success: 1
- access_level: open_access
checksum: 9474b7d00d4dee46659afedef75dc095
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:13Z
date_updated: 2023-08-03T13:46:13Z
file_id: '13780'
file_name: Supplfig06_d_1.tif
file_size: 501149
relation: main_file
success: 1
- access_level: open_access
checksum: 53df41dd968b04b4657cd2b91870d636
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:13Z
date_updated: 2023-08-03T13:46:13Z
file_id: '13781'
file_name: Supplfig06_d_2.tif
file_size: 500153
relation: main_file
success: 1
- access_level: open_access
checksum: 1a39b8310598dd25d97f848b682b8de0
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13782'
file_name: Supplfig06_d_3.tif
file_size: 500153
relation: main_file
success: 1
- access_level: open_access
checksum: 6d9b496be6aecedbb2cb4cbf68f02872
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13783'
file_name: Supplfig06_d_i.tif
file_size: 78329
relation: main_file
success: 1
- access_level: open_access
checksum: bc034b1636c2db8b9d9e7bd131b9780a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13784'
file_name: Supplfig06_d_ii.tif
file_size: 78329
relation: main_file
success: 1
- access_level: open_access
checksum: 54f6e55e30a2aeea6c82eb6dbd376240
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13785'
file_name: Supplfig06_d_iii.tif
file_size: 78329
relation: main_file
success: 1
- access_level: open_access
checksum: 446da3cc16897277890f23f966c2bf52
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13786'
file_name: Supplfig06_g_1.tif
file_size: 960011
relation: main_file
success: 1
- access_level: open_access
checksum: 71192d0ec592a33195f2386a5f95aa86
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13787'
file_name: Supplfig06_g_2.tif
file_size: 960011
relation: main_file
success: 1
- access_level: open_access
checksum: 246782dbe8ff525aea360efc72e65f07
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13788'
file_name: Supplfig06_g_3.tif
file_size: 960041
relation: main_file
success: 1
- access_level: open_access
checksum: d49b12fec5508aa8d72587757cccc0a4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13789'
file_name: Supplfig06_g_4.tif
file_size: 960041
relation: main_file
success: 1
- access_level: open_access
checksum: 27b11b1d4fc784a49ffd7660624d00b6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:46:14Z
date_updated: 2023-08-03T13:46:14Z
file_id: '13790'
file_name: Supplfig06_g_5.tif
file_size: 963241
relation: main_file
success: 1
- access_level: open_access
checksum: 9ce944049c1b88fadbf43609385f9e2f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:38Z
date_updated: 2023-08-03T13:51:38Z
file_id: '13791'
file_name: Suppl08_a_1.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 06265515f06688843a415362f7b2c485
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:38Z
date_updated: 2023-08-03T13:51:38Z
file_id: '13792'
file_name: Suppl08_a_2.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 50f0969c6c2c1209ff776bec4861030a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:38Z
date_updated: 2023-08-03T13:51:38Z
file_id: '13793'
file_name: Suppl08_a_3.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: b90965d20133fea73c99050c32eb7695
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:38Z
date_updated: 2023-08-03T13:51:38Z
file_id: '13794'
file_name: Suppl08_a_4.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: 568a1e0efaa62527b51e66a7aabfd05c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:40Z
date_updated: 2023-08-03T13:51:40Z
file_id: '13795'
file_name: Suppl08_a_coCATS_N2V.tif
file_size: 19287339
relation: main_file
success: 1
- access_level: open_access
checksum: 06265515f06688843a415362f7b2c485
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:40Z
date_updated: 2023-08-03T13:51:40Z
file_id: '13796'
file_name: Suppl08_c_1_4_predictedBASSOON.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 568a1e0efaa62527b51e66a7aabfd05c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:43Z
date_updated: 2023-08-03T13:51:43Z
file_id: '13797'
file_name: Suppl08_c_1_coCATS.tif
file_size: 19287339
relation: main_file
success: 1
- access_level: open_access
checksum: feae08c38b1d9c540b697977cd7f2666
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T15:36:47Z
date_updated: 2023-08-03T15:36:47Z
file_id: '13798'
file_name: Suppl08_c_2_coCATS.tif
file_size: 19287340
relation: main_file
success: 1
- access_level: open_access
checksum: af2c1199fdcaecfec76189dae86cc12e
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:44Z
date_updated: 2023-08-03T13:51:44Z
file_id: '13799'
file_name: Suppl08_c_2-3_predictedBASSOON.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 1f92db47605959d0db01f612f7c9c034
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T13:51:43Z
date_updated: 2023-08-03T13:51:43Z
file_id: '13800'
file_name: Suppl08_c_3-6_roi.roi
file_size: 156
relation: main_file
success: 1
- access_level: open_access
checksum: 4fc4f8803adcfacd53a41b91f4699dc5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:45Z
date_updated: 2023-08-03T13:51:45Z
file_id: '13801'
file_name: Suppl08_e_1_3.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 459551aae114daa4f5ca5d06fcd6b203
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:45Z
date_updated: 2023-08-03T13:51:45Z
file_id: '13802'
file_name: Suppl08_e_1-2.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 032cbace7ec436f7b62478c0ffd35e5e
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T13:51:45Z
date_updated: 2023-08-03T13:51:45Z
file_id: '13803'
file_name: Suppl08_e_2-5_roi.roi
file_size: 152
relation: main_file
success: 1
- access_level: open_access
checksum: 7379168be281ef618b8cecd8efd31ed5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:46Z
date_updated: 2023-08-03T13:51:46Z
file_id: '13804'
file_name: Suppl08_e_4-5_coCATS.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 5c4c092f608f4c10bb422c9e08b5955b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:46Z
date_updated: 2023-08-03T13:51:46Z
file_id: '13805'
file_name: Suppl08_e_4.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: 903e31be124f6e4ec1c2e7ab7db80e6b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:46Z
date_updated: 2023-08-03T13:51:46Z
file_id: '13806'
file_name: Suppl08_e_5.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: 173d956392d67b0a7e544629b51881e4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:48Z
date_updated: 2023-08-03T13:51:48Z
file_id: '13807'
file_name: Suppl08_e_6_8.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 2a4cea867a253a6af7e9b0d2e100de14
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:48Z
date_updated: 2023-08-03T13:51:48Z
file_id: '13808'
file_name: Suppl08_e_6-7.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 6b40f99fddfa26f0a9713000769741b7
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T13:51:48Z
date_updated: 2023-08-03T13:51:48Z
file_id: '13809'
file_name: Suppl08_e_7-10_roi.roi
file_size: 174
relation: main_file
success: 1
- access_level: open_access
checksum: 82f7013959df99c27366886de9b38ba2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:49Z
date_updated: 2023-08-03T13:51:49Z
file_id: '13810'
file_name: Suppl08_e_9-10_coCATS.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 50f0969c6c2c1209ff776bec4861030a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:48Z
date_updated: 2023-08-03T13:51:48Z
file_id: '13811'
file_name: Suppl08_e_9.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: 569f599d7f2be49d4dcf7cb385f428c4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:49Z
date_updated: 2023-08-03T13:51:49Z
file_id: '13812'
file_name: Suppl08_e_10.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: 50f0969c6c2c1209ff776bec4861030a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:49Z
date_updated: 2023-08-03T13:51:49Z
file_id: '13813'
file_name: Suppl08_g_1.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: 62797fc860176197142a47e831eaf1f6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:49Z
date_updated: 2023-08-03T13:51:49Z
file_id: '13814'
file_name: Suppl08_g_2.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: b90965d20133fea73c99050c32eb7695
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:49Z
date_updated: 2023-08-03T13:51:49Z
file_id: '13815'
file_name: Suppl08_g_3.tif
file_size: 617552
relation: main_file
success: 1
- access_level: open_access
checksum: a96dc9f38c6a1d3c959771a649a42748
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T13:51:49Z
date_updated: 2023-08-03T13:51:49Z
file_id: '13816'
file_name: Suppl08_i_add_roi.roi
file_size: 160
relation: main_file
success: 1
- access_level: open_access
checksum: f2135207ebbc4bdc014763ba852a5cf0
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T13:51:50Z
date_updated: 2023-08-03T13:51:50Z
file_id: '13817'
file_name: Suppl08_i_shape_roi.roi
file_size: 160
relation: main_file
success: 1
- access_level: open_access
checksum: f6f31fe2d87cf7208387f98ce1e37b04
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T13:51:50Z
date_updated: 2023-08-03T13:51:50Z
file_id: '13818'
file_name: Suppl08_i_split_roi.roi
file_size: 158
relation: main_file
success: 1
- access_level: open_access
checksum: 71590db0ad391e0c5baf03024981b1d9
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:51Z
date_updated: 2023-08-03T13:51:51Z
file_id: '13819'
file_name: Suppl08_i_1.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 9ce944049c1b88fadbf43609385f9e2f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:51Z
date_updated: 2023-08-03T13:51:51Z
file_id: '13820'
file_name: Suppl08_i_2.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 06265515f06688843a415362f7b2c485
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:52Z
date_updated: 2023-08-03T13:51:52Z
file_id: '13821'
file_name: Suppl08_i_3.tiff
file_size: 19286002
relation: main_file
success: 1
- access_level: open_access
checksum: 16c628c160fb81e40df0ad1eb134e92b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:52Z
date_updated: 2023-08-03T13:51:52Z
file_id: '13822'
file_name: Suppl08_i_4.tif
file_size: 19284766
relation: main_file
success: 1
- access_level: open_access
checksum: b06e62c3a9834a40002d7aad3eaacc3f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:53Z
date_updated: 2023-08-03T13:51:53Z
file_id: '13823'
file_name: Suppl08_i_5.tif
file_size: 9649818
relation: main_file
success: 1
- access_level: open_access
checksum: 41ef98c7f01755b43cf6e77fff287732
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:51:53Z
date_updated: 2023-08-03T13:51:53Z
file_id: '13824'
file_name: Suppl08_i_6.tif
file_size: 19284766
relation: main_file
success: 1
- access_level: open_access
checksum: feae08c38b1d9c540b697977cd7f2666
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:53:29Z
date_updated: 2023-08-03T13:53:29Z
file_id: '13825'
file_name: Suppl08_c_2_coCATS.tif
file_size: 19287340
relation: main_file
success: 1
- access_level: open_access
checksum: c01509a1c657fbbbfdbbd484c298b6e3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:58:08Z
date_updated: 2023-08-03T13:58:08Z
file_id: '13826'
file_name: Supplfig09_b_1_n2v.tiff
file_size: 179788642
relation: main_file
success: 1
- access_level: open_access
checksum: 64a7f270274ff3480b18d690087016e2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:58:20Z
date_updated: 2023-08-03T13:58:20Z
file_id: '13827'
file_name: Supplfig09_b_2_n2v.tif
file_size: 742420240
relation: main_file
success: 1
- access_level: open_access
checksum: b34a6beaaf13698f421df961e009efeb
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:58:20Z
date_updated: 2023-08-03T13:58:20Z
file_id: '13828'
file_name: Supplfig09_b_3_n2v.tif
file_size: 478900363
relation: main_file
success: 1
- access_level: open_access
checksum: ec04501f234b5e4fd91f9eac0e585395
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:58:25Z
date_updated: 2023-08-03T13:58:25Z
file_id: '13829'
file_name: Supplfig09_b_4_n2v.tif
file_size: 191873159
relation: main_file
success: 1
- access_level: open_access
checksum: 3a1b313298da35c97550abf0d245b4a7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:59:27Z
date_updated: 2023-08-03T13:59:27Z
file_id: '13830'
file_name: Supplfig11_i.tif
file_size: 55286
relation: main_file
success: 1
- access_level: open_access
checksum: 9cf00c0252f0a2efe1994c83c224389a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:59:27Z
date_updated: 2023-08-03T13:59:27Z
file_id: '13831'
file_name: Supplfig11_ii.tif
file_size: 55286
relation: main_file
success: 1
- access_level: open_access
checksum: 9a6e83acdf6d70bb9a6e76fa7d41a372
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:59:27Z
date_updated: 2023-08-03T13:59:27Z
file_id: '13832'
file_name: Supplfig11_iii.tif
file_size: 55257
relation: main_file
success: 1
- access_level: open_access
checksum: 709fdd13b7e090846a4d8edd2425f675
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T13:59:32Z
date_updated: 2023-08-03T13:59:32Z
file_id: '13833'
file_name: Supplfig11_n2v+prediction.tif
file_size: 309457551
relation: main_file
success: 1
- access_level: open_access
checksum: e60ea3e6bb1bf380460d0d8ccdbd1f07
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:32Z
date_updated: 2023-08-03T14:14:32Z
file_id: '13834'
file_name: Supplfig12_a_01_n2v.tif
file_size: 119323629
relation: main_file
success: 1
- access_level: open_access
checksum: 2a4e1771e2f06383894361ba2a8155b4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:29Z
date_updated: 2023-08-03T14:14:29Z
file_id: '13835'
file_name: Supplfig12_a_01.tif
file_size: 59680727
relation: main_file
success: 1
- access_level: open_access
checksum: 993c434069b9d1bcb09bfe70628f5bbe
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:34Z
date_updated: 2023-08-03T14:14:34Z
file_id: '13836'
file_name: Supplfig12_a_02_n2v.tif
file_size: 106696749
relation: main_file
success: 1
- access_level: open_access
checksum: e3b6410d68e42004ef3857967707aeb3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:34Z
date_updated: 2023-08-03T14:14:34Z
file_id: '13837'
file_name: Supplfig12_a_02.tif
file_size: 53367287
relation: main_file
success: 1
- access_level: open_access
checksum: 0156e99806fe1539d5f48ea16c78e8c8
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:41Z
date_updated: 2023-08-03T14:14:41Z
file_id: '13838'
file_name: Supplfig12_a_03_n2v.tif
file_size: 149937979
relation: main_file
success: 1
- access_level: open_access
checksum: 6cc1533a221526a072a0b09fb44bcf50
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:39Z
date_updated: 2023-08-03T14:14:39Z
file_id: '13839'
file_name: Supplfig12_a_03.tif
file_size: 74987927
relation: main_file
success: 1
- access_level: open_access
checksum: f134834bd0d5e8c22e5a35aadf592007
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:53Z
date_updated: 2023-08-03T14:14:53Z
file_id: '13840'
file_name: Supplfig12_a_04_n2v.tif
file_size: 305581862
relation: main_file
success: 1
- access_level: open_access
checksum: 212ec76c02552fa1eef91e7bca9f07f7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:50Z
date_updated: 2023-08-03T14:14:50Z
file_id: '13841'
file_name: Supplfig12_a_04.tif
file_size: 152821840
relation: main_file
success: 1
- access_level: open_access
checksum: 7d99807d5b4313b04b4b5e0fbc08ba78
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:52Z
date_updated: 2023-08-03T14:14:52Z
file_id: '13842'
file_name: Supplfig12_a_05_n2v.tif
file_size: 48082029
relation: main_file
success: 1
- access_level: open_access
checksum: a6d4024a8c6fa073a532cc0c78323df7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:14:53Z
date_updated: 2023-08-03T14:14:53Z
file_id: '13843'
file_name: Supplfig12_a_05.tif
file_size: 24059983
relation: main_file
success: 1
- access_level: open_access
checksum: 1c42ad5423636478fe57495a3b506746
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:09Z
date_updated: 2023-08-03T14:15:09Z
file_id: '13844'
file_name: Supplfig12_a_06_n2v.tif
file_size: 305581860
relation: main_file
success: 1
- access_level: open_access
checksum: 821f1d31c6dbe68eb2513fb7520b5272
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:04Z
date_updated: 2023-08-03T14:15:04Z
file_id: '13845'
file_name: Supplfig12_a_06.tif
file_size: 152821840
relation: main_file
success: 1
- access_level: open_access
checksum: 86a4dc1e4948c4bc9c71e6d55b4fd104
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:08Z
date_updated: 2023-08-03T14:15:08Z
file_id: '13846'
file_name: Supplfig12_a_07_n2v.tif
file_size: 66855793
relation: main_file
success: 1
- access_level: open_access
checksum: fd5d45b1135800124fec635c4667dafe
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:09Z
date_updated: 2023-08-03T14:15:09Z
file_id: '13847'
file_name: Supplfig12_a_07.tif
file_size: 33446807
relation: main_file
success: 1
- access_level: open_access
checksum: 5683760cc119a09f0b7de8fea98cda9c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:19Z
date_updated: 2023-08-03T14:15:19Z
file_id: '13848'
file_name: Supplfig12_a_08_n2v.tif
file_size: 231476260
relation: main_file
success: 1
- access_level: open_access
checksum: 0c336d554bcd8524f11bd25c2188b56f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:15Z
date_updated: 2023-08-03T14:15:15Z
file_id: '13849'
file_name: Supplfig12_a_08.tif
file_size: 115769040
relation: main_file
success: 1
- access_level: open_access
checksum: fcaea6c95c363bd864a524fca8ed8e9b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:31Z
date_updated: 2023-08-03T14:15:31Z
file_id: '13850'
file_name: Supplfig12_a_09_n2v.tif
file_size: 305581869
relation: main_file
success: 1
- access_level: open_access
checksum: f401f1875f072c345d106a1e419f9d13
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:28Z
date_updated: 2023-08-03T14:15:28Z
file_id: '13851'
file_name: Supplfig12_a_09.tif
file_size: 152821840
relation: main_file
success: 1
- access_level: open_access
checksum: 7ad7d5b1ac81da1ec3d5003d00ee870a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:42Z
date_updated: 2023-08-03T14:15:42Z
file_id: '13852'
file_name: Supplfig12_a_10_n2v.tif
file_size: 266386255
relation: main_file
success: 1
- access_level: open_access
checksum: 77b93d082debd5248348c0a1e886eab9
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:40Z
date_updated: 2023-08-03T14:15:40Z
file_id: '13853'
file_name: Supplfig12_a_10.tif
file_size: 133239040
relation: main_file
success: 1
- access_level: open_access
checksum: 5ece1d503f05133d07d5b867f666d7a8
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:49Z
date_updated: 2023-08-03T14:15:49Z
file_id: '13854'
file_name: Supplfig12_a_11_n2v.tif
file_size: 191866269
relation: main_file
success: 1
- access_level: open_access
checksum: a72ee7ab433097752ff00a63421d4b61
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:15:48Z
date_updated: 2023-08-03T14:15:48Z
file_id: '13855'
file_name: Supplfig12_a_11.tif
file_size: 95955040
relation: main_file
success: 1
- access_level: open_access
checksum: c9c6e4692e0e7f305a43058b201b50d3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:16:49Z
date_updated: 2023-08-03T14:16:49Z
file_id: '13856'
file_name: Supplfig13_i.tif
file_size: 55281
relation: main_file
success: 1
- access_level: open_access
checksum: 345d11dbd70123d9d2723b547cbfc4fc
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:16:49Z
date_updated: 2023-08-03T14:16:49Z
file_id: '13857'
file_name: Supplfig13_ii.tif
file_size: 55193
relation: main_file
success: 1
- access_level: open_access
checksum: b4c74c08077cfd3e11bfd6ea9ee1c5b2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:16:49Z
date_updated: 2023-08-03T14:16:49Z
file_id: '13858'
file_name: Supplfig13_n2v+predict.tif
file_size: 539037
relation: main_file
success: 1
- access_level: open_access
checksum: 15f5b44257d075f9e45811304dfd5f85
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:18:10Z
date_updated: 2023-08-03T14:18:10Z
file_id: '13859'
file_name: Supplfig14_a_n2v.tif
file_size: 854898609
relation: main_file
success: 1
- access_level: open_access
checksum: a9ca03e3e5696988d06fc6ab1c103440
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T14:19:58Z
date_updated: 2023-08-03T14:19:58Z
file_id: '13860'
file_name: Supplfig15_a_1.png
file_size: 7514502
relation: main_file
success: 1
- access_level: open_access
checksum: 4be3451e203a0fc5d9eb14279ff68a7a
content_type: image/png
creator: jdanzl
date_created: 2023-08-03T14:19:58Z
date_updated: 2023-08-03T14:19:58Z
file_id: '13861'
file_name: Supplfig15_a_2.png
file_size: 1784041
relation: main_file
success: 1
- access_level: open_access
checksum: 43068c31eecddb798dbf2f51bda9b6c9
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:19:58Z
date_updated: 2023-08-03T14:19:58Z
file_id: '13862'
file_name: Supplfig15_b_1.tif
file_size: 6030878
relation: main_file
success: 1
- access_level: open_access
checksum: ded4c0797f1a9152dc3128f1bb8c32a5
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:19:58Z
date_updated: 2023-08-03T14:19:58Z
file_id: '13863'
file_name: Supplfig15_b_2.tif
file_size: 723293
relation: main_file
success: 1
- access_level: open_access
checksum: 705394732d94bd8463479aee83c2d36e
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:19:58Z
date_updated: 2023-08-03T14:19:58Z
file_id: '13864'
file_name: Supplfig15_c_i.tif
file_size: 723409
relation: main_file
success: 1
- access_level: open_access
checksum: e08efe220bec6a93d583cab17754dd19
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:19:58Z
date_updated: 2023-08-03T14:19:58Z
file_id: '13865'
file_name: Supplfig15_c_ii.tif
file_size: 723409
relation: main_file
success: 1
- access_level: open_access
checksum: 0e08e5d965815240b0a8195e0f899aab
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:19:59Z
date_updated: 2023-08-03T14:19:59Z
file_id: '13866'
file_name: Supplfig15_c.tif
file_size: 31572914
relation: main_file
success: 1
- access_level: open_access
checksum: 594696a77d4a9be512046be5e2d602f0
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:19:59Z
date_updated: 2023-08-03T14:19:59Z
file_id: '13867'
file_name: Supplfig15_d_1.tif
file_size: 6030752
relation: main_file
success: 1
- access_level: open_access
checksum: ffe6733eb77858008c4ca07b5f8c432b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:19:59Z
date_updated: 2023-08-03T14:19:59Z
file_id: '13868'
file_name: Supplfig15_d_2.tif
file_size: 8005495
relation: main_file
success: 1
- access_level: open_access
checksum: 663bf013cf1e5019e1e7ddd2d12fa492
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:20:56Z
date_updated: 2023-08-03T14:20:56Z
file_id: '13869'
file_name: Supplfig16_a.tif
file_size: 11117709
relation: main_file
success: 1
- access_level: open_access
checksum: 80aee233dc2a1f26ed8cc323270cf3a9
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:20:56Z
date_updated: 2023-08-03T14:20:56Z
file_id: '13870'
file_name: Supplfig16_b.tif
file_size: 113709
relation: main_file
success: 1
- access_level: open_access
checksum: 3b408e9345df2f16a942ad4ea61739b7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:20:56Z
date_updated: 2023-08-03T14:20:56Z
file_id: '13871'
file_name: Supplfig16_c.tif
file_size: 113709
relation: main_file
success: 1
- access_level: open_access
checksum: fbf688ef1f907149f92e9e936d02df72
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:47Z
date_updated: 2023-08-03T14:25:47Z
file_id: '13872'
file_name: Supplfig17_a_1.tif
file_size: 6003131
relation: main_file
success: 1
- access_level: open_access
checksum: 9a56470f251f14b43903036fab338f76
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:47Z
date_updated: 2023-08-03T14:25:47Z
file_id: '13873'
file_name: Supplfig17_a_2.tif
file_size: 8004085
relation: main_file
success: 1
- access_level: open_access
checksum: 4578c020ba5d0a6ffe2a8a1c22e52c75
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:47Z
date_updated: 2023-08-03T14:25:47Z
file_id: '13874'
file_name: Supplfig17_a_3.tif
file_size: 6003123
relation: main_file
success: 1
- access_level: open_access
checksum: a681d32f515da3bff8e803946f1d8b50
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:47Z
date_updated: 2023-08-03T14:25:47Z
file_id: '13875'
file_name: Supplfig17_a_4.tif
file_size: 6003131
relation: main_file
success: 1
- access_level: open_access
checksum: b89d366c39e25d17dc5d8ceee9145c8b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:47Z
date_updated: 2023-08-03T14:25:47Z
file_id: '13876'
file_name: Supplfig17_a_5.tif
file_size: 6003131
relation: main_file
success: 1
- access_level: open_access
checksum: 0b9d60f0aba79525a97c122d972f0b22
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:47Z
date_updated: 2023-08-03T14:25:47Z
file_id: '13877'
file_name: Supplfig17_a_6.tif
file_size: 6003079
relation: main_file
success: 1
- access_level: open_access
checksum: 169aad3cea521cc2a0ce4c3e41473e0c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:47Z
date_updated: 2023-08-03T14:25:47Z
file_id: '13878'
file_name: Supplfig17_a_7.tif
file_size: 6003115
relation: main_file
success: 1
- access_level: open_access
checksum: 39a44d77d9047bfa10da8d9c9bd7b391
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:47Z
date_updated: 2023-08-03T14:25:47Z
file_id: '13879'
file_name: Supplfig17_a_8.tif
file_size: 4002129
relation: main_file
success: 1
- access_level: open_access
checksum: f4ecb2bd44f2cea3d71587670344ac40
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:25:48Z
date_updated: 2023-08-03T14:25:48Z
file_id: '13880'
file_name: Supplfig17_b.tif
file_size: 8214335
relation: main_file
success: 1
- access_level: open_access
checksum: 44a20d2621680c90227416bf32b5a566
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:27:06Z
date_updated: 2023-08-03T14:27:06Z
file_id: '13881'
file_name: Supplfig18_a.tif
file_size: 7471479
relation: main_file
success: 1
- access_level: open_access
checksum: 5a5f7b616785f9213064e8c77f9d38c4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:27:06Z
date_updated: 2023-08-03T14:27:06Z
file_id: '13882'
file_name: Supplfig18_b.tif
file_size: 290625
relation: main_file
success: 1
- access_level: open_access
checksum: 8f621722a636e808a03d85f9597ad1a2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:27:07Z
date_updated: 2023-08-03T14:27:07Z
file_id: '13883'
file_name: Supplfig18_c.tif
file_size: 411767
relation: main_file
success: 1
- access_level: open_access
checksum: 3c8356f9170fe345e2ef725cd7d1b167
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:27:07Z
date_updated: 2023-08-03T14:27:07Z
file_id: '13884'
file_name: Supplfig18_d.tif
file_size: 11117685
relation: main_file
success: 1
- access_level: open_access
checksum: 5c8443e97724b54f359f7355483b890e
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:27:10Z
date_updated: 2023-08-03T14:27:10Z
file_id: '13885'
file_name: Supplfig18_e_n2v.tif
file_size: 259509773
relation: main_file
success: 1
- access_level: open_access
checksum: 413e3105c1bcd2ac2c569fa2b06253f2
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:29:25Z
date_updated: 2023-08-03T14:29:25Z
file_id: '13886'
file_name: Supplfig19_n2v.tif
file_size: 1430939360
relation: main_file
success: 1
- access_level: open_access
checksum: a864dc5b54f469c723e86286d538bb52
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:29:16Z
date_updated: 2023-08-03T14:29:16Z
file_id: '13887'
file_name: Supplfig19.tif
file_size: 715524468
relation: main_file
success: 1
- access_level: open_access
checksum: 8a78ce49446d207c0bf31196b788fa93
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13888'
file_name: Supplfig20_a_left.tif
file_size: 8004743
relation: main_file
success: 1
- access_level: open_access
checksum: 48fa3abfd16a00c7a3757d6452a482ec
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13889'
file_name: Supplfig20_a_right.tif
file_size: 5561081
relation: main_file
success: 1
- access_level: open_access
checksum: 85d82cd94dd3202f04b5987bc4466573
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13890'
file_name: Supplfig20_b_1.tif
file_size: 8456797
relation: main_file
success: 1
- access_level: open_access
checksum: e16f04d5d4d40f6ec33456d0cf02e1eb
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13891'
file_name: Supplfig20_b_2.tif
file_size: 8456795
relation: main_file
success: 1
- access_level: open_access
checksum: ff190edb269c28b25d27bffaeb7d25cf
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13892'
file_name: Supplfig20_b_3.tif
file_size: 8456796
relation: main_file
success: 1
- access_level: open_access
checksum: deb10b81bae62d9e20e681411fb75fcc
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13893'
file_name: Supplfig20_b_4.tif
file_size: 8538887
relation: main_file
success: 1
- access_level: open_access
checksum: 5c64bb94e76030d7a9d8624bac4b0f57
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13894'
file_name: Supplfig20_b_5.tif
file_size: 8538851
relation: main_file
success: 1
- access_level: open_access
checksum: d6c20232c4bd36e213b4c456c5009644
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13895'
file_name: Supplfig20_c_1.tif
file_size: 11077737
relation: main_file
success: 1
- access_level: open_access
checksum: 49c3396b8960af3f6fd8f6b078971d51
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:54Z
date_updated: 2023-08-03T14:32:54Z
file_id: '13896'
file_name: Supplfig20_c_2.tif
file_size: 11077737
relation: main_file
success: 1
- access_level: open_access
checksum: 73471528f691fb337839b84c31014da4
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:55Z
date_updated: 2023-08-03T14:32:55Z
file_id: '13897'
file_name: Supplfig20_c_3.tif
file_size: 11077737
relation: main_file
success: 1
- access_level: open_access
checksum: 47a0fd1a36d7e7907ce18007bdaaa145
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:55Z
date_updated: 2023-08-03T14:32:55Z
file_id: '13898'
file_name: Supplfig20_c_4.tif
file_size: 11077737
relation: main_file
success: 1
- access_level: open_access
checksum: 0c74b07f13fb08a91e61669368f38c9a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:55Z
date_updated: 2023-08-03T14:32:55Z
file_id: '13899'
file_name: Supplfig20_c_5.tif
file_size: 11077737
relation: main_file
success: 1
- access_level: open_access
checksum: fe3b76446ec8bd0d5cdba94a128a84b8
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:55Z
date_updated: 2023-08-03T14:32:55Z
file_id: '13900'
file_name: Supplfig20_d_1.tif
file_size: 4002133
relation: main_file
success: 1
- access_level: open_access
checksum: 0570bab9a471af3d0d1d8bf9a3cb17e7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:55Z
date_updated: 2023-08-03T14:32:55Z
file_id: '13901'
file_name: Supplfig20_d_2.tif
file_size: 4002133
relation: main_file
success: 1
- access_level: open_access
checksum: 59f330990b5c95f98a768761a009940c
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:55Z
date_updated: 2023-08-03T14:32:55Z
file_id: '13902'
file_name: Supplfig20_d_3.tif
file_size: 4002199
relation: main_file
success: 1
- access_level: open_access
checksum: f0da06f2a278dff4bbd1aeace11700bf
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:55Z
date_updated: 2023-08-03T14:32:55Z
file_id: '13903'
file_name: Supplfig20_d_4.tif
file_size: 4002133
relation: main_file
success: 1
- access_level: open_access
checksum: e61d49dcc0952af3623cc26a78cc6495
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:32:55Z
date_updated: 2023-08-03T14:32:55Z
file_id: '13904'
file_name: Supplfig20_d_5.tif
file_size: 4002133
relation: main_file
success: 1
- access_level: open_access
checksum: bcf8294487abaf1a75033f388fba06ec
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:42:01Z
date_updated: 2023-08-03T14:42:01Z
file_id: '13905'
file_name: Supplfig22_b_1.tif
file_size: 12627576
relation: main_file
success: 1
- access_level: open_access
checksum: 14097feb4a73e7bb1e1694cef0115cab
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:42:01Z
date_updated: 2023-08-03T14:42:01Z
file_id: '13906'
file_name: Supplfig22_b_2.tif
file_size: 8543366
relation: main_file
success: 1
- access_level: open_access
checksum: 7e74b8cff2ada56d47d135a6a9e71e76
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:42:04Z
date_updated: 2023-08-03T14:42:04Z
file_id: '13907'
file_name: Supplfig22_b_3.tif
file_size: 8394010
relation: main_file
success: 1
- access_level: open_access
checksum: f6e6e0f0e3854fedd201ab8ff08a7651
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T15:35:39Z
date_updated: 2023-08-03T15:35:39Z
file_id: '13908'
file_name: Supplfig22_b_4.tif
file_size: 8682992
relation: main_file
success: 1
- access_level: open_access
checksum: 6ddeb84249768b46b9c2072bf85bdc8b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:42:04Z
date_updated: 2023-08-03T14:42:04Z
file_id: '13909'
file_name: Supplfig22_b_5.tif
file_size: 8503466
relation: main_file
success: 1
- access_level: open_access
checksum: 40648b8a4ef375b8352f11a6772ea1a6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:42:04Z
date_updated: 2023-08-03T14:42:04Z
file_id: '13910'
file_name: Supplfig22_b_6.tif
file_size: 8543342
relation: main_file
success: 1
- access_level: open_access
checksum: 78f601de4d88f6ccb97861eaf4a995f8
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:42:06Z
date_updated: 2023-08-03T14:42:06Z
file_id: '13911'
file_name: Supplfig22_b_7.tif
file_size: 33588990
relation: main_file
success: 1
- access_level: open_access
checksum: 2873c488b7c8ad4d111726025086e9ea
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:42:41Z
date_updated: 2023-08-03T14:42:41Z
file_id: '13912'
file_name: Supplfig22_c.tif
file_size: 1453171518
relation: main_file
success: 1
- access_level: open_access
checksum: c1d0e5e61ac0d0ddf08704769f80ac78
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:47:43Z
date_updated: 2023-08-03T14:47:43Z
file_id: '13913'
file_name: Supplfig23_a.tif
file_size: 1325919782
relation: main_file
success: 1
- access_level: open_access
checksum: f97632984b6a73e06cc0c8c947cdcc71
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:47:25Z
date_updated: 2023-08-03T14:47:25Z
file_id: '13914'
file_name: Supplfig23_b.tif
file_size: 31366288
relation: main_file
success: 1
- access_level: open_access
checksum: 16f4c17835a79d7c06e2a97b1603baf1
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:47:26Z
date_updated: 2023-08-03T14:47:26Z
file_id: '13915'
file_name: Supplfig23_c.tif
file_size: 31366288
relation: main_file
success: 1
- access_level: open_access
checksum: 00f35ca77165642ca9b3bc3608bd04c1
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:47:27Z
date_updated: 2023-08-03T14:47:27Z
file_id: '13916'
file_name: Supplfig23_d.tif
file_size: 31366428
relation: main_file
success: 1
- access_level: open_access
checksum: 1aff850f47ae8c8f05ca48ff9faa38b1
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:47:27Z
date_updated: 2023-08-03T14:47:27Z
file_id: '13917'
file_name: Supplfig23_e.tif
file_size: 31500832
relation: main_file
success: 1
- access_level: open_access
checksum: f644de697d142c83461ed5ad1d72a043
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:48:38Z
date_updated: 2023-08-03T14:48:38Z
file_id: '13918'
file_name: Supplfig24_a_i.tif
file_size: 44179078
relation: main_file
success: 1
- access_level: open_access
checksum: eccb84925a6699b396d4b07efcbc7349
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:48:38Z
date_updated: 2023-08-03T14:48:38Z
file_id: '13919'
file_name: Supplfig24_a_ii.tif
file_size: 44125924
relation: main_file
success: 1
- access_level: open_access
checksum: afe7253e70ec79144e59b28c3c66703a
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:48:54Z
date_updated: 2023-08-03T14:48:54Z
file_id: '13920'
file_name: Supplfig24_a.tif
file_size: 1061835435
relation: main_file
success: 1
- access_level: open_access
checksum: 94a03b022aa84ea6e8515450a481ad82
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:48:39Z
date_updated: 2023-08-03T14:48:39Z
file_id: '13921'
file_name: Supplfig24_b_iii.tif
file_size: 3977824
relation: main_file
success: 1
- access_level: open_access
checksum: 166832c173fcda88ec6e35decdf0d197
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:48:39Z
date_updated: 2023-08-03T14:48:39Z
file_id: '13922'
file_name: Supplfig24_b_iv.tif
file_size: 3977825
relation: main_file
success: 1
- access_level: open_access
checksum: 53175073b83ab569241ae64ef7f180b3
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:51:27Z
date_updated: 2023-08-03T14:51:27Z
file_id: '13923'
file_name: Supplfig25_a_1.tif
file_size: 37641738
relation: main_file
success: 1
- access_level: open_access
checksum: 70e6a1780daeae6a5bef2c27c996c442
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:51:26Z
date_updated: 2023-08-03T14:51:26Z
file_id: '13924'
file_name: Supplfig25_a_2.tif
file_size: 4932897
relation: main_file
success: 1
- access_level: open_access
checksum: 1748266d7b8a2ae1f6292b9c265c2068
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:51:31Z
date_updated: 2023-08-03T14:51:31Z
file_id: '13925'
file_name: Supplfig25_b_1.tif
file_size: 357433570
relation: main_file
success: 1
- access_level: open_access
checksum: 8490f44160a482ea06d858eb3bc25a11
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:51:27Z
date_updated: 2023-08-03T14:51:27Z
file_id: '13926'
file_name: Supplfig25_b_2.tif
file_size: 27734506
relation: main_file
success: 1
- access_level: open_access
checksum: e5e9c550cc934a7725dc209c79951847
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:43Z
date_updated: 2023-08-03T14:53:43Z
file_id: '13927'
file_name: Suppfig26_h.tif
file_size: 35082394
relation: main_file
success: 1
- access_level: open_access
checksum: 39ae411d1e950e78bdc12937fb36f661
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:42Z
date_updated: 2023-08-03T14:53:42Z
file_id: '13928'
file_name: Supplfig26_a_1.tif
file_size: 16676477
relation: main_file
success: 1
- access_level: open_access
checksum: 450f5d0e8091639e27eb7a7991524e88
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:42Z
date_updated: 2023-08-03T14:53:42Z
file_id: '13929'
file_name: Supplfig26_a_2.tif
file_size: 170493
relation: main_file
success: 1
- access_level: open_access
checksum: 8e5a71801fa1fcb7f679d1af23344662
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:43Z
date_updated: 2023-08-03T14:53:43Z
file_id: '13930'
file_name: Supplfig26_b_1.tif
file_size: 11117737
relation: main_file
success: 1
- access_level: open_access
checksum: 519fb0326a0f0774b3edc1dafffcdd08
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:43Z
date_updated: 2023-08-03T14:53:43Z
file_id: '13931'
file_name: Supplfig26_b_2.tif
file_size: 113753
relation: main_file
success: 1
- access_level: open_access
checksum: d051c7d717eeb6f2ca59d8727ea62200
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:52Z
date_updated: 2023-08-03T14:53:52Z
file_id: '13932'
file_name: Supplfig26_c.tif
file_size: 495452386
relation: main_file
success: 1
- access_level: open_access
checksum: 5437b53e708572e2e9ad1432c260a04f
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:46Z
date_updated: 2023-08-03T14:53:46Z
file_id: '13933'
file_name: Supplfig26_d.tif
file_size: 132167170
relation: main_file
success: 1
- access_level: open_access
checksum: 0baab38829a8587ded5e39f85068124b
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:46Z
date_updated: 2023-08-03T14:53:46Z
file_id: '13934'
file_name: Supplfig26_e.tif
file_size: 11431214
relation: main_file
success: 1
- access_level: open_access
checksum: afa57f254c9dd987d90d5e43db3fb9e6
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:48Z
date_updated: 2023-08-03T14:53:48Z
file_id: '13935'
file_name: Supplfig26_f.tif
file_size: 64005702
relation: main_file
success: 1
- access_level: open_access
checksum: c35ba67ab92c410cb4370f91f3dea819
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:53:52Z
date_updated: 2023-08-03T14:53:52Z
file_id: '13936'
file_name: Supplfig26_g.tif
file_size: 246421054
relation: main_file
success: 1
- access_level: open_access
checksum: 3fd6186d73cbce1be79cf14a94a7f3bd
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:43Z
date_updated: 2023-08-03T14:56:43Z
file_id: '13937'
file_name: Supplfig27_a.tif
file_size: 166614932
relation: main_file
success: 1
- access_level: open_access
checksum: d1fc4c88e8e258e4e536a26e196d09b0
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:42Z
date_updated: 2023-08-03T14:56:42Z
file_id: '13938'
file_name: Supplfig27_b.tif
file_size: 143583446
relation: main_file
success: 1
- access_level: open_access
checksum: 8d6985530e86f38548e89e6380d73771
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:47Z
date_updated: 2023-08-03T14:56:47Z
file_id: '13939'
file_name: Supplfig27_c.tif
file_size: 172528188
relation: main_file
success: 1
- access_level: open_access
checksum: d0b1309d2120892ede84e04fdf0dbfbf
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:46Z
date_updated: 2023-08-03T14:56:46Z
file_id: '13940'
file_name: Supplfig27_d.tif
file_size: 113699256
relation: main_file
success: 1
- access_level: open_access
checksum: 4789b5254d0415ce314fc9e39cc52121
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:47Z
date_updated: 2023-08-03T14:56:47Z
file_id: '13941'
file_name: Supplfig27_e.tif
file_size: 88664548
relation: main_file
success: 1
- access_level: open_access
checksum: 7ff2d06534f062b0f17dab181f6c1f4e
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:47Z
date_updated: 2023-08-03T14:56:47Z
file_id: '13942'
file_name: Supplfig27_f.tif
file_size: 2298356
relation: main_file
success: 1
- access_level: open_access
checksum: 46de66d457b0def90f753c11927536b7
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:47Z
date_updated: 2023-08-03T14:56:47Z
file_id: '13943'
file_name: Supplfig27_g_1.tif
file_size: 499618
relation: main_file
success: 1
- access_level: open_access
checksum: 9ef5fba064a73a79dbc74b5e166d08ec
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:50Z
date_updated: 2023-08-03T14:56:50Z
file_id: '13944'
file_name: Supplfig27_g_2.tif
file_size: 202079026
relation: main_file
success: 1
- access_level: open_access
checksum: bf956c2b58d3da2baa869db5206d8d49
content_type: image/tiff
creator: jdanzl
date_created: 2023-08-03T14:56:48Z
date_updated: 2023-08-03T14:56:48Z
file_id: '13945'
file_name: Supplfig27_g_3.tif
file_size: 14639269
relation: main_file
success: 1
- access_level: open_access
checksum: 327dca11f42d5375d7f47f4cbd5b36c0
content_type: application/octet-stream
creator: jdanzl
date_created: 2023-08-03T15:21:01Z
date_updated: 2023-08-03T15:21:01Z
file_id: '13946'
file_name: model.p
file_size: 279467712
relation: main_file
success: 1
file_date_updated: 2023-08-04T13:19:47Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03600
name: Optical control of synaptic function via adhesion molecules
- _id: 26AA4EF2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
- _id: 23889792-32DE-11EA-91FC-C7463DDC885E
name: High content imaging to decode human immune cell interactions in health and
allergic disease
- _id: 25444568-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715508'
name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo
and in vitro Models
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9
call_identifier: H2020
grant_number: '101026635'
name: Synaptic computations of the hippocampal CA3 circuitry
publisher: Institute of Science and Technology Austria
related_material:
link:
- description: 'Original data for Fig. 5d, Fig. 5d (N2V) and Fig. 5f-i, provided
via an external link due to the large size (>10GB) of the datasets. '
relation: research_data
url: https://pub.ista.ac.at/group_danzl/data/CATS/
record:
- id: '14257'
relation: used_in_publication
status: public
status: public
title: Research data for the publication "Imaging brain tissue architecture across
millimeter to nanometer scales"
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '13116'
abstract:
- lang: eng
text: 'The emergence of large-scale order in self-organized systems relies on local
interactions between individual components. During bacterial cell division, FtsZ
-- a prokaryotic homologue of the eukaryotic protein tubulin -- polymerizes into
treadmilling filaments that further organize into a cytoskeletal ring. In vitro,
FtsZ filaments can form dynamic chiral assemblies. However, how the active and
passive properties of individual filaments relate to these large-scale self-organized
structures remains poorly understood. Here, we connect single filament properties
with the mesoscopic scale by combining minimal active matter simulations and biochemical
reconstitution experiments. We show that density and flexibility of active chiral
filaments define their global order. At intermediate densities, curved, flexible
filaments organize into chiral rings and polar bands. An effectively nematic organization
dominates for high densities and for straight, mutant filaments with increased
rigidity. Our predicted phase diagram captures these features quantitatively,
demonstrating how the flexibility, density and chirality of active filaments affect
their collective behaviour. Our findings shed light on the fundamental properties
of active chiral matter and explain how treadmilling FtsZ filaments organize during
bacterial cell division. '
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: 'This work was supported by the European Research Council through
grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607
to M.L., B. P.M. was also supported by the Kanazawa University WPI- NanoLSI Bio-SPM
collaborative research program. Z.D. has received funding from Doctoral Programme
of the Austrian Academy of Sciences (OeAW): Grant agreement 26360. We thank Jan
Brugues (MPI CBG, Dresden, Germany), Andela Saric (ISTA, Klosterneuburg, Austria),
Daniel Pearce (Uni Geneva, Switzerland) for valuable scientific input and comments
on the manuscript. We are also thankful for the support by the Scientific Service
Units (SSU) of IST Austria through resources provided by the Imaging and Optics
Facility (IOF) and the Lab Support Facility (LSF). '
article_processing_charge: No
author:
- first_name: Zuzana
full_name: Dunajova, Zuzana
id: 4B39F286-F248-11E8-B48F-1D18A9856A87
last_name: Dunajova
- first_name: Batirtze
full_name: Prats Mateu, Batirtze
id: 299FE892-F248-11E8-B48F-1D18A9856A87
last_name: Prats Mateu
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: '0000-0001-9198-2182 '
- first_name: Keesiang
full_name: Lim, Keesiang
last_name: Lim
- first_name: Dörte
full_name: Brandis, Dörte
last_name: Brandis
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Richard W.
full_name: Wong, Richard W.
last_name: Wong
- first_name: Jens
full_name: Elgeti, Jens
last_name: Elgeti
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: Dunajova Z, Prats Mateu B, Radler P, et al. Chiral and nematic phases of flexible
active filaments. 2023. doi:10.15479/AT:ISTA:13116
apa: Dunajova, Z., Prats Mateu, B., Radler, P., Lim, K., Brandis, D., Velicky, P.,
… Loose, M. (2023). Chiral and nematic phases of flexible active filaments. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:13116
chicago: Dunajova, Zuzana, Batirtze Prats Mateu, Philipp Radler, Keesiang Lim, Dörte
Brandis, Philipp Velicky, Johann G Danzl, et al. “Chiral and Nematic Phases of
Flexible Active Filaments.” Institute of Science and Technology Austria, 2023.
https://doi.org/10.15479/AT:ISTA:13116.
ieee: Z. Dunajova et al., “Chiral and nematic phases of flexible active filaments.”
Institute of Science and Technology Austria, 2023.
ista: Dunajova Z, Prats Mateu B, Radler P, Lim K, Brandis D, Velicky P, Danzl JG,
Wong RW, Elgeti J, Hannezo EB, Loose M. 2023. Chiral and nematic phases of flexible
active filaments, Institute of Science and Technology Austria, 10.15479/AT:ISTA:13116.
mla: Dunajova, Zuzana, et al. Chiral and Nematic Phases of Flexible Active Filaments.
Institute of Science and Technology Austria, 2023, doi:10.15479/AT:ISTA:13116.
short: Z. Dunajova, B. Prats Mateu, P. Radler, K. Lim, D. Brandis, P. Velicky, J.G.
Danzl, R.W. Wong, J. Elgeti, E.B. Hannezo, M. Loose, (2023).
date_created: 2023-06-02T12:30:40Z
date_published: 2023-07-26T00:00:00Z
date_updated: 2024-02-21T12:19:09Z
day: '26'
ddc:
- '539'
department:
- _id: MaLo
- _id: EdHa
- _id: JoDa
doi: 10.15479/AT:ISTA:13116
ec_funded: 1
file:
- access_level: open_access
checksum: 4b4ec5d4df7672b3af5ba23b126b171b
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: pradler
date_created: 2023-08-08T11:17:28Z
date_updated: 2023-08-08T11:17:28Z
file_id: '13983'
file_name: ReadMe File.docx
file_size: 13111
relation: main_file
success: 1
- access_level: open_access
checksum: 6f1673d6ae4f547cd49cfe7f87d9ab7e
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T06:55:43Z
date_updated: 2023-07-25T06:55:43Z
file_id: '13298'
file_name: TIRF_FtsZ WT 0.625µM.7z.001
file_size: 1499504777
relation: main_file
success: 1
- access_level: open_access
checksum: bc0dea871af164f7419ac838a34a4162
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T08:31:07Z
date_updated: 2023-07-25T08:31:07Z
file_id: '13306'
file_name: TIRF_FtsZ WT 0.900µM.7z.001
file_size: 3986437211
relation: main_file
success: 1
- access_level: open_access
checksum: dde91b799364a8456ac463dcba7bf37d
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T06:56:54Z
date_updated: 2023-07-25T06:56:54Z
file_id: '13299'
file_name: TIRF_FtsZ WT 1.15µM.7z.001
file_size: 1292391225
relation: main_file
success: 1
- access_level: open_access
checksum: ba59f4e3f062b378f45e579ec28898ce
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T08:25:07Z
date_updated: 2023-07-25T08:25:07Z
file_id: '13305'
file_name: TIRF_FtsZ WT 1.25µM.7z.001
file_size: 4494279051
relation: main_file
success: 1
- access_level: open_access
checksum: 906e1fe2aaacd1a746c49ffe39bcca66
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T08:12:32Z
date_updated: 2023-07-25T08:12:32Z
file_id: '13303'
file_name: TIRF_FtsZ WT 1.50µM.7z.001
file_size: 4697620480
relation: main_file
success: 1
- access_level: open_access
checksum: 96e416494b129cb0139c8250246bfaff
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T08:18:54Z
date_updated: 2023-07-25T08:18:54Z
file_id: '13304'
file_name: TIRF_FtsZ WT 1.50µM.7z.002
file_size: 3548897162
relation: main_file
success: 1
- access_level: open_access
checksum: f1dfdee3d833cf8d2c6b3ecbbee566f3
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T06:59:59Z
date_updated: 2023-07-25T06:59:59Z
file_id: '13300'
file_name: TIRF_FtsZ WT 2.0µM.7z.001
file_size: 1472947913
relation: main_file
success: 1
- access_level: open_access
checksum: fe77296c7bfce8b95a67ecbbb07ced81
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T07:05:40Z
date_updated: 2023-07-25T07:05:40Z
file_id: '13301'
file_name: TIRF_FtsZ WT 3.0µM.7z.001
file_size: 1993549431
relation: main_file
success: 1
- access_level: open_access
checksum: 6bc6edb807f38b00528875b4e7070bbf
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T07:06:07Z
date_updated: 2023-07-25T07:06:07Z
file_id: '13302'
file_name: TIRF_FtsZ WT 5.0µM.7z.001
file_size: 1336984015
relation: main_file
success: 1
- access_level: open_access
checksum: e46bbe73e90dc56e245ecda464930009
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T12:10:55Z
date_updated: 2023-07-24T12:10:55Z
file_id: '13281'
file_name: STED experiments.7z.001
file_size: 227620212
relation: main_file
success: 1
- access_level: open_access
checksum: 473aa9f1c097b8b03294b1f6d4f4aa04
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T09:16:06Z
date_updated: 2023-07-25T09:16:06Z
file_id: '13307'
file_name: AFM_FtsZ WT.7z.001
file_size: 3433349230
relation: main_file
success: 1
- access_level: open_access
checksum: bc685a414d95bcd5bba4dcad0187e928
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T12:11:54Z
date_updated: 2023-07-24T12:11:54Z
file_id: '13282'
file_name: TIRF_FtsZ WT and L169R intensity calibration.7z.001
file_size: 1416013335
relation: main_file
success: 1
- access_level: open_access
checksum: e6cac262a3cf5a6a45bf28edf1dac8cd
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T12:26:12Z
date_updated: 2023-07-24T12:26:12Z
file_id: '13285'
file_name: TIRF_FtsZ L169R below 0.6µM.7z
file_size: 2711456292
relation: main_file
success: 1
- access_level: open_access
checksum: 755179b242a7a4ee03133a15c5eab4ce
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T19:19:25Z
date_updated: 2023-07-24T19:19:25Z
file_id: '13296'
file_name: TIRF_FtsZ L169R 0.625µM.7z
file_size: 2272169467
relation: main_file
success: 1
- access_level: open_access
checksum: 7179ce242938a688381d7126b9a7ec45
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T13:02:04Z
date_updated: 2023-07-24T13:02:04Z
file_id: '13287'
file_name: TIRF_FtsZ L169R 0.900µM.7z
file_size: 2915542985
relation: main_file
success: 1
- access_level: open_access
checksum: a808996cbca0f795e00de85f1922b497
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T15:27:17Z
date_updated: 2023-07-24T15:27:17Z
file_id: '13294'
file_name: TIRF_FtsZ L169R 1.15µM.7z
file_size: 2769959727
relation: main_file
success: 1
- access_level: open_access
checksum: 9a42594d749e648a099fefd3e24108a8
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T19:22:29Z
date_updated: 2023-07-24T19:22:29Z
file_id: '13297'
file_name: TIRF_FtsZ L169R 1.25uM.7z
file_size: 4440142247
relation: main_file
success: 1
- access_level: open_access
checksum: d8df3e458dbdb83622ab4dd6c9313a4e
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T15:27:09Z
date_updated: 2023-07-24T15:27:09Z
file_id: '13295'
file_name: TIRF_FtsZ L169R 1.50µM.7z
file_size: 2727119370
relation: main_file
success: 1
- access_level: open_access
checksum: 020db3ef1d1cbfb3cbe5bf49d6669849
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T12:12:41Z
date_updated: 2023-07-24T12:12:41Z
file_id: '13283'
file_name: TIRF_FtsZ L169R 2.0µM.7z
file_size: 1479677783
relation: main_file
success: 1
- access_level: open_access
checksum: 22f2aa112442fb767c0a58876d974ab0
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-24T12:13:51Z
date_updated: 2023-07-24T12:13:51Z
file_id: '13284'
file_name: TIRF_FtsZ L169R 3.0µM.7z
file_size: 1560846342
relation: main_file
success: 1
- access_level: open_access
checksum: 6fac58e020d7b30092945cb210100670
content_type: application/octet-stream
creator: pradler
date_created: 2023-07-25T09:12:45Z
date_updated: 2023-07-25T09:12:45Z
file_id: '13308'
file_name: AFM_FtsZ L169R.7z.001
file_size: 2918160653
relation: main_file
success: 1
- access_level: open_access
checksum: 3cdbf4a61857cb940439473c999bdfa6
content_type: text/csv
creator: mloose
date_created: 2023-08-03T19:50:52Z
date_updated: 2023-08-03T19:50:52Z
file_id: '13947'
file_name: EDFig4p_F5.csv
file_size: 77476061
relation: main_file
success: 1
- access_level: open_access
checksum: a59d5b825b4fe830cdb8833b4851508d
content_type: text/csv
creator: mloose
date_created: 2023-08-03T19:50:50Z
date_updated: 2023-08-03T19:50:50Z
file_id: '13948'
file_name: EDFig4p_F40.csv
file_size: 74938608
relation: main_file
success: 1
- access_level: open_access
checksum: fe40a48ed7708260557faa1e7e8687d4
content_type: text/csv
creator: mloose
date_created: 2023-08-03T19:51:14Z
date_updated: 2023-08-03T19:51:14Z
file_id: '13949'
file_name: EDFig4p_F200.csv
file_size: 81680327
relation: main_file
success: 1
- access_level: open_access
checksum: 30bebf102f03445445f3dd3c19209497
content_type: text/csv
creator: mloose
date_created: 2023-08-03T19:51:45Z
date_updated: 2023-08-03T19:51:45Z
file_id: '13950'
file_name: Fig3a_4b_F40.csv
file_size: 169151538
relation: main_file
success: 1
- access_level: open_access
checksum: 29db5611c9e622710fbf7b1c83c621ec
content_type: text/csv
creator: mloose
date_created: 2023-08-03T19:51:45Z
date_updated: 2023-08-03T19:51:45Z
file_id: '13951'
file_name: Fig3a_F5.csv
file_size: 94791496
relation: main_file
success: 1
- access_level: open_access
checksum: 848456b4230c086e8999f57d57dba7f1
content_type: text/csv
creator: mloose
date_created: 2023-08-03T19:51:54Z
date_updated: 2023-08-03T19:51:54Z
file_id: '13952'
file_name: Fig3a_F200.csv
file_size: 59166206
relation: main_file
success: 1
file_date_updated: 2023-08-08T11:17:28Z
has_accepted_license: '1'
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 2595697A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '679239'
name: Self-Organization of the Bacterial Cell
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
grant_number: P34607
name: "Understanding bacterial cell division by in vitro\r\nreconstitution"
- _id: 34d75525-11ca-11ed-8bc3-89b6307fee9d
grant_number: '26360'
name: Motile active matter models of migrating cells and chiral filaments
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '13314'
relation: used_in_publication
status: public
status: public
title: Chiral and nematic phases of flexible active filaments
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '13314'
abstract:
- lang: eng
text: The emergence of large-scale order in self-organized systems relies on local
interactions between individual components. During bacterial cell division, FtsZ—a
prokaryotic homologue of the eukaryotic protein tubulin—polymerizes into treadmilling
filaments that further organize into a cytoskeletal ring. In vitro, FtsZ filaments
can form dynamic chiral assemblies. However, how the active and passive properties
of individual filaments relate to these large-scale self-organized structures
remains poorly understood. Here we connect single-filament properties with the
mesoscopic scale by combining minimal active matter simulations and biochemical
reconstitution experiments. We show that the density and flexibility of active
chiral filaments define their global order. At intermediate densities, curved,
flexible filaments organize into chiral rings and polar bands. An effectively
nematic organization dominates for high densities and for straight, mutant filaments
with increased rigidity. Our predicted phase diagram quantitatively captures these
features, demonstrating how the flexibility, density and chirality of the active
filaments affect their collective behaviour. Our findings shed light on the fundamental
properties of active chiral matter and explain how treadmilling FtsZ filaments
organize during bacterial cell division.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: 'This work was supported by the European Research Council through
grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607
to M.L., B. P.M. was also supported by the Kanazawa University WPI- NanoLSI Bio-SPM
collaborative research program. Z.D. has received funding from Doctoral Programme
of the Austrian Academy of Sciences (OeAW): Grant agreement 26360. We thank Jan
Brugues (MPI CBG, Dresden, Germany), Andela Saric (ISTA, Klosterneuburg, Austria),
Daniel Pearce (Uni Geneva, Switzerland) for valuable scientific input and comments
on the manuscript. We are also thankful for the support by the Scientific Service
Units (SSU) of IST Austria through resources provided by the Imaging and Optics
Facility (IOF) and the Lab Support Facility (LSF).'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Zuzana
full_name: Dunajova, Zuzana
id: 4B39F286-F248-11E8-B48F-1D18A9856A87
last_name: Dunajova
- first_name: Batirtze
full_name: Prats Mateu, Batirtze
id: 299FE892-F248-11E8-B48F-1D18A9856A87
last_name: Prats Mateu
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: '0000-0001-9198-2182 '
- first_name: Keesiang
full_name: Lim, Keesiang
last_name: Lim
- first_name: Dörte
full_name: Brandis, Dörte
id: 21d64d35-f128-11eb-9611-b8bcca7a12fd
last_name: Brandis
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Richard W.
full_name: Wong, Richard W.
last_name: Wong
- first_name: Jens
full_name: Elgeti, Jens
last_name: Elgeti
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: Dunajova Z, Prats Mateu B, Radler P, et al. Chiral and nematic phases of flexible
active filaments. Nature Physics. 2023;19:1916-1926. doi:10.1038/s41567-023-02218-w
apa: Dunajova, Z., Prats Mateu, B., Radler, P., Lim, K., Brandis, D., Velicky, P.,
… Loose, M. (2023). Chiral and nematic phases of flexible active filaments. Nature
Physics. Springer Nature. https://doi.org/10.1038/s41567-023-02218-w
chicago: Dunajova, Zuzana, Batirtze Prats Mateu, Philipp Radler, Keesiang Lim, Dörte
Brandis, Philipp Velicky, Johann G Danzl, et al. “Chiral and Nematic Phases of
Flexible Active Filaments.” Nature Physics. Springer Nature, 2023. https://doi.org/10.1038/s41567-023-02218-w.
ieee: Z. Dunajova et al., “Chiral and nematic phases of flexible active filaments,”
Nature Physics, vol. 19. Springer Nature, pp. 1916–1926, 2023.
ista: Dunajova Z, Prats Mateu B, Radler P, Lim K, Brandis D, Velicky P, Danzl JG,
Wong RW, Elgeti J, Hannezo EB, Loose M. 2023. Chiral and nematic phases of flexible
active filaments. Nature Physics. 19, 1916–1926.
mla: Dunajova, Zuzana, et al. “Chiral and Nematic Phases of Flexible Active Filaments.”
Nature Physics, vol. 19, Springer Nature, 2023, pp. 1916–26, doi:10.1038/s41567-023-02218-w.
short: Z. Dunajova, B. Prats Mateu, P. Radler, K. Lim, D. Brandis, P. Velicky, J.G.
Danzl, R.W. Wong, J. Elgeti, E.B. Hannezo, M. Loose, Nature Physics 19 (2023)
1916–1926.
date_created: 2023-07-27T14:44:45Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2024-02-21T12:19:08Z
day: '01'
ddc:
- '530'
department:
- _id: JoDa
- _id: EdHa
- _id: MaLo
- _id: GradSch
doi: 10.1038/s41567-023-02218-w
ec_funded: 1
external_id:
pmid:
- '38075437'
file:
- access_level: open_access
checksum: bc7673ca07d37309013a86166577b2f7
content_type: application/pdf
creator: dernst
date_created: 2024-01-30T14:28:30Z
date_updated: 2024-01-30T14:28:30Z
file_id: '14916'
file_name: 2023_NaturePhysics_Dunajova.pdf
file_size: 22471673
relation: main_file
success: 1
file_date_updated: 2024-01-30T14:28:30Z
has_accepted_license: '1'
intvolume: ' 19'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 1916-1926
pmid: 1
project:
- _id: 2595697A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '679239'
name: Self-Organization of the Bacterial Cell
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
grant_number: P34607
name: "Understanding bacterial cell division by in vitro\r\nreconstitution"
- _id: 34d75525-11ca-11ed-8bc3-89b6307fee9d
grant_number: '26360'
name: Motile active matter models of migrating cells and chiral filaments
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '13116'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Chiral and nematic phases of flexible active filaments
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...
---
_id: '14257'
abstract:
- lang: eng
text: Mapping the complex and dense arrangement of cells and their connectivity
in brain tissue demands nanoscale spatial resolution imaging. Super-resolution
optical microscopy excels at visualizing specific molecules and individual cells
but fails to provide tissue context. Here we developed Comprehensive Analysis
of Tissues across Scales (CATS), a technology to densely map brain tissue architecture
from millimeter regional to nanometer synaptic scales in diverse chemically fixed
brain preparations, including rodent and human. CATS uses fixation-compatible
extracellular labeling and optical imaging, including stimulated emission depletion
or expansion microscopy, to comprehensively delineate cellular structures. It
enables three-dimensional reconstruction of single synapses and mapping of synaptic
connectivity by identification and analysis of putative synaptic cleft regions.
Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed
and quantified the synaptic input and output structure of identified neurons.
We furthermore demonstrate applicability to clinically derived human tissue samples,
including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing
the cellular architecture of brain tissue in health and disease.
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
- _id: PreCl
- _id: LifeSc
- _id: M-Shop
- _id: E-Lib
acknowledgement: 'We thank J. Vorlaufer, N. Agudelo-Dueñas, W. Jahr and A. Wartak
for microscope maintenance and troubleshooting; C. Kreuzinger, A. Freeman and I.
Erber for technical assistance; and M. Tomschik for support with obtaining human
samples. We gratefully acknowledge E. Miguel for setting up webKnossos and M. Šuplata
for computational support and hardware control. We are grateful to R. Shigemoto
and B. Bickel for generous support and M. Sixt and S. Boyd (Stanford University)
for discussions and critical reading of the paper. PSD95-HaloTag mice were kindly
provided by S. Grant (University of Edinburgh). We acknowledge expert support by
Institute of Science and Technology Austria’s scientific computing, imaging and
optics, preclinical and lab support facilities and by the Miba machine shop and
library. We gratefully acknowledge funding by the following sources: Austrian Science
Fund (FWF) grant I3600-B27 (J.G.D.); Austrian Science Fund (FWF) grant DK W1232
(J.G.D. and J.M.M.); Austrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award
(P.J.); Austrian Science Fund (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27
(R.H.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.);
European Union’s Horizon 2020 research and innovation programme, European Research
Council (ERC) grant 715508 – REVERSEAUTISM (G.N.); European Union’s Horizon 2020
research and innovation programme, European Research Council (ERC) grant 692692
– GIANTSYN (P.J.); Marie Skłodowska-Curie Actions Fellowship GA no. 665385 under
the EU Horizon 2020 program (J.M.M. and J.L.); and Marie Skłodowska-Curie Actions
Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.).'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Julia M
full_name: Michalska, Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
orcid: 0000-0003-3862-1235
- first_name: Julia
full_name: Lyudchik, Julia
id: 46E28B80-F248-11E8-B48F-1D18A9856A87
last_name: Lyudchik
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Hana
full_name: Korinkova, Hana
id: ee3cb6ca-ec98-11ea-ae11-ff703e2254ed
last_name: Korinkova
- first_name: Jake
full_name: Watson, Jake
id: 63836096-4690-11EA-BD4E-32803DDC885E
last_name: Watson
orcid: 0000-0002-8698-3823
- first_name: Alban
full_name: Cenameri, Alban
id: 9ac8f577-2357-11eb-997a-e566c5550886
last_name: Cenameri
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Nicole
full_name: Amberg, Nicole
id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
last_name: Amberg
orcid: 0000-0002-3183-8207
- first_name: Alessandro
full_name: Venturino, Alessandro
id: 41CB84B2-F248-11E8-B48F-1D18A9856A87
last_name: Venturino
orcid: 0000-0003-2356-9403
- first_name: Karl
full_name: Roessler, Karl
last_name: Roessler
- first_name: Thomas
full_name: Czech, Thomas
last_name: Czech
- first_name: Romana
full_name: Höftberger, Romana
last_name: Höftberger
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
citation:
ama: Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture
across millimeter to nanometer scales. Nature Biotechnology. 2023. doi:10.1038/s41587-023-01911-8
apa: Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri,
A., … Danzl, J. G. (2023). Imaging brain tissue architecture across millimeter
to nanometer scales. Nature Biotechnology. Springer Nature. https://doi.org/10.1038/s41587-023-01911-8
chicago: Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake
Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture
across Millimeter to Nanometer Scales.” Nature Biotechnology. Springer
Nature, 2023. https://doi.org/10.1038/s41587-023-01911-8.
ieee: J. M. Michalska et al., “Imaging brain tissue architecture across millimeter
to nanometer scales,” Nature Biotechnology. Springer Nature, 2023.
ista: Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer
CM, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino
G, Jonas PM, Danzl JG. 2023. Imaging brain tissue architecture across millimeter
to nanometer scales. Nature Biotechnology.
mla: Michalska, Julia M., et al. “Imaging Brain Tissue Architecture across Millimeter
to Nanometer Scales.” Nature Biotechnology, Springer Nature, 2023, doi:10.1038/s41587-023-01911-8.
short: J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri,
C.M. Sommer, N. Amberg, A. Venturino, K. Roessler, T. Czech, R. Höftberger, S.
Siegert, G. Novarino, P.M. Jonas, J.G. Danzl, Nature Biotechnology (2023).
date_created: 2023-09-03T22:01:15Z
date_published: 2023-08-31T00:00:00Z
date_updated: 2024-02-21T12:18:18Z
day: '31'
department:
- _id: SaSi
- _id: GaNo
- _id: PeJo
- _id: JoDa
- _id: Bio
- _id: RySh
doi: 10.1038/s41587-023-01911-8
ec_funded: 1
external_id:
isi:
- '001065254200001'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41587-023-01911-8
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03600
name: Optical control of synaptic function via adhesion molecules
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
- _id: 23889792-32DE-11EA-91FC-C7463DDC885E
name: High content imaging to decode human immune cell interactions in health and
allergic disease
- _id: 25444568-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715508'
name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo
and in vitro Models
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9
call_identifier: H2020
grant_number: '101026635'
name: Synaptic computations of the hippocampal CA3 circuitry
publication: Nature Biotechnology
publication_identifier:
eissn:
- 1546-1696
issn:
- 1087-0156
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/danzllab/CATS
record:
- id: '13126'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Imaging brain tissue architecture across millimeter to nanometer scales
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12470'
abstract:
- lang: eng
text: "The brain is an exceptionally sophisticated organ consisting of billions
of cells and trillions of \r\nconnections that orchestrate our cognition and behavior.
To decode its complex connectivity, it is \r\npivotal to disentangle its intricate
architecture spanning from cm-sized circuits down to tens of \r\nnm-small synapses.\r\nTo
achieve this goal, I developed CATS – Comprehensive Analysis of nervous Tissue
across \r\nScales, a versatile toolbox for obtaining a holistic view of nervous
tissue context with (super\x02resolution) fluorescence microscopy. CATS combines
comprehensive labeling of the extracellular\r\nspace, that is compatible with
chemical fixation, with information on molecular markers, super\x02resolved data
acquisition and machine-learning based data analysis for segmentation and synapse
\r\nidentification.\r\nI used CATS to analyze key features of nervous tissue connectivity,
ranging from whole tissue \r\narchitecture, neuronal in- and output-fields, down
to synapse morphology.\r\nFocusing on the hippocampal circuitry, I quantified
synaptic transmission properties of mossy \r\nfiber boutons and analyzed the connectivity
pattern of dentate gyrus granule cells with CA3 \r\npyramidal neurons. This shows
that CATS is a viable tool to study hallmarks of neuronal \r\nconnectivity with
light microscopy."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
- _id: EM-Fac
- _id: M-Shop
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Julia M
full_name: Michalska, Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
orcid: 0000-0003-3862-1235
citation:
ama: Michalska JM. A versatile toolbox for the comprehensive analysis of nervous
tissue organization with light microscopy. 2023. doi:10.15479/at:ista:12470
apa: Michalska, J. M. (2023). A versatile toolbox for the comprehensive analysis
of nervous tissue organization with light microscopy. Institute of Science
and Technology Austria. https://doi.org/10.15479/at:ista:12470
chicago: Michalska, Julia M. “A Versatile Toolbox for the Comprehensive Analysis
of Nervous Tissue Organization with Light Microscopy.” Institute of Science and
Technology Austria, 2023. https://doi.org/10.15479/at:ista:12470.
ieee: J. M. Michalska, “A versatile toolbox for the comprehensive analysis of nervous
tissue organization with light microscopy,” Institute of Science and Technology
Austria, 2023.
ista: Michalska JM. 2023. A versatile toolbox for the comprehensive analysis of
nervous tissue organization with light microscopy. Institute of Science and Technology
Austria.
mla: Michalska, Julia M. A Versatile Toolbox for the Comprehensive Analysis of
Nervous Tissue Organization with Light Microscopy. Institute of Science and
Technology Austria, 2023, doi:10.15479/at:ista:12470.
short: J.M. Michalska, A Versatile Toolbox for the Comprehensive Analysis of Nervous
Tissue Organization with Light Microscopy, Institute of Science and Technology
Austria, 2023.
date_created: 2023-01-31T15:10:53Z
date_published: 2023-01-09T00:00:00Z
date_updated: 2023-08-31T12:26:58Z
day: '09'
ddc:
- '610'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoDa
doi: 10.15479/at:ista:12470
ec_funded: 1
file:
- access_level: open_access
checksum: 1a2306e5f59f52df598e7ecfadf921ac
content_type: application/pdf
creator: cchlebak
date_created: 2023-01-31T15:11:42Z
date_updated: 2023-07-27T22:30:54Z
embargo: 2023-07-09
file_id: '12471'
file_name: 20230109_PhD_thesis_JM_final.pdf
file_size: 41771714
relation: main_file
- access_level: closed
checksum: 0bebbdee0773443959e1f6ab8caf281f
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: cchlebak
date_created: 2023-01-31T15:11:51Z
date_updated: 2023-07-10T22:30:04Z
embargo_to: open_access
file_id: '12472'
file_name: 20230109_PhD_thesis_JM_final.docx
file_size: 66983464
relation: source_file
file_date_updated: 2023-07-27T22:30:54Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: '201'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 26AA4EF2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication_identifier:
isbn:
- ' 978-3-99078-026-8'
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11943'
relation: part_of_dissertation
status: public
- id: '11950'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
title: A versatile toolbox for the comprehensive analysis of nervous tissue organization
with light microscopy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...